Brian S. Sorg, Ph.D., M.B.A.

As Chief of the Diagnostic Biomarkers and Technology Branch (DBTB), Dr. Sorg supervises branch staff in the management of the branch grant portfolio, development of research initiatives, and participation in collaborative efforts across the NCI, NIH, and other Federal agencies. Dr. Sorg’s grant portfolio includes projects related to liquid biopsies, microfluidics, tissue chips, in vitro optical imaging, and biosensors for applications in cancer diagnosis and treatment.

Dr. Sorg joined the NCI and DCTD as a Program Director in DBTB in 2012. Prior to joining NCI, Dr. Sorg was an Assistant Professor in the J. Crayton Pruitt Family Department of Biomedical Engineering at the University of Florida in Gainesville. His research focused on in vivo spectral imaging microscopy of tumor microvasculature to measure oxygen delivery effects of anti-vascular targeting therapies.

Dr. Sorg did his post-doctoral training at Duke University Medical Center in the laboratory of Dr. Mark W. Dewhirst, DVM, PhD. He performed research on tumor hypoxia and microvascular oxygen transport in mouse models.

Selected Publications

• Sorg BS, Byun JS, Westbrook VA, Tricoli JV, Doroshow JH, Harris LN. NCI workshop on ctDNA in cancer treatment and clinical care. Journal of the National Cancer Institute 2024, 116(12): 1890-1895.
• Lee JA, Kozikowski RT, Sorg BS. In vivo microscopy of microvessel oxygenation and network connections. Microvascular Research 2015; 98: 29-39.
• Choe S, Terman DS, Rivers AE, Rivera J, Lottenberg R, Sorg BS.  Drug-loaded sickle cells programmed ex vivo for delayed hemolysis target hypoxic tumor microvessels and augment tumor drug delivery.  Journal of Controlled Release 2013, 171: 184-192.
• Wankhede M, Agarwal N, Fraga-Silva RA, Casey Dedeugd, Raizada MK, Oh SP, Sorg BS. Spectral imaging reveals microvessel physiology and function from anastomoses to thromboses. Journal of Biomedical Optics 2010, 15(1): 011111.
• Sorg BS, Moeller BJ, Donovan O, Cao Y, Dewhirst MW.  Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development.  Journal of Biomedical Optics 2005; 10(4): 44004.

Additional Links to Scientific Publications

• Google Scholar

Education

• MBA, University of North Carolina, Chapel Hill, NC
• PhD, Biomedical Engineering, University of Texas, Austin, TX
• MS, Biomedical Engineering, Johns Hopkins University, Baltimore, MD
• BS, Electrical Engineering, University of Maryland, College Park, MD