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Last Updated: 02/23/2024

Careers in the Division of Cancer Treatment and Diagnosis

DCTD takes prospective detection and treatment leads, facilitates their paths to clinical application, and expedites the initial and subsequent large-scale testing of new agents, biomarkers, imaging tests, and other therapeutic interventions (radiation, surgery, immunotherapy) in patients. The division has nine major programs that work together to bring unique molecules, diagnostic tests, and therapeutic interventions from the laboratory bench to the patient bedside. Job opportunities in these programs are detailed below. For additional information on DCTD and our career opportunities follow our division’s LinkedIn page. External Link

Information on DCTD Federal Job Opportunities

All scientific, administrative, and clinical federal positions in DCTD are listed below.

As part of our workforce recruitment efforts, DCTD is committed to Diversity, Equity, Inclusion, and Accessibility and providing a safe work environment for staff in our nine major programs that work together.

DCTD posts opportunities ahead of the official vacancy announcements on USAJobs.gov, where all federal positions must be posted. Interested applicants must apply for federal positions through USAJobs.
NOTE: Most positions are only open for a period of 5 business days.

Please create an account on USAJobs and set up alerts to be notified when these vacancy announcements become available. Further instructions can be found on the USAJobs web site.

Clinical Trials

CIRB Expert

The NCI is recruiting for a Central Institutional Review Board (CIRB) Expert in the Clinical Trials Operations and Informatics Branch (CTOIB), Cancer Therapy Evaluation Program (CTEP), DCTD, NCI, part of the National Institutes of Health (NIH). DCTD is an extramural division of NCI. This is a full-time government position in Rockville, Maryland.

The NCI sponsors and funds a broad range of clinical trials for children and adults with cancer through a variety of clinical trials groups and consortia. Through these programs, NCI works collaboratively with clinical investigators in NCI-funded clinical trial networks, often in collaboration with pharmaceutical industry partners, to optimize the development of cancer treatments in the public interest and to increase understanding of the cancers being studied. CTOIB coordinates the development, implementation, and conduct of all clinical trials management processes and informatics tools specific to the operations of CTEP's overall clinical trials portfolio. The broad scientific reach of this nationwide program requires that CTOIB staff interact with multiple NCI programs, including National Clinical Trials Network (NCTN), Experimental Therapeutics Clinical Trials Network (ETCTN), NCI Community Oncology Research Program (NCORP), Cancer Centers, and specialized Consortia grantees. This coordination role of CTOIB extends across NCI Divisions and Centers to involve all major NCI Divisions (especially DCP and DCCPS), CCT, and CBIIT, and the Cancer Centers program. CTOIB staff interacts frequently with the lead investigators and administrative staff within networks and consortia, especially the Clinical Trials Cooperative Group Program. The Cooperative Group Program enrolls approximately 25,000 patients annually and provides a mechanism for the continuous generation of therapeutic and ancillary studies with the intent of improving the survival and quality of life of patients afflicted with cancer in the U.S. and worldwide.

Since 1999, CTEP has been responsible for creating and managing the NCI CIRB. The CIRB was created to reduce the redundant and costly Institutional Review Board (IRB) review of multi-center phase 3 Cooperative Group trials by centralizing the review function in a single Review Board, while maintaining an excellent standard of human subjects' protection. The CIRB is a complex project that involves over 300 sites across the U.S. The candidate will:

  • Serve as Senior Health Scientist with overall responsibility for the development, implementation, and daily operation of the CIRB initiative.
  • Serve as a technical authority, senior advisor, and consultant in the field of clinical research and human subjects protection.
  • Serve as the principal resource in the office of the NCI CIRB in developing research policy, particularly, in the area of protecting the human subjects of research.
  • Be responsible for conceiving, formulating, and establishing criteria and objectives that ensure CIRB accreditation.
  • Provide leadership, expert advice, and direction on accreditation program requirements and procedures.
  • Plan and conduct program reviews to evaluate the effectiveness of the contract to ensure that it meets the criteria and is in compliance with regulations and laws.
  • Serve on committees established to review proposed regulations, guidelines, and procedures

Access CTOIB’s website: https://ctep.cancer.gov/branches/pio/default.htm

Qualifications
Candidates must be US citizens and have successfully completed a bachelor's or graduate/higher level degree with major study in an academic field related to the medical field, health sciences, or allied sciences appropriate to the work of the position. Skills in advising, serving as a recognized authority and consultant, and providing direction and guidance to major initiatives affecting the NCI clinical trials program; advanced skills in the regulations and best practices associated with the management and operations of IRBs for biomedical research programs, and specifically those involving cancer treatment and development; and knowledge of clinical research, especially as it relates to the design and conduct of clinical trials, including knowledge of current oncologic therapeutics, disease sites, drug therapy, drug toxicities, patient management, and investigational therapies, are desired.

Salary will be commensurate with experience. A full civil service package of benefits (including health insurance, life insurance, and retirement) is available.

How to Apply
Interested candidates should contact Mike Montello (montellom@mail.nih.gov) with questions regarding this position.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

Data Scientists, Statisticians, IT

Medical Bioinformatician

The Office of the Director (OD), DCTD, NCI is seeking an experienced and self-motivated candidate to fill a Biomedical Informatician vacancy.

The DCTD expedites the pre-clinical development and subsequent large-scale clinical testing of new agents, biomarker assays, imaging modalities, and other therapeutic interventions (radiation, surgery, immunotherapy) in patients. The DCTD has nine major programs work together to bring unique molecules, diagnostic tests, and therapeutic interventions from the laboratory bench to the patient bedside and back.

The successful candidate will serve as a Biomedical Informatician in DCTD, with responsibility for working with other government and contract biomedical, informatics, statistical and clinical experts to conceive, plan, develop, implement, and evaluate biomedical informatics solutions to address existing and future clinical and pre-clinical cancer research requirements.

Expertise and knowledge in biomedical informatics to manage projects involving the development of informatics solutions that support cancer clinical research programs and initiatives, is desired.

Qualifications
Applicants must be U.S. citizens, with a Bachelor's or graduate/higher level degree in a major study in an academic field related to bioinformatics, data science, computer science, or health/allied sciences appropriate to the work of the position.

Experience in:

  • Developing software, databases, or portals that collect, process, store, integrate and perform computational analysis of biomedical data, particularly coming from multiple sources
  • Identifying program needs and translating them into biomedical informatics solutions
  • Evaluating the performance of existing biomedical informatics technology systems and programs relative to current and future requirements
  • Developing and implementing pipelines to receive, assess, process and store data in systems; developing standard operating procedures for the acquisition, integration and analysis of clinical trial data, including laboratory and research assay results, multi-omics data, treatment and biospecimen collection/processing timelines, costs
  • Participating in the administration of biomedical informatics contracts

This is a full-time Federal Government position, located in Bethesda and Rockville, MD. Compensation for the position is commensurate with the individual's qualifications and experience, as permitted with Federal Government appointments.

How to Apply
This is an exploratory ad to gauge interest and a possible candidate pool. The vacancy announcement to fill this position will be posted on: usajobs.gov at a later date.

Contact for Interested Candidates

Michael Difilippantonio, PhD
difilipm@mail.nih.gov

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

Health Science Administrators

Health Science Administrators

DCTD, NCI is seeking to fill multiple vacancies for Health Scientist Administrators in the following DCTD Programs:

As a Health Scientist Administrator, the incumbent will perform a wide variety of duties and responsibilities relating to the administration of a large research grants program involving basic, translational, and clinical studies:

  1. Perform scientific and administrative reviews and analyses of applications/proposals from a programmatic viewpoint
  2. Consult with and advise grantees/contractors during preparation of applications/proposals and following reviews, and provide guidance on program issues
  3. Develop, coordinate, and administer grants, cooperative agreements, and contracts established to fulfill the mission of the Branch and Division.

Some travel to universities, research institutions, commercial organizations, other government agencies, entrepreneur/innovation centers, and public and private organizations to promote and explain the objectives of the program may be necessary.

CDP strives to improve the diagnosis and assessment of cancer by effectively moving new scientific knowledge into clinical practice. CDP coordinates and funds resources and research for the development of innovative in vitro diagnostics, novel diagnostic technologies and appropriate human specimens to better characterize cancers and allow improved medical decision making and evaluation of response to treatment.

CIP’s mission is to promote and support cancer-related basic, translational and clinical research in imaging sciences and technology, and integration and application of these imaging discoveries and developments to the understanding of cancer biology and to the clinical management of cancer and cancer risk.

CTEP’s mission is to improve the lives of cancer patients by finding better ways to treat, control and cure cancer. CTEP accomplishes this mission by funding an extensive national program of cancer research and by sponsoring clinical trials to evaluate new anti-cancer agents and combinations, with a particular emphasis on translational research to elucidate molecular targets and mechanisms of drug effects.

RRP manages NCI’s support for research across the radiation sciences spanning clinical trials, combined modality radiotherapy, experimental therapeutics, radiation treatment planning, radiobiology, physics, and technology. RRP establishes priorities, allocates resources, and evaluates the effectiveness of radiation research being conducted by NCI grantees.

Through its SPORE Program (Specialized Programs of Research Excellence), TRP is committed to reducing cancer incidence and mortality and improving survival and quality of life for cancer patients. TRP uses advances in basic sciences to develop new approaches for the diagnosis and treatment of cancer by fostering interdisciplinary investigations and coordinating the resources of NCI with those of academia, industry, and nonprofit organizations and foundations.

Qualifications
Applicants must meet the following minimum educational requirement: completion of a bachelor’s or graduate/higher level degree with major study in an academic field related to the medical field, health sciences or allied sciences appropriate to the work of the position. Additional specialized experience will be required and will be outlined in the vacancy announcement, when posted at a later date. Read more about the required qualifications of a Health Scientist Administrator.

These are full-time Federal Government positions located in Rockville, Maryland. Applicants must be U.S. Citizens. Compensation for these positions is commensurate with the individual's qualifications and experience, as permitted with Federal Government appointments.

How to Apply

  1. Interested candidates should submit a letter of interest and CV via email to the relevant contact below:
    CDP: Dr. Brian Sorg; Brian.Sorg@mail.nih.gov
    CIP: Dr. Michael Espey; michael.espey@nih.gov
    CTEP: Dr. Lori Henderson; hendersonlori@mail.nih.gov
    RRP: Dr. C. Norman Coleman; ccoleman@mail.nih.gov
    TRP: Dr. Peter Ujhazy; ujhazyp@mail.nih.gov
  2. To be considered as a candidate for these positions, you must apply to a vacancy announcement when it becomes available on WWW.USAJOBS.GOV at a later date.

    The NIH Global Recruitment Announcements are posted three times per year. Please see the NIH Office of Human Resources website.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

Physicians

Adult Oncology, Clinical Investigations Branch

DCTD’s Cancer Therapy Evaluation Program (CTEP), Clinical Investigations Branch (CIB), is seeking a candidate for the position of Physician.

Responsibilities
The scope of activities that CTEP/CIB oversees includes:

  • Coordinates the disease-oriented clinical trials research development program of the DCTD, NCI
  • Develops and evaluates multi-modality anticancer therapies through the sponsorship of clinical trials
  • Responsible for the majority of extramural, NCI-sponsored cancer treatment clinical trials conducted in the United States, largely through interactions with investigators within NCI-sponsored Clinical Trials Networks, as well as other clinical trial organizations and consortia
  • Participates in developing the research projects preparatory to phase 3 studies, including phase 1, 2, pilot and laboratory-translational trials in conjunction with other components of CTEP
  • Extensively interacts with the CTEP Investigational Drug Branch, DCTD Cancer Imaging Program, DCTD Cancer Diagnosis Program, extramural and intramural clinical investigators, NCI-sponsored Clinical Trials Networks, and other NCI Divisions
  • Opportunities for continued patient care, teaching, and direct participation in clinical research are available.

Qualifications

  • Experience in the conduct of clinical research for adults with cancer
  • An active medical license
  • A clinical background and training in a relevant oncology sub-specialty (such as medical, radiation, gynecologic, or surgical oncology, etc.)
  • Experience of phase 1,2, and 3 clinical trials, cancer biology, pharmacology, and clinical trial designs.

Candidates must be U.S. citizens.

Applicants must meet the minimum educational and training requirements set by the U.S. Office of Personnel Management (OPM) for the Medical Officer Series (0602). Additional specialized experience will be required and will be outlined in the vacancy announcement, when posted at a later date.

How to Apply
This is an exploratory ad to gauge interest and develop a possible candidate pool.

Interested candidates should send their resumes to NCIDCTDvacancyinquiry@mail.nih.gov, or contact Dr. Maragret Mooney at: 240-276-6006, with questions regarding this position.

To be considered as a candidate for this position, you must apply to the vacancy announcement for a Physician (Clinical), GP-602-15, when it becomes available on WWW.USAJOBS.GOV at a later date.

The NIH Global Recruitment Announcements are posted three times per year. Please see the NIH Office of Human Resources website.

This is a full-time government position in Rockville, Maryland. Compensation for this position is commensurate with the individual’s qualifications as permitted within Federal Government appointments.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

Pediatric Oncology, Clinical Investigations Branch

DCTD’s Cancer Therapy Evaluation Program (CTEP), Clinical Investigations Branch (CIB), is seeking a candidate for the position of Physician.

Responsibilities

  • Oversee a pediatric cancer clinical trials portfolio focusing on the incorporation of new molecular characterization and novel therapeutic strategies into clinical trials for children and adolescents with cancer
  • Provide oversight for a clinical research portfolio for selected childhood cancers
  • Support projects and programs directed at the optimal prioritization of novel agents and new treatment approaches for evaluation in children with cancer and for then overseeing implementation of the resulting clinical trials; the prioritization process includes internal CTEP review meetings, as well reviews conducted by the Disease Steering Committees (SC) relevant for childhood cancers (i.e., the Pediatric Leukemia Lymphoma SC, the Pediatric and Adolescent Solid Tumor SC, and the Brain Malignancy SC)
  • Serve as a scientific liaison for pediatric cancer research to CTEP grantees (e.g., Children’s Oncology Group (COG) Disease Committees) and for other organizations with which CTEP interacts to accomplish its pediatric cancer research mission (e.g., pharmaceutical companies, patient advocacy organizations, and regulatory agencies)
  • May coordinate and participate in NCI-supported trans-Division scientific initiatives such as the Childhood Cancer Data Initiative, the Pediatric Immunotherapy Network, the Targeting Fusion Oncoproteins in Childhood Cancers Network, and others

The scope of activities that NCI/DCTD/CTEP/CIB oversees includes:

  • Sponsors and funds a broad range of clinical trials for children, adolescents, and adults with cancer through a variety of clinical trials groups and consortia
  • Works collaboratively with clinical investigators in NCI-funded clinical trial networks, often in collaboration with pharmaceutical industry partners, to optimize the development of cancer treatments in the public interest, and to increase understanding of the cancers being studied
  • Coordinates and oversees the NCI’s National Clinical Trials Network Program (NCTN), which includes COG, plus the Pediatric Brain Tumor Consortium (PBTC), the Pediatric Early Phase Clinical Trials Network (PEP-CTN), the Childhood Cancer Survivor Study (CCSS), and the Pediatric Preclinical in Vivo Testing (PIVOT) program
  • Facilitates and supports clinical research, including surgical and radiation therapy, as well as chemo-, biologic- and immuno-therapies in the treatment of cancer

Qualifications

  • An active medical license
  • A clinical background with board certification in pediatric hematology/oncology
  • Experience with the biology and genomics of childhood cancers, clinical trial design, and the development of novel therapies in the pediatric oncology setting

Candidates must be U.S. citizens.

Applicants must meet the minimum educational and training requirements set by the U.S. Office of Personnel Management (OPM) for the Medical Officer Series (0602). Additional specialized experience will be required and will be outlined in the vacancy announcement, when posted at a later date.

How to Apply
Interested candidates should contact Dr. Malcolm Smith (Malcolm.Smith@nih.gov) or Dr. Nita Seibel (seibelnl@nih.gov) with questions regarding this position.

To be considered as a candidate for these positions, you must apply to a vacancy announcement when it becomes available on WWW.USAJOBS.GOV at a later date.

The NIH Global Recruitment Announcements are posted three times per year. Please see the NIH Office of Human Resources website.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

Supervisory Physician (Branch Chief), Investigational Drug Branch

DCTD’s Cancer Therapy Evaluation Program (CTEP), Investigational Drug Branch (IDB), is seeking a candidate for the position of Supervisory Physician (Branch Chief).

Responsibilities

  • Is vitally important to DCTD because clinical trials are NCI’s primary interface with the public, with Congress, and with patients
  • Implements and oversees a portfolio of novel cancer agents in an innovative, investigational experimental therapeutics program
  • Makes daily decisions that are critical to how trials are conducted, which cancers are prioritized, which agents are selected for development in NCI’s national and international networks, and what resources (financial and personnel) are committed to them
  • Is a highly capable and experienced leader to carry out the following duties:
    • Advising the Associate Director, CTEP, and Director, DCTD in all matters pertaining to NCI drug development
    • Advising leaders in the Developmental Therapeutics Program, DCTD on the appropriate preclinical experiments in animal models to guide human trials in the IDB
    • Guiding the interactions with pharmacologists, pathologists and translational scientists at the Frederick Research Labs, NCI, to develop, validate, and conduct human trials using pharmacodynamic and other types of biomarkers
    • Serving as the primary spokesperson for the IDB at weekly CTEP Protocol Review Committee and Biomarker Review Committee meetings to decide which studies will be conducted by NCI/CTEP-funded trial networks
    • Representing the IDB at meetings with pharmaceutical and biotech company representatives to review their drug pipelines and to establish collaborations
    • Representing the NCI to the external national and international community at CTEP’s bi-monthly meetings with the Food and Drug Administration, displaying a leadership role at educational sessions at national meetings, such as ASCO and AACR, and responding expertly to queries from HHS, NIH, Congress, and patient advocacy groups

The scope of activities that CTEP/IDB oversees includes:

  • Sponsors and funds clinical trials of novel anti-neoplastic agents that have been approved for NCI-sponsored development (NCI-IND agents)
  • Works collaboratively with clinical investigators in NCI-funded clinical trial networks and with pharmaceutical industry partners to optimize the development of these anti-cancer drugs in the public interest
  • Implements and provides subsequent pharmacovigilance monitoring for this wide-reaching oncology early drug development program
  • Together with CTEP colleagues, shapes the clinical research development of NCI-IND agents and shepherds clinical research proposals through the scientific and regulatory hurdles necessary for the conduct of human trials
  • Supports translational and clinical research of NCI-IND agents primarily through the Experimental Therapeutics Clinical Trials Network (ETCTN), as well as other NCI-funded clinical trial networks.

Qualifications

  • Experience in the conduct of clinical research for adults with cancer
  • An active medical license
  • A clinical background and training in a relevant oncology sub-specialty (such as medical oncology, pediatric oncology, etc)
  • Experience of phase 1,2, and 3 clinical trials, cancer biology, pharmacology, clinical trial design, and the development of investigational anti-cancer drugs.

Candidates must be U.S. citizens.

Applicants must meet the minimum educational and training requirements set by the U.S. Office of Personnel Management (OPM) for the Medical Officer Series (0602). Additional specialized experience will be required and will be outlined in the vacancy announcement, when posted at a later date.

How to Apply
This is an exploratory ad to gauge interest and develop a possible candidate pool.

Interested candidates should send their resumes to NCIDCTDvacancyinquiry@mail.nih.gov, or contact Dr. Maragret Mooney at: 240-276-6006, with questions regarding this position.

To be considered as a candidate for this position, you must apply to the vacancy announcement for a Physician (Clinical), GP-602-15, when it becomes available on WWW.USAJOBS.GOV at a later date.

The NIH Global Recruitment Announcements are posted three times per year. Please see the NIH Office of Human Resources website.

This is a full-time government position in Rockville, Maryland. Compensation for this position is commensurate with the individual’s qualifications as permitted within Federal Government appointments.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

Physician — Investigational Drug Branch

DCTD’s Cancer Therapy Evaluation Program (CTEP), Investigational Drug Branch (IDB), is seeking a candidate for the position of Physician.

The mission of CTEP is to improve the lives of cancer patients by finding better ways to treat, control and cure cancer. CTEP accomplishes this mission by funding an extensive national program of cancer research and by sponsoring clinical trials to evaluate new anti-cancer agents, with a particular emphasis on translational research to elucidate molecular targets and mechanisms of drug effects. IDB implements and oversees portfolios of novel cancer agents in an innovative investigational experimental therapeutics program.

Qualifications
Applicants must meet the minimum educational and training requirements set by the U.S. Office of Personnel Management (OPM) for the Medical Officer Series (0602). Additional specialized experience will be required and will be outlined in the vacancy announcement, when posted at a later date.

This is a full-time government position in Rockville, Maryland. Compensation for this position is commensurate with the individual’s qualifications and experience as permitted within Federal Government appointments.

How to Apply
This is an exploratory ad to gauge interest and a possible candidate pool. To be considered as a candidate for this position, you must apply to a vacancy announcement when it becomes available on WWW.USAJOBS.GOV.

The NIH Global Recruitment Announcements are posted three times per year. Please see the NIH Office of Human Resources website.

Interested candidates should contact Dr. Steven Gore: steven.gore@nih.gov.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

Physician — Developmental Therapeutics Clinic

DCTD’s Developmental Therapeutics Clinic (DTC) in the Office of the Director is seeking a candidate for the position of Physician.

The goal of DTC is to develop new treatments for patients with advanced cancer through innovative early phased clinical trials. Each year patients from around the world with cancers that have relapsed after standard treatment visit DTC for consultation about participation in the innovative new treatment trials conducted at NIH. DTC participates in the Experimental Therapeutics Clinical Trials Network (ETCN) and supports the work of the DCTD.

Qualifications
Applicants must meet the minimum educational and training requirements set by the U.S. Office of Personnel Management (OPM) for the Medical Officer Series (0602). Additional specialized experience will be required and will be outlined in the vacancy announcement, when posted at a later date.

This is a full-time government position in Rockville, Maryland. Compensation for this position is commensurate with the individual’s qualifications and experience as permitted within Federal Government appointments.

How to Apply
This is an exploratory ad to gauge interest and a possible candidate pool. To be considered as a candidate for this position, you must apply to a vacancy announcement when it becomes available on WWW.USAJOBS.GOV.

The NIH Global Recruitment Announcements are posted three times per year. Please see the NIH Office of Human Resources website.

Interested candidates should contact Dr. Alice Chen Alice.Chen@nih.gov.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

Scientific Positions

Branch Chief, Drug Synthesis and Chemistry Branch

DCTD’s Developmental Therapeutics Program (DTP) is seeking a candidate for the position of Branch Chief, Drug Synthesis and Chemistry Branch (DSCB).

Responsibilities

  • Directs activities of the DSCB
  • Collaborates with investigators in DTP
  • Manages and coordinates all functional requirements for the branch, including comprehensive chemistry services to supply DCTD with high-quality chemical substances through a chemical preparation laboratory and contracted services
  • Directs contract research that provides analytical services, product research and development of dosage forms, large-scale pharmaceutical manufacturing, and shelf-life assessment of the finished dosage forms
  • Manages and coordinates a system of contracts to synthesize and bring experimental cancer therapies to initial clinical trials in collaboration with intramural and extramural investigators

The scope of activities that DCSB oversees includes:

  • Acquiring novel chemical entities — synthetic and natural — and diversity set compound libraries for evaluation as potential cancer therapy agents and developing new areas of medicinal and organic chemistry amenable to product scale-up
  • Acquiring structurally and biologically diverse compounds, principally from academic researchers, but also submitted by investigators from research institutes, government laboratories, and the private sector
  • DSCB chemists who manage compound synthesis/scale-up projects for preclinical and clinical research and conduct research to optimize synthetic schemes
  • Development and manufacture of agents (small molecule and natural products)

Qualifications
Candidates must have a degree in physical sciences, life sciences, or engineering that included 30 semester hours in chemistry, supplemented by course work in mathematics through differential and integral calculus, and at least 6 semester hours of physics.

Candidates must be U.S. citizens.

Compensation for this position is commensurate with the individual’s qualifications and experience as permitted within Federal Government appointments.

How to Apply
This is an exploratory ad to gauge interest and a possible candidate pool. The vacancy announcement to fill these positions will be posted on: usajobs.gov at a later date.

Prospective applicants should also express their interest to Dr. Rosemarie Aurigemma — aurigemr@nih.gov — Associate Director, Developmental Therapeutics Program, DCTD, NCI

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

Molecular Pharmacologist

The DCTD, NCI is seeking a candidate with a strong interest in studying pharmacological mechanisms of action (MOA) to fill a Molecular Pharmacologist vacancy.

The candidate will collaborate with investigators in the Developmental Therapeutics Program (DTP) by serving as an experimental pharmacologist in the Molecular Pharmacology Branch (MPB).

Responsibilities

  • Providing skills in the design and management of research
  • Advising other professionals regarding preclinical support for clinical trials involving anticancer drug and biological agents and for the progression of unique compounds through the agent screening and drug development process
  • Developing, designing, and implementing MOA studies for testing various therapeutics based on patient, in vivo, or in vitro model-derived observations
  • Interacting with DCTD staff on general matters pertaining to MOA

Qualifications

  • This is a full-time Federal Government position.
  • Applicants must be U.S. citizens.
  • Compensation is commensurate with the candidate's qualifications and experience.
  • Candidates must meet the following minimum educational requirement: Completion of a bachelor's or graduate/higher level degree with major study in an academic field related to the medical field, health sciences or allied sciences appropriate to the work of the position.
  • Significant experience with hands-on laboratory molecular pharmacology enablement is desired.
  • Additional specialized experience will be required and will be outlined in the vacancy announcement when it is posted at a later time.

How to Apply
This is an exploratory ad to gauge interest and a possible candidate pool. The vacancy announcement to fill this position will be posted on www.usajobs.gov at a later date.

Interested candidates may send a letter of application, curriculum vitae, and complete contact information for three references to:

Christophe Marchand, PhD
Deputy Associate Director
Developmental Therapeutics Program, DCTD
marchanc@mail.nih.gov

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

Pharmacologist

DCTD’s Developmental Therapeutics Program (DTP), Toxicology and Pharmacology Branch, is seeking a candidate for the position of Pharmacologist.

Responsibilities

  • Coordinates and evaluates safety testing of investigational cancer therapies, including biopharmaceutical agents used in multiple research studies
  • Develops and evaluates research protocols for appropriateness of study design and the use of pharmaceutical information
  • Develops pharmacokinetic study design initiatives
  • Assists in all phases of contract solicitation, including review and award for pharmacology studies
  • Evaluates and interprets pharmacological data from both nonclinical and clinical studies

Qualifications
NCI is seeking candidates with a degree in the field of pharmacology or an appropriate discipline of the biological, medical, or veterinary sciences that includes at least 30 semester hours in chemistry and physiology, and 12 semester hours in pharmacology.

Candidates must be U.S. citizens.

Compensation for this position is commensurate with the individual’s qualifications and experience as permitted within Federal Government appointments.

How to Apply
This is an exploratory ad to gauge interest and a possible candidate pool. The vacancy announcement to fill these positions will be posted on: usajobs.gov at a later date.

Prospective candidates should express their interest to:

Elizabeth R. Glaze, PhD, DABT
Chief, Toxicology and Pharmacology Branch
Developmental Therapeutics Program, DCTD
glazee@mail.nih.gov

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

Postdoctoral Fellowship

DCTD is inviting qualified applications for a postdoctoral research position in the area of cancer therapeutics. The candidate will:

  • Perform basic research on nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mediated signaling mechanisms in cancer therapeutics
  • Investigate the role of reactive oxygen species (ROS) in the regulation of gene expression, signal transduction, and proliferation in human tumor cell systems, genetically engineered mouse models (GEMMs), as well as clinical samples.

This research effort also focuses on the development of small molecule and antibody inhibitors targeting reactive oxygen-generating epithelial tumor cell NADPH oxidases, with a special emphasis on mouse tumor models, including standard cell line xenografts, patient-derived tumor models, and GEMMs developed to understand the role of inflammatory stress on the control of NADPH oxidases, tumor initiation, and progression.

We are seeking a highly motivated individual with demonstrated scientific productivity to join the DCTD. Experience in eukaryotic molecular pharmacology, signal transduction, and the development of GEMMs is required; expertise in cell- and in vivo-based molecular pharmacodynamics and free radical biology is also desirable.

Qualifications
The ideal candidate will have a PhD in biochemistry, molecular/tumor biology, or related disciplines and preferably prior experience in the use of both in vitro and in vivo tumor models. Communication skills and the ability to collect, analyze, compile, and communicate complex scientific data both verbally and in writing is an essential prerequisite for this position. Salary is commensurate with research experience and accomplishments.

How to Apply
Please send an application package, with your resume/CV and other supporting documentation to:

Monika Sarna, Administrative Officer
Office of the Director, DCTD
Room 3A44, Building 31
31 Center Drive
National Cancer Institute, NIH
Bethesda, MD 20892
msarna@mail.nih.gov

This position is subject to a background investigation.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.