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Last Updated: 05/11/2022

NCI Workshop on Neutron Capture Therapy (NCT) for Cancer

Presented by DCTD’s Radiation Research Program

April 20-22, 2022
Recordings: Day 1 External Link ; Day 2 External Link ; Day 3 External Link


NCT involves nuclear capture and fission reactions that occur when an appropriate isotope, e.g., boron-10, is irradiated with low-energy (thermal) neutrons. This requires powerful (high flux) neutron sources and compounds capable of delivering neutron capture isotopes selectively to tumor cells or their microenvironment.

Research institutions with nuclear reactors can provide appropriate neutron sources for NCT; however, these sites are typically located away from medical centers where patients receive standard treatment. This limitation has negatively impacted the clinical use of NCT. Following recent technological advances, medical centers can now house relatively small (comparable to proton therapy units), accelerator-based neutron sources. This new development has strengthened interest in developing and testing new NCT delivery agents and testing them in clinical trials.

Workshop Goals (Agenda)

NCI Workshop: Neutron Capture Therapy for Cancer, April 20-22, 2022. Important updates on the new phase of NCT
  • Assess the state of NCT
  • Confer on NCT compounds under development and in the pipeline
  • Stimulate new ideas for relevant neutron capture isotopes
  • Discuss and recommend the best models/methods for translational research (preclinical and clinical)

Workshop Highlights (Recordings: Day 1 External Link ; Day 2 External Link ; Day 3 External Link )

Topic Discussion Points
Clinical Trials (day 1)
  • Overview of recent developments worldwide
  • Setting up new accelerator-based facilities
    • preclinical validation studies
    • regulatory issues
  • Recent and ongoing clinical trials for:
    • recurrent head and neck cancer
    • recurrent glioblastoma
    • skin cancers
  • Design of future NCT clinical trials
Delivery Agents (day 2)
  • Novel boron delivery agents
    • small molecules
    • nanoparticles
  • Other neutron-capture nuclides
Translational Research (day 3)
  • Dosimetry
    • new methods
    • reporting
  • Evaluation of biological effects in preclinical studies
  • Optimal in vivo models

Organizing Committee

Rolf F. Barth, MD, The Ohio State University Jacek Capala, PhD, NCI
Julie Hong, MS, NCI Narayan Hosmane, PhD, Northern Illinois University
Heikki Joensuu, MD, PhD, University of Helsinki Hospital Sunil Krishnan, MD, Mayo Clinic
Akira Matsumura, MD, PhD, DrMed, University of Tsukuba Wolfgang Sauerwein, MD, German Society for Boron Neutron Capture Therapy
Reinhard Schulte, MD, Loma Linda University Amanda Schwint, PhD, National Atomic Energy Commission, National Research Council, Buenos Aires
Graca Vicente, PhD, Louisiana State University Bhadrasain Vikram, MD, NCI
Jamey Weichert, University of Wisconsin School of Medicine and Public Health

For questions, please contact Jacek Capala or Julie Hong.