Careers in the Division of Cancer Treatment and Diagnosis

The Biostatistics Branch within the Biometric Research Program (BRP), DCTD, NCI is seeking an experienced candidate to fill a Mathematical Statistician vacancy.

Responsibilities

• Coordinate with DCTD senior staff in the development and review of national clinical trials evaluating new therapeutics and diagnostics
• Conduct research on statistical issues arising in clinical and translational science (clinical trial design, management and analysis, diagnostics development, and other important topics related to cancer research)
• Serve as a member of BRP and collaborate with NCI investigators in DCTD's Cancer Therapy Evaluation Program, Cancer Imaging Program, Cancer Diagnosis Program, and potentially other programs including the NCI Center for Cancer Research

The scope of activities that the Biostatistics Branch oversees includes:

• Statistical leadership and oversight for the national program of therapeutic and diagnostic clinical trials of NCI
• Translational research in developmental therapeutics, diagnostics, and cancer imaging
• Development, evaluation, and application of state-of-the-art methods for the design, monitoring, and analysis of clinical trials evaluating new therapeutics and precision medicine approaches
• Support of NCI's overall mission via enhancing the rate of promising scientific discoveries, and efficiency of their translation, to advance clinical care to reduce the burden of cancer in the US and around the world

Qualifications

Candidates:

• must have a doctorate degree in Statistics, Biostatistics, or equivalent.
• with experience in clinical trial design and molecular and imaging characterization of cancer are encouraged to apply.
• must be U.S. citizens.

This is a full-time Federal Government position, located in Bethesda and Rockville, MD. Compensation for the position is commensurate with the individual's qualifications and experience, as permitted with Federal Government appointments.

How to Apply

This is an exploratory ad to gauge interest and a possible candidate pool. The vacancy announcement to fill this position will be posted on www.usajobs.gov at a later date.

Interested candidates should submit a curriculum vitae and a statement of interest to:
Lisa McShane, PhD
lm5h@nih.gov
Include "BRP Math Stat Position" in the subject line.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

DCTD, NCI is seeking to fill multiple vacancies for Health Scientist Administrators in the following DCTD Programs:

• Cancer Therapeutics Evaluation Program (CTEP)
• Radiation Research Program (RRP)
• Translational Research Program (TRP)

As a Health Scientist Administrator, the incumbent will perform a wide variety of duties and responsibilities relating to the administration of a large research grants program involving basic, translational, and clinical studies:

1. Perform scientific and administrative reviews and analyses of applications/proposals from a programmatic viewpoint
2. Consult with and advise grantees/contractors during preparation of applications/proposals and following reviews, and provide guidance on program issues
3. Develop, coordinate, and administer grants, cooperative agreements, and contracts established to fulfill the mission of the Branch and Division.

Some travel to universities, research institutions, commercial organizations, other government agencies, entrepreneur/innovation centers, and public and private organizations to promote and explain the objectives of the program may be necessary.

CTEP’s mission is to improve the lives of cancer patients by finding better ways to treat, control and cure cancer. CTEP accomplishes this mission by funding an extensive national program of cancer research and by sponsoring clinical trials to evaluate new anti-cancer agents and combinations, with a particular emphasis on translational research to elucidate molecular targets and mechanisms of drug effects.

RRP manages NCI’s support for research across the radiation sciences spanning clinical trials, combined modality radiotherapy, experimental therapeutics, radiation treatment planning, radiobiology, physics, and technology. RRP establishes priorities, allocates resources, and evaluates the effectiveness of radiation research being conducted by NCI grantees.

Through its SPORE Program (Specialized Programs of Research Excellence), TRP is committed to reducing cancer incidence and mortality and improving survival and quality of life for cancer patients. TRP uses advances in basic sciences to develop new approaches for the diagnosis and treatment of cancer by fostering interdisciplinary investigations and coordinating the resources of NCI with those of academia, industry, and nonprofit organizations and foundations.

Qualifications
Applicants must meet the following minimum educational requirement: completion of a bachelor’s or graduate/higher level degree with major study in an academic field related to the medical field, health sciences or allied sciences appropriate to the work of the position. Additional specialized experience will be required and will be outlined in the vacancy announcement, when posted at a later date. Read more about the required qualifications of a Health Scientist Administrator.

These are full-time Federal Government positions located in Rockville, Maryland. Applicants must be U.S. Citizens. Compensation for these positions is commensurate with the individual's qualifications and experience, as permitted with Federal Government appointments.

How to Apply

1. Interested candidates should submit a letter of interest and CV via email to the relevant contact below:
   CTEP: Dr. Lori Henderson; hendersonlori@mail.nih.gov
   RRP: Dr. Paula Jacobs; jacobsp@mail.nih.gov
   TRP: Dr. Peter Ujhazy; ujhazyp@mail.nih.gov
2. To be considered as a candidate for these positions, you must apply to a vacancy announcement when it becomes available on WWW.USAJOBS.GOV at a later date.
   
   The NIH Global Recruitment Announcements are posted three times per year. Please see the NIH Office of Human Resources website.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

DCTD’s Cancer Imaging Program (CIP), is seeking a candidate for the position of Supervisory Physician (Associate Director).

Responsibilities

• Serves as the Associate Director (AD) within the CIP Office of the Associate Director (OAD) with overall responsibility for research, education, and coordination of activities related to oncologic imaging for the extramural NCI community
• Plans, conducts, coordinates and evaluates a broad array of national and international laboratory and clinical research programs designed to identify and develop new imaging approaches to the diagnosis and treatment of cancer
• Supervises research activities in the field of oncologic molecular imaging (i.e., the development of imaging modalities targeted to specific biochemical or physiological processes in cancer cells)
• Formulates the major overall scientific and operational policies of the program related to a comprehensive and complex program of activities supported by grants, contracts, cooperative agreements, and partnerships with universities, private industry, and other federal agencies
• Manages scope of activities related to oncologic imaging including leading technological development initiatives in imaging, such as conventional and interventional radiology, computed tomography, nuclear medicine, ultrasound, magnetic resonance, and photoelectronic imaging
• Is a highly capable and experienced leader to carry out the following duties:
  • Recruiting personnel, evaluating performance, and managing budgets for 20% of the time
  • Devoted to scientific leadership and priority setting
  • Providing leadership for pre-clinical and clinical efforts in support of NCI's Imaging Drug Group, a collection of programs to stimulate development and dissemination of new imaging agents
  • Establishing effective partnerships with academia, industry, and other Federal agencies to ensure that innovative imaging technology is developed and successfully transferred, enhanced, and commercialized by supporting grants, contracts, and other mechanisms
  • Representing NCI on many levels including national and international scientific oncology meetings (The World Molecular Imaging Society (WMIS), Society of Nuclear Medicine and Molecular Imaging (SNMMI), American Society of Clinical Oncology (ASCO), the American Association for Cancer Research, and others)

Qualifications

• An active medical license
• Experience in the conduct of clinical research for adults with cancer.
• A clinical background and training in a relevant specialty (radiology, pathology, etc)
• Knowledge of, and experience in grant and contract processes and policies, cancer research, plus administrative and managerial experience. This includes planning, analysis, evaluation, coordination, and integration of research support across program areas, divisional boundaries of responsibility within NCI, inter-institute boundaries of responsibility at NIH, and the boundaries of responsibility of other Federal and non-Federal agencies that support cancer treatment-related research (preclinical development of immunotherapies) and a constant assessment of DCTD research program priorities in relation to existing resources for funding to meet scientific objectives at the program level.

Candidates must be U.S. citizens.

Applicants must meet the minimum educational and training requirements set by the U.S. Office of Personnel Management (OPM) for the Medical Officer Series (0602). Additional specialized experience will be required and will be outlined in the vacancy announcement, when posted at a later date.

How to Apply

This is an exploratory ad to gauge interest and develop a possible candidate pool. A vacancy announcement for a Supervisory Physician, GP-602-15, will be posted on WWW.USAJOBS.GOV at a later date.

Interested candidates should send their resumes to NCIDCTDvacancyinquiry@mail.nih.gov.

This is a full-time government position in Rockville, Maryland. Compensation for this position is commensurate with the individual's qualifications as permitted within Federal Government appointments.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

DCTD’s Radiation Research Program (RRP), is seeking a candidate for the position of Supervisory Physician (Associate Director).

Responsibilities

• Serves as the primary NCI official with overall responsibility for research, education, and coordination of activities related to radiation oncology and biology for the extramural NCI community
• Plans, conducts, coordinates and evaluates national preclinical, translational, and clinical research efforts for radiation oncology and radiation biology
• Formulates the major overall scientific and operational policies of the Program related to a comprehensive and complex program of activities supported by grants, contracts, cooperative agreements, and partnerships with universities, private industry, and other federal agencies
• Manages scope of activities for radiation oncology and biology research and development including radiation physics, clinical oncology, radiation biology for a range of modalities including X-rays, particle therapy, other forms of energy (e.g., hyperthermia), radiation sensitizers and radiation protectors
• Is a highly capable and experienced leader to carry out the following duties:
  • Recruiting personnel, evaluating performance, and managing budgets for 20% of the time
  • Devoted to scientific leadership and priority setting
  • Setting a national agenda for radiation oncology research and expertise in the effects of radiation on a population
  • Interfacing with other agencies involved in radiation research and policy including the Department of Defense, Food and Drug Administration, Department of Energy, NASA, Environmental Protection Agency, Department of Homeland Security (DHS), Centers for Medicare & Medicaid Services, and the Department of Veterans Affairs
  • Representing NCI on many levels including national scientific meetings, national oncology organizations (American Society of Clinical Oncology, American Society of Therapeutic Radiology and Oncology, the American Association for Cancer Research, the Radiation Research Society, the American Cancer Society, and others), and at international venues (All-Ireland Cancer Consortium, International Atomic Energy Agency (IAEA), and others
  • Constantly assessing DCTD's research program priorities in relation to existing resources for funding to meet program objectives at the Program level

Qualifications

• An active medical license
• Experience in the conduct of clinical research for adults with cancer.
• A clinical background and training in a relevant specialty (radiation oncology, radiology, and radiation biology)
• Knowledge of, and experience in grant and contract processes and policies, cancer research, plus administrative and managerial experience.

Candidates must be U.S. citizens.

Applicants must meet the minimum educational and training requirements set by the U.S. Office of Personnel Management (OPM) for the Medical Officer Series (0602). Additional specialized experience will be required and will be outlined in the vacancy announcement, when posted at a later date.

How to Apply

This is an exploratory ad to gauge interest and develop a possible candidate pool. A vacancy announcement for a Supervisory Physician, GP-602-15, will be posted on WWW.USAJOBS.GOV at a later date.

Interested candidates should send their resumes to NCIDCTDvacancyinquiry@mail.nih.gov. You may also contact Dr. Paula Jacobs at paula.jacobs@nih.gov with questions regarding this position.

This is a full-time government position in Rockville, Maryland. Compensation for this position is commensurate with the individual's qualifications as permitted within Federal Government appointments.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

DCTD’s Cancer Therapy Evaluation Program (CTEP), Clinical Investigations Branch (CIB), is seeking a candidate for the position of Physician.

Responsibilities
The scope of activities that CTEP/CIB oversees includes:

• Coordinates the disease-oriented clinical trials research development program of the DCTD, NCI
• Develops and evaluates multi-modality anticancer therapies through the sponsorship of clinical trials
• Responsible for the majority of extramural, NCI-sponsored cancer treatment clinical trials conducted in the United States, largely through interactions with investigators within NCI-sponsored Clinical Trials Networks, as well as other clinical trial organizations and consortia
• Participates in developing the research projects preparatory to phase 3 studies, including phase 1, 2, pilot and laboratory-translational trials in conjunction with other components of CTEP
• Extensively interacts with the CTEP Investigational Drug Branch, DCTD Cancer Imaging Program, DCTD Cancer Diagnosis Program, extramural and intramural clinical investigators, NCI-sponsored Clinical Trials Networks, and other NCI Divisions
• Opportunities for continued patient care, teaching, and direct participation in clinical research are available.

Qualifications

• Experience in the conduct of clinical research for adults with cancer
• An active medical license
• A clinical background and training in a relevant oncology sub-specialty (such as medical, radiation, gynecologic, or surgical oncology, etc.)
• Experience of phase 1,2, and 3 clinical trials, cancer biology, pharmacology, and clinical trial designs.

Candidates must be U.S. citizens.

Applicants must meet the minimum educational and training requirements set by the U.S. Office of Personnel Management (OPM) for the Medical Officer Series (0602). Additional specialized experience will be required and will be outlined in the vacancy announcement, when posted at a later date.

How to Apply
This is an exploratory ad to gauge interest and develop a possible candidate pool.

Interested candidates should send their resumes to NCIDCTDvacancyinquiry@mail.nih.gov, or contact Dr. Maragret Mooney at: 240-276-6006, with questions regarding this position.

To be considered as a candidate for this position, you must apply to the vacancy announcement for a Physician (Clinical), GP-602-15, when it becomes available on WWW.USAJOBS.GOV at a later date.

The NIH Global Recruitment Announcements are posted three times per year. Please see the NIH Office of Human Resources website.

This is a full-time government position in Rockville, Maryland. Compensation for this position is commensurate with the individual’s qualifications as permitted within Federal Government appointments.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

DCTD’s Cancer Therapy Evaluation Program (CTEP), Clinical Investigations Branch (CIB), is seeking a candidate for the position of Physician.

Responsibilities

• Oversee a pediatric cancer clinical trials portfolio focusing on the incorporation of new molecular characterization and novel therapeutic strategies into clinical trials for children and adolescents with cancer
• Provide oversight for a clinical research portfolio for selected childhood cancers
• Support projects and programs directed at the optimal prioritization of novel agents and new treatment approaches for evaluation in children with cancer and for then overseeing implementation of the resulting clinical trials; the prioritization process includes internal CTEP review meetings, as well reviews conducted by the Disease Steering Committees (SC) relevant for childhood cancers (i.e., the Pediatric Leukemia Lymphoma SC, the Pediatric and Adolescent Solid Tumor SC, and the Brain Malignancy SC)
• Serve as a scientific liaison for pediatric cancer research to CTEP grantees (e.g., Children’s Oncology Group (COG) Disease Committees) and for other organizations with which CTEP interacts to accomplish its pediatric cancer research mission (e.g., pharmaceutical companies, patient advocacy organizations, and regulatory agencies)
• May coordinate and participate in NCI-supported trans-Division scientific initiatives such as the Childhood Cancer Data Initiative, the Pediatric Immunotherapy Network, the Targeting Fusion Oncoproteins in Childhood Cancers Network, and others

The scope of activities that NCI/DCTD/CTEP/CIB oversees includes:

• Sponsors and funds a broad range of clinical trials for children, adolescents, and adults with cancer through a variety of clinical trials groups and consortia
• Works collaboratively with clinical investigators in NCI-funded clinical trial networks, often in collaboration with pharmaceutical industry partners, to optimize the development of cancer treatments in the public interest, and to increase understanding of the cancers being studied
• Coordinates and oversees the NCI’s National Clinical Trials Network Program (NCTN), which includes COG, plus the Pediatric Brain Tumor Consortium (PBTC), the Pediatric Early Phase Clinical Trials Network (PEP-CTN), the Childhood Cancer Survivor Study (CCSS), and the Pediatric Preclinical in Vivo Testing (PIVOT) program
• Facilitates and supports clinical research, including surgical and radiation therapy, as well as chemo-, biologic- and immuno-therapies in the treatment of cancer

Qualifications

• An active medical license
• A clinical background with board certification in pediatric hematology/oncology
• Experience with the biology and genomics of childhood cancers, clinical trial design, and the development of novel therapies in the pediatric oncology setting

Candidates must be U.S. citizens.

Applicants must meet the minimum educational and training requirements set by the U.S. Office of Personnel Management (OPM) for the Medical Officer Series (0602). Additional specialized experience will be required and will be outlined in the vacancy announcement, when posted at a later date.

How to Apply
Interested candidates should contact Dr. Malcolm Smith (Malcolm.Smith@nih.gov) or Dr. Nita Seibel (seibelnl@nih.gov) with questions regarding this position.

To be considered as a candidate for these positions, you must apply to a vacancy announcement when it becomes available on WWW.USAJOBS.GOV at a later date.

The NIH Global Recruitment Announcements are posted three times per year. Please see the NIH Office of Human Resources website.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

DCTD’s Cancer Therapy Evaluation Program (CTEP), Investigational Drug Branch (IDB), is seeking a candidate for the position of Supervisory Physician (Branch Chief).

Responsibilities

• Is vitally important to DCTD because clinical trials are NCI’s primary interface with the public, with Congress, and with patients
• Implements and oversees a portfolio of novel cancer agents in an innovative, investigational experimental therapeutics program
• Makes daily decisions that are critical to how trials are conducted, which cancers are prioritized, which agents are selected for development in NCI’s national and international networks, and what resources (financial and personnel) are committed to them
• Is a highly capable and experienced leader to carry out the following duties:
  • Advising the Associate Director, CTEP, and Director, DCTD in all matters pertaining to NCI drug development
  • Advising leaders in the Developmental Therapeutics Program, DCTD on the appropriate preclinical experiments in animal models to guide human trials in the IDB
  • Guiding the interactions with pharmacologists, pathologists and translational scientists at the Frederick Research Labs, NCI, to develop, validate, and conduct human trials using pharmacodynamic and other types of biomarkers
  • Serving as the primary spokesperson for the IDB at weekly CTEP Protocol Review Committee and Biomarker Review Committee meetings to decide which studies will be conducted by NCI/CTEP-funded trial networks
  • Representing the IDB at meetings with pharmaceutical and biotech company representatives to review their drug pipelines and to establish collaborations
  • Representing the NCI to the external national and international community at CTEP’s bi-monthly meetings with the Food and Drug Administration, displaying a leadership role at educational sessions at national meetings, such as ASCO and AACR, and responding expertly to queries from HHS, NIH, Congress, and patient advocacy groups

The scope of activities that CTEP/IDB oversees includes:

• Sponsors and funds clinical trials of novel anti-neoplastic agents that have been approved for NCI-sponsored development (NCI-IND agents)
• Works collaboratively with clinical investigators in NCI-funded clinical trial networks and with pharmaceutical industry partners to optimize the development of these anti-cancer drugs in the public interest
• Implements and provides subsequent pharmacovigilance monitoring for this wide-reaching oncology early drug development program
• Together with CTEP colleagues, shapes the clinical research development of NCI-IND agents and shepherds clinical research proposals through the scientific and regulatory hurdles necessary for the conduct of human trials
• Supports translational and clinical research of NCI-IND agents primarily through the Experimental Therapeutics Clinical Trials Network (ETCTN), as well as other NCI-funded clinical trial networks.

Qualifications

• Experience in the conduct of clinical research for adults with cancer
• An active medical license
• A clinical background and training in a relevant oncology sub-specialty (such as medical oncology, pediatric oncology, etc)
• Experience of phase 1,2, and 3 clinical trials, cancer biology, pharmacology, clinical trial design, and the development of investigational anti-cancer drugs.

Candidates must be U.S. citizens.

Applicants must meet the minimum educational and training requirements set by the U.S. Office of Personnel Management (OPM) for the Medical Officer Series (0602). Additional specialized experience will be required and will be outlined in the vacancy announcement, when posted at a later date.

How to Apply
This is an exploratory ad to gauge interest and develop a possible candidate pool.

Interested candidates should send their resumes to NCIDCTDvacancyinquiry@mail.nih.gov, or contact Dr. Maragret Mooney at: 240-276-6006, with questions regarding this position.

To be considered as a candidate for this position, you must apply to the vacancy announcement for a Physician (Clinical), GP-602-15, when it becomes available on WWW.USAJOBS.GOV at a later date.

The NIH Global Recruitment Announcements are posted three times per year. Please see the NIH Office of Human Resources website.

This is a full-time government position in Rockville, Maryland. Compensation for this position is commensurate with the individual’s qualifications as permitted within Federal Government appointments.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

DCTD’s Developmental Therapeutics Clinic (DTC) in the Office of the Director is seeking a candidate for the position of Physician.

The goal of DTC is to develop new treatments for patients with advanced cancer through innovative early phased clinical trials. Each year patients from around the world with cancers that have relapsed after standard treatment visit DTC for consultation about participation in the innovative new treatment trials conducted at NIH. DTC participates in the Experimental Therapeutics Clinical Trials Network (ETCN) and supports the work of the DCTD.

Qualifications
Applicants must meet the minimum educational and training requirements set by the U.S. Office of Personnel Management (OPM) for the Medical Officer Series (0602). Additional specialized experience will be required and will be outlined in the vacancy announcement, when posted at a later date.

This is a full-time government position in Rockville, Maryland. Compensation for this position is commensurate with the individual’s qualifications and experience as permitted within Federal Government appointments.

How to Apply
This is an exploratory ad to gauge interest and a possible candidate pool. To be considered as a candidate for this position, you must apply to a vacancy announcement when it becomes available on WWW.USAJOBS.GOV.

The NIH Global Recruitment Announcements are posted three times per year. Please see the NIH Office of Human Resources website.

Interested candidates should contact Dr. Alice Chen Alice.Chen@nih.gov.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

DCTD’s Developmental Therapeutics Clinic (DTC) in the Office of the Director is seeking candidates for the position of Clinical Fellow/Senior Clinical Fellow in the ADTTP.

Increased numbers of novel therapeutic agents and the progressively greater complexity of early-phase clinical trials have led to a need for more physicians with special skills in drug development. The ADTTP provides medical oncologists advanced training in state-of-the-science principles and technologies of developmental therapeutics, by utilizing the unique resources available within NCI.

Responsibilities

• Participate in clinical research conducted at the NIH Clinical Center in Bethesda, MD, DTC
• Refine skills in clinical investigation, including novel strategies for trial design and methodology, protocol development, execution, monitoring, conformity with ethical standards, and formulation of attainable and pertinent laboratory correlates
• Spend 40 to 60 percent of time in clinical investigations involving inpatients and outpatients at the NIH Clinical Center, including a minimum of 1.5 days in DTC clinic activities.
• Spend up to 40 percent of time in DCTD's Cancer Therapy Evaluation Program (CTEP). The CTEP component of the training will broaden the trainee's knowledge of new drug development by providing a unique opportunity to learn the principles and concepts of agent prioritization, drug development strategies, protocol development and review, investigational new drug (IND) application requirements, and adverse event assessment and reporting.

Qualifications
Candidates must meet the following requirements:

• M.D. or an equivalent degree with a license to practice medicine in the United States
• Completion of subspecialty training in adult medical oncology at a U.S. accredited institution
• Board certification or eligibility in medical oncology

A full federal package of benefits (including retirement, leave, health and life insurance, and a 401K-equivalent savings plan, etc.) is available. This is a time-limited federal appointment not-to-exceed three years because there is no assurance of a tenure-track or permanent position with NCI or NIH upon completion of the program. Salary will be commensurate with training and experience.

How to Apply
Submit your curriculum vitae, three letters of recommendation, preferably one from the medical oncology training program director or supervisor of your last professional position, and a personal statement of research goals to:

Monika Sarna
DCTD Administrative Officer
msarna@mail.nih.gov

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

The DCTD, NCI is seeking a candidate with a strong interest in studying pharmacological mechanisms of action (MOA) to fill a Molecular Pharmacologist vacancy.

The candidate will collaborate with investigators in the Developmental Therapeutics Program (DTP) by serving as an experimental pharmacologist in the Molecular Pharmacology Branch (MPB).

Responsibilities

• Providing skills in the design and management of research
• Advising other professionals regarding preclinical support for clinical trials involving anticancer drug and biological agents and for the progression of unique compounds through the agent screening and drug development process
• Developing, designing, and implementing MOA studies for testing various therapeutics based on patient, in vivo, or in vitro model-derived observations
• Interacting with DCTD staff on general matters pertaining to MOA

Qualifications

• This is a full-time Federal Government position.
• Applicants must be U.S. citizens.
• Compensation is commensurate with the candidate's qualifications and experience.
• Candidates must meet the following minimum educational requirement: Completion of a bachelor's or graduate/higher level degree with major study in an academic field related to the medical field, health sciences or allied sciences appropriate to the work of the position.
• Significant experience with hands-on laboratory molecular pharmacology enablement is desired.
• Additional specialized experience will be required and will be outlined in the vacancy announcement when it is posted at a later time.

How to Apply
This is an exploratory ad to gauge interest and a possible candidate pool. The vacancy announcement to fill this position will be posted on www.usajobs.gov at a later date.

Interested candidates may send a letter of application, curriculum vitae, and complete contact information for three references to:

Christophe Marchand, PhD
Deputy Associate Director
Developmental Therapeutics Program, DCTD
marchanc@mail.nih.gov

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

DCTD’s Developmental Therapeutics Program (DTP), Toxicology and Pharmacology Branch, is seeking a candidate for the position of Pharmacologist.

Responsibilities

• Coordinates and evaluates safety testing of investigational cancer therapies, including biopharmaceutical agents used in multiple research studies
• Develops and evaluates research protocols for appropriateness of study design and the use of pharmaceutical information
• Develops pharmacokinetic study design initiatives
• Assists in all phases of contract solicitation, including review and award for pharmacology studies
• Evaluates and interprets pharmacological data from both nonclinical and clinical studies

Qualifications
NCI is seeking candidates with a degree in the field of pharmacology or an appropriate discipline of the biological, medical, or veterinary sciences that includes at least 30 semester hours in chemistry and physiology, and 12 semester hours in pharmacology.

Candidates must be U.S. citizens.

Compensation for this position is commensurate with the individual’s qualifications and experience as permitted within Federal Government appointments.

How to Apply
This is an exploratory ad to gauge interest and a possible candidate pool. The vacancy announcement to fill these positions will be posted on: usajobs.gov at a later date.

Prospective candidates should express their interest to:

Rosemarie Aurigemma, PhD
Associate Director, DTP, DCTD
aurigemr@mail.nih.gov

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

DCTD’s Developmental Therapeutics Program (DTP), Biological Testing Branch is seeking a Branch Chief with an interest in preclinical in vivo evaluation of candidate therapies to treat cancer.

Responsibilities include supervising the following:

• Design and implementation of protocols to assure uniform and correct in vivo laboratory testing performance
• Design and development of new and improved preclinical models for in vivo testing including the establishment and characterization of patient-derived cancer models
• Management of a large repository of human and murine tumor models as a world-wide distribution service
• Other scientific personnel of multiple disciplines and various levels in support of biomedical research to advance new cancer treatments

Qualifications

• Bachelor's, Master's, and/or Doctoral degree in the field of biological sciences or related disciplines
• Knowledge of the principles, theories, and methods of preclinical research activities as relates to new drug development

Applicants must be U.S. citizens.

Grade and salary are dependent upon experience.

How to Apply
This is an exploratory ad to gauge interest and a possible candidate pool. The vacancy announcement to fill this position will be posted on www.usajobs.gov at a later date.

Prospective candidates should express their interest and submit a curriculum vitae, full contact information, and three references to:

Rosemarie Aurigemma, PhD
Associate Director, DTP, DCTD
aurigemr@mail.nih.gov

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.

DCTD is inviting qualified applications for a postdoctoral research position in the area of cancer therapeutics. The candidate will:

• Perform basic research on nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mediated signaling mechanisms in cancer therapeutics
• Investigate the role of reactive oxygen species (ROS) in the regulation of gene expression, signal transduction, and proliferation in human tumor cell systems, genetically engineered mouse models (GEMMs), as well as clinical samples.

This research effort also focuses on the development of small molecule and antibody inhibitors targeting reactive oxygen-generating epithelial tumor cell NADPH oxidases, with a special emphasis on mouse tumor models, including standard cell line xenografts, patient-derived tumor models, and GEMMs developed to understand the role of inflammatory stress on the control of NADPH oxidases, tumor initiation, and progression.

We are seeking a highly motivated individual with demonstrated scientific productivity to join the DCTD. Experience in eukaryotic molecular pharmacology, signal transduction, and the development of GEMMs is required; expertise in cell- and in vivo-based molecular pharmacodynamics and free radical biology is also desirable.

Qualifications
The ideal candidate will have a PhD in biochemistry, molecular/tumor biology, or related disciplines and preferably prior experience in the use of both in vitro and in vivo tumor models. Communication skills and the ability to collect, analyze, compile, and communicate complex scientific data both verbally and in writing is an essential prerequisite for this position. Salary is commensurate with research experience and accomplishments.

How to Apply
Please send an application package, with your resume/CV and other supporting documentation to:

Monika Sarna, Administrative Officer
Office of the Director, DCTD
Room 3A44, Building 31
31 Center Drive
National Cancer Institute, NIH
Bethesda, MD 20892
msarna@mail.nih.gov

This position is subject to a background investigation.

The NIH and NCI are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

HHS, NIH, and NCI are Equal Opportunity Employers.