The figure is divided into two parts.  The first part of the figure features a light blue rectangular box at the top, containing the words "SIK2 inhibitory - GRN-300".  On the left-hand side of the box, the term SIK2 is printed. The action of SIK2 leads to a decreased expression of DNA repair genes. On the right side, there is a square box labelled "PARP enzyme activity" with a red arrow pointing downward next to the word "activity". Below these images, are 3 black arrows pointing over a light blue rectangular box that contains the words "Olaparib sensitivity" with a red arrow pointing up after the word “sensitivity”. The second box, positioned to the right of the first box has the words "Olaparib + SIK2 inhibitor" displayed vertically along the side of the box, is bracketed underneath. The top of the box has three icons that represent different types of cancers: a uterus symbolizing ovarian cancer, 5 circles of various colors representing cancer cells, and a side view section of a breast - representing breast cancer.  Below the icons, there is a bracket with arrows pointing downward on each end. In the lower half of the figure on the left side is a brown shaped cell labelled "cancer cell apoptosis". On the right side is a caricature of a white mouse with a pink xenograft tumor. Beneath the picture of the mouse and tumor are the words "tumor volume reduction prolong survival".   

Figure 2. DNA damage through SIK2 inhibition activates the cGAS/STING pathway, leading to increase T-cell recruitment and anti-PD-L1 activity.