Skip to main content
An official website of the United States government
NIH Websites Are Changing
Per Executive Order 14434, federal agencies are now using "Super Intelligence" (SI) in place of "Artificial Intelligence" (AI). You may see both terms across NIH content during this transition.

About BRB-ArrayTools

Expression Data

  • Supported Data Types 
BRB ArrayTools supported data types
  • Affymetrix 3'-IVT arrays
  • Affymetrix genechip ST 1.0 arrays
  • Agilent single and dual channel arrays
  • Illumina expression arrays
  • GenePix data
  • mAdb archive data
  • GDS datasets from NCBI/GEO
  • Other data types through general importer
  • RNA-Seq count data processed through Galaxy web tools
  • Class comparison for differential expression
    • Univariate tests with the option of random variance model 
Volcano plot from class comparison for differential expression in BRB ArrayTools
  • Multivariate permutation tests
  • Significance Analysis of Microarrays (SAM)
  • Lassoed Principal Components
  • Class prediction
    • Compound covariate predictor; SVM; Bayesian compound covariate; KNN; DLDA; 
BRB ArrayTools class prediction output
  • Nearest centroid
  • Adaboost
  • PAM
  • Lasso logistic regression
  • Binary tree prediction
  • Clustering 
BRB ArrayTools cluster analysis and dynamic heatmap
  • Interactive heatmap viewer, Hierarchical clustering, Non-negative matrix factorization clustering
  • 2-D and 3-D interactive Scatter-plot
    • Phenotype average
    • Array vs. Array
  • Gene Set Enrichment Analysis with many gene sets 
BRB ArrayTools gene set enrichment analysis
  • BioCarta, KEGG, CGAP, Broad Institute - MSigDB, Gene Ontology, Protein domain, Transcription factor targets, MicroRNA targets, User defined gene lists
  • Visualization of Samples 
BRB ArrayTools visualization of samples
  • 3-D interactive plot
  • Survival Analysis 
BRB ArrayTools survival analysis
  • Survival gene sets analysis
  • Survival risk prediction analysis
  • KEGG Pathway Graphic Tool
    • The Gene color coding for KEGG human disease pathways utility tool displays a KEGG disease pathway graph with selected genes being color-coded by their expression values or fold changes.  
BRB ArrayTools KEGG pathway network plot

Methylation Data

  • Import and process Illumina methylation data 
Process Illumina methylation data in BRB-ArrayTools
  • Find frequently methylated region
  • Create a heatmap with methylation data

Copy Number Data

  • Analyze copy number data in BRB CGHTools
  • Specification of Gain and Loss Calls analysis
BRB CGHTools Frequency Plot
Analyze copy number data in BRB CGHTools
  • Reviewed:
Email