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Active DTC Clinical Trials

Trial NameClinicaltrials.gov NCT Number
Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and PaclitaxelNCT04449549*
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People with Advanced Solid TumorsNCT03366116
Metarrestin (ML-246) in Subjects with Metastatic Solid TumorsNCT04222413
Nivolumab in Treating Patients with Autoimmune Disorders and Advanced, Metastatic, or Unresectable CancerNCT03816345
Durvalumab in Combination with Chemotherapy in Treating Patients with Advanced Solid Tumors, DURVA+ TrialNCT03907475
Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical NeurofibromasNCT04750928
Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients with Tumors That Have Alterations in DNA Repair GenesNCT05687110
Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and Tuvusertib (M1774) for Advanced Solid TumorsNCT05687136
Studying TAK-243 in Patients with Advanced CancerNCT06223542
Testing How the Body Responds to the Drug CX-5461 (Pidnarulex) in Patients with Metastatic Solid CancersNCT06606990
Targeted Therapy Directed by Genetic Testing in Treating Patients with Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening TrialNCT05564377
A Phase 2 Study of Atezolizumab with Selinexor in Alveolar Soft Part Sarcoma (AXIOM)NCT05333458
Phase 2 Trial of the Combination of the BET Inhibitor, ZEN003694 (ZEN-3694), and the PARP Inhibitor Talazoparib, in Patients with Molecularly Selected Solid Tumors (ComBET)NCT05327010
Pilot Study of CBX-12 Pharmacodynamics in Patients with Advanced Solid TumorsNCT05691517
Randomized Trial of Neratinib, a Pan-ErbB Inhibitor Alone or in Combination with Palbociclib, a CDK4/6 Inhibitor, in Patients with HER2+ Gynecologic Cancers and Other Solid Tumors (ComboMATCH Treatment Trial N5)NCT06126276

*Study is open only for the following histologic subtypes: clear cell ovarian cancer, anal cancer, granulosa cell ovarian cancer, and ewing sarcoma
** Prior PARP required

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