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Last Updated: 05/14/2021

The NCI Patient-Derived Models Repository (PDMR) Reaches Milestone

Launched in 2017, the PDMR recently surpassed development of its 500th patient-derived xenograft (PDX) model.

The PDMR is a publicly accessible, national repository for early-passage, molecularly characterized patient-derived models developed from patients with solid tumors.

Models are clinically annotated with molecular information available in an easily accessible database. The PDMR includes genetic ancestry for all public models and germline sequence for a subset of the models. We are also working to establish matched in vivo and in vitro model sets wherever possible so researchers can pursue basic and translational biologic questions across these model types.

Available Numbers of PDMR Models (May 2021)
Cryopreserved PDX material 514
Patient/PDX-derived cell cultures (PDCs) 171
Cancer-associated fibroblasts (CAFs) 243
Patient-derived organoid (PDOrg) cultures 140
Matched PDX – PDOrg – PDC model sets 111
An Image Showing Cancer Diagnoses, Types, and Numbers of Publicly Available PDMR Models as of May 2021