The Co-Clinical Imaging Research Resources Program (CIRP)
NCI launched CIRP in 2015 to establish web-accessible, co-clinical, quantitative imaging research resources. CIRP focuses on optimization of quantitative imaging methods for precision medicine in preclinical and clinical settings.
Background on CIRP
CIRP is a trans-NCI initiative designed to:
- Provide the cancer community with web-accessible research resources for quantitative imaging in co-clinical trials (investigations in patients and mouse or human-in-mouse models)
- Encourage consensus on how quantitative imaging methods can be optimized to improve the quality of imaging results for co-clinical trials
- Leverage existing NCI resources and programs to ensure best practices, effective outreach, and rapid dissemination
Essential Components of CIRP Projects
CIRP projects include four essential components:
- Animal models (GEMMs or PDXs)
- Co-clinical therapeutic trials
- Quantitative preclinical and clinical imaging methods
- Informatics for supporting web-resources
Scientific Objectives of CIRP
The scientific objectives of the program are to:
- Provide cancer and imaging research communities with web-accessible resources for quantitative imaging in co-clinical trials
- Encourage consensus on how quantitative imaging methods can be optimized to improve the quality of imaging results for co-clinical trials.
CIRP Funded Projects and Web Resources
CIRP supports ten co-clinical trial projects that span a diverse range of tumor types, therapeutic interventions, and imaging modalities.
To facilitate co-clinical imaging research, each CIRP project establishes a web resource to disseminate freely accessible and comprehensive information on experimental design, protocol and software development, modeling and information extraction, biological and pathological validations, multiscale data integration, and preclinical-clinical correlations.
Select a column header to sort by Cancer and Award Year.
| Cancer | PI Names(s) (*Contact PIs) |
Institutes | Project/Web Resource | Award Year |
|---|---|---|---|---|
| Colorectal cancer | Charles Manning* Skott Kopetz |
MD Anderson Cancer Center | 2018 | |
| ER+/HER2- breast cancer | Kooresh Shoghi* Li Ding Shunqiang Li Cynthia Ma |
Washington University | 2022 | |
| Myelofibrosis cancer | Brian Ross* Thomas Chenevert Gary Luker Moshe Talpaz |
University of Michigan |
University of Michigan Quantitative Co-Clinical Imaging Research Resource |
2019 |
| Non-small cell lung cancer | Paul Kinahan* A. McGarry Houghton |
University of Washington Fred Hutchinson Cancer Research Center Brigham and Women's Hospital |
A Quantitative PET/CT Research Resource for Co-Clinical Imaging of Lung Cancer Therapies |
2021 |
| Osteosarcoma cancer | Heike Daldrup-Link* Daniel Rubin |
Stanford University |
Co-Clinical Research Resource for Imaging Tumor Associated Macrophages |
2021 |
| Pancreatic ductal adenocarcinoma cancer | Rong Zhou* Peter O’Dwyer Mark Rosen |
University of Pennsylvania | 2018 | |
| Small cell neuroendocrine prostate cancer | John Kurhanewicz* Donna Peehl Renuka Sriram |
University of California at San Francisco | 2020 | |
| Soft tissue sarcoma cancer | Cristian Badea* G. Allan Johnson |
Duke University |
The Duke Preclinical Research Resources for Quantitative Imaging Biomarkers |
2017 |
| Triple negative breast cancer | Kooresh Shoghi* Joseph Ackerman Shunqiang Li Richard Wahl |
Washington University | 2017 | |
| Triple negative breast cancer | Mike Lewis* Thomas Yankeelov Daniel Rubin |
Baylor College of Medicine University of Texas at Austin Stanford University |
2019 |
The CIRP Network
The CIRP Network comprises nine co-clinical imaging research resources and the relevant research resources provided by associate members.
The CIRP Network Mission
The mission is to advance precision medicine by establishing and disseminating consensus-based best practices for co-clinical imaging and by developing optimized state-of-the-art quantitative imaging methodologies for disease detection, risk stratification, and therapeutic response assessment.
The CIRP Network Structure
The CIRP Network includes a steering committee, CIRP teams, working groups (WGs), and associate members. The WGs include:
- Animal Models and Co-Clinical Trials
- Imaging Acquisition and Data Process
- Informatics and Outreach
CIRP invites academic investigators who are not funded by CIRP to join the network as associate members. The associate members contribute expertise and efforts to the WGs, to expand the scientific scope of the network and help achieve a broad consensus on co-clinical imaging.
How to Join the CIRP Network as an Associate Member
The CIRP Network invites NCI and NIH-supported academic investigators to join as associate members. The network is looking for investigators with expertise in animal models (GEMMs or PDXs), co-clinical therapeutic trials, quantitative imaging in the preclinical and clinical settings, and informatics technology.
As an associate member, you can contribute to developing a consensus on co-clinical imaging issues, expansion of CIRP’s scientific scope, and acceleration of the dissemination of CIRP resources. Please see the Solicit Associate Members and the mission statement of Working Groups.
CIRP Annual Meetings
CIRP organizes annual meetings and meeting sessions at scientific conferences or meetings by other NCI programs.
CIRP’s annual meeting is open to the public with no registration fee. CIRP has a home page at the NCI Wiki site, which is a workspace for intra-network communications and scientific discussions and a website where you can share publicly accessible information, news/events, and CIRP web resources.
Contact
Dr. Huiming Zhang (zhanghui@mail.nih.gov)