Benefits of Nanotechnology for Cancer

**Progress in cancer nanotechnology requires a better understanding of how molecularly-targeted nanoparticles interact with live cells.** Here, cancer cells (cell nuclei in blue) were treated with antibody-conjugated nanoparticles (aEGFR-gold nanoparticles). After receptor-mediated endocytosis, the complex underwent thiol-mediated dissociation, resulting in the separation of antibodies (red) and nanoparticle cores (green) into distinct cellular compartments (Sangheon Han, et al., *ASC Nano*, 2021). This valuable insight may lead to improved methods of cancer detection *in vivo* as well as more effective nanoparticle-based treatments.

Credit: Sangheon Han, Konstantin Sokolov, Tomasz Zal, Anna Zal, M.D. Anderson Cancer Center

Modern medicine has significantly improved outcomes in cancer management. However, the disease still causes over 600,000 deaths in the United States every year. While cancer treatments have advanced significantly, the need to increase their specificity and reduce systemic toxicity remains a challenge. As illustrated in the diagram below, nanotechnology presents opportunities to (1) enhance earlier diagnosis through in vitro assays, (2) enhance imaging capabilities for diagnosis and treatment monitoring, and (3) improve therapeutic outcomes by refining targeting precision, augmenting localized drug efficacy, and minimizing systemic toxicity.

**Conventional cancer therapies, diagnostics, radiation treatments, and imaging can be significantly improved through nanotechnological applications.** Source: Jessica A. Kemp and Young Jik Kwon, *Nano Convergence*, 2021

Nanoparticlesare one hundred to ten thousand times smaller than human cells. They are thus uniquely able to interact with biomolecules both on the surface of cells and inside them. This broad access across various organs gives them the potential to change how we think about cancer detection and treatment, leading to a multitude of research publications (as depicted in the figure below, Carolina Salvador Morales and Piotr Grodzinski, WIREs Nanomedicine and Nanobiotechnology, 2023). The application of nanoscale materials in cancer research relies on their design flexibility and tunability. For example, gold nanoparticles can be readily decorated with different ligands on their surfaces to facilitate an understanding of how they interact with live cancer cells (as shown in the top right image). By enabling rapid and sensitive detection of cancer-related molecules, nanotechnology empowers scientists to detect molecular changes, even in a small percentage of cells. Moreover, nanotechnology has the potential to generate entirely novel and effective therapeutic agents. In addition, nanomaterials can passively accumulate at the tumor sites, actively target cancer cells, and traverse physiological barriers such as the blood-brain barrier or the stomach epithelium.