Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

tmbLab

Calibration for a specific laboratory’s panel-based TMB diagnostic assay.

Calibration for a specific laboratory’s panel-based TMB diagnostic assay. Each plotted point represents WES TMB (x) and Panel TMB (y) for a particular sample in the training data set. The solid black line is the fitted weighted least squares regression line, and the dotted black lines are the corresponding 95% prediction limits. The value y0 is a hypothetical TMB value measured using the panel assay of interest. The WES-calibrated estimate for y0 is depicted by x0 on the x-axis. The interval of uncertainty around the WES-calibrated value, (LL95(y0), UL95(y0)), is indicated on the x-axis.

FOCR/NCI TMB Calibration Tool: tmbLab

Lisa McShane, Laura Yee, and Qian Xie

This package generates and applies a calibration model as described in phase 2 of the Friends of Cancer Research (FOCR) tumor mutational burden (TMB) harmonization project. The software estimates a calibration curve with corresponding prediction limits to quantify the average relationship between WES and panel TMB assay values as well as variability around that curve. Intervals of uncertainty are also provided to accompany the corresponding WES-calibrated TMB values.

Download the software

tmbLab_1.0.0.zip (Windows OS)

tmbLab_1.0.0.tar.gz (Source)

Vignettes

tmbLab Vignettes

Support

TMB.Project.Support@mail.nih.gov

If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “tmbLab was originally published by the National Cancer Institute.”

Email