Proteomic Data Commons (PDC)
NCI’s Proteomic Data Commons (PDC) is part of the NCI’s Cancer Research Data Commons (CRDC) data ecosystem. It is the largest public repository of comprehensive tumor proteomic datasets and related data files. The PDC provides researchers access to the Office of Cancer Clinical Proteomics Research (OCCPR) -supported research programs. These include the Clinical Proteomic Tumor Analysis Consortium (CPTAC), the International Cancer Proteogenome Consortium (ICPC), the Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) network, and other contributors, such as the Children’s Brain Tumor Network (CBTN), and NCI Patient-Derived Models Repository (PDMR).
The PDC offers free access to raw mass spectrometry (MS)-based data files, including proteomes, various post-translational modifications, lipidome and metabolome data, along with highly curated and structured biospecimen and patient metadata. The PDC is seamlessly integrated with the Genomic Data Commons (GDC) and The Cancer Imaging Archive (TCIA) for multiomic datasets that have complementary genomics and imaging data. It also features a Common Data Analysis Pipeline (CDAP) to uniform proteomic data analysis and provides an intuitive web interface for exploration and visualization. Researchers can even perform in-cloud analysis within the CRDC ecosystem without data downloading, making the PDC a valuable resource for cancer research.
For easy access, data is organized by primary site, cancer type, experiment type, and acquisition type, and can be further explored with various metadata filters. Explore the PDC today and unlock new insights in cancer research!