The Cancer Imaging Program Convenes the 2024 Co-Clinical Imaging Research Resource Program (CIRP) Annual Hybrid Meeting and Joint Workshop on the Co-Clinical Imaging Roadmap May 20-21, 2024

National Cancer Institute Co-Clinical Imaging Research Resource Program (CIRP)

Background on the CIRP Network

The CIRP Network is a trans-NCI initiative designed to:

Provide the cancer community with web-accessible research resources for quantitative imaging in co-clinical trials (investigations in patients and mouse or human-in-mouse models)
Encourage consensus on how quantitative imaging methods can be optimized to improve the quality of imaging results for co-clinical trials
Leverage existing NCI resources and programs to ensure best practices, effective outreach, and rapid dissemination

2024 Annual Meeting Goals

Review CIRP program progress
Demonstrate CIRP web resources
Identify challenges in four areas (animal models, co-clinical trials, quantitative imaging, and informatics)
Seek solutions for data integration, protocols harmonization, and methodology standardization

2024 Annual Meeting Attendees

This year’s meeting brought together stakeholders from academia, industry, scientific communities, federal agencies, and the following nine CIRP U24 teams and one Informatics Technology for Cancer Research (ITCR) U24 team:

Washington University in St. Louis
Duke University
MD Anderson Cancer Center
University of Pennsylvania
University of Michigan
Baylor College of Medicine/University of Texas at Austin/Stanford University
University of California at San Francisco
Stanford University
University Washington/Fred Hutchinson Cancer Research Center/Brigham and Women’s Hospital
ITCR team from Washington University in St. Louis

2024 Annual Meeting Topics

CIRP program updates
- Progress reports on projects, web resources, and briefings from the nine CIRP teams and one ITCR team. CIRP supports ten co-clinical trial projects in diverse tumor types, therapeutic interventions, and imaging modalities. The ITCR project is developing a preclinical imaging informatics platform to harmonize imaging workflows.
- Four poster briefings from non-CIRP affiliated investigators pursuing research within the scientific scope of the CIRP network
- Ten traditional posters from CIRP projects and one hands-on demonstration of a preclinical imaging informatics platform
CIRP working group sessions
- Issues in small animal PET Imaging and instrumentation, and standardization for photoacoustic imaging
- Issues in data archival and web resource management infrastructure
Closed Business management session for the CIRP Steering Committee

The Co-Clinical Imaging Roadmap Workshop

Considering the CIRP network’s upcoming 10-year milestone, the network plans to outline the roles that co-clinical imaging will play in advancing precision oncology and to publish a white paper highlighting the intersection points of co-clinical imaging in advancing precision oncology in the continuum of clinical trial design.
Lead authors of the white paper provided the rationale for co-clinical imaging trial design to advance NCI’s precision oncology clinical trials efforts (NCI-MATCH, ComboMATCH, MyeloMATCH, iMATCH). Investigator discussions focused on animal models for co-clinical imaging trials, image acquisition and data processing, and informatics needs to support integration of co-clinical imaging datasets, data mining, and advanced computing.