NCI’s Patient-Derived Models Repository Announces New Models Available to the Scientific Community

The NCI Patient-Derived Models Repository (PDMR) is a national repository of patient-derived xenografts (PDXs) developed from patients with solid tumors. These models are clinically-annotated with molecular information available in an easily accessible database for the extramural community. Since the launch of the PDMR in early 2017, 166 public models have been developed from 163 unique patients, and new models continue to be added for cancer types already existing in the repository.

Several new cancer types are now available in the PDMR collection, including some rare cancers. These new cancer models are of high value to the research community and include:

• Several gynecologic cancers (ovarian², vaginal¹, carcinosarcoma¹, and cervical¹)
• Small cell lung cancer⁴ (SCLC)
• Hurthle cell neoplasm (thyroid)¹
• Osteosarcomas³ and chondrosarcoma¹
• Squamous cell skin carcinoma²
• Merkel cell carcinoma³
• Mesothelioma²

Superscripts indicate number of models available

Some of these models are, to date, one-of-a-kind within the PDMR, but additional models are expected to be added in the upcoming year for a few of these cancer types, such as ovarian and SCLC.

The PDMR now also includes genetic ancestry for all public models, and germline sequence for a subset of the models will be added in the next few months.

Read the NCI Cancer Currents Blog, “NCI Expands Repository of Cancer Research Models: A Conversation with Drs. Doroshow and Evrard” for more details on the PDMR.

Find out how to request models, or contact the NCI PDMR with questions: NCI_PDM_Repository@mail.nih.gov