This is a bar graph showing CDK4/6 blockade with Palbociclib sensitized pNETs in Pdx1-Cre; Men 1, Pten mice to anti PD-L1 therapy. Six month old tumor bearing mice were treated for four weeks with therapy, then euthanized and tumor size quantified from H and E stained pancreata. The graph shows on the x axis the presence or absence of Palbociclib and anti PD-L1. The y axis on the graph shows pNET size in millimeter squared. There are four bars on the graph. The first bar is white and shows a pNET size of approximately 15 millimeters squared for the absence of Palbociclib and anti PDL1 (control). The second bar is gray and shows approximately 4 millimeter squared size for the presence of palbociclib alone. The third bar is red and shows a pNET size of approximately 5 millimeter squared for the presence of anti PD-L1 only. The fourth bar is blue and shows a pNET size of approximately 1 millimeter squared for Palbociclib and anti PD-L1 in combination. The p value for all four bars is less than 0.0001.