This file provides an easy to use, fast compiled C program that runs in a DOS window for computing optimal and minimax two-stage designs for phase II clinical trials. The program is based on the paper by R. Simon: "Optimal two stage designs for phase II clinical trials", Controlled Clinical Trials 10:1-10, 1989. To use the program, open a DOS window using the command prompt menu item in your start menu. CD to the directory into which you have put the file, and execute it.
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.
The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.
Updates regarding government operating status and resumption of normal operations can be found at opm.gov.
