DCTD Programs
Commemorating the 50th Anniversary of the National Cancer Act:
Impact of the Developmental Therapeutics Program
Congress created the Cancer Chemotherapy National Service Center in 1955, which evolved, both structurally and functionally, into today’s Developmental Therapeutics Program (DTP). DTP’s involvement in the discovery or development of many anticancer therapeutics on the market today demonstrates its indelible impact on efforts to improve the health and well-being of people with cancer.
To commemorate the 50th anniversary of the National Cancer Act, we would like to highlight DTP’s involvement in developing the following approved cancer treatments over the last 60+ years.
| Year | Drug Name(s) | Year | Drug Name(s) |
|---|---|---|---|
| 2018 | Moxetumomab pasudotox-tdfk | 1982 | Streptozotocin (NSC 85998) |
| 2015 | Dinutuximab (Unituxin, NSC 764038) Ecteinascidin 743 (NSC 648766) |
1979 | Daunorubicin (NSC 82151) |
| 2012 | Omacetaxine (homoharringtonine, NSC 141633) | 1978 | Cisplatin (cis-platinum) (NSC 119875) |
| 2010 | Eribulin (NSC 707389) Sipuleucel-T (NSC 720270) |
1977 | Carmustine (BCNU) (NSC 409962) |
| 2009 | Romidepsin (NSC 630176) Pralatrexate (NSC 713204) |
1976 | 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosurea (CCNU) (NSC 9037) |
| 2004 | Azacitidine (NSC 102816) Cetuximab (NSC 632307) |
1975 | Dacarbazine (NSC 45388) |
| 2003 | Bortezomib (NSC 681239) | 1974 | Doxorubicin (NSC 123127) Mitomycin C (NSC 26980) |
| 2000 | Entinostat (706995) | 1973 | Bleomycin (NSC 125066) |
| 1998 | Denileukin diftitox (NSC 697979) | 1970 | Floxuridine (FUDR) (NSC 27640) Mithramycin (NSC 24559) Mitotane (o-p'-DDD) (NSC 38721) |
| 1996 | Polifeprosan 20 with carmustine implant (NSC 714372) Topotecan (NSC 609699) |
1969 | Cytarabine (ARA-C) (NSC 63878) Procarbazine (NSC 77213) |
| 1995 | All-t-retinoic acid (NSC 122758) | 1967 | Hydroxyurea (NSC 32065) |
| 1992 | 2-Chlorodeoxyadenosine (NSC 105014) Paclitaxel (NSC 125973) Teniposide (NSC 122819) |
1966 | Pipobroman (NSC 25154) Thioguanine (NSC 752) |
| 1991 | Fludarabine Phosphate (NSC 312887) Pentostatin (NSC 218321) |
1964 | Melphalan (NSC 8806) Actinomycin D (NSC 3053) |
| 1990 | Hexamethylmelamine (NSC 13875) Levamisole (NSC 177023) |
1963 | Vincristine (NSC 67574) |
| 1989 | Carboplatin (NSC 241240) | 1962 | Fluorouracil (NSC 19893) |
| 1988 | Ifosfamide (NSC 109724) | 1961 | Vinblastine (NSC 49842) |
| 1987 | Mitoxantrone (NSC 301739) | 1959 | Cyclophosphamide (NSC 26271) Thiotepa (NSC 6396) |
| 1983 | Etoposide (NSC 141540) | 1957 | Chlorambucil (NSC 3088) |
DTP facilitates the discovery and preclinical development of novel therapeutic agents by providing services, resources, and leadership to the academic and private-sector research communities worldwide. DTP manages a large research grant portfolio and provides publicly available research resources for the generation of preclinical information materials, including vialed and plated compounds, tumor cells, cell extracts, natural products extracts and compounds, and bulk and formulated drugs necessary to support Investigational New Drug (IND)-directed studies.