Biometric Research Program

Green background with circles radiating and fading from the right. White text on the left states, “provides statistical and computational leadership for clinical trials, biostatistics, computational biology, and bioinformatics.”

The Biometric Research Program (BRP) at the National Cancer Institute (NCI) provides biostatistics and computational and systems biology support for staff with the Division of Cancer Treatment and Diagnosis (DCTD) and NCI intramural investigators. This support includes:

Statistical leadership and oversight for NCI therapeutic and diagnostic trials and translational research;
Research in methods for the design, monitoring, and analysis of clinical trials and related studies;
Developing bioinformatic systems to analyze and interpret genome-wide data;
Conducting research on mechanisms of carcinogenesis and systems biology;
Collaborating with other NCI clinical trials staff to analyze genomic data;
Conducting self-initiated research on topics important to cancer research.

About the Biometric Research Program (BRP)

About BRP
Contact BRP Staff
Computational and Systems Biology Branch (CSBB)
Collaborates in DCTD pre-clinical programs with genomic and proteomic data, research mechanisms of carcinogenesis and systems pharmacology, develops bioinformatic systems.
Biostatistics Branch (BB)
Statistical leadership and oversight for national DCTD programs, translational research, design and analysis of clinical trials.

Software Tools and Resources

tmbLab
This package generates and applies a calibration model as described in Phase 2 of the Friends of Cancer Research (FOCR) tumor mutational burden (TMB) harmonization project.
NCI Transcriptional Pharmacodynamics Workbench
The NCI Transcriptional Pharmacodynamics Workbench (NCI TPWB) gives scientists access to the genome-wide characterization of the NCI-60 cell lines and the enormous time-course databases on genome-wide response to treatment with drugs.
MutSpliceDB
MutSpliceDB documents mutation effect(s) on splicing (such as exon inclusion/exclusion or intron retention) based on RNA-seq BAM files from sample(s) with particular splice site mutations.

Check the full list of software developed by the Biometric Research Program on the BRP Software and Tools page.