This figure shows a slightly elongated circle starting at the top left with a double helix icon. There are two red Xs on the first and third loops of the icon. Below the icon the text reads "SIK2 inhibition results in DNA damage", accompanied by an arrow pointing southwest. The arrow directs to 2 curved lines representing the break of the double helix. Below the lines the arrow points downward toward the word "cGAS" inside a pink rectangle. Another arrow beneath the pink rectangle leads to three shapes clustered together. 1. A pink rectangle labelled "STING" in the center. 2. A light blue oval beneath the rectangle labelled "TBK". 3. Behind the pink and blue shapes is a light green circle with "NF-KB" in its center. From the right side of the green circle an arrow points to 2 joined circles. The first is a light green circle marked "NF-KB" while the second is a small yellow circle joined to the right of the green circle featuring a "P" in its center. At the top of the green circle an arrow points upward to a blue line. In the center of the blue line is an arrow that curves upward and then bends to the right with the text "IFN Beta 1" above it. To the right of this arrow two additional arrows branch out from within the elongated circle to outside. One arrow rises at a 45-degree angle towards the right, ending with the label "Enhancing anti-PD-L1". The other arrow descends at a 45-degree angle toward the right concluding with "CXCL10 CCLS". Below the "CCLS" is another downward pointing arrow leading to the phrase "Enhancing T-cell recruitment".