Clinical Trials Branch

• Awarding grants and contracts to extramural investigators for exploratory trials
• Advising and providing a strategic roadmap for imaging research in the extramural imaging community via a leadership role in the Clinical Imaging Steering Committee (CISC)
• Providing guidance for NCI-sponsored clinical trials through review of Cancer Therapy Evaluation Program (CTEP)-sponsored protocols that have imaging as a scientific objective
• Helping to promote standardization of imaging used in NCI-sponsored clinical trials by helping to establish and advise the Imaging and Radiation Oncology Core (IROC) as part of the National Clinical Trials Network (NCTN)
• Overseeing the development of imaging in trials conducted through NCI’s Experimental Therapeutics Clinical Trials Network (ETCTN)
• Integrating quantitative imaging tool testing and validation in clinical trials
• Identifying and facilitating clinical trial imaging data incorporation into a publicly available archive to enable discovery research
• Developing trial-related informatics
• Promoting the development of radiomics-based clinical
  support tools
• Integrating imaging data into NCI efforts such as the Cancer Moonshot^SM Biobank, Clinical Proteomic Tumor Analysis Consortium (CPTAC) and Applied Proteogenomics Organizational Learning and Outcomes (APOLLO) network programs

CTB oversees and directs all aspects of clinical trials evaluating imaging and image-guided interventions in the phase 0 to phase 3 setting. CTB’s overarching theme is to further evaluate imaging in cancer management. The branch serves as the primary CIP liaison with the NCI clinical trial system and ensures that the goals and priorities of both CIP and NCI for imaging are addressed in these activities.