This figure has three images. The top image shows a black background filled with multicolored cells showing the spatial image analysis of a human breast tumor, with cell types represented in various colors based on single cell analyses. The left image at the bottom represents is a multicolored Uniformed Manifold Approximation and Projection (UMAP) plot illustrating four pairs of primary tumors and their corresponding metastasis. The right image is a diagram of the metabolomics pathway emphasizing vulnerabilities in Triple Negative Breast Cancer tumors.