Skip to main content
An official website of the United States government
Email

Toxicology and Pharmacology Branch (TPB) Resources

TPB Resources

The TPB plans and directs collaborative, extramural and contract-supported programs involved in anti-cancer drug discovery that:

  • develop methodologies to determine levels of drugs and/or their metabolites in relevant biological conditions.
  • determine the pharmacokinetic profile for drugs of interest across various species.
  • integrate pharmacological and biological effect data into the drug development process in order to minimize undesirable toxicity and to achieve effective drug levels.
  • characterize the toxicological profile of new and established anti-tumor and antiviral agents and their modes of action in appropriate experimental settings.
  • guide the development of special target organ toxicity assays.
  • provide assistance for the evaluation of toxicity for biological agents and experimental formulations.
  • evaluate the toxicity and safety measures for potential new vaccines to be used for immunization against cancer.
  • determine the mechanism of action for high priority anti-tumor agents within relevant biological settings.
  • conduct current literature surveillance for new toxicological and pharmacological evaluations which are applicable to the needs of the Institute.
  • summarize all pharmacology and toxicology data for the Division of Cancer Treatment and Diagnosis (DCTD) and make recommendations about target organ toxicity and safe starting doses for Phase I clinical trials.
  • provide pharmacological and toxicological inputs and assessments necessary for the preparation of Investigational New Drug Applications (IND) and Drug Master Files (DMF).
  • interact with other institute centers (ICs) to exchange information on preclinical pharmacology and toxicology data pertinent to formulating recommendations for doses, dose escalation schemes and treatment schedules for clinical trials.

If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “Toxicology and Pharmacology Branch (TPB) Resources was originally published by the National Cancer Institute.”

Email