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Download the S-PLUS Program for the Analysis of Accelerated Titration Designs

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Download the SPlus Program

Instructions to Run the Downloaded File

Software requirements: S-PLUS 3.3 or higher (under MS Windows). Before running the program, load the functions by typing source('...../ph1atd').  To run the program, type ph1atd( 'inputfile' , 'doselist' ) at the S-PLUS prompt,  where the "inputfile" is an ASCII file which contains the patient data in the following format, one record(line) per course:

  • Column 1: patient number
  • Column 2: course number
  • Column 3: dose
  • Column 4: toxicity

(Records should be ordered by patient and course number) and "doselist" is an ASCII file which contains all the doses planned to be used in the trial listed in a single column in ascending order.

Program Output

  • Maximum likelihood estimates of the model parameters
  • Confidence intervals for parameters with non-zero MLE, both MLE and CI are sent to the screen and file "ph1atd.out"
  • Graph of probabilities of grade2+, 3+ and 4+ toxicities (for the first course) averaged over the population of patients. (the graph is stored in file "ph1atd1.wmf")
  • Graphs of probabilities of grade2+, 3+ and 4+ toxicities (for the first course) for the patients with beta equal to MLE-SD, MLE and MLE+SD. (the graphs are stored in file "ph1atd2.wmf")

Note: If the MLE of sigma beta is 0 these graphs are not produced.

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