Row	SPFunction
1	
2	
3	may bind rna.
4	
5	
6	ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached.
7	negative regulator of the heat shock response. negatively affects hsf1 dna-binding activity. may have a role in the suppression of the activation of the stress response during the aging process.
8	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
9	
10	
11	nmda receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine.
12	
13	
14	
15	component of the origin recognition complex (orc) that binds origins of replication. it has a role in both chromosomal replication and mating type transcriptional silencing. binds to the ars consensus sequence (acs) of origins of replication in an atp-dependent manner.
16	
17	
18	
19	
20	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
21	
22	
23	may be involved in transcriptional regulation.
24	neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. potent inhibitor of angiogenesis. as it does not undergo the s (stressed) to r (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
25	may act as an helicase that plays a role in rna metabolism in multiple tissues and organs within the developing embryo.
26	might be involved in growth regulation, and in myelinization in the peripheral nervous system.
27	
28	
29	recognizes the ribosomal rna gene promoter and activates transcription mediated by rna polymerase i through cooperative interactions with the species-specific factor sl1. it binds specifically to the upstream control element.
30	
31	does not act as an allosteric activator of the cholera toxin catalytic subunit. component of a regulated secretory pathway involved in ca(2+)-dependent release of acetylcholine.
32	
33	polycomb group (pcg) protein. pcg proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. pcg proteins are not required to initiate repression, but to maintain it during later stages of development. they probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. component of the prc2 complex, which methylates lys-9 and lys-27 residues of histone h3.
34	
35	
36	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
37	the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the er, via the golgi up to the trans golgi network. coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-er transport of dilysine-tagged proteins. the zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (by similarity).
38	
39	grp stimulates gastrin release as well as other gastrointestinal hormones.
40	
41	
42	
43	soluble frizzled-related proteins (sfrps) function as modulators of wnt signaling through direct interaction with wnts. they have a role in regulating cell growth and differentiation in specific cell types. sfrp1 decreases intracellular beta-catenin levels (by similarity). has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. in vascular cell cycle, delays the g1 phase and entry into the s phase (by similarity). in kidney development, inhibits tubule formation and bud growth in metanephroi (by similarity). inhibits wnt1/wnt4-mediated tcf-dependent transcription.
44	
45	
46	soluble frizzled-related proteins (sfrps) function as modulators of wnt signaling through direct interaction with wnts. they have a role in regulating cell growth and differentiation in specific cell types. sfrp1 decreases intracellular beta-catenin levels (by similarity). has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. in vascular cell cycle, delays the g1 phase and entry into the s phase (by similarity). in kidney development, inhibits tubule formation and bud growth in metanephroi (by similarity). inhibits wnt1/wnt4-mediated tcf-dependent transcription.
47	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
48	
49	
50	
51	cysteine protease cleaving the c-terminal amino acid of atg8 to reveal a c-terminal glycine. atg8 ubiquitin-like activity requires the exposure of the glycine at the c-terminus for its conjugation to phosphatidylethanolamine and its insertion to membranes, which is necessary for autophagy. inhibited by n- ethylmaleimide.
52	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
53	
54	
55	derived from proteolytic degradation of complement c3, c3a anaphylatoxin is a mediator of local inflammatory process. it induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
56	may mediate activation of casp1 via asc and promote activation of nf-kappa-b via ikk.
57	may be involved in transcriptional regulation.
58	appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. phosphorylation of dmd or utrn may modulate their affinities for associated proteins (by similarity).
59	suggested to be involved in kindling epileptogenesis and hippocampal plasticity. has a strong proteolytic activity against fibronectin (by similarity).
60	
61	stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter slc2a1/glut1, but not slc2a4/glut4, expression.
62	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
63	
64	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein.
65	may have both lysophospholipase and carbohydrate-binding activities.
66	subunit of the splicing factor sf3a required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex.
67	
68	
69	oxidizes the coa esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids.
70	
71	lacks adp-ribosylation enhancing activity (by similarity).
72	
73	probable regulatory protein involved in regulating the response to growth factors.
74	binds gram-positive and gram-negative bacteria.
75	
76	
77	
78	major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
79	plays a role in hyaluronan/hyaluronic acid (ha) synthesis.
80	sperm surface antigen involved in some step of early cleavage of the fertilized oocyte.
81	
82	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
83	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule important in cns development. is likely to signal over only few cell diameters.
84	part of a complex implicated in the control of actin polymerization in cells.
85	
86	
87	serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as tnf-alpha. appears to act upstream of the jun n-terminal pathway.
88	restores repair of base-base and single- nucleotide insertion-deletion mismatches, and increases the proficiency to process heteroduplexes with two-, three-, or four- nucleotide insertion-deletion mismatches. gtbp binds covalently to g/t mismatches.
89	associated with snrnp u1, u2, u4/u6 and u5.
90	
91	
92	
93	receptor for lutropin-choriogonadotropic hormone. the activity of this receptor is mediated by g proteins which activate adenylate cyclase.
94	
95	
96	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
97	
98	molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin (by similarity).
99	
100	molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
101	
102	may play a role in growth and differentiation of tissues involved in metabolic control. may play a regulatory role during g0/g1 transition of cell growth.
103	involved in postreplication mismatch repair. binds specifically to dna containing mismatched nucleotides thereby marking the region to be excised.
104	possibly involved in t-cell activation. binds to b7-1 (cd80) and b7-2 (cd86).
105	
106	
107	
108	
109	may play an important role in modulating bone turnover. promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. in addition, inhibits osteocalcin production.
110	major component of the extracellular matrix of cartilage.
111	
112	
113	
114	
115	seems to be involved in n-acetylation (by similarity).
116	
117	catalyzes the removal of elemental sulfur from cysteine to produce alanine. it supplies the inorganic sulfur for iron- sulfur (fe-s) clusters.
118	responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase a). it catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
119	molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
120	
121	component of the elastin-associated microfibrils.
122	
123	
124	
125	
126	
127	
128	
129	acts on phosphatidylinositol (pi) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. stt4 functions in pkc1 protein kinase pathway.
130	protein transport. probably involved in vesicular traffic (by similarity).
131	
132	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
133	glycosyltransferase involved in the elongation of o- linked ligands to activate notch signaling. possesses fucose- specific beta-1,3-n-acetylglucosaminyltransferase activity.
134	
135	
136	
137	
138	
139	
140	
141	involved in complement regulation. can associate with lipoproteins and may play a role in lipid metabolism.
142	possesses significant protein thiol-disulfide oxidase activity.
143	
144	
145	
146	
147	probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as notch receptors and app (beta-amyloid precursor protein). requires the other members of the gamma-secretase complex to have a protease activity. may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. may function in the cytoplasmic partitioning of proteins.
148	could regulate export of the bud site and axial growth sites selection protein axl2 and possibly other secretory proteins from the endoplasmic reticulum in copii-coated vesicles. seems to be required for axial budding pattern in haploid cells.
149	
150	
151	
152	
153	this enzyme metabolizes arachidonic acid predominantly via a nadph-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. one of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.
154	binds gtp, gdp and gmp.
155	inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. inhibits degradation of mdm2. can reverse mdm2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions.
156	
157	cell surface adhesion protein. mediate the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes.
158	
159	
160	involved in the maturation of asn-linked oligosaccharides. trim alpha-1,2-linked mannose residues from man(9)glcnac(2) to produce first man(8)glcnac(2) then man(6)glcnac and a small amount of man(5)glcnac.
161	may act as a low affinity receptor for acetylcholine.
162	required for the processing of the 27s pre-rrna (by similarity).
163	
164	
165	
166	
167	
168	
169	binds to the fc region of immunoglobulins epsilon. high affinity receptor. responsible for initiating the allergic response. binding of allergen to receptor-bound ige leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. the same receptor also induces the secretion of important lymphokines.
170	
171	associates with cd4 or cd8 and delivers costimulatory signals for the tcr/cd3 pathway.
172	receptor for the fc region of complexed immunoglobulins gamma. low affinity receptor.
173	
174	associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mrna splicing (by similarity).
175	
176	may play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. maybe involved in microtubule formation and/or stabilization. may play a key role during tumor development and progression.
177	e2-like enzyme which forms an intermediate with ufm1 via a thioester linkage.
178	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
179	responsible for the synthesis of complex-type n-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
180	
181	
182	catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. has little activity towards prostaglandins a1 and e1.
183	
184	
185	
186	
187	
188	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
189	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb (by similarity).
190	
191	
192	
193	
194	putative atp-dependent protease.
195	
196	may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes (by similarity).
197	
198	
199	involved in the cellular defense against the biological effects of o6-methylguanine (o6-meg) in dna. repairs alkylated guanine in dna by stoichiometrically transferring the alkyl group at the o-6 position to a cysteine residue in the enzyme. this is a suicide reaction: the enzyme is irreversibly inactivated.
200	catalyzes the phosphorylation of phosphatidylinositol-4- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol-4,5-biphosphate.
201	
202	
203	
204	
205	
206	atp-dependent rna helicase which is a subunit of the eif4f complex involved in cap recognition and is required for mrna binding to ribosome. in the current model of translation initiation, eif4a unwinds rna secondary structures in the 5@#$%& untranslated region of mrnas which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
207	
208	bifunctional enzyme with both atp sulfurylase and aps kinase activity, which mediates two steps in the sulfate activation pathway. the first step is the transfer of a sulfate group to atp to yield adenosine 5@#$%&-phosphosulfate (aps), and the second step is the transfer of a phosphate group from atp to aps yielding 3@#$%&-phosphoadenylylsulfate (paps: activated sulfate donor used by sulfotransferase). in mammals, paps is the sole source of sulfate; aps appears to be only an intermediate in the sulfate- activation pathway. may have a important role in skeletogenesis during postnatal growth (by similarity).
209	interacts with the human immunodeficiency virus tat transactivator. specifically suppresses tat-mediated transactivation. probably involved in atp hydrolysis. it is possible that proteins mss1 and tbp-1 compete with each other to regulate the interaction with the transcriptional complex with the hiv gene, thereby influencing gene expression in both directions.
210	may act as a dnase and a rnase (potential).
211	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. this is a component of the iron-sulfur (ip) fragment of the enzyme.
212	type i collagen is a member of group i collagen (fibrillar forming collagen).
213	
214	p65 is a subunit of the nuclear factor kappa-b, a second messenger, which activates the transcription of a number of genes in multiple tissues. the inhibitory effect of i-kappa-b upon nf- kappa-b in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak dna-binding site which could contribute directly to dna binding in the nf-kappa-b complex.
215	scaffold protein which probably links toll-like receptors (tlrs) to basic cellular processes via its interaction with the complex containing irak kinases and traf6. can activate ap1/jun and elk1. not required for nf-kappa-b activation. probably involved in innate immune response.
216	component of the n-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an asn-x-ser/thr consensus motif in nascent polypeptide chains. n-glycosylation occurrs cotranslational and the complex associates with the sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (er). sst3a seems to be involved in complex substrate specificity (by similarity).
217	
218	
219	augments natural killer cell activity in spleen cells and stimulates interferon gamma production in t-helper type i cells.
220	probable transcription factor. may play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues.
221	
222	appears to play a role in the switch from cap-dependent to ires-mediated translation during mitosis, apoptosis and viral infection. cleaved by some caspases and viral proteases.
223	binds to and inhibits the transcriptional repressor zbtb33, which may lead to activation of target genes of the wnt signaling pathway (by similarity). may associate with and regulate the cell adhesion properties of both c- and e-cadherins. implicated both in cell transformation by src and in ligand- induced receptor signaling through the egf, pdgf, csf-1 and erbb2 receptors.
224	
225	may be involved in signal transduction as a component of a multimeric receptor complex.
226	forms calcium-sensitive chloride channels. may conduct other physiologically significant anions such as bicarbonate.
227	may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. it is essential for disk morphogenesis.
228	
229	
230	catalyzes the conversion of pgh2 to pgd2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation.
231	receptor-proximal protein kinase regulating integrin- mediated signal transduction. may act as a mediator of inside-out integrin signaling. focal adhesion protein part of the complex ilk-pinch. this complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also akt1 and gsk3b.
232	as-c proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
233	occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
234	
235	single stranded dna-dependent atp-dependent helicase. has a role in chromosome translocation. the dna helicase ii complex binds preferentially to fork-like ends of double-stranded dna in a cell cycle-dependent manner. it works in the 3@#$%&-5@#$%& direction. binding to dna may be mediated by p70. involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination. the ku p70/p86 dimer acts as regulatory subunit of the dna-dependent protein kinase complex dna-pk by increasing the affinity of the catalytic subunit prkdc to dna by 100-fold. the ku p70/p86 dimer is probably involved in stabilizing broken dna ends and bringing them together. the assembly of the dna-pk complex to dna ends is required for the nhej ligation step. required for osteocalcin gene expression (by similarity).
236	may act as a modulator of the olfactory signal- transduction cascade.
237	may play an important role in lipogenesis.
238	may regulate the transcription of specific genes during normal development. may play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. implicated in the transduction of shh signal (by similarity).
239	catalyzes the exchange of eukaryotic initiation factor 2-bound gdp for gtp.
240	molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
241	protease that regulate the availability of igfs by cleaving igf-binding proteins.
242	acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
243	plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mglurs) at synapses (by similarity).
244	orphan receptor. could be a chemotactic peptide receptor. may have a function in bone metabolism. acts as a coreceptor for several siv strains (sivmac316, sivmac239, sivmacl7e-fr and sivsm62a), as well as a primary hiv-1 strain (92ug024-2).
245	orphan receptor. could be a chemotactic peptide receptor. may have a function in bone metabolism. acts as a coreceptor for several siv strains (sivmac316, sivmac239, sivmacl7e-fr and sivsm62a), as well as a primary hiv-1 strain (92ug024-2).
246	may play a role in the regulation of pre-mrna processing.
247	important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex gpib-ix-v. also acts as a chaperone for coagulation factor viii, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
248	
249	may be a regulatory site in cholesterol biosynthetic pathway.
250	
251	
252	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters. binds to the tax-responsive element (tre) of htlv-i. mediates pka-induced stimulation of cre-reporter genes.
253	
254	
255	
256	
257	
258	may have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
259	
260	
261	
262	collagen type iv is specific for basement membranes.
263	
264	
265	responsible for the deiodination of t4 (3,5,3@#$%&,5@#$%&- tetraiodothyronine) into rt3 (3,3@#$%&,5@#$%&-triiodothyronine) and of t3 (3,5,3@#$%&-triiodothyronine) into t2 (3,3@#$%&-diiodothyronine). rt3 and t2 are inactive metabolites. may play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. can regulate circulating fetal thyroid hormone concentrations throughout gestation. essential role for regulation of thyroid hormone inactivation during embryological development.
266	type i collagen is a member of group i collagen (fibrillar forming collagen).
267	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein.
268	
269	inhibits nf-kappa-b by complexing with and trapping it in the cytoplasm. may be involved in regulation of transcriptional responses to nf-kappa-b, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. controlled by sequential serine-phosphorylation, ubiquitination and degradation. tyrosine-phosphorylation could only lead to dissociation from nf-kappa-b.
270	this is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.
271	
272	
273	
274	
275	required for protein transport from the er to the golgi complex.
276	
277	
278	nuclear phosphoprotein which forms a tight but non- covalently linked complex with the jun/ap-1 transcription factor. in the heterodimer, c-fos and jun/ap-1 basic regions each seems to interact with symmetrical dna half sites. has a critical function in regulating the development of cells destined to form and maintain the skeleton. it is thought to have an important role in signal transduction, cell proliferation and differentiation.
279	bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. has also low glutathione peroxidase activity with t- butyl and cumene hydroperoxides. is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.
280	binds the ligand binding domain of the thyroid receptor (thrb) in the presence of triiodothyronine and enhances thrb- modulated transcription. golgi auto-antigen; probably involved in maintaining cis-golgi structure.
281	transcription factor capable of interacting with purine rich repeats (ga repeats). necessary for the expression of the adenovirus e4 gene.
282	
283	forms a channel with a broad specificity. mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, na(+), k(+), cl(-), and deprotonated monocarboxylates are excluded. also permeable to urea but not to glycerol.
284	required for protein transport from the er to the golgi complex.
285	
286	growth suppressor that facilitates the entry of the cell into cell cycle arrest. functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as sv40 large t antigen, adenovirus e1a, and the transcription factor e2f. necdin also interacts with p53 and works in an additive manner to inhibit cell growth. functions also as transcription factor and binds directly to specific guanosine-rich dna sequences (by similarity).
287	
288	
289	
290	
291	binds to, and destabilizes, ornithine decarboxylase. does not accelerate ornithine decarboxylase degeneration (by similarity).
292	
293	
294	may methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
295	putative dna helicase component of the ino80 complex which remodels chromatin by shifting nucleosomes. its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates. the ino80 complex is involved in dna repair by associating to ser-129 phosphorylated h2a histones as a response to dna damage.
296	
297	
298	
299	
300	
301	required only in the female germ line. it is important for oocyte formation and in the specification of the posterior structures of the embryo.
302	
303	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. it is a crucial enzyme in transmembrane signaling.
304	
305	
306	
307	may be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. in mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
308	catalyzes the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. is also responsible for the sulfation and activation of minoxidil. mediates the metabolic activation of carcinogenic n-hydroxyarylamines to dna binding products and could so participate as modulating factor of cancer risk.
309	
310	
311	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
312	
313	
314	
315	
316	
317	septins are gtpases involved in cytokinesis that assemble into filaments and form a ring at the cleavage site. may act by recruiting myo1 and hof1, a protein involved in septation, to the site of cleavage. septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
318	may be involved in several stages of intracellular trafficking (by similarity).
319	
320	
321	
322	it participates in a very early step in initiation. rp-a is a single-stranded dna-binding protein. absolutely required for simian virus 40 dna replication in vitro.
323	
324	seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. may be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. the calcium-bound recoverin prolongs the photoresponse.
325	
326	role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation (by similarity).
327	
328	protein transport. probably involved in vesicular traffic (by similarity).
329	
330	inhibits ipf1/pdx1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (by similarity). in complex with cul3, involved in ubiquitination of both pcgf4 and h2afy.
331	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
332	
333	
334	gtpase-activating protein for the adp ribosylation factor family (potential).
335	able to form cytoplasmic structures termed death effector filaments. enhances apaf1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. seems to bind atp.
336	adds a myristoyl group to the n-terminal glycine residue of certain cellular and viral proteins.
337	pair-rule protein that regulates embryonic segmentation and adult bristle patterning. transcriptional repressor of genes that require a bhlh protein for their transcription (e.g. the fushi tarazu gene).
338	complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. known to act on mmp-1, mmp-2, mmp-3, mmp-7, mmp-8, mmp-9, mmp-10, mmp-13, mmp-14, mmp-15, mmp-16 and mmp-19.
339	this multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. at the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. may therefore cause structural modifications of exofacial proteins. inside the cell, seems to form/rearrange disulfide bonds of nacent proteins. at high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. at low concentrations, facilitates aggregation (antichaperone activity). may be involved with other chaperones in the structural modification of the tg precursor in hormone biogenesis. also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein mttp.
340	
341	
342	may play a role in vesicular transport from endoplasmic reticulum to golgi.
343	may play a key role in signal transduction and growth control.
344	may be involved in targeting uroplakins to urothelial apical membranes (by similarity).
345	
346	
347	
348	may be involved in transcriptional regulation.
349	structure-specific dna repair endonuclease responsible for the 5-prime incision during dna repair.
350	associated to surface igm-receptor; may be involved in signal transduction.
351	receptor for the lysosphingolipid sphingosine 1- phosphate (s1p). s1p is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. is coupled to both the g(i/0)alpha and g(12) subclass of heteromeric g-proteins (by similarity). may play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
352	
353	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i (by similarity).
354	
355	v-snare that mediates vesicle transport pathways through interactions with t-snares on the target membrane. these interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. may participate in protein trafficking in the secretory pathway.
356	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
357	stimulates the dissociation of gdp from the ras-related rala and ralb gtpases which allows gtp binding and activation of the gtpases. interacts and acts as an effector molecule for r-ras, h-ras, k-ras, and rap.
358	has a tumor-suppressor role for nes1 in breast and prostate cancer.
359	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
360	creates a soluble precursor oligosaccharide fuc-alpha ((1,2)galbeta-) called the h antigen which is an essential substrate for the final step in the soluble a and b antigen synthesis pathway. h and se enzymes fucosylate the same acceptor substrates but exhibit different km values.
361	
362	catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. sulfates hydroxysteroids like dhea. isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.
363	
364	
365	cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (nk) cells to mediate tumor cell lysis.
366	
367	could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. pro-apoptotic protein that functions intracellularly upstream of jnk activation and cytochrome c release.
368	
369	transcriptional activator. binds to fat body-specific enhancers of alcohol dehydrogenase (adh) and yolk protein genes. bbf-2 may play a role in fat body gene expression. it binds the consensus sequence 5@#$%&-t[ac]nacgtan[tg]c-3@#$%&.
370	
371	
372	part of the ap-3 complex, an adaptor-related complex which is not clathrin-associated. the complex is associated with the golgi region as well as more peripheral structures. it facilitates the budding of vesicles from the golgi membrane and may be directly involved in trafficking to lysosomes.
373	
374	induces a hyperpolarization-activated chloride current when expressed in xenopus oocytes. may have a functional role in muscle contraction.
375	connects the two cox monomers into the physiological dimeric form (by similarity).
376	may be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides (by similarity).
377	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
378	
379	cochaperone that binds directly to hsc70 and hsp70 and regulates their atpase activity.
380	
381	involved in cytokinesis (potential).
382	
383	gtpase-activating protein for the adp ribosylation factor family (by similarity).
384	
385	
386	
387	receptor for members of the ephrin-a family. binds to ephrin-a1, -a4 and -a5. binds more poorly to ephrin-a2 and -a3. may play a role in a signal transduction process involved in hindbrain pattern formation.
388	protein kinase that act on both serine and threonine residues.
389	
390	
391	this is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
392	
393	serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as tnf-alpha. appears to act upstream of the jun n-terminal pathway.
394	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
395	cleaves the distal alpha 1,2-linked glucose residue from the glc(3)man(9)glcnac(2) oligosaccharide precursor in a highly specific manner.
396	
397	involved in the synthesis of the sugar donor dol-p-man which is required in the synthesis of n-linked and o-linked oligosaccharides and for that of gpi anchors. it is required for spore germination. has an essential role in cellular metabolism.
398	participates in the innate immune response to microbial agents. cooperates with tlr2 and modulates the response to microbial constituents. acts via myd88 and traf6, leading to nf- kappa-b activation, cytokine secretion and the inflammatory response (by similarity).
399	
400	
401	
402	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
403	
404	
405	fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
406	
407	essential subunit of n-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an asn-x-ser/thr consensus motif in nascent polypeptide chains.
408	plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
409	soluble frizzled-related proteins (sfrps) function as modulators of wnt signaling through direct interaction with wnts. they have a role in regulating cell growth and differentiation in specific cell types. sfrp3/frzb appears to be involved in limb skeletogenesis. antagonist of wnt8 signaling. regulates chondrocyte maturation and long bone development.
410	cell surface proteoglycan that bears heparan sulfate.
411	important for bud site selection.
412	transcriptional activator which recognizes variations of the palindromic sequence 5@#$%&-attcccnngggaatt-3@#$%& (by similarity).
413	vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.
414	the physiological function of prp is not known.
415	
416	
417	
418	
419	
420	
421	
422	
423	may facilitate pttg1 nuclear translocation.
424	
425	
426	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. has a sulfatase activity.
427	
428	
429	regulates cell cycle checkpoints and apoptosis in response to dna damage, particularly to dna double-strand breaks. inhibits cdc25c phosphatase by phosphorylation on ser-216, preventing the entry into mitosis. may also play a role in meiosis. regulates the tp53 tumor suppressor through phosphorylation at thr-18 and ser-20.
430	
431	component of the nadph-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from nadph to molecular oxygen, generating reactive oxidant intermediates. it may be important for the assembly and/or activation of the nadph-oxidase complex.
432	
433	
434	
435	
436	
437	could be involved in cell-cell interactions.
438	
439	
440	
441	
442	receptor for the c-x-c chemokine cxcl16. used as a coreceptor by sivs and by strains of hiv-2 and m-tropic hiv-1.
443	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
444	seems to have a role in retrograde membrane traffic at the level of the golgi complex.
445	receptor involved in the costimulatory signal essential for t-lymphocyte proliferation and interleukin 2 production, by binding cd28 or ctla-4. may play a critical role in the early events of t-cell activation and costimulation of naive t-cells, such as deciding between immunity and anergy that is made by t- cells within 24 hours after activation. isoform 2 interferes with the formation of cd86 clusters, and thus acts as a negative regulator of t-cell activation.
446	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. has angiogenic inhibitor activity (by similarity). active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture (by similarity).
447	probable transcriptional regulator.
448	catalyzes the exchange of eukaryotic initiation factor 2-bound gdp for gtp.
449	
450	may play a role in growth regulation and in negative regulation of cell cycle progesssion.
451	
452	can catalyze the production of ltc4 from lta4 and reduced glutathione. can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione.
453	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
454	
455	involved in neutrophil activation. in vitro, ena-78(8- 78) and ena-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.
456	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. preferentially uses palmitoleate, oleate and linoleate.
457	may be involved in the regulation of cellular proliferation and/or differentiation.
458	this is the receptor for stem cell factor (mast cell growth factor). it has a tyrosine-protein kinase activity. binding of the ligands leads to the autophosphorylation of kit and its association with substrates such as phosphatidylinositol 3-kinase (pi3k).
459	
460	
461	
462	
463	cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (by similarity).
464	
465	acts as a transcriptional repressor. may play a role in limb-pattern formation. acts in cranofacial development and specifically in odontogenesis.
466	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. this isozyme is required for growth on lactate at high temperature.
467	prevents motor-neuron apoptosis induced by a variety of signals.
468	
469	
470	binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh).
471	protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation.
472	
473	
474	
475	dual specificity phosphatase that dephosphorylates map kinase erk2 on both thr-183 and tyr-185.
476	this protein is the receptor for csf-1, it is a protein tyrosine-kinase transmembrane receptor.
477	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
478	likely to be an important mediator of ventricular differentiation during cardiac development.
479	acts as probably catalytic component of the ccr4-not core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mrna deadenylase involved in mrna turnover. in vitro, pop2 has 3@#$%&- exoribonuclease activity with a preference for poly(a) rnas, but also degrades poly(u) and poly(c) rnas. is part of a glucose- sensing system involved in growth control in response to glucose availability.
480	could be involved in the activation of both nf-kappa-b via a nf-kappa-b inhibitor kinase (ikk)-dependent mechanism and stress-activated protein kinase (sapk)/jnk.
481	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. this isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-hne).
482	probable transcription activator for a number of lung- specific genes.
483	
484	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. this subunit is involved in antigen processing to generate class i binding peptides.
485	
486	histone h3, along with histone h4, plays a central role in nucleosome formation.
487	
488	
489	putative odorant receptor.
490	
491	involved in the presentation of foreign antigens to the immune system.
492	in cooperation with other chaperones, hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. these chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. they bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
493	unknown.
494	may be involved in transcriptional regulation.
495	involved in gm1/gd1b/ga1 ganglioside biosynthesis.
496	may function as an androgen-independent transactivator of the prostate-specific antigen (psa) promoter. binds to 5@#$%&-ggat- 3@#$%& dna sequences. may play a role in the regulation of the prostate gland and/or prostate cancer development. acts as a transcriptional activator for serpinb5 promoter.
497	
498	hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
499	may act as a gtpase activating protein for rab family protein(s) (potential).
500	
501	
502	
503	anchoring protein that mediates the subcellular compartmentation of protein kinase a (pka) and protein kinase c (pkc).
504	
505	
506	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
507	
508	may play an important role in the apoptotic process, possibly within the modified cytoskeleton. its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.
509	
510	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
511	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
512	
513	
514	plays a role in limb and brain development. implicated in the transduction of shh signal (by similarity).
515	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to sites in the 5@#$%&-flanking sequence of its coding region with various affinities. the consensus sequences of the high and low affinity binding sites are 5@#$%&-taatga[cg]-3@#$%& and 5@#$%&-ctaatttt- 3@#$%&.
516	seems to have numerous potential physiological functions. binds to collagen, thrombospondin, anionic phospholipids and oxidized ldl. may function as a cell adhesion molecule. directly mediates cytoadherence of plasmodium falciparum parasitized erythrocytes. binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.
517	promotes guanine-nucleotide exchange on arf1. promotes the activation of arf through replacement of gdp with gtp.
518	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
519	probable pseudophosphatase. contains a ser residue instead of a conserved cys residue in the dsptpase catalytic loop which probably renders it catalytically inactive as a phosphatase. the binding pocket may be however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases.
520	binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes. in the absence of shh, ptc represses the constitutive signaling activity of smo. also regulates another target, the gli oncogene. intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. displays both floor plate- and motor neuron-inducing activity. the threshold concentration of n-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (by similarity).
521	since they lack a putative transactivation domain, the small mafs behave as transcriptional repressors when they dimerize among themselves. however, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific dna-binding sites. small maf proteins heterodimerize with fos and may act as competitive repressors of the nf-e2 transcription factor.
522	
523	transcription termination factor. binds to a 28 bp region within the trna(leu(uur)) gene at a position immediately adjacent to and downstream of the 16s rrna gene, this region comprises a tridecamer sequence critical for directing accurate termination. probably requires one or more components for termination activity.
524	
525	
526	
527	
528	
529	
530	lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes.
531	
532	
533	
534	catalyzes the covalent attachment of ubiquitin to other proteins. mediates the selective degradation of short-lived and abnormal proteins.
535	its role might be as part of the apparatus concerned with the nuclear events of the cell cycle.
536	
537	
538	this protein is associated with sn-rnp u2. it helps the a@#$%& protein to bind stem loop iv of u2 snrna (by similarity).
539	orphan receptor.
540	
541	tryptophan degradation.
542	
543	
544	
545	stimulatory or required for the translocation of secretory proteins across the er membrane.
546	interacts with a specific negative regulatory element (nre) 5@#$%&-aattcctctga-3@#$%& to mediate transcriptional repression of certain nk-kappa-b responsive genes. involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced inos promoter activity. also involved in the regulation of il-8 transcription.
547	catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl coa as substrates.
548	could be involved in calcium-dependent cell adhesion or intercellular interactions.
549	histone demethylase that specifically demethylates lys-9 and lys-36 residues of histone h3, thereby playing a central role in histone code. does not demethylate histone h3 lys-4, h3 lys-27 nor h4 lys-20. demethylates trimethylated h3 lys-9 and h3 lys-36 residue, while it has no activity on mono- and dimethylated residues. demethylation of lys residue generates formaldehyde and succinate.
550	
551	
552	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction. interacts with beta-1 and beta-2, but not with beta-3.
553	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction. interacts with beta-1 and beta-2, but not with beta-3.
554	conversion of dopamine to noradrenaline.
555	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
556	involved in rna polymerase iii-mediated transcription. integral, tightly associated component of the dna-binding tfiiic2 subcomplex that directly binds trna and virus-associated rna promoters.
557	
558	
559	
560	
561	inhibits hemopoiesis and stimulate chemotaxis. chemotactic in vitro for thymocytes and activated t-cells, but not for b-cells, macrophages, or neutrophils. shows preferential activity towards naive t-cells. may play a role in mediating homing of lymphocytes to secondary lymphoid organs. binds to ccr7.
562	asymmetrically hydrolyzes ap4a to yield amp and atp. plays a major role in maintaining homeostasis.
563	forms a water-specific channel that provide kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. also slightly permeable to urea and glycerol. may play an important role in gastrointestinal tract water transport and in glycerol metabolism (by similarity).
564	forms a water-specific channel that provide kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. also slightly permeable to urea and glycerol. may play an important role in gastrointestinal tract water transport and in glycerol metabolism (by similarity).
565	
566	endostatin potently inhibits angiogenesis (by similarity).
567	
568	atp dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
569	receptor for obesity factor (leptin). on ligand binding, mediates signaling through jak2/stat3. involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. may play a role in reproduction. can also mediate the erk/fos signaling pathway (by similarity).
570	
571	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
572	not known. possible housekeeping role.
573	
574	
575	
576	mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient. it is a tetrodotoxin-sensitive na(+) channel isoform. plays a role in pain mechanisms, especially in the development of inflammatory pain (by similarity).
577	involved in protein n-glycosylation. essential for the second step of the dolichol-linked oligosaccharide pathway.
578	required for constitutive membrane traffic. inhibits gtpase-stimulated na(+)/h(+) exchange. also inhibits calcineurin phosphatase activity. required for activity of slc9a1/nhe1.
579	methylates the carboxyl group of the c-terminal leucine residue of protein phosphatase 2a catalytic subunits (ppp2ca) to form alpha-leucine ester residues (by similarity).
580	human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin s but that differ in their specificity due to amino acid sequence differences. cystatin sn, with a pi of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase i than is cystatin s, although both inhibit ficin equally well.
581	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. binds poly(rg).
582	collagen type iii occurs in most soft connective tissues along with type i collagen.
583	
584	
585	
586	
587	
588	the steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. activated, but not phosphorylated, by hipk3.
589	
590	
591	
592	
593	
594	
595	
596	
597	
598	
599	type i collagen is a member of group i collagen (fibrillar forming collagen).
600	
601	degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules.
602	functions as a renin and prorenin cellular receptor. may mediate renin-dependent cellular responses by activating erk1 and erk2. by increasing the catalytic efficiency of renin in agt/angiotensinogen conversion to angiotensin i, it may also play a role in the renin-angiotensin system (ras).
603	may be involved in growth regulation of b-cells.
604	
605	
606	cbf binds to the core site, 5@#$%&-pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, lck, il-3 and gm-csf promoters. cbfb enhances dna binding by runx1.
607	accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. all three isoforms alter the functional properties of kv1.4 and kv1.5. isoform kvb1.2 has no effect on kv1.1, kv1.2 or kv2.1.
608	may be involved in actively transporting phosphate into cells via na(+) cotransport in the renal brush border membrane. probably mediates 20-30% of the apical influx.
609	
610	platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. binding of this growth factor to its affinity receptor elicits a variety of cellular responses. it is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heal the wound.
611	involved in the presentation of foreign antigens to the immune system.
612	
613	
614	
615	
616	possible role in cell-cell interactions. integrin alpha pat-1/beta pat-3 is a receptor for laminin. integrin alpha pat- 2/beta pat-3 recognizes the sequence r-g-d in its ligands (by similarity).
617	
618	severs microtubules in vitro in an atp-dependent manner. this activity may promote rapid reorganization of cellular microtubule arrays, such as during disassembly of interphase microtubules at the g2-m transition. may also be required for microtubule release from the centrosome after nucleation. in mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux. in neurons, microtubule release within the cell body may allow their subsequent transport into neuronal processes by microtubule dependent motor proteins. this transport is required for axonal growth (by similarity).
619	
620	
621	
622	this protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
623	may play a role in axon guidance (by similarity).
624	
625	
626	
627	involved, with rad23 in spindle pole body duplication. involved in the ubiquitin-proteasome proteolytic pathway.
628	stimulates specifically the gtpase activity of ypt6.
629	core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal dna. component of several complexes which regulate chromatin metabolism. these include the type b histone acetyltransferase (hat) complex, which is required for chromatin assembly following dna replication; the core histone deacetylase (hdac) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodelling and histone deacetylase complex (the nurd complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the prc2/eed-ezh2 complex, which promotes repression of homeotic genes during development.
630	probably involved in redox regulation of the cell. regulates the activation of nf-kappa-b in the cytosol by a modulation of i-kappa-b-alpha phosphorylation.
631	receptor for progesterone (by similarity).
632	
633	receptor for cxcl9, cxcl10 and cxcl11 and mediates the proliferation of human mesangial cells (hmc). isoform 2 is a receptor for cxcl4 and also mediates the inhibitory activities of cxcl9, cxcl10 and cxcl11 on the growth of human microvascular endothelial cells (hmvec). isoform 2 may play a role in angiogenesis. isoform 3 mediates activity of cxcl11.
634	
635	
636	chromosomal protein that binds to methylated dna. it can bind specifically to a single methyl-cpg pair. it is not influenced by sequences flanking the methyl-cpgs. mediates transcriptional repression through interaction with histone deacetylase and the corepressor sin3a.
637	
638	
639	component of the nua4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. the nua4 complex atpase and helicase activities seem to be, at least in part, contributed by the association of ruvbl1 and ruvbl2 with ep400. nua4 may also play a direct role in dna repair when directly recruited to sites of dna damage. also component of the msin3a complex which acts to repress transcription by deacetylation of nucleosomal histones.
640	mediates estrogen action in various target organs.
641	may play a role in the regulation of enzymatic activity in the liver. decrease of rgn leads to the dysregulation of calcium signaling in the aged liver.
642	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
643	
644	
645	
646	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes.
647	does not have alcohol dehydrogenase activity. binds nadp and acts through a one-electron transfer process. orthoquinones are the best substrates. may act in the detoxification of xenobiotics.
648	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
649	
650	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
651	involved in complement regulation. can associate with lipoproteins and may play a role in lipid metabolism.
652	
653	involved in the base excision repair (ber) pathway, by catalyzing the poly(adp-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in dna metabolism. this modification follows dna damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of dna strand breaks.
654	
655	
656	
657	required for protein transport from the er to the golgi complex.
658	affects the rate of fibrils formation. may have a primary role in collagen fibrillogenesis (by similarity).
659	receptor for the fc region of complexed or aggregated immunoglobulins gamma. low affinity receptor. involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by b- cells. binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on b-cells (bcr), t-cells (tcr) or via another fc receptor. isoform iib1 fails to mediate endocytosis or phagocytosis. isoform iib2 does not trigger phagocytosis.
660	
661	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. may play a role in leukemogenesis.
662	
663	
664	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein.
665	
666	cytosolic crabps may regulate the access of retinoic acid to the nuclear retinoic acid receptors. crabp2 may participate in a regulatory feedback mechanism to control the action of retinoic acid on cell differentiation.
667	
668	may selectively regulate the apical recycling and/or transcytotic pathways (by similarity).
669	
670	
671	
672	when complexed to birc5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized apaf1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. down-regulates hepatitis b virus (hbv) replication.
673	
674	nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. it stimulates division and differentiation of sympathetic and embryonic sensory neurons.
675	receptor for the fc region of complexed immunoglobulins gamma. low affinity receptor.
676	receptor for the fc region of complexed immunoglobulins gamma. low affinity receptor.
677	directly associates with hs1, through binding to its n- terminal region. may function in promoting cell survival. may also associate with cortactin/ems1 in nonlymphoid cells.
678	angiotensin-3 stimulates aldosterone release.
679	promotes apoptosis, pro-caspase-9 maturation and activation of nf-kappa-b via nik and ikk. may be an adapter protein between upstream tnfr1-tradd-rip complex and the downstream nik-ikk-ikap complex.
680	
681	
682	
683	can reduce the dialdehyde protein-binding form of aflatoxin b1 (afb1) to the nonbinding afb1 dialcohol. may be involved in protection of liver against the toxic and carcinogenic effects of afb1, a potent hepatocarcinogen (by similarity).
684	catalyzes specific phosphoryl transfer from atp to ump and cmp.
685	
686	
687	probable guanine nucleotide exchange factor.
688	alpha-l-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end n- acetylglucosamine of the carbohydrate moieties of glycoproteins.
689	cytokine that binds to tnfrsf18/aitr/gitr. important for interactions between activated t-lymphocytes and endothelial cells and may modulate t-lymphocyte survival in peripheral tissues.
690	
691	
692	
693	
694	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
695	
696	
697	
698	required for the proper development and maintenance of neurons presumably by affecting rna metabolism.
699	
700	type i collagen is a member of group i collagen (fibrillar forming collagen).
701	
702	
703	
704	involved in the splicing process and participates in early heat shock-induced splicing arrest. due to their great structural variations the different isoforms may possess different functions in the splicing reaction.
705	
706	
707	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
708	
709	converts phytanoyl-coa to 2-hydroxyphytanoyl-coa.
710	regulates eif4e activity by preventing its assembly into the eif4f complex. mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the map kinase pathway.
711	
712	may be involved in transcriptional regulation.
713	necessary for the splicing of pre-mrna. it is required for formation of the earliest atp-dependent splicing complex and interacts with spliceosomal components bound to both the 5@#$%& and 3@#$%& splice sites during spliceosome assembly. it also is required for atp-dependent interactions of both u1 and u2 snrnps with pre-mrna (by similarity). can bind to the myelin basic protein (mbp) gene mb3 regulatory region and increase transcription of the mbp promoter in cells derived from the cns.
714	
715	cleaves arg-arg-beta-naphthylamide.
716	may play a role in fat metabolism.
717	required for checkpoint mediated cell cycle arrest in response to dna damage or the presence of unreplicated dna. may also negatively regulate cell cycle progression during unperturbed cell cycles. recognizes the substrate consensus sequence [r-x-x- s/t]. binds to and phosphorylates cdc25a, cdc25b and cdc25c. phosphorylation of cdc25a at ser-178 and thr-507 and phosphorylation of cdc25c at ser-216 creates binding sites for 14- 3-3 proteins which inhibit cdc25a and cdc25c. phosphorylation of cdc25a at ser-76, ser-124, ser-178, ser-279 and ser-293 promotes proteolysis of cdc25a. inhibition of cdc25 activity leads to increased inhibitory tyrosine phosphorylation of cdk-cyclin complexes and blocks cell cycle progression. binds to and phosphorylates rad51 at thr-309, which may enhance the association of rad51 with chromatin and promote dna repair by homologous recombination. binds to and phosphorylates tlk1 at ser-743, which prevents the tlk1-dependent phosphorylation of the chromatin assembly factor asf1a. this may affect chromatin assembly during s phase or dna repair. may also phosphorylate multiple sites within the c-terminus of tp53, which promotes activation of tp53 by acetylation and enhances suppression of cellular proliferation.
718	
719	
720	
721	has heparin binding activity, and growth promoting activity. involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. also involved in early fetal adrenal gland development (by similarity).
722	amp deaminase plays a critical role in energy metabolism.
723	this protein may be involved in the regulation of b-cell activation and proliferation.
724	component of heterochromatin. recognizes and binds histone h3 tails methylated at lys-9, leading to epigenetic repression. can interact with lamin b receptor (lbr). this interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. involved in the formation of functional kinetochore through interaction with mis12 complex proteins.
725	tumor suppressor that may be involved in interferon- dependent cell death.
726	may be involved in protein-protein interaction.
727	
728	
729	switches off fancd2-mediated dna repair by promoting fancd2 deubiquitination.
730	
731	
732	
733	may function in pre-mrna splicing.
734	may play a role in a erbb3-regulated signal transduction pathway. seems be involved in growth regulation. acts a corepressor of the androgen receptor (ar) and is regulated by the erbb3 ligand neuregulin-1/heregulin (hrg). inhibits transcription of some e2f1-regulated promoters, probably by recruiting histone acetylase (hat) activity. binds rna. associates with 28s, 18s and 5.8s mature rrnas, several rrna precursors and probably u3 small nucleolar rna. may be involved in regulation of intermediate and late steps of rrna processing. may be involved in ribosome assembly (by similarity). mediates cap-independent translation of specific viral iress (internal ribosomal entry site). together with ptbp1 is required for the translation initiation on the foot- and-mouth disease virus (fmdv) ires.
735	
736	
737	receptor for prostaglandin f2-alpha (pgf2-alpha). the activity of this receptor is mediated by g proteins which activate a phosphatidylinositol-calcium second messenger system. initiates luteolysis in the corpus luteum (by similarity).
738	causes the formation of thin, actin-rich surface projections called filopodia. functions cooperatively with cdc42 and rac to generate additional structures, increasing the diversity of actin-based morphology.
739	
740	
741	selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
742	
743	
744	
745	is able to inhibit all four classes of proteinases by a unique @#$%&trapping@#$%& mechanism. this protein has a peptide stretch, called the @#$%&bait region@#$%& which contains specific cleavage sites for different proteinases. when a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. the entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
746	involved in lymphocyte activation. binds to hla class-ii antigens.
747	binds preferentially single-stranded dna and unwinds double stranded dna.
748	
749	
750	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. mct2 is a high affinity pyruvate transporter.
751	associated with snrnp u1, u2, u4/u6 and u5.
752	
753	forms a water-specific channel. implicated in the generation of saliva, tears, and pulmonary secretions.
754	protein tyrosine phosphatase which stimulates progression from g1 into s phase during mitosis. promotes tumors. inhibits geranylgeranyl transferase type ii activity by blocking the association between rabggta and rabggtb.
755	promotes the exchange of gsp1/gsp2-bound gdp by gtp. involved in yeast pheromone response pathway and in mrna metabolism. probably involved in the control of nuclear organization.
756	poly[adp-ribose] polymerase modifies various nuclear proteins by poly(adp-ribosyl)ation. the modification is dependent on dna and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from dna damage.
757	
758	
759	single-stranded structure-specific dna endonuclease involved in dna excision repair. makes the 3@#$%&incision in dna nucleotide excision repair (ner). acts as a cofactor for a dna glycosylase that removes oxidized pyrimidines from dna. may also be involved in transcription-coupled repair of this kind of damage, in transcription by rna polymerase ii, and perhaps in other processes too.
760	
761	cleaves proteins, imported into the mitochondrion, to their mature size.
762	transcription regulator that acts as a key regulator of lineage commitment of immature t-cell precursors. necessary and sufficient for commitment of cd4 lineage, while its absence causes cd8 commitment. development of immature t-cell precursors (thymocytes) to either the cd4 helper or cd8 killer t-cell lineages correlates precisely with their t-cell receptor specificity for major histocompatibility complex class ii or class i molecules, respectively. transcriptional repressor of the collagen col1a1 and col1a2 genes. may also function as a repressor of fibronectin and possibly other extracellular matrix genes (by similarity).
763	initiates the extrinsic pathway of blood coagulation. serine protease that circulates in the blood in a zymogen form. factor vii is converted to factor viia by factor xa, factor xiia, factor ixa, or thrombin by minor proteolysis. in the presence of tissue factor and calcium ions, factor viia then converts factor x to factor xa by limited proteolysis. factor viia will also convert factor ix to factor ixa in the presence of tissue factor and calcium.
764	cleaves the alpha-chain at multiple sites and the beta- chain between lys-53 and lys-54 but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. it does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. activates coagulation factor vii.
765	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins. plays an essential role during mouse embryonic development.
766	
767	
768	
769	
770	
771	
772	promotes the exchange of ras-bound gdp by gtp (by similarity).
773	fk506- and rapamycin-binding proteins (fkbps) constitute a family of receptors for the two immunosuppressants which inhibit t-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. ppiases accelerate the folding of proteins.
774	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters. represses transcription from promoters with atf sites. it may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (by similarity).
775	cochaperone that stimulates hsp90 atpase activity (by similarity). may affect a step in the endoplasmic reticulum to golgi trafficking.
776	this enzyme is necessary for target cell lysis in cell- mediated immune responses. it cleaves after asp. seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
777	
778	interacts with key regulators (cbp, p300 and pcaf) of transcription and represses transcription. acts as a histone- binding protein that regulates transcription. acts as a deubiquitinating enzyme.
779	processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. involved in melanosome transport. may also be required for some polarization process involved in dendrite formation.
780	
781	
782	
783	
784	
785	involved in nucleolar processing of pre-18s ribosomal rna (by similarity).
786	
787	
788	may transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of n-linked oligosaccharides of glycoproteins and may be involved in psa (polysialic acid) expression.
789	may be involved in protection of cells from uv-induced cell death.
790	
791	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity). overexpression may be associated with abnormal proliferation in human breast tissue.
792	cytosolic crabps may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
793	
794	
795	the glycine cleavage system catalyzes the degradation of glycine. the h protein shuttles the methylamine group of glycine from the p protein to the t protein.
796	
797	
798	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of calcium (by similarity).
799	glycosyltransferase required for the biosynthesis of heparan-sulfate. the ext1/ext2 complex possesses substantially higher glycosyltransferase activity than ext1 or ext2 alone. appears to be a tumor suppressor.
800	
801	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. the core protein 2 is required for the assembly of the complex.
802	
803	
804	
805	may play an important role in fibrillogenesis by controlling lateral growth of collagen ii fibrils.
806	
807	type i collagen is a member of group i collagen (fibrillar forming collagen).
808	
809	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
810	may be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.
811	transfers a sulfuryl group to an n-unsubstituted glucosamine linked to a 2-o-sulfo iduronic acid unit on heparan sulfate. catalyzes the o-sulfation of glucosamine in glca2s-glcns. unlike 3-ost-1, does not convert nonanticoagulant heparan sulfate to anticoagulant heparan sulfate.
812	required for intramitochondrial proteolysis. catalyzes the initial steps of protein degradation.
813	this protein seems to be functional equivalent to rat prostatic spermine-binding protein, which is involved in polyamine binding.
814	
815	transcriptional activator that binds to the at-rich core sequence of the enhancer element of the afp gene.
816	
817	thiolesterase that catalyzes the hydrolysis of s-d- lactoyl-glutathione to form glutathione and d-lactic acid.
818	
819	probable trna acetyltransferase required for the formation of the modified nucleoside n(4)-acetylcytidine in serine and leucine trnas. binds rna.
820	
821	
822	
823	
824	
825	probable adapter protein involved in signaling pathways. interacts with the sh2 and sh3 domains of various signaling proteins when it is phosphorylated. may promotes fyn activation, possibly by disrupting intramolecular sh3-dependent interactions (by similarity).
826	
827	clathrin is the major protein of the polyhedral coat of coated pits and vesicles. two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-golgi network.
828	
829	
830	
831	
832	positive effector of the eif-2-alpha kinase activity of gcn2.
833	
834	recognizes and binds the 7-methylguanosine-containing mrna cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mrnas secondary structures.
835	recognizes and binds the 7-methylguanosine-containing mrna cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mrnas secondary structures.
836	
837	
838	transcriptional regulator involved in development.
839	
840	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
841	mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. the receptor recognizes terminal galactose and n-acetylgalactosamine units. after ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. the receptor then returns to the cell membrane surface.
842	creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
843	
844	functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (nls) in cargo substrates, or by acting as autonomous nuclear transport receptor. acting autonomously, serves itself as nls receptor. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran-dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. mediates autonomously the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in association with ipo7 mediates the nuclear import of h1 histone. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones.
845	may play a role in neoplasia. may counteract a default induction of apoptosis in g2/m phase. interacts with tubulin. inhibitor of caspase-3 and caspase-7.
846	control of topological states of dna by transient breakage and subsequent rejoining of dna strands. topoisomerase ii makes double-strand breaks.
847	
848	
849	
850	
851	may play a role in the proliferation or differentiation of keratinocytes.
852	
853	
854	
855	
856	ena/vasp proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodelling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. vasp promotes actin nucleation and increases the rate of actin polymerization in the presence of capping protein. plays a role in actin-based activity of listeria monocytogenes in platelets (by similarity).
857	retains nfe2l2/nrf2 in the cytosol thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression (by similarity).
858	
859	binds to the caccc box in the beta-globin gene promoter and activates transcription (by similarity).
860	cytokine that binds to tnfrsf7/cd27. plays a role in t- cell activation. induces the proliferation of costimulated t-cells and enhances the generation of cytolytic t-cells.
861	
862	transcriptional activator which binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. its transcriptional activity is enhanced by ccnd3 and slightly inhibited by cdk4.
863	putative transcription factor that binds to the sph and gt-iic @#$%!enhansons@#$%! (5@#$%&-gtggaatgt-3@#$%&). may be involved in the gene regulation of neural development. binds to the m-cat motif (by similarity).
864	may act as effector for golgi-bound hras and other ras- like proteins. may promote hras-mediated transformation.
865	probably involved in cell proliferation and cell-cell interactions.
866	promotes guanine-nucleotide exchange on arf1, arf3 and arf6. promotes the activation of arf through replacement of gdp with gtp.
867	
868	negatively modulates rna polymerase ii function by binding to rpb5.
869	
870	cytokine that drives rapid clonal expansion of naive but not memory cd4(+) t-cells. it also strongly synergizes with il-12 to trigger ifn-gamma production of naive cd4(+) t-cells. mediates its biologic effects through the cytokine receptor wsx-1/tccr.
871	may antagonize nodal signaling and subsequent organization of axial structures during mesodermal patterning (by similarity).
872	
873	required for correct progression through g2 phase of the cell cycle and entry into mitosis. required for rcor1/corest mediated repression of neuronal specific gene promoters.
874	factor d cleaves factor b when the latter is complexed with factor c3b, activating the c3bbb complex, which then becomes the c3 convertase of the alternate pathway. its function is homologous to that of c1s in the classical pathway.
875	
876	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. involved in the interferon/all-trans-retinoic acid (ifn/ra) induced cell death. this apoptotic activity is inhibited by interaction with viral irf1. prevents the transactivation of stat3 target genes. may play a role in card15- mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
877	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. l is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes.
878	
879	binds vldl and transports it into cells by endocytosis. in order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. binding to reelin induces tyrosine phosphorylation of dab1 and modulation of tau phosphorylation (by similarity).
880	
881	
882	
883	prevents motor-neuron apoptosis induced by a variety of signals.
884	
885	receptor for members of the ephrin-a family. binds to ephrin-a1, -a4 and -a5. binds more poorly to ephrin-a2 and -a3. may play a role in a signal transduction process involved in hindbrain pattern formation.
886	
887	
888	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
889	involved in redox regulation of the cell. reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. may play an important role in eliminating peroxides generated during metabolism. might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of h(2)o(2).
890	stimulates transcription from the hsp70 promoter.
891	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
892	
893	
894	factor that represses transcription. it binds to the gc- rich sequences (5@#$%&-gcggggc-3@#$%&) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters.
895	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
896	collagen type iv is specific for basement membranes.
897	
898	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis (by similarity).
899	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
900	
901	
902	acts preferentially on the c-jun n-terminal kinase (jnk) and p38 mapks. plays an important role in the heavy metal stress response by negatively regulating the kgb-1 (jnk-like) and the pmk-1 (p38-type) mapk signaling pathways.
903	
904	
905	microtubule-based anterograde translocator for membranous organelles (by similarity).
906	involved in transport of proteins into the mitochondrion.
907	
908	
909	
910	
911	may play a role in spermatogenesis.
912	sequence-specific dna-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. ap-2 factors bind to the consensus sequence 5@#$%&-gccnnnggc-3@#$%& and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. they also suppress a number of genes including mcam/muc18, c/ebp alpha and myc.
913	
914	protease involved in mll processing and, consequently, in the correct expression of the early hoxa gene cluster.
915	acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane (by similarity).
916	may be involved in the pdh (pyruvate dehydrogenase complex) bypass.
917	
918	responsible for the modification of a37 to isopentenyl a37 of both cytosolic and mitochondrial trnas.
919	
920	
921	may play a role in the processes of lymphocyte homing to secondary lymphoid organs.
922	
923	has deoxyribonuclease activity. it is endonucleolytic with single-strand and exonucleolytic with double-strand dna. may play an important role in cell development as well as dna repair and recombination.
924	this protein mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
925	involved in the transport of the cationic amino acids (arginine, lysine and ornithine).
926	
927	may bind glycan structure with high affinity, but not heparin. has no chitotriosidase activity.
928	
929	transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (upr). acts during endoplasmic reticulum stress (er) by activating unfolded protein response (upr) target genes via direct binding to the upr element (upre). binds dna preferably to the cre-like element 5@#$%&- gatgacgtg[tg]n(3)[at]t-3@#$%&, and also to some tpa response elements (tre). binds to the hla dr-alpha promoter. binds to the tax- responsive element (tre) of htlv-i.
930	
931	catalyzes the sulfation of membrane glycolipids. seems to prefer beta-glycosides at the nonreducing termini of sugar chains attached to a lipid moiety. catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (by similarity). also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro).
932	heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. biliverdin is subsequently converted to bilirubin by biliverdin reductase. under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
933	this protein binds beta-galactoside. its physiological function is not yet known.
934	
935	
936	
937	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters. it binds to a tax-responsive enhancer element in the long terminal repeat of htlv-i.
938	single stranded dna-dependent atp-dependent helicase. has a role in chromosome translocation. the dna helicase ii complex binds preferentially to fork-like ends of double-stranded dna in a cell cycle-dependent manner. it works in the 3@#$%&-5@#$%& direction. binding to dna may be mediated by p70. involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination. the ku p70/p86 dimer acts as regulatory subunit of the dna-dependent protein kinase complex dna-pk by increasing the affinity of the catalytic subunit prkdc to dna by 100-fold. the ku p70/p86 dimer is probably involved in stabilizing broken dna ends and bringing them together. the assembly of the dna-pk complex to dna ends is required for the nhej ligation step. required for osteocalcin gene expression (by similarity).
939	single stranded dna-dependent atp-dependent helicase. has a role in chromosome translocation. the dna helicase ii complex binds preferentially to fork-like ends of double-stranded dna in a cell cycle-dependent manner. it works in the 3@#$%&-5@#$%& direction. binding to dna may be mediated by p70. involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination. the ku p70/p86 dimer acts as regulatory subunit of the dna-dependent protein kinase complex dna-pk by increasing the affinity of the catalytic subunit prkdc to dna by 100-fold. the ku p70/p86 dimer is probably involved in stabilizing broken dna ends and bringing them together. the assembly of the dna-pk complex to dna ends is required for the nhej ligation step. required for osteocalcin gene expression (by similarity).
940	
941	not known; could have a tyrosine ligase activity.
942	the 83 kda subunit binds and stabilizes the catalytic subunit at 37 degrees celsius and keeps it in circulation. under some circumstances it may be an allosteric modifier of the catalytic subunit.
943	
944	plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility. binds to c1q (by similarity).
945	required for sufficient glycogen accumulation. the alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule and, consequently, in reducing the osmotic pressure within cells.
946	control of topological states of dna by transient breakage and subsequent rejoining of dna strands. topoisomerase ii makes double-strand breaks.
947	
948	receptor for udp-glucose and other udp-sugar coupled to g-proteins. not activated by atp, adp, utp or atp.
949	
950	exports cytoplasmic heme. may be required to protect developing erythroid cells from heme toxicity. causes susceptibility to felv-c in vitro.
951	
952	atp-dependent rna helicase which is a subunit of the eif4f complex involved in cap recognition and is required for mrna binding to ribosome. in the current model of translation initiation, eif4a unwinds rna secondary structures in the 5@#$%& untranslated region of mrnas which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
953	cytokine that binds to tnfrsf10a/trailr1, tnfrsf10b/trailr2, tnfrsf10c/trailr3, tnfrsf10d/trailr4 and possibly also to tnfrsf11b/opg. induces apoptosis. its activity may be modulated by binding to the decoy receptors tnfrsf10c/trailr3, tnfrsf10d/trailr4 and tnfrsf11b/opg that cannot induce apoptosis.
954	actin-binding protein involved in motile and morphological processes. inhibits actin polymerization, likely by sequestering g-actin. prevents actin filament assembly by forming a 1:1 complex with actin monomers, and inhibits the nucleotide exchange reaction of actin monomers (by similarity).
955	seems to act exclusively upon threonine residues (by similarity).
956	
957	
958	binds preferentially single-stranded dna and unwinds double stranded dna.
959	
960	this protein binds 5s rna.
961	
962	costimulates t-cell proliferation. may regulate myeloid cell activity in a variety of tissues.
963	
964	
965	required maternally for proper expression of other homeotic genes involved in pattern formation, such as ubx.
966	
967	
968	involved in the functional recruitment of the sin3- histone deacetylase complex (hdac) to a specific subset of n-cor corepressor complexes. capable of transcription repression by n- cor. active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.
969	plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations (by similarity).
970	rate limiting enzyme for synthesis of hsact. performs the crucial step modification in the biosynthesis of anticoagulant heparan sulfate (hsact) that is to complete the structure of the antithrombin pentasaccharide binding site.
971	functions as a sorting receptor in the golgi compartment and as a clearance receptor on the cell surface. required for protein transport from the golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (m6pr). also required for protein transport from the golgi apparatus to the endosomes. promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of bdnf (probdnf) and ngfb (prongfb). also acts as a receptor for neurotensin. may promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular lpl. probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter slc2a4/glut4 (glut4 storage vesicles, or gsvs). these vesicles provide a stable pool of slc2a4 and confer increased responsiveness to insulin. may also mediate transport from the endoplasmic reticulum to the golgi.
972	binds and presumably selects ubiquitin-conjugates for destruction. displays selectivity for longer polyubiquitin chains. modulates intestinal fluid secretion.
973	chemotactic for b-lymphocytes but not for t-lymphocytes, monocytes and neutrophils. does not induce calcium release in b- lymphocytes. binds to blr1/cxcr5.
974	
975	inhibitor of phospholipase a2, also possesses anti- coagulant properties. also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
976	
977	
978	may have a role in processing of pre-rrna or in the assembly of rrna into ribosomal subunits.
979	
980	
981	
982	
983	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
984	
985	inhibitor of the caspase-activated dnase (dff40).
986	might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. may supply selenium to tissues such as brain and testis.
987	
988	
989	
990	type i collagen is a member of group i collagen (fibrillar forming collagen).
991	probable dna-repair protein.
992	
993	microtubule-based anterograde translocator for membranous organelles. plus end-directed microtubule sliding activity in vitro.
994	pp2a can modulate the activity of phosphorylase b kinase casein kinase 2, mitogen-stimulated s6 kinase, and map-2 kinase. can dephosphorylate sv40 large t antigen and p53. dephosphorylates sv40 large t antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. the c subunit was most active, followed by the ac form, which was more active than the abc form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. dephosphorylation by the ac form, but not c or abc form is inhibited by small t antigen.
995	may constitute a glutathionine peroxidase-like protective system against oxidative stresses (by similarity).
996	
997	
998	
999	acts as an adapter protein of the fyn and sh2-domain- containing leukocyte protein-76 (slp76) signaling cascades in t cells. modulates the expression of interleukin-2 (il-2).
1000	
1001	essential for the control of the cell cycle at the g2/m (mitosis) transition.
1002	
1003	responsible for the posttranslational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. in addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.
1004	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. this is a component of the iron-sulfur (ip) fragment of the enzyme.
1005	
1006	possible dna-binding subunit of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.
1007	
1008	
1009	stimulates guanylyl cyclase 1 (gc1) when free calcium ions concentration is low and inhibits gc1 when free calcium ions concentration is elevated. this ca(2+)-sensitive regulation of gc is a key event in recovery of the dark state of rod photoreceptors following light exposure.
1010	may function in the secretion of milk-fat droplets. may act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (by similarity).
1011	
1012	
1013	
1014	essential component of the nelf complex, a complex that negatively regulates the elongation of transcription by rna polymerase ii. the nelf complex, which acts via an association with the dsif complex and causes transcriptional pausing, is counteracted by the p-tefb kinase complex.
1015	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
1016	
1017	
1018	
1019	
1020	
1021	
1022	
1023	probable hydrolase. involved in the thymus homing of bone marrow cells. may regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.
1024	
1025	molecular chaperone; assists the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
1026	
1027	involved in regulation of vitamin k-dependent carboxylation of multiple amino-terminal glutamate residues. seems to inhibit gamma-carboxylase ggcx. binds 7 calcium ions with a low affinity (by similarity).
1028	in vitro; can phosphorylate histones h3 and h2b on ser and thr residues. may be involved in the regulation of cellular growth and/or development.
1029	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
1030	plays a functional role in insulin and igf-i signaling. may serve to positively link the insulin and igf-i receptors to an uncharacterized mitogenic signaling pathway. interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. the interaction is mediated by the sh2 domain. also binds activated platelet-derived growth factor receptor and epidermal growth factor receptor.
1031	
1032	
1033	
1034	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i (by similarity).
1035	inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. inhibins appear to oppose the functions of activins.
1036	
1037	may have an important role in regulating the access of circulating igfs to the tissues.
1038	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems. the g(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli.
1039	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
1040	
1041	
1042	required for the export of mrnas containing poly(a) tails from the nucleus into the cytoplasm. in case of infection by hiv-1, it may participate in the docking of viral vpr at the nuclear envelope.
1043	integrin alpha-v/beta-8 is a receptor for fibronectin.
1044	may act as a scaffolding protein within caveolar membranes. interacts directly with g-protein alpha subunits and can functionally regulate their activity. caveolin-2 may function as an accessory protein in conjunction with caveolin-1.
1045	
1046	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
1047	energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. human mdr3 is not capable of conferring drug resistance. mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.
1048	
1049	
1050	enhances pdgfa-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of pdgfb (by similarity).
1051	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
1052	
1053	
1054	
1055	catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the e1 component of the pyruvate dehydrogenase complex (by similarity).
1056	
1057	methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (can methylate hnrnpa1 and histones). methylates supt5h (by similarity).
1058	the 26s protease is involved in the atp-dependent degradation of ubiquitinated proteins. the regulatory (or atpase) complex confers atp dependency and substrate specificity to the 26s complex. interacts with the orphan nuclear hormone receptor mb67.
1059	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. may govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
1060	
1061	
1062	type i collagen is a member of group i collagen (fibrillar forming collagen).
1063	
1064	plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. this phosphodiesterase is highly specific for camp and may have a role in muscle signal transduction.
1065	catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a thr-glu-tyr sequence located in map kinases. activates erk1 and erk2 map kinases.
1066	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
1067	
1068	
1069	plays a role in photoreceptor morphogenesis in the retina. may maintain cell polarization and adhesion.
1070	phosphorylates ins(1,3,4,5,6)p5 at position 2 to form ins(1,2,3,4,5,6)p6 (insp6 or phytate). insp6 is involved in many processes such as mrna export, nonhomologous end-joining, endocytosis, ion channel regulation. it also protects cells from tnf-alpha-induced apoptosis.
1071	the glycine cleavage system catalyzes the degradation of glycine. the p protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; co(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the h protein.
1072	tyrosine kinase of the non-receptor type, involved in interleukin 3 signal transduction.
1073	tyrosine-protein kinase receptor whose role is not yet clear.
1074	
1075	likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
1076	
1077	
1078	
1079	catalyzes fat and vitamin absorption. acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.
1080	may play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. may play an important role in trafficking of t-cells in thymus, and t-cell and b-cell migration to secondary lymphoid organs. specifically binds to chemokine receptor ccr7. recombinant scya19 shows potent chemotactic activity for t-cells and b-cells but not for granulocytes and monocytes.
1081	
1082	component of the exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna (by similarity).
1083	
1084	required for t-cell activation through the antigen receptor. the first ptpase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
1085	catalyzes the conversion of dtmp to dtdp.
1086	
1087	
1088	
1089	transcription factor that binds to sequence with multiple copies of ttc[cg]g present in its own promoter and that of the hnrpa2b1 gene. down-regulates transcription of these genes. binds to the retinoic acid response element (rare) agggttcaccgaaagttca. activates the proenkephalin gene independently of promoter binding, probably through protein- protein interaction. when secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the g0 or g1 phase.
1090	
1091	active on elastin and collagen substrates (by similarity).
1092	binds calcium. may be involved in terminal differentiation of keratinocytes.
1093	seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.
1094	
1095	
1096	facilitates nuclear export of spliced mrna by releasing the rna from the spliceosome.
1097	
1098	may be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.
1099	involved in cell cycle checkpoint enforcement. can interact and phosphorylate bub3.
1100	seems to act exclusively upon threonine residues (by similarity).
1101	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase c. it could help neuronal cells to establish short- term memory.
1102	receptor for complement c3dd, for the epstein-barr virus on human b-cells and t-cells and for hnrpu. participates in b lymphocytes activation.
1103	
1104	participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.
1105	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
1106	promotes the exchange of ras-bound gdp by gtp. this protein positively controls the level of cellular camp at start, the stage at which the yeast cell division cycle is triggered.
1107	
1108	
1109	may have a regulatory role in phosphatidylcholine synthesis.
1110	
1111	involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors.
1112	
1113	may mediate uptake of degraded synaptic material which could play an important role in synaptic remodeling. can mediate the neuronal and glial uptake of the snake venom toxin taipoxin (by similarity).
1114	aminopeptidase with broad substrate specificity to several peptides. involved in proteolytic events essential for cell growth and viability. may act as regulator of neuropeptide activity (by similarity).
1115	
1116	
1117	
1118	plasma membrane-associated small gtpase which cycles between an active gtp-bound and inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.
1119	
1120	
1121	
1122	involved in the presentation of foreign antigens to the immune system.
1123	
1124	regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
1125	
1126	thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. it is capable of binding to actin, calmodulin, troponin c and tropomyosin. the interaction of calponin with actin inhibits the actomyosin mg-atpase activity (by similarity).
1127	binds to the lim domain of a wide variety of lim domain- containing transcription factors.
1128	regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. regulates tp53 by enhancing the dna binding and transactivation function of tp53 on the promoters of proapoptotic genes in vivo. inhibits the ability of appbp1 to conjugate nedd8 to cul1, and thereby decreases appbp1 ability to induce apoptosis. impedes cell cycle progression at g2/m.
1129	functions in nuclear protein import as an adapter protein for nuclear receptor kpnb1. binds specifically and directly to substrates containing either a simple or bipartite nls motif. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus.
1130	chemotactic for interleukin-activated t-cells but not unstimulated t-cells, neutrophils or monocytes. induces calcium release in activated t-cells. binds to cxcr3. may play an important role in cns diseases which involve t-cell recruitment. may play a role in skin immune responses.
1131	
1132	exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities.
1133	collagen type iii occurs in most soft connective tissues along with type i collagen.
1134	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex.
1135	c1r b chain is a serine protease that combines with c1q and c1s to form c1, the first component of the classical pathway of the complement system.
1136	required for t-cell activation through the antigen receptor. the first ptpase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
1137	appears to function in the signal transduction from ras activation to actin cytoskeletal remodelling. suppresses insulin- induced promoter activities through ap1 and sre. mediates rap1- induced adhesion.
1138	
1139	
1140	may function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling.
1141	
1142	may play an important role in lipogenesis.
1143	may be an angiogenesis inhibitor.
1144	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. active on long chain acyl-coas.
1145	
1146	atp-dependent rna helicase. acts as a cofactor for xpo1- mediated nuclear export of incompletely spliced hiv-1 rev rnas. also involved in hiv-1 replication. interacts specifically with hepatitis c virus core protein resulting in a change in intracellular location.
1147	required for the accumulation of coenzyme a in the mitochondrial matrix.
1148	acidic protein which may be involved in interactions with other proteins or dna.
1149	
1150	
1151	involved in control of the cell cycle. upon lytic infection of permissive cells, the hsv transactivator protein vp16 associates with hcfc1. binding to hcfc1 activates vp16 for association with the octamer motif-binding protein pou2f1, to form a multiprotein-dna complex responsible for activating transcription of the hsv immediate early genes. also antagonizes transactivation by zbtb17 and gabp2; represses zbtb17 activation of the p15(ink4b) promoter and inhibits its ability to recruit p300. coactivator for egr2 and gabp2. tethers the chromatin modifying set1/ash2 histone h3-k4 methyltrasferase (hmt) and sin3 histone deacetylase (hdac) complexes (involved in the activation and repression of transcription, respectively) together.
1152	
1153	not known. binds to rna homopolymers, with a preference for poly(g) and poly(u) and little for poly(a) (by similarity).
1154	in addition to its role as a glycolytic enzyme, it seems that pgk-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
1155	
1156	
1157	c1q associates with the proenzymes c1r and c1s to yield c1, the first component of the serum complement system. the collagen-like regions of c1q interact with the ca(2+)-dependent c1r(2)c1s(2) proenzyme complex, and efficient activation of c1 takes place on interaction of the globular heads of c1q with the fc regions of igg or igm antibody present in immune complexes.
1158	appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. phosphorylation of dmd or utrn may modulate their affinities for associated proteins. functions in a multi-protein complex in spermatid maturation. regulates lipopolysaccharide-induced il-12 synthesis in macrophages by forming a complex with traf6, resulting in the inhibition of traf6 nf-kappab activation (by similarity).
1159	
1160	mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. may play a role in regulating steroidogenesis.
1161	weakly inward rectifying potassium channel.
1162	
1163	
1164	essential transmembrane gtpase, which mediates mitochondrial fusion. fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. mfn2 acts independently of the cytoskeleton. it therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. overexpression induces the formation of mitochondrial networks. plays an important role in the regulation of vascular smooth muscle cell proliferation.
1165	
1166	
1167	probable component of the protein complex eif4f, which is involved in the recognition of the mrna cap, atp-dependent unwinding of 5@#$%&-terminal secondary structure and recruitment of mrna to the ribosome. thought to be a functional homolog of eif4g1.
1168	degrades chitin and chitotriose. may participate in the defense against nematodes and other pathogens. isoform 3 has no enzymatic activity.
1169	
1170	receptor for the fc region of igg. binds complexed or aggregated igg and also monomeric igg. mediates antibody-dependent cellular cytotoxicity (adcc) and other antibody-dependent responses, such as phagocytosis.
1171	
1172	probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
1173	could act as a modulator of glutaredoxin biological activity.
1174	histone methyltransferase. methylates lys-9 of histone h3. h3 lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting hp1 proteins to methylated histones. targeted to histone by trim28/tif1b and contributes to silencing of euchromatic genes by krab zinc-finger proteins.
1175	required for the first step of diphtamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from s-adenosyl-l- methionine to a histidine residue. diphthamide is a post- translational modification of histidine which occurs in elongation factor 2.
1176	
1177	
1178	trap proteins are part of a complex whose function is to bind calcium to the er membrane and thereby regulate the retention of er resident proteins.
1179	
1180	
1181	may play a role in the regulation of the immune system. seems to play a role as an inhibitor of apoptosis.
1182	
1183	
1184	hydrolyzes dna under acidic conditions with a preference for double-stranded dna. plays a major role in the degradation of nuclear dna in cellular apoptosis during development. necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear dna expelled from erythroid precursor cells.
1185	
1186	thought to be a regulatory component of the atp- synthesizing complex in the mitochondria.
1187	component of pre-mrna cleavage complex ii and of the trna splicing endonuclease complex.
1188	
1189	initiates blood coagulation by forming a complex with circulating factor vii or viia. the [tf:viia] complex activates factors ix or x by specific limited protolysis. tf plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
1190	saposin d is a specific sphingomyelin phosphodiesterase activator (ec 3.1.4.12).
1191	cytokine that binds to tnfrsf4. co-stimulates t-cell proliferation and cytokine production.
1192	
1193	receptor for tnfsf14/light and homotrimeric tnfsf1/lymphotoxin-alpha. involved in lymphocyte activation. plays an important role in hsv pathogenesis because it enhanced the entry of several wild-type hsv strains of both serotypes into cho cells, and mediated hsv entry into activated human t-cells.
1194	
1195	essential component of the tim23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
1196	
1197	straight-chain enoyl-coa thioesters from c4 up to at least c16 are processed, although with decreasing catalytic rate.
1198	
1199	
1200	
1201	participates in the second step of pre-mrna splicing.
1202	
1203	necessary for spliceosome assembly. overexpression causes apoptosis.
1204	
1205	receptor for interleukin-2.
1206	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. component of the flavoprotein-sulfur (fp) fragment of the enzyme.
1207	the function of subunit 4 is not yet known.
1208	involved in repair of uv radiation-induced dna damage. catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same dna strand upon exposure to ultraviolet radiation.
1209	involved in the conversion of lanosterol to cholesterol.
1210	
1211	mediates the endocytosis of glycoproteins by macrophages. binds both sulfated and non-sulfated polysaccharide chains. acts as phagocytic receptor for bacteria, fungi and other pathogens.
1212	
1213	
1214	delivers copper to copper zinc superoxide dismutase (sod1).
1215	
1216	catalyzes the formation of l-carnitine from gamma- butyrobetaine.
1217	
1218	
1219	
1220	involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin.
1221	catalyzes the n-methylation of nicotinamide and other pyridines to form pyridinium ions. this activity is important for biotransformation of many drugs and xenobiotic compounds.
1222	probable protease. seems to be capable of activating enac (by similarity).
1223	may play a role in vesicular transport from endoplasmic reticulum to golgi.
1224	displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols.
1225	the paf1 complex is a multifunctional complex. involved in transcription initiation via genetic interactions with tata- binding proteins. involved in elongation. it regulates 3@#$%&end formation of snr47 by modulating the recruitment or stable association of nrd1 and nab3 with rna polymerase ii. also has a role in transcription-coupled histone modification. required for activation of rad6 ubiquitin conjugate and the bre1 ubiquitin ligase which ubiquitylate lys-126 histone h2b. activates the set1 histone methyltransferase complex for methylation of lys-4 of histone h3 and for methylation of lys-73 of histone h3 by dot1 and lys-36 of histone h3 by set2. in complex with paf1, required for normal cln1 and cln2 g1 cyclin expression in late g1. also has a role in chromosome segregation where it appears to be involved in microtubule placement.
1226	may bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. may be under transcriptional regulation of steroid hormones.
1227	may be required for neuronal cell differentiation.
1228	
1229	troponin t is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin atpase activity.
1230	positively regulates the wnt signaling pathway by stabilizing beta-catenin through the association with gsk-3.
1231	
1232	component of the bactericidal ra-reactive factor rarf which specifically binds to ra and r2 polysaccharides expressed by certain enterobacteria. it triggers the activation of complement cascade by activating the c4 and c2 components. it activates the c4 component by cleaving the alpha-chain of c4.
1233	
1234	am and pamp are potent hypotensive and vasodilatator agents. numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. in the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. in pituitary gland, both peptides at physiologically relevant doses inhibit basal acth secretion. both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
1235	
1236	cleaves c-terminal amino acids linked to proline in peptides such as angiotensin ii, iii and des-arg9-bradykinin. this cleavage occurs at acidic ph, but enzymatic activity is retained with some substrates at neutral ph.
1237	the interaction with sm proteins inhibits their assembly on u rna and interferes with snrnp biogenesis. inhibits the binding of survival motor neuron protein (smn) to sm proteins. may participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.
1238	
1239	putative odorant receptor.
1240	
1241	
1242	integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. during myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. it is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. isoform alpha-7x2b and isoform alpha-7x1b promote myoblast migration on laminin 1 and laminin 2/4, but isoform alpha-7x1b is less active on laminin 1 (in vitro).
1243	enhances ar-mediated transactivation. transactivation decreases as the poly-gln length within ar increases.
1244	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
1245	
1246	
1247	
1248	
1249	
1250	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. socs2 appears to be a negative regulator in the growth hormone/igf1 signaling pathway.
1251	orphan nuclear receptor.
1252	
1253	
1254	
1255	this protein is essential for differentiation. it may play a role in localizing of nanos (a maternal determinant) activity in oocytes. bicd mutations cause nanos mislocalization and thus bicaudal development.
1256	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of calcium out of the cell.
1257	parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.
1258	
1259	component of unactivated mammalian steroid receptor complexes that sediment at 8-10 s. may have a rotamase activity. may play a role in the intracellular trafficking of hetero- oligomeric forms of steroid hormone receptors.
1260	
1261	
1262	has e3 ubiquitin protein ligase activity. regulates the levels of casp8 and casp10 by targeting them for proteasomal degradation. protects cells against apoptosis induced by tnf. binds phosphatidylinositol-5-phosphate and phosphatidylinositol-3- phosphate.
1263	
1264	probable protein kinase whose role is not yet known. may play a role in the phosphorylation of proteins central to parkinson disease. may also have gtpase activity.
1265	
1266	
1267	
1268	
1269	
1270	
1271	does not possess sterol isomerase activity and does not bind sigma ligands (by similarity).
1272	
1273	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
1274	
1275	
1276	
1277	may function in chaperone-mediated protein folding.
1278	may function as an antagonist of fibroblast growth factor (fgf) pathways and may negatively modulate respiratory organogenesis.
1279	cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. dynein has atpase activity; the force-producing power stroke is thought to occur on release of adp.
1280	may play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. extrahepatic arginase functions to regulate l-arginine bioavailability to no synthase. since no synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase ii plays a role in both male and female sexual arousal. it is therefore a potential target for the treatment of male and female sexual arousal disorders.
1281	may have a role in the cell cycle.
1282	involved in the biogenesis of the 60s ribosomal subunit (by similarity).
1283	
1284	
1285	receptor for extracellular adenine nucleotides such as atp and adp. in pancreatic islets, may mediate some of the effects of extracellular atp on insulin secretion.
1286	
1287	specifically phosphorylates the activated forms of g protein-coupled receptors.
1288	
1289	galactose-specific lectin which binds ige. may mediate with the alpha-3, beta-1 integrin the stimulation by cspg4 of endothelial cells migration.
1290	
1291	dna repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. may be involved in interstrand dna cross-link repair and in the maintenance of normal chromosome stability.
1292	functions as a negative regulator of ap-1 mediated transcription by binding to jun proteins. jun/b-atf heterodimers bind dna preferentially at the 12-o-tetradecanoylphorbol-13- acetate response element (tre) (consensus: 5@#$%&-tga[cg]tca-3@#$%&) and weaker at the camp responsive region (cre) (consensus: 5@#$%&- gtgacgt[ac][ag]-3@#$%&), but are transcriptionally inert.
1293	binds with high affinity to rna molecules that contain au-rich elements (ares) found within the 3@#$%& untranslated regions of many protooncogenes and cytokine mrnas. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain (by similarity).
1294	this enzyme is probably necessary for target cell lysis in cell-mediated immune responses.
1295	
1296	interacts with key regulators (cbp, p300 and pcaf) of transcription and represses transcription. acts as a histone- binding protein that regulates transcription. acts as a deubiquitinating enzyme.
1297	
1298	regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. confers calcium sensitivity.
1299	beta-hexosaminidase a is responsible for the degradation of gm2 gangliosides, and a variety of other molecules containing terminal n-acetyl hexosamines, in the brain and other tissues. the form b is active against certain oligosaccharides. the form s has no measurable activity.
1300	
1301	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
1302	
1303	
1304	could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. regulates the ph of melanosome and the melanosome maturation. one of the components of the mammalian pigmentary system. seems to regulate the postranslational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. may serve as a key control point at which ethnic skin color variation is determined. major determinant of brown and/or blue eye color.
1305	
1306	
1307	sequence-selective dna-binding protein. could play an important role in gene regulation.
1308	
1309	
1310	
1311	
1312	co-chaperone of hsc70. seems to play a role in protein import into mitochondria.
1313	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
1314	
1315	
1316	
1317	
1318	
1319	
1320	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. this cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. it associates with alpha-catenin forming a link to the cytoskeleton.
1321	
1322	
1323	soluble il4r (sil4r) inhibits il4-mediated cell proliferation and il5 up-regulation by t-cells.
1324	
1325	atp-dependent rna helicase involved in mrna export from the nucleus (by similarity).
1326	component of the cleavage factor im (cfim) complex that plays a key role in pre-mrna 3@#$%& processing. involved in association with cpsf6 in pre-mrna 3@#$%&-end poly(a) site cleavage and poly(a) addition. nudt21/cpsf5 binds to cleavage and polyadenylation rna substrates.
1327	may be involved in transcriptional regulation.
1328	
1329	functions in segment determination through interaction with genes of bithorax (bx-c) and antennapedia (ant-c) complexes. it can behave as an activator of bx-c. involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. shown to bind zinc (in vitro).
1330	the gpib-v-ix complex functions as the von willebrand factor receptor and mediates von willebrand factor-dependent platelet adhesion to blood vessels. the adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis (by similarity).
1331	
1332	
1333	
1334	
1335	transcriptional activator that binds to the sterol regulatory element 1 (sre-1) (5@#$%&-atcaccccac-3@#$%&). has dual sequence specificity, binding to both an e-box motif (5@#$%&-atcacgtga-3@#$%&) and to sre-1 (5@#$%&-atcaccccac-3@#$%&). regulates the transcription of genes for sterol biosynthesis and the ldl receptor gene.
1336	
1337	
1338	reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. involved in intracellular redox signaling.
1339	catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length.
1340	
1341	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
1342	
1343	
1344	this protein shows activity both toward tyrosine-protein phosphate as well as with serine-protein phosphate.
1345	
1346	
1347	prohibitin inhibits dna synthesis. it has a role in regulating proliferation. as yet it is unclear if the protein or the mrna exhibits this effect. may play a role in regulating mitochondrial respiration activity and in aging.
1348	
1349	
1350	
1351	
1352	appears to have a function in striated muscle development and regeneration.
1353	
1354	
1355	
1356	
1357	essential role in pre-mrna splicing.
1358	functions as an e3-type small ubiquitin-like modifier (sumo) ligase, stabilizing the interaction between ube2i and the substrate, and as a sumo-tethering factor. plays a crucial role as a transcriptional coregulator in various cellular pathways, including the stat pathway, the p53 pathway and the steroid hormone signaling pathway. the effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the pias2 isoform studied. however, it seems to be mostly involved in gene silencing. binds to sumoylated elk1 and enhances its transcriptional activity by preventing recruitment of hdac2 by elk1, thus reversing sumo-mediated repression of elk1 transactivation activity. isoform pias2-beta, but not isoform pias2-alpha, promotes mdm2 sumoylation. isoform pias2-beta promotes ncoa2 sumoylation more efficiently than isoform pias2-alpha.
1359	thyroid hormone-binding protein. probably transports thyroxine from the bloodstream to the brain.
1360	
1361	
1362	tumor-associated antigen.
1363	
1364	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
1365	may be involved in transcriptional regulation.
1366	co-chaperone that binds to numerous kinases and promotes their interaction with the hsp90 complex, resulting in stabilization and promotion of their activity.
1367	
1368	
1369	
1370	transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions (by similarity).
1371	formation of pseudouridine at position 38 and 39 in the anticodon stem and loop of transfer rnas (by similarity).
1372	this transcriptional activator recognizes and binds to the sequence 5@#$%&-rttaygtaay-3@#$%& found in the promoter of genes such as albumin, cyp2a4 and cyp2a5. it is not essential for circadian rhythm generation, but modulates important clock output genes. may be a direct target for regulation by the circadian pacemaker component clock. may affect circadian period and sleep regulation.
1373	probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. can be blocked by extracellular barium and cesium.
1374	
1375	cleaves peptide substrates after methionine, leucine, and norleucine.
1376	
1377	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
1378	may antagonize nodal signaling and subsequent organization of axial structures during mesodermal patterning (by similarity).
1379	
1380	
1381	can degrade fibronectin, gelatins of type i, iii, iv, and v; weakly collagens iii, iv, and v. activates procollagenase.
1382	
1383	
1384	transcription factor required for gene expression specific to photoreceptor cells.
1385	
1386	type i collagen is a member of group i collagen (fibrillar forming collagen).
1387	involved in translocation of long-chain fatty acids (lfca) across the plasma membrane. the lfca import appears to be hormone-regulated in a tissue-specific manner. in adipocytes, but not myocytes, insulin induces a rapid translocation of fatp1 from intracellular compartments to the plasma membrane, paralleled by increased lfca uptake. may act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. plays a pivotal role in regulating available lfca substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. may be involved in regulation of cholesterol metabolism. has acyl-coa ligase activity for long-chain and very-long-chain fatty acids.
1388	
1389	
1390	may act as a transcription factor for cell pluripotency and differentiation in the embryo.
1391	
1392	crystallins are the dominant structural components of the vertebrate eye lens.
1393	
1394	essential for recycling gmp and indirectly, cgmp.
1395	catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. has also a vitamin d3- 25-hydroxylase activity.
1396	this is the largest subunit of complex i and it is a component of the iron-sulfur (ip) fragment of the enzyme. it may form part of the active site crevice where nadh is oxidized.
1397	this is the largest subunit of complex i and it is a component of the iron-sulfur (ip) fragment of the enzyme. it may form part of the active site crevice where nadh is oxidized.
1398	
1399	
1400	appears to play a role in cell sterol metabolism. it may function to protect cells from over-accumulation of cholesterol.
1401	
1402	acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (by similarity). causes reduced proliferation of b-lymphocytes.
1403	
1404	catalyzes the posttranslational addition of a tyrosine to the c-terminal end of detyrosinated alpha-tubulin.
1405	
1406	
1407	
1408	
1409	
1410	putative rna helicase involved in the second step of rna splicing. may promote one or more conformational changes in the dynamic network of rna-rna interactions in the spliceosome. appears to catalyze an atp-dependent unwinding of u4/u6 rna duplices.
1411	
1412	involved in gpi-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of gpi (by similarity).
1413	involved in transport factor (ran-gtp, karyopherin)- mediated protein import via the f-g repeat-containing domain which acts as a docking site for substrates. could also have isomerase or chaperone activity and may bind rna or dna. component of the nuclear export pathway. specific docking site for the nuclear export factor exportin-1.
1414	orphan receptor.
1415	
1416	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
1417	may be involved in retrograde transport from early and late endosomes to late golgi (by similarity).
1418	attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to na-k atpase, to the lymphocyte membrane protein gp85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. in skeletal muscle, isoform mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
1419	
1420	
1421	
1422	shown to enhance tdt activity, in vitro.
1423	troponin is the central regulatory protein of striated muscle contraction. tn consists of three components: tn-i which is the inhibitor of actomyosin atpase, tn-t which contains the binding site for tropomyosin and tn-c. the binding of calcium to tn-c abolishes the inhibitory action of tn on actin filaments.
1424	glycosyltransferase required for the biosynthesis of heparan-sulfate. the ext1/ext2 complex possesses substantially higher glycosyltransferase activity than ext1 or ext2 alone. appears to be a tumor suppressor.
1425	
1426	seems to be involved in embryonic mesoderm formation. binds to 3 e-boxes of the e-cadherin gene promoter and represses its transcription.
1427	
1428	
1429	may play a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. there are four molecules of fkbp12 per skeletal muscle ryr. ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
1430	
1431	may be involved in several stages of intracellular trafficking.
1432	may play a role in chondrocyte differentiation and may also influence cervix development.
1433	transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. potential role in g2/m cell cycle regulation (by similarity).
1434	
1435	
1436	can efficiently cleave only isg15 fusions including native isg15 conjugates linked via isopeptide bonds. necessary to maintain a critical cellular balance of isg15-conjugated proteins in both healthy and stressed organisms.
1437	
1438	
1439	
1440	may regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-er compartment.
1441	catalyzes the o-sulfation of tyrosine residues within acidic motifs of polypeptides.
1442	
1443	recognizes and binds the 7-methylguanosine-containing mrna cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mrnas secondary structures.
1444	
1445	transfer of a sulfur ion to cyanide or to other thiol compounds. also has weak rhodanese activity. may have a role in cyanide degradation or in thiosulfate biosynthesis.
1446	plays a role in protein sorting and trafficking between the trans-golgi network (tgn) and endosomes. mediates the arf- dependent recruitment of clathrin to the tgn and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (ac-ll) motif.
1447	
1448	
1449	
1450	
1451	acts as a copper chaperone, transporting copper to the cu(a) site on the cytochrome c oxidase subunit ii (cox2).
1452	has a dehydrogenase activity on palmitoyl-coa (c16:0) and stearoyl-coa (c18:0). it is three times more active on palmitoyl-coa then on stearoyl-coa. has little activity on octanoyl-coa (c8:0), butyryl-coa (c4:0) or isovaleryl-coa (5:0).
1453	
1454	
1455	regulatory subunit of the pi3k complex. may regulate membrane trafficking late in the endocytic pathway.
1456	may act as a specific coactivator for the mammalian tefs (by similarity).
1457	involved in the ubiquitination and subsequent proteasomal degradation via the von hippel-lindau ubiquitination complex. seems to act as target recruitment subunit in the e3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (hif) under normoxic conditions. involved in transcriptional repression through interaction with hif1a, hif1an and histone deacetylases.
1458	receptor for oxytocin. the activity of this receptor is mediated by g proteins which activate a phosphatidylinositol- calcium second messenger system.
1459	arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
1460	
1461	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. this protein may mediate formation of the complex between cytochromes c and c1.
1462	inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (by similarity).
1463	
1464	
1465	rna-binding protein. binds poly(g) and poly(u) but not poly(a) or poly(c). regulates somite formation, probably by regulating gene expression (by similarity).
1466	
1467	
1468	
1469	
1470	
1471	
1472	
1473	microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (by similarity).
1474	isoform 1 transcriptionally activates the lyn and blk promoters and acts synergistically with runx1 to transactivate the blk promoter. isoform 2 may function in repression of runx1- mediated transactivation.
1475	ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. this enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the c-terminal glycine of ubiquitin. also binds to free monoubiquitin and may prevent its degradation in lysosomes. the homodimer may have atp-independent ubiquitin ligase activity.
1476	
1477	guanine nucleotide exchange factor (gef) for rap1a, rap1b and rap2b gtpases. does not interact with camp or cgmp.
1478	
1479	required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. stimulates dmc1-dependent homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
1480	replaces conventional h2a in a subset of nucleosomes. may be involved in the formation of constitutive heterochromatin. may be required for chromosome segregation during cell division.
1481	
1482	hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin a.
1483	
1484	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
1485	not known. may bind to chromatin.
1486	this enzyme condenses acetyl-coa with acetoacetyl-coa to form hmg-coa, which is the substrate for hmg-coa reductase.
1487	
1488	protein transport. probably involved with ras-related protein rab-3a in synaptic vesicle traffic and/or synaptic vesicle fusion. could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
1489	may be involved in transcriptional regulation. plays a role during development and organogenesis as well as in the function of the adult central nervous system (by similarity).
1490	
1491	appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. phosphorylation of dmd or utrn may modulate their affinities for associated proteins. functions in a multi-protein complex in spermatid maturation. regulates lipopolysaccharide-induced il-12 synthesis in macrophages by forming a complex with traf6, resulting in the inhibition of traf6 nf-kappab activation (by similarity).
1492	
1493	
1494	
1495	
1496	
1497	probably plays a role in anchoring the complex to other cellular components.
1498	this enzyme is necessary for target cell lysis in cell- mediated immune responses. it cleaves after lys or arg. may be involved in apoptosis.
1499	
1500	protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
1501	docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. dok3 is a negative regulator of jnk signaling in b-cells through interaction with inpp5d/ship. may modulate abl function (by similarity).
1502	this protein is a component of ribonucleosomes.
1503	directs the termination of nascent peptide synthesis (translation) in response to the termination codons uaa, uag and uga.
1504	cyclin-dependent kinases (cdks) are activated by the binding to a cyclin and mediate the progression through the cell cycle. each different complex controls a specific transition between two subsequent phases in the cell cycle. cdk7 is the catalytic subunit of the cdk-activating kinase (cak) complex, a serine-threonine kinase. cak activates the cyclin-associated kinases cdc2/cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation. cak complexed to the core-tfiih basal transcription factor activates rna polymerase ii by serine phosphorylation of the repetitive c-terminus domain (ctd) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts. involved in cell cycle control and in rna transcription by rna polymerase ii. its expression and activity are constant throughout the cell cycle.
1505	downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small gtpases to the actin cytoskeleton.
1506	electrically silent transporter system. mediates sodium and chloride reabsorption. plays a vital role in the regulation of ionic balance and cell volume.
1507	component of the anaphase promoting complex/cyclosome (apc/c), a cell cycle-regulated e3 ubiquitin-protein ligase complex that controls progression through mitosis and the g1 phase of the cell cycle. the apc/c is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating e2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26s proteasome. in early mitosis, the apc/c is activated by cdc20 and targets securin pds1, the b-type cyclin clb5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. in late mitosis and in g1, degradation of clb5 allows activation of the apc/c by cdh1, which is needed to destroy cdc20 and the b-type cyclin clb2 to allow exit from mitosis and creating the low cdk state necessary for cytokinesis and for reforming prereplicative complexes in g1 prior to another round of replication.
1508	calcium-binding protein. may have a role in calcium homeostasis.
1509	
1510	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
1511	
1512	mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). it is sensitive (es) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (nbmpr) and is sodium-independent. it has a higher affinity for adenosine. inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
1513	may be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides (by similarity).
1514	
1515	cleaves peptide bonds on the c-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
1516	
1517	
1518	
1519	not known. the authors believe that it may be involved in transmembrane signal transduction through a postulated calcium- binding function, but the evidence for the existence of a calcium- binding region is weak.
1520	could be a global transcriptional regulator. modifies gene expression by affecting chromatin (potential).
1521	component c2 which is part of the classical pathway of the complement system is cleaved by activated factor c1 into two fragments: c2b and c2a. c2a, a serine protease, then combines with complement factor 4b to generate the c3 or c5 convertase.
1522	
1523	
1524	
1525	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (by similarity).
1526	
1527	
1528	
1529	
1530	component of a protein kinase signal transduction cascade. phosphorylates and activates map2k4 and map2k6, which in turn activate the jnk and p38 map kinases, respectively. overexpression induces apoptotic cell death.
1531	b-fabp could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during cns development. it is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (by similarity).
1532	may be involved in bmp2-induced transcription (by similarity).
1533	destroys radicals which are normally produced within the cells and which are toxic to biological systems.
1534	
1535	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
1536	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
1537	may play an important role in the regulation of lymphoma cell growth. interacts with a 16-kda leu-13 protein to form a complex possibly involved in signal transduction. may acts a the viral receptor for hcv.
1538	component of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends.
1539	
1540	
1541	may be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.
1542	transcriptional activator that binds to dna sequences containing the consensus pentanucleotide 5@#$%&-cgga[at]-3@#$%&.
1543	
1544	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
1545	could be a melanogenic enzyme (by similarity).
1546	
1547	
1548	cleaves presequences (transit peptides) from mitochondrial protein precursors (by similarity).
1549	
1550	this is a receptor for calcitonin. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase. the calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
1551	
1552	
1553	
1554	accessory protein for the calcitonin gene-related peptide (cgrp) receptor. it modulates cgrp responsiveness in a variety of tissues.
1555	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity).
1556	
1557	
1558	
1559	
1560	
1561	endoribonuclease responsible for the inhibition of the translation by cleaving mrna. inhibits cell-free protein synthesis. cleaves phosphodiester bonds only in single-stranded rna (by similarity).
1562	mediates the sorting and transport of syntaxin-cargo vesicles along microtubules in neuronal processes. tne syntabulin- syntaxin interaction is required for syntaxin-cargo vesicles transport.
1563	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
1564	may function as a transcriptional activator protein and may play a key role in the organogenesis of the fat body. binds a sequence element (5@#$%&-[ta]gataa-3@#$%&) found in the larval promoters of all known alcohol dehydrogenase (adh) genes. acts as a homeotic gene downstream of the terminal gap gene hkb to promote morphogenesis and differentiation of anterior and posterior midgut.
1565	may be involved in cell-cell adhesion and signal transduction.
1566	
1567	couples the p55 tnf-receptor (tnf-r55 / tnfr1) to neutral sphingomyelinase (n-smase). specifically binds to the n- smase activation domain of tnf-r55. may regulate ceramide production by n-smase.
1568	involved in control of the cell cycle. upon lytic infection of permissive cells, the hsv transactivator protein vp16 associates with hcfc1. binding to hcfc1 activates vp16 for association with the octamer motif-binding protein pou2f1, to form a multiprotein-dna complex responsible for activating transcription of the hsv immediate early genes. also antagonizes transactivation by zbtb17 and gabp2; represses zbtb17 activation of the p15(ink4b) promoter and inhibits its ability to recruit p300. coactivator for egr2 and gabp2. tethers the chromatin modifying set1/ash2 histone h3-k4 methyltrasferase (hmt) and sin3 histone deacetylase (hdac) complexes (involved in the activation and repression of transcription, respectively) together.
1569	
1570	docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. dok2 may modulate the cellular proliferation induced by il-4, as well as il-2 and il-3. may be involved in modulating bcr-abl signaling. attenuates egf- stimulated map kinase activation (by similarity).
1571	
1572	hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. may play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
1573	induces apoptosis. interacts with viral and cellular anti-apoptosis proteins. can overcome the suppressors bcl-2 and bcl-xl, although high levels of bcl-xl expression will inhibit apoptosis. may function as a tumor suppressor.
1574	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
1575	
1576	
1577	
1578	
1579	
1580	
1581	converts udp and glcnac-1-p into udp-glcnac, and udp and galnac-1-p into udp-galnac. isoform agx1 has 2 to 3 times higher activity towards galnac-1-p, while isoform agx2 has 8 times more activity towards glcnac-1-p.
1582	stimulates the dissociation of gdp from the ras-related rala and ralb gtpases which allows gtp binding and activation of the gtpases. interacts and acts as an effector molecule for r-ras, h-ras, k-ras, and rap.
1583	transcriptional corepressor that binds to a number of transcription factors. inhibits nf-kappa-b-regulated gene expression. inhibits the transcriptional activation mediated by foxa2, and by ctnnb1 and tcf family members in wnt signaling. the effects of full-length tle family members may be modulated by association with dominant-negative aes. unusual function as coactivator for esrrg.
1584	chemotactic factor that attracts skin-associated memory t-lymphocytes. may play a role in mediating homing of lymphocytes to cutaneous sites. binds to ccr10.
1585	
1586	necessary for protein translocation in the endoplasmic reticulum.
1587	
1588	
1589	
1590	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
1591	
1592	putative atp-dependent protease.
1593	activates cdc42, a member of the ras-like family of rho- and rac proteins, by exchanging bound gdp for free gtp. plays a role in regulating the actin cytoskeleton and cell shape.
1594	dorsalizing factor. key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing tgf-beta family bone morphogenetic proteins (bmps) and sequestering them in latent complexes (by similarity).
1595	chloride channel or a regulator or accessory subunit of other proteins that could provide the pore-froming function.
1596	chloride channel or a regulator or accessory subunit of other proteins that could provide the pore-froming function.
1597	adds the second glucose residue to the lipid-linked oligosaccharide precursor for n-linked glycosylation. transfers glucose from dolichyl phosphate glucose (dol-p-glc) onto the lipid-linked oligosaccharide glc(1)man(9)glcnac(2)-pp-dol (by similarity).
1598	involved in pyrimidine base degradation. catalyzes the reduction of uracil and thymine. also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
1599	syntaxin that may be involved in targeting and fusion of golgi-derived retrograde transport vesicles with the er.
1600	involved in the apoptotic response after nerve growth factor (ngf) binding in neuronal cells. binds p75ntr and antagonizes its association with trka, inhibits cell cycle progression, and facilitates p75ntr-mediated apoptosis. may act as a regulator of the function of dlx family members. may regulate p53 transcriptional activity and inhibit cell proliferation. enhances p53 phosphorylation and accumulation.
1601	
1602	potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. the effects of betacellulin are probably mediated by the egf receptor and other related receptors.
1603	
1604	
1605	phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eif2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. serves as a critical effector of unfolded protein response (upr)-induced g1 growth arrest due to the loss of cyclin d1 (by similarity).
1606	
1607	participates to the mitochondrial proton leak measured in brain mitochondria.
1608	plays a major role in organizing spindle poles.
1609	
1610	
1611	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
1612	hcnp may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. hcnp increases the production of choline acetyltransferase but not acetylcholinesterase. seems to be mediated by a specific receptor (by similarity).
1613	
1614	serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (ir), ultraviolet light (uv), or dna replication stalling, thereby acting as a dna damage sensor. recognizes the substrate consensus sequence [s/t-q]. phosphorylates brca1, chek1, mcm2, rad17, rpa2, smc1 and tp53/p53, which collectively inhibit dna replication and mitosis and promote dna repair, recombination and apoptosis. phosphorylates ser-139 of histone variant h2ax/h2afx at sites of dna damage, thereby regulating dna damage response mechanism. required for fancd2 ubiquitination. critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
1615	fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
1616	may have a regulatory role in phosphatidylcholine synthesis.
1617	low affinity receptor for granulocyte-macrophage colony- stimulating factor. transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
1618	
1619	
1620	component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix.
1621	
1622	
1623	
1624	upon binding to egf receptor enhances egf-dependent mitogenic signals. can bind multiple cellular targets.
1625	
1626	
1627	possible cell death inducer, in association with other factors.
1628	activates progelatinase a. may also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. cleaves partially fibronectin, but not collagen type i, nor laminin.
1629	specifically binds to the upstream regulatory region of type i ifn and ifn-inducible mhc class i genes (the interferon consensus sequence (ics)) and represses those genes.
1630	
1631	this is a membrane-bound, calcium-inhibitable adenylyl cyclase.
1632	
1633	its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites.
1634	
1635	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
1636	
1637	
1638	apod occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. it is probably involved in the transport and binding of bilin. appears to be able to transport a variety of ligands in a number of different contexts.
1639	
1640	essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. required for the assembly of the dynein-dynactin complex onto kinetochores.
1641	may be involved in transcriptional regulation.
1642	
1643	not known, though may play a role in tumor or aspects of tumor progression.
1644	binds specifically to nuclear core particles and acts as a transcriptional activator (by similarity).
1645	
1646	could be a guanine-nucleotide releasing factor.
1647	plays a role in the formation of functional neural circuits from the early stages of synapse formation. has a role in the development of cns functions involved in locomotor activity.
1648	
1649	not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
1650	
1651	enzyme which catalyzes the acetylation of polyamines. substrate specificity: norspermidine = spermidine >> spermine > n(1)acetylspermine > putrescine. this highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. also involved in the regulation of polyamine transport out of cells.
1652	eif-2 functions in the early steps of protein synthesis by forming a ternary complex with gtp and initiator trna. this complex binds to a 40s ribosomal subunit, followed by mrna binding to form a 43s preinitiation complex. junction of the 60s ribosomal subunit to form the 80s initiation complex is preceded by hydrolysis of the gtp bound to eif-2 and release of an eif-2-gdp binary complex. in order for eif-2 to recycle and catalyze another round of initiation, the gdp bound to eif-2 must exchange with gtp by way of a reaction catalyzed by eif-2b.
1653	
1654	
1655	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
1656	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
1657	
1658	plays a crucial role in b-cell ontogeny. transiently phosphorylates gtf2i on tyrosine residues in response to b-cell receptor crosslinking.
1659	required for ribosome biogenesis and telomere maintenance. probable catalytic subunit of h/aca small nucleolar ribonucleoprotein (h/aca snornp) complex, which catalyzes pseudouridylation of rrna. this involves the isomerization of uridine such that the ribose is subsequently attached to c5, instead of the normal n1. each rrna can contain up to 100 pseudouridine (@#$%&psi@#$%&) residues, which may serve to stabilize the conformation of rrnas. also required for correct processing or intranuclear trafficking of terc, the rna component of the telomerase reverse transcriptase (tert) holoenzyme.
1660	plays an important role in the organization of the cytoskeleton. binds to and sequesters actin monomers (g actin) and therefore inhibits actin polymerization (by similarity).
1661	activates ubiquitin by first adenylating with atp its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in e1, yielding an ubiquitin-e1 thioester and free amp.
1662	may play a role in spermatogenesis (by similarity).
1663	not yet known, orphan transporter.
1664	stimulates exchange activity on rho proteins in vitro, but not on cdc42, ras or rac. may bind calcium ions.
1665	
1666	c1q associates with the proenzymes c1r and c1s to yield c1, the first component of the serum complement system. the collagen-like regions of c1q interact with the ca(2+)-dependent c1r(2)c1s(2) proenzyme complex, and efficient activation of c1 takes place on interaction of the globular heads of c1q with the fc regions of igg or igm antibody present in immune complexes.
1667	id (inhibitor of dna binding) hlh proteins lack a basic dna-binding domain but are able to form heterodimers with other hlh proteins, thereby inhibiting dna binding. id-3 inhibits the binding of e2a-containing protein complexes to muscle creatine kinase e-box enhancer. may inhibit other transcription factors.
1668	mbp1 binds to the c-myc promoter and acts as a transcriptional repressor. may be a tumor suppressor.
1669	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein (by similarity).
1670	proteolytically removes the c-terminal three residues of farnesylated proteins. acts on lamin a/c.
1671	
1672	
1673	may play a role in organizing the actin cytoskeleton of the brain cells.
1674	required for activity at the locus control region (lcr) upstream of the globin gene complexes. requires p18 nf-e2 for binding to the nf-e2 motif. may play a role in all aspects of hemoglobin production: globin synthesis, heme synthesis, and the procurement of iron.
1675	
1676	may play an important role in the capacity of cells to respond to and cope with changes in their environment. may play a role in tissue remodeling and defense against pathogens.
1677	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
1678	ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. mediates the interaction of activated endothelial cells or platelets with leukocytes. the ligand recognized is sialyl-lewis x.
1679	
1680	has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. may share a common physiologic function with the plasma-type enzyme.
1681	
1682	communication between transverse-tubules and sarcoplasmic reticulum. contraction of cardiac muscle is triggered by release of calcium ions from sr following depolarization of t- tubules (by similarity).
1683	proton-conducting pore forming subunit of the membrane integral v0 complex of vacuolar atpase. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
1684	
1685	
1686	
1687	isoform 7 behaves as a receptor and binds the secreted isoform 5. the binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. can bind to grb2 adapter protein.
1688	involved in transport of proteins into the mitochondrion. essential for embryonic development (by similarity).
1689	seems to be required for maximal rate of protein biosynthesis. enhances ribosome dissociation into subunits and stabilizes the binding of the initiator met-trna(i) to 40 s ribosomal subunits.
1690	histone h3, along with histone h4, plays a central role in nucleosome formation.
1691	may act as a transcriptional activator/repressor in the myeloid lineage. plays a role in the granulocyte/monocyte cell- specific response to interferon. stimulates the dna binding of the transcriptional repressor protein yy1.
1692	receptor for progesterone (by similarity). may be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) immunotoxicity.
1693	
1694	because s100a10 induces the dimerization of anxa2/p36, it may function as a regulator of protein phosphorylation in that the anxa2 monomer is the preferred target (in vitro) of tyrosine- specific kinase.
1695	shows growth cone collapsing activity on dorsal root ganglion (drg) neurons in vitro. may be a stop signal for the drg neurons in their target areas, and possibly also for other neurons. may also be involved in the maintenance and remodeling of neuronal connections.
1696	
1697	
1698	creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
1699	
1700	
1701	has antiproliferative properties in human melanoma cells and may contribute to terminal cell differentiation. may also function as a negative regulator of melanoma progression. formation in vivo in nude mice. they found that it selectively induces apoptosis in human breast cancer cells.
1702	
1703	
1704	thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. it is capable of binding to actin, calmodulin, troponin c and tropomyosin. the interaction of calponin with actin inhibits the actomyosin mg-atpase activity.
1705	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
1706	probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. when overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. may act by activating both map kinase and phosphatidylinositol 3@#$%&-kinases (pi3k) pathways (by similarity).
1707	
1708	
1709	ligand of the t-lymphocyte cd2 glycoprotein. this interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of t-lymphocytes with target cells and antigen- presenting cells and the t-lymphocyte rosetting with erythrocytes. in addition, the lfa-3/cd2 interaction may prime response by both the cd2+ and lfa-3+ cells.
1710	
1711	
1712	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i.
1713	
1714	
1715	plays a key role in the control of the eukaryotic cell cycle. it is required in higher cells for entry into s-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive c-terminus of rna polymerase ii.
1716	
1717	may be involved in cell-cell interactions.
1718	catalyzes the conversion of aldehydes and ketones to alcohols. catalyzes the reduction of prostaglandin (pg) d2, pgh2 and phenanthrenequinone (pq) and the oxidation of 9alpha,11beta- pgf2 to pgd2. functions as a bi-directional 3alpha-, 17beta- and 20alpha hsd. can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. preferentially transforms androstenedione (4-dione) to testosterone.
1719	
1720	apoptosis-inducing protein that, which can overcome bcl- 2 suppression.
1721	plays a key role in retinoic acid metabolism. acts on retinoids, including all-trans-retinoic acid (ra) and its stereoisomer 9-cis-ra. capable of both 4-hydroxylation and 18- hydroxylation. responsible for generation of several hydroxylated forms of ra, including 4-oh-ra, 4-oxo-ra and 18-oh-ra.
1722	may be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (by similarity).
1723	adds a myristoyl group to the n-terminal glycine residue of certain cellular and viral proteins.
1724	adds a myristoyl group to the n-terminal glycine residue of certain cellular and viral proteins.
1725	alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of g proteins. the rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. for antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
1726	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. associates specifically with the activated forms of the g protein subunits g(i)-alpha and g(z)- alpha but fails to interact with the structurally and functionally distinct g(s)-alpha subunit. activity on g(z)-alpha is inhibited by palmitoylation of the g-protein.
1727	
1728	
1729	muscle contraction.
1730	
1731	
1732	catalytic subunit of the nua4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. nua4 may also play a direct role in dna repair when recruited to sites of dna damage. directly acetylates and activates atm. direct binding of htatip to the tat protein of the human immunodeficiency virus (hiv) might be an important feature for efficient tat transactivation of hiv gene expression.
1733	
1734	the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the er, via the golgi up to the trans golgi network. coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-er transport of dilysine-tagged proteins. in mammals, the coatomer can only be recruited by membranes associated to adp-ribosylation factors (arfs), which are small gtp-binding proteins; the complex also influences the golgi structural integrity, as well as the processing, activity, and endocytic recycling of ldl receptors (by similarity).
1735	degrades collagen type i. does not act on gelatin or casein. could have a role in tumoral process.
1736	possible involved in germ cell rna processing and meiosis.
1737	
1738	
1739	transcription factor that binds to the octamer motif (5@#$%&-atttgcat-3@#$%&). activates cytokeratin 10 (k10) gene expression. may serve a regulatory function with respect to epidermal development. isoform 2 inhibits transactivation by oct-1.
1740	
1741	the insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.
1742	activation of the c1 complex is under control of the c1- inhibitor. it forms a proteolytically inactive stoichiometric complex with the c1r or c1s proteases. may play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins.
1743	
1744	potentially involved in docking of synaptic vesicles at presynaptic active zones.
1745	involved in cell adhesion. binds to cd166.
1746	
1747	resistance to tetracycline by an active tetracycline efflux. this is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. this protein functions as a metal-tetracycline/h(+) antiporter.
1748	during embryonic development, some isoforms are essential for proper neuronal differentiation and organization. required for cell polarity; maintenance of apicobasal polarity. plays a critical role at septate junctions in cellular growth control during larval development. the presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
1749	
1750	
1751	
1752	
1753	
1754	involved in transcriptional regulation. represses the transcription of a number of genes including gastrin, stromelysin and enolase. binds to the g-rich box in the enhancer region of these genes.
1755	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. the alpha and alpha@#$%& chains contain the catalytic site. participates in wnt signaling. ck2 phosphorylates ser-392 of p53/tp53 following uv irradiation.
1756	
1757	
1758	links t-cell receptor activation signal to phospholipase c-gamma-1, grb-2 and phosphatidylinositol 3-kinase (by similarity).
1759	this antigen is associated with early stages of melanoma tumor progression. may play a role in growth regulation.
1760	
1761	may be a transcriptional repressor that represses both basal and activated transcription.
1762	constituent of copii-coated endoplasmic reticulum- derived transport vesicles. required for efficient transport of a subset of secretory proteins to the golgi. the c-terminal ile-leu motif is required for exit from the endoplasmic reticulum. facilitates retrograde transport from the golgi to the endoplasmic reticulum.
1763	most effectively accelerate the intrinsic gtpase activity of ypt7. it is also active, but to a lesser extent, on ypt31, ypt32 and ypt1. ypt6 and sec4.
1764	
1765	
1766	facilitative glucose transporter. probably a neuronal glucose transporter.
1767	is able to inhibit all four classes of proteinases by a unique @#$%&trapping@#$%& mechanism. this protein has a peptide stretch, called the @#$%&bait region@#$%& which contains specific cleavage sites for different proteinases. when a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. the entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
1768	cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
1769	inactivates map kinases. has a specificity for the erk family.
1770	receptor for tnfsf2/tnf-alpha and homotrimeric tnfsf1/lymphotoxin-alpha. the adapter molecule fadd recruits caspase-8 to the activated receptor. the resulting death-inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. contributes to the induction of noncytocidal tnf effects including anti-viral state and activation of the acid sphingomyelinase.
1771	probably methylates the guanidino nitrogens of arginyl residues in some proteins (by similarity).
1772	binds to the il-1 type i receptor following il-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mrna stabilization. the kinase activity of this enzyme may not be required for il-1 signaling. once phosphorylated, irak1 recruits the adapter protein peli1.
1773	
1774	rna binding protein that regulates the expression of target mrnas at the translation level. regulates expression of the notch1 antagonist numb. binds rna containing the sequence 5@#$%&- guuaguuaguuaguu-3@#$%& and other sequences containing the pattern 5@#$%&- [ga]u(1-3)agu-3@#$%&. may play a role in the proliferation and maintenance of stem cells in the central nervous system (by similarity).
1775	
1776	essential for the control of the cell cycle at the g1/s (start) transition.
1777	specifically removes c-terminal basic residues (arg or lys) from peptides and proteins. it is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.
1778	plays a role in lipoprotein assembly and dietary cholesterol absorption. in addition to its acyltransferase activity, it may act as a ligase. may provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
1779	
1780	
1781	
1782	
1783	a spliceosome-associated protein; may play a role in cross-intron bridging of u1 and u2 snrnps in the mammalian a complex.
1784	
1785	appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles.
1786	
1787	subunit of the peripheral v1 complex of vacuolar atpase. vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (by similarity).
1788	
1789	
1790	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.
1791	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
1792	
1793	
1794	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules.
1795	may be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.
1796	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
1797	
1798	
1799	
1800	
1801	acts as a transcriptional repressor. may be involved in dna damage-inducible cell cycle arrests (checkpoints).
1802	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
1803	may be involved in transferrin trafficking. likely to power actin-based membrane trafficking in many physiologically crucial tissues.
1804	acyl-coa synthetase probably involved in bile acid metabolism. proposed to activate c27 precurors of bile acids to their coa thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. in vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (thca), the c27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. does not utilize c24 bile acids as substrates. in vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. may be involved in translocation of long-chain fatty acids (lfca) across membranes (by similarity).
1805	
1806	
1807	
1808	atp-dependent specificity component of the clp protease. it directs the protease to specific substrates. can perform chaperone functions in the absence of clpp (by similarity).
1809	
1810	
1811	
1812	
1813	essential component of nuclear pore complex. required for the assembly of peripheral proteins into the nuclear pore complex.
1814	
1815	
1816	tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
1817	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
1818	
1819	
1820	
1821	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. this subunit is involved in antigen processing to generate class i binding peptides.
1822	
1823	
1824	
1825	
1826	
1827	
1828	carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria (by similarity).
1829	
1830	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
1831	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
1832	
1833	may be involved in transcriptional regulation.
1834	
1835	acts as a multispecific organic anion pump which can transport nucleotide analogs (by similarity).
1836	major enzyme for galactose metabolism.
1837	highly selective for arachidonate-containing species of diacylglycerol (dag). may terminate signals transmitted through arachidonoyl-dag or may contribute to the synthesis of phospholipids with defined fatty acid composition.
1838	
1839	
1840	
1841	
1842	
1843	may be involved in transcriptional regulation.
1844	
1845	tfiif is a general transcription initiation factor that binds to rna polymerase ii and helps to recruit it to the initiation complex in collaboration with tfiib. it promotes transcription elongation. this subunit shows atp-dependent dna- helicase activity.
1846	phosphorylates specifically ribosomal protein s6 in response to insulin or several classes of mitogens.
1847	
1848	
1849	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
1850	cbf binds to the core site, 5@#$%&-pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, lck, il-3 and gm-csf promoters. the alpha subunit binds dna and appears to have a role in the development of normal hematopoiesis. isoform aml-1l interferes with the transactivation activity of runx1. acts synergistically with elf4 to transactivate the il-3 promoter and with elf2 to transactivate the mouse blk promoter. inhibits myst4- dependent transcriptional activation.
1851	
1852	acts as a transcriptional activator of the c-myc gene; binds dna nonspecifically (ref.3).
1853	may inhibit tumor metastasis (by similarity). in vitro, reduces cell motility.
1854	
1855	
1856	
1857	
1858	
1859	
1860	transcription factor that controls the expression of the th1 cytokine, interferon-gamma. initiates th1 lineage development from naive th precursor cells both by activating th1 genetic programs and by repressing the opposing th2 programs.
1861	
1862	glycosyltransferase required for the biosynthesis of heparan-sulfate. the ext1/ext2 complex possesses substantially higher glycosyltransferase activity than ext1 or ext2 alone. appears to be a tumor suppressor.
1863	the normal physiological role of blm hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug blm (a glycopeptide) by hydrolyzing the carboxamide bond of its b- aminoalaninamide moiety thus protecting normal and malignant cells from blm toxicity (by similarity).
1864	may be involved in processing of pre-ribosomal rna.
1865	orphan receptor. could be a chemokine receptor.
1866	
1867	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
1868	
1869	
1870	
1871	cytokine that binds to tnfrsf13b/taci and tnfrsf17/bcma. tnfsf13/april binds to the same 2 receptors. together, they form a 2 ligands -2 receptors pathway involved in the stimulation of b- and t-cell function and the regulation of humoral immunity. a third b-cell specific baff-receptor (baffr/br3) promotes the survival of mature b-cells and the b-cell response.
1872	required for vesicular transport between the endoplasmic reticulum and the golgi apparatus.
1873	required for vesicular transport between the endoplasmic reticulum and the golgi apparatus.
1874	
1875	might function as an inhibitor of lys-specific proteases. might influence the maturation of megakaryocytes via its action as a serpin.
1876	
1877	accepts the ubiquitin-like protein nedd8 from the ube1c- appbp1 e1 complex and catalyzes its covalent attachment to other proteins. involved in cell proliferation.
1878	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
1879	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
1880	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
1881	
1882	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
1883	
1884	
1885	
1886	involved in redox regulation of the cell. reduces peroxides with reducing equivalents provided through the thioredoxin system. it is not able to receive electrons from glutaredoxin. may play an important role in eliminating peroxides generated during metabolism. might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of h(2)o(2).
1887	
1888	orphan receptor.
1889	
1890	
1891	
1892	transcription activator for a number of liver genes such as afp, albumin, tyrosine aminotransferase, pepck, etc. interacts with the cis-acting regulatory regions of these genes.
1893	
1894	
1895	may antagonize nodal signaling and subsequent organization of axial structures during mesodermal patterning (by similarity).
1896	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb (by similarity).
1897	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb (by similarity).
1898	seems to play an essential role in cold-induced suppression of cell proliferation.
1899	
1900	
1901	
1902	
1903	
1904	
1905	
1906	
1907	transcriptional inhibitor that binds to dna sequence 5@#$%&- cacct-3@#$%& in different promoters (by similarity).
1908	enzyme with a broad specificity.
1909	crystallins are the dominant structural components of the vertebrate eye lens.
1910	associates with the ryanodine receptor (ryr-2) in cardiac muscle sarcoplasmic reticulum and may play a unique physiological role in excitation-contraction coupling in cardiac muscle. there are four molecules of fkbp12.6 per heart muscle ryr. has the potential to contribute to the immunosuppressive and toxic effects of fk506 and rapamycin. ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
1911	
1912	likely to play an important role in intracellular protein and peptide metabolism.
1913	
1914	
1915	required for membrane traffic to the vacuole.
1916	following activation by double-stranded rna in the presence of atp, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor eif2s1, which leads to an inhibition of the initiation of protein synthesis. double-stranded rna is generated during the course of a viral infection.
1917	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the complex p170-eif3.
1918	
1919	v-snare that mediates vesicle transport pathways through interactions with t-snares on the target membrane. these interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.
1920	
1921	segment polarity protein, functions together with arm to transduce the wingless (wg) signal. acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
1922	
1923	
1924	gtpase activator for the rho-type gtpases by converting them to an inactive gdp-bound state (by similarity).
1925	may play a role in neuron-specific rna processing.
1926	
1927	
1928	probable atpase involved in the assembly or function of nuclear protein complexes. may also be involved in some aspects of microtubule dynamics (by similarity).
1929	
1930	may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (by similarity).
1931	id (inhibitor of dna binding) hlh proteins lack a basic dna-binding domain but are able to form heterodimers with other hlh proteins, thereby inhibiting dna binding. id-2 may be an inhibitor of tissue-specific gene expression.
1932	collagen type iii occurs in most soft connective tissues along with type i collagen.
1933	stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal dna fragmentation.
1934	important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. specifically binds to an il-1 response element in the il-6 gene. nf-il6 also binds to regulatory regions of several acute-phase and cytokines genes. it probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. the consensus recognition site is 5@#$%&-t[tg]nngnaa[tg]-3@#$%&.
1935	may play a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. there are four molecules of fkbp12 per skeletal muscle ryr. ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
1936	
1937	induces cartilage and bone formation.
1938	
1939	required for protein transport from the er to the golgi complex.
1940	
1941	
1942	
1943	
1944	this protein seems to be part of the stalk that links cf(0) to cf(1). it either transmits conformational changes from cf(0) into cf(1) or is implicated in proton conduction.
1945	part of the complex catalyzing the transfer of n- acetylglucosamine from udp-n-acetylglucosamine to phosphatidylinositol, the first step of gpi biosynthesis.
1946	
1947	weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. binds to and initiates the activation of stk38 by releasing autoinhibitory intramolecular interactions within the kinase.
1948	subunit of the peripheral v1 complex of vacuolar atpase essential for assembly or catalytic function. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
1949	clathrin is the major protein of the polyhedral coat of coated pits and vesicles. two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-golgi network (by similarity).
1950	may have a role in early embryogenesis.
1951	
1952	enhances nf-kappa-b, srf and ap1 transactivation.
1953	
1954	
1955	
1956	
1957	
1958	this protein binds the hiv-1 tata element and inhibits transcriptional activation by the tata-binding protein (tbp).
1959	
1960	could be involved in normal hemopoietic differentiation as well as in erythroid/myeloid lineage switching (by similarity).
1961	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of the calcium.
1962	
1963	inhibits the auto- and transphosphorylation activity of btk. plays a negative regulatory role in btk-related cytoplasmic signaling in b-cells. may be involved in bcr-induced apoptotic cell death.
1964	its binding to fibronectin and some other ligands is calcium dependent.
1965	
1966	stratified squamous epithelial basement membrane protein that form anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ecm) proteins such as type iv collagen.
1967	
1968	
1969	
1970	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
1971	required for preprotein translocation (by similarity).
1972	component of the cop9 signalosome complex (csn), a complex involved in various cellular and developmental processes. the csn complex is an essential regulator of the ubiquitin (ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of scf-type e3 ligase complexes, leading to decrease the ubl ligase activity of scf-type complexes such as scf, csa or ddb2. the complex is also involved in phosphorylation of p53/tp53, c-jun/jun, ikappabalpha/nfkbia, itpk1 and irf8/icsbp, possibly via its association with ck2 and pkd kinases. csn-dependent phosphorylation of tp53 and jun promotes and protects degradation by the ubl system, respectively.
1973	receptor that accelerates the import of all mitochondrial precursor proteins (by similarity).
1974	muscle contraction.
1975	
1976	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
1977	
1978	
1979	thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. during neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. slit1 and slit2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. in spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. in vitro, silences the attractive effect of ntn1 but not its growth- stimulatory effect and silencing requires the formation of a robo1-dcc complex. may be implicated in spinal chord midline post- crossing axon repulsion. in vitro, only commissural axons that crossed the midline responded to slit2. in the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. in vitro, collapses and repels retinal ganglion cell growth cones. seems to play a role in branching and arborization of cns sensory axons, and in neuronal cell migration. in vitro, slit homolog 2 protein n-product, but not slit homolog 2 protein c-product, repels olfactory bulb (ob) but not dorsal root ganglia (drg) axons, induces ob growth cones collapse and induces branching of drg axons. seems to be involved in regulating leukocyte migration.
1980	
1981	
1982	catalyzes the initial reaction in o-linked oligosaccharide biosynthesis, the transfer of an n-acetyl-d- galactosamine residue to a serine or threonine residue on the protein receptor. has a broad spectrum of substrates for peptides such as ea2, muc5ac, muc1a, muc1b and muc7.
1983	may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.
1984	
1985	bifunctional enzyme with both atp sulfurylase and aps kinase activity, which mediates two steps in the sulfate activation pathway. the first step is the transfer of a sulfate group to atp to yield adenosine 5@#$%&-phosphosulfate (aps), and the second step is the transfer of a phosphate group from atp to aps yielding 3@#$%&-phosphoadenylylsulfate (paps: activated sulfate donor used by sulfotransferase). in mammals, paps is the sole source of sulfate; aps appears to be only an intermediate in the sulfate- activation pathway. also involved in the biosynthesis of sulfated l-selectin ligands in endothelial cells.
1986	may function as an antagonist of fibroblast growth factor (fgf) pathways and may negatively modulate respiratory organogenesis.
1987	
1988	phosphorylates eukaryotic elongation factor-2. binds calmodulin (by similarity).
1989	
1990	
1991	aminopeptidase n is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
1992	may be involved in transcriptional regulation. plays a role during development and organogenesis as well as in the function of the adult central nervous system (by similarity).
1993	
1994	
1995	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
1996	
1997	
1998	forms a channel through the mitochondrial outer membrane and also the plasma membrane. the channel allows diffusion of small hydrophilic molecules; it adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mv. the open state has a weak anion selectivity whereas the closed state is cation-selective. may participate in the formation of the permeability transition pore complex (ptpc) responsible for the release of mitochondrial products that triggers apoptosis.
1999	
2000	probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. is not an essential protein. involved in substrate recognition in ubiquitin-dependent degradation.
2001	may have potent implications in lung endothelial cell- leukocyte interactions.
2002	
2003	
2004	controls the flux of glucose into the hexosamine pathway. most likely involved in regulating the availability of precursors for n- and o-linked glycosylation of proteins.
2005	
2006	may play a role in intercellular signaling and in connecting cells with the extracellular matrix. may take part in the regulation of cell motility, growth and differentiation. binds hyaluronic acid.
2007	
2008	may act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (nr). isoform 2 stimulates transcriptional activation by ar/dhtr, esr1/nr3a1, rxra/nr2b1 and thrb/erba2. at least isoform 1 and isoform 2 are components of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. nua4 may also play a direct role in dna repair when recruited to sites of dna damage.
2009	beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of g proteins. the beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
2010	catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues.
2011	
2012	involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)u34) of the wobble uridine base in mitochondrial trnas.
2013	nuclear receptor coactivator. may play a role in signal transduction.
2014	
2015	molecular chaperone. has atpase activity (by similarity).
2016	modulates the action of platelet-activating factor (paf) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-paf. has a specificity for substrates with a short residue at the sn-2 position. it is inactive against long-chain phospholipids.
2017	
2018	
2019	may be a dna-binding protein with a regulatory function. may play an important role in cell death and/or in regulation of cell proliferation.
2020	may be a dna-binding protein with a regulatory function. may play an important role in cell death and/or in regulation of cell proliferation.
2021	
2022	could be involved with trophinin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.
2023	has broad antibacterial activity. may contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
2024	
2025	
2026	involved in the presentation of foreign antigens to the immune system.
2027	possible regulatory or functional link with the histocompatibility cluster.
2028	type i collagen is a member of group i collagen (fibrillar forming collagen).
2029	
2030	in the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the a repressor bcl-2 or its adenovirus homolog e1b 19k protein.
2031	involved in vesicular protein trafficking.
2032	responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. plays a role in the regulation of protein translation by phosphorylating and inactivating eef2k.
2033	
2034	may play a role in transcriptional regulation. binds to and activates cyclin-dependent kinase cdk8 that phosphorylates the ctd (carboxy-terminal domain) of the large subunit of rna polymerase ii (rnap ii).
2035	alpha-l-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end n- acetylglucosamine of the carbohydrate moieties of glycoproteins (by similarity).
2036	cell autonomous negative regulator of lin-12/notch- mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. may function as part of an e3 complex to target the intracellular domains of lin-12/notch proteins for ubiquitin-dependent degradation.
2037	probable sugar transporter (by similarity).
2038	
2039	
2040	extremely potent competitive inhibitor of camp-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the camp-induced dissociation of its regulatory chains (by similarity).
2041	catalyzes the covalent attachment of ubiquitin to other proteins. capable, in vitro, to ubiquitinate histone h2a.
2042	
2043	
2044	receptor for the glycosphingolipid psychosine (psy) and several related glycosphingolipids. may have a role in activation- induced cell death or differentiation of t-cells.
2045	
2046	required for maximal atpase activity of brg1 and are also required with brg1 for association of the complex with chromatin/matrix (by similarity).
2047	
2048	does not act as an allosteric activator of the cholera toxin catalytic subunit (by similarity).
2049	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
2050	
2051	
2052	
2053	may be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction enhances wnt signaling and inhibits tgf-beta signaling (by similarity). directly antagonizes activity of bmp2, bmp4, bmp6 and bmp7 in a dose-dependent manner.
2054	
2055	
2056	
2057	
2058	
2059	kinase-defective receptor for members of the ephrin-b family.
2060	catalyzes the phosphorylation of thiamine to thiamine pyrophosphate.
2061	catalyzes the o-sulfation of tyrosine residues within acidic motifs of polypeptides.
2062	
2063	
2064	responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain.
2065	subunit of the peripheral v1 complex of vacuolar atpase. subunit c is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
2066	plays a role in papillomavirus genes transcription.
2067	maintains high levels of reduced glutathione in the cytosol.
2068	
2069	growth factor active on keratinocytes. possible major paracrine effector of normal epithelial cell proliferation.
2070	dual specificity phosphatase that dephosphorylates map kinase fus3 on both a tyr and a ser or thr. has a role in adaptation to pheromone.
2071	subunit of the integral membrane v0 complex of vacuolar atpase. vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.
2072	involved in ribosome biogenesis (by similarity).
2073	the primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (vldl). the enzyme functions in the presence of apolipoprotein c-2 on the luminal surface of vascular endothelium.
2074	may play a role in neuronal differentiation, and in modulating membrane interaction with the cytoskeleton during neurite outgrowth.
2075	catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
2076	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
2077	participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles.
2078	
2079	transfers mannosyl residues to the hydroxyl group of serine or threonine residues. coexpression of both pomt1 and pomt2 is necessary for enzyme activity, expression of either pomt1 or pomt2 alone is insufficient.
2080	component of the elastin-associated microfibrils.
2081	
2082	
2083	
2084	cysteine protease. may have an important role in corneal physiology.
2085	
2086	implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2a, regulation of mrna trafficking and stability in association with elavl1, and inhibition of acetyltransferases as part of the inhat (inhibitor of histone acetyltransferases) complex.
2087	
2088	
2089	catalyzes the conversion of pgh2 to pgd2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. involved in a variety of cns functions, such as sedation, nrem sleep and pge2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. it is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
2090	
2091	
2092	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
2093	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release. has anti-apoptotic activity. markedly increases the anti-cell death function of bcl2 induced by various stimuli.
2094	may be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. may also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
2095	
2096	synthesizes selenophosphate from selenide and atp.
2097	
2098	
2099	
2100	
2101	
2102	
2103	shows moderate inhibition of cathepsin b but is not active against cathepsin c.
2104	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
2105	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
2106	
2107	
2108	attaches integral membrane proteins to cytoskeletal elements. also binds to cytoskeletal proteins. required for coordinate assembly of na/ca exchanger, na/k atpase and insp3 receptor at sarcoplasmic reticulum sites in cardiomyocytes.
2109	
2110	
2111	
2112	calcium channel protein which plays an important role in excitation-contraction coupling.
2113	calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. it may act in assisting protein assembly and/or in the retention within the er of unassembled protein subunits. it seems to play a major role in the quality control apparatus of the er by the retention of incorrectly folded proteins.
2114	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
2115	
2116	
2117	in the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing non-specifically a variety of target cells.
2118	
2119	probable motor protein.
2120	cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. dynein has atpase activity; the force-producing power stroke is thought to occur on release of adp.
2121	
2122	cleaves the large aggregating proteoglycans, aggrecan and versican.
2123	
2124	
2125	
2126	stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
2127	necessary for efficient rna polymerase ii transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by s-ii allows the resumption of elongation from the new 3@#$%&terminus.
2128	component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix.
2129	
2130	important for the overall degradation of proteins in lysosomes.
2131	may be involved in transcriptional regulation.
2132	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
2133	
2134	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. the produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
2135	
2136	
2137	
2138	
2139	
2140	
2141	probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. recognizes and binds to the dna sequence 5@#$%&-atgcaaat-3@#$%&. isoform 1 does not bind dna.
2142	
2143	
2144	may be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. may also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
2145	component of pa700, an atp-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20s proteasome) of the 26s complex. specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone t3-independent manner) and with retinoid x receptor (rxr). could be e3 ubiquitin- protein ligase which accepts ubiquitin from an e2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
2146	inhibitor of the wnt signaling pathway. down-regulates beta-catenin. probably facilitate the phosphorylation of beta- catenin and apc by gsk3b (by similarity).
2147	regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair (by similarity).
2148	
2149	fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
2150	
2151	
2152	
2153	has an effect on position-effect variegation.
2154	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. has angiogenic inhibitor activity (by similarity). active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture (by similarity).
2155	
2156	may be involved in n-glycosylation through its association with n-oligosaccharyl transferase.
2157	
2158	
2159	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
2160	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
2161	
2162	probably involved in ubiquitination and subsequent proteasomal degradation of target proteins. plays a role in the polyubiquitination of cdt1 in response to radiation-induced dna damage.
2163	motor protein that translocates prc1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. may play a role in mitotic chromosomal positioning and bipolar spindle stabilization.
2164	acts as a negative coregulator for lim homeodomain transcription factors. via the recruitment of the sin3a/histone deacetylase corepressor complex.
2165	involved in the degradation of asparagine-linked glycoproteins. hydrolyze of n-acetyl-beta-d-glucosamine (1-4)n- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.
2166	
2167	the exact function of this protein is not known. it is probably a receptor with a tyrosine-protein kinase activity.
2168	
2169	involved in the export of mrna from the nucleus to the cytoplasm.
2170	
2171	activates ubiquitin by first adenylating with atp its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in e1, yielding an ubiquitin-e1 thioester and free amp.
2172	seems to be required for maximal rate of protein biosynthesis. enhances ribosome dissociation into subunits and stabilizes the binding of the initiator met-trna(i) to 40 s ribosomal subunits.
2173	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. srp9 together with srp14 and the alu portion of the srp rna, constitutes the elongation arrest domain of srp. the complex of srp9 and srp14 is required for srp rna binding.
2174	transcriptional regulator involved in developmental processes. can activate pomc gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.
2175	seems to phosphorylate critical substrates that regulate the g1/s phase transition and/or dna replication. can phosphorylates mcm2 and mcm3.
2176	
2177	
2178	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
2179	this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of sodium and potassium ions across the plasma membrane. this action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
2180	
2181	involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
2182	cross-linked envelope protein of keratinocytes. it is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. all that results in the formation of an insoluble envelope beneath the plasma membrane.
2183	
2184	
2185	
2186	recruited and tyrosine phosphorylated by several receptor systems, for example the t-cell, leptin and insulin receptors. once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to sh2 and sh3 domain- containing proteins. role in g2-m progression in the cell cycle. represses cbp-dependent transcriptional activation apparently by competing with other nuclear factors for binding to cbp. also acts as a putative regulator of mrna stability and/or translation rates and mediates mrna nuclear export. isoform 3 is only expressed in growth-arrested cells and inhibits s phase entry.
2187	might be involved in angiogenesis inhibition.
2188	
2189	receptor for glutamate. l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists. this receptor binds domoate > kainate >> l-glutamate = quisqualate >> ampa = nmda.
2190	essential subunit of n-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide to an asparagine residue within an asn-x-ser/thr consensus motif in nascent polypeptide chains.
2191	
2192	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. the alpha and alpha@#$%& chains contain the catalytic site. participates in wnt signaling. ck2 phosphorylates ser-392 of p53/tp53 following uv irradiation.
2193	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
2194	
2195	responsible for the synthesis of complex-type n-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. can produce lactose.
2196	
2197	
2198	
2199	
2200	
2201	
2202	catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (srebps). other known substrates are bdnf and atf6.
2203	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. component of the iron-sulfur (ip) fragment of the enzyme.
2204	catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (srebps). other known substrates are bdnf and atf6.
2205	
2206	ga733 tumor-associated antigen gene family may function as growth factor receptors.
2207	
2208	
2209	this protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. form i catalyzes the n-oxygenation of secondary and tertiary amines.
2210	
2211	
2212	
2213	may play a role in the molecular organization of synapses and neuronal cell signaling. could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. may induce enrichment of psd-95/sap90 at the plasma membrane.
2214	
2215	collagen type iii occurs in most soft connective tissues along with type i collagen.
2216	
2217	potentially plays a role in the ras signal transduction pathway. capable of suppressing v-ras transformation in vitro.
2218	potentially plays a role in the ras signal transduction pathway. capable of suppressing v-ras transformation in vitro.
2219	the function of brain maps is essentially unknown. phosphorylated map1b may play a role in the cytoskeletal changes that accompany neurite extension. possibly map1b binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules.
2220	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
2221	
2222	
2223	catalyzes the conversion of cortisol to the inactive metabolite cortisone. modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
2224	transfers 1,4-n-acetylgalactosamine (galnac) from udp- galnac to the nonreducing end of glucuronic acid (glcua). required for addition of the first galnac to the core tetrasaccharide linker and for elongation of chondroitin chains.
2225	
2226	
2227	cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton.
2228	displays phosphatase activity toward several substrates. the highest relative activity is toward erk1.
2229	
2230	
2231	
2232	this is one of the five types (d1 to d5) of receptors for dopamine. the activity of this receptor is mediated by g proteins which inhibit adenylyl cyclase.
2233	
2234	
2235	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
2236	
2237	
2238	3@#$%&-to-5@#$%& exoribonuclease specific for small oligoribonucleotides. active on small (primarily </=5 nucleotides in length) single-stranded rna and dna oligomers. may have a role for cellular nucleotide recycling.
2239	mediates homophilic cell-cell adhesion.
2240	
2241	
2242	
2243	
2244	
2245	involved in the wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with frizzled for wnt.
2246	
2247	shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
2248	may bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. may be under transcriptional regulation of steroid hormones.
2249	binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (pcb) and weakly progesterone, potent inhibitor of phospholipase a2.
2250	
2251	the insulin-like growth factors possess growth-promoting activity. in vitro, they are potent mitogens for cultured cells. igf-ii is influenced by placental lactogen and may play a role in fetal development.
2252	
2253	
2254	
2255	
2256	
2257	mediates the na(+)-independent transport of organic anions such as taurocholate, the prostaglandins pgd2, pge1, pge2, leukotriene c4, thromboxane b2 and iloprost (by similarity).
2258	
2259	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
2260	
2261	
2262	
2263	
2264	
2265	forms calcium-sensitive (by similarity) chloride channels. may conduct other physiologically significant anions such as bicarbonate (by similarity).
2266	
2267	
2268	plays a role as a receptor for the recognition of mhc class i hla-e molecules by nk cells and some cytotoxic t-cells.
2269	prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
2270	regulates the gdp/gtp exchange reaction of the rho proteins by inhibiting the dissociation of gdp from them, and the subsequent binding of gtp to them.
2271	
2272	
2273	acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (by similarity). functions as an estrogen receptor (er)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. competes with ncoa1 for modulation of er transcriptional activity. probably involved in regulating mitochondrial respiration activity and in aging.
2274	unknown.
2275	
2276	
2277	
2278	
2279	
2280	produced by lymphocytes activated by specific antigens or mitogens. ifn-gamma, in addition to having antiviral activity, has important immunoregulatory functions. it is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type i interferons.
2281	specifically binds to domain c of the tax-responsive enhancer element in the long terminal repeat of htlv-i.
2282	may act as a tumor suppressor.
2283	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
2284	in the intracellular compartments, may function as a channel or small molecule transporter.
2285	
2286	
2287	probable transcription factor.
2288	
2289	probable e3 ubiquitin ligase protein, which mediates ubiquitination and subsequent proteasomal degradation of target proteins. may function as a facilitator or regulator of transcriptional activation by myc. may have a role during synaptogenesis.
2290	may play a role in lymphocyte activation.
2291	
2292	
2293	
2294	
2295	
2296	
2297	implicated in immunoproteasome assembly and required for efficient antigen processing. the pa28 activator complex enhances the generation of class i binding peptides by altering the cleavage pattern of the proteasome.
2298	implicated in immunoproteasome assembly and required for efficient antigen processing. the pa28 activator complex enhances the generation of class i binding peptides by altering the cleavage pattern of the proteasome.
2299	repairs oxidative dna damages in vitro. may have a role in protection against cell lethality and suppression of mutations. removes the blocking groups from the 3@#$%& termini of the dna strand breaks generated by ionizing radiations and bleomycin.
2300	
2301	
2302	
2303	promotes adhesion of endothelial cells through interaction of integrins and the rgd motif. could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling.
2304	
2305	may function as a phosphatase involved in the regulation of cell growth and differentiation.
2306	converts d-glucuronic acid residues adjacent to n- sulfate sugar residues to l-iduronic acids (by similarity).
2307	probably plays a role in cartilage scaffolding. may act by antagonizing tgf-beta1 (tgfb1) and igf1 functions. has the ability to suppress igf1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced igf1r autophosphorylation. may inhibit tgfb1-mediated induction of cartilage matrix genes via its interaction with tgfb1. overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (ppi) supersaturation in aging and osteoarthritis cartilage.
2308	may control phosphatidylinositol concentration in transport vesicles from the subrhabdomeric cisternae (src) to the rhabdomere. may function as a calcium transporter.
2309	likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the rx(k/r)r consensus motif.
2310	
2311	
2312	
2313	retards apoptosis induced by il-3 deprivation. may function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (by similarity).
2314	
2315	
2316	
2317	
2318	
2319	
2320	major role in the synthesis of nucleoside triphosphates other than atp. the atp gamma phosphate is transferred to the ndp beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
2321	
2322	serum albumin, the main protein of plasma, has a good binding capacity for water, ca(2+), na(+), k(+), fatty acids, hormones, bilirubin and drugs. its main function is the regulation of the colloidal osmotic pressure of blood.
2323	
2324	part of pre- and post-splicing multiprotein mrnp complexes. enhances the formation of the atp-dependent a complex of the spliceosome. involved in both constitutive splicing and, in association with srp54 and sfrs10, in distinctive modulation of alternative splicing in a substrate-dependent manner. participates in mrna 3@#$%&end cleavage. involved in rent2-dependent nonsense- mediated decay (nmd) of mrnas containing premature stop codons. also mediates increase of mrna abundance and translational efficiency. binds spliced mrna 20-25 nt upstream of exon-exon junctions.
2325	
2326	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
2327	potential central metabolic regulator.
2328	
2329	
2330	
2331	ca(2+)-dependent modulation of synaptic efficacy.
2332	
2333	
2334	
2335	histone h3, along with histone h4, plays a central role in nucleosome formation.
2336	protease with a carboxypeptidase b-like function involved in killer toxin and alpha-factor precursor processing.
2337	
2338	
2339	
2340	
2341	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2). icam2 may play a role in lymphocyte recirculation by blocking lfa-1-dependent cell adhesion. it mediates adhesive interactions important for antigen- specific immune response, nk-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
2342	exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper b into subunit i (by similarity).
2343	
2344	
2345	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
2346	acts as a transcriptional activator of the c-myc gene; binds dna nonspecifically (ref.3).
2347	type i collagen is a member of group i collagen (fibrillar forming collagen).
2348	chemoattractant for blood monocytes, memory t-helper cells and eosinophils. causes the release of histamine from basophils and activates eosinophils. binds to ccr1, ccr3, ccr4 and ccr5. one of the major hiv-suppressive factors produced by cd8+ t- cells. recombinant rantes protein induces a dose-dependent inhibition of different strains of hiv-1, hiv-2, and simian immunodeficiency virus (siv). the processed form rantes(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of hiv-1-infection. the second processed form rantes(4-68) exhibits reduced chemotactic and hiv-suppressive activity compared with rantes(1-68) and rantes(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.
2349	
2350	
2351	protein transport. probably involved in vesicular traffic (by similarity).
2352	essential component of nuclear pore complex.
2353	
2354	
2355	
2356	splice factor that is required for the first atp- dependent step in spliceosome assembly and for the interaction of u2 snrnp with the branchpoint. has weak rna-dependent atpase activity. required for mrna export.
2357	
2358	terminates the action of serotonine by its high affinity sodium-dependent reuptake into presynaptic terminals.
2359	
2360	essential for the degradation of glygogen to glucose in lysosomes.
2361	seems to play a negative regulatory role in prpp synthesis.
2362	
2363	can activate specifically hydrolysis of gtp bound to rac1 and cdc42, but not rala. mediates atp-dependent transport of s-(2,4-dinitrophenyl)-glutathione (dnp-sg) and doxorubicin (dox) and is the major atp-dependent transporter of glutathione conjugates of electrophiles (gs-e) and dox in erythrocytes. can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon.
2364	
2365	
2366	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
2367	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
2368	inhibits urokinase-type plasminogen activator. the monocyte derived pai-2 is distinct from the endothelial cell- derived pai-1.
2369	
2370	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
2371	
2372	
2373	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2).
2374	catalyzes electron transfer from reduced pyridine nucleotides to flavins as well as methylene blue, pyrroloquinoline quinone, riboflavin, or methemoglobin. possible role in protecting cells from oxidative damage or in regulating iron metabolism. in the liver, converts biliverdin to bilirubin.
2375	
2376	
2377	this receptor has essential roles in the regulation of ige production and in the differentiation of b-cells (it is a b- cell-specific antigen).
2378	
2379	
2380	may be involved in desquamation.
2381	stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. acts synergistically with other cytokines, including il-3, gcsf, gmcsf and flt3 ligand. suppresses scf-stimulated erythrocyte proliferation.
2382	
2383	nmda receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine.
2384	
2385	
2386	component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to atp synthesis.
2387	required for fusion of er-derived vesicles with the golgi during er-to-golgi protein transport. may be involved in proper membrane localization of rab gtpases.
2388	
2389	transcriptional corepressor that binds to a number of transcription factors. inhibits the transcriptional activation mediated by ctnnb1 and tcf family members in wnt signaling. the effects of full-length tle family members may be modulated by association with dominant-negative aes (by similarity).
2390	
2391	
2392	
2393	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
2394	p65 is a subunit of the nuclear factor kappa-b, a second messenger, which activates the transcription of a number of genes in multiple tissues. the inhibitory effect of i-kappa-b upon nf- kappa-b in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak dna-binding site which could contribute directly to dna binding in the nf-kappa-b complex.
2395	transcription factor that binds to a symmetrical dna sequence (e-boxes) (5@#$%&-cacgtg-3@#$%&) that is found in a variety of viral and cellular promoters.
2396	isomerization of 3-trans,5-cis-dienoyl-coa to 2-trans,4- trans-dienoyl-coa (by similarity).
2397	transcriptional repressor.
2398	hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate.
2399	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
2400	
2401	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. receptor for activin a, activin b and inhibin a.
2402	
2403	
2404	
2405	
2406	inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. inhibins appear to oppose the functions of activins.
2407	enzyme which catalyzes the acetylation of polyamines. substrate specificity: norspermidine = spermidine >> spermine > n(1)acetylspermine > putrescine. this highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. also involved in the regulation of polyamine transport out of cells (by similarity).
2408	la protein plays a role in the transcription of rna polymerase iii. it is most probably a transcription termination factor. binds to the 3@#$%& termini of virtually all nascent polymerase iii transcripts. it is associated with precursor forms of rna polymerase iii transcripts including trna and 4.5s, 5s, 7s, and 7-2 rnas.
2409	
2410	
2411	
2412	chaperone necessary for the assembly of mitochondrial respiratory chain complex iii.
2413	the intermediate chains seem to help dynein bind to dynactin 150 kda component.
2414	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
2415	
2416	
2417	component of the 60-80s u3 small nucleolar ribonucleoprotein (u3 snornp). required for the early cleavages during pre-18s ribosomal rna processing.
2418	
2419	may be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. augments cytokine-mediated stat transcription. enhances cbp/p300 coactivator protein recruitment to stat1 and stat5.
2420	
2421	
2422	protein transport. regulator of membrane traffic from the golgi apparatus towards the endoplasmic reticulum (er). has a low gtpase activity.
2423	acts as a regulator of traf function by maintaining them in a latent state. overexpression inhibits traf2-mediated nf- kappa-b activation signaled by cd40, tnfr1 and tnfr2. blocks traf2 binding to lmp1 and inhibits lmp1-mediated nf-kappa-b activation.
2424	
2425	
2426	straight-chain enoyl-coa thioesters from c4 up to at least c16 are processed, although with decreasing catalytic rate.
2427	straight-chain enoyl-coa thioesters from c4 up to at least c16 are processed, although with decreasing catalytic rate.
2428	
2429	acts as a positive regulator of apoptosis.
2430	
2431	required for 60s ribosomal subunit biogenesis (by similarity).
2432	
2433	
2434	
2435	may play a role in the recruitment of beta-1 integrins to the focal contacts during integrin-dependent cell adhesion. isoform 2 does not bind the integrin cytoplasmic domain-associated protein-1.
2436	involved in pre-mrna splicing.
2437	
2438	may be involved in several stages of intracellular trafficking (by similarity).
2439	
2440	thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of cox.
2441	associated with snrnp u1, u2, u4/u6 and u5. may have a functional role in the pre-mrna splicing or in snrnp structure.
2442	
2443	has 2-hydroxyacid oxidase activity. most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids.
2444	may be involved in transcriptional regulation as a repressor.
2445	
2446	
2447	
2448	may function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
2449	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex. f6 seems to be part of the stalk that links cf(0) to cf(1). also involved in the restoration of oligomycin-sensitive atpase activity to depleted f1-f0 complexes.
2450	destroys radicals which are normally produced within the cells and which are toxic to biological systems.
2451	
2452	
2453	
2454	this is an intracellular thiol proteinase inhibitor. tightly binding reversible inhibitor of cathepsins l, h and b.
2455	promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, aes and tle1.
2456	could have a part in mechanisms of transcriptional regulation similar to that played by yeast hir1 and hir2 together.
2457	type i collagen is a member of group i collagen (fibrillar forming collagen).
2458	may function as a transcription factor.
2459	
2460	
2461	
2462	
2463	promotes guanine-nucleotide exchange on arf1 and arf5. promotes the activation of arf through replacement of gdp with gtp.
2464	
2465	rna-dependent atpase activity. the rate of atp hydrolysis is highly stimulated by single-stranded rna.
2466	
2467	
2468	
2469	
2470	thiol protease. has dipeptidylpeptidase activity. can act as both an exopeptidase and endopeptidase. activates serine proteases such as elastase, cathepsin g and granzymes a and b. can also activate neuraminidase and factor xiii.
2471	may play a role in the regulation of pre-mrna splicing.
2472	transcriptional repressor that play an important role in the specification and differentiation of lung epithelium.
2473	
2474	this protein promotes the gtp-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome.
2475	seems to act exclusively upon threonine residues (by similarity).
2476	involved in mediating u snrna export from the nucleus. binds to 5@#$%& capped mrna.
2477	implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. may be involved in the regulation of perinuclear intravesicular membrane traffic (by similarity).
2478	
2479	favors the reduction of estrogens and androgens. also has 20-alpha-hsd activity. uses preferentially nadh.
2480	
2481	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
2482	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
2483	
2484	involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. it n-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. acts on tma to produce tma-n-oxide.
2485	
2486	strong inhibitor of acrosin in male and/or female genital tract. also inhibits trypsin.
2487	
2488	chemotactic for neutrophil granulocytes.
2489	binds preferentially single-stranded dna and unwinds double stranded dna.
2490	
2491	probably catalyzes the first step in biosynthesis of glycosaminoglycan. transfers d-xylose from udp-d-xylose to specific serine residues of the core protein. initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (by similarity). its enzyme activity has not been demonstrated.
2492	may act as a gtpase activating protein for rab family protein(s).
2493	may act as a gtpase activating protein for rab family protein(s).
2494	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
2495	
2496	receptor for steroids (potential).
2497	may play a role in cell proliferation.
2498	
2499	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
2500	
2501	encodes an essential ribose methyltransferase that specifically modifies to 2@#$%&-o-methylguanosine a universally conserved nucleotide, g-2270, in the peptidyl transferase center of the mitochondrial large ribosomal rna (21s). this modification seems to be important for the normal accumulation of this latter 21s subunit.
2502	beta-hexosaminidase a is responsible for the degradation of gm2 gangliosides, and a variety of other molecules containing terminal n-acetyl hexosamines, in the brain and other tissues.
2503	isoform 2 up-regulates the production of ghbp and acts as a negative inhibitor of gh signaling.
2504	functions in nuclear protein import as nuclear transport receptor. serves as receptor for nuclear localization signals (nls) in cargo substrates. is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (npc) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus (by similarity). involved in nuclear import of m9- containing proteins. in vitro, binds directly to the m9 region of the heterogeneous nuclear ribonucleoproteins (hnrnp), a1 and a2 and mediates their nuclear import. appears also to be involved in hnrnp a1/a2 nuclear export. mediates the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones, and srp19.
2505	
2506	
2507	
2508	
2509	may behave as an activator of the bound transcription factor, mybl2, and be involved in embryonic development.
2510	
2511	
2512	drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively. binds f-actin.
2513	
2514	
2515	does not seem to have ndk kinase activity. confers protection from cell death by bax and alters the cellular levels of several antioxidant enzymes including gpx5. may play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (by similarity).
2516	
2517	atp-dependent rna helicase involved nonsense-mediated mrna decay and ribosome biogenesis through rrna processing.
2518	transcriptional activator; dna-binding protein that specifically recognize the sequence 5@#$%&-yaac[gt]g-3@#$%&. plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
2519	dna-binding protein involved in cell cycle control. may act as a transcription activator. also seems to be involved in the second catalytic step of pre-mrna splicing.
2520	
2521	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
2522	
2523	
2524	factor b which is part of the alternate pathway of the complement system is cleaved by factor d into 2 fragments: ba and bb. bb, a serine protease, then combines with complement factor 3b to generate the c3 or c5 convertase.
2525	
2526	appears to mediate interactions between cells and the extracellular matrix. substrate-adhesion molecule that appears to inhibit cell migration. may play a role in supporting the growth of epithelial tumors.
2527	
2528	
2529	snare that acts to regulate protein transport between late endosomes and the trans-golgi network.
2530	
2531	
2532	
2533	
2534	positive modulator of atm response to dna damage.
2535	able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-coa species.
2536	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form.
2537	has a broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. can hydrolyze nucleoside 5@#$%& triphosphates such as atp, gtp, ctp, ttp and utp to their corresponding monophosphates with release of pyrophosphate. can hydrolyze diadenosine polyphosphates and 3@#$%&,5@#$%&-camp to amp. it may play a role in the regulation of pyrophosphate production, the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and golgi, and the regulation of purinergic signaling.
2538	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
2539	
2540	transport of phosphorylated lysosomal enzymes from the golgi complex and the cell surface to lysosomes. lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low ph mediates the dissociation of the complex. this receptor also binds igf2.
2541	
2542	
2543	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
2544	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. may catalyze basal processing of intracellular antigens.
2545	
2546	
2547	ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. in vitro, also has barbed end capping and nucleating activities in the presence of ca(2+).
2548	
2549	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
2550	
2551	
2552	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
2553	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
2554	
2555	
2556	
2557	collagen type iii occurs in most soft connective tissues along with type i collagen.
2558	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
2559	
2560	
2561	
2562	
2563	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
2564	
2565	may be involved in transcriptional regulation.
2566	inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme.
2567	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
2568	may play a role in reproduction.
2569	
2570	calcium-dependent, calmodulin-stimulated protein phosphatase. this subunit may have a role in the calmodulin activation of calcineurin.
2571	
2572	this is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
2573	
2574	seems to function as an adapter protein. in adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. seems to couple transcription factor sox4 to the il-5 receptor (il5ra). may also play a role in vesicular trafficking. seems to be required for the targeting of tgfa to the cell surface in the early secretory pathway.
2575	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
2576	
2577	
2578	has antibacterial activity (potential).
2579	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
2580	
2581	
2582	guanine nucleotide exchange factor (gef) for rab-3 and cab-1. novel regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release. is also a regulator of the cab-1 synaptic transmission pathway.
2583	
2584	reversible hydration of carbon dioxide. may be involved in the control of cell proliferation and transformation. appears to be a novel specific biomarker for a cervical neoplasia.
2585	
2586	functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-pge1, 15-oxo-pge2 and 15-oxo-pge2alpha. has no activity towards pge1, pge2 and pge2alpha (by similarity). catalyzes the conversion of leukotriene b4 into its biologically less active metabolite, 12-oxo-leukotriene b4. this is an initial and key step of metabolic inactivation of leukotriene b4.
2587	
2588	
2589	sam (substrate-adhesion molecule) that appears to inhibit cell migration. may play a role in supporting the growth of epithelial tumors. is a ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-v/beta-3 and alpha-v/beta-6.
2590	involved in serum exerting lectin activity. binds glcnac.
2591	
2592	
2593	
2594	involved in the maturation of asn-linked oligosaccharides. trim a single alpha-1,2-linked mannose residue from man(9)glcnac(2) to produce man(8)glcnac(2). the only product is the man(8)glcnac(2) isomer b, the form lacking the middle-arm terminal alpha 1,2-mannose. it may be involved in glycoprotein quality control since it is important to target misfolded glycoproteins for degradation.
2595	forms a channel for water and glycerol.
2596	collagen type iv is specific for basement membranes.
2597	molecular chaperone; assists the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
2598	implicated in the control of cell fate decisions during development.
2599	putative function in synaptic vesicle exocytosis by binding to stxbp1, an essential component of the synaptic vesicle exocytotic machinery. may modulate processing of the beta-amyloid precursor protein (app) and hence formation of beta-app.
2600	interconversion of serine and glycine.
2601	reduces the number of supercoils in a highly negatively supercoiled dna.
2602	tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. it seems to be required for cartilage and growth plate development.
2603	
2604	atp-dependent 5@#$%&-3@#$%& dna helicase, component of the core- tfiih basal transcription factor. involved in nucleotide excision repair (ner) of dna by opening dna around the damage, and in rna transcription by rna polymerase ii by anchoring the cdk-activating kinase (cak) complex, composed of cdk7, cyclin h and mat1, to the core-tfiih complex. might also have a role in aging process and could play a causative role in the generation of skin cancers.
2605	binds to an err-alpha response element (erre) containing a single consensus half-site, 5@#$%&-tnaaggtca-3@#$%&. can bind to the medium-chain acyl coenzyme a dehydrogenase (mcad) response element nrre-1 and may act as an important regulator of mcad promoter. binds to the c1 region of the lactoferrin gene promoter.
2606	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
2607	
2608	regulatory subunit of the calcium activated potassium kcnma1 (maxik) channel. modulates the calcium sensitivity and gating kinetics of kcnma1, thereby contributing to kcnma1 channel diversity. acts as a negative regulator that confers rapid and complete inactivation of kcnma1 channel complex. may participate in kcnma1 inactivation in chromaffin cells of the adrenal gland or in hippocampal ca1 neurons.
2609	
2610	
2611	
2612	
2613	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
2614	regulates beta-adrenergic receptor function. beta- arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate g(s) proteins.
2615	
2616	may be involved in transcriptional regulation.
2617	
2618	
2619	
2620	may facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery.
2621	
2622	may be required for polarization of epithelia (by similarity).
2623	
2624	
2625	
2626	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
2627	
2628	gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. it also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
2629	
2630	may play a key role in signal transduction and growth control.
2631	rna and ssdna-binding protein that may play specific roles during transcription initiation at distinct promoters. can enter the preinitiation complex together with the rna polymerase ii (pol ii).
2632	involved in stabilization of lens fiber cell cytoskeleton (by similarity).
2633	calcium-dependent and glcnac-binding lectin. enhanced phagocytosis of s.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region (by similarity).
2634	identifies cytotoxic/suppressor t-cells that interact with mhc class i bearing targets. cd8 is thought to play a role in the process of t-cell mediated killing.
2635	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.
2636	required for dna replication. plays a role in the rescue of stalled replication forks and checkpoint control. binds double- stranded dna breaks and nicks as well as single-stranded dna. recruits the swi/snf chromatin remodeling complex to e2f1- responsive promoters. down-regulates e2f1 activity and inhibits e2f1-dependent apoptosis during g1/s transition and after dna damage. induces a large increase in the kinase activity of atr.
2637	growth factor for endothelial cells. vegf-b167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of vegf-b186 is regulated by proteolysis.
2638	cross-linked envelope protein of keratinocytes. it is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. all that results in the formation of an insoluble envelope beneath the plasma membrane. can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage.
2639	common mediator of signal transduction by tgf-beta (transforming growth factor) superfamily; smad4 is the common smad (co-smad). promotes binding of the smad2/smad4/fast-1 complex to dna and provides an activation function required for smad1 or smad2 to stimulate transcription. may act as a tumor suppressor.
2640	
2641	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
2642	
2643	phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin i. the alpha chain may bind calmodulin.
2644	
2645	
2646	
2647	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
2648	
2649	involved in the apoptotic response after nerve growth factor (ngf) binding in neuronal cells. binds p75ntr and antagonizes its association with trka, inhibits cell cycle progression, and facilitates p75ntr-mediated apoptosis. may act as a regulator of the function of dlx family members (by similarity).
2650	inhibitory effect on stress fiber organization. may down-regulate rho-like gtpase in hematopoietic cells.
2651	required for the uptake of creatine in muscles and brain.
2652	putative adhesion molecule that mediates sialic-acid dependent binding to cells. binds equally to alpha2,3-linked and alpha2,6-linked sialic acid. the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
2653	
2654	
2655	
2656	
2657	inhibits the transcription of ribosomal rna. may inhibits the specific dna binding of ubf1.
2658	
2659	cytochalasin b-sensitive carrier. seems to function primarily as a fructose transporter.
2660	this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of sodium and potassium ions across the plasma membrane. this action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
2661	necessary for early peroxisomal biogenesis. acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (pmps). binds and stabilizes newly synthesized pmps in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein pex3. excludes cdkn2a from the nucleus and prevents its interaction with mdm2, which results in active degradation of tp53.
2662	probably involved in the organization of the actin cytoskeleton. may act downstream of cdc42 to induce actin filament assembly leading to cell shape changes. induces pseudopodia formation in fibroblasts in a cdc42-dependent manner.
2663	
2664	
2665	isoform f play a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.
2666	the numerous interruptions in the triple helix may make this molecule either elastic or flexible.
2667	igf-1 leads to the activation of akt3, which may play a role in regulating cell survival. capable of phosphorylating several known proteins. truncated isoform 2/pkb gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
2668	protein 4.1 is a major structural element of the erythrocyte membrane skeleton. it plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. recruits dlg1 to membranes.
2669	plays a role in transcriptional coactivation.
2670	
2671	
2672	
2673	converts udp and glcnac-1-p into udp-glcnac, and udp and galnac-1-p into udp-galnac. isoform agx1 has 2 to 3 times higher activity towards galnac-1-p, while isoform agx2 has 8 times more activity towards glcnac-1-p.
2674	high-affinity transporter for the intake of thiamine.
2675	could be involved in the induction of mineralization of extracellular matrix.
2676	
2677	
2678	
2679	
2680	
2681	this proteoglycan is a major component of extracellular matrix of cartilagenous tissues. a major function of this protein is to resist compression in cartilage. it binds avidly to hyaluronic acid via an n-terminal globular region.
2682	tyrosine kinase that plays an essential role for the selection and maturation of developing t-cell in the thymus and in mature t-cell function. is constitutively associated with the cytoplasmic portions of the cd4 and cd8 surface receptors and plays a key role in t-cell antigen receptor(tcr)-linked signal transduction pathways. association of the tcr with a peptide antigen-bound mhc complex facilitates the interaction of cd4 and cd8 with mhc class ii and class i molecules, respectively, and thereby recruits the associated lck to the vicinity of the tcr/cd3 complex. lck then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (itams) in the cytoplasmic tails of the tcrgamma chains and cd3 subunits, initiating the tcr/cd3 signaling pathway. in addition, contributes to signaling by other receptor molecules. associates directly with the cytoplasmic tail of cd2, and upon engagement of the cd2 molecule, lck undergoes hyperphosphorylation and activation. also plays a role in the il2 receptor-linked signaling pathway that controls t-cell proliferative response. binding of il2 to its receptor results in increased activity of lck. is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-tcr and mature alpha beta tcr.
2683	molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin. plays a role in the assembly of the von hippel- lindau ubiquitination complex.
2684	
2685	
2686	
2687	subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-golgi network (tgn) to the endosomal-lysosomal system.
2688	required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier. functions as a homophilic cell-adhesion molecule. may play a role in early neuronal differentiation and axon outgrowth.
2689	inactivates paf by removing the acetyl group at the sn-2 position. this is a catalytic subunit. plays an important role during the development of brain.
2690	component of the peroxisomal translocation machinery with pex13 and pex17. interacts with both the pts1 and pts2 receptors. binds directly to pex17.
2691	required for normal golgi morphology and function.
2692	binds to pre-mrna. has high affinity for scaffold- attached region (sar) dna. bind to double- and single-stranded dna and rna.
2693	
2694	
2695	implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2a, regulation of mrna trafficking and stability in association with elavl1, and inhibition of acetyltransferases as part of the inhat (inhibitor of histone acetyltransferases) complex (by similarity).
2696	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. ladsin exerts cell- scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.
2697	may modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release by potentiating the interaction of synaptotagmins with the snares and the plasma- membrane-associated protein snap25. its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. may also have a role in the mechanisms of snare-mediated membrane fusion in non-neuronal cells (by similarity).
2698	cd2 interacts with lymphocyte function-associated antigen (lfa-3) and cd48/bcm1 to mediate adhesion between t-cells and other cell types. cd2 is implicated in the triggering of t- cells, the cytoplasmic domain is implicated in the signaling function.
2699	
2700	vimentins are class-iii intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.
2701	vimentins are class-iii intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.
2702	promotes guanine-nucleotide exchange on arf5. promotes the activation of arf5 through replacement of gdp with gtp (by similarity).
2703	
2704	may participate in diverse steps of neurogenesis. binds calcium.
2705	
2706	
2707	
2708	
2709	transcriptional repressor. mxi1 binds with max to form a sequence-specific dna-binding protein complex which recognizes the core sequence 5@#$%&-cac[ga]tg-3@#$%&. mxi1 thus antagonizes myc transcriptional activity by competing for max.
2710	
2711	attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to na-k atpase, to the lymphocyte membrane protein gp85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. in skeletal muscle, isoform mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
2712	tfiif is a general transcription initiation factor that binds to rna polymerase ii and helps to recruit it to the initiation complex in collaboration with tfiib. it promotes transcription elongation.
2713	
2714	regulates the gdp/gtp exchange reaction of most rab proteins by inhibiting the dissociation of gdp from them, and the subsequent binding of gtp to them.
2715	rna-binding protein. possesses nucleolytic activity against cytotoxic lymphocyte target cells. may be involved in apoptosis.
2716	
2717	may be involved in melanosomal transport and docking. involved in the proper sorting of tyrp1.
2718	binds to the dendritic targeting element and may play a role in mrna trafficking (by similarity). part of a ternary complex that binds to the downstream control sequence (dcs) of the pre-mrna. mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. may interact with single- stranded dna from the far-upstream element (fuse). may activate gene expression. also involved in degradation of inherently unstable mrnas that contain au-rich elements (ares) in their 3@#$%& untranslated regions, possibly by recruiting degradation machinery to are-containing mrnas.
2719	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
2720	
2721	pyruvate carboxylase catalyzes a 2-step reaction, involving the atp-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
2722	can degrade fibronectin, laminin, gelatins of type i, iii, iv, and v; collagens iii, iv, x, and ix, and cartilage proteoglycans. activates procollagenase.
2723	
2724	
2725	
2726	
2727	
2728	
2729	
2730	
2731	
2732	
2733	
2734	
2735	plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. could be an adhesion molecule active in neural crest cells during embryonic development. acts as surface receptor that triggers tyrosine phosphorylation of fyn and ptk2, and a transient increase in the intracellular calcium concentration.
2736	
2737	prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (er). binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (srp), which normally targets nascent secretory peptides to the er. also reduces the inherent affinity of ribosomes for protein translocation sites in the er membrane (m sites). may act as a specific coactivator for jun, binding to dna and stabilizing the interaction of jun homodimers with target gene promoters.
2738	
2739	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
2740	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity).
2741	
2742	required only in the female germ line. it is important for oocyte formation and in the specification of the posterior structures of the embryo.
2743	may be involved in regulation of synaptic vesicle endocytosis. may act as a tumor suppressor and inhibits malignant cell transformation.
2744	
2745	plays a key role in hematopoiesis. this ptpase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. the sh2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates.
2746	glandular kallikreins cleave met-lys and arg-ser bonds in kininogen to release lys-bradykinin.
2747	
2748	
2749	
2750	nuclear hormone receptor. vdr mediates the action of vitamin d3 by controlling the expression of hormone sensitive genes.
2751	
2752	thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. in vitro it binds mhc, f-actin and native thin filaments, and modifies the activity of actin-activated myosin atpase. it may modulate muscle contraction or may play a more structural role.
2753	
2754	
2755	specifically removes c-terminal basic residues (arg or lys) from peptides and proteins. it is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.
2756	required for the binding of mrna to ribosomes. functions in close association with eif4-f and eif4-a. binds near the 5@#$%&- terminal cap of mrna in presence of eif-4f and atp. promotes the atpase activity and the atp-dependent rna unwinding activity of both eif4-a and eif4-f.
2757	binds to gtp-bound form of rho and to profilin. acts in a rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. it is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics (by similarity).
2758	
2759	transcriptional repressor. acts on the c-type natriuretic peptide (cnp) promoter.
2760	
2761	
2762	
2763	may play a role in ubiquitination and subsequent proteosomal degradation of target proteins.
2764	
2765	presents carbohydrate ligands to selectins. also implicated in tumor cell metastasis.
2766	molecular chaperone. has atpase activity (by similarity).
2767	molecular chaperone. has atpase activity (by similarity).
2768	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
2769	although its physiological function is unclear, it can inhibit neutrophil cathepsin g and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
2770	binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to tram (translocating chain-associating membrane protein).
2771	binds pre-mrna and nucleates the assembly of 40s hnrnp particles. single hnrpc tetramers bind 230-240 nucleotides. trimers of hnrpc tetramers bind 700 nucleotides. may play a role in the early steps of spliceosome assembly and pre-mrna splicing. interacts with poly-u tracts in the 3@#$%& or 5@#$%& untranslated regions of mrna and modulates the stability and the level of translation of bound mrna molecules.
2772	involved in the base excision repair (ber) pathway, by catalyzing the poly(adp-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in dna metabolism. this modification follows dna damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of dna strand breaks.
2773	
2774	involved in neurogenesis.
2775	cell adhesion glycoprotein which is widely distributed in basement membranes. binds to collagens i and iv, to perlecan and to laminin 1. does not bind fibulins. it probably has a role in cell-extracellular matrix interactions.
2776	
2777	its physiological role is not yet clear.
2778	receptor for extracellular atp > utp and adp. the activity of this receptor is mediated by g proteins which activate a phosphatidylinositol-calcium second messenger system. may be the cardiac p2y receptor involved in the regulation of cardiac muscle contraction through modulation of l-type calcium currents. is a receptor for leukotriene b4, a potent chemoattractant involved in inflammation and immune response.
2779	
2780	
2781	
2782	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
2783	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
2784	
2785	
2786	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
2787	carries 11-cis-retinol and 11-cis-retinaldehyde as endogenous ligands and may be a functional component of the visual cycle.
2788	
2789	
2790	
2791	
2792	probable component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. can interact with bub3, cenp-f, cenp-e and mitosin.
2793	
2794	critical component of the membrane-bound oxidase of phagocytes that generates superoxide. associates with nox3 to form a functional nadph oxidase constitutively generating superoxide.
2795	component of the transcription factor sl1/tifib complex involved in the assembly of the pic (preinitiation complex). recruits rna polymerase i to the rrna gene promoter via interaction with rrn3.
2796	
2797	
2798	may be involved in transcriptional regulation.
2799	required for protein transport from the er to the golgi complex.
2800	able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-coa species.
2801	
2802	
2803	in addition to gelatin and collagens, it cleaves kiss1 at a gly-|-leu bond.
2804	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
2805	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
2806	acetyltransferase enzyme. acetylates histones, giving a specific tag for transcriptional activation. also acetylates non- histone proteins, like ncoa3 coactivator. mediates camp-gene regulation by binding specifically to phosphorylated creb protein. cbp, as coactivator, augments the activity of phosphorylated creb to activate transcription of camp-responsive genes.
2807	
2808	
2809	catalyzes three sequential methylation of phosphatidylethanolamine (pe) by adomet, thus producing phosphatidylcholine (pc).
2810	
2811	binds to the 5@#$%&-aacaat-3@#$%& sequence.
2812	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (by similarity).
2813	involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion (by similarity).
2814	could be involved in calcium-dependent cell adhesion or intercellular interactions.
2815	
2816	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
2817	
2818	
2819	
2820	probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. its precise role is however unclear, since it does not bind to very low density lipoprotein (vldl) or to lrpap1 in vitro.
2821	anti-proliferative protein that interacts with the erbb- 2 receptor tyrosine kinase. may physically and/or functionally interact with protein-tyrosine kinase receptors.
2822	this protein is one of the chains of the nonenzymatic membrane component (f0) of mitochondrial atpase.
2823	may be involved in transcriptional regulation.
2824	involved in nucleolar processing of pre-18s ribosomal rna (by similarity).
2825	plays a major role in tight junction-specific obliteration of the intercellular space (by similarity).
2826	
2827	aminopeptidase with broad substrate specificity to several peptides. involved in proteolytic events essential for cell growth and viability. may act as regulator of neuropeptide activity (by similarity).
2828	involved in transcriptional activation and repression of select genes by chromatin remodelling (alteration of dna- nucleosome topology). required for the coactivation of estrogen responsive promoters by swi/snf complexes and the src/p160 family of histone acetyltransferases (hats). also specifically interacts with the corest corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.
2829	
2830	catalyzes the deacetylation of n-acetylaspartic acid (naa) to produce acetate and l-aspartate. naa occurs in high concentration in brain and its hydrolysis naa plays a significant part in the maintenance of intact white matter. in other tissues it act as a scavenger of naa from body fluids.
2831	involved in the transcriptional regulation of genes required for mesoderm differentiation. probably plays a role in limb pattern formation.
2832	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
2833	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
2834	promotes infectivity of neisseria gonorrhoeae in epithelial cells by phosphorylating mcp/cd46.
2835	collagen type iv is specific for basement membranes.
2836	3-phosphorylates the cellular phosphoinositide ptdins- 4,5-biphosphate (ptdins(4,5)p2) to produce ptdins-3, 4,5- triiphosphate (ptdins(3,4,5)p3). links g-protein coupled receptor activation to the secondary messenger ptdins(3,4,5)p3 production.
2837	adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. preferentially binds to alpha2,3- linked sialic acid (by similarity).
2838	may be involved in transcriptional regulation.
2839	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
2840	acts as a receptor for urokinase plasminogen activator. plays a role in localizing and promoting plasmin formation. mediates the proteolysis-independent signal transduction activation effects of u-pa. it is subject to negative-feedback regulation by u-pa which cleaves it into an inactive form.
2841	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2). icam3 is also a ligand for integrin alpha-d/beta-2.
2842	plays a role in transcriptional coactivation.
2843	
2844	
2845	endonuclease that specifically degrades the rna of rna- dna hybrids. participates in dna replication.
2846	may be a member of a yet unidentified signaling pathway and it may act as a tumor-suppressor.
2847	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
2848	
2849	receptor for the chemotactic and inflammatory peptide anaphylatoxin c5a, c4a and c3a and their desarginated derivatives. couples weakly to gi-mediated signaling pathways.
2850	
2851	serine/threonine kinase which acts as a positive regulator of apoptosis.
2852	
2853	
2854	
2855	may be involved in the activation of cells of innate and acquired immunity.
2856	
2857	binds a vh promoter proximal site necessary for induced mu-heavy-chain transcription. binds the minor groove of a restricted atc sequence that is sufficient for nuclear matrix association. this sequence motif is present in matrix-associating regions (mars) proximal to the promoter and flanking e mu. activates e mu-driven transcription by binding these sites (by similarity).
2858	activates transcription from class ii mhc promoters. activation requires the activity of the mhc class ii transactivator (mhc2ta). may regulate other genes in the cell. rfx binds the x1 box of mhc-ii promoters. isoform rfx-b-delta5 is not involved in the positive regulation of mhc class ii genes.
2859	
2860	
2861	
2862	
2863	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
2864	part of a post-splicing multiprotein complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity (by similarity).
2865	
2866	may act at junctions between the membrane and the cytoskeleton.
2867	may play a role in testis development (by similarity).
2868	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
2869	necessary for the splicing of pre-mrna. directly contacts the pre-mrna branch site adenosine for the first catalytic step of splicing. enters the spliceosome and associates with the pre-mrna branch site as part of the 17s u2 or, in the case of the minor spliceosome, as part of the 18s u11/u12 snrnp complex, and thus may facilitate the interaction of these snrnp with the branch sites of u2 and u12 respectively.
2870	plays a role in autophagy (by similarity).
2871	may be involved in assembly and membrane stacking of the golgi cisternae, and in the process by which golgi stacks reform after mitotic breakdown. may regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane tgfa.
2872	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
2873	
2874	
2875	possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
2876	
2877	
2878	sodium-phosphate symporter. active in early growth phase.
2879	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
2880	
2881	recognizes and binds the 7-methylguanosine-containing mrna cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mrnas secondary structures.
2882	
2883	
2884	
2885	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
2886	
2887	
2888	
2889	
2890	
2891	may be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. has cell adhesive capacity.
2892	
2893	
2894	
2895	required for correct chromosome alignement during metaphase. part of the mis12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis.
2896	
2897	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (by similarity).
2898	
2899	may be involved in transcriptional regulation.
2900	potential tumor suppressor. acts as a kras-specific effector protein. may promote apoptosis and cell cycle arrest.
2901	
2902	
2903	affects the rate of fibrils formation. may have a primary role in collagen fibrillogenesis (by similarity).
2904	
2905	pre-mrna binding protein in vivo, binds avidly to poly(g) and poly(u) rna homopolymers in vitro. involved in splicing. acts as a receptor for carcinoembryonic antigen in kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of il-1 alpha, il-6, il-10 and tumor necrosis factor alpha cytokines.
2906	
2907	
2908	involved in the maturation of asn-linked oligosaccharides. progressively trim alpha-1,2-linked mannose residues from man(9)glcnac(2) to produce man(5)glcnac(2).
2909	
2910	
2911	inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin a. could play a role during central nervous system development.
2912	
2913	ligand for the t-cell-specific cell surface receptor icos. acts as a costimulatory signal for t-cell proliferation and cytokine secretion; induces also b-cell proliferation and differentiation into plasma cells. could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory t-cell function (by similarity).
2914	
2915	
2916	essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. the ternary complex containing ufd1l, vcp and nploc4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the er to the cytoplasm, where they are degraded by the proteasome. the nploc4-ufd1l-vcp complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. it may be involved in the development of some ectoderm-derived structures.
2917	
2918	catalyzes the covalent attachment of ubiquitin to other proteins. mediates the selective degradation of short-lived and abnormal proteins. functions in the e6/e6-ap-induced ubiquitination of p53/tp53.
2919	
2920	associates with the ig-mu chain to form a molecular complex that is expressed on the surface of pre-b-cells.
2921	
2922	growth regulator. inhibits the proliferation of a number of tumor cell lines. it regulates cytokine production, including il-6, g-csf and gm-csf from endothelial cells.
2923	
2924	
2925	may regulate cell apoptosis and cell differentiation. binds beta-galactoside. binds cd45, cd3 and cd4. inhibits cd45 protein phosphatase activity and therefore the dephosphorylation of lyn kinase.
2926	furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the rx(k/r)r consensus motif.
2927	
2928	
2929	
2930	
2931	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
2932	
2933	integrin alpha-v/beta-5 is a receptor for fibronectin. it recognizes the sequence r-g-d in its ligand.
2934	regulates intracellular concentrations of taurine and glutamate. negatively modulates slc1a1/eaac1 glutamate transport activity by decreasing its affinity for glutamate. may be involved in membrane traffic (by similarity).
2935	
2936	
2937	
2938	
2939	
2940	
2941	
2942	
2943	
2944	
2945	
2946	dimethylates a single guanine residue at position 26 of most trnas using s-adenosyl-l-methionine as donor of the methyl groups.
2947	the lactotransferrin peptidase s60 domain 1 functions as a serine protease that cuts arginine rich regions. this function contributes to the antimicrobial activity.
2948	
2949	
2950	serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. may be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. may protect neurons from cell damage by tissue-type plasminogen activator.
2951	receptor for members of the ephrin-b family. binds to ephrin-b1, -b2 and -b3. may be involved in cell-cell interactions in the nervous system.
2952	copper chaperone for cytochrome c oxidase (cox). binds two copper ions and deliver them to the cu(a) site of cox (by similarity).
2953	
2954	
2955	
2956	
2957	growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. binds and activates vegfr-2 (flk1) and vegfr-3 (flt4) receptors.
2958	
2959	serves to link two monomer units of either igm or iga. in the case of igm, the j chain-joined dimer is a nucleating unit for the igm pentamer, and in the case of iga it induces larger polymers. it also help to bind these immunoglobulins to secretory component.
2960	component of the inner kinetochore plate. required for normal kinetochore assembly.
2961	
2962	the product of this enzyme, tetrahydrobiopterin (bh-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
2963	
2964	plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. exerts it highest activity toward 3-hydroxybutyryl-coa.
2965	
2966	
2967	
2968	
2969	enhances steroid receptor-mediated transcriptional activation as well as activating basal transcription (by similarity).
2970	enhances steroid receptor-mediated transcriptional activation as well as activating basal transcription (by similarity).
2971	functions as a calcium permeable cation channel. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis.
2972	synthesizes cyclic adp-ribose, a second messenger for glucose-induced insulin secretion. also has cadpr hydrolase activity. also moonlights as a receptor in cells of the immune system.
2973	
2974	may play an important role in development and maintenance of anterior structures. isoform ptx2c is involved in left-right asymmetry the developing embryo (by similarity).
2975	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. may be involved in the remodeling of the actin cytoskeleton. binds actin with high affinity both in the absence and presence of atp and its mechanochemical activity is inhibited by calcium ions. also acts as a gtpase activating protein on rho.
2976	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
2977	acts as catalytic component of the ccr4-not core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mrna deadenylase involved in mrna turnover. ccr4 has 3@#$%&-5@#$%& rnase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single stranded dna. discovered because of its role in the control of adh2 gene expression. it is required for the expression of genes involved in nonfermentative growth and it mediates or is required for the action of the spt6 and spt10 genes.
2978	
2979	low concentration of a soluble form of interleukin-6 receptor acts as an agonist of il6 activity.
2980	
2981	
2982	
2983	catalyzes the covalent attachment of ubiquitin to other proteins. required for postreplication repair of uv-damaged dna. may be involved in neurite outgrowth.
2984	
2985	binds to wasl/n-wasp and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (by similarity). may be involved in pre-mrna splicing.
2986	factor xii is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. prekallikrein is cleaved by factor xii to form kallikrein, which then cleaves factor xii first to alpha-factor xiia and then to beta-factor xiia. alpha- factor xiia activates factor xi to factor xia.
2987	tubulin-folding protein; involved in the early step of the tubulin folding pathway.
2988	
2989	
2990	involved in the biosynthesis of l2/hnk-1 carbohydrate epitope on both glycolipids and glycoproteins (by similarity).
2991	
2992	induces stromal cells to produce proinflammatory and hematopoietic cytokines (by similarity).
2993	acts preferentially on the c-jun n-terminal kinase (jnk) and p38 mapks. plays an important role in the heavy metal stress response by negatively regulating the kgb-1 (jnk-like) and the pmk-1 (p38-type) mapk signaling pathways.
2994	acts as a ligand for notch receptors. blocks the differentiation of progenitor cells into the b-cell lineage while promoting the emergence of a population of cells with the characteristics of a t-cell/nk-cell precursor.
2995	
2996	
2997	
2998	
2999	
3000	helicase; has atpase activity.
3001	
3002	
3003	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
3004	
3005	
3006	participates in the folding of proteins containing disulfide bonds (by similarity).
3007	has a role in pre-mrna splicing. phosphorylates sf2/asf.
3008	
3009	
3010	
3011	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
3012	
3013	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
3014	
3015	type i collagen is a member of group i collagen (fibrillar forming collagen).
3016	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
3017	
3018	the mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, zp1, zp2, zp3, and zp4. zp3 is essential for sperm binding and zona matrix formation.
3019	hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. may mediate an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
3020	required for 60s ribosomal subunit synthesis. probably involved in the processing of 27s rrna to produce mature 25s rrna.
3021	
3022	
3023	probable rho/rac effector that binds to the gtp-bound forms of rho and rac1. it probably binds p21 with a tighter specificity in vivo. dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. plays an important role in the regulation of cytokinesis and the development of the central nervous system.
3024	forms hydroxylysine residues in -xaa-lys-gly- sequences in collagens. these hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen crosslinks.
3025	responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain.
3026	transcriptional repressor involved in the regulation of cell growth. inhibits cell growth. binds to the consensus sequence 5@#$%&-ggtgtg-3@#$%&.
3027	catalyzes a base-exchange reaction in which the polar head group of phosphatidylcholine is replaced by l-serine (by similarity).
3028	
3029	
3030	acts as a transcriptional repressor.
3031	seems to function as an adapter protein. in adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. seems to couple transcription factor sox4 to the il-5 receptor (il5ra). may also play a role in vesicular trafficking. seems to be required for the targeting of tgfa to the cell surface in the early secretory pathway.
3032	
3033	may act as a chaperone.
3034	exhibits antimicrobial activity against gram-positive bacteria s.aureus and s.pyogenes, gram-negative bacteria p.aeruginosa and e.coli and the yeast c.albicans. kills multiresistant s.aureus and vancomycin-resistent e.faecium. no significant hemolytic activity was observed.
3035	receptor for the cytotoxic ligand tnfsf10/trail. the adapter molecule fadd recruits caspase-8 to the activated receptor. the resulting death-inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. promotes the activation of nf- kappa-b.
3036	transcriptional repressor. involved in the generation and migration of neural crest cells.
3037	
3038	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
3039	
3040	cleaves collagens of types i, ii, and iii at one site in the helical domain. also cleaves collagens of types vii and x.
3041	
3042	homophilic cell adhesion molecule that promotes axonal growth. may play a role in nerve regeneration and in the formation and function of other tissues. cell adhesion requires divalent cations.
3043	responsible for the biosynthesis of pyroglutamyl peptides. has a bias against acidic and tryptophan residues adjacent to the n-terminal glutaminyl residue and a lack of importance of chain length after the second residue.
3044	
3045	dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. probably plays a central role at and after the meiotic phase of spermatogenesis (by similarity).
3046	may act as a scaffold protein that may assemble active ikk-map3k14 complexes (ikka, ikkb and map3k14/nik).
3047	adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. association to the receptor is also mediated by the interaction with tradd. mediates activation of nf-kappa-b and jnk and is involved in apoptosis. the traf1/traf2 complex recruits the apoptotic suppressors birc2 and birc3 to tnfrsf1b/tnfr2. seems to be involved in il-15 signaling.
3048	implicated in vesicle trafficking to lysosomes. could be involved in processes related to cell division (by similarity).
3049	
3050	
3051	transport of small lipophilic substances (potential).
3052	cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.
3053	member of the cyclin-dependent kinase pair (cdk9/cyclin- t) complex, also called positive transcription elongation factor b (p-tefb), which facilitates the transition from abortive to production elongation by phosphorylating the ctd (c-terminal domain) of the large subunit of rna polymerase ii (rnap ii), supt5h and rdbp. the cdk9/cyclin-k complex has also a kinase activity toward ctd of rnap ii and can substitute for p-tefb in vitro.
3054	
3055	appears to function in modulating the activity of the immune system during the acute-phase reaction.
3056	catalyzes fat and vitamin absorption. acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.
3057	required for vesicle docking or fusion during acrosome biogenesis (by similarity). may play a role in rna trafficking or localization. in case of infection by hiv-1, acts as a cofactor for viral rev and promotes movement of rev-responsive element- containing rnas from the nuclear periphery to the cytoplasm. this step is essential for hiv-1 replication.
3058	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. this receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system.
3059	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
3060	interconversion of serine and glycine.
3061	putative receptor for purines coupled to g-proteins (by similarity).
3062	
3063	protein kinase acting as a corepressor of several transcription factors, including smad1 and pou4f1/brn3a and probably nk homeodomain transcription factors. inhibits cell growth and promotes apoptosis. involved in transcriptional activation of tp53 and tp73. phosphorylation of tp53 may be mediated by a tp53-hipk2-axin1 complex. in response to tgfb, cooperates with daxx to activate jnk. phosphorylates the antiapoptotic factor ctbp1 and promotes its proteasomal degradation. in the wnt/beta-catenin signaling pathway acts as an intermediate kinase between tak1 and nlk to promote the proteasomal degradation of c-myb (by similarity).
3064	calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis (by similarity).
3065	
3066	
3067	thought to form a receptor-activated non-selective calcium permeant cation channel. probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or g-protein coupled receptors. may also be activated by intracellular calcium store depletion.
3068	calcium-dependent mitochondrial aspartate and glutamate carrier. may have a function in the urea cycle.
3069	
3070	may play a role in junctional plaques.
3071	
3072	
3073	collagen type iv is specific for basement membranes. vital for embryonic development.
3074	
3075	
3076	catalyzes the cleavage of 5-oxo-l-proline to form l- glutamate coupled to the hydrolysis of atp to adp and inorganic phosphate.
3077	
3078	this is an intracellular thiol proteinase inhibitor.
3079	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
3080	
3081	hydrolyzes an epoxide moiety of lta(4) to form ltb(4). the enzyme also has some peptidase activity (by similarity).
3082	part of the ap-3 complex, an adaptor-related complex which is not clathrin-associated. the complex is associated with the golgi region as well as more peripheral structures. it facilitates the budding of vesicles from the golgi membrane and may be directly involved in trafficking to lysosomes.
3083	
3084	
3085	
3086	cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity.
3087	
3088	muscle contraction.
3089	side-chain deamidation of n-terminal asparagine residues to aspartate. required for the ubiquitin-dependent turnover of intracellular proteins that initiate with met-asn. these proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of n-acetyl methionine by acylaminoacid hydrolase (aah). conversion of the resulting n- terminal asparagine to aspartate by pnad renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the n-end rule. this enzyme does not act on substrates with internal or c-terminal asparagines and does not act on glutamine residues in any position.
3090	
3091	
3092	
3093	
3094	
3095	chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. inhibits proliferation of myeloid progenitors in colony formation assays. may be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. c-terminal processed forms have been shown to be equally chemotactically active for leukocytes. possesses antibacterial activity e.coli atcc 25922 and s.aureus atcc 29213.
3096	
3097	
3098	
3099	
3100	necessary for cellular interactions with laminin and the extracellular matrix.
3101	
3102	sequence-specific rna-binding protein that regulates translation and mrna stability by binding the 3@#$%& untranslated regions (utrs) of mrna targets. may be required to support proliferation and self-renewal of stem cells (by similarity).
3103	involved in cytokinesis (potential).
3104	component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. three proteases; ndl, gd and snk process easter to create active easter. active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the tl receptor in the ventral region of the embryo. promotes heterophilic cellular adhesion. spz c-106 in the hemolymph controls expression of the antifungal peptide drosomycin (drs) by acting as a ligand of tl and inducing an intracellular signaling pathway.
3105	may be involved in the physiological processes of brain function. has no dipeptidyl aminopeptidase activity. may modulate the cell surface expression and the activity of the potassium channel kcnd2 (by similarity).
3106	
3107	inhibits factor x (x(a)) directly and, in a xa-dependent way, inhibits viia/tissue factor activity, presumably by forming a quaternary xa/laci/viia/tf complex. it possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
3108	
3109	
3110	
3111	catalyzes the conversion of delta8-sterols to their corresponding delta7-isomers.
3112	
3113	isoform c is proteolytically inactive.
3114	
3115	
3116	associated to surface igm-receptor; may be involved in signal transduction. may be involved in regulation of the catalytic activity of type 2a-related serine/threonine phosphatases.
3117	associated to surface igm-receptor; may be involved in signal transduction. may be involved in regulation of the catalytic activity of type 2a-related serine/threonine phosphatases.
3118	could be involved in the transport of heme from the mitochondria to the cytosol. plays a central role in the maturation of cytosolic iron-sulfur (fe/s) cluster-containing proteins.
3119	
3120	
3121	
3122	
3123	
3124	
3125	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
3126	
3127	required for pseudopod elongation in transformed cells.
3128	
3129	
3130	component of the anaphase promoting complex/cyclosome (apc/c), a cell cycle-regulated e3 ubiquitin ligase that controls progression through mitosis and the g1 phase of the cell cycle.
3131	
3132	
3133	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
3134	
3135	
3136	plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ets1-mediated transcription of erythroid-specific genes in myeloid cells (by similarity).
3137	export receptor for importin-alpha. mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. in the nucleus binds cooperatively to importin-alpha and to the gtpase ran in its active gtp-bound form. docking of this trimeric complex to the nuclear pore complex (npc) is mediated through binding to nucleoporins. upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of ran-gtp to ran-gdp (induced by ranbp1 and rangap1, respectively) cause release of the importin-alpha from the export receptor. cse1l/xpo2 then return to the nuclear compartment and mediate another round of transport. the directionality of nuclear export is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus.
3138	this protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
3139	
3140	
3141	
3142	
3143	motor for anterograde axonal transport of synaptic vesicle precursors (by similarity).
3144	
3145	involved in tethering the chromosomes to the spindle pole and in chromosome movement. microtubule-based anterograde translocator for membranous organelles. plus end-directed microtubule sliding activity in vitro (by similarity).
3146	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
3147	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
3148	adenosylhomocysteine is a competitive inhibitor of s- adenosyl-l-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
3149	
3150	has peptide-independent atpase activity.
3151	
3152	receptor for interferons alpha and beta. binding to type i ifns triggers tyrosine phosphorylation of a number of proteins including jaks, tyk2, stat proteins and ifnr alpha- and beta- subunits themselves.
3153	inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium.
3154	shows activity against influenza virus and vsv, a rhabdovirus.
3155	
3156	collagen type iv is specific for basement membranes. vital for embryonic development.
3157	may play a role in rna metabolism.
3158	catalyzes the initial step in the synthesis of dolichol- p-p-oligosaccharides.
3159	tautomerization of d-dopachrome with decarboxylation to give 5,6-dihydroxyindole (dhi).
3160	
3161	catalyzes the transfer of ptdins and phosphatidylcholine between membranes.
3162	
3163	
3164	
3165	in muscle, the calcium-binding protein parvalbumin is thought to be involved in muscle relaxation.
3166	
3167	may activate the map kinase signaling pathway.
3168	
3169	probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. is not an essential protein. involved in substrate recognition in ubiquitin-dependent degradation.
3170	transcriptional repressor of genes that require a bhlh protein for their transcription. may act as a negative regulator of myogenesis by inhibiting the functions of myod1 and ash1 (by similarity).
3171	
3172	thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (caz) which regulates neurotransmitter release. seems to act together with bsn. may recruit liprin-alpha proteins to the caz.
3173	
3174	
3175	neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. seems to play role in formation or maintenance of synaptic junctions. in vitro, triggers the de novo formation of presynaptic structures. may be involved in specification of excitatory synapses.
3176	
3177	
3178	the elongation of primed dna templates by dna polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (pcna) and activator 1. the 37 kda subunit may be involved in the elongation of the multiprimed dna template.
3179	could be a global transcriptional regulator. modifies gene expression by affecting chromatin (potential).
3180	transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. required for the differentiation of pancreatic islet alpha cells (by similarity). competes with pax4 in binding to a common element in the glucagon, insulin and somatostatin promoters (by similarity). isoform 5a appears to function as a molecular switch that specifies target genes.
3181	
3182	
3183	catalyzes the adenylation by atp of the carboxyl- terminal glycine of this.
3184	
3185	
3186	receptor for members of the ephrin-a family. binds to ephrin-a1, -a2, -a3, -a4 and -a5.
3187	
3188	
3189	calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. is not activated by phorbol esters or diaglycerol. may play a role in the secretory response to nutrients. involved in cell polarization processes and the formation of epithelial tight junctions.
3190	
3191	
3192	
3193	
3194	cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. chemotactic for activated t-cells. binds to cxcr3.
3195	interacts with c-terminus of pcna. 5@#$%& phosphate residue is required for binding of the n-terminal dna-binding domain to duplex dna, suggesting a role in recognition of non-primer template dna structures during replication and/or repair.
3196	
3197	
3198	catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate.
3199	
3200	
3201	presumably involved in the processing and regular turnover of intracellular proteins. catalyzes the removal of unsubstituted n-terminal amino acids from various peptides.
3202	may be involved in several stages of intracellular trafficking (by similarity).
3203	
3204	
3205	
3206	required for autophagy.
3207	
3208	catalyzes the posttranslational formation of 4- hydroxyproline in -xaa-pro-gly- sequences in collagens and other proteins.
3209	
3210	
3211	interacts with zinc finger protein a20/tnfaip3 and inhibits tnf-induced nf-kappa-b-dependent gene expression by interfering with an rip- or traf2-mediated transactivation signal (by similarity). increases cell surface cd4(t4) antigen expression. interacts with hiv-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. may regulate matrix nuclear localization, both nuclear import of pic (preintegration complex) and export of gag polyprotein and viral genomic rna during virion production.
3212	binds single-stranded rna. has a high affinity for g- rich and u-rich regions of hnrna. also binds to apob mrna transcripts around the rna editing site.
3213	
3214	may be the gtpase, regulating atp sulfurylase activity.
3215	the mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, zp1, zp2, zp3, and zp4. zp1 ensures the structural integrity of the zona pellucida.
3216	
3217	regulatory subunit of the calcium activated potassium kcnma1 (maxik) channel. modulates the calcium sensitivity and gating kinetics of kcnma1, thereby contributing to kcnma1 channel diversity. increases the apparent ca(2+)/voltage sensitivity of the kcnma1 channel. it also modifies kcnma1 channel kinetics and alters its pharmacological properties. it slows down the activation and the deactivation kinetics of the channel. acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to kcnma1. its presence is also a requirement for internal binding of the kcnma1 channel opener dehydrosoyasaponin i (dhs-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (e2). increases the binding activity of charybdotoxin (ctx) toxin to kcnma1 peptide blocker by increasing the ctx association rate and decreasing the dissociation rate.
3218	
3219	
3220	hydrolyzes fatty acids from s-acylated cysteine residues in proteins such as trimeric g alpha proteins or hras. also has low lysophospholipase activity.
3221	
3222	
3223	
3224	
3225	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
3226	general transcription factor that functions at the core of the dna-binding multiprotein factor tfiid. binding of tfiid to the tata box is the initial transcriptional step of the pre- initiation complex (pic), playing a role in the activation of eukaryotic genes transcribed by rna polymerase ii.
3227	
3228	
3229	cleaves the glcnac-asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
3230	
3231	required for checkpoint mediated cell cycle arrest in response to dna damage within both the s phase and g2/m phases of the cell cycle. may serve as a scaffold for the recruitment of dna repair and signal transduction proteins to discrete foci of dna damage marked by ser-139 phosphorylation of histone h2afx. also required for downstream events subsequent to the recruitment of these proteins. these include phosphorylation and activation of the atm, chek1/chk1 and chek2/chk2/cds1 kinases, and stabilization of tp53 and apoptosis. atm and chek2 may also be activated independently by a parallel pathway mediated by tp53bp1.
3232	derived from proteolytic degradation of complement c4, c4a anaphylatoxin is a mediator of local inflammatory process. it induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
3233	
3234	hydrolyzes n(g),n(g)-dimethyl-l-arginine (adma) and n(g)-monomethyl-l-arginine (mma) which act as inhibitors of nos. has therefore a role in nitric oxide generation.
3235	
3236	receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
3237	binds to scaffold/matrix attachment region (s/mar) dna and forms a molecular assembly point to allow the formation of a @#$%&transcriptosomal@#$%& complex (consisting of sr proteins and rna polymerase ii) coupling transcription and rna processing.
3238	enhances nf-kappa-b, srf and ap1 transactivation.
3239	
3240	probably involved in connections of major cytoskeletal structures to the plasma membrane.
3241	interconverts glcnac-6-p and glcnac-1-p.
3242	tumor suppressor that may be involved in interferon- dependent cell death (by similarity).
3243	induces cartilage and bone formation.
3244	phm and phv also cause vasodilation.
3245	major connective tissue mitoattractant secreted by vascular endothelial cells. promotes proliferation and differentiation of chondrocytes. mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. enhances fibroblast growth factor-induced dna synthesis.
3246	protein kinase that plays an important role in cellular stress response. activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic foxo3a. phosphorylates nedd4l, which leads to its inactivation and to the subsequent activation of various channels and transporters such as enac, kv1.3, or eaat1.
3247	
3248	
3249	inhibits dna replication by preventing the incorporation of mcm complex into prereplication complex (pre-rc). it is degraded during the mitotic phase of the cell cycle. its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
3250	
3251	mediates potential-dependent transport of a variety of organic cations. may play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
3252	
3253	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
3254	
3255	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
3256	forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
3257	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l.
3258	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l.
3259	single-stranded nucleic acid binding protein that binds preferentially to oligo dc (by similarity).
3260	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
3261	active on amp and damp with atp as a donor. when gtp is used as phosphate donor, the enzyme phosphorylates amp, cmp, and to a small extent dcmp.
3262	catalyzes the formation of gdp-l-fucose from gtp and l- fucose-1-phosphate. functions as a salvage pathway to reutilize l- fucose arising from the turnover of glycoproteins and glycolipids.
3263	
3264	
3265	receptor for members of the ephrin-b family.
3266	may play a role in b-lineage commitment and/or modulation of signaling through the b-cell receptor.
3267	factor h functions as a cofactor in the inactivation of c3b by factor i and also increases the rate of dissociation of the c3bbb complex (c3 convertase) and the (c3b)nbb complex (c5 convertase) in the alternative complement pathway.
3268	
3269	possesses significant protein thiol-disulfide oxidase activity.
3270	straight-chain enoyl-coa thioesters from c4 up to at least c16 are processed, although with decreasing catalytic rate.
3271	involved in mrna splicing and in the nonsense mediated decay (nmd) pathway.
3272	
3273	cell surface receptor for reelin (reln) and apolipoprotein e (apoe)-containing ligands. lrp8 participates in transmitting the extracellular reelin signal to intracellular signaling processes, by binding to dab1 on its cytoplasmic tail. reelin acts via both the vldl receptor (vldlr) and lrp8 to regulate dab1 tyrosine phosphorylation and microtubule function in neurons. lrp8 has higher affinity for reelin than vldlr. lrp8 is thus a key component of the reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. binds the endoplasmic reticulum resident receptor-associated protein (rap). binds dimers of beta 2-glycoprotein i and may be involved in the suppression of platelet aggregation in the vasculature. highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (phgpx), two proteins required for sperm maturation. may also function as an endocytic receptor.
3274	
3275	
3276	
3277	required for meiotic chromosome synapsis and cell cycle progression. may act as a molecular zipper to bring homologous chromosomes in close apposition. zip1 may encode the transverse filaments of the synaptonemal complex.
3278	orphan receptor; possibly for a chemokine.
3279	recruited and tyrosine phosphorylated by several receptor systems, for example the t-cell, leptin and insulin receptors. once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to sh2 and sh3 domain- containing proteins. role in g2-m progression in the cell cycle. represses cbp-dependent transcriptional activation apparently by competing with other nuclear factors for binding to cbp. also acts as a putative regulator of mrna stability and/or translation rates and mediates mrna nuclear export. isoform 3 is only expressed in growth-arrested cells and inhibits s phase entry.
3280	
3281	this small ubiquitous enzyme is essential for maintenance and cell growth.
3282	
3283	required for stability of pex5 and protein import into the peroxisome matrix. anchored by pex26 to peroxisome membranes, possibly to form heteromeric aaa atpase complexes required for the import of proteins into peroxisomes.
3284	involved in the maintenance of golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and golgi. involved in hormone-induced steroid biosynthesis in testicular leydig cells (by similarity).
3285	anchors the lamina and the heterochromatin to the inner nuclear membrane.
3286	
3287	
3288	cleaves ubiquitin fusion protein substrates. binds to the herpes virus protein vmw110 which may therefore modulate its substrate specificity or activity to stabilize viral proteins.
3289	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
3290	efficient protease with alanine specificity but only little elastolytic activity.
3291	part of the dynein complex of respiratory cilia.
3292	phosphorylates ptdins and ptdins4p with a preference for ptdins. does not phosphorylate ptdins(4,5)p2. may be involved in egf and pdgf signaling cascades.
3293	receptor for the fc region of igg. binds complexed or aggregated igg and also monomeric igg. mediates antibody-dependent cellular cytotoxicity (adcc) and other antibody-dependent responses, such as phagocytosis.
3294	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. activity on g(z)-alpha is inhibited by phosphorylation of the g-protein. activity on g(z)-alpha and g(i)-alpha-1 is inhibited by palmitoylation of the g-protein.
3295	seems to mediate adhesion by cell surface integrin binding. may serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment.
3296	rna-binding protein that binds to several small cytoplasmic rna molecules known as y rnas. may stabilize these rnas from degradation.
3297	may be involved in transcriptional regulation.
3298	binds to tgf-beta. could be involved in capturing and retaining tgf-beta for presentation to the signaling receptors.
3299	functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. upon ligand activation through the released notch intracellular domain (nicd) it forms a transcriptional activator complex with rbp-j kappa and activates genes of the enhancer of split locus. affects the implementation of differentiation, proliferation and apoptotic programs (by similarity).
3300	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
3301	
3302	inhibitory effect on stress fiber organization. may down-regulate rho-like gtpase in hematopoietic cells.
3303	involved in the regulation of the microtubule (mt) filament system by destabilizing microtubules. it prevents assembly and promotes disassembly of microtubules.
3304	
3305	
3306	
3307	
3308	the first ptpase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
3309	
3310	
3311	
3312	adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. can bind to fibrinogen, fibronectin, laminin and type v collagen.
3313	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking among different compartments. modulates vesicle budding and uncoating within the golgi complex. deactivation induces the redistribution of the entire golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. in its gtp-bound form, its triggers the association with coat proteins with the golgi membrane. the hydrolysis of arf1-bound gtp, which is mediated by arfgaps proteins, is required for dissociation of coat proteins from golgi membranes and vesicles.
3314	essential for recycling gmp and indirectly, cgmp.
3315	involved in the cell-cell adhesion. has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with igsf4, pvrl1 and pvrl3. interaction with epb41l1 may regulate structure or function of cell-cell junctions (by similarity).
3316	
3317	
3318	seems to act on cbl. may play a role in regulating the function of cbl and its associated protein kinases.
3319	may play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath (by similarity).
3320	binds to the fc region of immunoglobulins gamma. low affinity receptor. by binding to igg it initiates cellular responses against pathogens and soluble antigens.
3321	
3322	
3323	motor required for the retrograde transport of golgi vesicles to the endoplasmic reticulum. has a microtubule plus end- directed motility.
3324	may regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-er compartment.
3325	may play a role in the signal transduction pathway mediated by multiple wnt genes.
3326	
3327	involved in the degradation of asparagine-linked glycoproteins. hydrolyze of n-acetyl-beta-d-glucosamine (1-4)n- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.
3328	belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (ajs). may connect the nectin-afadin and e- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at ajs through afadin and alpha-actinin (by similarity).
3329	hydrolyzes n(g),n(g)-dimethyl-l-arginine (adma) and n(g)-monomethyl-l-arginine (mma) which act as inhibitors of nos. has therefore a role in nitric oxide generation.
3330	
3331	catalyzes the 6-electron oxidation of protoporphyrinogen ix to form protoporphyrin ix.
3332	plays an important role in the de novo pathway of purine nucleotide biosynthesis.
3333	
3334	
3335	its physiological substrate seems to be the small heat shock protein (hsp27/hsp25). in vitro can phosphorylate glycogen synthase at ser-7 and tyrosine hydroxylase (on ser-19 and ser-40). this kinase phosphorylates ser in the peptide sequence, hyd-x-r- x(2)-s, where hyd is a large hydrophobic residue (by similarity). mediates both erk and p38 mapk/mapk14 dependent neutrophil responses. participates in tnf alpha-stimulated exocytosis of secretory vesicles in neutrophils. plays a role in phagocytosis- induced respiratory burst activity.
3336	
3337	transcription factor that recognizes and binds to the enhancer heptamer motif 5@#$%&-tga[cg]tca-3@#$%&.
3338	exchange factor for gtp-binding proteins rhoa, rhog and, to a lesser extent, rac1. binds physically to the nucleotide-free states of those gtpases.
3339	functions as a sorting receptor in the golgi compartment and as a clearance receptor on the cell surface. required for protein transport from the golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (m6pr). also required for protein transport from the golgi apparatus to the endosomes. promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of bdnf (probdnf) and ngfb (prongfb). also acts as a receptor for neurotensin. may promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular lpl. probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter slc2a4/glut4 (glut4 storage vesicles, or gsvs). these vesicles provide a stable pool of slc2a4 and confer increased responsiveness to insulin. may also mediate transport from the endoplasmic reticulum to the golgi.
3340	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
3341	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. ladsin exerts cell- scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.
3342	
3343	
3344	
3345	may act as a modulator against excess calcium accumulation in normal human mammary epithelial cells. may also play a role in suppressing tumor cell growth.
3346	
3347	adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. mediates activation of nf-kappa-b and probably jnk. seems to be involved in apoptosis.
3348	
3349	may play a role in the regulation of t and b-lymphocyte development and signal transduction.
3350	regulates myosin phosphatase activity. augments ca(2+) sensitivity of the contractile apparatus.
3351	catalyzes the conversion of phosphatidic acid (pa) to diacylglycerol (dg). in addition it hydrolyzes lysophosphatidic acid (lpa), ceramide-1-phosphate (c-1-p) and sphingosine-1- phosphate (s-1-p). the relative catalytic efficiency is lpa = pa > c-1-p > s-1-p. may be involved in cell adhesion and in cell-cell interactions.
3352	required for protein transport from the er to the golgi complex.
3353	promotes the fragmentation of the mitochondrial network and its perinuclear clustering. can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. also mediates peroxisomal fission.
3354	
3355	
3356	part of a complex implicated in the control of actin polymerization in cells.
3357	calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. is not activated by phorbol esters or diaglycerol. may play a role in the secretory response to nutrients. involved in cell polarization processes and the formation of epithelial tight junctions.
3358	
3359	
3360	
3361	
3362	inhibits interleukin-2 (il-2) gene expression. may be responsible for transcriptional repression of the il-2 gene. enhances or represses the promoter activity of the atp1a1 gene depending on the quantity of cdna and on the cell type.
3363	required for the proper development and maintenance of neurons presumably by affecting rna metabolism.
3364	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
3365	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i.
3366	
3367	
3368	
3369	
3370	provides the precursors necessary for dna synthesis. catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
3371	involved in mitochondrial transcription regulation. required for accurate and efficient promoter recognition by the mitochondrial rna polymerase. activates transcription by binding immediately upstream of transcriptional start sites. is able to unwind and bend dna.
3372	membrane-cytoskeleton linker. the neural-specific isoforms may participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of ranvier and axonal initial segments.
3373	
3374	major isoenzyme hydrolyzing the calcium-mobilizing second messenger ins(1,4,5)p3, this is a signal-terminating reaction.
3375	required for kinetochore localization of bub1.
3376	involved in skeletal muscle regeneration, specifically at the onset of cell fusion. also involved in macrophage-derived giant cells (mgc) and osteoclast formation from mononuclear precursors (by similarity).
3377	
3378	
3379	component of multiple cytoplasmic organelles. apparently crucial for their normal development and function. may be involved in intracellular protein sorting.
3380	
3381	
3382	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
3383	
3384	membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. binds to calmodulin.
3385	
3386	binds dna through the consensus sequence 5@#$%&-caatg-3@#$%&. may be involved in transcriptional regulation and may play a role in tooth formation (by similarity).
3387	catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a thr-glu-tyr sequence located in map kinases. activates erk1 and erk2 map kinases.
3388	
3389	
3390	may act as scaffold protein (by similarity). may play a role in the development of the retina. has been suggested to play a role in axon guidance.
3391	
3392	
3393	
3394	
3395	
3396	
3397	
3398	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
3399	
3400	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
3401	
3402	required for membrane traffic to the vacuole.
3403	
3404	voltage insensitive, instantaneous, outwardly rectifying potassium channel. outward rectification is reversed at high external k(+) concentrations.
3405	putative transcription factor. involved in hair formation and spermatogenesis. may function in the differentiation and/or maintenance of the urogenital system (by similarity).
3406	may contribute to the organization of cell structure. the sh3 motif may function as a binding region to cytoskeleton. tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.
3407	essential for the control of the cell cycle at the g1/s (start) transition.
3408	
3409	cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (by similarity).
3410	
3411	may be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. able to restore partial locomotion and axonal fasciculation to c.elegans unc-76 mutants in germ-line transformation experiments.
3412	adapter involved in the tlr4 signaling pathway in the innate immune response. acts via irak2 and traf-6, leading to the activation of nf-kappa-b, mapk1, mapk3 and jnk, resulting in cytokine secretion and the inflammatory response.
3413	
3414	may play a role in the regulation of hemostasis. the soluble form may have inhibitory properties towards coagulation factors. may interact with cellular g-protein signaling pathways. may bind to the dna 5@#$%&-gtcacatg-3@#$%&(cdei box).
3415	
3416	component of e3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. seems to be involved poteosomal degradation of p53/tp53 stimulated by adenovirus e1b-55 kda protein. may form a cell surface vasopressin receptor.
3417	
3418	
3419	likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the rxxx[kr]r consensus motif.
3420	
3421	
3422	
3423	binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with e1, e2, and e3 (by similarity).
3424	reversible hydration of carbon dioxide.
3425	receptor for il-10; binds il-10 with a high affinity.
3426	inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. this suggests that it delays the catabolism of triglyceride-rich particles.
3427	it is able to complement the radiosensitivity defect of an ataxia telangiectasia (at) fibroblast cell line.
3428	
3429	may regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-er compartment.
3430	
3431	
3432	may be involved in signal transduction as a component of a multimeric receptor complex.
3433	cleaves the glcnac-asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
3434	cleaves the glcnac-asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
3435	cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the glc(2)man(9)glcnac(2) oligosaccharide precursor of immature glycoproteins.
3436	membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. it plays a role in fatty-acid desaturation and is also involved in several steps of the sterol biosynthesis pathway, particularly in the 4- demethylation of the 4,4@#$%&-dimethyl zymosterol.
3437	may be involved in the regulation of gene expression as repressor and activator. the repression might be related to covalent modification of histone proteins.
3438	
3439	converts sphingomyelin to ceramide. asm also has phospholipase c activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.
3440	
3441	may have e3 ubiquitin ligase activity.
3442	
3443	
3444	
3445	ucp are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. as a result, energy is dissipated in the form of heat. may play a role in the modulation of tissue respiratory control. participates in thermogenesis and energy balance.
3446	
3447	
3448	upstream regulator of interferon-induced serine/threonine protein kinase r (pkr). may block the pkr- inhibitory function of p58ipk, resulting in restoration of kinase activity and suppression of cell growth.
3449	
3450	protein transport. regulator of membrane traffic from the golgi apparatus towards the endoplasmic reticulum (er). has a low gtpase activity.
3451	
3452	
3453	
3454	
3455	
3456	golgi auto-antigen; probably involved in maintaining golgi structure.
3457	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
3458	endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). may also play a role in neovascularization or angiogenesis. hydrolyzes collagen type iv, laminin, nidogen, nascin-c isoform, fibronectin, and type i gelatin.
3459	endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). may also play a role in neovascularization or angiogenesis. hydrolyzes collagen type iv, laminin, nidogen, nascin-c isoform, fibronectin, and type i gelatin.
3460	mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.
3461	
3462	
3463	component of the dystrophin-glycoprotein complex (dgc), a complex that spans the muscle plasma membrane and forms a link between the f-actin cytoskeleton and the extracellular matrix. preferentially associates with the sarcoglycan subcomplex of the dgc.
3464	receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
3465	
3466	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
3467	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
3468	the beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating g protein inhibition and controlling the alpha-1 subunit membrane targeting.
3469	in vitro; can phosphorylate exogenous substrates on ser and thr residues. may be involved in the regulation of cellular growth and/or development.
3470	major cellular poly(rc)-binding protein. binds also poly(ru).
3471	
3472	
3473	
3474	subunit of atp-sensitive potassium channels (katp). can form cardiac and smooth muscle-type katp channels with kir6.2. kir6.2 forms the channel pore while sur2 is required for activation and regulation.
3475	plays a role as a receptor for the recognition of mhc class i hla-e molecules by nk cells and some cytotoxic t-cells.
3476	
3477	transcriptional activator. able to bind to two different type of dna binding sites. isoform foxj2.l behaves as a more potent transactivator than foxj2.s.
3478	transport of phosphorylated lysosomal enzymes from the golgi complex and the cell surface to lysosomes. lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low ph mediates the dissociation of the complex.
3479	
3480	
3481	
3482	associates with the organic matrix of bone and cartilage. thought to act as an inhibitor of bone formation.
3483	the s.cerevisiae ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-amp.
3484	
3485	
3486	involved in several cell fate decisions that require cell-cell interactions. it is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10.
3487	may be involved in the pdh (pyruvate dehydrogenase complex) bypass.
3488	interacts with the viral protein-binding domain of the retinoblastoma protein.
3489	interacts with the viral protein-binding domain of the retinoblastoma protein.
3490	involved in the regulation of cell growth. may stabilize the active cdc2-cyclin b1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. may act as tumor suppressor.
3491	
3492	ribosomal protein p0 is the functional equivalent of e.coli protein l10.
3493	possesses gtpase activity.
3494	possesses gtpase activity.
3495	contactins mediate cell surface interactions during nervous system development. involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with cntnap1. participates in oligodendrocytes generation by acting as a ligand of notch1. its association with notch1 promotes notch1 activation through the released notch intracellular domain (nicd) and subsequent translocation to the nucleus. interaction with tnr induces a repulsion of neurons and an inhibition of neurite outgrowth (by similarity).
3496	regulates myosin phosphatase activity.
3497	
3498	interacts specifically with a number of opioid ligands. receptor for neuropeptides b and w, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. has a higher affinity for neuropeptide b.
3499	
3500	cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in dna repair, and in apoptosis. the cohesin complex is required for the cohesion of sister chromatids after dna replication. the cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. at metaphase-anaphase transition, this protein is cleaved by espl1 and dissociates from chromatin, allowing sister chromatids to segregate. the cohesin complex may also play a role in spindle pole assembly during mitosis. also plays a role in apoptosis, via its cleavage by caspase-3/casp3 or caspase-7/casp7 during early steps of apoptosis: the c-terminal 64 kda cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
3501	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
3502	
3503	
3504	
3505	cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. also permeable for ca(2+), li(+) and k(+). generates a biphasic current with a fast inactivating and a slow sustained phase. mediates glutamate-independent ca(2+) entry into neurons upon acidosis. this ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. heteromeric channel assembly seems to modulate channel properties.
3506	
3507	orphan nuclear receptor. represses transcription and binds dna as a homodimer. binds the ir7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism (by similarity).
3508	actin-binding protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia.
3509	probably acts as a regulator of other genes. forms a complex with adenovirus e1a and with sv40 large t antigen. acts as a tumor suppressor. may bind and modulate functionally certain cellular proteins with which t and e1a compete for pocket binding. potent inhibitor of e2f-mediated trans-activation. recruits and targets histone methyltransferase suv39h1 leading to epigenetic transcriptional repression. inhibits the intrinsic kinase activity of taf1.
3510	
3511	potential calcium-dependent cell-adhesion protein.
3512	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
3513	
3514	may have a growth inhibitory role.
3515	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
3516	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
3517	protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation.
3518	
3519	functions in nuclear protein import as nuclear transport receptor. serves as receptor for nuclear localization signals (nls) in cargo substrates. is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (npc) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus (by similarity). mediates the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones.
3520	type iv collagen is the major structural component of glomerular basement membranes (gbm), forming a @#$%&chicken-wire@#$%& meshwork together with laminins, proteoglycans and entactin/nidogen.
3521	
3522	potential calcium-dependent cell-adhesion protein.
3523	
3524	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
3525	factor xa is a vitamin k-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor va, calcium and phospholipid during blood clotting.
3526	
3527	may be involved in tissue injury and remodeling. has significant elastolytic activity. can accept large and small amino acids at the p1@#$%& site, but has a preference for leucine. aromatic or hydrophobic residues are preferred at the p1 site, with small hydrophobic residues (preferably alanine) occupying p3 (by similarity).
3528	
3529	
3530	catalyzes the hydrolysis of gtp bound to the 40s ribosomal initiation complex (40s.mrna.met-trna[f].eif-2.gtp) with the subsequent joining of a 60s ribosomal subunit resulting in the release of eif-2 and the guanine nucleotide. the subsequent joining of a 60s ribosomal subunit results in the formation of a functional 80s initiation complex (80s.mrna.met-trna[f]).
3531	
3532	
3533	inhibits activated protein c as well as plasminogen activators.
3534	
3535	
3536	may be a mediator of metastasis suppression in breast carcinoma (by similarity).
3537	
3538	this rnase has marked specificity towards the 3@#$%& side of uridine nucleotides.
3539	pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
3540	
3541	
3542	may play a role in the response to environmental stress. appears to act upstream of the jun n-terminal pathway.
3543	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
3544	
3545	tumor-suppressor protein involved in t-cell lymphomas. may function on the p53-signaling pathway. may be a key regulator of both differentiation and survival during thymocyte development. repress transcription through direct, tfcoup2-independent binding to a gc-rich response element (by similarity).
3546	may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (by similarity).
3547	may enhance gap-43 expression by binding to the ngf- regulatory region of its mrna (by similarity).
3548	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
3549	
3550	
3551	
3552	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. may be involved in the remodeling of the actin cytoskeleton. binds actin with high affinity both in the absence and presence of atp and its mechanochemical activity is inhibited by calcium ions. also acts as a gtpase activating protein on rho.
3553	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
3554	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
3555	
3556	recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. seems to be the key enzyme in the formation of an ra gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (by similarity).
3557	
3558	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
3559	integrin alpha-11/beta-1 is a receptor for collagen.
3560	catalyzes the first committed step in the biosynthesis of complex n-glycans. it controls conversion of high mannose to complex n-glycans; the final hydrolytic step in the n-glycan maturation pathway.
3561	
3562	
3563	
3564	
3565	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. most active in catalyzing 2-hydroxylation. caffeine is metabolized primarily by cytochrome cyp1a2 in the liver through an initial n3-demethylation. also acts in the metabolism of aflatoxin b1 and acetaminophen.
3566	
3567	co-chaperone of hsc70. seems to play a role in protein import into mitochondria.
3568	adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. can bind to fibrinogen, fibronectin, laminin, type v collagen and integrins alpha-v/beta-1, alpha- v/beta-3 and alpha-iib/beta-3.
3569	
3570	type i collagen is a member of group i collagen (fibrillar forming collagen).
3571	could be involved in cell-cell interactions.
3572	could be involved in cell-cell interactions.
3573	could be involved in cell-cell interactions.
3574	
3575	
3576	e-cad/ctf2 promotes non-amyloidogenic degradation of abeta precursors. has a strong inhibitory effect on app c99 and c83 production.
3577	
3578	the nuclear isoform (1/nop30) may be involved in rna splicing and the cytoplasmic isoform (2/myp) may inhibit apoptosis.
3579	
3580	
3581	
3582	dna repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. may be involved in interstrand dna cross-link repair and in the maintenance of normal chromosome stability.
3583	
3584	attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to na-k atpase, to the lymphocyte membrane protein gp85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. in skeletal muscle, isoform mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
3585	
3586	binds fibroblast growth factor and e-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils).
3587	
3588	phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin i. the beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation.
3589	
3590	this is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters. may be considered as a novel component of the nf-kappa-b signaling axis responsible for the survival and activation of b-cells after bcr cross-linking (by similarity).
3591	
3592	
3593	the enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin k-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
3594	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (by similarity).
3595	cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases (by similarity).
3596	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
3597	
3598	involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl coa ester.
3599	
3600	
3601	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
3602	integrin alpha-l/beta-2 is a receptor for icam1, icam2, icam3 and icam4. it is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic t-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
3603	
3604	
3605	probable component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. may be required to regulate the atp- dependent activity (by similarity).
3606	
3607	
3608	muscle contraction.
3609	catalyzes the desaturation of very long chain acyl-coas to 2-trans-enoyl-coas.
3610	
3611	possible transcription factor. specifically binds to the ct/gc-rich region of the interleukin-3 promoter and mediates tax transactivation of il-3.
3612	
3613	involved in the homologous recombination repair (hrr) pathway of double-stranded dna breaks arising during dna replication or induced by dna-damaging agents. the rad51b-rad51c dimer exhibits single-stranded dna-dependent atpase activity. the bcdx2 complex binds single-stranded dna, single-stranded gaps in duplex dna and specifically to nicks in duplex dna.
3614	
3615	
3616	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. socs3 is involved in negative regulation of cytokines that signal through the jak/stat pathway. inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, lif, erythropoietin, insulin, il12, gcsf and leptin receptors. binding to jak2 inhibits its kinase activity. suppresses fetal liver erythropoiesis. regulates onset and maintenance of allergic responses mediated by t-helper type 2 cells. regulates il-6 signaling in vivo (by similarity).
3617	component of a protein kinase signal transduction cascade. mediates activation of the nf-kappa-b, ap1 and ddit3 transcriptional regulators.
3618	
3619	similar to that of somatotropin.
3620	
3621	similar to that of somatotropin.
3622	associated to surface igm-receptor; may be involved in signal transduction.
3623	
3624	
3625	
3626	lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of nf-kappa-b and its transcriptional activity. induces the processing of nf-kappa-b 2/p100. could act in a receptor-selective manner (by similarity).
3627	
3628	
3629	carries out a dual function: signal transduction and activation of transcription. binds to the gas element and activates prl-induced transcription.
3630	
3631	
3632	
3633	chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. may play a role in neoplasia and inflammatory host responses. this protein can bind heparin. the processed form mcp-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of ccl7, and also of ccl2 and ccl5 and ccl8.
3634	
3635	may act as an inducible transporter in the biliary and intestinal excretion of organic anions.
3636	probably involved in the control of the cell cycle. interacts with cyclins a, b3, d, or e. activity of cdk2 is maximal during s phase and g2.
3637	type i collagen is a member of group i collagen (fibrillar forming collagen).
3638	involved in the inactivation of map kinases. dephosphorylates erk, jnk and p38 map-kinases.
3639	
3640	monokine with inflammatory and chemokinetic properties. binds to ccr5. one of the major hiv-suppressive factors produced by cd8+ t-cells. recombinant mip-1-beta induces a dose-dependent inhibition of different strains of hiv-1, hiv-2, and simian immunodeficiency virus (siv). the processed form mip-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor ccr5 and to inhibit the ccr5- mediated entry of hiv-1 in t-cells. mip-1-beta(3-69) is also a ligand for ccr1 and ccr2 isoform b.
3641	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
3642	
3643	active toward esters of long-chain and very-long chain fatty acids such as palmitoyl-coa and stearoyl-coa.
3644	has an atp-independent isopeptidase activity, cleaving at the c-terminus of the ubiquitin moiety. in vitro, isoform 2, but not isoform 3, shows deubiquitinating activity.
3645	
3646	nuclear hormone receptor. high affinity receptor for triiodothyronine.
3647	most effectively accelerate the intrinsic gtpase activity of ypt7. it is also active, but to a lesser extent, on ypt31, ypt32 and ypt1. ypt6 and sec4.
3648	acts as a coactivator in the regulation of translation initiation of poly(a)-containing mrnas. its stimulatory activity on translation is mediated via its action on pabpc1. competes with paip2 for binding to pabpc1. its association with eif4a and pabpc1 may potentiate contacts between mrna termini. may also be involved in translationally coupled mrna turnover. implicated with other rna-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding-region determinant of instability (mcrd) domain.
3649	
3650	
3651	required maternally for proper expression of other homeotic genes involved in pattern formation, such as ubx.
3652	collagen type iv is specific for basement membranes. vital for embryonic development.
3653	calcium-permeable, non-selective cation channel with an outward rectification. seems to be regulated, at least in part, by igf-i, pdgf and neuropeptide head activator. may transduce physical stimuli in mast cells. activated by temperatures higher than 52 degrees celsius; is not activated by vanilloids and acidic ph.
3654	
3655	
3656	
3657	may play a role in vesicle trafficking.
3658	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.
3659	
3660	part of the signal peptidase complex (spc), exact function is not known (by similarity).
3661	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
3662	may function as a transcription factor. seems to repress transcription.
3663	
3664	the classic group of mbp isoforms (isoform 4-isoform 14) are with plp the most abundant protein components of the myelin membrane in the cns. they have a role in both its formation and stabilization. the smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. the non- classic group of mbp isoforms (isoform 1-isoform 3/golli-mbps) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in t- cells and neural cells. differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.
3665	
3666	tumor suppressor. it blocks the growth, invasion, and metastatic properties of mammary tumors. as it does not undergo the s (stressed) to r (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
3667	suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. regulates cell death by controlling the mitochondrial membrane permeability. appears to function in a feedback loop system with caspases. inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1).
3668	involved in innate immune defense against viruses. upon interaction with intracellular dsrna produced during viral replication, triggers a transduction cascade involving mavs, which results in the activation of nf-kappa-b, irf3 and irf7 and the induction of the expression of antiviral cytokines such as ifn- beta and rantes (ccl5). essential for the production of interferons in response to rna viruses including paramyxoviruses, influenza viruses and japanese encephalitis virus (by similarity).
3669	
3670	
3671	the intermediate chains seem to help dynein bind to dynactin 150 kda component.
3672	
3673	
3674	component of the very low density lipoprotein (vldl) fraction in plasma, and is an activator of several triacylglycerol lipases. the association of apoc2 with plasma chylomicrons, vldl, and hdl is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.
3675	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
3676	
3677	
3678	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
3679	may function as a signal transducer between specific cell types of mesodermal origin.
3680	binds to scaffold/matrix attachment region (s/mar) dna and forms a molecular assembly point to allow the formation of a @#$%&transcriptosomal@#$%& complex (consisting of sr proteins and rna polymerase ii) coupling transcription and rna processing (by similarity). can function as an estrogen receptor corepressor and can also bind to the hsp27 promoter and decrease its transcription. can inhibit cell proliferation.
3681	calcium-dependent mitochondrial solute carrier (by similarity).
3682	
3683	binds avidly to the au-rich element in fos and il3/interleukin-3 mrnas. in the case of the fos au-rich element, hur binds to a core element of 27 nucleotides that contain auuua, auuuua, and auuuuua motifs.
3684	receptor for class i mhc antigens. recognizes a broad spectrum of hla-a, hla-b, hla-c and hla-g alleles. involved in the down-regulation of the immune response and the development of tolerance. competes with cd8a for binding to class i mhc antigens. inhibits fcgr1a-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
3685	type i collagen is a member of group i collagen (fibrillar forming collagen).
3686	catalyzes the conversion of 3-methylglutaconyl-coa to 3- hydroxy-3-methylglutaryl-coa. has very low enoyl-coa hydratase activity. was originally identified as rna-binding protein that binds in vitro to clustered 5@#$%&-auuua-3@#$%& motifs.
3687	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
3688	calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. receptor propably implicated in the regulation of exocytosis (by similarity).
3689	
3690	
3691	induces sprouting in endothelial cells through an autocrine and paracrine action.
3692	
3693	upon binding to egf receptor enhances egf-dependent mitogenic signals. can bind multiple cellular targets.
3694	
3695	plays a general role in the hierarchies of gene expression leading to metamorphosis.
3696	catalytic subunit of the peripheral v1 complex of vacuolar atpase. v-atpase vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
3697	
3698	
3699	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
3700	may play a role in both peripheral and central nervous system development (by similarity).
3701	
3702	
3703	may be involved in control of cell shape.
3704	
3705	the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the er, via the golgi up to the trans golgi network. coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-er transport of dilysine-tagged proteins. in mammals, the coatomer can only be recruited by membranes associated to adp-ribosylation factors (arfs), which are small gtp-binding proteins; the complex also influences the golgi structural integrity, as well as the processing, activity, and endocytic recycling of ldl receptors (by similarity).
3706	may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. when overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor (n-linked stearoyl- (c18) ceramide) in a fumonisin b1-independent manner (by similarity).
3707	
3708	
3709	binding protein for activin and bmp-2 (by similarity).
3710	
3711	essential for the control of the cell cycle at the g1/s (start) transition.
3712	
3713	circadian regulator that may act as a transcription factor. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition. expression oscillates with a 24 hour rhythm in the suprachiasmatic nucleus (scn) and the whole eyes. oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. there is a 4 hour time delay between per1 and per2 oscillations. the expression rhythms appear to originate from retina (by similarity).
3714	
3715	
3716	probable atpase involved in the assembly or function of nuclear protein complexes. may also be involved in some aspects of microtubule dynamics (by similarity).
3717	
3718	
3719	apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. acts as an inhibitor of tnfrsf6 mediated apoptosis. a proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (disc) thereby blocking further recruitment and processing of caspase-8 at the complex. full length and shorter isoforms have been shown either to induce apoptosis or to reduce tnfrsf-triggered apoptosis. lacks enzymatic (caspase) activity.
3720	isoform c is proteolytically inactive.
3721	
3722	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
3723	
3724	
3725	
3726	
3727	catalyzes the production of gaba.
3728	
3729	participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development.
3730	
3731	
3732	major protein kinase c substrate of platelets, its exact function is not known.
3733	protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton. promotes formation of stress fibers and of focal adhesion complexes. plays a role in smooth muscle contraction (by similarity).
3734	required for autophagy.
3735	
3736	
3737	
3738	
3739	acts as a regulatory subunit of the 26 proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
3740	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. associates with polr2g.
3741	this is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.
3742	acts as a transcriptional repressor for zinc finger transcription factors egr1 and egr2 (by similarity).
3743	
3744	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters.
3745	cell surface proteoglycan that bears heparan sulfate.
3746	may be involved in regulating membrane traffic to and from trans-golgi network.
3747	
3748	antimicrobial protein that kills intracellular pathogens. active against a broad range of microbes, including gram-positive and gram-negative bacteria, fungi, and parasites. kills mycobacterium tuberculosis.
3749	
3750	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. rna polymerase i is essentially used to transcribe ribosomal dna units.
3751	
3752	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation via its interaction with the myocyte enhancer factors such as mef2a, mef2c and mef2d.
3753	
3754	
3755	plays a key role in retinoic acid metabolism. acts on retinoids, including all-trans-retinoic acid (ra) and its stereoisomer 9-cis-ra. capable of both 4-hydroxylation and 18- hydroxylation. responsible for generation of several hydroxylated forms of ra, including 4-oh-ra, 4-oxo-ra and 18-oh-ra.
3756	integrin alpha-6/beta-1 is a receptor for laminin on platelets. integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
3757	transcription factor involved in the induction of oxygen regulated genes. binds to core dna sequence 5@#$%&-[ag]cgtg-3@#$%& within the hypoxia response element (hre) of target gene promoters. regulates the vascular endothelial growth factor (vegf) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. may also play a role in the formation of the endothelium that gives rise to the blood brain barrier. potent activator of the tie-2 tyrosine kinase expression. activation seems to require recruitment of transcriptional coactivators such as crebpb and probably ep300. interaction with redox regulatory protein apex seems to activate ctad.
3758	may function as signaling molecule. isoform 2 may be involved in cell growth and tumorigenesis.
3759	
3760	
3761	
3762	
3763	
3764	
3765	involved in the de novo synthesis of guanine nucleotides which are not only essential for dna and rna synthesis, but also provide gtp, which is involved in a number of cellular processes important for cell division.
3766	
3767	effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. focal adhesion protein part of the complex ilk-pinch. this complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway.
3768	gtpase-activating protein (gap) for the adp ribosylation factor 1 (arf1). involved in membrane trafficking and /or vesicle transport. promotes hydrolysis of the arf1-bound gtp and thus, is required for the dissociation of coat proteins from golgi-derived membranes and vesicles, a prerequisite for vesicle@#$%&s fusion with target compartment. probably regulates arf1-mediated transport via its interaction with the kdelr proteins and rnp24. overexpression induces the redistribution of the entire golgi complex to the endoplasmic reticulum, as when arf1 is deactivated. its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (by similarity).
3769	
3770	may play a role in the molecular organization of synapses and neuronal cell signaling. could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. may induce enrichment of psd-95/sap90 at the plasma membrane.
3771	plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity.
3772	polycomb group (pcg) protein. pcg proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. participates to the etv6-mediated repression. probably plays a role in cell proliferation. overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
3773	neutrophil and pancreatic elastase-specific inhibitor of skin. it may prevent elastase-mediated tissue proteolysis.
3774	
3775	may have a role in the regulation of spermatogenesis.
3776	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
3777	may be involved in transcriptional regulation.
3778	
3779	
3780	this is the smallest of the 5 chains of the enzymatic component (coupling factor cf(1)) of the mitochondrial atpase complex (by similarity).
3781	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters. it binds to a tax-responsive enhancer element in the long terminal repeat of htlv-i.
3782	
3783	may be involved in cell-surface proteolysis, cell adhesion or intracellular protein maturation.
3784	
3785	t-snare involved in the molecular regulation of neurotransmitter release. may play an important role in the synaptic function of specific neuronal systems. associates with proteins involved in vesicle docking and membrane fusion.
3786	ligand for multiple notch receptors and involved in the mediation of notch signaling. may be involved in cell-fate decisions during hematopoiesis. seems to be involved in early and late stages of mammalian cardiovascular development. inhibits myoblast differentiation (by similarity). enhances fibroblast growth factor-induced angiogenesis (in vitro).
3787	
3788	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
3789	the gins complex plays an essential role in the initiation of dna replication (by similarity).
3790	calretinin is a calcium-binding protein which is abundant in auditory neurons.
3791	
3792	
3793	may regulate transcriptional activity.
3794	modulates transcriptional activation by steroid receptors such as nr3c1, nr3c2 and esr1. also modulates transcriptional repression by nuclear hormone receptors.
3795	
3796	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (by similarity). has angiogenic inhibitor activity. active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture.
3797	transcriptional regulator that acts as repressor or activator. binds, in-vitro, to nf-e2 binding sites. play important roles in coordinating transcription activation and repression by mafk.
3798	
3799	
3800	
3801	editing of the messenger rnas for glutamate receptor (glur) subunits by site-selective adenosine deamination. edits both the glur-b q/r and r/g sites efficiently but converts the adenosine in hotspot1 much less efficiently.
3802	endostatin potently inhibits endothelial cell proliferation and angiogenesis. may inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
3803	collagen vi acts as a cell-binding protein.
3804	probably methylates the guanidino nitrogens of arginyl residues in some proteins. may play a role in transcriptional coactivation.
3805	probably methylates the guanidino nitrogens of arginyl residues in some proteins. may play a role in transcriptional coactivation.
3806	
3807	
3808	required for 7-methylguanosine modification of trna.
3809	
3810	inhibits the dna-binding activity of c/ebp and lap by forming heterodimers that cannot bind dna.
3811	probable transcriptional regulator involved in developmental processes. is required for normal development of the pharyngeal arch arteries (by similarity).
3812	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
3813	structural protein (cytoskeletal).
3814	
3815	displays serine/threonine-specific phosphorylation of myelin basic protein and histone (mbp) in vitro.
3816	
3817	
3818	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l (by similarity).
3819	
3820	component of the scf (skp1-cul1-f-box protein) and the cbc(vhl) (cul2-elonging bc-vhl) e3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. through the ring-type zinc finger, seems to recruit the e2 ubiquitination enzyme, like cdc34, to the complex and brings it into close proximity to the substrate. probably also stimulates cdc34 autoubiquitination. promotes the neddylation of cul1 and probably cul2.
3821	
3822	involved in the synthesis of the gdp-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (by similarity).
3823	
3824	
3825	
3826	incorporated into fibronectin-containing matrix fibers. may play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ecm). could be important for certain developmental processes and contribute to the supramolecular organization of ecm architecture, in particular to those of basement membranes. has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. may play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. could play a significant role in modulating the neurotrophic activities of app, particularly soluble app.
3827	
3828	suppresses neurite outgrowth (by similarity).
3829	may be a transporter. may act as a non-selective neuronal cation channel.
3830	probably involved in nervous system development and function.
3831	
3832	recruits tfiih to the initiation complex and stimulates the rna polymerase ii c-terminal domain kinase and dna-dependent atpase activities of tfiih. both tfiih and tfiie are required for promoter clearance by rna polymerase.
3833	
3834	
3835	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
3836	
3837	
3838	receptor for angiotensin ii. mediates its action by association with g proteins that activate a phosphatidylinositol- calcium second messenger system.
3839	
3840	connects cell membrane constituents to the actin cytoskeleton. may promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. anchors various transmembrane proteins to the actin cytoskeleton. interaction with flna may allow neuroblast migration from the ventricular zone into the cortical plate. various interactions and localizations of isoforms affect myotube morphology and myogenesis. isoform 6 accelerates muscle differentiation in vitro.
3841	
3842	forms hydroxylysine residues in -xaa-lys-gly- sequences in collagens. these hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen crosslinks.
3843	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters.
3844	
3845	
3846	catalytic subunit of the peripheral v1 complex of vacuolar atpase. v-atpase vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
3847	
3848	
3849	component of a putative tumor-recognition complex. involved in the function of nk cells.
3850	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
3851	involved in iron cellular uptake. seems to be internalized and then recycled back to the cell membrane. binds a single atom of iron per subunit. could also bind zinc.
3852	
3853	activates ubiquitin by first adenylating with atp its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in e1, yielding an ubiquitin-e1 thioester and free amp.
3854	
3855	rna-binding protein, which is essential for gametogenesis. plays a central role during spermatogenesis. may act by binding to the 3@#$%&utr of mrna and thereby regulating the translation of key transcripts (by similarity).
3856	catalyzes the initial reaction in o-linked oligosaccharide biosynthesis, the transfer of an n-acetyl-d- galactosamine residue to a serine or threonine residue on the protein receptor. although it displays a much weaker activity toward all substrates tested compared to galnt2, it is able to transfer up to seven galnac residues to the muc5ac peptide, suggesting that it can fill vicinal thr/ser residues incorporation with other galnt proteins. prefers muc1a as substrate.
3857	nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity (by similarity).
3858	in peripheral tissues, the h1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
3859	
3860	
3861	the long isoform may play a role in neural and glial cell adhesion in the developing embryo. the short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. vital for embryonic development. essential for septate junctions. septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. required for the blood-brain barrier formation.
3862	
3863	
3864	
3865	type i collagen is a member of group i collagen (fibrillar forming collagen).
3866	
3867	receptor for the mcp-1, mcp-3 and mcp-4 chemokines. transduces a signal by increasing the intracellular calcium ions level. alternative coreceptor with cd4 for hiv-1 infection.
3868	
3869	
3870	may function as a phosphatase involved in the regulation of cell growth and differentiation.
3871	
3872	
3873	
3874	
3875	transferrins are iron binding transport proteins which can bind two fe(3+) ions in association with the binding of an anion, usually bicarbonate. it is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. serum transferrin may also have a further role in stimulating cell proliferation.
3876	mediates the association of the molecular chaperones hsc70 and hsp90 (hspca and hspcb).
3877	
3878	required for the fusion of plasma membranes and early endosomes.
3879	
3880	
3881	cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. endosomal acidification leads to iron release. the apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral ph and the concomitant loss of affinity of apotransferrin for its receptor. transferrin receptor is necessary for development of erythrocytes and the nervous system (by similarity). a second ligand, the heditary hemochromatosis protein hfe, competes for binding with transferrin for an overlapping c-terminal binding site.
3882	sequence-specific rna-binding protein which participates in the control of pre-mrna splicing.
3883	may have a role in regulating spermiogenesis.
3884	actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells.
3885	may modulate the action of some growth factors on cell proliferation and differentiation. binds heparin (by similarity).
3886	e3 ubiquitin-protein ligase which accepts ubiquitin from specific e2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. negatively regulates tcr (t-cell receptor), bcr (b- cell receptor) and fcer1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. in naive t-cells, inhibits vav1 activation upon tcr engagement and imposes a requirement for cd28 costimulation for proliferation and il-2 production. also acts by promoting pik3r1/p85 ubiquitination, which impairs its recruitment to the tcr and subsequent activation. in activated t- cells, inhibits plcg1 activation and calcium mobilization upon restimulation and promotes anergy. in b-cells, acts by ubiquitinating syk and promoting its proteasomal degradation. may also be involved in egfr ubiquitination and internalization.
3887	
3888	
3889	
3890	this oncogene is expressed in neonatal brain. fgf-5 can transform nih 3t3 cells.
3891	may be involved in the control of cell growth and differenciation. may contribute to cancer.
3892	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
3893	transcriptional modulator activated by bmp (bone morphogenetic proteins) type 1 receptor kinase. smad1 is a receptor-regulated smad (r-smad).
3894	
3895	
3896	
3897	binds rnas containing the 14 base g-rich element.
3898	
3899	udpgt is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
3900	induces disassembly of actin filaments in conjunction with adf/cofilin family proteins (by similarity).
3901	functions as a sorting receptor in the golgi compartment and as a clearance receptor on the cell surface. required for protein transport from the golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (m6pr). also required for protein transport from the golgi apparatus to the endosomes. promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of bdnf (probdnf) and ngfb (prongfb). also acts as a receptor for neurotensin. may promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular lpl. probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter slc2a4/glut4 (glut4 storage vesicles, or gsvs). these vesicles provide a stable pool of slc2a4 and confer increased responsiveness to insulin. may also mediate transport from the endoplasmic reticulum to the golgi.
3902	segment polarity protein, functions together with arm to transduce the wingless (wg) signal. acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
3903	inactivation of prostaglandins.
3904	
3905	
3906	
3907	
3908	involved in regulation of actin cytoskeleton organization and endocytosis.
3909	inactivates paf by removing the acetyl group at the sn-2 position. this is a catalytic subunit. plays an important role during the development of brain.
3910	may contribute to the alteration of neural cellular mechanisms (by similarity).
3911	binds with high affinity to rna molecules that contain au-rich elements (ares) found within the 3@#$%& untranslated regions of many protooncogenes and cytokine mrnas. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain (by similarity).
3912	probable helicase involved in mitochondrial functions. required for rapid turnover of mrnas containing a premature translational termination codon.
3913	
3914	
3915	
3916	
3917	
3918	probable atp-dependent dna helicase.
3919	
3920	
3921	
3922	the heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.
3923	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
3924	
3925	receptor for vegfc. has a tyrosine-protein kinase activity.
3926	may act as positive axonal guidance cues.
3927	actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. may be down-regulated in neuroblastoma tumors.
3928	this protein promotes the gtp-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome (by similarity).
3929	
3930	general transcription factor. btf3 can form a stable complex with rna polymerase ii. required for the initiation of transcription.
3931	
3932	
3933	involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. substrates include pomc, renin, enkephalin, dynorphin, somatostatin and insulin.
3934	specific inhibition of calpain (calcium-dependent cysteine protease). plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
3935	
3936	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling. phosphorylates ctnnb1 on ser-45.
3937	high affinity receptor for activated thrombin coupled to g proteins that stimulate phosphoinositide hydrolysis. may play a role in platelets activation and in vascular development.
3938	major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle.
3939	
3940	may be required for neuronal cell differentiation.
3941	plays a role in the physiological regulation of the intracellular coa concentration (by similarity).
3942	
3943	
3944	
3945	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. this subunit, together with cytochrome b, binds to ubiquinone.
3946	likely involved in the mobilization of calcium as a result of the tcr/cd3 complex interaction. binds to cyclophilin b.
3947	not chemotactive for t-cells, b-cells, monocytes, natural killer cells or ghranulocytes. does not inhibit proliferation of myeloid progenitors in colony formation assays.
3948	
3949	
3950	regulates intra- and extracellular levels of inorganic pyrophosphate (ppi), probably functioning as ppi transporter.
3951	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
3952	c7 is a constituent of the membrane attack complex. c7 binds to c5b forming the c5b-7 complex, where it serves as a membrane anchor.
3953	
3954	
3955	
3956	
3957	
3958	associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. it may function in the assembly and/or transport of ribosome.
3959	
3960	receptor for glucocorticoids (gc). has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (gre) and as a modulator of other transcription factors. affects inflammatory responses, cellular proliferation and differentiation in target tissues. could act as a coactivator for stat5-dependent transcription upon growth hormone (gh) stimulation and could reveal an essential role of hepatic gr in the control of body growth.
3961	transcriptional regulator. recognizes and binds to the dna sequence 5@#$%&-cgcccccgc-3@#$%&(egr-site). activates the transcription of target genes whose products are required for mitogenesis and differentiation.
3962	catalyzes the s-methylation of thiopurine drugs such as 6-mercaptopurine.
3963	plus end-directed microtubule-dependent motor protein involved in mannnose-6-phosphate receptor (m6pr) transport to the plasma membrane (by similarity).
3964	
3965	
3966	
3967	
3968	type xii collagen interacts with type i collagen- containing fibrils, the col1 domain could be associated with the surface of the fibrils, and the col2 and nc3 domains may be localized in the perifibrillar matrix (by similarity).
3969	protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function.
3970	catalyzes the covalent attachment of ubiquitin to other proteins. seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum.
3971	involved in cannabinoid-induced cns effects. acts by inhibiting adenylate cyclase. could be a receptor for anandamide. isoform 2 and isoform 3 have altered ligand binding.
3972	
3973	marcks is the most prominent cellular substrate for protein kinase c. this protein binds calmodulin, actin, and synapsin. marcks is a filamentous (f) actin cross-linking protein.
3974	
3975	
3976	
3977	
3978	microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
3979	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
3980	regulates the activity of the neutrophil proteases elastase, cathepsin g and proteinase-3.
3981	transcriptional activator. binds to the interferon- stimulated response element (isre) of the mhc class i promoter. binds the immunoglobulin lambda light chain enhancer, together with pu.1. probably plays a role in isre-targeted signal transduction mechanisms specific to lymphoid cells.
3982	
3983	catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to s-lactoylglutathione.
3984	stimulates the transcription of various genes by recognizing and binding to a ccaat motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
3985	may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. it is essential for disk morphogenesis.
3986	
3987	histone h4, along with histone h3, plays a central role in nucleosome formation.
3988	component of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends.
3989	may act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
3990	may play a role in macrophage activation and function.
3991	located at the top of the head of the 40s subunit, it contacts several helices of the 18s rrna (by similarity).
3992	
3993	probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. is not an essential protein. involved in substrate recognition in ubiquitin-dependent degradation.
3994	transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.
3995	this protein specifically binds to the dna sequence 5@#$%&- gggactttcc-3@#$%& which is found in the enhancer elements of numerous viral promoters such as those of sv40, cmv, or hiv1. in addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class i mhc, interleukin-2 receptor, somatostatin receptor ii, and interferon- beta genes. it may act in t-cell activation.
3996	may be involved in several stages of intracellular trafficking.
3997	component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnrnp). hnrnp play an important role in processing of precursor mrna in the nucleus.
3998	endothelins are endothelium-derived vasoconstrictor peptides.
3999	
4000	
4001	mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons uaa and uag (by similarity).
4002	anchoring protein that mediates the subcellular compartmentation of protein kinase a (pka) and protein kinase c (pkc).
4003	
4004	
4005	
4006	
4007	interferes with the binding of transcription factors hif-1a and stat2 to p300/cbp.
4008	required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.
4009	
4010	
4011	
4012	
4013	catalyzes the formation of an hydroxyacyl-coa by addition of water on enoyl-coa. also exhibits 3-hydroxyacyl-coa epimerase and 3-hydroxyacyl-coa dehydrogenase activities. involved in the aerobic and anaerobic degradation of long-chain fatty acids.
4014	functions as an antiadhesin that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion.
4015	
4016	
4017	catalyzes the covalent attachment of ubiquitin to other proteins. capable, in vitro, to ubiquitinate histone h2a.
4018	
4019	
4020	
4021	
4022	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
4023	this enzyme is required for electron transfer from nadp to cytochrome p450 in microsomes. it can also provide electron transfer to heme oxygenase and cytochrome b5. may function to clear the olfactory organ (antennae) from accumulating chemicals.
4024	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
4025	
4026	
4027	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
4028	tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
4029	may be a controller of the mitotic cell cycle. involved in the blood cell development.
4030	required for vacuolar assembly and vacuolar traffic.
4031	
4032	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
4033	
4034	isoform b has an accelerated gef-independent gdp/gtp exchange and an impaired gtp hydrolysis, which is restored partially by gtpase-activating proteins. it is able to bind to the gtpase-binding domain of pak but not full-length pak in a gtp- dependent manner, suggesting that the insertion does not completely abolish effector interaction.
4035	
4036	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
4037	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
4038	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
4039	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
4040	
4041	guanine nucleotide exchange factor (gef) for rap1a, rap2a and mras/m-ras-gtp. its association with mras inhibits rap1 activation.
4042	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
4043	
4044	has very limited arylesterase and no paraoxonase activities but rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (by similarity).
4045	ligand-activated transcriptional activator. binds to the xre promoter region of genes it activates. activates the expression of multiple phase i and ii xenobiotic chemical metabolizing enzyme genes (such as the cyp1a1 gene). mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. involved in cell-cycle regulation. likely to play an important role in the development and maturation of many tissues.
4046	phosphorylates rs domain-containing proteins, such as sfrs1 and sfrs2 on serine residues. role in spliceosome assembly and in mediating the trafficking of splicing factors. appears to mediate hbv core protein phosphorylation which is a prerequisite for pregenomic rna encapsidation into viral capsids.
4047	
4048	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
4049	
4050	
4051	
4052	transcription factor, master regulator of tracheal cell fates in the embryo, necessary for the development of the salivary gland duct and the posterior spiracles. it may induce a general fate of branched tubular structures of epithelial origin. heterodimers of tgo/trh are involved in the control of breathless expression.
4053	involved in the transport of chloride ions. may regulate bicarbonate secretion and salvage in epithelial cells by regulating the slc4a7 transporter.
4054	
4055	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. this is a component of the iron-sulfur (ip) fragment of the enzyme.
4056	transcriptional repressor that binds to the promoter region of target genes. plays a role in the regulation of the cell cycle and of the wnt pathway. binds preferentially to the sequence 5@#$%&-ttcattcattca-3@#$%&. binding to the h1f0 promoter is enhanced by interaction with rb1. disrupts the interaction between dna and tcf4.
4057	may be involved in transcriptional regulation.
4058	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex.
4059	required for ribosomal rna processing. associates with u3 small nucleolar rna.
4060	mediates ubiquitination of cellular proteins.
4061	
4062	not yet clear. it is known to be expressed in a variety of tissues and it seems to be able to bind to cells, membranes and hydrophobic proteins. it has been associated with programmed cell death (apoptosis).
4063	
4064	
4065	participates in the regulation of gene transcription. binds dna both in a non-specific manner and also specifically to recognizes the core sequence 5@#$%&-cac[ga]tg-3@#$%&. seems to activate the transcription of growth-related genes.
4066	
4067	preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone.
4068	binds and activates tie2 receptor by inducing its tyrosine phosphorylation. implicated in endothelial developmental processes later and distinct from that of vegf. appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. mediates blood vessel maturation/stability. it may play an important role in the heart early development.
4069	
4070	redirects newly synthesized mhc class i heavy chains via the sec61 translocon to the cytosol where they undergo proteasome- dependent destruction. in consequence, infected cells are masked for immune recognition by cytotoxic t-lymphocytes.
4071	
4072	
4073	
4074	specifically hydroxylates an asp or asn residue in certain epidermal growth factor-like (egf) domains of a number of proteins.
4075	
4076	binds the telomeric double-stranded ttaggg repeat and negatively regulates telomere length. involved in the regulation of the mitotic spindle.
4077	endopeptidase that degrades various components of the extracellular matrix, such as collagen type iii and fibronectin. activates progelatinase a. involved in the matrix remodeling of blood vessels. the short isoform cleaves fibronectin and also collagen type iii, but at lower rate. it has no effect on type i, ii, iv and v collagen. however, upon interaction with cspg4, it may be involved in degradation and invasion of type i collagen by melanoma cells.
4078	promotes guanine-nucleotide exchange on arf1 and arf5. promotes the activation of arf through replacement of gdp with gtp.
4079	membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. two types of receptor subunits exist. these receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (ldl).
4080	
4081	
4082	promote mitochondrial fission (by similarity).
4083	probable transcription factor involved in muscle spindle development.
4084	may play a role in developmental myelination of peripheral nerves.
4085	
4086	ubiquitous transcription factor required for a diverse set of processes. it is a component of the ccr4 complex involved in the control of gene expression (by similarity).
4087	hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
4088	adapter protein, which negatively regulates t-cell receptor (tcr) signaling. inhibits t-cell antigen-receptor induced activation of nuclear factor of activated t-cells. involved in the negative regulation of positive selection and mitosis of t-cells. may act by linking signaling proteins such as zap70 with cbl, leading to a cbl dependent degradation of signaling proteins.
4089	plays an adhesive role by integrating collagen bundles. it is probably associated with the surface of interstitial collagen fibrils via col1. the col2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large n-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (by similarity).
4090	belongs to the exosome, a rna-processing complex, which is at least involved in the 3@#$%& processing of the 7s pre-rrna to the mature 5.8s rrna. exhibits a 3@#$%&-5@#$%& exoribonuclease activity (by similarity).
4091	probable transcription regulator.
4092	
4093	may be involved in collagen fiber assembly (by similarity).
4094	may play a role in germ line formation.
4095	recognizes and binds the palindromic sequence 5@#$%&- ttggcnnnnngccaa-3@#$%& present in viral and cellular promoters and in the origin of replication of adenovirus type 2. these proteins are individually capable of activating transcription and replication.
4096	transports l-glutamate and also l- and d-aspartate. essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. acts as a symport by cotransporting sodium. negatively regulated by arl6ip5 (by similarity).
4097	regulates and initiates biosynthesis of n- acetylneuraminic acid (neuac), a precursor of sialic acids. plays an essential role in early development (by similarity). required for normal sialylation in hematopoietic cells. sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.
4098	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
4099	
4100	
4101	
4102	
4103	
4104	
4105	inhibits the transcriptional activity of spi1 in a dose- dependent manner (by similarity).
4106	probable transcription factor. could be involved in thyroid gland organogenesis.
4107	
4108	
4109	
4110	receptor for brain-derived neurotrophic factor (bdnf), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (ngf). involved in the development and/or maintenance of the nervous system. this is a tyrosine-protein kinase receptor. known substrates for the trk receptors are shc1, pi-3 kinase, and plc- gamma-1.
4111	
4112	may play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
4113	adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. mediates activation of nf-kappa-b and jnk and is involved in apoptosis. the traf1/traf2 complex recruits the apoptotic suppressors birc2 and birc3 to tnfrsf1b/tnfr2.
4114	may be involved in vesicular trafficking and neurotransmitter release.
4115	
4116	multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. isoform 2 anti-apoptotic activity is mediated by inhibition of the gzma- activated dnase, nme1. in the course of cytotoxic t-lymphocyte (ctl)-induced apoptosis, gzma cleaves set, disrupting its binding to nme1 and releasing nme1 inhibition. isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2a. isoform 1 and isoform 2 inhibit ep300/crebbp and pcaf-mediated acetylation of histones (hat) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. the predominant target for inhibition is histone h4. hat inhibition leads to silencing of hat-dependent transcription and prevents active demethylation of dna. both isoforms stimulate dna replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.
4117	neuronal calcium sensor, regulator of g protein-coupled receptor phosphorylation in a calcium dependent manner. directly regulates grk1 (rhok), but not grk2 to grk5. can substitute for calmodulin (by similarity).
4118	catalyzes the atp-dependent amination of utp to ctp with either l-glutamine or ammonia as the source of nitrogen.
4119	this small ubiquitous enzyme is essential for maintenance and cell growth.
4120	
4121	involved in low-affinity copper uptake (potential).
4122	histone methyltransferase. methylates lys-9 of histone h3 (in vitro). h3 lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting hp1 proteins to methylated histones. probably targeted to histone h3 by different dna-binding proteins like e2f6, mga, max and/or dp1. during g0 phase, it probably contributes to silencing of myc- and e2f-responsive genes, suggesting a role in g0/g1 transition in cell cycle.
4123	
4124	
4125	
4126	
4127	binds preferentially single-stranded dna and unwinds double stranded dna (by similarity).
4128	critical component of the membrane-bound oxidase of phagocytes that generates superoxide. it is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic nadph across the plasma membrane to molecular oxygen on the exterior. also functions as a voltage-gated proton channel that mediates the h(+) currents of resting phagocytes. it participates in the regulation of cellular ph and is blocked by zinc.
4129	
4130	
4131	
4132	probably involved in nervous system development and function.
4133	may have an involvement in muscle development or hypertrophy.
4134	
4135	
4136	
4137	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
4138	may function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. may therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin.
4139	gtpase activator for the rho-type gtpases by converting them to an inactive gdp-bound state. could regulate the interactions of signaling molecules with the actin cytoskeleton. promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.
4140	this is the non-catalytic component of a yet unknown sodium or proton exchange atpase.
4141	implicated in tumor cell metastasis. may function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction.
4142	required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
4143	motor protein that translocates prc1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. may play a role in mitotic chromosomal positioning and bipolar spindle stabilization.
4144	
4145	involved in t-cell adhesion processes. it is involved in spontaneous rosette formation with erythrocytes.
4146	
4147	
4148	
4149	
4150	
4151	mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. also required for the transfer of beta-barrel precursors from the tom complex to the sorting and assembly machinery (sam complex) of the outer membrane. acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. the timm8-timm13 complex mediates the import of proteins such as timm23, slc25a12/aralar1 and slc25a13/aralar2, while the predominant timm9-timm10 70 kda complex mediates the import of much more proteins. probably necessary for normal neurologic development.
4152	plays a role in modulation of e3 ubiquitin ligase activity of the 2 subunit brca1/bard1 complex.
4153	
4154	protects t-cells from il2 deprivation-induced apoptosis through the inhibition of foxo3a transcriptional activity that leads to the down-regulation of the pro-apoptotic factor bcl2l11. in macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and il10. in t-cells, inhibits anti-cd3-induced nfkb1 nuclear translocation. in vitro, suppresses ap1 and nfkb1 dna-binding activities (by similarity).
4155	self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
4156	may supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-golgi network. under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
4157	
4158	part of the snapc complex required for the transcription of both rna polymerase ii and iii small-nuclear rna genes. binds to the proximal sequence element (pse), a non-tata-box basal promoter element common to these 2 types of genes. recruits tbp and brf2 to the u6 snrna tata box.
4159	may be involved in chromatin remodeling and transcriptional regulation. may have a role in x inactivation.
4160	
4161	probable atp-dependent rna helicase. may play a role in spermatogenesis.
4162	
4163	
4164	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to g(i)-alpha and g(o)-alpha, but not to g(s)-alpha. may play a role in regulating the kinetics of signaling in the phototransduction cascade.
4165	inhibits the transcription of ribosomal rna. may inhibits the specific dna binding of ubf1.
4166	
4167	seems to plays a role in epithelial tight junction formation. appears early in primordial forms of cell junctions and recruits pard3. the association of the pard6-pard3 complex may prevent the interaction of pard3 with jam1, thereby preventing tight junction assembly (by similarity). plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. involved in platelet activation.
4168	
4169	
4170	
4171	
4172	receptor for mica, micb, ulbp1, ulbp2, ulbp3 (ulbp2>ulbp1>ulbp3) and ulbp4. plays a role as a receptor for the recognition of mhc class i hla-e molecules by nk cells and some cytotoxic t-cells. involved in the immune surveillance exerted by t- and b-lymphocytes.
4173	
4174	
4175	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (by similarity). probably encodes a dihydropyridine-insensitive current. vital for survival to adulthood.
4176	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
4177	desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
4178	
4179	initiates the extrinsic pathway of blood coagulation. serine protease that circulates in the blood in a zymogen form. factor vii is converted to factor viia by factor xa, factor xiia, factor ixa, or thrombin by minor proteolysis. in the presence of tissue factor and calcium ions, factor viia then converts factor x to factor xa by limited proteolysis. factor viia will also convert factor ix to factor ixa in the presence of tissue factor and calcium.
4180	
4181	
4182	overproduction suppresses the slow growth phenotype of cpr7 mutant cells.
4183	
4184	selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
4185	
4186	
4187	involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
4188	
4189	
4190	
4191	integrin alpha-e/beta-7 is a receptor for e-cadherin. it mediates adhesion of intra-epithelial t-lymphocytes to epithelial cell monolayers.
4192	
4193	
4194	
4195	
4196	
4197	
4198	may be involved in transcriptional regulation.
4199	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
4200	adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. alpha adaptin is a subunit of the plasma membrane adaptor. binds polyphosphoinositides (by similarity).
4201	
4202	functions as a myeloid and b-cell proto-oncogene. may play important roles in leukemogenesis and hematopoiesis. an essential factor in lymphopoiesis, is required for b-cell formation in fetal liver. may function as a modulator of the transcriptional repression activity of arp1 (by similarity).
4203	
4204	function in general translation initiation by promoting the binding of the formylmethionine-trna to ribosomes. seems to function along with eif-2 (by similarity).
4205	
4206	
4207	decoy receptor for the cytotoxic ligands tnfs14/light and tnfsf6/fasl. protects against apoptosis.
4208	
4209	acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin g. may prevent elastase-mediated damage to oral and possibly other mucosal tissues (by similarity).
4210	
4211	
4212	
4213	converts lysophosphatidic acid (lpa) into phosphatidic acid by incorporating acyl moiety at the 2 position (by similarity).
4214	plasma membrane-associated small gtpase which cycles between an active gtp-bound and inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. seems to be involved in the regulation of the nadph oxidase.
4215	plasma membrane-associated small gtpase which cycles between an active gtp-bound and inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. seems to be involved in the regulation of the nadph oxidase.
4216	rna-dependent atpase activity.
4217	
4218	
4219	could be involved in the repair of interstrand crosslinks.
4220	functions in nuclear protein import as an adapter protein for nuclear receptor kpnb1. binds specifically and directly to substrates containing either a simple or bipartite nls motif. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. in vitro, mediates the nuclear import of human cytomegalovirus ul84 by recognizing a nonclassical nls. in vitro, mediates the nuclear import of human cytomegalovirus ul84 by recognizing a nonclassical nls.
4221	
4222	
4223	
4224	
4225	the heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.
4226	
4227	
4228	probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment.
4229	calcium-binding protein required for t-cell receptor-, fas-, and glucocorticoid-induced cell death. may mediate ca(2+)- regulated signals along the death pathway (by similarity).
4230	
4231	
4232	
4233	
4234	
4235	clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
4236	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
4237	
4238	e3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. regulates apoptosis by catalyzing the polyubiquitination and degradation of mcl1. also ubiquitinates the p53 tumor suppressor and core histones including h1, h2a, h2b, h3 and h4. binds to an upstream initiator-like sequence in the preprodynorphin gene.
4239	this alpha-adrenergic receptor mediates its action by association with g proteins that activate a phosphatidylinositol- calcium second messenger system.
4240	
4241	
4242	may play a role in growth and differentiation of tissues involved in metabolic control. may play a regulatory role during g0/g1 transition of cell growth.
4243	non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via g-protein coupled receptor (gpcr) occupancy by ligands such as bombesin or lysophosphatidic acid, or via ldl receptor occupancy. plays a potential role in oncogenic transformations resulting in increased kinase activity.
4244	likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. may play a role in the differentiation of spermatozoa and oocytes.
4245	this protein participates in processes of transmission and amplification of the visual signal. necessary for the formation of a functional phosphodiesterase holoenzyme.
4246	
4247	key enzyme in the regulation of glycerol uptake and metabolism.
4248	
4249	regulates eif4e activity by preventing its assembly into the eif4f complex. mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the map kinase pathway.
4250	regulatory light chain of myosin. does not bind calcium.
4251	plays a role as a receptor for the recognition of mhc class i hla-e molecules by nk cells and some cytotoxic t-cells.
4252	
4253	could be a melanogenic enzyme. could represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. release of the soluble form, me20-s, could protect tumor cells from antibody mediated immunity.
4254	
4255	probably important in the developing nervous system.
4256	stimulates specifically the gtpase activity of ypt6.
4257	
4258	
4259	
4260	a positive regulator of the alternate pathway of complement. it binds to and stabilizes the c3- and c5-convertase enzyme complexes.
4261	
4262	
4263	
4264	
4265	involved in cytokinesis (potential).
4266	regulation of transcription.
4267	
4268	
4269	
4270	
4271	
4272	
4273	unknown.
4274	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
4275	
4276	exhibits lysophosphatidic acid acyltransferase activity (lpaat) (by similarity). may promote the activation of caspases and apoptosis.
4277	binds to activated (phosphorylated) protein-tyrosine kinases through its sh2 domain and regulates their kinase activity. during insulin stimulation, it also binds to irs-1.
4278	cleaves peptide substrates on the n-terminus of arginine residues in dibasic pairs.
4279	expressed by macrophages in acutely inflammated tissues and in chronic inflammations. seem to be an inhibitor of protein kinases. also expressed in epithelial cells constitutively or induced during dermatoses. may interact with components of the intermediate filaments in monocytes and epithelial cells.
4280	
4281	may be involved in transcriptional regulation.
4282	protein tyrosine phosphatase which stimulates progression from g1 into s phase during mitosis. promotes tumors. inhibits geranylgeranyl transferase type ii activity by blocking the association between rabggta and rabggtb.
4283	
4284	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i (by similarity).
4285	this protein is an integral component of basement membranes. it is responsible for the fixed negative electrostatic charge and is involved in the charge-selective ultrafiltration properties. it serves as an attachment substrate for cells.
4286	
4287	probable zinc protease. may mediate cell-cell or cell- matrix interactions. isoform 2 displays alpha-secretase activity for app.
4288	binds to proliferating cell nuclear antigen. might affect pcna interaction with some cdk (cell division protein kinase) complexes; stimulates dna excision repair in vitro and inhibits entry of cells into s phase.
4289	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
4290	nuclear hormone receptor. involved in the retinoic acid response pathway. binds 9-cis retinoic acid (9c-ra).
4291	seems to play a role in junctional plaques.
4292	5@#$%&->3@#$%& double-stranded dna exonuclease involved in mismatch repair and eventually also in mitotic recombination between direct repeats. also has a minor role in the correction of large dna mismatches that occur in the heteroduplex dna during meiotic recombination at the his4 locus.
4293	
4294	
4295	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
4296	
4297	may play a role in macrophage activation and function.
4298	
4299	component of heterochromatin. recognizes and binds histone h3 tails methylated at lys-9, leading to epigenetic repression. can interact with lamin b receptor (lbr). this interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. involved in the formation of functional kinetochore through interaction with mis12 complex proteins.
4300	participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. mediates rac1-dependent reorganization of actin filaments. contributes to the activation of pld2 (by similarity).
4301	
4302	
4303	
4304	
4305	
4306	
4307	
4308	
4309	transcription coregulator that can have both coactivator and corepressor functions. isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid x (rxrs) and thyroid hormone (trs) in a ligand-dependent fashion. in contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin d, progesterone receptor, glucocorticoid nor estrogen. acts as a transcriptional corepressor via its interaction with the nfkb1 nf-kappa-b subunit, possibly by interfering with the transactivation domain of nfkb1. induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. may also act as an inhibitor of cyclin a-associated kinase.
4310	may participate in the obstruction of fluid outflow in the trabecular meshwork.
4311	
4312	
4313	
4314	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
4315	component of a protein kinase signal transduction cascade. regulates the jnk and erk5 pathways by phosphorylating and activating map2k5 and map2k7. plays a role in caveolae kiss- and-run dynamics (by similarity).
4316	calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction.
4317	may be involved in transcriptional regulation.
4318	able to activate nf-kappa-b 1 by stimulating proteasome- mediated proteolysis of nf-kappa-b 1/p105. plays a role in the cell cycle. the longer form of cot has some transforming activity, although it is much weaker than the activated cot oncoprotein.
4319	
4320	
4321	
4322	catalyzes the formation of s-adenosylmethionine from methionine and atp.
4323	
4324	controls the genesis of the spleen. binds to the dna sequence 5@#$%&-ggcggtaagtgg-3@#$%&.
4325	may act as a molecular switch during maturation of the 40s ribosomal subunit in the nucleolus (by similarity).
4326	
4327	
4328	
4329	potent plasminogen activator and is clinically used for therapy of thrombolytic disorders.
4330	inhibitor of wnt signaling pathway.
4331	this is a receptor for the tachykinin neuropeptide substance k (neurokinin a). it is associated with g proteins that activate a phosphatidylinositol-calcium second messenger system.
4332	
4333	
4334	essential for the control of the cell cycle at the g2/m (mitosis) transition.
4335	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
4336	may have an important and specific function in tumor progression and embryogenesis. cleaves alpha-1-antitrypsin.
4337	may act as a gtpase activating protein for rab family protein(s).
4338	participates in the bidirectional intercellular signaling between the posterior follicle cells and oocyte to establish spatial coordinates that induces axis formation. complex with tsu is essential for cytoplasmic localization of oskar in the posterior pole of oocytes. required for the polarization of the oocyte microtubule cytoskeleton.
4339	
4340	catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (ipp) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (dmapp) (by similarity).
4341	
4342	receptor for the chemotactic and inflammatory peptide anaphylatoxin c3a. this receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
4343	may be involved in cell-cell interactions and recognition.
4344	
4345	
4346	
4347	controls reversibly actin polymerization and depolymerization in a ph-sensitive manner. it has the ability to bind g- and f-actin in a 1:1 ratio of cofilin to actin. it is the major component of intranuclear and cytoplasmic actin rods.
4348	thiol protease which is believed to participate in intracellular degradation and turnover of proteins. has also been implicated in tumor invasion and metastasis.
4349	
4350	
4351	plays a major role in ketone body metabolism.
4352	
4353	chaperone. isoform 2 may function as an endogenous inhibitory regulator of hsc70 by competing the cochaperones.
4354	
4355	
4356	may play a role in the regulation of sterol metabolism. binds a range of oxysterols.
4357	collagen type iii occurs in most soft connective tissues along with type i collagen.
4358	
4359	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
4360	
4361	troponin i is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin atpase activity.
4362	
4363	receptor for hyaluronic acid (ha). mediates cell-cell and cell-matrix interactions through its affinity for ha, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix matalloproteinases (mmps). adhesion with ha plays an important role in cell migration, tumor growth and progression. also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. altered expression or dysfunction causes numerous pathogenic phenotypes. great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
4364	receptor for atp and utp coupled to g-proteins that activate a phosphatidylinositol-calcium second messenger system. the affinity range is utp = atp > atp-gamma-s >> 2-methylthio-atp = adp.
4365	c1s b chain is a serine protease that combines with c1q and c1s to form c1, the first component of the classical pathway of the complement system. c1r activates c1s so that it can, in turn, activate c2 and c4.
4366	catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the c-terminus of several proteins having the c-terminal sequence cys-aliphatic-aliphatic-x. the alpha subunit is thought to participate in a stable complex with the substrate. the beta subunit binds the peptide substrate.
4367	
4368	
4369	
4370	probably involved in the control of the cell cycle.
4371	seems to be a intermediate filament associated protein that links endocytic vesicles to microtubules.
4372	
4373	may play a role in the assembly of ubiquitin ligase complexes and modulate the ubiquitination of target proteins. may be a transcription regulator (potential).
4374	
4375	
4376	contactins mediate cell surface interactions during nervous system development. has some neurite outgrowth-promoting activity (by similarity).
4377	dna primase is the polymerase that synthesizes small rna primers for the okazaki fragments made during discontinuous dna replication.
4378	
4379	
4380	plays a role in b-cell proliferation and differentiation. associates with cd5.
4381	
4382	
4383	
4384	acts on retinol bound on cellular retinol-binding protein (crbp).
4385	
4386	calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. may be involved in transcriptional regulation. may be involved in regulation of microtubule dynamics. in vitro, phosphorylates creb1, crebbp, prm2, mef2a, mef2d and stmn1/op18. may be involved in spermatogenesis. may play a role in the consolidation/retention of hippocampus-dependent long-term memory (by similarity).
4387	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
4388	
4389	
4390	histones h1 are necessary for the condensation of nucleosome chains into higher order structures.
4391	
4392	
4393	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
4394	
4395	stabilizer subunit of the dolichol-phosphate-mannose synthase complex.
4396	promotes angiogenesis and the proliferation of endothelial cells. able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
4397	
4398	actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia.
4399	
4400	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. this subunit is involved in antigen processing to generate class i binding peptides.
4401	
4402	protects the hemoglobin in erythrocytes from oxidative breakdown.
4403	is able to inhibit all four classes of proteinases by a unique @#$%&trapping@#$%& mechanism. this protein has a peptide stretch, called the @#$%&bait region@#$%& which contains specific cleavage sites for different proteinases. when a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. the entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
4404	controls sodium and chloride ion transport by inhibiting the activity of wnk4, potentially by either phosphorylating the kinase or via an interaction between wnk4 and the autoinhibitory domain of wnk1. wnk4 regulates the activity of the thiazide- sensitive na-cl cotransporter, slc12a3, by phosphorylation. wnk1 may also play a role in actin cytoskeletal reorganization.
4405	
4406	involved in maintaining the transcriptionally repressive state of genes. modifies chromatin, rendering it heritably changed in its expressibility (by similarity). regulator of cellular lifespan by maintaining the repression of cdkn2a, but not by inducing telomerase activity.
4407	involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-lewis x determinant. has a alpha-2,3- sialyltransferase activity toward gal-beta1,4-glcnac structure on glycoproteins and glycolipids. has a restricted substrate specificity, it utilizes gal-beta1,4-glcnac on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-gm1.
4408	
4409	stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. active in the presence of nad as cofactor but not in the presence of nadp.
4410	
4411	
4412	sulfate transporter. may play a role in endochondral bone formation.
4413	
4414	
4415	
4416	
4417	
4418	the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-coa and co(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (e1), dihydrolipoamide acetyltransferase (e2) and lipoamide dehydrogenase (e3).
4419	component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix.
4420	may play a structural role at sites of cell adhesion in maintaining cell shape and motility. in addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. may be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
4421	
4422	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
4423	
4424	plays a role in neurofilament network integrity. may be involved in modulating axonal architecture during development and in the adult. in vitro, increases the susceptibility of neurofilament-h to calcium-dependent proteases (by similarity). may also function in modulating the keratin network in skin. activates the mapk and elk-1 signal transduction pathway (by similarity).
4425	
4426	binds to and inhibits the transcriptional repressor zbtb33, which may lead to activation of target genes of the wnt signaling pathway (by similarity). may associate with and regulate the cell adhesion properties of both c- and e-cadherins. implicated both in cell transformation by src and in ligand- induced receptor signaling through the egf, pdgf, csf-1 and erbb2 receptors.
4427	
4428	
4429	essential component of the scf (skp1-cul1-f-box protein) e3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. in the scf complex, serves as a rigid scaffold that organizes the skp1-f-box protein and rbx1 subunits. may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
4430	essential component of the scf (skp1-cul1-f-box protein) e3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. in the scf complex, serves as a rigid scaffold that organizes the skp1-f-box protein and rbx1 subunits. may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
4431	
4432	
4433	
4434	c-terminal processed part of pcpe (ct-pcpe) may have an metalloproteinase inhibitory activity.
4435	
4436	
4437	stimulates specifically the gtpase activity of ypt6.
4438	
4439	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
4440	catalyzes the o-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. also shortens the biological half-lives of certain neuroactive drugs, like l-dopa, alpha-methyl dopa and isoproterenol.
4441	stimulator of protein export for nes-containing proteins. also plays a role in the nuclear export of u1 snrna, trna, and mrna (by similarity).
4442	converts specific uridines to psi in a number of trna substrates. acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing trna. involved in regulation of nuclear receptor activity possibly through pseudouridylation of sra1 rna (by similarity).
4443	cell surface proteoglycan that bears heparan sulfate. may fulfill a function related to the motile behaviors of developing neurons (by similarity).
4444	could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by ngf. may be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (by similarity).
4445	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
4446	cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (nk) cells to mediate tumor cell lysis.
4447	collagen type iv is specific for basement membranes. vital for embryonic development.
4448	collagen type iv is specific for basement membranes. vital for embryonic development.
4449	
4450	probably plays a role in anchoring the complex to other cellular components.
4451	
4452	activates apoptosis and interacts selectively with survival-promoting proteins bcl-2 and bcl-x(l).
4453	
4454	transcriptional repressor.
4455	
4456	
4457	transport of phosphate groups from the cytosol to the mitochondrial matrix. phosphate is cotransported with h(+).
4458	
4459	
4460	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
4461	activates pro-caspase-1 and pro-caspase-8. potentiates casp8-mediated apoptosis. activates nf-kappa-b.
4462	
4463	
4464	dna helicase that may play a role in the repair of dna that is damaged by ultraviolet light or other mutagens. exhibits a magnesium-dependent atp-dependent dna-helicase activity that unwinds single- and double-stranded dna in a 3@#$%&-5@#$%& direction.
4465	
4466	this enzyme is required for electron transfer from nadp to cytochrome p450 in microsomes. it can also provide electron transfer to heme oxygenase and cytochrome b5. may function to clear the olfactory organ (antennae) from accumulating chemicals.
4467	binds to the gm-csf promoter. seems to act as a repressor. binds also to full length mrna and to short rna sequences containing the consensus site 5@#$%&-uccauca-3@#$%&. may have a role in translation repression (by similarity).
4468	
4469	histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). in addition, histatins exhibit antibacterial and antifungal activities.
4470	mediates estrogen action in various target organs.
4471	id (inhibitor of dna binding) hlh proteins lack a basic dna-binding domain but are able to form heterodimers with other hlh proteins, thereby inhibiting dna binding.
4472	this is the smallest of the 5 chains of the enzymatic component (coupling factor cf(1)) of the mitochondrial atpase complex (by similarity).
4473	receptor with an affinity for galactose and fucose. could be involved in endocytosis.
4474	may modulate the functions ascribed to brca1 in transcriptional regulation, dna repair, and/or cell cycle checkpoint control.
4475	
4476	
4477	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
4478	this protein is a component of ribonucleosomes.
4479	
4480	this protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.
4481	
4482	
4483	type i collagen is a member of group i collagen (fibrillar forming collagen).
4484	involved in late endocytic transport. contributes to the maturation of phagosomes (acidification) (by similarity).
4485	
4486	enzyme involved in the biosynthesis of the e-selectin ligand, sialyl-lewis x. catalyzes the transfer of fucose from gdp- beta-fucose to alpha-2,3 sialylated substrates.
4487	
4488	
4489	
4490	
4491	
4492	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
4493	
4494	sterol sensor. necessary for the proteolytic activation of srebps by site-1 protease in the golgi.
4495	
4496	
4497	
4498	required for protein translocation and folding in the endoplasmic reticulum (er). functions as a nucleotide exchange factor for the er lumenal chaperone hspa5.
4499	not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. antigen recognized on a melanoma by autologous cytolytic t-lymphocytes.
4500	regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. the condensin complex probably introduces positive supercoils into relaxed dna in the presence of type i topoisomerases and converts nicked dna into positive knotted forms in the presence of type ii topoisomerases. may target the condensin complex to dna via its c-terminal domain.
4501	
4502	
4503	plays a central role as a glucosyl donor in cellular metabolic pathways.
4504	
4505	
4506	may function as a gtpase-activating protein and may play important roles during t-cell activation.
4507	protein kinase that act on both serine and threonine residues.
4508	
4509	promotes the exchange of cdc42-bound gdp by gtp. controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. cdc24 may be involved in the initial selection and organization of the budding site.
4510	may act as a gtpase activating protein for rab family protein(s).
4511	binds to actin and affects the structure of the cytoskeleton. at high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. by binding to pip2, it inhibits the formation of ip3 and dg.
4512	orphan receptor.
4513	nociceptin is the ligand of the opioid receptor-like receptor (oprl1). it may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. may be involved in neuronal differentiation and development (by similarity).
4514	
4515	
4516	
4517	this protein is associated with nerve growth. it is a major component of the motile @#$%!growth cones@#$%! that form the tips of elongating axons.
4518	shows activity also towards tryptophan, aspartate and hydroxykinurenine.
4519	receptor for atrial natriuretic peptide. does not have guanylate cyclase activity.
4520	receptor for atp that acts as a ligand gated ion channel. responsible for atp-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. could function in both fast synaptic transmission and the atp-mediated lysis of antigen-presenting cells.
4521	
4522	
4523	activity is required for interleukin 6 (il-6) induced differentiation. may play a role in the growth and differentiation of hematopoietic cells. may be involved in signal transduction in endocardial and arterial endothelial cells.
4524	
4525	
4526	
4527	
4528	promote mitochondrial fission (by similarity).
4529	
4530	binds to bacterial lipopolysaccharides (lps), has antibacterial activity.
4531	dna-binding protein that specifically binds heat shock promoter elements (hse) and activates transcription. in higher eukaryotes, hsf is unable to bind to the hse unless the cells are heat shocked.
4532	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
4533	
4534	
4535	
4536	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to sites in the 5@#$%&-flanking sequence of its coding region with various affinities. the consensus sequences of the high and low affinity binding sites are 5@#$%&-taatga[cg]-3@#$%& and 5@#$%&-ctaatttt- 3@#$%&.
4537	
4538	the kinesin family may recognize, transport and position their specific cargos in a single type of neuronal cell.
4539	
4540	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
4541	
4542	
4543	could be involved in oogenesis. involved in the regulation of endosome dynamics. implicated in a novel signal transduction pathway, in which isoform 3 and csk are sequentially activated by rhod to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
4544	
4545	
4546	
4547	
4548	essential subunit of n-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an asn-x-ser/thr consensus motif in nascent polypeptide chains.
4549	
4550	
4551	
4552	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
4553	
4554	
4555	
4556	
4557	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
4558	
4559	component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix.
4560	muscle contraction.
4561	cell autonomous negative regulator of lin-12/notch- mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. may function as part of an e3 complex to target the intracellular domains of lin-12/notch proteins for ubiquitin-dependent degradation.
4562	stimulates chloride conductance when expressed in cells. mediates chloride ion transport across the membrane. it may be a component or a regulator of the chloride channel. it may participate in cellular growth control.
4563	involved in axon growth. plays an essential role in neurite extension of cerebellar granule cells.
4564	probable transcription regulator.
4565	may have a function in the nucleus.
4566	
4567	destroys radicals which are normally produced within the cells and which are toxic to biological systems.
4568	plays a role in lipoprotein assembly and dietary cholesterol absorption. in addition to its acyltransferase activity, it may act as a ligase. may provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
4569	this is a carcinoma-associated protein, probably a mucin.
4570	
4571	
4572	plc-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
4573	may function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.
4574	
4575	
4576	essental for release from glucose repression. it interacts and has functional relationship to the regulatory protein snf4. interacts also with sip1, sip2 and gal83. could phosphorylates cat8.
4577	adhesion plaque protein. binds alpha-actinin and the crp protein. may be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (by similarity).
4578	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. displays glutathione peroxidase activity with cumene hydroperoxide.
4579	
4580	
4581	
4582	
4583	
4584	
4585	
4586	
4587	
4588	
4589	efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. the bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates.
4590	
4591	
4592	interacts with the internal control region (icr) of approximately 50 bases within the 5s rna genes, is required for correct transcription of these genes by rna polymerase iii. also binds the transcribed 5s rna@#$%&s. may initiate transcription of the 5s ribosomal rna gene and maintain the stability of transcription of other genes.
4593	involved in dna excision repair. may play a part in dna damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes.
4594	
4595	involved in active uptake of glycerol driven by electrogenic proton symport.
4596	
4597	amidohydrolase that hydrolyzes specifically one of the carboamide linkages in d-pantetheine thus recycling pantothenic acid (vitamin b5) and releasing cysteamine.
4598	
4599	
4600	binds to the consensus sequence 5@#$%&-aacaaag-3@#$%& and is able to trans-activate transcription via this site (by similarity).
4601	inhibitory regulator of the ras-cyclic amp pathway. stimulates the gtpase of normal but not oncogenic ras p21 (by similarity).
4602	
4603	
4604	
4605	catalyzes the synthesis of dihydrouridine, a modified base found in the d-loop of most trnas. modifies yeast pre- trna(phe) in vitro at u17.
4606	may be an organic anion pump relevant to cellular detoxification.
4607	involved in gpi-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of gpi (by similarity).
4608	
4609	receptor for the cytotoxic ligand tnfsf10/trail. the adapter molecule fadd recruits caspase-8 to the activated receptor. the resulting death-inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. promotes the activation of nf- kappa-b.
4610	orphan receptor. probable mediator of ebv effects on b lymphocytes or of normal lymphocyte functions.
4611	may act as scaffold protein.
4612	
4613	the elongation of primed dna templates by dna polymerase delta and epsilon requires the action of the accessory proteins pcna and activator 1. subunit 1 is essential for cell cycle progression. it may associate with components of the dna replication machinery and serve to enhance the efficiency of dna replication.
4614	adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates.
4615	may be involved in transcriptional regulation.
4616	
4617	
4618	
4619	bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (fgf) but inhibits the growth of cultured vascular endothelial cells. may contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development.
4620	calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). it can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.
4621	
4622	
4623	
4624	
4625	
4626	
4627	may be essential for the correct composition of cartilage and bone matrix during development. has no activity toward steroid sulfates.
4628	
4629	
4630	
4631	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
4632	may act as scaffold protein.
4633	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
4634	
4635	
4636	
4637	integrin alpha-1/beta-1 is a receptor for laminin and collagen. it recognizes the proline-hydroxylated sequence g-f-p-g- e-r in collagen.
4638	
4639	plasma membrane t-snare that mediates docking of transport vesicles. necessary for the translocation of slc2a4 from intracellular vesicles to the plasma membrane. may also play a role in docking of synaptic vesicles at presynaptic active zones.
4640	transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. involved in particular in lens epithelial cell gene regulation and stress responses. may play an important role in lens epithelial to fiber cell terminal differentiation. may play a protective role during stress-induced apoptosis. isoform 2 is a more general and stronger transcriptional coactivator. isoform 2 may also act as an adapter to coordinate pre-mrna splicing. cellular cofactor for lentiviral integration.
4641	necessary for efficient rna polymerase ii transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by s-ii allows the resumption of elongation from the new 3@#$%&terminus.
4642	may play a role in cell differentiation in the intestinal epithelium.
4643	may play an important role in the control of the immune response and during pregnancy (by similarity).
4644	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
4645	required for dna recombination, repair and replication. the activity of rp-a is mediated by single-stranded dna binding and protein interactions.
4646	npy is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
4647	may be involved in diverse cell survival mechanisms.
4648	
4649	inter-alpha-trypsin inhibitor, present in plasma and urine, inhibits trypsin, plasmin, and lysosomal granulocytic elastase.
4650	
4651	
4652	
4653	receptor for the hormone galanin.
4654	involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26s proteasome (by similarity).
4655	
4656	
4657	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
4658	v-snare that mediates vesicle transport pathways through interactions with t-snares on the target membrane. these interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.
4659	
4660	
4661	
4662	
4663	interacts with guanosine triphosphate (gtp)-bound forms of rab6a and rab6b. may act as a motor required for the retrograde rab6 regulated transport of golgi membranes and associated vesicles along microtubles. has a microtubule plus end-directed motility (by similarity).
4664	
4665	
4666	its physiological role is not yet clear.
4667	likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. capable of cleavage at the rx(k/r)r consensus motif.
4668	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to g-alpha subfamily 1 members, with the order g(i)a3 > g(i)a1 > g(o)a >> g(z)a/g(i)a2. activity on g(z)-alpha is inhibited by phosphorylation and palmitoylation of the g-protein.
4669	could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. has guanine nucleotide-binding activity but undetectable intrinsic gtpase activity.
4670	
4671	may serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
4672	involved in mediating u snrna export from the nucleus. binds to 5@#$%& capped mrna.
4673	
4674	
4675	component of the peroxisomal translocation machinery with pex14 and pex17. functions as a docking factor for the predominantly cytoplasmic pts1 receptor (pas10/pex5). involved in the import of pts1 and pts2 proteins.
4676	iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones t(3) and t(4).
4677	
4678	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
4679	inhibits human amidolytic and kininogenase activities of tissue kallikrein. inhibition is achieved by formation of an equimolar, heat- and sds-stable complex between the inhibitor and the enzyme, and generation of a small c-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.
4680	
4681	may have a role in promoting cell migration (motogen).
4682	
4683	
4684	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
4685	may be a transcription factor involved in regulating the expression of genes active in the s phase during cell cycle progression in t-cells. may be involved in tumor progression (by similarity). represses ela2 transcription.
4686	
4687	this enzyme is required for electron transfer from nadp to cytochrome p450 in microsomes. it can also provide electron transfer to heme oxygenase and cytochrome b5. may function to clear the olfactory organ (antennae) from accumulating chemicals.
4688	involved in protein n-glycosylation. essential for the second step of the dolichol-linked oligosaccharide pathway.
4689	bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. catalyzes the formation of 3- ketoacyl-coa intermediates from both straight-chain and 2-methyl- branched-chain fatty acids (by similarity).
4690	
4691	
4692	involved in the presentation of foreign antigens to the immune system.
4693	
4694	
4695	
4696	
4697	may convert the inactive conformation of integrin alpha- iib/beta3 to an active form through the binding to the integrin cytoplasmic domain.
4698	intracellular transport of retinol.
4699	
4700	
4701	
4702	catalyzes c14-demethylation of lanosterol; it transforms lanosterol into 4,4@#$%&-dimethyl cholesta-8,14,24-triene-3-beta-ol.
4703	
4704	
4705	
4706	
4707	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
4708	
4709	
4710	molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
4711	c9 is the final component of the complement system to be added in the assembly of the membrane attack complex. it is able to enter lipid bilayers, forming transmembrane channels.
4712	phosphorylates microtubule-associated protein 2 (map2). myelin basic protein (mbp), and elk-1; may promote entry in the cell cycle.
4713	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
4714	may deubiquitinate one or more critical proteins that are involved in the condensation of mitotic chromosomes, possibly acting selectively on histones h2a and h2b, the major ubiquitinated proteins of chromatin. it is able to deubiquitinate histone h2a in vitro, the phosphorylated form of the protein is also enzymatically active.
4715	
4716	links covalently the heme group to the apoprotein of cytochrome c (by similarity).
4717	
4718	works in concert with the 5alpha/5beta-steroid reductases to convert steroid hormones into the 3alpha/5alpha and 3alpha/5beta-tetrahydrosteroids. catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5alpha-dht) to 5-alpha-androstane-3alpha,17beta-diol (3-alpha-diol).
4719	protease that catalyzes two essential functions in the sumo pathway: processing of full-length smt3 to its mature form and deconjugation of smt3 from targeted proteins. has an essential role in the g2/m phase of the cell cycle.
4720	has dna hydrolytic activity. does not bind to actin. cleaves chromatin dna to nucleosomal units.
4721	histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a central role in histone code. preferentially demethylates mono- and dimethylated h3 lys-9 residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated h3 lys-9. demethylation of lys residue generates formaldehyde and succinate. involved in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes, resulting in h3 lys-9 demethylation and transcriptional activation.
4722	
4723	
4724	converts lysophosphatidic acid (lpa) into phosphatidic acid by incorporating acyl moiety at the 2 position.
4725	
4726	
4727	
4728	catalyzes the nadph-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
4729	
4730	acts as a multispecific organic anion pump which can transport nucleotide analogs.
4731	plays a role in dna repair by forming with ddb2 the uv- damaged dna-binding protein complex (uv-ddb). component of the rbx1-cul4-ddb2 ubiquitin ligase.
4732	may be involved in cell growth. probably acts as a terminal oxidase of plasma electron transport from cytosolic nad(p)h via hydroquinones to acceptors at the cell surface. hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. the activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
4733	
4734	
4735	
4736	iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones t(3) and t(4).
4737	collagen type iii occurs in most soft connective tissues along with type i collagen.
4738	
4739	
4740	catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the c-terminus of several proteins. the beta subunit is responsible for peptide-binding.
4741	
4742	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. signaling by wnt-7a allows sexually dimorphic development of the mullerian ducts (by similarity).
4743	
4744	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
4745	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules.
4746	receptor for msh (alpha, beta and gamma) and acth. this receptor is mediated by g proteins which activate adenylate cyclase.
4747	
4748	
4749	catalyzes the conversion of 3@#$%&-phosphate to a 2@#$%&,3@#$%&- cyclic phosphodiester at the end of rna. the mechanism of action of the enzyme occurs in 3 steps: (a) adenylation of the enzyme by atp; (b) the enzyme acts on rna-n3@#$%&p to produce rna-n3@#$%&pp5@#$%&a; (c) a non catalytic nucleophilic attack by the adjacent 2@#$%&hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. the biological role of this enzyme is unknown but it is likely to function in some aspects of cellular rna processing.
4750	protein phosphatase (pp1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. involved in regulation of ionic conductances and long-term synaptic plasticity.
4751	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
4752	
4753	binds dna with high affinity. may also be involved in protein-protein interactions (by similarity).
4754	
4755	
4756	may be involved in several stages of intracellular trafficking (by similarity).
4757	major component of the vertebrate myofibrillar m band. binds myosin, titin, and light meromyosin. this binding is dose dependent.
4758	acts as a co-chaperone with an hsp70 protein (by similarity).
4759	contributes to invasiveness in malignant prostate cancer.
4760	deubiquitinating enzyme which may be involved in brca1 signal transduction pathway.
4761	may be involved in several stages of intracellular trafficking (by similarity).
4762	bifunctional growth-modulating glycoprotein. inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells.
4763	may be involved in transcriptional regulation.
4764	
4765	
4766	nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. coactivates expression in an agonist- and af2-dependent manner. involved in the coactivation of different nuclear receptors, such as for steroids (gr and ers), retinoids (rars and rxrs), thyroid hormone (trs), vitamin d3 (vdr) and prostanoids (ppars). probably functions as a general coactivator, rather than just a nuclear receptor coactivator. may also be involved in the coactivation of the nf-kappa-b pathway. may coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
4767	may play a role in host defense against tumors and pathogens. binds z-dna (by similarity).
4768	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
4769	trap proteins are part of a complex whose function is to bind calcium to the er membrane and thereby regulate the retention of er resident proteins.
4770	chloride channel or a regulator or accessory subunit of other proteins that could provide the pore-froming function.
4771	
4772	
4773	
4774	important negative regulator in hematopoiesis and immune systems; may be involved in ending inflammatory responses through its inhibitory functions. inhibits endothelial nf-kappa-b signaling through a camp-dependent pathway. inhibits tnf-alpha- induced expression of endothelial adhesion molecules. involved in the control of fat metabolism and insulin sensitivity.
4775	
4776	involved in peroxisome biosynthesis and integrity. assembles membrane vesicles before the matrix proteins are translocated. as a docking factor for pex19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
4777	
4778	type i collagen is a member of group i collagen (fibrillar forming collagen).
4779	
4780	required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
4781	removes residual c-terminal arg or lys remaining after initial endoprotease cleavage during prohormone processing. processes proinsulin.
4782	
4783	transcriptional repressor. binds with max to form a sequence-specific dna-binding protein complex which recognizes the core sequence cac[ga]tg. antagonizes myc transcriptional activity by competing for max (by similarity).
4784	
4785	
4786	
4787	phosphorylates proteins on serine, threonine, and tyrosine. probably associated with cell proliferation.
4788	
4789	may be involved in the regulation of gene transcription and chromatin structure.
4790	may be involved in transcriptional regulation.
4791	
4792	
4793	binds to dna at special at-rich sequences at nuclear matrix- or scaffold-associated regions. thought to recognize the sugar-phosphate structure of double-stranded dna.
4794	
4795	
4796	seems to act exclusively upon threonine residues (by similarity).
4797	
4798	
4799	
4800	
4801	has a strict specificity for hydrolysis of asparaginyl bonds. can also cleave aspartyl bonds slowly, especially under acidic conditions. may be involved in the processing of proteins for mhc class ii antigen presentation in the lysosomal/endosomal system.
4802	molecular chaperone that functions in the processing and transport of secreted proteins (by similarity).
4803	essential component of the cop9 signalosome complex (csn), a complex involved in various cellular and developmental processes. the csn complex is an essential regulator of the ubiquitin (ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of scf-type e3 ligase complexes, leading to decrease the ubl ligase activity of scf-type complexes such as scf, csa or ddb2. the complex is also involved in phosphorylation of p53/tp53, c-jun/jun, ikappabalpha/nfkbia, itpk1 and irf8/icsbp, possibly via its association with ck2 and pkd kinases. csn- dependent phosphorylation of tp53 and jun promotes and protects degradation by the ubl system, respectively. involved in early stage of neuronal differentiation via its interaction with nif3l1.
4804	
4805	
4806	
4807	
4808	
4809	
4810	modulator of adipocyte lipid metabolism, it coats lipid storage droplets to protect them to be broken down by hormone- sensitive lipase (hsl). its absence may result in leanness.
4811	mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. the receptor recognizes terminal galactose and n-acetylgalactosamine units. after ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. the receptor then returns to the cell membrane surface.
4812	
4813	component of the e3 ubiquitin ligase dcx det1-cop1 complex, which is required for ubiquitination and subsequent degradation of target proteins. the complex is involved in jun ubiquitination and degradation.
4814	
4815	
4816	
4817	
4818	may be involved in transcriptional regulation.
4819	chemotactic factor for t-lymphocytes but not monocytes or granulocytes. may play a role in t-cell development in thymus and in trafficking and activation of mature t-cells. binds to ccr4.
4820	overproduction suppresses the slow growth phenotype of cpr7 mutant cells.
4821	
4822	
4823	
4824	
4825	
4826	may be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors (by similarity).
4827	
4828	type i collagen is a member of group i collagen (fibrillar forming collagen).
4829	
4830	
4831	promotes caspase-mediated apoptosis. this proapoptotic activity is mediated predominantly through the activation of caspase 9. may be a component of the inflammasome, a protein complex which also includes nalp2, card8 and casp1 and whose function would be the activation of proinflammatory caspases (by similarity).
4832	
4833	
4834	
4835	
4836	
4837	acts as a regulatory subunit of the 26 proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
4838	not known. may be involved in the synthesis of the sugar donor dol-p-man which is required in the synthesis of n-linked and o-linked oligosaccharides and for that of gpi anchors (by similarity).
4839	mediates the binding and degradation of acetylated low density lipoprotein (ac-ldl). mediates heterophilic interactions, suggesting a function as adhesion protein (by similarity).
4840	
4841	may play a role in mediating the heat shock response of some hsp70 genes. it is required for optimal growth of yeast cells at both low and high temperature.
4842	
4843	plays an important role in the normal skeletal development. may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
4844	
4845	muscle contraction.
4846	
4847	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation by repressing transcription of myocyte enhancer mef2c. during muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.
4848	favors the reduction of estrogens and androgens. also has 20-alpha-hsd activity. uses preferentially nadh.
4849	
4850	chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. signals through ccr2b and ccr3 receptors. plays a role in the accumulation of leukocytes at both sides of allergic and nonallergic inflammation. may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. may play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
4851	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
4852	
4853	
4854	
4855	
4856	
4857	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
4858	
4859	endonuclease that specifically degrades the rna of rna- dna hybrids.
4860	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
4861	
4862	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
4863	
4864	collagen type iv is specific for basement membranes. vital for embryonic development.
4865	
4866	transcription factor that binds to the immunoglobulin enchancer mu-e5/ke5-motif. binds to the e-box present in the somatostatin receptor 2 initiator element (sstr2-inr) to activate transcription (by similarity). preferentially binds to either 5@#$%&- acanntgt-3@#$%& or 5@#$%&-ccanntgg-3@#$%&.
4867	catalyzes the reduction of 3-ketodihydrosphingosine (kds) to dihydrosphingosine (dhs).
4868	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
4869	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
4870	this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of sodium and potassium ions across the plasma membrane. this action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
4871	
4872	receptor for extracellular adenine nucleotides such as atp and adp. in platelets binding to adp leads to mobilization of intracellular calcium ions via activation of phospholipase c, a change in platelet shape, and probably to platelet aggregation.
4873	
4874	
4875	
4876	necessary for the catabolism of n-linked carbohydrates released during glycoprotein turnover. cleaves all known types of alpha-mannosidic linkages.
4877	
4878	inhibits nf-kappa-b activation. may participate in a regulatory mechanism that coordinates cellular responses controlled by nf-kappa-b transcription factor. may be a component of the inflammasome, a protein complex which also includes pycard, nalp2 and casp1 and whose function would be the activation of proinflammatory caspases.
4879	
4880	
4881	
4882	inhibitor of hgf activator. also inhibits plasmin, plasma and tissue kallikrein, and factor xia.
4883	may be involved in transcriptional regulation.
4884	
4885	may be involved in transcriptional regulation.
4886	component of the drb sensitivity-inducing factor complex (dsif complex), which regulates mrna processing and transcription elongation by rna polymerase ii. dsif positively regulates mrna capping by stimulating the mrna guanylyltransferase activity of rngtt/cap1a. dsif also acts cooperatively with the negative elongation factor complex (nelf complex) to enhance transcriptional pausing at sites proximal to the promoter. transcriptional pausing may facilitate the assembly of an elongation competent rna polymerase ii complex. dsif and nelf promote pausing by inhibition of the transcription elongation factor tfiis/s-ii. tfiis/s-ii binds to rna polymerase ii at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. cleavage of blocked transcripts by rna polymerase ii promotes the resumption of transcription from the new 3@#$%& terminus and may allow repeated attempts at transcription through natural pause sites. dsif can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the hiv- 1 nuclear transcriptional activator, tat. dsif acts to suppress transcriptional pausing in transcripts derived from the hiv-1 ltr and blocks premature release of hiv-1 transcripts at terminator sequences.
4887	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
4888	subunit of the splicing factor sf3a required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex.
4889	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
4890	associated with snrnp u1, u2, u4/u6 and u5.
4891	seems to be required for the activation of 5-lo (5- lipoxygenase). flap could play an essential role in the transfer of arachidonic acid to 5-lo. flap binds to mk-886, a compound that blocks the biosynthesis of leukotrienes.
4892	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
4893	may be a dna-binding protein with a regulatory function. may play an important role in cell death and/or in regulation of cell proliferation.
4894	non-covalently associates with membrane glycoproteins of the killer-cell inhibitory receptor (kir) family without an itim in their cytoplasmic domain. crosslinking of kir-tyrobp complexes results in cellular activation.
4895	transcription factor that appears to be required for the t-cell-receptor-mediated trans activation of hiv-2 gene expression. binds specifically to two purine-rich motifs in the hiv-2 enhancer. transcriptionally activates the lyn and mouse blk promoters.
4896	
4897	
4898	involved in the metabolism of neuropeptides under 20 amino acid residues long. involved in cytoplasmic peptide degradation. able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.
4899	
4900	could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. essential for embryonic development. protects from radiation and oxidative damage (by similarity).
4901	snare that may function to receive vesicles either from the golgi stack or from the endosome.
4902	dna-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (ig)/t-cell receptor gene segments. seems to recognize single-stranded dna ends generated by staggered breaks occuring at recombination hot spots.
4903	this is a receptor for secretin. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
4904	involved in the presentation of foreign antigens to the immune system.
4905	mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient.
4906	
4907	
4908	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
4909	non-specific receptor for endothelin 1, 2, and 3. mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system.
4910	required for the high affinity binding of interleukin 18 (il-18) to its receptor complex (by similarity). together with il18r1 mediates il-18-dependent activation of nf-kappa-b and jnk.
4911	
4912	
4913	
4914	
4915	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. rna polymerase i is essentially used to transcribe ribosomal dna units.
4916	may play a role in granule-membrane fusion and degranulation.
4917	
4918	
4919	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
4920	
4921	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
4922	component of the cleavage and polyadenylation specificity factor (cpsf) complex that play a key role in pre-mrna 3@#$%&-end formation, recognizing the aauaaa signal sequence and interacting with poly(a) polymerase and other factors to bring about cleavage and poly(a) addition.
4923	catalyzes the synthesis of the excitotoxin quinolinic acid (quin) from 3-hydroxyanthranilic acid. the direct product of the reaction spontaneously rearrange to quin.
4924	
4925	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
4926	
4927	
4928	part of the complex catalyzing the transfer of n- acetylglucosamine from udp-n-acetylglucosamine to phosphatidylinositol, the first step of gpi biosynthesis.
4929	probable immunoglobulin-like cell surface receptor.
4930	
4931	
4932	this protein is an auxiliary protein of dna polymerase delta and is involved in the control of eukaryotic dna replication by increasing the polymerase@#$%&s processibility during elongation of the leading strand.
4933	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this form has a role in retina signal transduction.
4934	motor for anterograde axonal transport of synaptic vesicle precursors (by similarity).
4935	
4936	component of the escrt-iii complex, which is required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs. the mvb pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. the escrt-iii complex is probably involved in the concentration of mvb cargo. in the escrt-iii complex, it probably serves as an acceptor for escrt-i complex on endosomal membranes. in case of infection, the hiv-1 virus takes advantage of the escrt-iii complex for budding and exocytic cargos of viral proteins, via the association of chmp4 proteins with pdcd6ip/aip1, a protein directly recruited by hiv-1 p6 protein that functions at sites of viral gag assembly and budding.
4937	
4938	
4939	
4940	part of the receptor for interferon gamma. required for signal transduction. this accessory factor is an integral part of the ifn-gamma signal transduction pathway and is likely to interact with gaf, jak1, and/or jak2.
4941	catalyzes the reduction of a wide variety of carbonyl compounds including the antitumor anthracycline antibiotics. can convert prostaglandin e2 to prostaglandin f2-alpha.
4942	
4943	transporter for the intake of folate. uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a v-type h(+)-pump.
4944	
4945	involved in multiple membrane trafficking steps.
4946	
4947	
4948	although its physiological function is unclear, it can inhibit neutrophil cathepsin g and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
4949	carrier protein. binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. binds with high affinity to alpha-tocopherol. also binds with a weaker affinity to other tocopherols and to tocotrienols. may have a transcriptional activatory activity via its association with alpha-tocopherol. probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
4950	
4951	
4952	probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
4953	
4954	formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. other thiol compounds, besides cyanide, can act as sulfur ion acceptors. also has weak mercaptopyruvate sulfurtransferase (mst) activity (by similarity).
4955	the h1@#$%&/h1.0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division. structurally and functionally the h1@#$%& family appears intermediate with respect to the h1 and h5 families.
4956	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling. phosphorylates dvl1.
4957	
4958	may be required for the assembly pathway of mitochondrial outer membrane proteins (by similarity).
4959	
4960	may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of e4tf1. in tumor cell lines, may induce apoptosis.
4961	
4962	may be involved in transcriptional regulation.
4963	involved in the regulation of cell adhesion and in signal transduction through the wnt pathway.
4964	involved in the regulation of cell adhesion and in signal transduction through the wnt pathway.
4965	
4966	may be involved in protein transport (by similarity).
4967	
4968	
4969	
4970	general protein kinase capable of phosphorylating several known proteins. phosphorylates tbc1d4. signals downstream of phosphatidylinositol 3-kinase (pi(3)k) to mediate the effects of various growth factors such as platelet-derived growth factor (pdgf), epidermal growth factor (egf), insulin and insulin-like growth factor i (igf-i). plays a role in glucose transport by mediating insulin-induced translocation of the glut4 glucose transporter to the cell surface. mediates the antiapoptotic effects of igf-i. mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4e-bp1 and in insulin-induced activation of p70 s6 kinase. promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.
4971	microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
4972	
4973	possible tumor suppressor.
4974	
4975	
4976	
4977	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
4978	plays an important role in fat metabolism. it preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
4979	required for assembly of the mitotic spindle. interact with spindle microtubules to produce an outwardly directed force acting upon the poles. following spindle assembly, cin8 and kip1 apparently act to oppose a force that draws separated poles back together. this force seems to be mediate by kar3.
4980	interacts with lrp1/alpha-2-macroglobulin receptor and glycoprotein 330.
4981	general vesicular transport factor required for intercisternal transport in the golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. may well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (by similarity).
4982	
4983	
4984	c/ebp are dna-binding proteins that recognize two different motifs: the ccaat homology common to many promoters and the enhanced core homology common to many enhancers.
4985	participates in the innate immune response to microbial agents. may be involved in the recognition of ds-rna. acts via myd88 and traf6, leading to nf-kappa-b activation, cytokine secretion and the inflammatory response (by similarity).
4986	
4987	may be involved in the regulation of dopamine release and transport. soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). induces fibrillization of microtubule- associated protein tau. reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation.
4988	cytokine that stimulates the proliferation of t- lymphocytes. stimulation by il-15 requires interaction of il-15 with components of il-2r, including il-2r beta and probably il-2r gamma but not il-2r alpha.
4989	
4990	required for the insertion of integral membrane proteins into the mitochondrial inner membrane. essential for the activity and assembly of cytochrome oxidase.
4991	
4992	receptor that binds both pdgfa and pdgfb and has a tyrosine-protein kinase activity.
4993	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
4994	involved in the presentation of foreign antigens to the immune system.
4995	
4996	
4997	involved in the activation cascade of caspases responsible for apoptosis execution. cleaves poly(adp-ribose) polymerase in vitro, as well as lamins. overexpression promotes programmed cell death (by similarity).
4998	
4999	probable histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a central role in histone code. demethylation of lys residue generates formaldehyde and succinate. may be involved in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes (by similarity).
5000	
5001	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
5002	vinexin alpha isoform promotes up-regulation of actin stress fiber formation. vinexin beta isoform plays a role in cell spreading and enhances the activation of jnk/sapk in response to egf stimulation by using its third sh3 domain.
5003	
5004	ubiquitin ligase protein which is a component of the n- end rule pathway. recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the n-end rule, leading to their ubiquitination and subsequent degradation.
5005	has e3 ubiquitin ligase activity. the ccr4-not complex functions as general transcription regulation complex.
5006	
5007	
5008	
5009	
5010	
5011	
5012	
5013	may have a role in host defense.
5014	
5015	membrane-cytoskeleton linker. the neural-specific isoforms may participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of ranvier and axonal initial segments.
5016	component of the escrt-iii complex, which is required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs. the mvb pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. the escrt-iii complex is probably involved in the concentration of mvb cargo. in the escrt-iii complex, it probably serves as an acceptor for escrt-i complex on endosomal membranes. in case of infection, the hiv-1 virus takes advantage of the escrt-iii complex for budding and exocytic cargos of viral proteins, via the association of chmp4 proteins with pdcd6ip/aip1, a protein directly recruited by hiv-1 p6 protein that functions at sites of viral gag assembly and budding.
5017	mediates selective neuronal growth and axon targeting. contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. essential for normal growth of the hyppocampal mossy fiber projection (by similarity).
5018	may function as a dna-binding transcription factor. binds to the macrophage-specific tpa-responsive element (mte) of the hmox1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
5019	
5020	vasorelaxant activity. has a cgmp-stimulating activity.
5021	serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. after activation by auto-catalytic cleavage it cleaves c2 and c4, leading to their activation and to the formation of c3 convertase.
5022	
5023	may function as a testis specific transcription factor. binds dna in conjunction with gtf2a2 and tbp (the tata-binding protein) and together with gtf2a2, allows mrna transcription.
5024	
5025	
5026	may regulate the disassembly of focal adhesions. may localize receptor-like tyrosine phosphatases type 2a at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
5027	
5028	
5029	may play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia (by similarity).
5030	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to g(i)-alpha and g(q)-alpha (by similarity).
5031	
5032	
5033	
5034	
5035	binds to the sequences 5@#$%&-aatgtaggtca-3@#$%& and 5@#$%&- ataactaggtca-3@#$%&. acts as a potent competitive repressor of ror alpha function (by similarity).
5036	
5037	
5038	required for membrane traffic to the vacuole.
5039	
5040	heparin binding mitogenic protein. has neurite extension activity.
5041	receptor for acidic and basic fibroblast growth factors.
5042	has a transcriptional repressor activity by cooperating with epc1. induces apoptosis by activating jun n-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. may function in male germ cell development. has dna-binding activity and preferentially bound to double-stranded dna (by similarity).
5043	catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (spp), a lipid mediator with both intra- and extracellular functions. also acts on d-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as d,l-threo-dihydrosphingosine, n,n-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
5044	
5045	
5046	may be involved in protein trafficking from the plasma membrane to the early endosome (ee) as well as in homotypic fusion of endocytic organelles. mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.
5047	involved in the cornified cell envelope formation. multifunctional epidermal matrix protein.
5048	
5049	regulates cdk7, the catalytic subunit of the cdk- activating kinase (cak) enzymatic complex. cak activates the cyclin-associated kinases cdc2/cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation. cak complexed to the core-tfiih basal transcription factor activates rna polymerase ii by serine phosphorylation of the repetitive c-terminus domain (ctd) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts. involved in cell cycle control and in rna transcription by rna polymerase ii. its expression and activity are constant throughout the cell cycle.
5050	may function as a transcription factor.
5051	orphan receptor.
5052	catalyzes the posttranslational formation of 4- hydroxyproline in -xaa-pro-gly- sequences in collagens and other proteins.
5053	
5054	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules (by similarity).
5055	
5056	may function as suppressor of malignant melanoma. it may exert its effects through interactions with the cytoskeleton.
5057	may function as suppressor of malignant melanoma. it may exert its effects through interactions with the cytoskeleton.
5058	crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. the beta-2 subunit causes an increase in the plasma membrane surface area and in its folding into microvilli. interacts with tnr may play a crucial role in clustering and regulation of activity of sodium channels at nodes of ranvier.
5059	
5060	promotes guanine-nucleotide exchange on arf1 and arf3. promotes the activation of arf1/arf3 through replacement of gdp with gtp.
5061	
5062	
5063	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
5064	the 26s protease is involved in the atp-dependent degradation of ubiquitinated proteins. the regulatory (or atpase) complex confers atp dependency and substrate specificity to the 26s complex. positive modulator of tat-mediated transactivation.
5065	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
5066	interacts with zinc finger protein a20/tnfaip3 and inhibits tnf-induced nf-kappa-b-dependent gene expression by interfering with an rip- or traf2-mediated transactivation signal (by similarity). increases cell surface cd4(t4) antigen expression. interacts with hiv-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. may regulate matrix nuclear localization, both nuclear import of pic (preintegration complex) and export of gag polyprotein and viral genomic rna during virion production.
5067	
5068	
5069	
5070	thought to be important for regulating terminal differentiation and/or proliferation.
5071	
5072	
5073	type i collagen is a member of group i collagen (fibrillar forming collagen).
5074	
5075	transcriptional repressor of genes that require a bhlh protein for their transcription (by similarity).
5076	involved in rna splicing. is required for the association of u4/u6 snrnp with u5 snrnp in an early step of spliceosome assembly.
5077	receptor for bradykinin. it is associated with g proteins that activate a phosphatidylinositol-calcium second messenger system.
5078	posttranslational modification of specific protein by attachment of biotin. acts on various carboxylases such as acetyl- coa-carboxylase, pyruvate carboxylase, propionyl coa carboxylase, and 3-methylcrotonyl coa carboxylase.
5079	catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of nad. it is the rate limiting component in the mammalian nad biosynthesis pathway (by similarity).
5080	mediates selective neuronal growth and axon targeting. contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. essential for normal growth of the hyppocampal mossy fiber projection.
5081	
5082	
5083	
5084	involved in t-cell antigen receptor mediated signaling.
5085	
5086	
5087	the reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of dna to another.
5088	binds crf and inactivates it. may prevent inappropriate pituitary-adrenal stimulation in pregnancy.
5089	
5090	may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of e4tf1. in tumor cell lines, may induce apoptosis.
5091	transcriptional repressor of a number of genes including sp1 target genes.
5092	
5093	
5094	
5095	
5096	phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
5097	probable transcription factor. may play an important role in recruitment of elf4 into pml nuclear bodies.
5098	major acute phase reactant. apolipoprotein of the hdl complex.
5099	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
5100	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
5101	
5102	
5103	
5104	may activate nf-kappa-b and jnk and promote apoptosis.
5105	may contribute to the transparency and refractive index of the lens.
5106	
5107	
5108	
5109	stimulates the dissociation of gdp from the ras-related rala and ralb gtpases which allows gtp binding and activation of the gtpases. interacts and acts as an effector molecule for r-ras, h-ras, k-ras, and rap.
5110	may be involved in transcriptional regulation.
5111	involved in cytokinesis (potential).
5112	
5113	
5114	
5115	this proteoglycan is a major component of extracellular matrix of cartilagenous tissues. a major function of this protein is to resist compression in cartilage. it binds avidly to hyaluronic acid via an n-terminal globular region.
5116	
5117	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
5118	may play an important role in spermatogenesis and/or testis development.
5119	
5120	type i collagen is a member of group i collagen (fibrillar forming collagen).
5121	
5122	
5123	f-actin capping proteins bind in a ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
5124	histone h3, along with histone h4, plays a central role in nucleosome formation.
5125	nup98 and nup96 play a role in the bidirectional transport across the nucleoporin complex (npc). the repeat domain in nup98 has a direct role in the transport.
5126	histone h4, along with histone h3, plays a central role in nucleosome formation.
5127	may function in chaperone-mediated protein folding.
5128	
5129	
5130	
5131	
5132	
5133	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
5134	scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. necessary for recycling of internalized adrb2. was first known to play a role in the regulation of the activity and subcellular location of slc9a3. necessary for camp-mediated phosphorylation and inhibition of slc9a3. may enhance wnt signaling.
5135	likely to play a regulatory role in the development of the ventral forebrain. may play a role in craniofacial patterning and morphogenesis.
5136	
5137	catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine.
5138	seems to act as a chloride ion channel.
5139	
5140	
5141	
5142	
5143	
5144	
5145	
5146	binds to type ii regulatory subunits of protein kinase a. scaffolding protein that assembles several protein kinases and phosphatases on centrosome and golgi apparatus where physiological events can be regulated by phosphorylation state of protein substrates. isoform 4/yotiao is associated with the n-methyl-d- aspartate receptor and is specifically found in the neuromuscular junction (nmj) as well as in neuronal synapses explaining that its role may be to organize postsynaptic specializations.
5147	seems to play a role in testicular function. may be a trophic hormone with a role in testicular descent in fetal life. is a ligand for lgr8 receptor.
5148	
5149	
5150	
5151	
5152	plays a role in the import of cytosolically synthesized preproteins into mitochondria. binds the mature portion of precursor proteins. interacts with cellular components, and possesses weak atpase activity. may be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.
5153	
5154	
5155	nuclear hormone receptor. the steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
5156	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
5157	may be involved in transcriptional regulation.
5158	
5159	
5160	
5161	
5162	
5163	
5164	
5165	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
5166	
5167	may be involved in nucleolar-cytoplasmic transport. may play a fundamental role in early embryonic development, particularly in development of the craniofacial complex (by similarity).
5168	acts as a cofactor for xpo1/crm1-mediated nuclear export, perhaps as export complex scaffolding protein. bound to xpo1/crm1, stabilizes the xpo1/crm1-cargo interaction. in the absence of ran-bound gtp prevents binding of xpo1/crm1 to the nuclear pore complex. binds to chc1/rcc1 and increases the guanine nucleotide exchange activity of chc1/rcc1. recruits xpo1/crm1 to chc1/rcc1 in a ran-dependent manner.
5169	
5170	
5171	
5172	
5173	
5174	
5175	conversion of dopamine to noradrenaline.
5176	
5177	transcriptional activator; dna-binding protein that specifically recognize the sequence 5@#$%&-yaac[gt]g-3@#$%&. plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
5178	
5179	the normal physiological role of blm hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug blm (a glycopeptide) by hydrolyzing the carboxamide bond of its b- aminoalaninamide moiety thus protecting normal and malignant cells from blm toxicity (by similarity).
5180	
5181	collagen vi acts as a cell-binding protein.
5182	
5183	involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole.
5184	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
5185	involved in transcriptional regulation. represses the transcription of a number of genes including gastrin and ornithine decarboxylase. binds to the g-rich box in the enhancer region of these genes.
5186	
5187	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. displays high levels of activity on medium- and long chain acyl coas.
5188	
5189	
5190	
5191	plays a major role in ketone body metabolism.
5192	
5193	
5194	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes, such as ube2l3/ubcm4, and then transfers it to substrates.
5195	
5196	
5197	
5198	catalyzes the formation of the neuac-alpha-2,3-gal-beta- 1,4-glcnac-, neuac-alpha-2,3-gal-beta-1,3-glcnac- or neuac-alpha- 2,3-gal-beta-1,3-galnac- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. the highest activity is toward gal-beta-1,3-glcnac and the lowest toward gal-beta-1,3- galnac (by similarity).
5199	involved in cell adhesion. binds to cd166.
5200	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
5201	
5202	
5203	
5204	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
5205	integrin alpha-x/beta-2 is a receptor for fibrinogen. it recognizes the sequence g-p-r in fibrinogen. it mediates cell-cell interaction during inflammatory responses. it is especially important in monocyte adhesion and chemotaxis.
5206	
5207	the elongin bc complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different e3 ubiquitin ligase complexes, including the von hippel-lindau ubiquitination complex cbc(vhl). by binding to bc- box motifs it seems to link target recruitment subunits, like vhl and members of the socs box family, to cullin/rbx1 modules that activate e2 ubiquitination enzymes.
5208	
5209	interacts with the viral protein-binding domain of the retinoblastoma protein.
5210	may bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. may be under transcriptional regulation of steroid hormones.
5211	
5212	this is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. catalyzes the rate-limiting conversions of tyrosine to dopa, dopa to dopa-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
5213	seems to play an essential role in cold-induced suppression of cell proliferation.
5214	
5215	inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. kcnj13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.
5216	
5217	could be a melanogenic enzyme. could represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. release of the soluble form, me20-s, could protect tumor cells from antibody mediated immunity.
5218	
5219	
5220	transcriptional coactivator that specifically associates with either oct1 or oct2. it boosts the oct-1 mediated promoter activity and to a lesser extent, that of oct-2. it has no intrinsic dna-binding activity. it recognizes the pou domains of oct1 and oct2. it is essential for the response of b-cells to antigens and required for the formation of germinal centers.
5221	
5222	seems to be involved in transcriptional silencing in heterochromatin-like complexes. recognizes and binds histone h3 tails methylated at lys-9, leading to epigenetic repression. may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin b receptor (lbr). involved in the formation of functional kinetochore through interaction with mis12 complex proteins.
5223	
5224	may be involved in transcriptional regulation.
5225	may serve as a @#$%!flippase@#$%! as well as a glucosyltransferase that transfers glucose to ceramide.
5226	
5227	
5228	nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. involved in the coactivation of different nuclear receptors, such as for steroids (gr and er), retinoids (rars and rxrs), thyroid hormone (trs), vitamin d3 (vdr) and prostanoids (ppars). displays histone acetyltransferase activity. also involved in the coactivation of the nf-kappa-b pathway via its interaction with the nfkb1 subunit.
5229	nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. involved in the coactivation of different nuclear receptors, such as for steroids (gr and er), retinoids (rars and rxrs), thyroid hormone (trs), vitamin d3 (vdr) and prostanoids (ppars). displays histone acetyltransferase activity. also involved in the coactivation of the nf-kappa-b pathway via its interaction with the nfkb1 subunit.
5230	
5231	
5232	component of a protein kinase signal transduction cascade. regulates the jnk and erk5 pathways by phosphorylating and activating map2k5 and map2k7 (by similarity). plays a role in caveolae kiss-and-run dynamics.
5233	component of a protein kinase signal transduction cascade. regulates the jnk and erk5 pathways by phosphorylating and activating map2k5 and map2k7 (by similarity). plays a role in caveolae kiss-and-run dynamics.
5234	
5235	probable atp-binding rna helicase.
5236	required for protein transport from the er to the golgi complex.
5237	
5238	hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters (by similarity). has antioxidant activity. is not associated with high density lipoprotein. prevents ldl lipid peroxidation, reverses the oxidation of mildly oxidized ldl, and inhibits the ability of mm-ldl to induce monocyte chemotaxis.
5239	
5240	
5241	
5242	gtpase activator for the rho, rac and cdc42 proteins, converting them to the putatively inactive gdp-bound state. cdc42 seems to be the preferred substrate.
5243	
5244	
5245	
5246	sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. has no activity toward desulfated n-resulfated heparin.
5247	interacts with the cytoplasmic tail of nmda receptor subunits and shaker-type potassium channels. required for synaptic plasticity associated with nmda receptor signaling. overexpression or depletion of dlg4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. may reduce the amplitude of accn3 acid-evoked currents by retaining the channel intracellularly. may regulate the intracellular trafficking of adr1b.
5248	required for protein transport from the er to the golgi complex.
5249	dsp may be an important factor in dentinogenesis. dpp may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.
5250	
5251	metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (eet).
5252	may act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
5253	
5254	stimulates the transcription of various genes by recognizing and binding to a ccaat motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
5255	
5256	
5257	
5258	3-phosphorylates the cellular phosphoinositide ptdins- 4,5-biphosphate (ptdins(4,5)p2) to produce ptdins-3, 4,5- triiphosphate (ptdins(3,4,5)p3). links g-protein coupled receptor activation to the secondary messenger ptdins(3,4,5)p3 production.
5259	stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
5260	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
5261	
5262	
5263	receptor for the tridecapeptide neurotensin. it is associated with g proteins that activate a phosphatidylinositol- calcium second messenger system.
5264	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein.
5265	
5266	binds heavy metals. contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. inhibits survival and neurite formation of cortical neurons in vitro.
5267	
5268	
5269	this protein binds preferentially and cooperatively to ss-dna. probably involved in mitochondrial dna replication.
5270	produced by activated monocytes and neutrophils and expressed at sites of inflammation. hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. gro-beta(5-73) shows a highly enhanced hematopoietic activity.
5271	
5272	
5273	part of the rfx complex that binds to the x-box of mhc ii promoters.
5274	
5275	rab4/rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. required for endosome fusion either homotypically or with clathrin coated vesicles. plays a role in the lysosomal trafficking of cathepsin d from the golgi to lysosomes. also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (ptdinsp3).
5276	
5277	type i collagen is a member of group i collagen (fibrillar forming collagen).
5278	
5279	gtp-binding protein with gtpase activity. elicits the formation of f-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (by similarity).
5280	important for bud site selection.
5281	this protein may be a lipid transport protein in schwann cells.
5282	
5283	
5284	oxidizes the coa-esters of 2-methyl-branched fatty acids (by similarity).
5285	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
5286	replaces conventional h2a in a subset of nucleosomes. acts as a polycomb group (pcg) protein required to maintain the transcriptionally repressive state of homeotic genes of the animal throughout development. required for histone h3 lys-9 methylation and histone h4 lys-12 acetylation, two modifications that are essential for heterochromatin formation. also involved in dna double strand break (dsb) repair. essential for early development.
5287	
5288	
5289	
5290	plays a crucial role in coupling ngf stimulation to the activation of both ephb2 and mapk14 signaling pathways and in ngf- dependent neuronal differentiation.
5291	may play a role during embryogenesis. binds to the dna sequence 5@#$%&-gaaccaccca-3@#$%& which is part of the tre-2s regulatory element that augments the tax-dependent enhancer of human t-cell leukemia virus type 1. implicated in the transduction of shh signal.
5292	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. this component is involved in redox-linked proton pumping.
5293	
5294	
5295	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
5296	
5297	
5298	inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. may mediate the inhibitory effect of rac1 on endocytosis.
5299	implicated in the suppression of cell death. interacts with the bcl-2 and adenovirus e1b 19 kda proteins.
5300	
5301	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
5302	
5303	may function in a signal transduction pathway that is restricted to b-lymphoid cells.
5304	
5305	may be involved in vesicular trafficking and neurotransmitter release (by similarity).
5306	calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction.
5307	induces the collapse and paralysis of neuronal growth cones. could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. binds to the complex neuropilin-1/plexin-1 (by similarity).
5308	binds and exchanges gtp and gdp.
5309	
5310	may play a role in vesicular transport from endoplasmic reticulum to golgi.
5311	
5312	
5313	transcriptional repressor.
5314	
5315	
5316	defensins 1/2 have antibiotic, fungicide and antiviral activities.
5317	
5318	may be an activator of the jnk/sapk pathway. phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
5319	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
5320	
5321	transcription factor required for gene expression specific to photoreceptor cells.
5322	regulates splicing and translation of various rnas. binds to (cug)n triplet repeats and to bruno response elements.
5323	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
5324	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
5325	
5326	
5327	
5328	may play a role in transcriptional regulation. in vitro, is associated with a kinase activity toward both rna polymerase ii c-terminal domain and cdk2 (cak).
5329	
5330	
5331	
5332	
5333	
5334	
5335	it may be responsible for the synthesis of the sequence neuac-alpha-2,3-gal-beta-1,3-galnac- found on sugar chains o- linked to thr or ser and also as a terminal sequence on certain gangliosides. siat4a and siat4b sialylate the same acceptor substrates but exhibit different km values.
5336	it may be responsible for the synthesis of the sequence neuac-alpha-2,3-gal-beta-1,3-galnac- found on sugar chains o- linked to thr or ser and also as a terminal sequence on certain gangliosides. siat4a and siat4b sialylate the same acceptor substrates but exhibit different km values.
5337	
5338	
5339	
5340	
5341	ph-dependent, voltage insensitive, outwardly rectifying potassium channel. outward rectification is lost at high external k(+) concentrations.
5342	may by one of the key factors that controls the specialized post-capillary high endothelial venules (hev) phenotype found in organized secondary lymphoid tissue.
5343	may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (by similarity).
5344	sequence-selective dna-binding protein. could play an important role in gene regulation.
5345	
5346	
5347	may be involved in neuronal differentiation and maintenance.
5348	
5349	acts as a microtubule-associated protein which interacts with cytoplasmic microtubules through beta-tubulin.
5350	
5351	
5352	functions in segment determination through interaction with genes of bithorax (bx-c) and antennapedia (ant-c) complexes. it can behave as an activator of bx-c. involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. shown to bind zinc (in vitro).
5353	dna repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. may be implicated in interstrand dna cross-link repair and in the maintenance of normal chromosome stability.
5354	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity).
5355	collagen type iv is specific for basement membranes. vital for embryonic development.
5356	
5357	defensins 1/2 have antibiotic, fungicide and antiviral activities.
5358	
5359	
5360	
5361	major keratinocyte cell envelope protein.
5362	
5363	phosphorylates microtubule-associated protein 2 (map2). may promote entry in the cell cycle (by similarity).
5364	
5365	
5366	
5367	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to g(i)-alpha and g(o)-alpha, but not to g(s)-alpha. may play a role in regulating the kinetics of signaling in the phototransduction cascade.
5368	required for kinetochore localization of bub1.
5369	required for normal golgi function (by similarity).
5370	
5371	transcription activator which binds specifically to the mef2 element present in the regulatory regions of many muscle- specific genes. controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. may also be involved in neurogenesis and in the development of cortical architecture (by similarity). isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
5372	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
5373	
5374	
5375	
5376	
5377	
5378	
5379	
5380	cleaves presequences (transit peptides) from mitochondrial protein precursors (by similarity).
5381	
5382	
5383	
5384	
5385	receptor for prostaglandin e2 (pge2); the ep3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. the activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by g(i) proteins, and to an elevation of intracellular calcium. the various forms can interact with different second messenger systems.
5386	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
5387	
5388	
5389	
5390	
5391	
5392	may inhibit cell replication either by catalyzing the oxidation of estrogen and androgen or by converting cortisone in cortisol.
5393	
5394	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
5395	
5396	
5397	
5398	
5399	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
5400	
5401	monokine with inflammatory and chemokinetic properties. binds to ccr1, ccr4 and ccr5. one of the major hiv-suppressive factors produced by cd8+ t-cells. recombinant mip-1-alpha induces a dose-dependent inhibition of different strains of hiv-1, hiv-2, and simian immunodeficiency virus (siv).
5402	thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
5403	
5404	pyruvate carboxylase catalyzes a 2-step reaction, involving the atp-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
5405	may play a role in the interaction between activated b lymphocytes and dendritic cells in tonsils.
5406	receptor for thyrotropin-releasing hormone. this receptor is mediated by g proteins which activate a phosphatidylinositol-calcium second messenger system.
5407	
5408	catalyzes the reduction, with the use of nadp, of hydrogen sulfide into sulfite and water (by similarity).
5409	
5410	may act as a transcriptional activator. binds the caccc core sequence. may be involved in the differentiation of epithelial cells and may also function in the development of the skeleton and kidney.
5411	
5412	
5413	
5414	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
5415	
5416	
5417	
5418	may regulate vesicle trafficking and modulate the subcellular distribution of slc2a4/glut4-vesicles. has parp activity and can modify terf1, and thereby contribute to the regulation of telomere length.
5419	
5420	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
5421	
5422	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
5423	
5424	
5425	may function as an adapter molecule that regulates traf3-mediated jnk activation (by similarity).
5426	
5427	
5428	
5429	
5430	
5431	potential mediator of cell growth. pro-apoptotic.
5432	implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2a, regulation of mrna trafficking and stability in association with elavl1, and inhibition of acetyltransferases as part of the inhat (inhibitor of histone acetyltransferases) complex.
5433	receptor for glutamate. the activity of this receptor is mediated by a g-protein that inhibits adenylate cyclase activity.
5434	type i collagen is a member of group i collagen (fibrillar forming collagen).
5435	
5436	
5437	
5438	
5439	
5440	component of the exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity.
5441	non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via g-protein coupled receptor (gpcr) occupancy by ligands such as bombesin or lysophosphatidic acid, or via ldl receptor occupancy. plays a potential role in oncogenic transformations resulting in increased kinase activity.
5442	
5443	
5444	acts as a sequence-specific transcriptional repressor in association with bcl6. may function in a narrow stage or be related to some events in the early b-cell development.
5445	
5446	
5447	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
5448	tp and tp5 may play a role in t-cell development and function. tp5 is an immunomodulating pentapeptide.
5449	
5450	may be required for testis development.
5451	major high molecular weight protein of desmosomes. involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
5452	
5453	
5454	inhibits gdp/gtp exchange reaction of rhob. interacts specifically with the gdp- and gtp-bound forms of post- translationally processed rhob and rhog proteins, both of which show a growth-regulated expression in mammalian cells. stimulates the release of the gdp-bound but not the gtp-bound rhob protein. also inhibits the gdp/gtp exchange of rhob but shows less ability to inhibit the dissociation of prebound gtp.
5455	required for protein transport from the er to the golgi complex.
5456	processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. involved in melanosome transport. may also be required for some polarization process involved in dendrite formation.
5457	mediates transcriptional repression by certain nuclear receptors. part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.
5458	
5459	stimulates specifically the gtpase activity of ypt6.
5460	
5461	
5462	
5463	stabilizes the cyclin h-cdk7 complex to form a functional cdk-activating kinase (cak) enzymatic complex. cak activates the cyclin-associated kinases cdc2/cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation. cak complexed to the core-tfiih basal transcription factor activates rna polymerase ii by serine phosphorylation of the repetitive c-terminus domain (ctd) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts. involved in cell cycle control and in rna transcription by rna polymerase ii.
5464	
5465	
5466	
5467	
5468	
5469	
5470	
5471	
5472	
5473	
5474	caspase-like protease, which plays a central role in the chromosome segregation by cleaving the scc1/rad21 subunit of the cohesin complex at the onset of anaphase. during most of the cell cycle, it is inactivated by different mechanisms.
5475	acts as a sequence specific dna binding transcriptional activator or repressor. the isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. may be required in conjunction with tp73/p73 for initiation of tp53/p53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. involved in notch signaling by probably inducing jag1 and jag2. plays a role in the regulation of epithelial morphogenesis. the ratio of deltan-type and ta*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. required for limb formation from the apical ectodermal ridge.
5476	
5477	receptor for atrial natriuretic peptide. does not have guanylate cyclase activity.
5478	
5479	
5480	may function in membrane trafficking. exhibits calcium- dependent phospholipid binding properties (by similarity). may have a role in synaptic plasticity.
5481	involved in gonadal development (by similarity).
5482	
5483	
5484	
5485	
5486	
5487	
5488	may be involved in transcriptional regulation.
5489	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
5490	
5491	may play a role in neuron-specific rna processing.
5492	l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists.
5493	negative regulator of the heat shock response. negatively affects hsf1 dna-binding activity. may have a role in the suppression of the activation of the stress response during the aging process.
5494	transports ca(2+) in exchange for either li(+) or na(+), explaining how li(+) catalyzes ca(2+) exchange. in contrast to other members of the family its function is independent of k(+).
5495	
5496	converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. may function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes.
5497	
5498	
5499	
5500	
5501	
5502	probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. can be blocked by extracellular barium or cesium.
5503	receptor for msh (alpha, beta and gamma) and acth. the activity of this receptor is mediated by g proteins which activate adenylate cyclase.
5504	
5505	putative atp-dependent rna helicase.
5506	required for protein transport from the er to the golgi complex.
5507	integrin alpha-l/beta-2 is a receptor for icam1, icam2, icam3 and icam4. integrins alpha-m/beta-2 and alpha-x/beta-2 are receptors for the ic3b fragment of the third complement component and for fibrinogen. integrin alpha-x/beta-2 recognizes the sequence g-p-r in fibrinogen alpha-chain. integrin alpha-m/beta-2 recognizes p1 and p2 peptides of fibrinogen gamma chain. integrin alpha-m/beta-2 is also a receptor for factor x. integrin alpha- d/beta-2 is a receptor for icam3 and vcam1.
5508	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.
5509	
5510	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
5511	plays an important role in the degradation of some oligopeptides.
5512	
5513	cytokine that inhibits the activity of bmp2 and bmp4 in a dose-dependent manner. antagonized bmp4-induced suppression of progesterone production in granulosa cells (by similarity).
5514	
5515	
5516	
5517	inhibits factor x (x(a)) directly and, in a xa-dependent way, inhibits viia/tissue factor activity, presumably by forming a quaternary xa/laci/viia/tf complex. it possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
5518	
5519	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
5520	
5521	
5522	
5523	
5524	may have direct activity on the actin cytoskeleton. induces actin polymerization and redistribution. contributes with nck1 and grb2 in the recruitment and activation of wasl. may participate in regulating the subcellular localization of wasl, resulting in the disassembly of stress fibers in favor of filopodia formation (by similarity). plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting wasl to vaccinia virus.
5525	
5526	mediator of diverse signals that repress rna polymerase iii transcription. inhibits the de novo assembly of tfiiib onto dna (by similarity).
5527	redirects newly synthesized mhc class i heavy chains via the sec61 translocon to the cytosol where they undergo proteasome- dependent destruction. in consequence, infected cells are masked for immune recognition by cytotoxic t-lymphocytes.
5528	
5529	
5530	
5531	
5532	promotes the exchange of ras-bound gdp by gtp.
5533	part of a post-splicing multiprotein complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. associates preferentially with mrnas produced by splicing. does not interact with pre-mrnas, introns, or mrnas produced from intronless cdnas. associates with both nuclear mrnas and newly exported cytoplasmic mrnas. complex with magoh is a component of the nonsense mediated decay (nmd) pathway.
5534	
5535	involved in the biosynthesis of gangliosides gm2, gd2 and ga2.
5536	
5537	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (by similarity).
5538	
5539	type x collagen is a product of hyperthrophic chondrotocytes and has been localized to presumptive mineralization zones of hyaline cartilage.
5540	sodium-independent transporter of chloride and iodide.
5541	functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit kpnb1. acting autonomously, is thought to serve itself as receptor for nuclear localization signals (nls) and to promote translocation of import substrates through the nuclear pore complex (npc) by an energy requiring, ran-dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. mediates autonomously the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in association with kpnb1 mediates the nuclear import of h1 histone and the ran-binding site of ipo7 is not required but synergizes with that of kpnb1 in importin/substrate complex dissociation. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones. in vitro, mediates the nuclear import of hiv-1 reverse transcription complex (rtc) integrase.
5542	phosphorylase is an important allosteric enzyme in carbohydrate metabolism. enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. however, all known phosphorylases share catalytic and structural properties.
5543	
5544	may participate in forming intercisternal cross-bridges of the golgi complex.
5545	putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. preferentially binds to alpha2,6-linked sialic acid. the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. in the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their sh2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. induces apoptosis in acute myeloid leukemia (in vitro).
5546	
5547	protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function.
5548	
5549	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
5550	produces atp from adp in the presence of a proton gradient across the membrane. the beta chain is the catalytic subunit.
5551	receptor for glutamate. the activity of this receptor is mediated by a g-protein that inhibits adenylate cyclase activity. may mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
5552	specifically binds to the upstream regulatory region of type i ifn and ifn-inducible mhc class i genes (the interferon consensus sequence (ics)). plays a negative regulatory role in cells of the immune system.
5553	activates e box-dependent transcription in collaboration with tcf3/e47, but the activity is completely antagonized by the negative regulator of neurogenesis hes1. may play a role in the differentiation of subsets of neural cells by activating e box- dependent transcription (by similarity).
5554	
5555	
5556	down-regulates the expression of several chemokine receptors. interferes with hiv-1 replication by suppressing tat- induced viral ltr promoter activity.
5557	implicated in the control of cell fate decisions during development.
5558	
5559	the gpib-v-ix complex functions as the von willebrand factor receptor and mediates von willebrand factor-dependent platelet adhesion to blood vessels. the adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. gp-ix may provide for membrane insertion and orientation of gp-ib.
5560	
5561	
5562	
5563	involved in transcriptional activation and repression of select genes by chromatin remodelling (alteration of dna- nucleosome topology). required for the coactivation of estrogen responsive promoters by swi/snf complexes and the src/p160 family of histone acetyltransferases (hats). also specifically interacts with the corest corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.
5564	
5565	
5566	
5567	
5568	
5569	
5570	
5571	
5572	component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. has a role in the correct positioning of the septum. required for anchoring mad2l1 to the nuclear periphery.
5573	
5574	
5575	transport of phosphorylated lysosomal enzymes from the golgi complex and the cell surface to lysosomes. lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low ph mediates the dissociation of the complex. this receptor also binds igf2.
5576	
5577	
5578	acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (by similarity). causes reduced proliferation of b-lymphocytes.
5579	integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis.
5580	
5581	involved in regulation of actin cytoskeleton organization and endocytosis.
5582	required for protein transport from the er to the golgi complex.
5583	
5584	may function as an adapter molecule that regulates traf3-mediated jnk activation (by similarity).
5585	adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. may link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. may play a role in the regulation of secretory granules via its interaction with ptprn.
5586	associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mrna splicing.
5587	plays an important role in the degradation of dermatan and keratan sulfates.
5588	may bind dna (by similarity).
5589	
5590	ppiases accelerate the folding of proteins during protein synthesis.
5591	
5592	
5593	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
5594	
5595	
5596	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
5597	
5598	
5599	
5600	
5601	
5602	
5603	involved in the replication of mitochondrial dna.
5604	
5605	
5606	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
5607	gtpase-activating protein for the adp ribosylation factor family.
5608	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb.
5609	
5610	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
5611	
5612	
5613	
5614	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
5615	involved in the transport of chloride ions. may regulate bicarbonate secretion and salvage in epithelial cells by regulating the slc4a7 transporter.
5616	muscle contraction.
5617	
5618	
5619	
5620	
5621	may play a role in the regulation of sterol metabolism. binds a range of oxysterols.
5622	may be a regulated effector of stress granule assembly. phosphorylation-dependent sequence-specific endoribonuclease in vitro. cleaves exclusively between cytosine and adenine and cleaves c-myc mrna preferentially at the 3@#$%&utr. atp- and magnesium-dependent helicase. unwinds preferentially partial dna and rna duplexes having a 17 bp annealed portion and either a hanging 3@#$%& tail or hanging tails at both 5@#$%& and 3@#$%& ends. unwinds dna/dna, rna/dna, and rna/rna substrates with comparable efficiency. acts unidirectionally by moving in the 5@#$%& to 3@#$%& direction along the bound single-stranded dna.
5623	the smn complex plays an essential role in spliceosomal snrnp assembly in the cytoplasm and is required for pre-mrna splicing in the nucleus. it may also play a role in the metabolism of snornps.
5624	component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. three proteases; ndl, gd and snk process easter to create active easter. active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the tl receptor in the ventral region of the embryo. promotes heterophilic cellular adhesion. spz c-106 in the hemolymph controls expression of the antifungal peptide drosomycin (drs) by acting as a ligand of tl and inducing an intracellular signaling pathway.
5625	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
5626	
5627	
5628	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
5629	regulator of notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. probably acts both as a positive and negative regulator of notch, depending on the developmental and cell context (by similarity). functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the notch pathway via some ubiquitin ligase activity.
5630	
5631	
5632	
5633	
5634	
5635	
5636	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. binds the 7s rna only in presence of srp68. this ribonucleoprotein complex might interact directly with the docking protein in the er membrane and possibly participate in the elongation arrest function.
5637	
5638	
5639	probable transcription regulator.
5640	probable transcription regulator.
5641	catalyzes the exchange of adp and atp across the mitochondrial inner membrane. may participate in the formation of the permeability transition pore complex (ptpc) responsible for the release of mitochondrial products that triggers apoptosis.
5642	catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of nadph.
5643	
5644	involved in recruiting unphosphorylated forms of smad2/smad3 to the tgf-beta receptor by controlling their subcellular localization and by interacting and colocalizing with the tgf-beta receptor. phosphorylation of smad2/smad3 induces dissociation from zfyve9 and formation of smad2/smad4 complexes and nuclear translocation.
5645	
5646	
5647	may play a role in the control of gene expression.
5648	ena/vasp proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodelling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. enah induces the formation of f-actin rich outgrowths in fibroblasts. acts syngeristically with baiap2alpha and downstream of ntn1 to promote filipodia formation. required for the actin-based mobility of listeria monocytogenes (by similarity).
5649	
5650	
5651	promotes the exchange of ras-bound gdp by gtp.
5652	
5653	
5654	component of the u3 small nucleolar ribonucleoprotein. required for the early cleavages at sites a0, a1 and a2 during 18s ribosomal pre-rna processing.
5655	
5656	
5657	
5658	orphan receptor that binds dna as a monomer to hormone response elements (hre) containing an extended core motif half- site sequence 5@#$%&-aaggtca-3@#$%& in which the 5@#$%& flanking nucleotides participate in determining receptor specificity. may be required for brain development. may be involved in the regulation of retinal development (by similarity).
5659	
5660	
5661	may play a role in the regulation of rna biogenesis and/or mitosis. in vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone h1.
5662	component of cohesin complex, a complex required for the cohesion of sister chromatids after dna replication. the cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. at anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. the cohesin complex may also play a role in spindle pole assembly during mitosis.
5663	may play an important role in ckii- and p60c-src-induced signal transduction cascades (by similarity).
5664	
5665	isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
5666	
5667	
5668	
5669	
5670	may be involved in transcriptional regulation.
5671	fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
5672	
5673	
5674	may play a role in telomeric silencing. acetylates soluble but not nucleosomal h4 at lys-5 and lys-12 and acetylates histone h2a at lys-5. hat1 has intrinsic substrate specificity that modifies lysine in recognition sequence gxgkxg.
5675	
5676	
5677	
5678	
5679	
5680	transcriptional repressor.
5681	
5682	
5683	
5684	
5685	
5686	
5687	involved in the assembly or repair of the [fe-s] clusters present in iron-sulfur proteins. binds iron.
5688	
5689	
5690	
5691	
5692	
5693	
5694	binds to and inhibits the transcriptional repressor zbtb33, which may lead to activation of target genes of the wnt signaling pathway (by similarity). may associate with and regulate the cell adhesion properties of both c- and e-cadherins. implicated both in cell transformation by src and in ligand- induced receptor signaling through the egf, pdgf, csf-1 and erbb2 receptors.
5695	
5696	receptor for glutamate. l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists. this receptor binds ampa(quisqualate) > glutamate > kainate.
5697	may be involved in tissue injury and remodeling. has significant elastolytic activity. can accept large and small amino acids at the p1@#$%& site, but has a preference for leucine. aromatic or hydrophobic residues are preferred at the p1 site, with small hydrophobic residues (preferably alanine) occupying p3.
5698	mediates the nuclear export of aminoacylated trnas. in the nucleus binds to trna and to the gtpase ran in its active gtp- bound form. docking of this trimeric complex to the nuclear pore complex (npc) is mediated through binding to nucleoporins. upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of ran-gtp to ran-gdp (induced by ranbp1 and rangap1, respectively) cause release of the trna from the export receptor. xpot then return to the nuclear compartment and mediate another round of transport. the directionality of nuclear export is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus.
5699	receptor for prostacyclin (prostaglandin i2 or pgi2). the activity of this receptor is mediated by g(s) proteins which activate adenylate cyclase.
5700	
5701	
5702	
5703	
5704	may be involved in collagen fiber assembly (by similarity).
5705	component of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends. also a component of rnase mrp.
5706	
5707	acts as dominant repressor towards other family members. inhibits nf-kappa-b-regulated gene expression. may be required for the initiation and maintenance of the differentiated state.
5708	
5709	
5710	
5711	
5712	
5713	the ube2v2/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through lys- 63. this type of poly-ubiquitination does not lead to protein degradation by the proteasome. mediates transcriptional activation of target genes. plays a role in the control of progress through the cell cycle and differentiation. plays a role in the error-free dna repair pathway and contributes to the survival of cells after dna damage.
5714	
5715	
5716	
5717	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
5718	
5719	
5720	
5721	
5722	
5723	
5724	
5725	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (by similarity). has angiogenic inhibitor activity. active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture.
5726	
5727	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
5728	
5729	
5730	binds to regulatory subunit (rii) of protein kinase a. may be involved in establishing polarity in signaling systems or in integrating pka-rii isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by camp (by similarity).
5731	this protein may be involved in b-cell activation. may also be involved in signal transduction and gene regulation.
5732	
5733	gtpase-activating protein for rhoa, and perhaps for cdc42. may be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. acts a tumor suppressor in hepatocellular carcinoma cells.
5734	
5735	
5736	
5737	
5738	transcriptional corepressor that binds to a number of transcription factors. inhibits the transcriptional activation mediated by ctnnb1 and tcf family members in wnt signaling. the effects of full-length tle family members may be modulated by association with dominant-negative aes (by similarity).
5739	
5740	cell surface receptor for reelin (reln) and apolipoprotein e (apoe)-containing ligands. lrp8 participates in transmitting the extracellular reelin signal to intracellular signaling processes, by binding to dab1 on its cytoplasmic tail. reelin acts via both the vldl receptor (vldlr) and lrp8 to regulate dab1 tyrosine phosphorylation and microtubule function in neurons. lrp8 has higher affinity for reelin than vldlr. lrp8 is thus a key component of the reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. binds the endoplasmic reticulum resident receptor-associated protein (rap). binds dimers of beta 2-glycoprotein i and may be involved in the suppression of platelet aggregation in the vasculature. highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (phgpx), two proteins required for sperm maturation. may also function as an endocytic receptor.
5741	
5742	receptor for the mip-3-beta chemokine. probable mediator of ebv effects on b-lymphocytes or of normal lymphocyte functions.
5743	important in cell-cell recognition. appears to function in leukocyte-endothelial cell adhesion. interacts with the beta-1 integrin vla4 on leukocytes, and mediates both adhesion and signal transduction. the vcam1/vla4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
5744	
5745	necessary for efficient rna polymerase ii transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by s-ii allows the resumption of elongation from the new 3@#$%&terminus.
5746	
5747	
5748	
5749	
5750	
5751	
5752	
5753	
5754	
5755	
5756	
5757	
5758	
5759	enhances dna synthesis and may play a role in cell proliferation.
5760	
5761	major keratinocyte cell envelope protein.
5762	actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (by similarity).
5763	docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. may function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. may play an important role in integrin beta-1 or b cell antigen receptor (bcr) mediated signaling in b- and t-cells. integrin beta-1 stimulation leads to recruitment of various proteins including crk, nck and shptp2 to the tyrosine phosphorylated form.
5764	
5765	
5766	inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. may mediate the inhibitory effect of rac1 on endocytosis.
5767	
5768	
5769	
5770	
5771	plays a role in signal transduction in blood cells. contributes to both cell proliferation and survival and thus provide a selective advantage in tumorigenesis. may affect the structure or silencing of chromatin by phosphorylating hp1 gamma/cbx3.
5772	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
5773	muscle contraction.
5774	
5775	
5776	biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
5777	guanine nucleotide exchange factor that potentially links pathways that signal through rac1, rhoa and cdc42. catalyzes guanine nucleotide exchange on rhoa and cdc42 and interacts specifically with the gtp-bound form of rac1, suggesting that it functions as an effector of rac1. may also participate in axonal transport in the brain. becomes activated and highly tumorigenic by truncation of the n-terminus.
5778	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1e gives rise to r-type calcium currents. r-type calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group and are blocked by nickel, and partially by omega-agatoxin-iiia (omega-aga-iiia). they are however insensitive to dihydropyridines (dhp), omega- conotoxin-gvia (omega-ctx-gvia), and omega-agatoxin-iva (omega- aga-iva). calcium channels contaning alpha-1e subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
5779	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. psma2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.
5780	
5781	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
5782	
5783	
5784	
5785	gtpase that associates with pre-60s ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (by similarity).
5786	
5787	
5788	factor h functions as a cofactor in the inactivation of c3b by factor i and also increases the rate of dissociation of the c3bbb complex (c3 convertase) and the (c3b)nbb complex (c5 convertase) in the alternative complement pathway.
5789	
5790	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
5791	
5792	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
5793	
5794	involved in several cell fate decisions that require cell-cell interactions. it is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10.
5795	
5796	
5797	
5798	renin is a highly specific endopeptidase, whose only known function is to generate angiotensin i from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
5799	receptor for the fc region of complexed or aggregated immunoglobulins gamma. low affinity receptor. involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by b- cells. binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on b-cells (bcr), t-cells (tcr) or via another fc receptor. isoform iib1 fails to mediate endocytosis or phagocytosis. isoform iib2 does not trigger phagocytosis.
5800	
5801	
5802	phosphorylates ptdins, ptdins4p and ptdins(4,5)p2 with a preference for ptdins(4,5)p2.
5803	troponin t is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin atpase activity.
5804	
5805	stimulates the kinase activity of stk38l.
5806	
5807	
5808	
5809	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
5810	binds to gt and gc boxes promoters elements. probable transcriptional activator.
5811	also acts as a tumor suppressor.
5812	negatively modulates the dna binding activity of oct-2 and therefore its transcriptional regulatory activity. could act either by binding to dna octamer or by interacting with oct-2. may also be a modulator of other octamer-binding proteins.
5813	closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. displays potent endoprotease activity against fibrinogen at acid ph. may play an important role in extracellular matrix degradation.
5814	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
5815	
5816	
5817	may be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
5818	
5819	present throughout the cell cycle, associates with centromeres at early prophase, and remains associated with the centromere until after telophase (by similarity).
5820	may play a role in regulating the early events of spermatogenesis by binding newly synthesized histones variants and transporting them to the nucleus.
5821	required for high-affinity binding to nerve growth factor (ngf), neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor (bdnf). known substrates for the trk receptors are shc1, pi 3-kinase, and plc-gamma-1. has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. activates erk1 by either shc1- or plc-gamma-1-dependent signaling pathway.
5822	
5823	
5824	
5825	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules (by similarity).
5826	
5827	
5828	involved in tolerance to glucose starvation. phosphorylates atm.
5829	
5830	
5831	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. lamin a and c are present in equal amounts in the lamina of mammals.
5832	
5833	has chymotrypsin-type protease activity and hypocalcemic activity.
5834	type i collagen is a member of group i collagen (fibrillar forming collagen).
5835	
5836	may play an important role in cell fate determination during lung development and in spermatogenesis (by similarity).
5837	coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (s300-ii) stimulates initiation of transcription. binds to both direct repeats and palindromes of the 5@#$%&-aggtca-3@#$%& motif.
5838	
5839	binds the poly(a) tail of mrna.
5840	
5841	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.
5842	
5843	
5844	may play a role in promoting maturation and morphological differentiation of cerebellar neurons.
5845	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters. represses transcription from promoters with atf sites. it may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
5846	
5847	binds and is activated by neuregulins and ntak.
5848	muscle contraction.
5849	binds to and activates slc9a1/nhe1 in a serum- independent manner, thus increasing ph and protecting cells from serum deprivation-induced death.
5850	
5851	
5852	
5853	involved in cell motility. when hyaluronan binds to hmmr, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. may also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (erk) activity.
5854	
5855	tfiif is a general transcription initiation factor that binds to rna polymerase ii and helps to recruit it to the initiation complex in collaboration with tfiib. it promotes transcription elongation. this subunit shows atp-dependent dna- helicase activity.
5856	
5857	
5858	may play a role in the control of gene expression.
5859	
5860	orphan receptor. the activity of this receptor is mediated by g proteins which activate adenylate cyclase.
5861	may promote functional cell surface expression of olfactory receptors.
5862	
5863	
5864	collagen type iii occurs in most soft connective tissues along with type i collagen.
5865	capable of removing ubiquitin from ubiquitinated proteins; also capable of removing nedd8 from nedd8 conjugates but has no effect on sentrin-1 conjugates.
5866	
5867	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
5868	
5869	involved in the presentation of foreign antigens to the immune system.
5870	
5871	
5872	transcriptional repressor that binds specifically to the prdi element in the promoter of the beta-interferon gene. drives the maturation of b-lymphocytes into ig secreting cells.
5873	may play a role in the response to environmental stress. appears to act upstream of the jun n-terminal pathway.
5874	involved in skeletal muscle regeneration, specifically at the onset of cell fusion. also involved in macrophage-derived giant cells (mgc) and osteoclast formation from mononuclear precursors (by similarity).
5875	
5876	binds to the fc region of immunoglobulins gamma. high affinity receptor.
5877	may be involved in several stages of intracellular trafficking (by similarity).
5878	
5879	tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
5880	
5881	
5882	
5883	orphan receptor.
5884	
5885	
5886	probably acts as a co-chaperone (by similarity).
5887	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
5888	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. the produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
5889	associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mrna splicing.
5890	
5891	
5892	
5893	may play a role in cell-cell and cell-matrix interactions. this is a non-catalytic metalloprotease-like protein.
5894	potential tumor suppressor. acts as a phosphoinositide 3-phosphatase by regulating ptdins(3,4,5)p3 levels. involved in regulation of the akt1 signaling pathway. the unphosphorylated form cooperates with aip1 to suppress akt1 activation.
5895	
5896	
5897	
5898	
5899	seems to be required for maximal rate of protein biosynthesis. enhances ribosome dissociation into subunits and stabilizes the binding of the initiator met-trna(i) to 40 s ribosomal subunits.
5900	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
5901	inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin a. could play a role during central nervous system development (by similarity).
5902	protein kinase that is involved in mitotic regulation. may have a role at the g2-m transition. may also play a role in meiosis. isoform 1 but not isoform 2 appears to play a role in centrosome splitting. isoform 1 phosphorylates and activates nek11 in g1/s-arrested cells. isoform 2, which is not present in the nucleolus, does not.
5903	suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. regulates cell death by controlling the mitochondrial membrane permeability. appears to function in a feedback loop system with caspases. inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1).
5904	splicing factor that in its dephosphorylated form acts as a general repressor of pre-mrna splicing. seems to interfere with the u1 snrnp 5@#$%&-splice recognition of snrp70. required for splicing repression in m-phase cells and after heat shock. may be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
5905	
5906	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form.
5907	
5908	
5909	
5910	plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. stimulates water drinking and food intake. may play a role in the hypothalamic response to stress (by similarity). npw23 activates gpr7 and gpr8 more efficiently than npw30.
5911	
5912	
5913	calcium channel protein which plays an important role in excitation-contraction coupling.
5914	binds igf-i and igf-ii with a relatively low affinity. stimulates prostacyclin (pgi2) production.
5915	
5916	
5917	probable role in regulating transcription of specific genes. may regulate through nfkb1 the expression of the ccl2/mcp-1 chemokine. may play a role in tumor necrosis factor alpha (tnf- alpha) gene expression.
5918	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. interacts with receptor-regulated smads specific for the bmp pathway, smad1 and smad5, in order to trigger their ubiquitination and degradation and hence their inactivation.
5919	may be involved in transcriptional regulation.
5920	essential for transcriptional activity of the hla class ii promoter; activation is via the proximal promoter. no dna binding of in vitro translated ciita was detected. may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal mhc class ii promoter, to elements of the transcription machinery, or both. alternatively it may activate hla class ii transcription by modifying proteins that bind to the mhc class ii promoter.
5921	forms a high-affinity link between the actin cytoskeleton and the membrane. isoform 2 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation.
5922	may be involved in chromatin remodeling and transcriptional regulation. may have a role in x inactivation.
5923	part of the insoluble cornified cell envelope (ce) of stratified squamous epithelia.
5924	
5925	component of the polycomb group (pcg) multiprotein prc1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including hox genes, throughout development. pcg prc1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone h2a lys-119, rendering chromatin heritably changed in its expressibility.
5926	arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
5927	
5928	protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. they compact sperm dna into a highly condensed, stable and inactive complex.
5929	
5930	may overlap in function with tropomyosin and may be involved in organization of actin filaments. acts as a multicopy suppressor of rho3 mutation. rna-binding protein which may modulate mrna translation. involved in heme regulation of hap1, as a component of the high-molecular-weight complex (hmc).
5931	
5932	
5933	
5934	
5935	may be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.
5936	
5937	
5938	
5939	plays a role in t-cell proliferation and differentiation.
5940	
5941	
5942	type i collagen is a member of group i collagen (fibrillar forming collagen).
5943	
5944	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
5945	collagen type iii occurs in most soft connective tissues along with type i collagen.
5946	orphan receptor.
5947	
5948	receptor showing broad specificity for both classical and nonclassical mhc class i molecules.
5949	
5950	
5951	downstream regulator in the wnt/frizzled-signaling pathway. associated with cell survival. attenuates p53-mediated apoptosis in response to dna damage through activation of akt kinase. up-regulates the anti-apoptotic bcl-x(l) protein. adheres to skin and melanoma fibroblasts. in vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.
5952	involved in the production of gd3 and gt3 from gm3.
5953	
5954	
5955	confers strong transcriptional repression to the ap- 2alpha gene. binds to a regulatory element (a32) in the ap-2alpha gene promoter.
5956	
5957	
5958	
5959	
5960	putative atp-dependent protease.
5961	catalyzes the n-oxidation of certain primary alkylamines to their oximes via an n-hydroxylamine intermediate. inactive toward certain tertiary amines, such as imipramine or chloropromazine. can catalyze the s-oxidation of methimazole. the truncated form is catalytically inactive.
5962	involved in neurogenesis. also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (by similarity).
5963	may function in cell cycle regulation.
5964	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb (by similarity).
5965	
5966	
5967	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes and then transfers it to substrates (by similarity).
5968	
5969	
5970	
5971	
5972	may play a role in the regulation of psen2 proteolytic processing and apoptosis. together with psen2 involved in modulation of beta-amyloid formation.
5973	appears to have dual functions such as cytoplasmic retention of attached nf-kappa-b proteins and generation of p50 by a cotranslational processing. the proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of nfkb1/p105 also appears to occur posttranslationally. p50 binds to the kappa-b consensus sequence 5@#$%&-ggrnnyycc-3@#$%&, located in the enhancer region of genes involved in immune response and acute phase reactions. plays a role in the regulation of apoptosis.
5974	receptor for vegfc. has a tyrosine-protein kinase activity.
5975	
5976	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
5977	
5978	
5979	converts lysophosphatidic acid (lpa) into phosphatidic acid by incorporating acyl moiety at the 2 position (by similarity).
5980	
5981	
5982	
5983	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release.
5984	
5985	
5986	
5987	
5988	may be involved in the initiation of hepatocyte growth (by similarity).
5989	may play an important role during the embryonic development and differentiation of the central nervous system.
5990	
5991	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
5992	
5993	transcription factor that binds to the enhancer element pre-i (positive regulatory element-i) of the il-4 gene. might change the dna-binding specificity of other transcription factors and recruit them to unusual dna sites.
5994	
5995	
5996	
5997	
5998	orphan receptor.
5999	
6000	
6001	
6002	
6003	this is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. catalyzes the rate-limiting conversions of tyrosine to dopa, dopa to dopa-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
6004	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. has a sulfatase activity.
6005	
6006	ph-dependent, voltage-insensitive, background potassium channel protein. rectification direction results from potassium ion concentration on either side of the membrane. acts as an outward rectifier when external potassium concentration is low. when external potassium concentration is high, current is inward.
6007	participates in the synthesis of thyroid hormones. transfers electrons from adrenodoxin reductase to the cholesterol side chain cleavage cytochrome p450.
6008	
6009	
6010	required for preprotein translocation (by similarity).
6011	required for preprotein translocation (by similarity).
6012	
6013	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
6014	thought to regulate cation conductance. may regulate accn1 and accn3 gating (by similarity).
6015	
6016	
6017	binds directly to 26s ribosomal rna (by similarity).
6018	
6019	
6020	mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. also required for the transfer of beta-barrel precursors from the tom complex to the sorting and assembly machinery (sam complex) of the outer membrane. acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. the timm8-timm13 complex mediates the import of proteins such as timm23, slc25a12/aralar1 and slc25a13/aralar2, while the predominant timm9-timm10 70 kda complex mediates the import of much more proteins. probably necessary for normal neurologic development.
6021	receptor for the fc region of complexed immunoglobulins gamma. low affinity receptor.
6022	
6023	
6024	
6025	
6026	
6027	
6028	
6029	calcium-binding protein required for t-cell receptor-, fas-, and glucocorticoid-induced cell death. may mediate ca(2+)- regulated signals along the death pathway (by similarity).
6030	transcription activator that binds dna cooperatively with dp proteins through the e2 recognition site, 5@#$%&-tttc[cg]cgc- 3@#$%& found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the drtf1/e2f complex functions in the control of cell-cycle progression from g1 to s phase. e2f-3 binds specifically to rb1 protein, in a cell-cycle dependent manner.
6031	
6032	
6033	
6034	
6035	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
6036	binds to regulatory subunit (rii) of protein kinase a. may be involved in establishing polarity in signaling systems or in integrating pka-rii isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by camp (by similarity).
6037	required for protein transport from the er to the golgi complex.
6038	involved in the activation cascade of caspases responsible for apoptosis execution. cleaves caspase-1.
6039	
6040	probable transcription regulator.
6041	involved in the activation cascade of caspases responsible for apoptosis execution. cleaves caspase-1.
6042	serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (dsbs), apoptosis and genotoxic stresses such as ionizing ultraviolet a light (uva), thereby acting as a dna damage sensor. recognizes the substrate consensus sequence [s/t-q]. phosphorylates ser-139 of histone variant h2ax/h2afx at double strand breaks (dsbs), thereby regulating dna damage response mechanism. also involved in signal transduction and cell cycle control. may function as a tumor suppressor. necessary for activation of abl1 and sapk. phosphorylates p53/tp53, fancd2, nfkbia, brca1, ctip, nibrin (nbn), terf1, rad9 and dclre1c. may play a role in vesicle and/or protein transport. could play a role in t-cell development, gonad and neurological function.
6043	
6044	
6045	receptor for hepatocyte growth factor and scatter factor. has a tyrosine-protein kinase activity.
6046	
6047	
6048	
6049	
6050	
6051	may be required for ribosome biogenesis.
6052	angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
6053	class e vps protein involved in concentration and sorting of cargo proteins of the multivesicular body (mvb) for incorporation into intralumenal vesicles. fusion between endosomes and the vacuole will then target the cargo proteins to the vacuolar lumen. acts as an adapter that recruits the doa4 deubiquitinase to the endosomes, leading to deubiquitination of cargo proteins prior to the lumenal sequestration. its association to the endosomes depends on snf7 and its dissociation requires vps4. interacts functionally with the pkc1p-mitogen-activated protein kinase pathway.
6054	
6055	may be involved in transcriptional regulation.
6056	
6057	
6058	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
6059	
6060	
6061	
6062	in vitro, acts as a receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5).
6063	
6064	
6065	modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. may play a role in synapse formation during brain development.
6066	
6067	
6068	
6069	
6070	may catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of vim-2, lewis a, lewis b, sialyl lewis x and lewis x/ssea-1 antigens. may be involved in blood group lewis determination; lewis-positive (le(+)) individuals have an active enzyme while lewis-negative (le(-)) individuals have an inactive enzyme.
6071	
6072	muscle contraction.
6073	paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.
6074	catalyzes the posttranslational formation of 4- hydroxyproline in hypoxia-inducible factor (hif) alpha proteins. hydroxylates hif-1 alpha at pro-564, and hif-2 alpha. functions as a cellular oxygen sensor and, under normoxic conditions, targets hif through the hydroxylation for proteasomal degradation via the von hippel-lindau ubiquitination complex. may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. promotes cell death through a caspase-dependent mechanism (by similarity).
6075	
6076	
6077	
6078	type i collagen is a member of group i collagen (fibrillar forming collagen).
6079	
6080	during lymphocyte development, the genes encoding immunoglobulins and t-cell receptors are assembled from variable (v), diversity (d), and joining (j) gene segments. this combinatorial process, known as v(d)j recombination, allows the generation of an enormous range of binding specificities from a limited amount of genetic information. the rag1/rag2 complex initiates this process by binding to the conserved recombination signal sequences (rss) and introducing a double-strand break between the rss and the adjacent coding segment. these breaks are generated in two steps, nicking of one strand (hydrolysis), followed by hairpin formation (transesterification). rag1/2 has also been shown to function as a transposase in vitro, and to possess rss-independent endonuclease activity (end processing) and hairpin opening. rag1 alone can bind to rss but stable, efficient binding requires rag2. all known catalytic activities require the presence of both proteins.
6081	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. may play an important role in the destruction of aggrecan in arthritic diseases. could also be a critical factor in the exacerbation of neurodegeneration in alzheimer disease. cleaves aggrecan at the 392-glu-|-ala-393 site.
6082	component of the fact complex, a general chromatin factor that acts to reorganize nucleosomes. the fact complex is involved in multiple processes that require dna as a template such as mrna elongation, dna replication and dna repair. during transcription elongation the fact complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. it facilitates the passage of rna polymerase ii and transcription by promoting the dissociation of one histone h2a-h2b dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of rna polymerase ii. the fact complex is probably also involved in phosphorylation of ser-392 of p53/tp53 via its association with ck2 (casein kinase ii). binds specifically to double-stranded dna and at low levels to dna modified by the antitumor agent cisplatin. may potentiate cisplatin-induced cell death by blocking replication and repair of modified dna. also acts as a transcriptional coactivator for p63/tp73l.
6083	catalyzes the first committed step in the biosynthesis of complex n-glycans. it controls conversion of high mannose to complex n-glycans; the final hydrolytic step in the n-glycan maturation pathway.
6084	
6085	seems to promotes the survival of visceral and proprioceptive sensory neurons.
6086	may function in membrane trafficking. exhibits calcium- dependent phospholipid binding properties (by similarity).
6087	type i collagen is a member of group i collagen (fibrillar forming collagen).
6088	type i collagen is a member of group i collagen (fibrillar forming collagen).
6089	factor h functions as a cofactor in the inactivation of c3b by factor i and also increases the rate of dissociation of the c3bbb complex (c3 convertase) and the (c3b)nbb complex (c5 convertase) in the alternative complement pathway.
6090	
6091	motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport (by similarity).
6092	
6093	
6094	may be involved in signal transduction as a component of a multimeric receptor complex.
6095	
6096	editing of the messenger rnas for glutamate receptor (glur) subunits by site-selective adenosine deamination. edits both the glur-b q/r and r/g sites efficiently but converts the adenosine in hotspot1 much less efficiently.
6097	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. it is suggested that polr2g contributes to the function of rna polymerase ii in the absence of polr2d either in a manner independent of its association with the enzyme or by directly binding to the enzyme in a manner independent of its association with polr2d.
6098	catalyzes the posttranslational addition of a tyrosine to the c-terminal end of detyrosinated alpha-tubulin.
6099	probably involved in the metabolism of xenobiotics and of natural substrates.
6100	
6101	
6102	
6103	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii.
6104	ligand for cd2. might facilitate interaction between activated lymphocytes. probably involved in regulating t-cell activation.
6105	
6106	
6107	
6108	participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
6109	
6110	calcium-dependent mitochondrial solute carrier (by similarity).
6111	catalyzes the covalent attachment of ubiquitin to other proteins. required for postreplication repair of uv-damaged dna. may be involved in neurite outgrowth.
6112	required for anchoring dihydrolipoamide dehydrogenase (e3) to the dihydrolipoamide transacetylase (e2) core of the pyruvate dehydrogenase complexes of eukaryotes. this specific binding is essential for a functional pdh complex.
6113	
6114	
6115	one of the multiple factors required for polyadenylation and 3@#$%&-end cleavage of mammalian pre-mrnas. may be responsible for the interaction of cstf with other factors to form a stable complex on the pre-mrna.
6116	binds specifically and cooperatively to the sph and gt- iic @#$%!enhansons@#$%! (5@#$%&-gtggaatgt-3@#$%&) and activates transcription in vivo in a cell-specific manner. the activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (tif). involved in cardiac development. binds to the m-cat motif.
6117	
6118	
6119	associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mrna splicing (by similarity).
6120	
6121	
6122	
6123	required for protein transport from the er to the golgi complex.
6124	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
6125	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
6126	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
6127	
6128	necessary for the splicing of pre-mrna. it is required for formation of the earliest atp-dependent splicing complex and interacts with spliceosomal components bound to both the 5@#$%& and 3@#$%& splice sites during spliceosome assembly. it also is required for atp-dependent interactions of both u1 and u2 snrnps with pre-mrna (by similarity). can bind to the myelin basic protein (mbp) gene mb3 regulatory region and increase transcription of the mbp promoter in cells derived from the cns.
6129	
6130	
6131	
6132	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
6133	soluble frizzled-related proteins (sfrps) function as modulators of wnt signaling through direct interaction with wnts. they have a role in regulating cell growth and differentiation in specific cell types. sfrp3/frzb appears to be involved in limb skeletogenesis. antagonist of wnt8 signaling. regulates chondrocyte maturation and long bone development.
6134	
6135	
6136	
6137	may play an important role in lipogenesis.
6138	
6139	
6140	
6141	
6142	
6143	camp-dependent and sulfonylurea-sensitive anion transporter. key gatekeeper influencing intracellular cholesterol transport.
6144	could have a role in the budding of coatomer-coated and other species of coated vesicles. could bind cargo molecules to collect them into budding vesicles.
6145	
6146	could have a role in the budding of coatomer-coated and other species of coated vesicles. could bind cargo molecules to collect them into budding vesicles.
6147	
6148	atp-binding rna helicase involved in the biogenesis of 60s ribosomal subunits (by similarity).
6149	putative neuronal cell surface protein involved in cell- cell-interactions.
6150	
6151	produced by activated macrophages, il-1 stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. il-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
6152	
6153	ampk is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-coa carboxylase. also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-coa reductase and hormone- sensitive lipase. this is a regulatory subunit.
6154	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
6155	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
6156	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
6157	
6158	
6159	functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. upon ligand activation through the released notch intracellular domain (nicd) it forms a transcriptional activator complex with rbp-j kappa and activates genes of the enhancer of split locus. affects the implementation of differentiation, proliferation and apoptotic programs. may regulate branching morphogenesis in the developing vascular system (by similarity).
6160	probably function in adherens junction. affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons.
6161	involved in the association of mhc class i with transporter associated with antigen processing (tap) and in the assembly of mhc class i with peptide (peptide loading).
6162	
6163	
6164	
6165	
6166	
6167	core component of nucleosome. nucleosomes wrap and compact dna into chromatin, limiting dna accessibility to the cellular machineries which require dna as a template. histones thereby play a central role in transcription regulation, dna repair, dna replication and chromosomal stability. dna accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodelling.
6168	the ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.
6169	
6170	binds to gc box promoters elements and selectively activates mrna synthesis from genes that contain functional recognition sites. can interact with g/c-rich motifs from serotonin receptor promoter.
6171	
6172	regulates exocytosis in mast cells. increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (by similarity).
6173	may be an activator of the jnk/sapk pathway. phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
6174	
6175	
6176	
6177	involved in repair of uv radiation-induced dna damage. catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same dna strand upon exposure to ultraviolet radiation.
6178	
6179	
6180	
6181	
6182	
6183	required for the expression of several liver specific genes. binds to the inverted palindrome 5@#$%&-gttaatnattaac-3@#$%&.
6184	promotes the exchange of gdp by gtp. may act as part of a signal transduction system linking the catalytic domains of pam in the lumen of the secretory pathway to cytosolic factors regulating the cytoskeleton and signal transduction pathways.
6185	
6186	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. a ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase c has also been reported. it can bind to at least three additional proteins in a ca(2+)-independent manner; these are neurexins, syntaxin and ap2.
6187	
6188	
6189	
6190	required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
6191	
6192	participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. mediates rac1-dependent reorganization of actin filaments. contributes to the activation of pld2 (by similarity).
6193	putative transcription factor.
6194	
6195	
6196	
6197	
6198	
6199	
6200	muscle contraction.
6201	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
6202	
6203	
6204	probable transcription factor binds to the usf/mltf site and probably recognizes e-box sequences in the heavy-chain immunoglobulin enhancer.
6205	may be involved in transcriptional regulation.
6206	
6207	neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. it causes contraction of smooth muscle.
6208	
6209	
6210	may be involved in several stages of intracellular trafficking (by similarity).
6211	
6212	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. may play an important role in renal tubular function.
6213	important negative regulator in hematopoiesis and immune systems; may be involved in ending inflammatory responses through its inhibitory functions. inhibits endothelial nf-kappa-b signaling through a camp-dependent pathway. inhibits tnf-alpha- induced expression of endothelial adhesion molecules. involved in the control of fat metabolism and insulin sensitivity.
6214	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. rna polymerase i is essentially used to transcribe ribosomal dna units.
6215	
6216	
6217	
6218	plays an important role in the regulation of microtubule (mt) dynamics, regulating the density, length distribution and stability of interphase mts. participates in generating polarized mt networks in migrating fibroblasts.
6219	may inhibit both the autophosphorylation of eif2ak2/pkr and the ability of eif2ak2/pkr to catalyze phosphorylation of the eif2a. may inhibit eif2ak3/perk activity (by similarity). co- chaperone of hspa8/hsc70. involved in the unfolded protein response (upr) during er stress. stimulates the atpase activity of hspa8/hsc70.
6220	transcriptional regulator that probably plays an important role in lymphomagenesis.
6221	
6222	has a role in the negative regulation of gluconeogenesis. required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (fbpase).
6223	
6224	cytokine that binds to tnfrsf6/fas, a receptor that transduces the apoptotic signal into cells. may be involved in cytotoxic t-cell mediated apoptosis and in t-cell development. tnfrsf6/fas-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature t-cells, or both. binding to the decoy receptor tnfrsf6b/dcr3 modulates its effects.
6225	
6226	protein transport. probably involved in vesicular traffic (by similarity).
6227	
6228	
6229	
6230	probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. may also participate in functions of the mature nervous system.
6231	promotes apoptosis and activation of nf-kappa-b. required for tnfrsf1a mediated activation of nf-kappa-b.
6232	
6233	
6234	mbp1 binds to the c-myc promoter and acts as a transcriptional repressor. may be a tumor suppressor.
6235	
6236	
6237	not known. binds to the globular @#$%!heads@#$%! of c1q thus inhibiting c1 activation.
6238	
6239	
6240	
6241	
6242	
6243	
6244	
6245	
6246	
6247	
6248	
6249	involved in the control of dna replication.
6250	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
6251	receptor for the tridecapeptide neurotensin. it is associated with g proteins that activate a phosphatidylinositol- calcium second messenger system.
6252	
6253	
6254	
6255	
6256	enhances all basic t-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by b-cells. essential both for efficient interaction between t and b-cells and for normal antibody responses to t-cell dependent antigens. does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. prevents the apoptosis of pre- activated t-cells. plays a critical role in cd40-mediated class switching of immunoglobin isotypes (by similarity).
6257	transcription activator for a number of liver genes such as afp, albumin, tyrosine aminotransferase, pepck, etc. interacts with the cis-acting regulatory regions of these genes.
6258	
6259	
6260	
6261	
6262	
6263	cell surface proteoglycan that bears heparan sulfate. putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (by similarity).
6264	
6265	the beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating g protein inhibition and controlling the alpha-1 subunit membrane targeting.
6266	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
6267	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. may catalyze basal processing of intracellular antigens.
6268	
6269	
6270	
6271	
6272	
6273	reversible hydration of carbon dioxide.
6274	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
6275	
6276	collagen type iv is specific for basement membranes.
6277	part of the snapc complex required for the transcription of both rna polymerase ii and iii small-nuclear rna genes. binds to the proximal sequence element (pse), a non-tata-box basal promoter element common to these 2 types of genes. recruits tbp and brf2 to the u6 snrna tata box.
6278	
6279	
6280	
6281	
6282	able to inhibit growth in several cell lines (by similarity).
6283	forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
6284	
6285	catalyzes a dehydrogenation to introduce c5-6 double bond into lathosterol.
6286	
6287	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex. necessary for h(+) conduction (by similarity).
6288	is able to inhibit all four classes of proteinases by a unique @#$%&trapping@#$%& mechanism. this protein has a peptide stretch, called the @#$%&bait region@#$%& which contains specific cleavage sites for different proteinases. when a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. the entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
6289	stimulatory or required for the translocation of secretory proteins across the er membrane.
6290	histones h1 are necessary for the condensation of nucleosome chains into higher order structures.
6291	monokine with inflammatory and chemokinetic properties. binds to ccr1, ccr4 and ccr5. one of the major hiv-suppressive factors produced by cd8+ t-cells. recombinant mip-1-alpha induces a dose-dependent inhibition of different strains of hiv-1, hiv-2, and simian immunodeficiency virus (siv).
6292	likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. may play a role in the differentiation of spermatozoa and oocytes.
6293	
6294	involved in the presentation of foreign antigens to the immune system.
6295	involved in vitamin d-mediated transcription. can function as a splicing factor in pre-mrna splicing.
6296	essential component of the tim23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
6297	essential component of the tim23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
6298	
6299	
6300	
6301	serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors creb (camp response element-binding protein) and atf1 (activating transcription factor-1). essential role in the control of rela transcriptional activity in response to tnf. directly represses transcription via phosphorylation of ser-1 of histone h2a. mediates the mitogen- and stress-induced phosphorylation of histone h3 and high mobility group protein 14 (hmg-14).
6302	type i collagen is a member of group i collagen (fibrillar forming collagen).
6303	
6304	kinase that can phosphorylate various inositol polyphosphate such as ins(3,4,5,6)p4 or ins(1,3,4)p3. phosphorylates ins(3,4,5,6)p4 at position 1 to form ins(1,3,4,5,6)p5. this reaction is thought to have regulatory importance, since ins(3,4,5,6)p4 is an inhibitor of plasma membrane ca(2+)-activated cl(-) channels, while ins(1,3,4,5,6)p5 is not. also phosphorylates ins(1,3,4)p3 on o-5 and o-6 to form ins(1,3,4,6)p4, an essential molecule in the hexakisphosphate (insp6) pathway. also acts as an inositol polyphosphate phosphatase that dephosphorylate ins(1,3,4,5)p4 and ins(1,3,4,6)p4 to ins(1,3,4)p3, and ins(1,3,4,5,6)p5 to ins(3,4,5,6)p4. may also act as an isomerase that interconverts the inositol tetraphosphate isomers ins(1,3,4,5)p4 and ins(1,3,4,6)p4 in the presence of adp and magnesium. probably acts as the rate-limiting enzyme of the insp6 pathway. modifies tnf-alpha-induced apoptosis by interfering with the activation of tnfrsf1a-associated death domain.
6305	participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. also cleaves alpha-2 macroglobulin. may be involved in osteoblast differenciation and/or osteoblast activity in bone (by similarity).
6306	catalyzes the formation of aromatic c18 estrogens from c19 androgens.
6307	induces sprouting in endothelial cells through an autocrine and paracrine action.
6308	component of the dendritic ribonucleoprotein particles (rnps) in hippocampal neurons. may play a role in mrna transport.
6309	part of the insoluble cornified cell envelope (ce) of stratified squamous epithelia.
6310	
6311	
6312	
6313	plays an important role in the elongation step of protein synthesis.
6314	catalyzes the production of gaba.
6315	this protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. it may constitute the earliest mammalian endothelial cell lineage marker. probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.
6316	
6317	
6318	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
6319	
6320	contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion.
6321	protection of cells from complement-mediated damage (by similarity).
6322	
6323	
6324	
6325	component of the tom (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. together with tom20 and tom22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the tom40 translocation pore.
6326	involved in the replication of mitochondrial dna.
6327	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
6328	
6329	
6330	
6331	c/ebp is a dna-binding protein that recognizes two different motifs: the ccaat homology common to many promoters and the enhanced core homology common to many enhancers.
6332	may be involved in transcriptional regulation.
6333	
6334	
6335	may be involved in peroxisomal proliferation and may regulate peroxisomes division. may mediate binding of coatomer proteins to the peroxisomal membrane.
6336	component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. the nua4 complex atpase and helicase activities seem to be, at least in part, contributed by the association of ruvbl1 and ruvbl2 with ep400. nua4 may also play a direct role in dna repair when directly recruited to sites of dna damage. also component of the msin3a complex which acts to repress transcription by deacetylation of nucleosomal histones.
6337	
6338	phosphorylates microtubule-associated protein 2 (map2). may promote entry in the cell cycle.
6339	
6340	involved in bcr (b-cell antigen receptor)-mediated signaling in b-cells and tcr (t-cell antigen receptor)-mediated t- cell signaling in t-cells. in absence of tcr signaling, may be involved in cd4-mediated inhibition of t-cell activation. couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or mapk activation through the recruitment of plcg2, grb2, grap2, and other signaling molecules.
6341	
6342	
6343	ppiases accelerate the folding of proteins during protein synthesis.
6344	
6345	polymerase that creates the 3@#$%& poly(a) tail of mrna@#$%&s. also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. may acquire specificity through interaction with a cleavage and polyadenylation specificity factor (cpsf) at its c-terminus.
6346	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. has angiogenic inhibitor activity (by similarity). active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture (by similarity).
6347	
6348	
6349	cytokine that binds to tnfrsf1a/tnfr1 and tnfrsf1b/tnfbr. it is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. it is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, under certain conditions it can stimulate cell proliferation and induce cell differentiation.
6350	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
6351	
6352	can activate specifically hydrolysis of gtp bound to rac1 and cdc42, but not rala. mediates atp-dependent transport of s-(2,4-dinitrophenyl)-glutathione (dnp-sg) and doxorubicin (dox) and is the major atp-dependent transporter of glutathione conjugates of electrophiles (gs-e) and dox in erythrocytes. can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon.
6353	in addition to its enzymatic role it could play an important role in the yeast cell morphology.
6354	
6355	plays a role in the inducible expression of genes. regulates hypertonicity-induced cellular accumulation of osmolytes.
6356	activates apoptosis.
6357	possesses rna 5@#$%&-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. binds to rna. may participate in nuclear mrna metabolism.
6358	
6359	
6360	
6361	tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
6362	cooperates with cdc6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate dna replication. binds dna in a sequence-, strand-, and conformation-independent manner. potential oncogene.
6363	candidate for the putative colorectal tumor suppressor gene located at 5q21.
6364	
6365	
6366	may serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. weakly activates the map kinase pathway.
6367	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
6368	collagen type iii occurs in most soft connective tissues along with type i collagen.
6369	required for meiotic chromosome synapsis and cell cycle progression. may act as a molecular zipper to bring homologous chromosomes in close apposition. zip1 may encode the transverse filaments of the synaptonemal complex.
6370	the soluble form is chemotactic for t-cells and monocytes, but not for neutrophils. the membrane-bound form promotes adhesion of those leukocytes to endothelial cells. may play a role in regulating leukocyte adhesion and migration processes at the endothelium. binds to cx3cr1.
6371	tgf alpha is a mitogenic polypeptide that is able to bind to the egf receptor and to act synergistically with tgf beta to promote anchorage-independent cell proliferation in soft agar.
6372	receptor for tnfsf13b/blys/baff and tnfsf13/april. promotes b-cell survival and plays a role in the regulation of humoral immunity. activates nf-kappa-b and jnk.
6373	
6374	type i collagen is a member of group i collagen (fibrillar forming collagen).
6375	
6376	required for the assembly of f-actin structures, such as stress fibers. depends on the rho-rock cascade for its activity. contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation.
6377	
6378	
6379	
6380	
6381	
6382	
6383	
6384	
6385	may be involved in transcriptional regulation.
6386	activates e box-dependent transcription in collaboration with tcf3/e47, but the activity is completely antagonized by the negative regulator of neurogenesis hes1. may play a role in the differentiation of subsets of neural cells by activating e box- dependent transcription (by similarity).
6387	decoy receptor for the cytotoxic ligands tnfs14/light and tnfsf6/fasl. protects against apoptosis.
6388	
6389	
6390	
6391	
6392	enzyme which catalyzes the acetylation of polyamines. substrate specificity: norspermidine = spermidine >> spermine > n(1)acetylspermine > putrescine. this highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. also involved in the regulation of polyamine transport out of cells.
6393	
6394	protein tyrosine phosphatase which stimulates progression from g1 into s phase during mitosis. promotes tumors. inhibits geranylgeranyl transferase type ii activity by blocking the association between rabggta and rabggtb.
6395	
6396	possibly acts as a transcriptional regulatory factor.
6397	catalyzes the reduction of the delta-24 double bond of sterol intermediates. protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. also protects against amyloid-beta peptide-induced apoptosis.
6398	
6399	
6400	
6401	may be involved in the synthesis of gangliosides gd1c, gt1a, gq1b and gt3 from gd1a, gt1b, gm1b and gd3 respectively.
6402	
6403	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
6404	cleaves the glcnac-asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
6405	
6406	muscle contraction.
6407	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
6408	intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate.
6409	probable atp-binding rna helicase involved in pre-mrna splicing.
6410	fibrogenic lymphokine, that stimulates several biological activities related to scarring. stimulates synthesis of extracellular matrix protein like collagen, fibronectin and hyaluronan and fibroblast proliferation. induces chemotaxis of fibroblasts and smooth muscle cells. enhances wound healing and may be involved in accelerating epithelization by acting as direct mitogen and/or a motogen for epithelial cells (by similarity). may play a role in fibrogenesis associated with certain chronic inflammatory diseases.
6411	probable transcriptional factor (by similarity).
6412	
6413	negatively regulates tyrosine hydroxylase activity.
6414	
6415	
6416	required for protein transport from the er to the golgi complex.
6417	
6418	may act as a downstream effector of cdc42 in cytoskeletal reorganization. contributes to the actomyosin contractility required for cell invasion, through the regulation of mypt1 and thus mlc2 phosphorylation (by similarity).
6419	
6420	may play a role in acinar cell metabolism.
6421	may play a role in lipid exchange and transport throughout the body. may participate in reverse cholesterol transport from peripheral cells to the liver (by similarity).
6422	
6423	this is a specific receptor for parathyroid hormone. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase. pthr2 may be responsible for pth effects in a number of physiological systems. it may play a significant role in pancreatic function. pthr2 presence in neurons indicates that it may function as a neurotransmitter receptor (by similarity).
6424	part of the signal peptidase complex (spc), exact function is not known.
6425	
6426	
6427	
6428	catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (spp), a lipid mediator with both intra- and extracellular functions. also acts on d-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as d,l-threo-dihydrosphingosine, n,n-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
6429	
6430	
6431	
6432	this is a membrane-bound, calcium-inhibitable adenylyl cyclase.
6433	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
6434	
6435	
6436	
6437	probable rho/rac effector that binds to the gtp-bound forms of rho and rac1. it probably binds p21 with a tighter specificity in vivo. dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. plays an important role in the regulation of cytokinesis and the development of the central nervous system.
6438	functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. upon ligand activation through the released notch intracellular domain (nicd) it forms a transcriptional activator complex with rbp-j kappa and activates genes of the enhancer of split locus. affects the implementation of differentiation, proliferation and apoptotic programs (by similarity). may regulate branching morphogenesis in the developing vascular system.
6439	serves as the first electron transfer protein in all the mitochondrial p450 systems. including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-oh-vitamin d3-24 hydroxylation in the kidney, and sterol c-27 hydroxylation in the liver.
6440	may be involved in transcriptional regulation.
6441	
6442	reversible hydration of carbon dioxide.
6443	
6444	rab effector protein acting as linker between gamma- adaptin, rab4a and rab5a. involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. stimulates rabgef1 mediated nucleotide exchange on rab5a.
6445	
6446	addition of nucleotide-activated sugars directly onto the polypeptide through o-glycosidic linkage with the hydroxyl of serine or threonine.
6447	the alpha-v integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von willebrand factor. they recognize the sequence r-g-d in a wide array of ligands.
6448	
6449	
6450	
6451	
6452	may play a role in vesicle trafficking.
6453	catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. key enzyme that regulate the activity state of the bckd complex (by similarity).
6454	
6455	binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. may prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
6456	
6457	
6458	secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
6459	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity). overexpression may be associated with abnormal proliferation in human breast tissue.
6460	
6461	enhances nf-kappa-b, srf and ap1 transactivation.
6462	component of the anaphase promoting complex/cyclosome (apc/c), a cell cycle-regulated e3 ubiquitin-protein ligase complex that controls progression through mitosis and the g1 phase of the cell cycle. the apc/c is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating e2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26s proteasome. in early mitosis, the apc/c is activated by cdc20 and targets securin pds1, the b-type cyclin clb5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. in late mitosis and in g1, degradation of clb5 allows activation of the apc/c by cdh1, which is needed to destroy cdc20 and the b-type cyclin clb2 to allow exit from mitosis and creating the low cdk state necessary for cytokinesis and for reforming prereplicative complexes in g1 prior to another round of replication.
6463	
6464	suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. regulates cell death by controlling the mitochondrial membrane permeability. appears to function in a feedback loop system with caspases. inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1).
6465	receptor for extracellular adenine nucleotides such as atp and adp. in platelets binding to adp leads to mobilization of intracellular calcium ions via activation of phospholipase c, a change in platelet shape, and probably to platelet aggregation.
6466	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
6467	weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
6468	
6469	
6470	
6471	thyroid receptor interacting proteins (trips) specifically interact with the ligand binding domain of the thyroid receptor (tr). trip3 requires the presence of thyroid hormone for its interaction.
6472	rna-dependent atpase activity. suppressor of a mutant defective in 50s ribosomal subunit assembly. probably interacts with 23s ribosomal rna.
6473	
6474	
6475	essental for release from glucose repression. it interacts and has functional relationship to the regulatory protein snf4. interacts also with sip1, sip2 and gal83. could phosphorylates cat8.
6476	
6477	
6478	transcriptional repressor involved in developmental processes. probably plays a role in limb pattern formation.
6479	plays a major role in ketone body metabolism.
6480	
6481	part of the snapc complex required for the transcription of both rna polymerase ii and iii small-nuclear rna genes. binds to the proximal sequence element (pse), a non-tata-box basal promoter element common to these 2 types of genes. recruits tbp and brf2 to the u6 snrna tata box.
6482	
6483	
6484	could regulate export of the bud site and axial growth sites selection protein axl2 and possibly other secretory proteins from the endoplasmic reticulum in copii-coated vesicles. seems to be required for axial budding pattern in haploid cells.
6485	binds to membranes enriched in phosphatidylinositol-4,5- biphosphate (ptdins(4,5)p2). modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (by similarity). regulates receptor-mediated endocytosis.
6486	
6487	muscle contraction.
6488	
6489	
6490	probable glycosyltransferase (by similarity).
6491	
6492	
6493	
6494	self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
6495	phosphorylates mkk3 (by similarity). activates the p38 map kinase pathway through the specific activation of the upstream mkk3 kinase.
6496	
6497	essential for recycling gmp and indirectly, cgmp.
6498	
6499	
6500	may play a role in intracellular transport of gaba(a) receptors and its interaction with the cytoskeleton (by similarity).
6501	chaperone that expresses an atpase activity.
6502	catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.
6503	transcription activator that binds dna cooperatively with dp proteins through the e2 recognition site, 5@#$%&-tttc[cg]cgc- 3@#$%& found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the drtf1/e2f complex functions in the control of cell-cycle progression from g1 to s phase. e2f-3 binds specifically to rb1 protein, in a cell-cycle dependent manner.
6504	
6505	collagen type iv is specific for basement membranes.
6506	
6507	integrin alpha-v/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von willebrand factor. integrin alpha-iib/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. integrins alpha-iib/beta-3 and alpha-v/beta-3 recognize the sequence r-g-d in a wide array of ligands. integrin alpha-iib/beta-3 recognizes the sequence h-h-l-g-g-g-a-k-q-a-g-d-v in fibrinogen gamma chain. following activation integrin alpha- iib/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. this step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
6508	may be involved in protein trafficking from the plasma membrane to the early endosome (ee) as well as in homotypic fusion of endocytic organelles. mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.
6509	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
6510	
6511	
6512	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
6513	
6514	
6515	may be involved in transcriptional regulation.
6516	muscle contraction.
6517	inhibitory regulator of the ras-cyclic amp pathway. binds inositol tetrakisphosphate (ip4) with high affinity. might be a specific ip4 receptor.
6518	
6519	
6520	
6521	
6522	
6523	adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. may link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
6524	involved in the second step of gpi biosynthesis. de-n- acetylation of n-acetylglucosaminyl-phosphatidylinositol.
6525	
6526	receptor for somatostatins-14 and -28. this receptor is coupled via pertussis toxin sensitive g proteins to inhibition of adenylyl cyclase. in addition it stimulates phosphotyrosine phosphatase and plc via pertussis toxin insensitive as well as sensitive g proteins. in rin-5f cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.
6527	involved in iron cellular uptake. seems to be internalized and then recycled back to the cell membrane. binds a single atom of iron per subunit. could also bind zinc.
6528	hydrolyzes adenosine 5@#$%&-monophosphoramidate substrates such as amp-morpholidate, amp-n-alanine methyl ester, amp-alpha- acetyl lysine methyl ester and amp-nh2 (by similarity).
6529	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
6530	
6531	may act as a lysosomal receptor.
6532	
6533	
6534	collagen type iv is specific for basement membranes.
6535	
6536	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. linked to the keratinization of epithelial tissues.
6537	
6538	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
6539	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
6540	
6541	
6542	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. n-cadherin may be involved in neuronal recognition mechanism.
6543	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
6544	involved in the presentation of foreign antigens to the immune system.
6545	specialized low-affinity urea transporter. mediates urea transport in erythrocytes.
6546	may play a fundamental role in early development of cns. may regulate gene expression and development of postmitotic undifferentiated young neurons.
6547	may function as a gtpase-activating protein.
6548	catalyzes the reduction of 3-ketodihydrosphingosine (kds) to dihydrosphingosine (dhs).
6549	
6550	
6551	
6552	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
6553	
6554	not known.
6555	
6556	could have a part in mechanisms of transcriptional regulation similar to that played by yeast hir1 and hir2 together.
6557	
6558	
6559	major high molecular weight protein of desmosomes. involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
6560	may be involved in transcriptional regulation.
6561	performs the first committed step in the biosynthesis of isoprenes.
6562	
6563	hydrolyzes an epoxide moiety of leukotriene a4 (lta-4) to form leukotriene b4 (ltb-4). the enzyme also has some peptidase activity.
6564	binds avidly to the au-rich element in fos and il3/interleukin-3 mrnas. in the case of the fos au-rich element, hur binds to a core element of 27 nucleotides that contain auuua, auuuua, and auuuuua motifs.
6565	in adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
6566	
6567	
6568	
6569	
6570	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (by similarity).
6571	
6572	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
6573	
6574	
6575	segment polarity protein, functions together with arm to transduce the wingless (wg) signal. acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
6576	couples tyrosine kinase signals with the activation of the rho/rac gtpases, thus leading to cell differentiation and/or proliferation.
6577	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
6578	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
6579	
6580	low affinity receptor which can bind to ngf, bdnf, nt-3, and nt-4. can mediate cell survival as well as cell death of neural cells.
6581	
6582	
6583	since they lack a putative transactivation domain, the small mafs behave as transcriptional repressors when they dimerize among themselves. however, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific dna-binding sites. small maf proteins heterodimerize with fos and may act as competitive repressors of the nf-e2 transcription factor. transcription factor, component of erythroid-specific transcription factor nf- e2. activates globin gene expression when associated with nf-e2.
6584	
6585	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
6586	
6587	
6588	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
6589	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
6590	
6591	acts late in the splicing of pre-mrna. mediates the release of the spliced mrna from spliceosomes.
6592	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
6593	
6594	may be involved in transcriptional regulation.
6595	
6596	may catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. specific for amino acid residues with aromatic side chains in the p1 position. scce cleaves insulin b chain at 6-leu-|-cys-7, 16-tyr-|-leu-17, 25- phe-|-tyr-26, and 26-tyr-|-thr-27. could play a role in the activation of precursors to inflammatory cytokines.
6597	may be a sfc-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear sr protein (non-snrnp splicing factors containing a serine/arginine-rich domain) trafficking and pre-mrna processing.
6598	
6599	sequence specific transcriptional activator which binds to the pu-box, a purine-rich dna sequence (5@#$%&-gaggaa-3@#$%&) that can act as a lymphoid-specific enhancer. promotes development of plasmacytoid dendritic cells (pdcs), also known as type 2 dc precursors (pre-dc2) or natural interferon (ifn)-producing cells. these cells have the capacity to produce large amounts of interferon and block viral replication. may be required for b-cell receptor (bcr) signaling, which is necessary for normal b-cell development and antigenic stimulation.
6600	
6601	
6602	
6603	
6604	
6605	
6606	
6607	possesses single-stranded dna-stimulated atpase and atp- dependent dna helicase (5@#$%& to 3@#$%&) activity. component of the nua4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. the nua4 complex atpase and helicase activities seem to be, at least in part, contributed by the association of ruvbl1 and ruvbl2 with ep400. nua4 may also play a direct role in dna repair when recruited to sites of dna damage. ruvbl2 plays an essential role in oncogenic transformation by myc and also modulates transcriptional activation by the lef1/tcf1 -ctnnb1 complex. may also inhibit the transcriptional activity of atf2.
6608	this protein seals, during dna replication, dna recombination and dna repair, nicks in double-stranded dna.
6609	
6610	
6611	
6612	inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin a. could play a role during central nervous system development (by similarity).
6613	
6614	promotes the exchange of ras-bound gdp by gtp.
6615	
6616	transcriptional activator which recognizes variations of the palindromic sequence 5@#$%&-attcccnngggaatt-3@#$%& (by similarity).
6617	
6618	may play a role in organizing the actin cytoskeleton of the brain cells.
6619	may be involved in transcriptional regulation.
6620	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
6621	
6622	
6623	the association of the dr1/drap1 heterodimer with tbp results in a functional repression of both activated and basal transcription of class ii genes. this interaction precludes the formation of a transcription-competent complex by inhibiting the association of tfiia and/or tfiib with tbp. can bind to dna on its own.
6624	
6625	
6626	
6627	
6628	may play a role in developmental myelination of peripheral nerves.
6629	
6630	
6631	
6632	
6633	probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. has been experimentally shown to be able to bind zinc.
6634	may play a role in macrophage activation and function.
6635	receptor for both mineralocorticoids (mc) such as aldosterone and glucocorticoids (gc) such as corticosterone or cortisol. binds to mineralocorticoid response elements (mre) and transactivates target genes. the effect of mc is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
6636	functions as a component of the nuclear pore complex (npc). npc components, collectively referred to as nucleoporins (nups), can play the role of both npc structural components and of docking or interaction partners for transiently associated nuclear transport factors. active directional transport is assured by both, a phe-gly (fg) repeat affinity gradient for these transport factors across the npc and a transport cofactor concentration gradient across the nuclear envelope (gsp1 and gsp2 gtpases associated predominantly with gtp in the nucleus, with gdp in the cytoplasm). nup116 plays an important role in several nuclear export and import pathways including poly(a)+ rna, trna, preribosome, and protein transport.
6637	
6638	may be implicated in endosomal trafficking, or microtubule dynamics, or both.
6639	
6640	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
6641	
6642	rna-binding protein that plays an essential role in spermatogenesis. may act by binding to the 3@#$%&utr of mrnas and regulating their translation.
6643	
6644	
6645	
6646	
6647	plays a role in hyaluronan/hyaluronic acid (ha) synthesis.
6648	
6649	may have a role in promoting cell migration (motogen).
6650	acts as a negative coregulator for lim homeodomain transcription factors. via the recruitment of the sin3a/histone deacetylase corepressor complex.
6651	
6652	
6653	
6654	may function in the secretion of milk-fat droplets. may act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (by similarity).
6655	
6656	may play a role in the regulation of plasmin-mediated matrix remodeling. inhibits trypsin, plasmin, factor viia/tissue factor and weakly factor xa. has no effect on thrombin.
6657	
6658	
6659	high affinity receptor for semaphorins 3c, 3f, vegf-165 and vegf-145 isoforms of vegf, and the plgf-2 isoform of pgf.
6660	
6661	
6662	it may catalyze the formation of the neuac-alpha-2,3- gal-beta-1,3-galnac- or neuac-alpha-2,3-gal-beta-1,3-glcnac- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. it may be involved in the biosynthesis of the sialyl lewis x determinant.
6663	
6664	targets myosin phosphatase to the actin cytoskeleton. required for the regulation of the actin cytoskeleton by rhoa and rock1. depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. overexpression of mrip as well as its f- actin-binding region leads to disassembly of stress fibers in neuronal cells.
6665	
6666	ubiquitous transcription factor required for a diverse set of processes. it is a component of the ccr4 complex involved in the control of gene expression (by similarity).
6667	
6668	
6669	
6670	
6671	
6672	collagen type iv is specific for basement membranes.
6673	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
6674	
6675	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.
6676	may be involved in pre-b-cell growth.
6677	insulin-regulated facilitative glucose transporter. binds cytochalasin b in a glucose-inhibitable manner. seems to be a dual-specific sugar transporter as it is inhibitable by fructose.
6678	histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a central role in histone code. preferentially demethylates mono- and dimethylated h3 lys-9 residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated h3 lys-9. demethylation of lys residue generates formaldehyde and succinate. involved in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes, resulting in h3 lys-9 demethylation and transcriptional activation.
6679	
6680	
6681	histone h4, along with histone h3, plays a central role in nucleosome formation.
6682	
6683	
6684	protease that regulate the availability of igfs by cleaving igf-binding proteins.
6685	motor for anterograde axonal transport of synaptic vesicle precursors (by similarity).
6686	
6687	may play an important role in cell growth and/or transcription.
6688	
6689	
6690	
6691	
6692	
6693	
6694	catalyzes the initial reaction in o-linked oligosaccharide biosynthesis, the transfer of an n-acetyl-d- galactosamine residue to a serine or threonine residue on the protein receptor. has a broad spectrum of substrates for peptides such as ea2, muc5ac, muc1a, muc1b and muc7.
6695	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
6696	
6697	nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. involved in the coactivation of different nuclear receptors, such as for steroids (pgr, gr and er), retinoids (rxrs), thyroid hormone (trs) and prostanoids (ppars). also involved in coactivation mediated by stat3, stat5a, stat5b and stat6 transcription factors. displays histone acetyltransferase activity toward h3 and h4; the relevance of such activity remains however unclear. plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. required with ncoa2 to control energy balance between white and brown adipose tissues. required for mediating steroid hormone response. isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
6698	interacts with htr2c and provokes its clustering at the cell surface (by similarity). member of the nmdar signaling complex that may play a role in control of ampar potentiation and synaptic plasticity in excitatory synapses.
6699	centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. may also act as a centrosome maturation factor. may play a role in microtubule nucleation. overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules.
6700	plasma membrane anion exchange protein of wide distribution. mediates at least a part of the cl(-)/hco3(-) exchange in cardiac myocytes. both bae3 and cae3 forms transport cl(-).
6701	may be involved in transcriptional regulation.
6702	
6703	
6704	
6705	may be involved in cell-adhesion. may function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (by similarity).
6706	seems to be involved in the cross-linking of microtubules and microfilaments.
6707	associates with the t-cell antigen receptor zeta chain (cd3z). plays a role in lymphocyte activation.
6708	
6709	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
6710	
6711	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction. interacts with beta-1 and beta-2, but not with beta-3.
6712	required for pre-mrna splicing. can also modulate alternative splicing in vitro.
6713	involved in axonal outgrowth and fasciculation (by similarity).
6714	may play a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. there are four molecules of fkbp12 per skeletal muscle ryr. ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
6715	
6716	may play a role in the apoptotic pathway or cell-cycle regulation induced by p53 after dna damage.
6717	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
6718	
6719	
6720	
6721	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. receptor for tgf-beta.
6722	may be involved in transcriptional regulation.
6723	catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine.
6724	
6725	
6726	regulator of egfr mediated signal transduction.
6727	
6728	binds to nfat-like motifs (purine-rich) in the hiv-1 long terminal repeat and in the il-2 promoter. may be involved in both positive and negative regulation of important viral and cellular promoter elements.
6729	serine protease that shows proteolytic activity against a nonspecific substrate beta-casein. promotes or induces cell death either by direct binding to and inhibition of birc proteins (also called inhibitor of apoptosis proteins, iaps), leading to an increase in caspase activity, or by a birc inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. isoform 2 seems to be proteolytically inactive.
6730	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. interacts specifically with wnt5a to induce the beta- catenin pathway.
6731	
6732	
6733	
6734	enzyme with a broad specificity. dephosphorylates cdk2 and cdk6 in vitro.
6735	the reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of dna to another.
6736	
6737	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. interacts with receptor-regulated smads specific for the bmp pathway, smad1 and smad5, in order to trigger their ubiquitination and degradation and hence their inactivation.
6738	microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. most probably involved in vesicular trafficking processes, in particular endocytosis.
6739	component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton.
6740	
6741	may participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or glut4 trafficking.
6742	
6743	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
6744	
6745	
6746	
6747	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
6748	
6749	required for genome wide de novo methylation and is essential for development. it modifies dna in a non-processive manner and also methylates non-cpg sites. acts as a transcriptional corepressor for znf238. can actively repress transcription through the recruitment of hdac activity.
6750	
6751	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis (by similarity).
6752	receptor for calcitonin-gene-related peptide (cgrp) together with ramp1 and receptor for adrenomedullin together with ramp2 or ramp3 (by similarity). the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
6753	
6754	complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. may form part of a tissue- specific acute response to remodeling stimuli. known to act on mmp-1, mmp-2, mmp-3, mmp-7, mmp-9, mmp-13, mmp-14 and mmp-15.
6755	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
6756	
6757	putative odorant receptor. could also be involved in taste perception.
6758	
6759	
6760	
6761	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
6762	may mediate accelerated atp-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
6763	
6764	actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
6765	
6766	may play a role in the er-associated degradation of misfolded glycoproteins.
6767	
6768	catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine.
6769	
6770	
6771	involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-coa to the tricarboxylic acid cycle. mcm has different functions in other species.
6772	
6773	
6774	
6775	
6776	
6777	
6778	
6779	this protein is a @#$%!fusion@#$%! protein encoding four enzymatic activities of the pyrimidine pathway (gatase, cpsase, atcase and dhoase).
6780	collagen type iv is specific for basement membranes.
6781	
6782	
6783	
6784	arm and abl proteins function cooperatively at adherens junctions in both the cns and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone@#$%&s response to midline cues. the ability of pcc/mp2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both slit/robo and abl-dependent signaling pathways.
6785	one of the essential components for the initiation of protein synthesis. protects formylmethionyl-trna from spontaneous hydrolysis and promotes its binding to the 30s ribosomal subunits. also involved in the hydrolysis of gtp during the formation of the 70s ribosomal complex.
6786	mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (nes) and of rnas. in the nucleus, in association with ranbp3, binds cooperatively to the nes on its target protein and to the gtpase ran in its active gtp-bound form. docking of this complex to the nuclear pore complex (npc) is mediated through binding to nucleoporins. upon transit of an nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of ran-gtp to ran-gdp (induced by ranbp1 and rangap1, respectively) cause release of the cargo from the export receptor. the directionality of nuclear export is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. also mediates the nuclear export of the rev protein of hiv-1 and rex protein of htlv-1. involved in rex dimerization. involved in u3 snorna transport from cajal bodies to nucleoli. binds to late precursor u3 snorna bearing a tmg cap. several virus, among them hiv-1, htlv-1 and influenza a may use it to export their rna genome out of the nucleus.
6787	
6788	required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
6789	
6790	
6791	probably required for kinetochore function, involved in chromosome segregation during mitosis. interacts with retinoblastoma protein (rb), cenp-e and bubr1.
6792	
6793	
6794	structural component of hyaline cartilage and vitreous of the eye.
6795	
6796	hydrolyzes both cyclic amp (camp) and cyclic gmp (cgmp).
6797	
6798	
6799	
6800	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
6801	
6802	catalyzes the formation of s-adenosylmethionine from methionine and atp.
6803	promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. inhibits formation of vascular-like structures. may be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
6804	collagen type ii is specific for cartilaginous tissues. it is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
6805	
6806	appears to function in the signal transduction from ras activation to actin cytoskeletal remodelling. suppresses insulin- induced promoter activities through ap1 and sre. mediates rap1- induced adhesion.
6807	
6808	may play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. could play a role in bone osteoclastic resorption. cleaves kiss1 at a gly-|-leu bond.
6809	
6810	
6811	binds to the metal-regulating-element (mre) of metallothionein-1a gene promoter. binding is zinc-dependent.
6812	
6813	atp-binding rna helicase involved in ribosome assembly.
6814	
6815	synthesis and degradation of fructose 2,6-bisphosphate.
6816	
6817	exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity.
6818	
6819	
6820	
6821	
6822	
6823	
6824	alters ptprf cellular localization and induces ptprf clustering. may regulate the disassembly of focal adhesions. may localize receptor-like tyrosine phosphatases type 2a at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
6825	presents carbohydrate ligands to selectins. also implicated in tumor cell metastasis.
6826	involved in pre-mrna splicing. this protein is associated with snrnp u2. it binds stem loop iv of u2 snrna only in presence of the u2a@#$%& protein.
6827	
6828	interacts specifically with a number of opioid ligands. receptor for neuropeptides b and w, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals.
6829	the 26s protease is involved in the atp-dependent degradation of ubiquitinated proteins. the regulatory (or atpase) complex confers atp dependency and substrate specificity to the 26s complex (by similarity).
6830	selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
6831	
6832	
6833	
6834	
6835	
6836	
6837	may be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. may play a role in cell migration.
6838	
6839	
6840	may act at junctions between the membrane and the cytoskeleton.
6841	can repress hiv-1 transcription by binding to the hiv-1 long terminal repeat. involved in the regulation of cftr splicing. it promotes cftr exon 9 skipping by binding to the ug repeated motifs in the polymorphic region near the 3@#$%& splice site of this exon. the resulting aberrant splicing is associated with pathological features typical of cystic fibrosis.
6842	
6843	
6844	may play a role in transcriptional regulation. in vitro, is associated with a kinase activity toward both rna polymerase ii c-terminal domain and cdk2 (cak).
6845	possible transcription factor. specifically binds to the ct/gc-rich region of the interleukin-3 promoter and mediates tax transactivation of il-3.
6846	essential component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. seems to control the nucleotide-dependent binding of mitochondrial hsp70 to substrate proteins.
6847	
6848	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. may play an important role in the destruction of aggrecan in arthritic diseases. may play a role in proteolytic processing mostly during the peri-implantation period.
6849	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation by repressing transcription of myocyte enhancer mef2c. during muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (by similarity).
6850	may constitute a glutathionine peroxidase-like protective system against oxidative stresses (by similarity).
6851	
6852	receptor for interleukin-7.
6853	
6854	facilitative glucose transporter (by similarity).
6855	
6856	
6857	
6858	major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
6859	
6860	protease which specifically processes pro-lysyl oxidase. required for the embryonic development. predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
6861	
6862	
6863	
6864	putative atp-dependent protease.
6865	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
6866	
6867	transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. potential role in g2/m cell cycle regulation (by similarity).
6868	
6869	
6870	
6871	induces the collapse and paralysis of neuronal growth cones. could potentially act as repulsive cues toward specific neuronal populations. binds to neuropilin (by similarity).
6872	
6873	type i collagen is a member of group i collagen (fibrillar forming collagen).
6874	
6875	
6876	plays a role in the formation of clathrin-coated invaginations and endocytosis.
6877	implicated in the suppression of cell death. interacts with the bcl-2 and adenovirus e1b 19 kda proteins (by similarity).
6878	may mediate translational control and perform an ef3- related function on the ribosome by regulating e2ak4 kinase activity.
6879	
6880	
6881	
6882	
6883	
6884	
6885	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
6886	phosphorylates rs domain-containing proteins, such as sfrs1 and sfrs2 on serine residues. role in spliceosome assembly and in mediating the trafficking of splicing factors. appears to mediate hbv core protein phosphorylation which is a prerequisite for pregenomic rna encapsidation into viral capsids.
6887	involved in the transport of proteins between the endosomes and the trans golgi network (by similarity).
6888	has a high affinity for both camp and cgmp.
6889	immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. participates also in the recruitment of tyrosine kinase syk.
6890	
6891	
6892	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling. phosphorylates dvl1.
6893	
6894	
6895	
6896	
6897	functions as histone acetyltransferase and regulates transcription via chromatin remodeling. acetylates all four core histones in nucleosomes. histone acetylation gives an epigenetic tag for transcriptional activation. binds to and may be involved in the transforming capacity of the adenovirus e1a protein. mediates camp-gene regulation by binding specifically to phosphorylated creb protein.
6898	
6899	participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
6900	
6901	
6902	the isoform smdf may play a role in motor and sensory neuron development.
6903	receptor for the cx3c chemokine fractalkine and mediates both its adhesive and migratory functions. acts as coreceptor with cd4 for hiv-1 virus envelope protein (in vitro). isoform 2 and isoform 3 seem to be more potent hiv coreceptors than isoform 1.
6904	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
6905	promotes caspase-mediated apoptosis. this proapoptotic activity is mediated predominantly through the activation of caspase 9. may be a component of the inflammasome, a protein complex which also includes nalp2, card8 and casp1 and whose function would be the activation of proinflammatory caspases (by similarity).
6906	histone acetyltransferase which may act as a transcriptional coactivator for runx1 and runx2.
6907	
6908	
6909	may be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. may also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
6910	transcriptional repressor. mad binds with max to form a sequence-specific dna-binding protein complex which recognizes the core sequence 5@#$%&-cac[ga]tg-3@#$%&. mad thus antagonizes myc transcriptional activity by competing for max.
6911	
6912	transcription termination factor. binds to a 28 bp region within the trna(leu(uur)) gene at a position immediately adjacent to and downstream of the 16s rrna gene, this region comprises a tridecamer sequence critical for directing accurate termination. probably requires one or more components for termination activity.
6913	
6914	involved in early stages of melanosome biogenesis and maturation (by similarity).
6915	molecular chaperone; assists the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin (by similarity).
6916	involved in early stages of melanosome biogenesis and maturation (by similarity).
6917	
6918	may play a role in germ line formation.
6919	
6920	involved in the presentation of foreign antigens to the immune system.
6921	
6922	
6923	catalyzes the transfer of sulfate to position 6 of non- reducing n-acetylglucosamine (glcnac) residues within keratan-like structures on n-linked glycans and within mucin-associated glycans that can ultimately serve as l-selectin ligands. l-selectin ligands are present in high endothelial cells (hevs) and play a central role in lymphocyte homing at sites of inflammation. participates in biosynthesis of l-selectin ligand sialyl 6-sulfo lewis x and in lymphocyte homing to peyer patches. has no activity toward o-linked sugars. its substrate specificity may be influenced by its subcellular location. sulfates glcnac residues at terminal, nonreducing ends of oligosaccharide chains.
6924	may be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.
6925	induces apoptosis. interacts with viral and cellular anti-apoptosis proteins. can overcome the suppressors bcl-2 and bcl-xl, although high levels of bcl-xl expression will inhibit apoptosis. may function as a tumor suppressor.
6926	collagen type iii occurs in most soft connective tissues along with type i collagen.
6927	appears to be involved in myelination. could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and k(+)-selective (by similarity).
6928	
6929	
6930	
6931	transcription activator that binds dna cooperatively with dp proteins through the e2 recognition site, 5@#$%&-tttc[cg]cgc- 3@#$%& found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the drtf1/e2f complex functions in the control of cell-cycle progression from g1 to s phase. e2f-2 binds specifically to rb1 protein, in a cell-cycle dependent manner.
6932	calcium-dependent mitochondrial solute carrier (by similarity).
6933	
6934	
6935	involved in the transport of glutamate across the inner mitochondrial membrane. glutamate is cotransported with h(+).
6936	
6937	involved in the transduction of mitogenic signals from the cell membrane to the nucleus. part of the ras-dependent signaling pathway from receptors to the nucleus.
6938	enzyme with a broad specificity.
6939	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
6940	capable of removing ubiquitin from ubiquitinated proteins; also capable of removing nedd8 from nedd8 conjugates but has no effect on sentrin-1 conjugates.
6941	
6942	binds to, and destabilizes, ornithine decarboxylase which is then degraded. also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter.
6943	binds to, and destabilizes, ornithine decarboxylase which is then degraded. also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter.
6944	
6945	
6946	
6947	
6948	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
6949	
6950	
6951	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
6952	receptor for atp that acts as a ligand gated ion channel. responsible for atp-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. could function in both fast synaptic transmission and the atp-mediated lysis of antigen-presenting cells.
6953	
6954	
6955	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
6956	
6957	
6958	
6959	
6960	this is an intracellular thiol proteinase inhibitor.
6961	circadian regulator that may act as a transcription factor. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition. expression oscillates with a 24 hour rhythm in the suprachiasmatic nucleus (scn) and the whole eyes. oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. there is a 4 hour time delay between per1 and per2 oscillations. the expression rhythms appear to originate from retina (by similarity).
6962	
6963	functions as a histone acetyltransferase (hat) to promote transcriptional activation. has significant histone acetyltransferase activity with core histones (h3 and h4), and also with nucleosome core particles. inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein e1a.
6964	important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. specifically binds to an il-1 response element in the il-6 gene. nf-il6 also binds to regulatory regions of several acute-phase and cytokines genes. it probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. the consensus recognition site is 5@#$%&-t[tg]nngnaa[tg]-3@#$%&.
6965	
6966	
6967	
6968	
6969	
6970	
6971	
6972	
6973	
6974	
6975	collagen type iii occurs in most soft connective tissues along with type i collagen.
6976	muscle contraction.
6977	may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes (by similarity).
6978	
6979	cell adhesion molecule that binds to cd6. involved in neurite extension by neurons via heterophilic and homophilic interactions. may play a role in the binding of t- and b-cells to activated leukocytes, as well as in interactions between cells of the nervous system.
6980	receptor for a c-c type chemokine. binds to mip-1-alpha, mip-1-beta and rantes and subsequently transduces a signal by increasing the intracellular calcium ions level. may play a role in the control of granulocytic lineage proliferation or differentiation. acts as a coreceptor (cd4 being the primary receptor) for hiv-1 r5 isolates.
6981	stimulates hepatic and intestinal proliferation.
6982	
6983	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
6984	associated with the mammalian reproductive process. catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
6985	may serve as dna-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
6986	
6987	probable scaffold protein that may be involved in mrna transport (potential).
6988	
6989	involved in controlling the equilibrium between tubular and stacked structures in the golgi complex (by similarity). co- repressor targeting diverse transcription regulators. has dehydrogenase activity.
6990	
6991	
6992	
6993	
6994	
6995	
6996	
6997	may be a mediator of localized cell proliferation. as a mitogen it may stimulate cell proliferation and/or angiogenesis.
6998	
6999	
7000	
7001	
7002	
7003	antagonizes the binding of 2-5a (5@#$%&-phosphorylated 2@#$%&,5@#$%&-linked oligoadenylates) by rnase l through direct interaction with rnase l and therefore inhibits its endoribonuclease activity. may play a central role in the regulation of mrna turnover. antagonizes the anti-viral effect of the interferon-regulated 2-5a/rnase l pathway. may act as a chaperone for post-translational events during hiv-1 capsid assembly.
7004	
7005	
7006	
7007	may be required for testis development.
7008	
7009	may be involved in several stages of intracellular trafficking (by similarity).
7010	
7011	
7012	type i collagen is a member of group i collagen (fibrillar forming collagen).
7013	
7014	
7015	bifunctional enzyme that catalyzes the fourth and fifth sequential steps of coa biosynthetic pathway. the fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coad domain; the fifth reaction is catalyzed by the dephospho-coa kinase, coded by the coae domain. may act as a point of coa biosynthesis regulation.
7016	
7017	
7018	
7019	
7020	
7021	ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. it has ferroxidase activity oxidizing iron(ii) to iron(iii) without releasing radical oxygen species. it is involved in iron transport across the cell membrane.
7022	stimulates specifically the gtpase activity of ypt6.
7023	
7024	collagen type iii occurs in most soft connective tissues along with type i collagen.
7025	
7026	
7027	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
7028	
7029	
7030	transcription factor that binds to gc box promoter elements. selectively activates mrna synthesis from genes containing tandem repeats of gc boxes but represses genes with a single gc box.
7031	
7032	regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. the condensin complex probably introduces positive supercoils into relaxed dna in the presence of type i topoisomerases and converts nicked dna into positive knotted forms in the presence of type ii topoisomerases.
7033	anchoring filament protein which is a component of the basement membrane zone. may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. could maintain dermal-epidermal cohesion.
7034	
7035	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
7036	
7037	
7038	
7039	may play an accessory role in the regulation of protein biosynthesis.
7040	may function as a phosphatase involved in the regulation of cell growth and differentiation.
7041	
7042	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
7043	
7044	essential for cell viability. taf9 and taf9b are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. may have a role in gene regulation associated with apoptosis. tafs are components of the transcription factor iid (tfiid) complex, the tbp-free tafii complex (tftc), the pcaf histone acetylase complex and the staga transcription coactivator-hat complex. tfiid or tftc are essential for the regulation of rna polymerase ii-mediated transcription.
7045	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
7046	
7047	
7048	
7049	tumor suppressor that may be involved in interferon- dependent cell death (by similarity).
7050	
7051	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
7052	
7053	
7054	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
7055	implicated in tumor cell metastasis. may function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction.
7056	
7057	
7058	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
7059	
7060	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
7061	probable chloride channel (by similarity).
7062	
7063	
7064	
7065	may be involved in neuronal differentiation.
7066	may be involved in neuronal differentiation.
7067	seems to bind protein kinase c acting as an intracellular receptor to anchor the activated pkc to the cytoskeleton (by similarity).
7068	
7069	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb.
7070	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
7071	
7072	
7073	
7074	
7075	required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors. may bind a rab gtpase such as vps21.
7076	stimulates gtp hydrolysis of members of the rho family. could activates gtpase targets that are known to affect cell migration and outgrowth of axons and dendrites.
7077	
7078	
7079	
7080	component of a protein kinase signal transduction cascade. activates the erk and jnk kinase pathways by phosphorylation of map2k1 and map2k4. activates chuk and ikbkb, the central protein kinases of the nf-kappa-b pathway.
7081	
7082	may be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. may play a role in cell migration (by similarity).
7083	class-iv neuronal intermediate filament that is able to self-assemble. it is involved in the morphogenesis of neurons. it may form an independent structural network without the involvement of other neurofilaments or it may cooperate with nf-l to form the filamentous backbone to which nf-m and nf-h attach to form the cross-bridges (by similarity).
7084	
7085	
7086	probable protein phosphatase (by similarity).
7087	promotes cell survival. blocks dexamethasone-induced apoptosis. mediates survival of postmitotic sertoli cells by suppressing death-promoting activity of bax.
7088	regulates downstream kinases in response to environmental stress. may also have a function in regulating the actin cytoskeleton.
7089	
7090	
7091	non-essential protein involved in fatty acid metabolism.
7092	
7093	transcription factor that binds specifically to the distal ras-responsive element (rre) in the calcitonin gene promoter and augment the ras/raf-mediated transcriptional response of that promoter. may be involved in ras/raf-mediated cell differentiation.
7094	
7095	highly specific for ethanolamine phosphorylation. may be a rate-controlling step in phosphatidylathanolamine biosynthesis (by similarity).
7096	binds to gtp-bound form of rho and to profilin. acts in a rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. it is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics (by similarity).
7097	may direct with other members of the subcomplex rna pol iii binding to the tfiiib-dna complex via the interactions between tfiiib and polr3f. may be involved either in the recruitment and stabilization of the subcomplex within rna polymerase iii, or in stimulating catalytic functions of other subunits during initiation.
7098	
7099	
7100	orphan receptor.
7101	promotes angiogenesis and the proliferation of endothelial cells. able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
7102	
7103	
7104	
7105	
7106	
7107	forms critical branches in o-glycans.
7108	could function as a cell-adhesion protein. acts as a tumor suppressor. required for correct morphogenesis.
7109	
7110	
7111	this is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters. may be considered as a novel component of the nf-kappa-b signaling axis responsible for the survival and activation of b-cells after bcr cross-linking (by similarity).
7112	
7113	
7114	
7115	
7116	
7117	
7118	putative rho/rac effector that binds to the gtp-bound forms of rho and rac1. it probably binds p21 with a tighter specificity in vivo. dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. plays an important role in the regulation of cytokinesis and the development of the central nervous system (by similarity).
7119	may play a role in promoting maturation and morphological differentiation of cerebellar neurons.
7120	may activate nf-kappa-b and jnk and promote apoptosis.
7121	may regulate the disassembly of focal adhesions. may localize receptor-like tyrosine phosphatases type 2a at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (by similarity).
7122	
7123	
7124	possible receptor for triiodothyronine.
7125	
7126	
7127	required for transport of secretory proteins from the golgi complex. catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. essential for viability and secretion.
7128	
7129	
7130	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
7131	
7132	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis. regulates the ca(2+)- dependent secretion of norepinephrine in pc12 cells. required for export from the endocytic recycling compartment to the cell surface (by similarity).
7133	
7134	receptor that binds specifically to pdgfb and has a tyrosine-protein kinase activity. phosphorylates tyr residues at the c-terminus of ptpn11 creating a binding site for the sh2 domain of grb2.
7135	may play a role as a mediator of inflammation and angiogenesis.
7136	involved in peroxisome biosynthesis. required for stability of the pts1 receptor. anchored by pex26 to peroxisome membranes, possibly to form heteromeric aaa atpase complexes required for the import of proteins into peroxisomes.
7137	
7138	
7139	
7140	
7141	
7142	
7143	binds to g-rich structures in 28s rrna and in mrnas. plays a regulatory role in the translation apparatus; inhibits cell-free translation of mrnas.
7144	may have a regulatory bifunctional role.
7145	inhibits the transactivation activity of the myod family of myogenic factors and represses myogenesis. acts by associating with myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. can also interfere with the dna-binding activity of myod family members. plays an important role in trophoblast and chondrogenic differentiation (by similarity).
7146	
7147	
7148	important for the resorption of phosphate by the kidney. may be involved in actively transporting phosphate into cells via na(+) cotransport in the renal brush border membrane.
7149	histone h3, along with histone h4, plays a central role in nucleosome formation.
7150	
7151	involved in gm1/gd1b/ga1 ganglioside biosynthesis.
7152	
7153	type i collagen is a member of group i collagen (fibrillar forming collagen).
7154	probably involved in ubiquitination and subsequent proteasomal degradation of target proteins. plays a role in the polyubiquitination of cdt1 in response to radiation-induced dna damage.
7155	histone methyltransferase. methylates lys-9 of histone h3 and weakly histone h1 (in vitro). h3 lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting hp1 proteins to methylated histones. targeted to histone h3 by rb1. seems to participate in regulation of higher order chromatin organization at mammalian centromeres.
7156	
7157	
7158	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
7159	
7160	
7161	
7162	
7163	probably involved in lipid transport.
7164	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
7165	the intermediate chains seem to help dynein bind to dynactin 150 kda component. may play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
7166	
7167	derived from proteolytic degradation of complement c4, c4a anaphylatoxin is a mediator of local inflammatory process. it induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
7168	
7169	acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. one of the activated genes is an inhibitor of cyclin-dependent kinases. apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of bcl-2 expression.
7170	
7171	
7172	plays a critical role in catalyzing the release of class ii hla-associated invariant chain-derived peptides (clip) from newly synthesized class ii hla molecules and freeing the peptide binding site for acquisition of antigenic peptides.
7173	nuclear hormone receptor. involved in the retinoic acid response pathway. binds 9-cis retinoic acid (9c-ra). arf6 acts as a key regulator of the tissue-specific adipocyte p2 (ap2) enhancer (by similarity).
7174	may play an important role in fibrillogenesis by controlling lateral growth of collagen ii fibrils.
7175	component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix.
7176	
7177	
7178	diverse functions during morphogenesis in drosophila. complete loss-of-function mutations lead to late embryonic lethality. certain partial loss-of-function mutations give raise to escaper adults, which have rough eyes associated with changes in cell fate and pattern, misshappen legs and defects in wing structure.
7179	
7180	
7181	transcription factors activated upon intramembrane proteolysis (rip), binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ag][ag]-3@#$%&), a sequence present in many viral and cellular promoters. binds to and requires hcfc1 as a coactivator. activity and expression are suppressed when the hcfc1-creb3 complex binds with zf. participates in lkn-1/ccl15- induced chemotaxis signaling.
7182	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
7183	
7184	required for protein transport from the er to the golgi complex.
7185	transcriptional repressor; binds to the dna sequence 5@#$%&- ccggaagt-3@#$%&. isoform a and isoform c do not seem to have a repressor activity.
7186	
7187	
7188	transcriptional repressor. binds with max to form a sequence-specific dna-binding protein complex which recognizes the core sequence cac[ga]tg. antagonizes myc transcriptional activity by competing for max (by similarity).
7189	acts as an a-kinase anchoring protein by binding to the type ii regulatory subunit of protein kinase a and anchoring it to the mitochondrion. also involved in synchronization of mitochondrial fission.
7190	
7191	
7192	
7193	
7194	may play a role in cytoskeletal stability (by similarity).
7195	transcription factor that binds to the octamer motif (5@#$%&-atttgcat-3@#$%&) and activates the promoters of the genes for some small nuclear rnas (snrna) and of genes such as those for histone h2b and immunoglobulins. modulates transcription transactivation by nr3c1, ar and pgr (by similarity).
7196	mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.
7197	
7198	it is involved in repression by a1-alpha2 and alpha2 and in other systems as a general repressor of transcription. this protein has no obvious dna-binding domains. it might not interact directly with dna but with dna-bound proteins.
7199	
7200	
7201	
7202	
7203	
7204	
7205	
7206	may be involved in several stages of intracellular trafficking.
7207	
7208	plays a role in a process governing chromosomal dynamics during mitosis (by similarity).
7209	
7210	
7211	
7212	
7213	probably required for protein import into peroxisomes. anchors pex1 and pex6 to peroxisome membranes, possibly to form heteromeric aaa atpase complexes required for the import of proteins into peroxisomes. involved in the import of catalase and proteins containing a pts22 target sequence, but not in import of proteins with a pts1 target sequence.
7214	
7215	
7216	
7217	
7218	essential for embryogenesis, including development of the placenta, heart and liver (by similarity). plays a role in transcriptional coactivation.
7219	
7220	has antibacterial activity.
7221	
7222	
7223	v-snare that mediates vesicle transport pathways through interactions with t-snares on the target membrane. these interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. may participate in protein trafficking in the secretory pathway.
7224	
7225	
7226	may play a role in notch signaling (by similarity).
7227	
7228	
7229	cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an l-selectin- independent fashion. has a monoamine oxidase activity.
7230	
7231	may be involved in transcriptional regulation.
7232	
7233	may be required for neuronal cell differentiation.
7234	subunit of the 26s proteasome which plays a role in ubiquitin-dependent proteolysis.
7235	
7236	may play a role in the regulation of rhoa gtpase by guanine nucleotide-binding alpha-12 (gna12) and alpha-13 (gna13). acts as guanine nucleotide exchange factor (gef) for rhoa gtpase and may act as gtpase-activating protein (gap) for gna12 and gna13.
7237	
7238	plays a major role in tight junction-specific obliteration of the intercellular space (by similarity).
7239	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
7240	
7241	
7242	activates erythroid-specific, globin gene expression.
7243	probable histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a central role in histone code. demethylation of lys residue generates formaldehyde and succinate. may be involved in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes (by similarity).
7244	
7245	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
7246	cytokine that contributes to the inflammatory response in vivo.
7247	
7248	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
7249	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
7250	may catalyze alpha-1,3 glycosidic linkages involved in the expression of lewis x/ssea-1 and vim-2 antigens.
7251	
7252	
7253	
7254	
7255	potent tight-binding inhibitor of several g1 cyclin/cdk complexes (cyclin e-cdk2, cyclin d2-cdk4, and cyclin a-cdk2) and, to lesser extent, of the mitotic cyclin b-cdc2. negative regulator of cell proliferation. may play a role in maintenance of the nonproliferative state throughout life.
7256	
7257	may be involved in the regulation of gene transcription and chromatin structure.
7258	
7259	
7260	
7261	most effectively accelerate the intrinsic gtpase activity of ypt7. it is also active, but to a lesser extent, on ypt31, ypt32 and ypt1. ypt6 and sec4.
7262	
7263	
7264	may be involved in transcriptional regulation.
7265	
7266	
7267	
7268	
7269	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
7270	this rnase has marked specificity towards the 3@#$%& side of uridine nucleotides.
7271	
7272	
7273	
7274	
7275	
7276	required for the import and folding of small cysteine- containing proteins (small tim) in the mitochondrial intermembrane space (ims). probably acts by forming a redox cycle with gfer/erv1 that involves a disulfide relay system. precursor proteins to be imported into the ims are translocated in their reduced form into the mitochondria. the oxidized form of mia40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the ims (probable).
7277	
7278	
7279	
7280	
7281	
7282	binds specifically and cooperatively to the sph and gt- iic @#$%!enhansons@#$%! (5@#$%&-gtggaatgt-3@#$%&) and activates transcription in vivo in a cell-specific manner. the activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (tif). involved in cardiac development. binds to the m-cat motif.
7283	may be involved in transcriptional regulation.
7284	
7285	
7286	inter-alpha-trypsin inhibitor, present in plasma and urine, inhibits trypsin, plasmin, and lysosomal granulocytic elastase (by similarity).
7287	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
7288	
7289	
7290	required for protein transport from the er to the golgi complex.
7291	may play a role in physiologic lymphocyte functions at mucosal sites.
7292	type ii regulatory chains mediate membrane association by binding to anchoring proteins, including the map2 kinase.
7293	may be an adhesion-like molecule with anti-protease activity.
7294	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
7295	probably important in cardiac repolarization. associates with kcne1 (mink) to form the i(ks) cardiac potassium current. elicits a rapidly activating, potassium-selective outward current. muscarinic agonist oxotremorine-m strongly suppresses kcnq1/kcne1 current in cho cells in which cloned kcnq1/kcne1 channels were coexpressed with m1 muscarinic receptors. may associate also with kcne3 (mirp2) to form the potassium channel that is important for cyclic amp-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
7296	fosb interacts with jun proteins enhancing their dna binding activity.
7297	may be involved in cell migration and/or actin cytoskeleton organization. when expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. required for normal lung cell proliferation and alveolus formation at birth. induces platelet aggregation. does not have any effect on folic acid or amino acid transport. does not function as a water channel or as a regulator of aquaporin-type water channels (by similarity).
7298	
7299	
7300	
7301	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
7302	
7303	
7304	
7305	
7306	
7307	
7308	
7309	component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level.
7310	
7311	
7312	retains nfe2l2/nrf2 in the cytosol thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.
7313	
7314	this protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate (by similarity).
7315	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
7316	
7317	may be involved in transcriptional regulation.
7318	
7319	type i collagen is a member of group i collagen (fibrillar forming collagen).
7320	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna.
7321	
7322	necessary for the splicing of pre-mrna. binds to the polypyrimidine tract of introns early during spliceosome assembly. required for the export of mrna out of the nucleus, even if the mrna is encoded by an intron-less gene.
7323	splice factor that is required for the first atp- dependent step in spliceosome assembly and for the interaction of u2 snrnp with the branchpoint. has weak rna-dependent atpase activity. required for mrna export.
7324	
7325	
7326	strong transcriptional activator; dna-binding protein that specifically recognize the sequence 5@#$%&-yaac[gt]g-3@#$%&. could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and b-lymphoid cells.
7327	
7328	
7329	
7330	
7331	involved in cytokinesis (potential). can bind to gtp and exert gtpase activity.
7332	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
7333	
7334	
7335	calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. phosphorylates camk1, camk1d, camk1g and camk4. involved in regulating cell apoptosis. promotes cell survival by phosphorylating akt1/pkb that inhibits pro-apoptotic bad/bcl2-antagonist of cell death.
7336	
7337	
7338	
7339	
7340	involved in the synthesis of the gdp-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (by similarity).
7341	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
7342	
7343	
7344	not known.
7345	
7346	
7347	glycosyltransferase required for the biosynthesis of heparan-sulfate. the ext1/ext2 complex possesses substantially higher glycosyltransferase activity than ext1 or ext2 alone. appears to be a tumor suppressor.
7348	
7349	
7350	cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a bmp antagonist required for early limb outgrowth and patterning in maintaining the fgf4-shh feedback loop. down-regulates the bmp4 signaling in a dose-dependent manner. acts as inhibitor of monocyte chemotaxis (by similarity).
7351	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
7352	may play a role in the proliferation or differentiation of keratinocytes.
7353	
7354	implicated in the suppression of cell death. interacts with the bcl-2 and adenovirus e1b 19 kda proteins (by similarity).
7355	may play a role in antiviral host defense. protects against infection by a neurovirulent strain of sindbis virus. may play a role in autophagy.
7356	
7357	
7358	
7359	
7360	
7361	its interaction with phyh suggests a role in the development of the central system.
7362	
7363	extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development (by similarity).
7364	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
7365	
7366	
7367	may be involved in transcriptional regulation.
7368	
7369	receptor for atp that acts as a ligand gated ion channel.
7370	affects the rate of fibrils formation. may have a primary role in collagen fibrillogenesis (by similarity).
7371	
7372	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. activity on g(z)-alpha is inhibited by phosphorylation of the g-protein. activity on g(z)-alpha and g(i)-alpha-1 is inhibited by palmitoylation of the g-protein.
7373	component c2 which is part of the classical pathway of the complement system is cleaved by activated factor c1 into two fragments: c2b and c2a. c2a, a serine protease, then combines with complement factor 4b to generate the c3 or c5 convertase.
7374	
7375	
7376	
7377	
7378	
7379	
7380	
7381	prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
7382	specific inhibition of calpain (calcium-dependent cysteine protease). plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
7383	promotes motor nerve regeneration (by similarity). may be involved in intracellular vesicle traffic.
7384	
7385	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
7386	
7387	
7388	binds vldl and transports it into cells by endocytosis. in order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. binding to reelin induces tyrosine phosphorylation of dab1 and modulation of tau phosphorylation (by similarity).
7389	
7390	expressed by macrophages in chronic inflammations. also expressed in epithelial cells constitutively or induced during dermatoses. may interact with components of the intermediate filaments in monocytes and epithelial cells.
7391	acts as a negative regulator of the proliferation of normal cells by interacting strongly with cdk4 and cdk6. this inhibits their ability to interact with cyclins d and to phosphorylate the retinoblastoma protein.
7392	
7393	
7394	
7395	may facilitate double-stranded rna-regulated gene expression at the level of post-transcription. can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (gcase) and other mrnas and functions at the initiation phase of gcase mrna translation, probably by inhibiting its binding to polysomes. can regulate protein arginine n- methyltransferase 1 activity. may regulate transcription of the il2 gene during t-cell activation. can promote the formation of stable dna-dependent protein kinase holoenzyme complexes on dna.
7396	
7397	may act as a charged protein scaffold to promote snrnp assembly or strengthen snrnp-snrnp interactions through nonspecific electrostatic contacts with rna.
7398	
7399	
7400	
7401	
7402	
7403	
7404	
7405	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
7406	
7407	necessary for centrosome duplication.
7408	
7409	
7410	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
7411	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
7412	senses unfolded proteins in the lumen of the endoplasmic reticulum via its n-terminal domain which leads to enzyme auto- activation. the active endoribonuclease domain splices xbp1 mrna to generate a new c-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
7413	
7414	belongs to an adhesion system, probably together with the e-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (ajs). nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
7415	
7416	
7417	mediates rac1-dependent reorganization of actin filaments (by similarity). participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
7418	may be involved in transcriptional regulation.
7419	likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. may play a role in the differentiation of spermatozoa and oocytes.
7420	involved in poly(a)+ rna transport.
7421	
7422	
7423	
7424	required for maturation of the 25s and 5.8s ribosomal rnas. required for proper processing at four distinct sites located within the internal transcribed spacers its1 and its2 and the 3@#$%& external spacer. may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rrna (by similarity).
7425	may be involved in the assembly, secretion and targeting of tgfb1 to sites at which it is stored and/or activated. may play critical roles in controlling and directing the activity of tgfb1. may have a structural role in the extra cellular matrix (ecm).
7426	ileal protein which stimulates gastric acid and pepsinogen secretion. seems to be able to bind to bile salts and bilirubins.
7427	
7428	
7429	
7430	
7431	
7432	
7433	involved in pyrimidine base degradation. catalyzes the reduction of uracil and thymine. also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
7434	
7435	
7436	required for tcr (t-cell antigen receptor)- and pre-tcr- mediated signaling, both in mature t-cells and during their development. involved in fcgr3 (low affinity immunoglobulin gamma fc region receptor iii)-mediated signaling in natural killer cells and fcer1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, pkc activation, mapk activation or cytoskeletal reorganization through the recruitment of plcg1, grb2, grap2, and other signaling molecules.
7437	required for tcr (t-cell antigen receptor)- and pre-tcr- mediated signaling, both in mature t-cells and during their development. involved in fcgr3 (low affinity immunoglobulin gamma fc region receptor iii)-mediated signaling in natural killer cells and fcer1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, pkc activation, mapk activation or cytoskeletal reorganization through the recruitment of plcg1, grb2, grap2, and other signaling molecules.
7438	dna primase is the polymerase that synthesizes small rna primers for the okazaki fragments made during discontinuous dna replication.
7439	
7440	
7441	
7442	
7443	
7444	may play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (nr) and acts in cooperation with ncoa2 and carm1. involved in estrogen hormone signaling. involved in early embryonic development (by similarity). may play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration.
7445	
7446	may function in combinations with otx1/2 to specify cell fates in the developing central nervous system.
7447	
7448	
7449	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna (by similarity).
7450	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
7451	
7452	muscle contraction.
7453	transcriptional factor. activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta- globin gene and represses promoters containing sp1-like binding sites inhibiting cell growth.
7454	nuclease that induces dna fragmentation and chromatin condensation during apoptosis. degrades naked dna and induces apoptotic morphology.
7455	this is the heme a-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
7456	the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the er, via the golgi up to the trans golgi network. coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-er transport of dilysine-tagged proteins. in mammals, the coatomer can only be recruited by membranes associated to adp-ribosylation factors (arfs), which are small gtp-binding proteins; the complex also influences the golgi structural integrity, as well as the processing, activity, and endocytic recycling of ldl receptors (by similarity).
7457	
7458	
7459	seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.
7460	binds highly specifically to rhoa, rhoc and rac proteins, but does not appear to catalyze guanine nucleotide exchange (by similarity).
7461	drastically down-regulated in response to pdgf-bb or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. seems to play a role in the development of the embryonic vascular system.
7462	
7463	involved in exocytosis by regulating a late step in synaptic vesicle fusion. could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (by similarity).
7464	
7465	
7466	
7467	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
7468	can be a regulatory factor required for the differentiation and/or phenotypic maintenance of neurons.
7469	
7470	
7471	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
7472	
7473	involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. functions as a guanine nucleotide exchange factor (gef), which activates rac rho small gtpases by exchanging bound gdp for free gtp. its gef activity may be enhanced by elmo1.
7474	
7475	
7476	
7477	
7478	growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. binds and activates vegfr-2 (flk1) and vegfr-3 (flt4) receptors.
7479	this tyrosine kinase receptor for fibrillar collagen mediates fibroblast migration and proliferation. contributes to cutaneous wound healing (by similarity).
7480	
7481	may be involved in transcriptional regulation.
7482	inhibitor of the slam self-association. acts by blocking recruitment of the sh2-domain-containing signal-transduction molecule shp-2 to a docking site in the slam cytoplasmic region.
7483	the function of the small subunit is not yet clear.
7484	
7485	
7486	critical growth regulator in the pathogenesis of meningiomas.
7487	important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
7488	
7489	binds intracellular amyloid-beta. by interacting with amyloid-beta, it may contribute to the neuronal dysfunction associated with alzheimer disease (ad).
7490	
7491	possible chloride ion channel.
7492	
7493	regulates the gdp/gtp exchange reaction of most rab proteins by inhibiting the dissociation of gdp from them, and the subsequent binding of gtp to them.
7494	
7495	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. interacts with amino-terminal region (aa 2 to 181) of cdc6.
7496	may be a signaling adapter molecule involved in p75ntr- mediated apoptosis induced by ngf. plays a role in zinc-triggered neuronal death (by similarity). may play an important role in the pathogenesis of neurogenetic diseases.
7497	guanine nucleotide exchange factor (gef) that modulates the rho family of gtpases. promotes the conversion of some member of the rho family gtpase from the gdp-bound to the gtp-bound form. isoform 1 exhibits no activity toward rhoa, rac1 or cdc42. isoform 2 exhibits decreased gef activity toward cdc42. isoform 3 exhibits a weak but significant activity toward rac1 and cdc42. isoform 4 exhibits significant activity toward rhoa and cdc42. the truncated dbl oncogene is active toward rhoa, rac1 and cdc42.
7498	not known; binds heterotrimeric g proteins.
7499	
7500	
7501	plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity.
7502	component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnrnp). hnrnp play an important role in processing of precursor mrna in the nucleus.
7503	splicing factor that in its dephosphorylated form acts as a general repressor of pre-mrna splicing. seems to interfere with the u1 snrnp 5@#$%&-splice recognition of snrp70. required for splicing repression in m-phase cells and after heat shock. may be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
7504	
7505	
7506	catalytic component of isw1-type complexes, which act by remodelling the chromatin by catalyzing an atp-dependent alteration in the structure of nucleosomal dna. they are involved in coordinating transcriptional repression, activation and elongation phases. the isw1a complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome. the isw1b complex acts within coding regions to control the amount of rna polymerase ii released into productive elongation and to coordinate elongation with termination and pre- mrna processing.
7507	resistance to tetracycline by an active tetracycline efflux. this is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. this protein functions as a metal-tetracycline/h(+) antiporter.
7508	
7509	component of the cytoplasmic fibrils of the nuclear pore complex implicated in nuclear protein import. its n-terminus is involved in activation of oncogenic kinases.
7510	binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
7511	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. srp9 together with srp14 and the alu portion of the srp rna, constitutes the elongation arrest domain of srp. the complex of srp9 and srp14 is required for srp rna binding.
7512	
7513	necessary for scanning and involved in initiation site selection. promotes the assembly of 48s ribosomal complexes at the authentic initiation codon of a conventional capped mrna.
7514	
7515	
7516	
7517	this protein is a component of ribonucleosomes. could be needed to organize a concentration gradient of a dorsalizing morphogen (dm) originating in the germinal vesicle. at least one of the isoforms is essential in somatic tissues.
7518	
7519	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to g(i)-alpha and g(o)-alpha, but not to g(s)-alpha (by similarity).
7520	major role in the synthesis of nucleoside triphosphates other than atp. the atp gamma phosphate is transferred to the ndp beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
7521	
7522	
7523	acyl-coa synthetase involved in bile acid metabolism. proposed to catalyze the first step in the conjugation of c24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their coa thioesters. seems to activate secondary bile acids entering the liver from the enterohepatic circulation. in vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (thca), the c27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
7524	
7525	thiol protease. key protease responsible for the removal of the invariant chain from mhc class ii molecules. the bond- specificity of this proteinase is in part similar to the specificities of cathepsin l and cathepsin n.
7526	
7527	
7528	
7529	
7530	
7531	promotes the exchange of ran-bound gdp by gtp. involved in the regulation of onset of chromosome condensation in the s phase. binds to the chromatin. rcc1/ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated dna.
7532	
7533	
7534	could participate in polarized transport, in the assembly and/or the activity of tight junctions.
7535	
7536	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
7537	
7538	promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including vega-a, vega-c, mmp1, mmp3, timp1, upa, pai-1 and integrins alpha-3 and alpha-5. cyr61-mediated gene regulation is dependent on heparin-binding. down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
7539	promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including vega-a, vega-c, mmp1, mmp3, timp1, upa, pai-1 and integrins alpha-3 and alpha-5. cyr61-mediated gene regulation is dependent on heparin-binding. down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
7540	required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier. functions as a homophilic cell-adhesion molecule. may play a role in early neuronal differentiation and axon outgrowth.
7541	
7542	
7543	
7544	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
7545	
7546	
7547	
7548	
7549	
7550	lysophoshatidylglycerol (lpg) specific acyltransferase that recognizes various acyl-coas and lpgs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-coas and oleoyl-coa as acyl donors. prefers oleoyl-lpg over palmitoyl-lpg as an acyl receptor and oleoyl-coa over lauroyl-coa as an acyl donor.
7551	putative receptor involved in the development of neural and epithelial tissues.
7552	could be a transcriptional activating factor. functions as a form of i-kappa-b specific for nf-kappa-b p50 subunit inhibiting its translocation to the nucleus.
7553	
7554	
7555	component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. nua4 may also play a direct role in dna repair when directly recruited to sites of dna damage.
7556	
7557	
7558	
7559	
7560	
7561	
7562	
7563	sequence-specific dna-binding transcription factor. binds to two specific dna sites located in the promoter region of hoxa4.
7564	
7565	pre-mrna processing factor involved in disassembly of spliceosomes after the release of mature mrna.
7566	recognizes the dna sequence 5@#$%&-attaa-3@#$%&. may play a role in hematopoietic differentiation.
7567	
7568	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release. has anti-apoptotic activity.
7569	in the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (krtap), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. the matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
7570	
7571	orphan receptor. interaction with rxr shifts rxr from its role as a silent dna-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by lxres. lxres are dr4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. plays an important role in the regulation of cholesterol homeostasis.
7572	protein transport. probably involved in vesicular traffic (by similarity).
7573	
7574	
7575	required for fusion of er-derived vesicles with the golgi during er-to-golgi protein transport. may be involved in proper membrane localization of rab gtpases.
7576	degrades extracellular matrix. proposed to play a role in breast cancer invasion and metastasis. exhibits trypsin-like activity as defined by cleavage of synthetic substrates with arg or lys as the p1 site.
7577	mediator of programmed cell death (apoptosis).
7578	
7579	
7580	
7581	
7582	clp cleaves peptides in various proteins in a process that requires atp hydrolysis. clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.
7583	functions as a component of the pcaf complex. the pcaf complex is capable of efficiently acetylating histones in a nucleosomal context. the pcaf complex could be considered as the human version of the yeast saga complex.
7584	
7585	
7586	
7587	creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
7588	
7589	also exhibits a dipeptidyl-peptidase iv type activity. in vitro, cleaves gly-pro-amc.
7590	
7591	binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
7592	receptor for class i mhc antigens. recognizes a broad spectrum of hla-a, hla-b, hla-c and hla-g alleles. involved in the down-regulation of the immune response and the development of tolerance. competes with cd8a for binding to class i mhc antigens. inhibits fcgr1a-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
7593	
7594	
7595	promotes apoptosis by activating caspases in the cytochrome c/apaf-1/caspase-9 pathway. acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (iap).
7596	
7597	atp-binding rna helicase involved in the biogenesis of 60s ribosomal subunits. required for the normal formation of 18s rrna through the processing of pre-rrnas at sites a0, a1 and a2, and the normal formation of 25s and 5.8s rrnas through the processing of pre-rrnas at sites c1 and c2.
7598	
7599	
7600	
7601	carries out a dual function: signal transduction and activation of transcription. involved in interleukin-4 signalling.
7602	
7603	
7604	may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. oas3 synthesizes preferentially dimeric 2@#$%&,5@#$%&-oligoadenylate molecules. gtp can be an alternative substrate.
7605	
7606	
7607	
7608	paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.
7609	
7610	receptor for tnfsf7/cd27l. may play a role in survival of activated t-cells. may play a role in apoptosis through association with siva.
7611	
7612	actin-binding protein involved in motile and morphological processes. inhibits actin polymerization, likely by sequestering g-actin. by capping the barbed ends of filaments, it also regulates motility. seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (by similarity).
7613	
7614	
7615	transcription factor involved in regulating gene activity following the primary growth factor response. binds to the dna sequence 5@#$%&-tga[cg]tca-3@#$%&.
7616	
7617	
7618	binds the poly(a) tail of mrna. may be involved in cytoplasmic regulatory processes of mrna metabolism. binds poly(a) with a slightly lower affinity as compared to pabpc1.
7619	
7620	
7621	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
7622	
7623	
7624	may be involved in the control of the cell cycle at the g1/s (start) and g2/m (mitosis) transitions. may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
7625	
7626	
7627	gtpase-activating protein for rho family members. may play a role in the reduction of the p21rasgtpase-activating potential of p120gap.
7628	type i collagen is a member of group i collagen (fibrillar forming collagen).
7629	docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. may serve as an activator of src and a downstream effector. interacts with the sh3 domain of fyn and with crk, src, and yes (by similarity).
7630	may inhibit cell replication either by catalyzing the oxidation of estrogen and androgen or by converting cortisone in cortisol.
7631	probable transcription factor.
7632	
7633	
7634	may play a role in cell cycle regulation. dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. interacts with cyclin- dependent kinases such as cdc2, cdk2 and cdk3. does not interact with cdk4.
7635	phosphorylase is an important allosteric enzyme in carbohydrate metabolism. enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. however, all known phosphorylases share catalytic and structural properties.
7636	
7637	
7638	may be involved in the regulation of the lipid composition of sperm membranes during the maturation in the epididymis (by similarity).
7639	
7640	responsible for the deiodination of t4 (3,5,3@#$%&,5@#$%&- tetraiodothyronine) into t3 (3,5,3@#$%&-triiodothyronine). essential for providing the brain with appropriate levels of t3 during the critical period of development.
7641	
7642	acts on galnac. also acts as a galactokinase when galactose is present at high concentrations.
7643	plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. localizes to the interzone of mitotic spindles.
7644	subunit of clathrin-associated adaptor protein complex 2 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. ap-2 complex seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface.
7645	cleaves the membrane-bound precursor of tnf-alpha at 76- ala-|-val-77 to its mature soluble form. responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-a2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (app). contributes to the normal cleavage of the cellular prion protein. involved in the cleavage of the adhesion molecule l1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. controls also the proteolytic processing of notch and mediates lateral inhibition during neurogenesis (by similarity).
7646	medin is the main constituent of aortic medial amyloid.
7647	
7648	target-derived survival factor for peripheral sensory sympathetic neurons.
7649	involved in regulation of the actin cytoskeleton. may regulate the was actin-bundling activity. bridges the interaction between abl1 and ptpn18 leading to the abl1 dephosphorylation. may play a role as a scaffold protein between ptpn12 and was and allows ptpn12 to dephosphorylate was. has the potential to physically couple cd2 and cd2ap to was. acts downstream of cd2 and cd2ap to recruit was to the t-cell:apc contact site so as to promote the actin polymerization required for synapse induction during t-cell activation (by similarity). down-regulates cd2- stimulated adhesion through the coupling of ptpn12 to cd2.
7650	
7651	
7652	may be involved in several stages of intracellular trafficking. plays a role in targeting ligand-activated egfr to the lysosomes for degradation after endocytosis from the cell surface and release from the golgi.
7653	inhibitor of hgf activator. also acts as an inhibitor of matriptase (st14).
7654	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l.
7655	
7656	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
7657	
7658	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
7659	tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. it seems to be required for cartilage and growth plate development.
7660	
7661	
7662	involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.
7663	
7664	
7665	cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases (by similarity).
7666	
7667	
7668	
7669	
7670	nmda receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine.
7671	
7672	
7673	
7674	couples signals from receptor and cytoplasmic tyrosine kinases to the ras signaling pathway.
7675	couples signals from receptor and cytoplasmic tyrosine kinases to the ras signaling pathway.
7676	seems to play a negative regulatory role in prpp synthesis.
7677	specific gef for rhoa activation and the regulation of vascular smooth muscle contractility.
7678	granulin-4 promotes proliferation of the epithelial cell line a431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
7679	
7680	
7681	collagen type ii is specific for cartilaginous tissues. it is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
7682	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
7683	
7684	
7685	involved in the initiation of dna replication. also participates in checkpoint controls that ensure dna replication is completed before mitosis is initiated.
7686	
7687	
7688	may function in the assembly or regulation of proteins in the cornified envelope. the lim domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.
7689	
7690	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
7691	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to both g(i)-alpha and g(q)- alpha (by similarity).
7692	potential tumor suppressor for renal cell carcinoma.
7693	may play a role in the response to environmental stress. appears to act upstream of the jun n-terminal pathway. may play a role in hematopoietic lineage decisions and growth regulation.
7694	
7695	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
7696	
7697	forms a voltage-independent potassium channel activated by intracellular calcium. activation is followed by membrane hyperpolarization. thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. the channel is blocked by apamin.
7698	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
7699	
7700	
7701	
7702	activates nf-kappa-b via bcl10.
7703	
7704	receptor for acidic and basic fibroblast growth factors. preferentially binds fgf1.
7705	
7706	putative odorant receptor.
7707	receptor for tnfsf8/cd30l. may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. regulates gene expression through activation of nf- kappa-b.
7708	
7709	
7710	
7711	
7712	
7713	
7714	
7715	
7716	
7717	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
7718	
7719	collagen type iv is specific for basement membranes. vital for embryonic development.
7720	muscle contraction.
7721	may be involved in transcriptional regulation.
7722	
7723	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
7724	
7725	type i collagen is a member of group i collagen (fibrillar forming collagen).
7726	
7727	
7728	putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. preferentially binds to alpha2,6-linked sialic acid. the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. in the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their sh2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. induces apoptosis in acute myeloid leukemia (in vitro).
7729	binds to pre-mrna. has high affinity for scaffold- attached region (sar) dna. bind to double- and single-stranded dna and rna.
7730	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to sites in the 5@#$%&-flanking sequence of its coding region with various affinities. the consensus sequences of the high and low affinity binding sites are 5@#$%&-taatga[cg]-3@#$%& and 5@#$%&-ctaatttt- 3@#$%&.
7731	membrane-bound, calcium-inhibitable adenylyl cyclase (by similarity).
7732	involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. may be involved in the release of components of the bilayered coat from the endosomal membrane. the association with escrt-iii complex mediates the atp- dependent disassembly of the escrt-iii complex. in case of infection, the hiv-1 virus takes advantage of it for budding and exocytic cargos of viral proteins.
7733	stimulates the transcription of various genes by recognizing and binding to a ccaat motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
7734	
7735	may act as a zinc-influx transporter.
7736	
7737	
7738	
7739	
7740	common junctional plaque protein. the membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. the presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.
7741	
7742	
7743	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
7744	polycomb group (pcg) protein. pcg proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. participates to the etv6-mediated repression. probably plays a role in cell proliferation. overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
7745	
7746	dorsalizing factor. key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing tgf-beta family bone morphogenetic proteins (bmps) and sequestering them in latent complexes (by similarity).
7747	
7748	implicated in the control of cell growth.
7749	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
7750	
7751	
7752	desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
7753	kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. phosphorylates preferentially transcription factor atf2.
7754	receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. plays an essential role in leukocyte migration (by similarity).
7755	plays a role in weight homeostasis. may play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding.
7756	
7757	
7758	
7759	
7760	may act as a protease inhibitor to modulate the host immune response against tumor cells.
7761	
7762	
7763	cysteine protease cleaving the c-terminal amino acid of atg8 to reveal a c-terminal glycine. atg8 ubiquitin-like activity requires the exposure of the glycine at the c-terminus for its conjugation to phosphatidylethanolamine and its insertion to membranes, which is necessary for autophagy. inhibited by n- ethylmaleimide.
7764	essential component of the nuclear pore complex. the n- terminal is probably involved in nucleocytoplasmic transport. the c-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex.
7765	
7766	interconversion of serine and glycine.
7767	probable transcription factor associated with development of alveolar rhabdomyosarcoma.
7768	seems to be involved in the cross-linking of microtubules and microfilaments.
7769	
7770	required for membrane traffic to the vacuole.
7771	
7772	receptor for lysophosphatidic acid (lpa), a mediator of diverse cellular activities. seems to be coupled to the g(i)/g(o), g(12)/g(13), and g(q) families of heteromeric g proteins.
7773	induces disassembly of actin filaments in conjunction with adf/cofilin family proteins (by similarity).
7774	induces disassembly of actin filaments in conjunction with adf/cofilin family proteins (by similarity).
7775	
7776	
7777	gtpase-activating protein for rac and cdc42. promotes the exchange of rac or cdc42-bound gdp by gtp, thereby activating them.
7778	
7779	may have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor.
7780	
7781	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
7782	guanine nucleotide exchange factor that interacts with rhoa, but not with rac or cdc42. activates rhoa to promote cytoskeletal contraction and inhibit neurite outgrowth.
7783	
7784	collagen type iv is specific for basement membranes.
7785	
7786	possesses two enzymatic activities: dna synthesis (polymerase) and an exonucleolytic activity that degrades single stranded dna in the 3@#$%& to 5@#$%& direction. required with its accessory proteins (proliferating cell nuclear antigen (pcna) and replication factor c (rfc) or activator 1) for leading strand synthesis. also involved in completing okazaki fragments initiated by the dna polymerase alpha/primase complex.
7787	possesses two enzymatic activities: dna synthesis (polymerase) and an exonucleolytic activity that degrades single stranded dna in the 3@#$%& to 5@#$%& direction. required with its accessory proteins (proliferating cell nuclear antigen (pcna) and replication factor c (rfc) or activator 1) for leading strand synthesis. also involved in completing okazaki fragments initiated by the dna polymerase alpha/primase complex.
7788	
7789	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
7790	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
7791	
7792	may antagonize nodal signaling and subsequent organization of axial structures during mesodermal patterning (by similarity).
7793	
7794	
7795	exhibits outward rectification in a physiological k(+) gradient and mild inward rectification in symmetrical k(+) conditions.
7796	could play a significant role in the signal transduction of hematopoietic cells. may regulate tyrosine kinase activity of src-family members in brain by specifically phosphorylating their c-terminal regulatory tyrosine residue which acts as a negative regulatory site. it may play an inhibitory role in the control of t-cell proliferation.
7797	
7798	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
7799	
7800	
7801	
7802	putative odorant receptor.
7803	
7804	
7805	transcriptional repressor.
7806	transcriptional repressor.
7807	does not bind dna by itself. recruits histone deacetylases and dna methyltransferases. acts as transcriptional repressor and plays a role in gene silencing.
7808	
7809	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
7810	
7811	the alpha-v integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von willebrand factor. they recognize the sequence r-g-d in a wide array of ligands.
7812	serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. promotes neurite extension by inhibiting thrombin. binds heparin.
7813	probable catalytic subunit of a gtpase activating protein that has specificity for rab3 subfamily (rab3a, rab3b, rab3c and rab3d). rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. specifically converts active rab3-gtp to the inactive form rab3-gdp. required for normal eye and brain development. may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and nonsynaptic vesicular release of neurotransmitters.
7814	transports the calcitonin gene-related peptide type 1 receptor (calcrl) to the plasma membrane. acts as a receptor for calcitonin-gene-related peptide (cgrp) together with calcrl.
7815	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
7816	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
7817	
7818	
7819	possibly involved in helper t-cell function.
7820	
7821	pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters. subunit of a quaternary complex that plays a central role in epithelial cell polarization.
7822	may be involved in transcriptional regulation.
7823	
7824	cbf binds to the core site, 5@#$%&-pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, lck, il-3 and gm-csf promoters.
7825	
7826	
7827	
7828	
7829	
7830	
7831	
7832	
7833	may be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.
7834	ena/vasp proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodelling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. enah induces the formation of f-actin rich outgrowths in fibroblasts. acts syngeristically with baiap2alpha and downstream of ntn1 to promote filipodia formation. required for the actin-based mobility of listeria monocytogenes (by similarity).
7835	binds gtp, gdp and gmp.
7836	
7837	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to g(i)-alpha and g(o)-alpha, but not to g(s)-alpha (by similarity).
7838	chemotactic activity for lymphocytes but not for monocytes or neutrophils.
7839	also functions as a glutathione peroxidase.
7840	
7841	
7842	serine/threonine protein kinase involved in regulating m phase functions during the cell cycle. may also be part of the signaling network controlling cellular adhesion. in vitro, is able to phosphorylate cdc25c and casein.
7843	transcription factor which binds specifically to the mef2 element present in the regulatory regions of many muscle- specific genes. activates transcription via this element. may be involved in muscle-specific and/or growth factor-related transcription.
7844	
7845	
7846	induces morphological reversion of a cell line transformed by a ras oncogene. counteracts the mitogenic function of ras, at least partly because it can interact with ras gaps and raf in a competitive manner.
7847	not known.
7848	
7849	amp deaminase plays a critical role in energy metabolism.
7850	
7851	involved in the inactivation of map kinases. has a specificity for the mapk11/mapk12/mapk13/mapk14 subfamily.
7852	
7853	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (by similarity).
7854	
7855	possible candidate as a tumor suppressor gene of neuroblastoma. may play an important role in preventing cells from entering the final stage (g1/s) of the transformation process.
7856	
7857	
7858	
7859	
7860	this enzyme participates in both the breakdown and synthesis of glucose.
7861	
7862	
7863	desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
7864	a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. in complex with slc9a3r1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. may play a role in the cellular mechanisms associated with multidrug resistance through its interaction with abcc2 and pdzk1ip1. may potentiate the cftr chloride channel activity. may function to connect scarb1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. may be involved in the regulation of proximal tubular na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (by similarity).
7865	binds medium- and long-chain acyl-coa esters with very high affinity and may function as an intracellular carrier of acyl-coa esters (by similarity). may be involved in energy metabolism in a manner that depends on the substrate used for energy production. dbi and its metabolites are involved in the regulation of multiple biological processes.
7866	catalyzes the trans-addition of the three molecules of ipp onto dmapp to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
7867	negatively regulates tgf-beta signaling.
7868	
7869	
7870	motor protein required for establishing a bipolar spindle. blocking of eg5 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.
7871	
7872	collagen type iv is specific for basement membranes. vital for embryonic development.
7873	
7874	may be involved in transcriptional regulation.
7875	essential bifunctional enzyme that catalyzes both the n- deacetylation and the n-sulfation of glucosamine (glcnac) of the glycosaminoglycan in heparan sulfate. modifies the glcnac-glca dissacharide repeating sugar backbone to make n-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. plays a role in determining the extent and pattern of sulfation of heparan sulfate.
7876	
7877	
7878	
7879	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release. has anti-apoptotic activity.
7880	
7881	involved in the repair of uv-damaged dna. binds to pyrimidine dimers.
7882	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
7883	acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.
7884	
7885	
7886	
7887	
7888	
7889	degrades casein, gelatins of types i, iii, iv, and v, and fibronectin. activates procollagenase.
7890	
7891	
7892	
7893	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
7894	
7895	
7896	may play a role in vesicular protein sorting, similar to the yeast retromer proteins (by similarity).
7897	
7898	
7899	
7900	involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
7901	
7902	may be involved in transcriptional regulation.
7903	
7904	could be involved in the hypothalamic regulation of body weight.
7905	binds to the basic helix-loop-helix protein tal-1. this interaction seems to be critical for the regulation of red blood cell development.
7906	
7907	
7908	
7909	
7910	xenin stimulates exocrine pancreatic secretion. it inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. in the gut, xenin interacts with the neurotensin receptor.
7911	regulator of notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. probably acts both as a positive and negative regulator of notch, depending on the developmental and cell context (by similarity). functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the notch pathway via some ubiquitin ligase activity.
7912	atp-dependent 3@#$%&-5@#$%& dna helicase, component of the core- tfiih basal transcription factor, involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. acts by opening dna either around the rna transcription start site or the dna damage.
7913	required for the production of circadian rhythms. the biological cycle depends on the rhythmic formation and nuclear localization of the tim-per complex. light induces the degradation of tim, which promotes elimination of per. nuclear activity of the heterodimer coordinatively regulates per and tim transcription through a negative feedback loop. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition.
7914	positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (mrlc). it prevents mir-mediated mrlc ubiquitination and its subsequent proteasomal degradation.
7915	
7916	lacks intrinsic gtpase activity. has a low affinity for gdp, and constitutively binds gtp. control rearrangements of the actin cytoskeleton. induces the rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.
7917	
7918	
7919	inhibitor of protein-phosphatase 1. this protein may be important in hormonal control of glycogen metabolism. hormones that elevate intracellular camp increase i-1 activity in many tissues. i-1 activation may impose camp control over proteins that are not directly phosphorylated by pka. following a rise in intracellular calcium, i-1 is inactivated by calcineurin (or pp2b). does not inhibit type-2 phosphatases.
7920	
7921	may be involved in cytokinesis, motility, and signal transduction (by similarity).
7922	
7923	
7924	
7925	receptor for the heterotrimeric lymphotoxin containing lta and ltb, and for tnfs14/light. promotes apoptosis via traf3 and traf5. may play a role in the development of lymphoid organs.
7926	
7927	
7928	
7929	
7930	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
7931	
7932	
7933	required for normal golgi function (by similarity).
7934	
7935	transcription factor that binds to gc box promoter elements. activates the transcription of these genes.
7936	
7937	
7938	
7939	may be involved in several stages of intracellular trafficking.
7940	
7941	
7942	binds to disheveled (dvl) and rho, and mediates wnt- induced dvl-rho complex formation. may play a role as a scaffolding protein to recruit rho-gdp and rho-gef, thereby, enhancing rho-gtp formation.
7943	centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. may also act as a centrosome maturation factor. may play a role in microtubule nucleation. overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules.
7944	
7945	
7946	
7947	
7948	thought to regulate cation conductance. may regulate accn1 and accn3 gating (by similarity).
7949	
7950	
7951	may function as an antagonist of fibroblast growth factor (fgf) pathways and may negatively modulate respiratory organogenesis.
7952	
7953	
7954	may be involved in cell adhesion processes, particularly in the central nervous system.
7955	can phosphorylate the alpha subunit of eif2 and may mediate translational control (by similarity).
7956	transcriptional factor which uses the canonical single or multiple carg boxes dna sequence. acts as a cofactor of serum response factor (srf) and has the potential to modulate srf-target genes. suppresses tnf-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. it may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (by similarity).
7957	
7958	
7959	
7960	
7961	adapter molecule for tnfrsf1a/tnfr1 that specifically associates with the cytoplasmic domain of activated tnfrsf1a/tnfr1 mediating its interaction with fadd. overexpression of tradd leads to two major tnf-induced responses, apoptosis and activation of nf-kappa-b.
7962	
7963	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
7964	
7965	collagen type ii is specific for cartilaginous tissues. it is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
7966	
7967	proton-conducting pore forming subunit of the membrane integral v0 complex of vacuolar atpase. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
7968	may play a role in 60s ribosomal subunit synthesis (potential).
7969	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
7970	could be involved in the unfolded protein response (upr) pathway. could enhance presenilin-mediated beta-amyloid protein 40 generation.
7971	sodium-dependent glucose transporter (by similarity).
7972	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i (by similarity).
7973	
7974	
7975	hcnp may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. hcnp increases the production of choline acetyltransferase but not acetylcholinesterase. seems to be mediated by a specific receptor (by similarity).
7976	
7977	
7978	
7979	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
7980	
7981	
7982	pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
7983	involved in axon growth. plays an essential role in neurite extension of cerebellar granule cells.
7984	
7985	component of the adaptor complexes which link clathrin to receptors in coated vesicles. clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. ap2b1 is a subunit of the plasma membrane adaptor. the complex binds polyphosphoinositides.
7986	component of the u5 snrnp complex required for pre-mrna splicing. binds gtp. interacts with prpf8.
7987	seems to act as a scaffold protein in multiple signaling pathways. modulates excitatory synaptic transmission and dendritic spine morphology. binds to actin filaments (f-actin) and shows cross-linking activity. binds along the sides of the f-actin. may play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. believed to target protein phosphatase 1/pp1 to dendritic spines, which are rich in f-actin, and regulates its specificity toward ion channels and other substrates, such as ampa-type and nmda-type glutamate receptors. plays a role in regulation of g-protein coupled receptor signaling, including dopamine d2 receptors and alpha- adrenergic receptors. may establish a signaling complex for dopaminergic neurotransmission through d2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. binds to adra1b and rgs2 and mediates regulation of adra1b signaling. may confer to rac signaling specificity by binding to both, racgefs and rac effector proteins. probably regulates p70 s6 kinase activity by forming a complex with tiam1.
7988	integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and cspg4. alpha- 3/beta-1 may mediate with lgals3 the stimulation by cspg4 of endothelial cells migration.
7989	chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. may be involved in b-cell migration into b-cell follicles in lymph nodes. attracts naive t-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive t-cells, cd4+ and cd8+ t-cells and thus may play a role in both humoral and cell-mediated immunity responses.
7990	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
7991	
7992	
7993	may act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. may be involved in epidermal cell adhesion and epidermal structure and function.
7994	may play a role in the signal transduction pathway mediated by multiple wnt genes.
7995	
7996	converts arachidonic acid to 15s- hydroperoxyeicosatetraenoic acid. also acts on c-12 of arachidonate as well as on linoleic acid.
7997	
7998	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
7999	may play a unique role in maintaining the normal corneal epithelial function (by similarity).
8000	receptor for adenosine. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
8001	nucleolin is the major nucleolar protein of growing eukaryotic cells. it is found associated with intranucleolar chromatin and preribosomal particles. it induces chromatin decondensation by binding to histone h1. it is thought to play a role in pre-rrna transcription and ribosome assembly.
8002	
8003	
8004	
8005	
8006	may be involved in transcriptional regulation.
8007	specialized low-affinity urea transporter. mediates urea transport in erythrocytes.
8008	may act as a protease inhibitor to modulate the host immune response against tumor cells.
8009	
8010	may be involved in transcriptional regulation.
8011	stimulates promoter activity in the presence of p49- and p50-nf-kappa-b. neither associates with dna nor with p65-nf-kappa- b.
8012	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
8013	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
8014	
8015	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
8016	binds to the fc region of monomeric immunoglobulins gamma. mediates the uptake of igg from milk. possible role in transfer of immunoglobulin g from mother to fetus.
8017	docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. dok1 appears to be a negative regulator of the insulin signaling pathway.
8018	could have a regulatory function in meiosis.
8019	troponin t is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin atpase activity.
8020	suppressor of clathrin deficiency.
8021	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling (by similarity).
8022	plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. binds to the photoreceptor conserved element-i (pce-1/ret 1) in the photoreceptor cell-specific arrestin promoter (by similarity).
8023	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
8024	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
8025	cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. may be involved in nervous system development.
8026	stimulates, in vitro and in vivo, the gtpase activity of rhoa.
8027	binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer.
8028	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
8029	
8030	transcriptional repressor.
8031	this protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.
8032	mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. also required for the transfer of beta-barrel precursors from the tom complex to the sorting and assembly machinery (sam complex) of the outer membrane. acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. the timm8-timm13 complex mediates the import of proteins such as timm23, slc25a12/aralar1 and slc25a13/aralar2, while the predominant timm9-timm10 70 kda complex mediates the import of much more proteins.
8033	
8034	camp-dependent and sulfonylurea-sensitive anion transporter. key gatekeeper influencing intracellular cholesterol transport.
8035	
8036	
8037	
8038	
8039	
8040	may have a function in migrating cells.
8041	
8042	stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. active in the presence of nad as cofactor but not in the presence of nadp.
8043	
8044	
8045	
8046	involved in the degradation of prenylated proteins. cleaves the thioether bond of prenyl-l-cysteines, such as farnesylcysteine and geranylgeranylcysteine.
8047	
8048	this protein is one of the chains of the nonenzymatic membrane component (f0) of mitochondrial atpase.
8049	
8050	
8051	inactivates histamine by n-methylation. plays an important role in degrading histamine and in regulating the airway response to histamine.
8052	may have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.
8053	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
8054	acts on tyrosine phosphorylated proteins, low-mw aryl phosphates and natural and synthetic acyl phosphates. isoform 3 does not possess phosphatase activity.
8055	atp-dependent rna helicase involved in 40s ribosomal subunit biogenesis. required for the processing and cleavage of 35s pre-rrna at sites a0, a1, and a2, leading to mature 18s rrna.
8056	
8057	catalyzes the cleavage of l-kynurenine (l-kyn) and l-3- hydroxykynurenine (l-3ohkyn) into anthranilic (aa) and 3- hydroxyanthranilic acids (3-ohaa), respectively. has a preference for the l-3-hydroxy form. also has cysteine-conjugate-beta-lyase activity (by similarity).
8058	
8059	
8060	proto-oncogene that may play a role in differentiation and lymphopoiesis. may function as a transcriptional transactivator.
8061	
8062	phosphorylates khdrbs1, khdrbs2, khdrbs3 and stap2/bks. may function as an intracellular signal transducer in epithelial tissues. overexpression in mammary cells leads to mitogenically sensitization to egf, and results in a partially transformed phenotype. its presence in the nucleus appears to be linked to suppression of tumor progression.
8063	receptor for tnfsf5/cd40lg.
8064	
8065	
8066	facilitative glucose transporter. this isoform may be responsible for constitutive or basal glucose uptake. has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
8067	
8068	initiates extracellular glutathione (gsh) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular gsh level. it is part of the cell antioxidant defense mechanism. catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. alternatively, glutathione can be hydrolyzed to give cys-gly and gamma glutamate.
8069	receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5), susceptibility to infection is correlated to its level of expression and availability at the plasma membrane of cells.
8070	
8071	
8072	complex that is thought to mediate chromatin assembly in dna replication and dna repair. assembles histone octamers onto replicating dna in vitro. caf-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones h3 and h4 to replicating dna; histones h2a/h2b can bind to this chromatin precursor subsequent to dna replication to complete the histone octamer. the ccr4-not complex functions as general transcription regulation complex.
8073	
8074	transcriptional regulator. may participate in transcriptional regulation through the recruitment of setdb1 histone methyltransferase and subsequent modification of local chromatin structure.
8075	an integral component of the pericentriolar material (pcm).
8076	
8077	required for initiation of chromosomal dna replication.
8078	dephosphorylates and concomitantly deactivates cam- kinase ii activated upon autophosphorylation, and cam-kinases iv and i activated upon phosphorylation by cam-kinase kinase. promotes apoptosis.
8079	may play an important role in the progression of epithelial malignancies.
8080	
8081	
8082	
8083	may have transport activity.
8084	
8085	type i collagen is a member of group i collagen (fibrillar forming collagen).
8086	
8087	may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
8088	
8089	tumor suppressor that may be involved in interferon- dependent cell death (by similarity).
8090	
8091	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
8092	
8093	
8094	
8095	might be involved in transcellular transport (by similarity).
8096	
8097	
8098	
8099	
8100	transcriptional regulator that probably plays an important role in lymphomagenesis.
8101	hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. displays very low levels of activity. associates with and negatively regulates mst1r.
8102	specifically binds poly(g) rna homopolymers in vitro.
8103	visual pigments are the light-absorbing molecules that mediate vision. they consist of an apoprotein, opsin, covalently linked to cis-retinal.
8104	receptor for sema4d. plays a role in rhoa activation and subsequent changes of the actin cytoskeleton. plays a role in axon guidance, invasive growth and cell migration.
8105	
8106	hydrolysis of urea to ammonia and co2.
8107	
8108	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
8109	activates hepatocyte growth factor (hgf) by converting it from a single chain to a heterodimeric form.
8110	
8111	
8112	
8113	
8114	the enzyme cleaves lys-arg and arg-ser bonds. it activates, in a reciprocal reaction, factor xii after its binding to a negatively charged surface. it also releases bradykinin from hmw kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
8115	stimulates gdp/gtp exchange reaction of a group of small gtp-binding proteins (g proteins) including rap1a/rap1b, rhoa, rhob and kras, by stimulating the dissociation of gdp from and the subsequent binding of gtp to each small g protein.
8116	removes residual c-terminal arg or lys remaining after initial endoprotease cleavage during prohormone processing. processes proinsulin.
8117	
8118	required for ribosome biogenesis. part of a complex which catalyzes pseudouridylation of rrna. this involves the isomerization of uridine such that the ribose is subsequently attached to c5, instead of the normal n1. pseudouridine (@#$%!psi@#$%!) residues may serve to stabilize the conformation of rrnas. essential for growth.
8119	may be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
8120	
8121	
8122	binds with high affinity to rna molecules that contain au-rich elements (ares) found within the 3-prime untranslated regions of many protooncogenes and cytokine mrnas. also binds to double- and single-stranded dna sequences in a specific manner and functions a transcription factor. each of the rna-binding domains specifically can bind solely to a single-stranded non-monotonous 5@#$%&-uuag-3@#$%& sequence and also weaker to the single-stranded 5@#$%&- ttaggg-3@#$%& telomeric dna repeat. binding of rrm1 to dna inhibits the formation of dna quadruplex structure which may play a role in telomere elongation. may be involved in translationally coupled mrna turnover. implicated with other rna-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding-region determinant of instability (mcrd) domain.
8123	
8124	
8125	
8126	
8127	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
8128	
8129	initiates complex n-linked carbohydrate formation. essential for the conversion of high-mannose to hybrid and complex n-glycans.
8130	
8131	
8132	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
8133	specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3@#$%&end of 16s rrna in the 30s particle. its inactivation leads to kasugamycin resistance.
8134	
8135	may act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
8136	regulator of vesicular trafficking process. required for the sorting of endocytic (egf receptors) cargos. also involved in exocytic cargos of viral proteins of hiv-1 virus. in case of infection by hiv-1 virus, it is recruited to and functions at sites of viral gag assembly and budding. may be involved in cell growth and differentiation. acts as a negative growth regulator.
8137	
8138	may play a role in growth regulation. is associated with g2/m phase arrest in response to dna damage. may be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (by similarity).
8139	
8140	may play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.
8141	associates with the cytoplasmic domain of a variety of cadherins. the association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. may play a crucial role in cell differentiation.
8142	
8143	
8144	beta-endorphin and met-enkephalin are endogenous opiates.
8145	integrin alpha-1/beta-1 is a receptor for laminin and collagen. it recognizes the proline-hydroxylated sequence g-f-p-g- e-r in collagen.
8146	
8147	may function as a nuclear transport receptor (by similarity).
8148	involved in the transport of chloride ions. may regulate bicarbonate secretion and salvage in epithelial cells by regulating the slc4a7 transporter.
8149	transports cmp-sialic acid from the cytosol into golgi vesicles where glycosyltransferases function.
8150	
8151	the enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin k-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
8152	
8153	involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with mhc class i molecules. also acts as a molecular scaffold for the final stage of mhc class i folding, namely the binding of peptide. nascent mhc class i molecules associate with tap via tapasin. inhibited by the covalent attachment of herpes simplex virus icp47 protein, which blocks the peptide-binding site of tap. inhibited by human cytomegalovirus us6 glycoprotein, which binds to the lumenal side of the tap complex and inhibits peptide translocation by specifically blocking atp-binding to tap1 and prevents the conformational rearrangement of tap induced by peptide binding. inhibited by human adenovirus e3-19k glycoprotein, which binds the tap complex and acts as a tapasin inhibitor, preventing mhc class i/tap association. expression of tap1 is down-regulated by human epstein-barr virus vil-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by mhc class i molecules.
8154	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
8155	
8156	
8157	
8158	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
8159	
8160	
8161	transcription factor that binds to the octamer motif (5@#$%&-atttgcat-3@#$%&). prime candidate for an early developmental control gene.
8162	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
8163	this protein is associated with snrnp u1.
8164	core tafii present in both of the previously described tfiid species which either lack or contain tafii30 (tfiid alpha and tfiid beta respectively).
8165	may be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to dna damage. binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
8166	
8167	
8168	
8169	may be involved in the control of camp-mediated neural activity and camp metabolism in the brain.
8170	required for imaginal cell differentiation, may be involved in hormonal responsiveness during metamorphosis. involved in an inhibitory signaling mechanism to determine the number of cells that will form unicellular sprouts in the trachea. regulated by transcription factor esg. the longer hdc protein is completely functional and the shorter protein carries some function.
8171	
8172	
8173	id (inhibitor of dna binding) hlh proteins lack a basic dna-binding domain but are able to form heterodimers with other hlh proteins, thereby inhibiting dna binding.
8174	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules (by similarity).
8175	probable motor protein.
8176	
8177	sugar transporter that specifically mediates the transport of udp-xylose (udp-xyl) and udp-n-acetylglucosamine (udp-glcnac) from cytosol into golgi.
8178	
8179	
8180	may be involved in transcriptional regulation.
8181	arm and abl proteins function cooperatively at adherens junctions in both the cns and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone@#$%&s response to midline cues. the ability of pcc/mp2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both slit/robo and abl-dependent signaling pathways.
8182	
8183	
8184	
8185	
8186	
8187	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
8188	
8189	
8190	involved in regulation of adherens junction between cells. functions as a guanine nucleotide exchange factor (gef), which activates rap1 small gtpase by exchanging bound gdp for free gtp.
8191	essential component of the scf (skp1-cul1-f-box protein) e3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. in the scf complex, serves as a rigid scaffold that organizes the skp1-f-box protein and rbx1 subunits. may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
8192	
8193	plays an important role in the differentiation and development of pancreatic islet beta cells. transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. competes with pax6 for this same promoter binding site. the pax4v isoform appears to be a dominant negative form antagonizing pax4 transcriptional activity.
8194	required for vesicular transport from the er to the golgi complex. functions as a snare involved in the docking process of er-derived vesicles with the cis-golgi membrane (by similarity).
8195	
8196	
8197	
8198	
8199	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters.
8200	
8201	converts hdl into larger and smaller particles. may play a key role in extracellular phospholipid transport and modulation of hdl particles.
8202	stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. may bind polyunsaturated fatty acids.
8203	high specificity for fatty acids. highest affinity for c18 chain length. decreasing the chain length or introducing double bonds reduces the affinity. may be involved in keratinocyte differentiation.
8204	
8205	general coactivator that functions cooperatively with tafs and mediates functional interactions between upstream activators and the general transcriptional machinery. binds single-stranded dna.
8206	negatively regulates tyrosine hydroxylase activity.
8207	
8208	
8209	
8210	
8211	protein kinase that plays an important role in cellular stress response. activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic foxo3a. phosphorylates nedd4l, which leads to its inactivation and to the subsequent activation of various channels and transporters such as enac, kv1.3, or eaat1.
8212	the elongin bc complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different e3 ubiquitin ligase complexes, including the von hippel-lindau ubiquitination complex cbc(vhl). by binding to bc- box motifs it seems to link target recruitment subunits, like vhl and members of the socs box family, to cullin/rbx1 modules that activate e2 ubiquitination enzymes.
8213	forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (by similarity).
8214	binds to tie2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. its function may be context-dependent. in the absence of angiogenic inducers, such as vegf, ang2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. in concert with vegf, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
8215	
8216	member of the machinery of polarized transport. required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.
8217	
8218	
8219	
8220	adf augments the expression of the interleukin-2 receptor tac (il2r/p55).
8221	
8222	involved in dna excision repair. initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region.
8223	required for the binding of mrna to ribosomes. functions in close association with eif4-f and eif4-a. binds near the 5@#$%&- terminal cap of mrna in presence of eif-4f and atp. promotes the atpase activity and the atp-dependent rna unwinding activity of both eif4-a and eif4-f.
8224	induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
8225	
8226	
8227	
8228	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain (by similarity).
8229	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
8230	transcriptional coactivator stimulating nr5a1 and ligand-dependent nr1h3/lxra and pparg transcriptional activities. enhances the dna-binding activity of atf1, atf2, creb1 and nr5a1. regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. may function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
8231	
8232	co-chaperone of hsc70. seems to play a role in protein import into mitochondria.
8233	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
8234	
8235	probably involved in iron homeostasis.
8236	involved in the synthesis of the gdp-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
8237	
8238	clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
8239	converts arachidonic acid exclusively to 15s- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized.
8240	
8241	protein kinase that act on both serine and threonine residues.
8242	
8243	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
8244	
8245	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
8246	
8247	
8248	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
8249	
8250	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
8251	
8252	stimulates a migratory response in cd4+ lymphocytes, monocytes, and eosinophils. also induces t-lymphocyte expression of interleukin 2 receptor. ligand for cd4.
8253	
8254	
8255	
8256	
8257	
8258	
8259	
8260	nuclear hormone receptor. the steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
8261	
8262	
8263	the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the er, via the golgi up to the trans golgi network. coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-er transport of dilysine-tagged proteins. in mammals, the coatomer can only be recruited by membranes associated to adp-ribosylation factors (arfs), which are small gtp-binding proteins; the complex also influences the golgi structural integrity, as well as the processing, activity, and endocytic recycling of ldl receptors (by similarity).
8264	
8265	plays a role in signal transduction in blood cells. contributes to both cell proliferation and survival and thus provide a selective advantage in tumorigenesis.
8266	has an important function as a repair enzyme for proteins that have been inactivated by oxidation. catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
8267	accepts electrons from etf and reduces ubiquinone.
8268	
8269	
8270	shows weak transcriptional activatory activity.
8271	this protein has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. seems to be identical to the elastin-binding protein (ebp), a major component of the non- integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. in elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.
8272	this protein has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. seems to be identical to the elastin-binding protein (ebp), a major component of the non- integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. in elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.
8273	
8274	
8275	tyrosine kinase, that after binding to cdc42, inhibits both its intrinsic and stimulated gtpase activity.
8276	
8277	
8278	mediates electroneutral potassium-chloride cotransport when activated by cell swelling. may mediate k(+) uptake into deiters@#$%& cells in the cochlea and contribute to k+ recycling in the inner ear. important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of corti. may be required for basolateral cl(-) extrusion in the kidney and contribute to renal acidification (by similarity).
8279	phosphorylates on ser and thr residues the goodpasture autoantigen (in vitro). isoform 2 seems to be less active.
8280	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&. activates transcription of pf4 in complex with meis1.
8281	
8282	
8283	
8284	
8285	may regulate transcriptional activity.
8286	vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
8287	type i collagen is a member of group i collagen (fibrillar forming collagen).
8288	adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. can bind to fibrinogen, fibronectin, laminin and type v collagen.
8289	transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. it appears that leucine is the preferred substrate, but all large neutral non-aromatic l-amino acids bind to this transporter. uptake of leucine is sodium- dependent. in contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (by similarity).
8290	
8291	complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. also mediates erythropoiesis in vitro; but, unlike il-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. known to act on mmp-1, mmp-2, mmp-3, mmp-7, mmp-8, mmp-9, mmp-10, mmp-11, mmp-12, mmp-13 and mmp-16. does not act on mmp-14.
8292	dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. could be involved in a signal transduction pathway necessary for late myogenesis, although its ubiquitous expression suggests a wider function.
8293	may suppress the ability of pou3f2 to transactivate the drd1 gene in a pou3f2 dependent manner. can activate transcription directly or via association with the transcription machinery. may be involved in atxn1 mutant-induced cell death. the interaction with atxn1 mutant reduces levels of phosphorylated rna polymerase ii large subunit.
8294	
8295	
8296	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
8297	
8298	
8299	
8300	may eliminate potentially toxic dinucleoside polyphosphates during sporulation. most active against diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p6-hexaphosphate (ap6a). can also hydrolyze diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p5-pentaphosphate (ap5a), adenosine 5@#$%&-pentaphosphate, and adenosine 5@#$%&-tetraphosphate are also substrates, but not diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p4-tetraphosphate (ap4a) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. also cleaves a beta-phosphate from the diphosphate groups in pp-insp5 (diphosphoinositol pentakisphosphate) and [pp]2-insp4 (bisdiphosphoinositol tetrakisphosphate).
8301	
8302	
8303	functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. upon ligand activation through the released notch intracellular domain (nicd) it forms a transcriptional activator complex with rbp-j kappa and activates genes of the enhancer of split locus. affects the implementation of differentiation, proliferation and apoptotic programs (by similarity). may play a role during cns development.
8304	binds to 5s ribosomal rna (by similarity).
8305	
8306	
8307	
8308	high-affinity self-ligand important in bidirectional t- cell to b-cell stimulation. slam-induced signal-transduction events in t-lymphocytes are different from those in b-cells. two modes of slam signaling are likely to exist: one in which the inhibitor sh2d1a acts as a negative regulator and another in which protein-tyrosine phosphatase 2c (ptpn11)-dependent signal transduction operates.
8309	high-affinity self-ligand important in bidirectional t- cell to b-cell stimulation. slam-induced signal-transduction events in t-lymphocytes are different from those in b-cells. two modes of slam signaling are likely to exist: one in which the inhibitor sh2d1a acts as a negative regulator and another in which protein-tyrosine phosphatase 2c (ptpn11)-dependent signal transduction operates.
8310	removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. prefers acyl chain lengths of 14 to 18 carbons.
8311	cross-linked envelope protein of keratinocytes. it is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. all that results in the formation of an insoluble envelope beneath the plasma membrane.
8312	
8313	
8314	
8315	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
8316	
8317	
8318	part of a post-splicing multiprotein complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity (by similarity).
8319	binds gtp, gdp and gmp.
8320	anti-proliferative protein. modulates transcription regulation mediated by esr1.
8321	interferes with cbl-mediated down-regulation and degradation of receptor-type tyrosine kinases. promotes accumulation of activated target receptors, such as t-cell receptors, egfr and pdgfrb, on the cell surface.
8322	
8323	
8324	an integral component of the pericentriolar material (pcm).
8325	probable glycosyltransferase (by similarity).
8326	
8327	
8328	
8329	
8330	
8331	
8332	involved in mediating interferon-gamma-induced cell death.
8333	plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-rna interactions required for accurate 3@#$%& splice site selection. recruits u2 snrnp to the branch point. directly mediates interactions between u2af2 and proteins bound to the enhancers and thus may function as a bridge between u2af2 and the enhancer complex to recruit it to the adjacent intron.
8334	
8335	spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. it associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
8336	not known.
8337	tafs are components of the transcription factor iid (tfiid) complex, pcaf histone acetylase complex and tbp-free tafii complex (tftc). tafs components-tiifd are essential for mediating regulation of rna polymerase transcription.
8338	ras proteins bind gdp/gtp and possess intrinsic gtpase activity.
8339	the association of the dr1/drap1 heterodimer with tbp results in a functional repression of both activated and basal transcription of class ii genes. this interaction precludes the formation of a transcription-competent complex by inhibiting the association of tfiia and/or tfiib with tbp. can bind to dna on its own.
8340	catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. in intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (by similarity).
8341	plays a major role in tight junction-specific obliteration of the intercellular space (by similarity).
8342	
8343	transcriptional activator. binds to fat body-specific enhancers of alcohol dehydrogenase (adh) and yolk protein genes. bbf-2 may play a role in fat body gene expression. it binds the consensus sequence 5@#$%&-t[ac]nacgtan[tg]c-3@#$%&.
8344	
8345	p53-regulated inhibitor of g2/m progression.
8346	
8347	catalyzes the formation of fatty acid-cholesterol esters. plays a role in lipoprotein assembly and dietary cholesterol absorption. in addition to its acyltransferase activity, it may act as a ligase.
8348	highly potent vasoconstrictor.
8349	reversible hydration of carbon dioxide. may stimulate the sodium/bicarbonate transporter activity of slc4a4 (by similarity).
8350	receptor for the fc region of complexed immunoglobulins gamma. low affinity receptor.
8351	plays an important role in spindle pole orientation. interacts and contributes to the functional activity of g(i) alpha proteins. acts to stabilize the apical complex during neuroblast divisions.
8352	
8353	
8354	
8355	involved in molybdenum cofactor biosynthesis.
8356	
8357	
8358	microtubule-based anterograde translocator for membranous organelles. plus end-directed microtubule sliding activity in vitro.
8359	
8360	terminal component of the liver microsomal stearyl-coa desaturase system, that utilizes o(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-coa substrates including palmitoyl-coa and stearoyl-coa.
8361	
8362	
8363	produces atp from adp in the presence of a proton gradient across the membrane. the gamma chain is believed to be important in regulating atpase activity and the flow of protons through the cf(0) complex.
8364	
8365	
8366	may play a role in the cellular processing of insulin. may be involved in intercellular peptide signaling.
8367	does not act as an allosteric activator of the cholera toxin catalytic subunit.
8368	
8369	involved in redox regulation of the cell. protects radical-sensitive enzymes from oxidative damage by a radical- generating system. acts synergistically with map3k13 to regulate the activation of nf-kappa-b in the cytosol.
8370	may play a role in targeting hzw10 to the kinetochore at prometaphase. part of the mis12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis.
8371	transcriptional activator (by similarity). binds a gc box motif. could play a role in b-cell growth and development.
8372	
8373	
8374	
8375	corepressor targeting diverse transcription regulators (by similarity).
8376	responsible for synthesis of pseudouridine from uracil- 55 in the psi gc loop of transfer rnas.
8377	
8378	
8379	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
8380	
8381	the substrate transported is not yet known. induces mitochondrial depolarization.
8382	not known, could be a tyrosine-phosphatase.
8383	part of a post-splicing multiprotein complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity (by similarity).
8384	
8385	promotes the exchange of ras-bound gdp by gtp. this protein positively controls the level of cellular camp at start, the stage at which the yeast cell division cycle is triggered.
8386	ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. can affect ras signaling at different levels. first, by competing with raf1 protein for binding to activated ras. second, by enhancing signaling from abl1 and abl2, which regulate cytoskeletal remodeling. third, by activating rab5a, possibly by functioning as a guanine nucleotide exchange factor (gef) for rab5a, by exchanging bound gdp for free gtp, and facilitating ras-activated receptor endocytosis.
8387	
8388	
8389	converts prothrombin to thrombin.
8390	thiol protease that cleaves il-1 beta between an asp and an ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
8391	
8392	catalyzes the transfer of mannose from dol-p-man to lipid-linked oligosaccharides.
8393	likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the rxxx[kr]r consensus motif.
8394	possibly acts as a transcriptional regulatory factor.
8395	may be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus.
8396	component of the asymmetric unit membrane (aum); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. may play an important role in regulating the assembly of the aum (by similarity).
8397	serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
8398	mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. may also be required for the transfer of beta-barrel precursors from the tom complex to the sorting and assembly machinery (sam complex) of the outer membrane. acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
8399	vitamin b12-binding protein. transports cobalamin into cells.
8400	
8401	
8402	
8403	
8404	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. plays a critical role in retinal angiogenesis.
8405	
8406	associates with the ef-tu.gdp complex and induces the exchange of gdp to gtp. it remains bound to the aminoacyl-trna.ef- tu.gtp complex up to the gtp hydrolysis stage on the ribosome (by similarity).
8407	
8408	
8409	
8410	acts as a low affinity receptor for nicotinic acid and mediate its anti-lipolytic effect through a g(i)-protein-mediated inhibition of adenylyl cyclase. this pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
8411	involved in the regulation of structural processes in differentiating and mature neuronal cells (by similarity).
8412	binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
8413	
8414	
8415	
8416	may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.
8417	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
8418	binds to p-, e- and l-selectins. the calcium-dependent high affinity interaction with p-selectin mediates the tethering and rolling of neutrophils and t-lymphocytes on endothelial cells.
8419	
8420	this potassium channel is controlled by g proteins. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. can be blocked by external barium (by similarity).
8421	
8422	the s.cerevisiae ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-amp.
8423	
8424	
8425	
8426	
8427	
8428	
8429	
8430	copper chaperone for cytochrome c oxidase (cox). binds two copper ions and deliver them to the cu(a) site of cox (by similarity).
8431	functions in segment determination through interaction with genes of bithorax (bx-c) and antennapedia (ant-c) complexes. it can behave as an activator of bx-c. involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. shown to bind zinc (in vitro).
8432	
8433	
8434	
8435	type iv collagen is the major structural component of glomerular basement membranes (gbm), forming a @#$%&chicken-wire@#$%& meshwork together with laminins, proteoglycans and entactin/nidogen.
8436	
8437	
8438	
8439	suppresses neurite outgrowth (by similarity).
8440	
8441	
8442	controls reversibly actin polymerization and depolymerization in a ph-sensitive manner. it has the ability to bind g- and f-actin in a 1:1 ratio of cofilin to actin. it is the major component of intranuclear and cytoplasmic actin rods (by similarity).
8443	implicated in immunoproteasome assembly and required for efficient antigen processing. the pa28 activator complex enhances the generation of class i binding peptides by altering the cleavage pattern of the proteasome.
8444	transcription regulatory factor that mediates signaling by type i ifns (ifn-alpha and ifn-beta). following type i ifn binding to cell surface receptors, jak kinases (tyk2 and jak1) are activated, leading to tyrosine phosphorylation of stat1 and stat2. the phosphorylated stats dimerize, associate with isgf3g/irf-9 to form a complex termed isgf3 transcription factor, that enters the nucleus. isgf3 binds to the ifn stimulated response element (isre) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
8445	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression.
8446	binds to the il-1 type i receptor following il-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mrna stabilization. isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for il-1 signaling. once phosphorylated, irak1 recruits the adapter protein peli1.
8447	
8448	catalyzes an essential step in the conversion of oligo- mannose to complex n-glycans.
8449	
8450	catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. responsible for cross- linking epidermal proteins during formation of the stratum corneum.
8451	
8452	fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. fibrillin-1- containing microfibrils provide long-term force bearing structural support.
8453	
8454	
8455	
8456	essential for the control of the cell cycle at the g2/m (mitosis) transition.
8457	
8458	type i collagen is a member of group i collagen (fibrillar forming collagen).
8459	
8460	
8461	
8462	
8463	
8464	transcriptional repressor of genes that require a bhlh protein for their transcription. may act as a negative regulator of myogenesis by inhibiting the functions of myod1 and ash1 (by similarity).
8465	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
8466	
8467	unknown, though mvp is required for normal vault structure. vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport.
8468	
8469	
8470	
8471	
8472	could promote homologous recombination at sites of dna damage. rrp1 has apurinic endonuclease and double-stranded dna 3@#$%& exonuclease, activities and carries out single-stranded dna renaturation in a mg(2+)-dependent manner.
8473	phosphorylates and activates not only pkb/akt, but also pka, pkc-zeta, p70s6k and p90s6k/rsk. may play a general role in signaling processes and in development (by similarity). isoform 3 is catalytically inactive.
8474	
8475	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
8476	may be involved in transcriptional regulation.
8477	may be involved in transcriptional regulation.
8478	docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. implicated in induction of cell migration. overexpression confers antiestrogen resistance on breast cancer cells.
8479	
8480	integrin alpha-6/beta-4 is a receptor for laminin. it plays a critical structural role in the hemidesmosome of epithelial cells.
8481	
8482	
8483	
8484	
8485	
8486	transfers a sulfuryl group to an n-unsubstituted glucosamine linked to a 2-o-sulfo iduronic acid unit on heparan sulfate. catalyzes the o-sulfation of glucosamine in idoua2s-glcns and also in idoua2s-glcnh2. the substrate-specific o-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to herpes simplex virus-1 (hsv-1) and permits its entry. unlike 3-ost-1, does not convert nonanticoagulant heparan sulfate to anticoagulant heparan sulfate.
8487	functions as a histone acetyltransferase (hat) to promote transcriptional activation. acetylation of histones gives a specific tag for epigenetic transcription activation. has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles.
8488	component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix.
8489	
8490	
8491	may play a role in germ line formation.
8492	
8493	
8494	
8495	
8496	atp citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-coa in many tissues. has a central role in de novo lipid synthesis. in nervous tissue it may be involved in the biosynthesis of acetylcholine.
8497	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
8498	
8499	the smn complex plays an essential role in spliceosomal snrnp assembly in the cytoplasm and is required for pre-mrna splicing in the nucleus.
8500	the smn complex plays an essential role in spliceosomal snrnp assembly in the cytoplasm and is required for pre-mrna splicing in the nucleus.
8501	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to g(t)-alpha. involved in phototransduction; key element in the recovery phase of visual transduction (by similarity).
8502	probably involved in the organization of the actin cytoskeleton. may act downstream of cdc42 to induce actin filament assembly leading to cell shape changes. induces pseudopodia formation, when overexpressed in fibroblasts.
8503	
8504	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
8505	catalyzes the removal of elemental sulfur from cysteine to produce alanine. it supplies the inorganic sulfur for iron- sulfur (fe-s) clusters.
8506	
8507	involved in the release of sentrins (potential).
8508	directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.
8509	is able to inhibit all four classes of proteinases by a unique @#$%&trapping@#$%& mechanism. this protein has a peptide stretch, called the @#$%&bait region@#$%& which contains specific cleavage sites for different proteinases. when a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. the entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
8510	
8511	molecular calcium binding chaperone promoting folding, oligomeric assembly and quality control in the er via the calreticulin/calnexin cycle. this lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the er. interacts with the dna-binding domain of nr3c1 and mediates its nuclear export.
8512	type i collagen is a member of group i collagen (fibrillar forming collagen).
8513	orphan receptor. binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5@#$%&-aggtca-3@#$%& and 4-nt spacing (dr-4).
8514	
8515	
8516	binds specifically to phosphatidylinositol-3-phosphate (ptdins3p), but not to other phosphoinositides.
8517	
8518	
8519	
8520	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins. necessary for activation of the cdc28 kinase.
8521	forms a voltage-independent potassium channel that is activated by intracellular calcium. activation is followed by membrane hyperpolarization which promotes calcium influx. the channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
8522	
8523	the function of brain maps is essentially unknown. phosphorylated map1b may play a role in the cytoskeletal changes that accompany neurite extension. possibly map1b binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules.
8524	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
8525	may play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. required for sperm motility and male fertility (by similarity).
8526	regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction.
8527	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
8528	binds specifically to peptidoglycan and is involved in innate immunity.
8529	transcriptional repressor.
8530	heterodimers between tcf3 and tissue-specific basic helix-loop-helix (bhlh) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early b-cell differentiation. dimers bind dna on e-box motifs: 5@#$%&- canntg-3@#$%&. binds to the kappa-e2 site in the kappa immunoglobulin gene enhancer.
8531	
8532	
8533	implicated in brca1-mediated tumor suppression. may, as part of the rna polymerase-2 holoenzyme, function in the cellular response to dna damage. in vitro, inhibits pre-mrna 3@#$%& cleavage.
8534	necessary for sperm flagellar function.
8535	thought to stabilize the calcium channel in an inactivated (closed) state (by similarity). modulates calcium current when coexpressed with cacna1g.
8536	
8537	mediates odorant detection (possibly) via modulation of intracellular camp concentration.
8538	may have a functional role during normal fetal development.
8539	
8540	
8541	receptor for interleukin-1 alpha (il-1a), beta (il-1b), and interleukin-1 receptor antagonist protein (il-1ra). binding to the agonist leads to the activation of nf-kappa-b. signaling involves formation of a ternary complex containing il1rap, tollip, myd88, and irak1 or irak2.
8542	this is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of na(+) and k(+) ions across the plasma membrane. the exact function of the beta-3 subunit is not known.
8543	carries out a dual function: signal transduction and activation of transcription. involved in il12 signaling.
8544	
8545	
8546	plays an important role in the organization of the cytoskeleton. binds to and sequesters actin monomers (g actin) and therefore inhibits actin polymerization (by similarity).
8547	promotes guanine-nucleotide exchange on arf1. promotes the activation of arf through replacement of gdp with gtp.
8548	
8549	
8550	may be involved in embryonic development.
8551	acts both in vulval induction and sex myoblast migration. presumably interacts with the kinase receptor let-23 and with a target that modifies the ras-like protein let-60.
8552	catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
8553	
8554	
8555	
8556	acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin g. may prevent elastase-mediated damage to oral and possibly other mucosal tissues (by similarity).
8557	transfers mannose from gdp-mannose to dolichol monophosphate to form dolichol phosphate mannose (dol-p-man) which is the mannosyl donor in pathways leading to n-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and o- mannosylation of proteins.
8558	
8559	induces cartilage and bone formation. may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. plays a role in calcium regulation and bone homeostasis.
8560	
8561	binds to tyrosine-protein kinase receptor tie2 and activates it.
8562	
8563	
8564	acts as a factor that allows the dna to undergo a single round of replication per cell cycle. required for dna replication and cell proliferation.
8565	inhibits papain and cathepsin l but with affinities lower than other cystatins. may play a role in immune regulation through inhibition of a unique target in the hematopoietic system.
8566	
8567	promotes cell adhesion (by similarity).
8568	
8569	required for synthesis of pyridoxal-5-phosphate from vitamin b6.
8570	may play a role in cell motility and cell adhesion.
8571	
8572	dephosphorylates and concomitantly deactivates cam- kinase ii activated upon autophosphorylation, and cam-kinases iv and i activated upon phosphorylation by cam-kinase kinase. promotes apoptosis.
8573	
8574	
8575	may play a role in cell proliferation, differentiation and death.
8576	
8577	
8578	has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. could be involved in the resistance to anti-tumor agents. possesses a dithiol-reducing activity.
8579	probably involved in translation.
8580	the l3 protein is a component of the large subunit of cytoplasmic ribosomes.
8581	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
8582	
8583	
8584	major component of the descemet@#$%&s membrane (basement membrane) of corneal endothelial cells.
8585	involved in the repair of mismatches in dna.
8586	receptor for ccl2, ccl8, ccl13, ccl19, ccl21 and ccl25.
8587	may play a role in the antiviral response of interferon (ifn) by amplifying and enhancing the ifn response through increased expression of select subset of potent antiviral genes. may contribute to cytokine-regulated cell proliferation and differentiation.
8588	
8589	may play a role in binding dynein to membranous organelles or chromosomes. may associate with the heavy chains in the dynein head where they might regulate enzyme activity (by similarity).
8590	
8591	receptor for extracellular adenine nucleotides such as atp and adp. in pancreatic islets, may mediate some of the effects of extracellular atp on insulin secretion.
8592	
8593	
8594	
8595	
8596	
8597	
8598	involved in transcriptional activation and repression of select genes by chromatin remodelling (alteration of dna- nucleosome topology). required for maximal atpase activity of smarca4/brg1 and for association of the smarca4/brg1 containing remodelling complex baf with chromatin/nuclear matrix. component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. nua4 may also play a direct role in dna repair when recruited to sites of dna damage.
8599	receptor for a c-c type chemokine. binds to mip-1-alpha, mip-1-beta and rantes and subsequently transduces a signal by increasing the intracellular calcium ions level.
8600	
8601	
8602	
8603	receptor for ptpns1. may play a role in membrane transport and/or signal transduction. may prevent premature elimination of red blood cells. may be involved in membrane permeability changes induced following virus infection. may play a role in memory formation. has a role in cell adhesion.
8604	
8605	
8606	
8607	
8608	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
8609	regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. serves as a target for the yopt cysteine peptidase from yersinia pestis, vector of the plague, and yersinia pseudotuberculosis, which causes gastrointestinal disorders.
8610	regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. serves as a target for the yopt cysteine peptidase from yersinia pestis, vector of the plague, and yersinia pseudotuberculosis, which causes gastrointestinal disorders.
8611	tetranectin binds to plasminogen and to isolated kringle 4. may be involved in the packaging of molecules destined for exocytosis.
8612	
8613	
8614	stimulates muscle contractions of specific regions of the gastrointestinal tract. in humans, nmu stimulates contractions of the ileum and urinary bladder.
8615	
8616	could function as a cell-adhesion protein.
8617	receptor for netrin required for axon guidance. mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. axon repulsion in growth cones may be caused by its association with dcc that may trigger signaling for repulsion. also involved in corticospinal tract axon guidances independently of dcc. it also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (by similarity).
8618	
8619	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.
8620	
8621	receptor for neuropeptide y and peptide yy. the rank order of affinity of this receptor for pancreatic polypeptides is npy > [pro-34] pyy, pyy and [leu-31, pro-34] npy > npy (2-36) > [ile-31, gln-34] pp and pyy (3-36) > pp > npy free acid.
8622	this protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
8623	the s.cerevisiae ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-amp.
8624	
8625	
8626	pre-mrna processing factor involved in disassembly of spliceosomes after the release of mature mrna (by similarity).
8627	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
8628	has a glutathione-disulfide oxidoreductase activity in the presence of nadph and glutathione reductase. reduces low molecular weight disulfides and proteins.
8629	part of the ap-3 complex, an adapter-related complex which is not clathrin-associated. the complex is associated with the golgi region as well as more peripheral structures. it facilitates the budding of vesicles from the golgi membrane and may be directly involved in trafficking to lysosomes.
8630	
8631	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
8632	may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. in association with the sfpq-nono heteromer may play a role in nuclear retention of defective rnas.
8633	
8634	
8635	plays a critical role in mhc class ii antigen processing by stabilizing peptide-free class ii alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class ii takes place.
8636	involved in vesicular protein trafficking.
8637	the transhydrogenation between nadh and nadp is coupled to respiration and atp hydrolysis and functions as a proton pump across the membrane.
8638	integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen c-propeptides, fibronectin and e-cadherin. it recognizes the proline-hydroxylated sequence g-f-p-g-e-r in collagen. it is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
8639	
8640	sequence-selective dna-binding protein. could play an important role in gene regulation.
8641	
8642	
8643	
8644	
8645	
8646	
8647	
8648	
8649	probable c to u editing enzyme whose physiological substrate is not yet known. does not display detectable apob mrna editing. has a low intrinsic cytidine deaminase activity.
8650	growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. binds to the vegfr1/flt-1 and vegfr2/kdr receptors, heparan sulfate and heparin. neuropilin-1 binds isoforms vegf-165 and vegf-145.
8651	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
8652	histone h3, along with histone h4, plays a central role in nucleosome formation.
8653	histones h1 are necessary for the condensation of nucleosome chains into higher order structures.
8654	
8655	involved in the presentation of foreign antigens to the immune system.
8656	
8657	
8658	
8659	
8660	
8661	may play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
8662	
8663	may cooperate with cd180 and tlr4 to mediate the innate immune response to bacterial lipopolysaccharide (lps) and cytokine production. important for efficient cd180 cell surface expression (by similarity).
8664	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
8665	
8666	
8667	may function as suppressor of malignant melanoma. it may exert its effects through interactions with the cytoskeleton.
8668	g protein-coupled receptor that probably associates with the patched protein (ptch) to transduce the hedgehog@#$%&s proteins signal. binding of sonic hedgehog (shh) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (smo).
8669	
8670	plays a major role in regulating hemoglobin oxygen affinity as a consequence of controlling 2,3-bpg concentration. can also catalyze the reaction of ec 5.4.2.1 (mutase) and ec 3.1.3.13 (phosphatase), but with a reduced activity.
8671	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
8672	might possibly play a role in rna metabolism.
8673	
8674	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
8675	
8676	
8677	
8678	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
8679	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to sites in the 5@#$%&-flanking sequence of its coding region with various affinities. the consensus sequences of the high and low affinity binding sites are 5@#$%&-taatga[cg]-3@#$%& and 5@#$%&-ctaatttt- 3@#$%&.
8680	
8681	probable core protein of the multisynthetase complex that serves as a template for the assembly of the supramolecular structure. mediates ubiquitination of fubp1 and its degradation by the proteasome.
8682	binds the stem-loop structure of replication-dependent histone pre-mrnas and contributes to efficient 3@#$%& end processing by stabilizing the complex between histone pre-mrna and u7 small nuclear ribonucleoprotein (snrnp). could play an important role in targeting mature histone mrna from the nucleus to the cytoplasm and to the translation machinery. stabilizes mature histone mrna and could be involved in cell-cycle regulation of histone gene expression.
8683	
8684	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
8685	may play a functional role in the cell filament networks.
8686	il-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of b-cells into ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
8687	essential for recycling gmp and indirectly, cgmp.
8688	probable transcription factor, which seems to be involved in the negative regulation of cellular determination and in the differentiation of several lineages including myogenesis, osteogenesis, and neurogenesis. inhibits myogenesis by sequestrating e proteins, inhibiting trans-activation by mef2, and inhibiting dna-binding by myod1 through physical interaction. this interaction probably involves the basic domains of both proteins (by similarity). also represses expression of proinflammatory cytokines such as tnfa and il1b.
8689	probable transcription factor, which seems to be involved in the negative regulation of cellular determination and in the differentiation of several lineages including myogenesis, osteogenesis, and neurogenesis. inhibits myogenesis by sequestrating e proteins, inhibiting trans-activation by mef2, and inhibiting dna-binding by myod1 through physical interaction. this interaction probably involves the basic domains of both proteins (by similarity). also represses expression of proinflammatory cytokines such as tnfa and il1b.
8690	it is able to complement the radiosensitivity defect of an ataxia telangiectasia (at) fibroblast cell line.
8691	it is able to complement the radiosensitivity defect of an ataxia telangiectasia (at) fibroblast cell line.
8692	reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin ix alpha, to bilirubin with the concomitant oxidation of a nadh or nadph cofactor.
8693	
8694	stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. may bind polyunsaturated fatty acids.
8695	stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. may bind polyunsaturated fatty acids.
8696	
8697	
8698	involved in matrix assembly (by similarity).
8699	
8700	probable protease subunit of the cop9 signalosome complex (csn), a complex involved in various cellular and developmental processes. the csn complex is an essential regulator of the ubiquitin (ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the scf-type e3 ligase complexes, leading to decrease the ubl ligase activity of scf-type complexes such as scf, csa or ddb2. the complex is also involved in phosphorylation of p53/tp53, c-jun/jun, ikappabalpha/nfkbia, itpk1 and icsbp, possibly via its association with ck2 and pkd kinases. csn-dependent phosphorylation of tp53 and jun promotes and protects degradation by the ubl system, respectively. in the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. it however has no metalloprotease activity by itself and requires the other subunits of the csn complex. interacts direclty with a large number of proteins that are regulated by the csn complex, confirming a key role in the complex.
8701	has chemotactic activity for neutrophils. may play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. in vitro, the processed forms gro- alpha(4-73), gro-alpha(5-73) and gro-alpha(6-73) show a 30-fold higher chemotactic activity.
8702	may be involved in protein transport from golgi to cell surface. the zdhhc9-golga7 complex is a palmitoyltransferase specific for hras and nras.
8703	auxiliary enzyme of beta-oxidation. it participates in the metabolism of unsaturated fatty enoyl-coa esters having double bonds in both even- and odd-numbered positions. catalyzes the nadp-dependent reduction of 2,4-dienoyl-coa to yield trans-3- enoyl-coa.
8704	
8705	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
8706	
8707	acts as decoy receptor for rankl and thereby neutralizes its function in osteoclastogenesis. inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. bone homeostasis seems to depend on the local rankl/opg ratio. may also play a role in preventing arterial calcification. may act as decoy receptor for trail and protect against apoptosis. trail binding blocks the inhibition of osteoclastogenesis.
8708	
8709	dna-dependent atpase. may modulate chromosome segregation.
8710	
8711	could be a global transcriptional regulator. modifies gene expression by affecting chromatin. may be involved in brain development and facial morphogenesis.
8712	interacts with htr2c and provokes its clustering at the cell surface (by similarity). member of the nmdar signaling complex that may play a role in control of ampar potentiation and synaptic plasticity in excitatory synapses.
8713	dna repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. may be implicated in interstrand dna cross-link repair and in the maintenance of normal chromosome stability.
8714	
8715	
8716	binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
8717	
8718	catalyzes the conversion of pgh2 to pgd2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. involved in a variety of cns functions, such as sedation, nrem sleep and pge2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. it is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
8719	involved in bile acid metabolism. in liver hepatocytes catalyzes the second step in the conjugation of c24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. the major components of bile are cholic acid and chenodeoxycholic acid. in a first step the bile acids are converted to an acyl-coa thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). may catalyze the conjugation of primary or secondary bile acids, or both. the conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. in turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). may also act as an acyl-coa thioesterase that regulates intracellular levels of free fatty acids. in vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-coas to the free fatty acid and coenzyme a (coash), and conjugates glycine to these acyl-coas.
8720	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&.
8721	
8722	required for protein transport from the er to the golgi complex.
8723	
8724	
8725	
8726	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. the produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
8727	
8728	non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via g-protein coupled receptor (gpcr) occupancy by ligands such as bombesin or lysophosphatidic acid, or via ldl receptor occupancy. plays a potential role in oncogenic transformations resulting in increased kinase activity.
8729	
8730	receptor for interleukin-12. this subunit is the signaling component coupling to the jak2/stat4 pathway. promotes the proliferation of t-cells as well as nk cells. induces the promotion of t-cells towards the th1 phenotype by strongly enhancing ifn-gamma production.
8731	
8732	responsible for cleaving the alpha-chains of c4b and c3b in the presence of the cofactors c4-binding protein and factor h respectively.
8733	
8734	
8735	
8736	plays a role in transcriptional coactivation.
8737	
8738	
8739	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
8740	
8741	
8742	
8743	
8744	catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. has little activity towards prostaglandins a1 and e1.
8745	
8746	provides cdp-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (ptdins), phosphatidylglycerol, and cardiolipin. overexpression may amplify cellular signaling responses from cytokines. may also play an important role in the signal transduction mechanism of retina and neural cells.
8747	probable oxidoreductase that acts as a caspase- independent mitochondrial effector of apoptotic cell death. extramitochondrial aif induces nuclear chromatin condensation and large scale dna fragmentation (in vitro).
8748	involved in axon growth. plays an essential role in neurite extension of cerebellar granule cells (by similarity).
8749	may be involved in several stages of intracellular trafficking.
8750	
8751	may serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
8752	
8753	involved in intracellular signal transduction mediated by cytokines and growth factors. when associated with stam, it suppresses dna signaling upon stimulation by il-2 and gm-csf. could be a direct effector of pi3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. may concentrate ubiquitinated receptors within clathrin-coated regions. involved in down- regulation of receptor tyrosine kinase via multivesicular body (mvbs) when complexed with stam. this complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. may contribute to the efficient recruitment of smads to the activin receptor complex.
8754	probable zinc protease. may mediate cell-cell or cell- matrix interactions. isoform 2 displays alpha-secretase activity for app.
8755	
8756	binds opioids in the presence of acidic lipids; probably involved in cell contact.
8757	
8758	required for protein transport from the er to the golgi complex.
8759	
8760	implicated in the control of cell growth. component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals.
8761	catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.
8762	required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo. induces the formation of visceral mesoderm and the heart in early embryos. required later in embryogenesis for dorsal closure and patterning of the hindgut. also functions postembryonically as a long-range morphogen during imaginal disk development; is responsible for the progression of the morphogenetic furrow during eye development. patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. ensures the correct architecture of wing epithelial cells. has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. required for viability of larvae. essential for the maintenance and division of germline stem cells in the ovary. signals via the type i receptor tkv, the type ii receptor punt, and in some tissues via the type i receptor sax, in a signaling cascade that leads to activation and repression of target genes.
8763	
8764	
8765	influences outgrowth of olfactory axons and migration of lhrh neurons (by similarity).
8766	
8767	aminopeptidases catalyze the hydrolysis of amino acid residues from the n-terminus of peptide or protein substrates. able to cleave angiotensin iii to generate angiotensin iv, a bioactive peptide of the renin-angiotensin pathway. not able to cleave angiotensin i and angiotensin ii. may play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.
8768	
8769	
8770	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds selectively to g(z)-alpha and is inhibited by phosphorylation and palmitoylation of the g- protein.
8771	anticoagulant plasma protein; it is a cofactor to activated protein c in the degradation of coagulation factors va and viiia. it helps to prevent coagulation and stimulating fibrinolysis.
8772	acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type i immunity (by similarity).
8773	type i collagen is a member of group i collagen (fibrillar forming collagen).
8774	
8775	
8776	
8777	
8778	is part of lamellipodial complex that controls rac- dependent acting remodelling (by similarity).
8779	synthesizes cyclic adp-ribose, a second messenger that elicits calcium release from intracellular stores. may be involved in pre-b-cell growth.
8780	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes, such as ube2l3/ubcm4, and then transfers it to substrates.
8781	
8782	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
8783	
8784	substrate of the antigen receptor-coupled tyrosine kinase. plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. may also be involved in the regulation of gene expression.
8785	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
8786	plays a fundamental role in microtubule-organizing center structure and function.
8787	not known, could be a tyrosine-phosphatase.
8788	activates cdc42, a member of the ras-like family of rho- and rac proteins, by exchanging bound gdp for free gtp. plays a role in regulating the actin cytoskeleton and cell shape.
8789	
8790	probably involved in connections of major cytoskeletal structures to the plasma membrane.
8791	probably involved in connections of major cytoskeletal structures to the plasma membrane.
8792	may be involved in a pathway that regulates neural cell differentiation and proliferation. possible role in neuroectodermal cell-cell interaction.
8793	receptor that may be a component of a cascade required for development of steroidogenic tissues. acts as a dominant negative regulator of transcription mediated by the retinoic acid receptor.
8794	binds to mbp1, prevents mbp1-mediated transcriptional repression and antagonizes mbp1-mediated cell death. may play a role in vesicular transport from endoplasmic reticulum to golgi.
8795	
8796	
8797	
8798	may eliminate potentially toxic dinucleoside polyphosphates during sporulation. most active against diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p6-hexaphosphate (ap6a). can also hydrolyze diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p5-pentaphosphate (ap5a), adenosine 5@#$%&-pentaphosphate, and adenosine 5@#$%&-tetraphosphate are also substrates, but not diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p4-tetraphosphate (ap4a) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. also cleaves a beta-phosphate from the diphosphate groups in pp-insp5 (diphosphoinositol pentakisphosphate) and [pp]2-insp4 (bisdiphosphoinositol tetrakisphosphate).
8799	
8800	
8801	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
8802	not essential for b12 transport; however, it is an auxiliary component of the transport system.
8803	
8804	involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26s proteasome (by similarity).
8805	calcitermin possesses antifungal activity against c.albicans and is also active against e.coli and p.aeruginosa but not l.monocytogenes and s.aureus.
8806	cross-linked envelope protein of keratinocytes. it is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. all that results in the formation of an insoluble envelope beneath the plasma membrane.
8807	
8808	
8809	calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. receptor propably implicated in the regulation of exocytosis (by similarity).
8810	
8811	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
8812	
8813	involved in dna repair and mitotic recombination. functions in the recombinational dna repair (rad52) pathway. dissociates rad51 from nucleoprotein filaments formed on dsdna. could be involved in the turnover of rad51 protein-dsdna filaments (by similarity). may play also an essential role in telomere length maintenance and telomere capping in mammalian cells.
8814	
8815	
8816	
8817	ligand for cd2. might facilitate interaction between activated lymphocytes. probably involved in regulating t-cell activation.
8818	moderately selective excitatory receptor for orexin-a and, with a lower affinity, for orexin-b neuropeptide. seems to be exclusively coupled to the g(q) subclass of heteromeric g proteins, which activates the phospholipase c mediated signaling cascade (by similarity).
8819	
8820	may be involved in ribosome biogenesis as its disruption leads to increased sensitivity to the antibiotic paromomycin.
8821	activates the metallothionein i promoter. binds to the metal responsive element (mre).
8822	may be involved in transcriptional regulation.
8823	may be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
8824	
8825	adapter protein involved in neuronal nitric-oxide (no) synthesis regulation via its association with nnos/nos1. the complex formed with nos1 and synapsins is necessary for specific no and synapsin functions at a presynaptic level. mediates an indirect interaction between nos1 and rasd1 leading to enhance the ability of nos1 to activate rasd1. competes with dlg4 for interaction with nos1, possibly affecting nos1 activity by regulating the interaction between nos1 and dlg4 (by similarity).
8826	required for protein transport from the er to the golgi complex.
8827	could play a role in neuronal development.
8828	
8829	binds unprenylated rab proteins, presents it to the catalytic rab ggtase dimer, and remains bound to it after the geranylgeranyl transfer reaction. the component a is thought to be regenerated by transferring its prenylated rab back to the donor membrane. less effective than rep-1 in supporting prenylation of rab3 family.
8830	
8831	
8832	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. combines rna-binding and ppiase activities. may be involved in muscle- and brain-specific processes.
8833	may be involved in growth regulation in hematopoietic cells.
8834	
8835	not known.
8836	
8837	rna-binding protein. required for internal initiation of translation of human rhinovirus rna. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain.
8838	potential oncogene and regulator of latent hiv.
8839	
8840	plays a role in neurogenesis and neuronal migration (by similarity). necessary for correct formation of mitotic spindles and chromosome separation during mitosis. necessary for cytokinesis and cell proliferation.
8841	
8842	
8843	collagen type iv is specific for basement membranes. vital for embryonic development.
8844	
8845	acts as positive regulator of androgen receptor- dependent transcription. may function as redox-sensitive chaperone and as sensor for oxidative stress. prevents aggregation of snca. protects neurons against oxidative stress and cell death. plays a role in fertilization. has no proteolytic activity. has weak transforming activity.
8846	
8847	
8848	
8849	
8850	
8851	
8852	
8853	precursors of the cornified envelope of the stratum corneum.
8854	
8855	promotes the exchange of gsp1/gsp2-bound gdp by gtp. involved in yeast pheromone response pathway and in mrna metabolism. probably involved in the control of nuclear organization.
8856	promotes the exchange of gsp1/gsp2-bound gdp by gtp. involved in yeast pheromone response pathway and in mrna metabolism. probably involved in the control of nuclear organization.
8857	catalyzes the production of gaba.
8858	
8859	
8860	
8861	
8862	
8863	transcriptional activator which binds to the enhancer of the t-cell receptor alpha and delta genes. binds to the consensus sequence 5@#$%&-agatag-3@#$%&.
8864	
8865	binds to the transactivation domain of the adenovirus type 5 e1a 32 kda protein (289r) and inhibits its transactivating activity. may act as tumor suppressor through suppression of adenovirus replication.
8866	
8867	
8868	may play a role in vesicular protein sorting, similar to the yeast retromer proteins.
8869	
8870	forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. the channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mv. the open state has a weak anion selectivity whereas the closed state is cation- selective.
8871	may regulate vesicle function in the growth cone (by similarity).
8872	delivers retinol from the liver stores to the peripheral tissues. in plasma, the rbp-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
8873	
8874	gtpase activator for the rho-type gtpases by converting them to an inactive gdp-bound state (by similarity).
8875	part of the proton channel of v-atpases (by similarity).
8876	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
8877	
8878	
8879	may be a mediator of metastasis suppression in breast carcinoma (by similarity).
8880	may regulate the disassembly of focal adhesions. may localize receptor-like tyrosine phosphatases type 2a at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
8881	
8882	
8883	
8884	
8885	binds to the fc region of immunoglobulins epsilon. high affinity receptor. responsible for initiating the allergic response. binding of allergen to receptor-bound ige leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. the same receptor also induces the secretion of important lymphokines.
8886	
8887	
8888	involved in normal and neoplastic cell growth.
8889	transcriptional activator involved in t-cell lymphocyte differentiation. necessary for the survival of cd4(+) cd8(+) immature thymocytes. isoforms lacking the n-terminal ctnnb1 binding domain cannot fulfill this role. binds to the t- lymphocyte-specific enhancer element (5@#$%&-wwcaaag-3@#$%&) found in the promoter of the cd3e gene. may also act as feedback transcriptional repressor of ctnnb1 and tcf7l2 target genes. tle1, tle2, tle3 and tle4 repress transactivation mediated by tcf7 and ctnnb1.
8890	regulator of vesicular trafficking process. required for the sorting of endocytic (egf receptors) cargos. also involved in exocytic cargos of viral proteins of hiv-1 virus. in case of infection by hiv-1 virus, it is recruited to and functions at sites of viral gag assembly and budding. may be involved in cell growth and differentiation. acts as a negative growth regulator.
8891	
8892	
8893	could be involved in the hypothalamic regulation of body weight.
8894	
8895	may function as a regulatory atpase and be related to secretion/protein trafficking process.
8896	the activated kinase acts on a variety of targets. likely to be the gtpase effector that links the rho-related gtpases to the jnk map kinase pathway. activated by cdc42 and rac1. involved in dissolution of stress fibers and reorganization of focal complexes. activity is inhibited in cells undergoing apoptosis, potentially due to binding of cdc2l1 and cdc2l2.
8897	binds specifically to collagen. could be involved as a chaperone in the biosynthetic pathway of collagen.
8898	modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. may play a role in synapse formation during brain development.
8899	
8900	
8901	secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.
8902	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
8903	may be involved in transcriptional regulation.
8904	
8905	
8906	binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
8907	survival-promoting peptide promotes survival of neurons and displays phosphatase activity. it may bind igg.
8908	
8909	receptor that may play a role in the perception of bitterness and is gustducin-linked. may play a role in sensing the chemical composition of the gastrointestinal content. the activity of this receptor may stimulate alpha gustducin, mediate plc-beta-2 activation and lead to the gating of trpm5 (by similarity).
8910	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
8911	regulatory protein, which plays a central role in chromosome stability, in the p53/tp53 pathway, and dna repair. probably acts by blocking the action of key proteins. during the mitosis, it blocks separase/espl1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. at the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of espl1. its function is however not limited to a blocking activity, since it is required to activate espl1. negatively regulates the transcriptional activity and related apoptosis activity of tp53. the negative regulation of tp53 may explain the strong transforming capability of the protein when it is overexpressed. may also play a role in dna repair via its interaction with ku, possibly by connecting dna damage-response pathways with sister chromatid separation.
8912	involved in platelet activation and aggregation. regulates paranodal junction formation. required for gamete fusion. involved in cell adhesion, cell motility and tumor metastasis.
8913	
8914	
8915	
8916	
8917	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
8918	integrin alpha-4/beta-7 (peyer patches-specific homing receptor lpam-1) is expected to play a role in adhesive interactions of leukocytes. it is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced cs-1 region of fibronectin. integrin alpha-4/beta-7 is also a receptor for madcam1 and vcam1. it recognizes the sequence l-d-t in madcam1. integrin alpha-e/beta-7 (hml-1) is a receptor for e- cadherin.
8919	regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. confers calcium sensitivity.
8920	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone (by similarity).
8921	may play a role in apoptosis. may act as a tumor suppressor.
8922	required for normal vision and courtship behavior in drosophila.
8923	involved in regulating eumelanin and phaeomelanin levels.
8924	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (by similarity). probably encodes a dihydropyridine-insensitive current. vital for survival to adulthood.
8925	involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.
8926	
8927	
8928	ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. this enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the c-terminal glycine of either ubiquitin or nedd8.
8929	involved in microtubule organization by the microtubule organizing center, the spindle pole body (spb). probably part of the microtubule attachment site at the spb.
8930	
8931	
8932	regulates chordin (chrd). may play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis.
8933	required maternally for proper expression of other homeotic genes involved in pattern formation, such as ubx.
8934	plays an important role in the de novo pathway of purine nucleotide biosynthesis (by similarity).
8935	
8936	
8937	may be involved in limb tendon and ligament development (by similarity).
8938	mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. may also be required for the transfer of beta-barrel precursors from the tom complex to the sorting and assembly machinery (sam complex) of the outer membrane. acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
8939	
8940	may be involved in several stages of intracellular trafficking.
8941	binds the telomeric double-stranded ttaggg repeat and negatively regulates telomere length. involved in the regulation of the mitotic spindle.
8942	
8943	
8944	mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.
8945	mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.
8946	
8947	transcriptional repressor of the myelin basic protein gene (mbp). binds to the proximal mb1 element 5@#$%&-ttgtcc-3@#$%& of the mbp promoter. its binding to mb1 and function are inhibited by pura (by similarity).
8948	
8949	
8950	
8951	
8952	stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
8953	
8954	plays a fundamental role in microtubule-organizing center structure and function.
8955	mediates tetrahydrobiopterin inhibition of gtp cyclohydrolase i. this inhibition is reversed by l-phenylalanine (by similarity).
8956	seems to specifically modulate the transactivation activity of wt1.
8957	
8958	
8959	unknown, though mvp is required for normal vault structure. vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport.
8960	methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
8961	
8962	
8963	regulatory subunit of the dimeric ube1c-appbp1 e1 enzyme. e1 activates nedd8 by first adenylating its c-terminal glycine residue with atp, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-ube1c thioester and free amp. e1 finally transfers nedd8 to the catalytic cysteine of ube2m. necessary for cell cycle progression through the s-m checkpoint. overexpression of appbp1 causes apoptosis through deregulation of nedd8 conjugation.
8964	
8965	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
8966	may be an ion-channel regulator. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis. involved in adhesive protein-protein and protein-carbohydrate interactions.
8967	can act as repulsive axon guidance cues. may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (by similarity).
8968	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna.
8969	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna.
8970	
8971	
8972	it may be responsible for the synthesis of the sequence neuac-alpha-2,3-gal-beta-1,3-galnac- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. siat4a and siat4b sialylate the same acceptor substrates but exhibit different km values.
8973	acts as a transcriptional repressor. binds to e-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes (by similarity).
8974	
8975	necessary for the splicing of pre-mrna. it is required for formation of the earliest atp-dependent splicing complex and interacts with spliceosomal components bound to both the 5@#$%& and 3@#$%& splice sites during spliceosome assembly. it also is required for atp-dependent interactions of both u1 and u2 snrnps with pre-mrna. interacts with other spliceosomal components, via the rs domains, to form a bridge between the 5@#$%& and 3@#$%& splice site binding components, u1 snrnp and u2af. binds to purine-rich rna sequences, either 5@#$%&-agsagagta-3@#$%& (s=c or g) or 5@#$%&-gttcgagta-3@#$%&. can bind to beta-globin mrna and commit it to the splicing pathway.
8976	
8977	deglycating enzyme which phosphorylates the third carbon of the sugar moiety of ketosamines. may play a role in freeing proteins from ribulosamines or psicosamines.
8978	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex. it has no apparent bacterial homolog and its exact function is unknown.
8979	
8980	
8981	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
8982	
8983	
8984	band 3 is the major integral glycoprotein of the erythrocyte membrane. band 3 has two functional domains. its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin.
8985	
8986	tubulin is the major constituent of microtubules. gamma tubulin is found at microtubule organizing centers (mtoc) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
8987	
8988	
8989	
8990	may complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.
8991	
8992	
8993	rab effector protein acting as linker between gamma- adaptin, rab4a and rab5a. involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. stimulates rabgef1 mediated nucleotide exchange on rab5a.
8994	since they lack a putative transactivation domain, the small mafs behave as transcriptional repressors when they dimerize among themselves. however, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific dna-binding sites. small maf proteins heterodimerize with fos and may act as competitive repressors of the nf-e2 transcription factor. transcription factor, component of erythroid-specific transcription factor nf- e2. activates globin gene expression when associated with nf-e2.
8995	
8996	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii is composed of at least five proteins: the sec23/24 complex, the sec13/31 complex, and the protein sar1. acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex (by similarity).
8997	
8998	
8999	
9000	functions as a component of the nuclear pore complex (npc). npc components, collectively referred to as nucleoporins (nups), can play the role of both npc structural components and of docking or interaction partners for transiently associated nuclear transport factors. involved in nuclear poly(a)+ rna export and npc biogenesis, it is also required for normal nuclear morphology.
9001	mannose-specific lectin. may recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. the lman1-mcfd2 complex forms a specific cargo receptor for the er-to-golgi transport of selected proteins.
9002	may transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid of n-linked oligosaccharides of glycoproteins and glycolipids. it can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.
9003	
9004	
9005	
9006	
9007	may be involved in transcriptional regulation.
9008	probably functions as an alternative splicing regulator. may regulate the mrna splicing of genes such as clk1. may act by regulating members of the clk kinase family (by similarity).
9009	
9010	
9011	
9012	dual specificity kinase that activates the jun kinases mapk8 (jnk1) and mapk9 (jnk2).
9013	
9014	
9015	acts as a factor that allows the dna to undergo a single round of replication per cell cycle. required for dna replication and cell proliferation.
9016	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (by similarity).
9017	may play a role in germ line formation.
9018	major calcium-binding protein of the golgi. may have a role in calcium homeostasis (by similarity).
9019	specific component of the tight junction (tj) plaque, but might not be an exclusively junctional component. may have a house-keeping rule. may be required for pre-mrna polyadenylation.
9020	
9021	communication between transverse-tubules and sarcoplasmic reticulum. contraction of skeletal muscle is triggered by release of calcium ions from sr following depolarization of t-tubules.
9022	
9023	fibrillarin is a component of a nucleolar small nuclear ribonucleoprotein particle thought to participate in the first step in processing preribosomal rna. it is associated with the u3, u8 and u13 small nuclear rnas.
9024	fibrillarin is a component of a nucleolar small nuclear ribonucleoprotein particle thought to participate in the first step in processing preribosomal rna. it is associated with the u3, u8 and u13 small nuclear rnas.
9025	this glycoprotein, produced by the sertoli cells of the testis, causes regression of the muellerian duct. it is also able to inhibit the growth of tumors derived from tissues of muellerian duct origin.
9026	plays a role in membrane ruffling and assembly of clathrin-coated pits at the synapse. mediates rac1-dependent reorganization of actin filaments (by similarity). participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
9027	may play a role in the regulation of ionic transport. binds calcium.
9028	
9029	has a beta1,3-n-acetylglucosaminyltransferase activity for type 2 oligosaccharides.
9030	may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. when overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor (n-linked stearoyl- (c18) ceramide) in a fumonisin b1-independent manner (by similarity).
9031	
9032	
9033	inhibitory regulator of the ras-cyclic amp pathway.
9034	required for membrane traffic to the vacuole.
9035	required for membrane traffic to the vacuole.
9036	binds medium- and long-chain acyl-coa esters with very high affinity and may function as an intracellular carrier of acyl-coa esters. it is also able to displace diazepam from the benzodiazepine (bzd) recognition site located on the gaba type a receptor. it is therefore possible that this protein also acts as a neuropeptide to modulate the action of the gaba receptor.
9037	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. receptor for activin.
9038	this protein binds the camp response element (cre), a sequence present in many viral and cellular promoters. creb stimulates transcription on binding to the cre.
9039	
9040	has a higher affinity for cgmp than for camp.
9041	
9042	
9043	
9044	activator of cdk5/tpkii.
9045	
9046	may play a regulatory role in synaptic vesicle recycling.
9047	receptor for interleukin-1 alpha (il-1a), beta (il-1b), and interleukin-1 receptor antagonist protein (il-1ra).
9048	
9049	together with the ste20-related adaptor-alpha (strad alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of stk11.
9050	
9051	gtpase-activating protein for p21-rac and a phorbol ester receptor. may play an important role in neuronal signal- transduction mechanisms.
9052	component of the escrt-iii complex, which is required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs. the mvb pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. the escrt-iii complex is probably involved in the concentration of mvb cargo. required for sorting/trafficking of egf receptor. in case of infection, the hiv-1 virus takes advantage of the escrt-iii complex for budding and exocytic cargos of viral proteins.
9053	produced by activated macrophages, il-1 stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. il-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
9054	
9055	this protein binds free fatty acids and their coenzyme a derivatives, bilirubin, and some other small molecules in the cytoplasm; it may be involved in intracellular lipid transport.
9056	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation via its interaction with the myocyte enhancer factors such as mef2a, mef2c and mef2d.
9057	
9058	ppiases accelerate the folding of proteins during protein synthesis.
9059	
9060	
9061	
9062	
9063	histones h1 are necessary for the condensation of nucleosome chains into higher order structures.
9064	involved in the activation cascade of caspases responsible for apoptosis execution. at the onset of apoptosis it proteolytically cleaves poly(adp-ribose) polymerase (parp) at a 216-asp-|-gly-217 bond. cleaves and activates sterol regulatory element binding proteins (srebps) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. cleaves and activates caspase-6, -7 and -9. involved in the cleavage of huntingtin.
9065	
9066	collagen type ii is specific for cartilaginous tissues. it is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
9067	
9068	
9069	binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
9070	plays an important role in control of proteasome function. inhibits the hydrolysis of protein and peptide substrates by the 20s proteasome. also inhibits the activation of the proteasome by the proteasome regulatory proteins pa700 and pa28.
9071	required for 60s ribosomal subunit biogenesis.
9072	involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. may play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. low-affinity receptor for agouti (by similarity). has a critical role in normal myelination in the central nervous system (by similarity).
9073	
9074	
9075	involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.
9076	transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+) (by similarity).
9077	might support glycosylation reactions in the golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. hydrolyzes preferentially nucleoside 5@#$%&-diphosphates, nucleoside 5@#$%&-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5@#$%&-monophosphates. the order of activity with different substrates is gdp > idp >> udp = cdp >> adp (by similarity).
9078	
9079	binds activated protein c. enhances protein c activation by the thrombin-thrombomodulin complex; plays a role in the protein c pathway controlling blood coagulation.
9080	makes part of tfiid is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. potentiates transcriptional activation by the af-2s of the retinoic acid, vitamin d3 and thyroid hormone.
9081	overexpression impairs serum-induced cell cycle progression from the g0/g1 to s phase.
9082	
9083	
9084	
9085	
9086	
9087	
9088	probably methylates the guanidino nitrogens of arginyl residues in some proteins. may play a role in transcriptional coactivation.
9089	probable protease. seems to be capable of activating enac.
9090	
9091	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
9092	
9093	may be an important signaling intermediate between tgfb receptors and map3k7/tak1. may play an important role in mammalian embryogenesis.
9094	
9095	binds to the 5@#$%&stem-loop of u4 snrna and may play a role in the late stage of spliceosome assembly. the protein undergoes a conformational change upon rna-binding.
9096	
9097	
9098	
9099	
9100	
9101	
9102	
9103	
9104	arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
9105	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
9106	
9107	
9108	possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane (by similarity).
9109	
9110	has gtpase activity. may mediate the membrane association of sr alpha (by similarity).
9111	
9112	
9113	
9114	
9115	
9116	lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.
9117	required for assembly of the mitotic spindle. interact with spindle microtubules to produce an outwardly directed force acting upon the poles. following spindle assembly, cin8 and kip1 apparently act to oppose a force that draws separated poles back together. this force seems to be mediate by kar3.
9118	
9119	
9120	
9121	
9122	
9123	negatively regulates bone density. antagonizes the ability of certain osteogenic bmps to induce osteoprogenitor differentitation and ossification.
9124	
9125	
9126	component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity.
9127	
9128	
9129	
9130	
9131	
9132	
9133	
9134	
9135	core tafii present in both of the previously described tfiid species which either lack or contain tafii30 (tfiid alpha and tfiid beta respectively).
9136	guanine nucleotide exchange factor that interacts with rhoa, but not with rac or cdc42. activates rhoa to promote cytoskeletal contraction and inhibit neurite outgrowth.
9137	
9138	adapter protein which binds ubiquitin and may regulate the activation of nfkb1 by tnf-alpha, nerve growth factor (ngf) and interleukin-1. may play a role in titin/ttn downstream signaling in muscle cells. may regulate signaling cascades through ubiquitination. may be involved in cell differentiation, apoptosis, immune response and regulation of k(+) channels.
9139	
9140	
9141	
9142	involved in the regulation of homocysteine metabolism. converts betaine and homocysteine to dimethylglycine and methionine, respectively. this reaction is also required for the irreversible oxidation of choline.
9143	signal-recognition-particle assembly, binds directly to 7s rna and mediates binding of the 54 kda subunit of the srp.
9144	
9145	appears to be required for normal postnatal skeletal growth and cartilage homeostasis.
9146	receptor that is activated by both amino acids and extracellular concentration of calcium ions. the activity of this receptor is mediated by a g-protein that activates a phosphatidylinositol-calcium second messenger system. senses changes in the extracellular concentration of calcium ions, suggesting that it may mediate extracellular calcium-sensing responses in osteoblasts. osteocalin, stimulates its activity in presence of calcium. has a lower affinity for calcium than casr. also acts as a receptor for amino acids, with a preference for basic amino acids such as l-lys, l-arg and l-ornithine. its affinity for amino acids suggests that it may act as a regulatory component of the urea cycle.
9147	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
9148	
9149	shows weak transcriptional activatory activity. transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide.
9150	protein tyrosine phosphatase which stimulates progression from g1 into s phase during mitosis. may play a role in the development and maintenance of differentiating epithelial tissues. enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
9151	
9152	
9153	may contribute to the development of sarcomas.
9154	
9155	in response to ifn-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin f2-alpha (pgf), and thus prevent lysis of the corpus luteum and maintain the pregnancy.
9156	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
9157	
9158	
9159	
9160	transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (@#$%&gcat@#$%&) and (@#$%&taat@#$%&), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. positively regulates the genes under the control of corticotropin-releasing hormone (crh) and crh ii promoters (by similarity).
9161	
9162	
9163	
9164	
9165	
9166	
9167	transcriptional activator that binds with high affinity to the t-cell enhancer motif 5@#$%&-aacaaag-3@#$%& motif.
9168	
9169	catalyzes the formation of an hydroxyacyl-coa by addition of water on enoyl-coa. also exhibits 3-hydroxyacyl-coa epimerase and 3-hydroxyacyl-coa dehydrogenase activities. involved in the aerobic and anaerobic degradation of long-chain fatty acids.
9170	type i collagen is a member of group i collagen (fibrillar forming collagen).
9171	
9172	during embryonic development, some isoforms are essential for proper neuronal differentiation and organization. required for cell polarity; maintenance of apicobasal polarity. plays a critical role at septate junctions in cellular growth control during larval development. the presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
9173	calcium-dependent mitochondrial aspartate and glutamate carrier. may have a function in the urea cycle.
9174	
9175	
9176	
9177	
9178	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
9179	
9180	
9181	
9182	
9183	
9184	energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
9185	acts as a positive regulator of apoptosis.
9186	
9187	likely to play role in the modification of cellular properties that underlie long-term plasticity. binds to agar matrix in a calcium-dependent manner (by similarity).
9188	
9189	binds the poly(a) tail of mrna. may be involved in cytoplasmic regulatory processes of mrna metabolism. its function in translational initiation regulation can either be enhanced by paip1 or repressed by paip2. can probably bind to cytoplasmic rna sequences other than poly(a) in vivo. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain.
9190	involved in dna repair and mitotic recombination. may play an active role in recombination processes in concert with other members of the rad52 epistasis group.
9191	
9192	probable transcriptional activator in the premeiotic germ cells. it binds to the sequences 5@#$%&-aacaat-@#$%&3 or 5@#$%&-aacaaag- 3@#$%& (by similarity).
9193	receptor for interferon gamma. two receptors bind one interferon gamma dimer.
9194	probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation during skeletal muscle atrophy.
9195	
9196	converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single arg-val bond in plasminogen. by controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. play a direct role in facilitating neuronal migration.
9197	
9198	immediate-early protein likely to play a role in cell growth regulation (by similarity).
9199	promotes guanine-nucleotide exchange on arf1 and arf3. promotes the activation of arf1/arf3 through replacement of gdp with gtp.
9200	
9201	
9202	induces bone formation in conjunction with tgf-beta-1 or tgf-beta-2.
9203	
9204	negatively regulates matrix metalloproteinase-9 (mmp-9) by suppressing mmp-9 secretion and by direct inhibition of its enzymatic activity. reck down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. appears to also regulate mmp-2 and mt1-mmp, which are involved in cancer progression.
9205	resistance to tetracycline by an active tetracycline efflux. this is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. this protein functions as a metal-tetracycline/h(+) antiporter.
9206	transcriptional corepressor that binds to a number of transcription factors. inhibits the transcriptional activation mediated by pax5, and by ctnnb1 and tcf family members in wnt signaling. the effects of full-length tle family members may be modulated by association with dominant-negative aes (by similarity).
9207	binds free retinal and cellular retinol-binding protein- bound retinal. can convert/oxidize retinaldehyde to retinoic acid (by similarity).
9208	may be the negative regulator of ets1 and may inhibit nuclear factor-kappab activation.
9209	
9210	specific growth arrest protein involved in growth suppression. blocks entry to s phase. prevents cycling of normal and transformed cells.
9211	
9212	jana and janb regulate somatic sex differentiation.
9213	receptor for interleukin-11. the receptor systems for il6, lif, osm, cntf, il11 and ct1 can utilize il6st for initiating signal transmission. the il11/il11ra/il6st complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.
9214	
9215	may play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.
9216	
9217	
9218	
9219	protein phosphatase (pp1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. involved in regulation of ionic conductances and long-term synaptic plasticity.
9220	splits dipeptides with a prolyl or hydroxyprolyl residue in the c-terminal position. plays an important role in collagen metabolism because the high level of iminoacids in collagen.
9221	catalyzes the covalent attachment of ubiquitin to other proteins. in association with the e3 enzyme bre1 and lge1, it plays a role in transcription regulation by catalyzing the monoubiquitination of lys-123 of histone h2b leading to the trimethylation of histone h3 lys-4 by compass, the localization of the paf1 complex to the chromatin and the silencing of telomeric- associated genes. in association with the e3 enzyme rad18, it catalyzes the monoubiquitination of pol30 lys-164, involved in postreplication repair of uv-damaged dna. the ubc2-rad18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine. in association with the e3 enzyme ubr1, is involved in n-end rule-dependent protein degradation. also involved in sporulation.
9222	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
9223	may be involved in redox reactions associated with the formation of disulfide bonds. may contribute to the quality control of protein folding in the endoplasmic reticulum (by similarity).
9224	
9225	
9226	the crk-i and crk-ii forms differ in their biological activities. crk-ii has less transforming activity than crk-i. crk- ii mediates attachment-induced mapk8 activation, membrane ruffling and cell motility in a rac-dependent manner. involved in phagocytosis of apoptotic cells and cell motility via its interaction with dock1 and dock4.
9227	specifically recognizes the xenobiotic response element (xre).
9228	binds to f-actin in a calcium-independent manner. has no direct effect on actin depolymerization.
9229	
9230	seems to be involved in p53/tp53 activation and p53/tp53-dependent apoptotic pathways, probably by enhancing acetylation of p53/tp53. component of a msina-like corepressor complex, which probably is involved in deacetylation of nucleosomal histones. ing1l activity seems to be modulated by binding to phosphoinositides (ptdinsps).
9231	promotes guanine-nucleotide exchange on arf1 and arf5. promotes the activation of arf through replacement of gdp with gtp.
9232	may play a role in chondrocyte differentiation and may also influence cervix development. functions as a repressor with the rat prolactin promoter in vivo.
9233	
9234	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
9235	
9236	does not have a carbonic anhydrase catalytic activity.
9237	catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. mao-a preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-ht), norepinephrine and epinephrine.
9238	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
9239	acts as guanine nucleotide exchange factor (gef) for rhoa gtpase. may be involved in activation of the sapk/jnk pathway (by similarity).
9240	
9241	
9242	muscle contraction.
9243	thought to stabilize the calcium channel in an inactivated (closed) state.
9244	
9245	
9246	neural cell adhesion molecule.
9247	
9248	
9249	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
9250	
9251	
9252	appears to be involved in the development of the central nervous system specifying regional identities in the development of the forebrain and spinal cord. can recognize, bind and transactivate the np (nearly palindromic) target sequence present in the engrailed gene regulatory region.
9253	
9254	
9255	
9256	component of the cop9 signalosome complex (csn), a complex involved in various cellular and developmental processes. the csn complex is an essential regulator of the ubiquitin (ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of scf-type e3 ligase complexes, leading to decrease the ubl ligase activity of scf-type complexes such as scf, csa or ddb2. the complex is also involved in phosphorylation of p53/tp53, c-jun/jun, ikappabalpha/nfkbia, itpk1 and icsbp, possibly via its association with ck2 and pkd kinases. csn-dependent phosphorylation of tp53 and jun promotes and protects degradation by the ubl system, respectively. has some glucocorticoid receptor- responsive activity.
9257	
9258	component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. three proteases; ndl, gd and snk process easter to create active easter. active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the tl receptor in the ventral region of the embryo. promotes heterophilic cellular adhesion. spz c-106 in the hemolymph controls expression of the antifungal peptide drosomycin (drs) by acting as a ligand of tl and inducing an intracellular signaling pathway.
9259	could act as a modulator of transcription.
9260	
9261	acts as an actin bundling protein. may play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
9262	
9263	
9264	
9265	
9266	may act in the sexual differentiation pathway (by similarity).
9267	nmda receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine. this protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. it mediates neuronal functions in glutamate neurotransmission. is involved in the cell surface targeting of nmda receptors (by similarity).
9268	
9269	
9270	type i collagen is a member of group i collagen (fibrillar forming collagen).
9271	
9272	
9273	involved in cytokinesis (potential).
9274	aminopeptidase with broad substrate specificity to several peptides. involved in proteolytic events essential for cell growth and viability. may act as regulator of neuropeptide activity (by similarity).
9275	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1b gives rise to n-type calcium currents. n-type calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group and are blocked by omega-conotoxin-gvia (omega-ctx-gvia) and by omega-agatoxin- iiia (omega-aga-iiia). they are however insensitive to dihydropyridines (dhp), and omega-agatoxin-iva (omega-aga-iva). calcium channels containing alpha-1b subunit may play a role in directed migration of immature neurons.
9276	
9277	catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. mao-b preferentially degrades benzylamine and phenylethylamine.
9278	acts as a rac1 guanine nucleotide exchange factor (gef).
9279	
9280	may be involved in several stages of intracellular trafficking (by similarity).
9281	
9282	
9283	
9284	
9285	
9286	this is the major myelin protein from the central nervous system. it plays an important role in the formation or maintenance of the multilamellar structure of myelin.
9287	binds as a monomer with high affinity to interleukin 13 (il13), but not to il4.
9288	
9289	
9290	
9291	
9292	catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in rab proteins with an -xxcc, -xcxc and -ccxx c-terminal, such as rab1a, rab3a and rab5a respectively.
9293	involved in the retrieval of endoplasmic reticulum membrane proteins from the early golgi compartment (by similarity).
9294	
9295	plays a role as a transcriptional repressor during development. may play a role in the control of cell survival. overexpression of rere recruits bax to the nucleus particularly to pod and triggers caspase-3 activation, leading to cell death.
9296	receptor for netrin required for axon guidance. mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. its association with unc5 proteins may trigger signaling for axon repulsion. it also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. implicated as a tumor suppressor gene.
9297	interacts strongly with cdk6, weakly with cdk4. inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein rb.
9298	orphan receptor.
9299	e3 ubiquitin ligase protein that mediates monoubiquitination of lys-119 of histone h2a, thereby playing a central role in histone code and gene regulation. h2a lys-119 ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in x chromosome inactivation of female mammals. may be involved in the initiation of both imprinted and random x inactivation. essential component of the polycomb group (pcg) multiprotein prc1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including hox genes, throughout development. pcg prc1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. acts as the main e3 ubiquitin ligase on histone h2a of the prc1 complex, while ring1 and pcgf4/bmi1 may rather act as a modulator of rnf2/ring2 activity.
9300	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna.
9301	
9302	recognizes and binds the palindromic sequence 5@#$%&- ttggcnnnnngccaa-3@#$%& present in viral and cellular promoters and in the origin of replication of adenovirus type 2. these proteins are individually capable of activating transcription and replication.
9303	binds gtp, gdp and gmp. hydrolyzes gtp very efficiently; gdp rather than gmp is the major reaction product.
9304	binds to the sequence 5@#$%&-aacaat-3@#$%& (by similarity).
9305	receptor for the fc region of complexed or aggregated immunoglobulins gamma. low affinity receptor. involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by b- cells. binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on b-cells (bcr), t-cells (tcr) or via another fc receptor. isoform iib1 fails to mediate endocytosis or phagocytosis. isoform iib2 does not trigger phagocytosis.
9306	may contribute to the transcriptional control of cell growth and differentiation. antagonizes transcriptional activation and cellular transformation by the adenovirus e1a protein. the transcriptional control activity of cell growth requires interaction with igf2r.
9307	
9308	
9309	may play a role in carrying and orienting carbohydrate, as well as having a more specific role.
9310	
9311	plays an important role in the de novo pathway of purine nucleotide biosynthesis.
9312	
9313	
9314	
9315	
9316	
9317	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
9318	
9319	catalyzes the covalent attachment of ubiquitin to other proteins (by similarity).
9320	the association of the dr1/drap1 heterodimer with tbp results in a functional repression of both activated and basal transcription of class ii genes. this interaction precludes the formation of a transcription-competent complex by inhibiting the association of tfiia and/or tfiib with tbp. can bind to dna on its own.
9321	
9322	
9323	
9324	
9325	
9326	
9327	
9328	may control the transcriptional activity of c-myc. stimulates the activation of e box-dependent transcription by c- myc.
9329	
9330	part of the complex catalyzing the transfer of n- acetylglucosamine from udp-n-acetylglucosamine to phosphatidylinositol, the first step of gpi biosynthesis.
9331	may have a special functional role during embryogenesis and in adult hematopoietic cells. binds to ubiquitin.
9332	
9333	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
9334	orphan receptor; possibly for a chemokine.
9335	microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (by similarity).
9336	
9337	catalyzes the first step in the removal of the two c-4 methyl groups of 4,4-dimethylzymosterol.
9338	
9339	
9340	potential iron transporter (by similarity).
9341	may have a role in potentiating calcium ion-dependent signaling.
9342	
9343	
9344	
9345	
9346	may neutralize hydrolytic enzymes.
9347	
9348	may be involved in transcriptional regulation.
9349	may donate electrons to ubiquinone.
9350	involved in amino acid efflux from the vacuole to the cytoplasm. capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine.
9351	
9352	
9353	apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated fas (cd95) or tnfr-1 receptors. the resulting aggregate called the death-inducing signaling complex (disc) performs caspase-8 proteolytic activation. active caspase-8 initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
9354	
9355	inhibits generation of il-1beta by interacting with caspase-1 and preventing its association with rip2.
9356	actin cross-linking/gelling protein (by similarity). involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
9357	actin cross-linking/gelling protein (by similarity). involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
9358	
9359	
9360	
9361	component of pre-mrna cleavage complex ii and of the trna splicing endonuclease complex.
9362	associates with pyk2 in lymphoid cells. may regulate signaling at sites of adhesion.
9363	involved in normal and neoplastic cell growth.
9364	
9365	major acute phase reactant. apolipoprotein of the hdl complex.
9366	
9367	
9368	provides the precursors necessary for dna synthesis. catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
9369	glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to g3p and the corresponding alcohols.
9370	
9371	binds specifically to gtp-rho. may serve as a target for rho. it has no enzymatic activity. it may interact with some cytoskeletal component upon rho binding or relay a rho signal to other molecules.
9372	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
9373	
9374	catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
9375	probably involved in synaptic functions in the cns.
9376	
9377	
9378	
9379	component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. nua4 may also play a direct role in dna repair when recruited to sites of dna damage.
9380	binds to hiv-1 tar rna located in the long terminal repeat (ltr). acts synergistic with viral tat protein in hiv-1 expression activation. binds preferentially tar and other double- stranded rnas with g+c-rich characteristics.
9381	this protein is one of the chains of the nonenzymatic membrane component (f0) of mitochondrial atpase.
9382	
9383	
9384	may have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.
9385	component of the elastin-associated microfibrils.
9386	
9387	
9388	class-iv neuronal intermediate filament that is able to self-assemble. it is involved in the morphogenesis of neurons. it may form an independent structural network without the involvement of other neurofilaments or it may cooperate with nf-l to form the filamentous backbone to which nf-m and nf-h attach to form the cross-bridges (by similarity).
9389	
9390	involved in 40s ribosomal subunit biogenesis. it seems to play a role a methylation reaction in pre-rrna processing (by similarity).
9391	
9392	required for the establishment or function of the nervous system.
9393	plays a role in pre-mrna alternative splicing by regulating spliceosome assembly.
9394	involved in muscle differentiation (myogenic factor). induces fibroblasts to differentiate into myoblasts. probable sequence specific dna-binding protein.
9395	involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (nk) cells, and platelets.
9396	
9397	binds specifically to the dna sequence 5@#$%&-aacaat-3@#$%&. activates transcription of col2a1 and agc1 in vitro.
9398	
9399	may act as a tumor suppressor.
9400	catalyzes the hydrolysis of atp coupled with the exchange of h(+) and k(+) ions across the plasma membrane. responsible for potassium absorption in various tissues.
9401	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
9402	
9403	
9404	component of the anaphase promoting complex/cyclosome (apc/c), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the g1 phase of the cell cycle.
9405	prevents the aggregation of denatured proteins in cells under severe stress, on which the atp levels decrease markedly. inhibits hspa8/hsc70 atpase and chaperone activities (by similarity).
9406	
9407	
9408	required for cytoplasm to vacuole transport (cvt) vesicles and autophagosomes completion. necessary for the binding of atg18 to atg9. involved in correct atg9 trafficking through the pre-autophagosomal structure and in peroxisome degradation.
9409	inhibitor of serine proteases. the primary target is elastase, but also has a moderate affinity for plasmin and thrombin.
9410	
9411	the smn complex plays an essential role in spliceosomal snrnp assembly in the cytoplasm and is required for pre-mrna splicing in the nucleus.
9412	lipid transport protein in adipocytes. binds both long chain fatty acid and retinoic acid.
9413	
9414	may be a component of one of the vesicle trafficking pathways. may interact functionally with ras2 protein.
9415	
9416	
9417	
9418	
9419	potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. key regulator of adherens junction integrity and differentiation that may be involved in cdh1-mediated adhesion and signaling in epithelial cells.
9420	acts on epoxides (alkene oxides, oxiranes) and arene oxides. plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. also determines steady-state levels of physiological mediators. has low phosphatase activity.
9421	
9422	
9423	implicated in the control of cell fate decisions during development.
9424	involved in embryogenesis and cell differentiation.
9425	ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. covalent attachment to its substrates requires prior activation by the e1 complex ube1c- appbp1 and linkage to the e2 enzyme ube2m. attachment of nedd8 to cullins activates their associated e3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
9426	acts as a transcriptional repressor. may be involved in dna damage-inducible cell cycle arrests (checkpoints).
9427	
9428	cpsf plays a key role in pre-mrna 3@#$%&-end formation, recognizing the aauaaa signal sequence and interacting with poly(a)polymerase and other factors to bring about cleavage and poly(a) addition (by similarity).
9429	this enzyme is involved in nucleotide metabolism: it produces dump, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dutp so that uracil cannot be incorporated into dna.
9430	
9431	
9432	stimulates smooth muscle contraction in a manner similar to that of bombesin.
9433	hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-coa thioesters. it is an important enzyme in hdl metabolism. hepatic lipase binds heparin.
9434	
9435	regulation of the apolipoprotein a-i gene transcription. binds to dna site a.
9436	
9437	broad specificity aminopeptidase. plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. may play a critical role in the pathogenesis of cholesterol gallstone disease. may be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the cns. found to cleave antigen peptides bound to major histocompatibility complex class ii molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. is also implicated as a regulator of il-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. also serves as a receptor for human coronavirus serogroup 1 (hcov-229e) in a species-specific manner. mediates as well human cytomegalovirus (hcmv) infection.
9438	
9439	may have a role in checkpoint signaling during mitosis (by similarity). enhances tp53-mediated transcriptional activation. binds to sites of dna damage. plays a role in the response to dna damage.
9440	
9441	may participate in a common dna damage response pathway associated with the activation of homologous recombination and double-strand break repair. binds to single and double stranded dna and exhibits dna-dependent atpase activity. underwinds duplex dna and forms helical nucleoprotein filaments.
9442	
9443	
9444	
9445	regulates the differentiation and proliferation of normal cells through the regulation of cell death.
9446	unknown, though mvp is required for normal vault structure. vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport.
9447	
9448	
9449	
9450	has both an apurinic and/or apyrimidinic endonuclease activity and a dna n-glycosylase activity. incises damaged dna at cytosines, thymines and guanines. acts on a damaged strand, 5@#$%& from the damaged site. required for the repair of both oxidative dna damage and spontaneous mutagenic lesions.
9451	
9452	
9453	
9454	
9455	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
9456	possesses a trypsin-like cleavage specificity (by similarity).
9457	
9458	part of the nucleoporin complex; required for correct nuclear pore assembly.
9459	probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. may act as a tumor suppressor.
9460	
9461	may be involved in transcriptional regulation.
9462	component of the swr1 complex which mediates the atp- dependent exchange of histone h2a for the h2a variant hzt1 leading to transcriptional regulation of selected genes by chromatin remodeling. involved in chromosome stability.
9463	reversible hydration of carbon dioxide.
9464	may be involved in transcriptional regulation.
9465	involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. plays a role in the assembly of the exocyst.
9466	involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. plays a role in the assembly of the exocyst.
9467	plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. agonist-dependent changes in lasp1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other f-actin-rich secretory epithelial cell types (by similarity).
9468	involved in the transduction of mitogenic signals from the cell membrane to the nucleus.
9469	essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. gp30 is a potential ligand for this receptor. not activated by egf, tgf- alpha and amphiregulin.
9470	plays a role in the formation of clathrin-coated invaginations and endocytosis.
9471	may play a role in antiviral host defense. protects against infection by a neurovirulent strain of sindbis virus. may play a role in autophagy.
9472	chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. augments monocyte anti-tumor activity. has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
9473	probable sugar transporter (by similarity).
9474	
9475	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
9476	
9477	circadian regulator that may act as a transcription factor. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition. seems to be the pacemaker component which responds to light and mediates photic entrainment. in the suprachiasmatic nucleus (scn), it behaves like a day-type oscillator, with maximum expression during the light period. oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. there is a 4 hour time delay between per1 and per2 oscillations. the expression rhythms appear to originate from retina. negatively regulates clock-arntl/bmal1-induced transactivation (by similarity).
9478	hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. it is important for proliferation during certain stages of b-cell maturation.
9479	
9480	
9481	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i (by similarity).
9482	
9483	protein phosphatase that specifically mediates dephosphorylation of ser-473 of akt1, a protein that regulate the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. dephosphorylation of ser- 473 of akt1 triggers apoptosis and suppression of tumor growth. may act as a negative regulator of k-ras signaling in the membrane rafts.
9484	laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha- 6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-fak and p80, (3) differentiation of keratinocytes.
9485	
9486	plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
9487	
9488	
9489	forms a complex with a krab-domain transcription factor and increases the efficiency of krab-mediated repression. silences transcription through an interaction with hp1 proteins. acts as a corepressor of transcription for the krab zinc finger proteins and as a moderator of the repression activity. may play a role as a coactivator for cebpb and nr3c1 in the transcriptional activation of the alpha-1-acid glycoprotein gene (by similarity).
9490	interacts strongly with cdk4 and cdk6.
9491	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
9492	interacts with hsp70 and can stimulate its atpase activity. stimulates the association between hsc70 and hip.
9493	catalyzes the oxidative decarboxylation of glutaryl-coa to crotonyl-coa and co(2) in the degradative pathway of l-lysine, l-hydroxylysine, and l-tryptophan metabolism. it uses electron transfer flavoprotein as its electron acceptor. the short isoform is inactive.
9494	
9495	orphan receptor. binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5@#$%&-aggtca-3@#$%& and 4-nt spacing (dr-4).
9496	may be involved in processing of pneumocyte surfactant precursors.
9497	catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. may also function as a transporter of branched chain alpha-keto acids.
9498	suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. regulates cell death by controlling the mitochondrial membrane permeability. appears to function in a feedback loop system with caspases. inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1).
9499	
9500	catalyzes the transfer of sulfate to position 4 of non- reducing n-acetylgalactosamine (galnac) residues in both n-glycans and o-glycans. required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. only active against terminal galnacbeta1,galnacbeta. not active toward chondroitin.
9501	functions as an e3-type small ubiquitin-like modifier (sumo) ligase, stabilizing the interaction between ube2i and the substrate, and as a sumo-tethering factor. plays a crucial role as a transcriptional coregulation in various cellular pathways, including the stat pathway, the p53 pathway, the wnt pathway and the steroid hormone signaling pathway. involved in gene silencing.
9502	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
9503	
9504	subunit of the splicing factor sf3a required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex.
9505	supports the survival of sympathetic neurons in culture. may regulate the development and maintenance of the cns. might control the size of non-neuronal cell population such as haemopoietic cells.
9506	
9507	
9508	
9509	
9510	transcription factor.
9511	
9512	required maternally for proper expression of other homeotic genes involved in pattern formation, such as ubx.
9513	
9514	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
9515	
9516	part of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends. may function with rpp38 to coordinate the nucleolar targeting and/or assembly of rnase p.
9517	binds dna. interacts with chromatin via matrix attachment regions (mars). likely to participate in nuclear architecture by connecting chromatin with the nuclear matrix and potentially with the nuclear envelope (by similarity).
9518	component of the 39s subunit of mitochondrial ribosome.
9519	
9520	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the p170 subunit of eif3.
9521	may be involved in the control of a single round of dna replication during s phase. binds to chromatin during g1 and detach from it during s phase as if it licenses the chromatin to replicate.
9522	by its binding to cytohesin-1 (pscd1), it modifies activation of arfs by pscd1 and its precise function may be to sequester pscd1 in the cytoplasm.
9523	may function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment (by similarity).
9524	interacts with mapk kinases and regulates activation of map kinases. does not display kinase activity (by similarity).
9525	
9526	implicated in neuroendocrine secretory processes. may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. seems to lack intrinsic enzyme activity. may play a role in the regulation of secretory granules via its interaction with sntb2.
9527	
9528	
9529	may act as a mediator of stress-activated signals.
9530	
9531	serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as tnf-alpha. appears to act upstream of the jun n-terminal pathway.
9532	rna-binding protein. possesses nucleolytic activity against cytotoxic lymphocyte target cells. may be involved in apoptosis.
9533	
9534	
9535	appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor (by similarity). activates eif2ak2 in absence of double stranded rna (dsrna).
9536	ga733 tumor-associated antigen gene family may function as growth factor receptors.
9537	
9538	was first identified based on its probable role in the regulation of pituitary gene transcription. binds to the prolactin gene (prl) promoter and seems to activate transcription. guanine nucleotide exchange factor that activates sara2. required for the formation of copii transport vesicles from the er (by similarity).
9539	
9540	transporter for alanine, serine, cysteine, and threonine. exhibits sodium dependence.
9541	involved in cytokinesis (potential). can bind to gtp and exert gtpase activity.
9542	acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin g. may prevent elastase-mediated damage to oral and possibly other mucosal tissues.
9543	
9544	required for 60s ribosomal subunit biogenesis.
9545	
9546	
9547	thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. this complex is responsible for the conversion of protein c to the activated protein c (protein ca). once evolved, protein ca scissions the activated cofactors of the coagulation mechanism, factor va and factor viiia, and thereby reduces the amount of thrombin generated.
9548	
9549	probably involved in the control of the cell cycle. interacts with cyclins a, b3, d, or e. activity of cdk2 is maximal during s phase and g2.
9550	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
9551	
9552	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
9553	
9554	inhibits gtp exchange on ran. forms a ran-gtp-ranbp1 trimeric complex. increase gtp hydrolysis induced by the ran gtpase activating protein rangap1. may act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
9555	the expression of mif at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. also acts as a phenylpyruvate tautomerase.
9556	might normally function as a repressor. ews-fusion- proteins (efps) may play a role in the tumorigenic process. they may disturb gene expression by mimicking, or interfering with the normal function of ctd-polii within the transcription initiation complex. they may also contribute to an aberrant activation of the fusion protein target genes.
9557	
9558	glycosyltransferase which participates in glycosylation of alpha-dystroglycan. may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. may be involved in the addition of a repeated disaccharide unit.
9559	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the subunit p170 of eif- 3.
9560	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the subunit p170 of eif- 3.
9561	transcription factor that binds to and transactivates the tshb promoter. binds to a minimal dna-binding sequence 5@#$%&- [tc][ag][ag]tta[tc][ag]-3@#$%&.
9562	
9563	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
9564	catalyzes the reversible phosphorolysis of thymidine. the produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
9565	
9566	the soluble isoform 2 binds vegf-165 and appears to inhibit its binding to cells. it may also induce apoptosis by sequestering vegf-165. may bind as well various members of the semaphorin family. its expression has an averse effect on blood vessel number and integrity.
9567	
9568	
9569	this coatomer complex protein, essential for golgi budding and vesicular trafficking, is a selective binding protein (rack) for protein kinase c, epsilon type. it binds to golgi membranes in a gtp-dependent manner (by similarity).
9570	
9571	may mediate accelerated atp-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
9572	
9573	exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in trnas with gu(n) anticodons (trna-asp, -asn, -his and -tyr). after this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (by similarity).
9574	inhibitory regulator of the ras-cyclic amp pathway. binds inositol tetrakisphosphate (ip4).
9575	arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
9576	hydrolyzes a variety of proteins.
9577	induces apoptosis (by similarity).
9578	intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate.
9579	
9580	involved in the base excision repair (ber) pathway, by catalyzing the poly(adp-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in dna metabolism. this modification follows dna damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of dna strand breaks. may link the dna damage surveillance network to the mitotic fidelity checkpoint. negatively influences the g1/s cell cycle progression without interfering with centrosome duplication.
9581	
9582	
9583	
9584	involved in cell wall synthesis where it is required for glycosylation. involved in cell cycle progression through cell- size checkpoint.
9585	
9586	
9587	converts big endothelin-1 to endothelin-1 (by similarity).
9588	
9589	forms critical branches in o-glycans.
9590	component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane (by similarity).
9591	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
9592	
9593	involved in the activation cascade of caspases responsible for apoptosis execution. at the onset of apoptosis it proteolytically cleaves poly(adp-ribose) polymerase (parp) at a 216-asp-|-gly-217 bond. cleaves and activates sterol regulatory element binding proteins (srebps) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. cleaves and activates caspase-6, -7 and -9. involved in the cleavage of huntingtin.
9594	
9595	required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. it inhibits the activity of the anaphase promoting complex by sequestering cdc20 until all chromosomes are aligned at the metaphase plate.
9596	may play a role in germ line formation.
9597	cooperates with ly96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. acts via myd88 and traf6, leading to nf-kappa-b activation, cytokine secretion and the inflammatory response. may also promote apoptosis in response to lipoproteins. recognizes mycoplasmal macrophage-activating lipopeptide-2kd (malp-2), soluble tuberculosis factor (stf), phenol-soluble modulin (psm) and b.burgdorferi outer surface protein a lipoprotein (ospa-l) cooperatively with tlr6.
9598	
9599	positive effector of bcr-stimulated responses. couples the b-cell antigen receptor (bcr) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase c-gamma-dependent pathway, when phosphorylated on tyr-342 and tyr-346. thus the differential phosphorylation of syk can determine the pathway by which bcr is coupled to the regulation of intracellular calcium ion (by similarity).
9600	furnishes a means for formation of correctly charged gln-trna(gln) through the transamidation of misacylated glu- trna(gln) in the mitochondria. the reaction takes place in the presence of glutamine and atp through an activated gamma-phospho- glu-trna(gln) (potential).
9601	could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.
9602	
9603	
9604	
9605	
9606	calcium-dependent, calmodulin-stimulated protein phosphatase. this subunit may have a role in the calmodulin activation of calcineurin. dephosphorylates hspb1 and ssh1.
9607	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
9608	
9609	
9610	
9611	inhibitor of actin polymerization.
9612	receptor for acidic fibroblast growth factor. does not bind to basic fibroblast growth factor. binds fgf19.
9613	involved in transport from the endoplasmic reticulum to the golgi apparatus. activated by the guanine nucleotide exchange factor preb. involved in the selection of the protein cargo and the assembly of the copii coat complex.
9614	excises uracil residues from the dna which can arise as a result of misincorporation of dump residues by dna polymerase or due to deamination of cytosine.
9615	
9616	involved in the formation of the lytic c5b-9m complex.
9617	
9618	plays a role in tight junctions and adherens junctions.
9619	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
9620	bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. catalyzes the formation of 3- ketoacyl-coa intermediates from both straight-chain and 2-methyl- branched-chain fatty acids.
9621	converts molybdopterin precursor z into molybdopterin. this requires the incorporation of two sulfur atoms into precursor z to generate a dithiolene group.
9622	thought to form a receptor-activated non-selective calcium permeant cation channel. probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or g-protein coupled receptors. activated by diacylglycerol (dag) (by similarity). may also be activated by intracellular calcium store depletion.
9623	
9624	
9625	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
9626	
9627	stimulates hepatic and intestinal proliferation.
9628	type i collagen is a member of group i collagen (fibrillar forming collagen).
9629	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
9630	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel. rho-2 gaba receptor could play a role in retinal neurotransmission.
9631	
9632	
9633	histone h3, along with histone h4, plays a central role in nucleosome formation.
9634	may be involved in transcriptional regulation.
9635	histone h3, along with histone h4, plays a central role in nucleosome formation.
9636	may be involved in cell-cell interactions and recognition.
9637	cytokine that binds to ltbr/tnfrsf3. may play a specific role in immune response regulation. provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. isoform 2 is probably non-functional.
9638	probable guanine nucleotide exchange factor. putative effector of ras and/or rap. associates with the gtp-bound form of rap 1a and h-ras in vitro (by similarity).
9639	
9640	
9641	
9642	specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3@#$%&end of 16s rrna in the 30s particle. its inactivation leads to kasugamycin resistance.
9643	
9644	not known; potential regulator of cellular growth.
9645	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell. may play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.
9646	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
9647	subunit of the peripheral v1 complex of vacuolar atpase essential for assembly or catalytic function. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
9648	interacts selectively in vitro with the af2-activating domain of the estrogen receptors. association with dna-bound estrogen receptors requires the presence of estradiol.
9649	can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses. may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
9650	
9651	acts as a factor that allows the dna to undergo a single round of replication per cell cycle. required for dna replication and cell proliferation. required for s-phase checkpoint activation upon uv-induced damage.
9652	
9653	
9654	the intermediate chains seem to help dynein bind to dynactin 150 kda component. may play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
9655	plays a role in u6 snrnp assembly and function. binds to the 3@#$%& end of u6 snrna, thereby facilitating u4/u6 duplex formation in vitro.
9656	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to sites in the 5@#$%&-flanking sequence of its coding region with various affinities. the consensus sequences of the high and low affinity binding sites are 5@#$%&-taatga[cg]-3@#$%& and 5@#$%&-ctaatttt- 3@#$%&.
9657	
9658	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
9659	
9660	
9661	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes and then transfers it to substrates (by similarity).
9662	
9663	interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. can also catalyze the reaction of ec 5.4.2.4 (synthase) and ec 3.1.3.13 (phosphatase), but with a reduced activity.
9664	
9665	
9666	binds to cntf. the alpha chain provides the receptor specificity.
9667	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
9668	adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (hat), which gives a specific tag for epigenetic transcription activation. plays a central role in myc (c-myc) transcription activation, and also participates in cell transformation by myc. required for p53/tp53-, e2f1- and e2f4-mediated transcription activation. also involved in transcription activation mediated by the adenovirus e1a, a viral oncoprotein that deregulates transcription of key genes. probably acts by linking transcription factors such as e1a, myc or e2f1 to hat complexes such as staga thereby allowing transcription activation. probably not required in the steps following histone acetylation in processes of transcription activation. may be required for the mitotic checkpoint and normal cell cycle progression.
9669	may be involved in transcriptional regulation.
9670	collagen type iv is specific for basement membranes.
9671	recruits tfiih to the initiation complex and stimulates the rna polymerase ii c-terminal domain kinase and dna-dependent atpase activities of tfiih. both tfiih and tfiie are required for promoter clearance by rna polymerase.
9672	
9673	involved in dna repair and mitotic recombination. may play an active role in recombination processes in concert with other members of the rad52 epistasis group.
9674	this protein also expresses aconitase activity.
9675	
9676	this protein also expresses aconitase activity.
9677	component of the large subunit of mitochondrial ribosome.
9678	
9679	mediates estrogen action in various target organs.
9680	cooperates with tlr4 in the innate immune response to bacterial lipopolysaccharide (lps), and with tlr2 in the response to cell wall components from gram-positive and gram-negative bacteria. enhances tlr4-dependent activation of nf-kappa-b. cells expressing both md2 and tlr4, but not tlr4 alone, respond to lps.
9681	golgi auto-antigen; probably involved in maintaining cis-golgi structure.
9682	two step nadp-dependent conversion of gdp-4-dehydro-6- deoxy-d-mannose to gdp-fucose, involving an epimerase and a reductase reaction.
9683	
9684	has a potent tumor cell motility-stimulating activity.
9685	type i collagen is a member of group i collagen (fibrillar forming collagen).
9686	may play a role in macrophage activation and function.
9687	may be implicated in biomineralization processes. has a function in binding of osteoblasts via the alpha(v)beta(3)- integrin (by similarity).
9688	oxidation of 5,6-dihydroxyindole-2-carboxylic acid (dhica) into indole-5,6-quinone-2-carboxylic acid. may regulate or influence the type of melanin synthesized.
9689	phosphorylates znf622 and may contribute to its redirection to the nucleus. may be involved in the inhibition of spliceosome assembly during mitosis.
9690	
9691	
9692	calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. this protein regulates phospholipase a2 activity. it seems to bind from two to four calcium ions with high affinity.
9693	important for the overall degradation of proteins in lysosomes.
9694	
9695	
9696	may serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins (by similarity).
9697	
9698	binds specifically and noncooperatively to the sph and gt-iic @#$%!enhansons@#$%! (5@#$%&-gtggaatgt-3@#$%&) and activates transcription. binds to the m-cat motif (by similarity).
9699	
9700	protein transport. probably involved with ras-related protein rab-3a in synaptic vesicle traffic and/or synaptic vesicle fusion. could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
9701	
9702	involved in the maturation of asn-linked oligosaccharides. trim a single alpha-1,2-linked mannose residue from man(9)glcnac(2) to produce man(8)glcnac(2). the only product is the man(8)glcnac(2) isomer b, the form lacking the middle-arm terminal alpha 1,2-mannose. it may be involved in glycoprotein quality control since it is important to target misfolded glycoproteins for degradation.
9703	
9704	
9705	sodium-phosphate symporter. active in early growth phase.
9706	
9707	adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. may link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
9708	putative target protein of adp-ribosylation factor.
9709	receptor for members of the ephrin-b family. binds to ephrin-b1 and -b2.
9710	
9711	
9712	may be involved in the regulation of gene expression by covalent modification of histone proteins. the long isoform is a corepressor of estrogen receptor (er). the short isoform binds to er and sequesters it in the cytoplasm and enhances non-genomic responses of er.
9713	
9714	
9715	pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces.
9716	the elongation of primed dna templates by dna polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (pcna) and activator 1.
9717	
9718	
9719	
9720	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes, such as ube2l3/ubcm4, and then transfers it to substrates.
9721	participates in the detoxification of a plethora of hydrazine and arylamine drugs. catalyzes the n- or o-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
9722	
9723	
9724	
9725	
9726	plays a role in the formation of functional neural circuits from the early stages of synapse formation. has a role in the development of cns functions involved in locomotor activity.
9727	protein transport. probably involved in vesicular traffic (by similarity).
9728	transcriptional repressor.
9729	binds highly specifically to rhoa, rhoc and rac proteins, but does not appear to catalyze guanine nucleotide exchange (by similarity).
9730	may play a role in junctional plaques.
9731	
9732	
9733	plays a role as an intracellular lectin in the early secretory pathway. interacts with n-acetyl-d-galactosamine and high-mannose type glycans and may also bind to o-linked glycans. involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (by similarity).
9734	involved in the presentation of foreign antigens to the immune system.
9735	may be involved in transcriptional regulation.
9736	
9737	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
9738	possible cell adhesion receptor. it possesses an intrinsic protein tyrosine phosphatase activity (ptpase). it controls motor axon guidance.
9739	serine/threonine-protein kinase that acts as a molecular sensor for dna damage. involved in dna nonhomologous end joining (nhej) required for double-strand break (dsb) repair and v(d)j recombination. must be bound to dna to express its catalytic properties. promotes processing of hairpin dna structures in v(d)j recombination by activation of the hairpin endonuclease artemis (dclre1c). the assembly of the dna-pk complex at dna ends is also required for the nhej ligation step. required to protect and align broken ends of dna. may also act as a scaffold protein to aid the localization of dna repair proteins to the site of damage. found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. also involved in modulation of transcription. recognizes the substrate consensus sequence [s/t- q]. phosphorylates ser-139 of histone variant h2ax/h2afx, thereby regulating dna damage response mechanism. phosphorylates dclre1c, c1d, c-abl/abl1, histone h1, hspca, c-jun/jun, p53/tp53, parp1, pou2f1, dhx9, srf, xrcc1, xrcc1, xrcc4, xrcc5, xrcc6, wrn, c- myc/myc and rfa2.
9740	
9741	nmda receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine. this protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. it mediates neuronal functions in glutamate neurotransmission. is involved in the cell surface targeting of nmda receptors (by similarity).
9742	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. binds to bmp-7, bmp-2 and, less efficiently, bmp-4. binding is weak but enhanced by the presence of type i receptors for bmps.
9743	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
9744	
9745	may enhance the cell surface expression of odorant receptors (by similarity).
9746	not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. antigen recognized on a melanoma by autologous cytolytic t-lymphocytes.
9747	
9748	may be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction.
9749	
9750	
9751	
9752	
9753	key enzyme in the regulation of glycerol uptake and metabolism.
9754	promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. interaction with flna may allow neuroblast migration from the ventricular zone into the cortical plate. tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (by similarity).
9755	
9756	plays an important role in the organization of the cytoskeleton. binds to and sequesters actin monomers (g actin) and therefore inhibits actin polymerization (by similarity).
9757	
9758	may play a role in organizing the actin cytoskeleton.
9759	
9760	
9761	
9762	this enzyme is specific for acyl chain lengths of 4 to 16.
9763	
9764	
9765	initiates complex n-linked carbohydrate formation. essential for the conversion of high-mannose to hybrid and complex n-glycans.
9766	
9767	potentiates but cannot initiate fas-induced apoptosis.
9768	
9769	may play a role in regulating interactions between dynein and p150-glued, and the cellular substrates for dynein- mediated motility (such as organelles) (by similarity).
9770	
9771	peripherin are class-iii neuronal intermediate filament proteins.
9772	
9773	plays an important role in the eukaryotic peptide chain initiation process (by similarity).
9774	
9775	expressed on cytokine induced endothelial cells and mediates their binding to leukocytes. the ligand recognized by elam-1 is sialyl-lewis x (alpha(1->3)fucosylated derivatives of polylactosamine that are found at the nonreducing termini of glycolipids).
9776	
9777	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. this protein may be involved in the regulation of b-cell activation and proliferation.
9778	
9779	3beta-hsd is a bifunctional enzyme, that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. the 3beta-hsd enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
9780	
9781	enhances transcription activation by yy1.
9782	
9783	
9784	
9785	isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
9786	
9787	
9788	
9789	
9790	
9791	
9792	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
9793	required for centriole duplication. inhibition of centriole duplication leading to defects in cytokinesis.
9794	
9795	
9796	receptor for both octopamine and tyramine, invertebrate neurotransmitters, and neuromodulators. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase. the rank order of potency for agonists is tyramine > octopamine > dopamine > epinephrine > norepinephrine > serotonin > histamine. for antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > cyproheptadine > dihydroergotamine > clonidine > synephrine. tyramine has a functional role in the olfactory system as a neurotransmitter or a neuromodulator.
9797	
9798	involved in intracellular vesicle trafficking.
9799	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator.
9800	
9801	
9802	may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes (by similarity).
9803	
9804	crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. important in mediating the effect of ldl (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-coa reductase and activation of endogenous cellular cholesteryl ester formation.
9805	binds to the lim domain of a wide variety of lim domain- containing transcription factors. may be involved in the development of motor neurons.
9806	
9807	receptor for prolactin-releasing peptide (prrp). implicated in lactation, regulation of food intake and pain-signal processing.
9808	
9809	protease that regulate the availability of igfs by cleaving igf-binding proteins.
9810	nad-dependent histone deacetylase involved in telomeric silencing. histone deacetylase proteins act via the formation of large multiprotein complexes that are responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. restores silencing at hmr in sir2 mutants when overexpressed. required to repress middle sporulation genes during vegetative growth. acts as a sensor of nad(+) levels and regulator of nad(+) biosynthesis. regulates the gene expression of de novo nad(+) biosynthesis genes.
9811	
9812	
9813	
9814	
9815	protects the body from potent vasoactive and inflammatory peptides containing c-terminal arg or lys (such as kinins or anaphylatoxins) which are released into the circulation.
9816	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (by similarity). probably encodes a dihydropyridine-insensitive current. vital for survival to adulthood.
9817	
9818	
9819	ras proteins bind gdp/gtp and possess intrinsic gtpase activity.
9820	
9821	activates the jun n-terminal pathway. required for serum-stimulated cell proliferation and for mitogen and cytokine activation of mapk14 (p38), mapk3 (erk) and mapk8 (jnk1). plays a role in mitogen-stimulated phosphorylation and activation of braf, but does not phosphorylate braf directly. influences microtubule organization during the cell cycle.
9822	involved in redox regulation of the cell. can reduce h(2)o(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
9823	
9824	one of the multiple factors required for polyadenylation and 3@#$%&-end cleavage of mammalian pre-mrnas.
9825	the long isoform may play a role in neural and glial cell adhesion in the developing embryo. the short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. vital for embryonic development. essential for septate junctions. septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. required for the blood-brain barrier formation.
9826	apoptotic suppressor. the bir motifs region interacts with tnf receptor associated factors 1 and 2 (traf1 and traf2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (tnfr2).
9827	binds to dna sequences containing the consensus nucleotide core sequence ggaa.
9828	probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. also required for the transfer of beta-barrel precursors from the tom complex to the sorting and assembly machinery (sam complex) of the outer membrane. acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (by similarity).
9829	
9830	the cd3 complex mediates signal transduction.
9831	tetrapolymerization of the monopyrrole pbg into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
9832	catalyzes a dehydrogenation to introduce c5-6 double bond into lathosterol.
9833	may play a role in tumorigenesis as a tumor suppressor. altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis.
9834	appears to play a role in the switch from cap-dependent to ires-mediated translation during mitosis, apoptosis and viral infection. cleaved by some caspases and viral proteases.
9835	
9836	
9837	
9838	
9839	may regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. might be involved in the regulation of general functions of integrins.
9840	
9841	
9842	
9843	
9844	
9845	golgi auto-antigen; probably involved in maintaining golgi structure.
9846	
9847	probably involved in the control of the cell cycle. interacts with cyclins a, b3, d, or e. activity of cdk2 is maximal during s phase and g2.
9848	
9849	seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit kpnb1. acting autonomously, is thought to serve itself as receptor for nuclear localization signals (nls) and to promote translocation of import substrates through the nuclear pore complex (npc) by an energy requiring, ran-dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. in vitro mediates the nuclear import of srp19.
9850	
9851	
9852	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression.
9853	acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
9854	cysteine protease required for autophagy, which cleaves the c-terminal part of either map1lc3, gabarapl2 or gabarap, allowing the liberation of form i. a subpopulation of form i is subsequently converted to a smaller form (form ii). form ii, with a revealed c-terminal glycine, is considered to be the phosphatidylethanolamine (pe)-conjugated form, and has the capacity for the binding to autophagosomes.
9855	
9856	
9857	receptor that may play a role in the perception of bitterness and is gustducin-linked. may play a role in sensing the chemical composition of the gastrointestinal content. the activity of this receptor may stimulate alpha gustducin, mediate plc-beta-2 activation and lead to the gating of trpm5 (by similarity).
9858	receptor that may play a role in the perception of bitterness and is gustducin-linked. may play a role in sensing the chemical composition of the gastrointestinal content. the activity of this receptor may stimulate alpha gustducin, mediate plc-beta-2 activation and lead to the gating of trpm5 (by similarity).
9859	
9860	
9861	required for protein transport from the er to the golgi complex.
9862	
9863	plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. the tripartite complex composed of lin7 (lin7a, lin7b or lin7c), cask and apba1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. ensures the proper localization of grin2b (subunit 2b of the nmda receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. required to localize kir2 channels, gaba transporter (slc6a12) and egfr/erbb1, erbb2, erbb3 and erbb4 to the basolateral membrane of epithelial cells.
9864	
9865	may function as signal-transmitting receptor.
9866	
9867	
9868	
9869	
9870	cytokine that binds to tnfrsf11b/opg and to tnfrsf11a/rank. osteoclast differentiation and activation factor. augments the ability of dendritic cells to stimulate naive t-cell proliferation. may be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
9871	may function as a transcription factor.
9872	
9873	ubiquitin-like modifier protein which binds to a number of as yet unidentified target proteins.
9874	
9875	may play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. may modulate sc6a1/gat1-mediated gaba uptake by stabilizing the transporter. required for localization of vil2 to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (by similarity).
9876	
9877	
9878	transcriptional activator binding to the e-box 1 core sequence of the e-cadherin promoter gene; the core-binding sequence is 5@#$%&caggtg-3@#$%&. capable of reversing ctbp1-mediated transcription repression. also participates in the regulation of alternative pre-mrna splicing. associates to spliced mrna within 60 nt upstream of the 5@#$%& splice sites. involved in the establishment and maintenance of epithelia cell-cell adhesion. potential tumor suppressor for renal cell carcinoma.
9879	required for pseudopod elongation in transformed cells.
9880	sodium-independent exchanger of cationic and large neutral amino acids.
9881	guanine nucleotide exchange factor that potentially links pathways that signal through rac1, rhoa and cdc42. catalyzes guanine nucleotide exchange on rhoa and cdc42 and interacts specifically with the gtp-bound form of rac1, suggesting that it functions as an effector of rac1. may also participate in axonal transport in the brain. becomes activated and highly tumorigenic by truncation of the n-terminus (by similarity).
9882	may be involved in transcriptional regulation.
9883	
9884	
9885	
9886	
9887	component of the cleavage and polyadenylation specificity factor (cpsf) complex that play a key role in pre-mrna 3@#$%&-end formation, recognizing the aauaaa signal sequence and interacting with poly(a) polymerase and other factors to bring about cleavage and poly(a) addition.
9888	
9889	
9890	
9891	
9892	
9893	
9894	
9895	positive effector of bcr-stimulated responses. couples the b-cell antigen receptor (bcr) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase c-gamma-dependent pathway, when phosphorylated on tyr-342 and tyr-346. thus the differential phosphorylation of syk can determine the pathway by which bcr is coupled to the regulation of intracellular calcium ion.
9896	it is involved in repression by a1-alpha2 and alpha2 and in other systems as a general repressor of transcription. this protein has no obvious dna-binding domains. it might not interact directly with dna but with dna-bound proteins.
9897	
9898	binds preferentially single-stranded dna and unwinds double stranded dna.
9899	binds preferentially single-stranded dna and unwinds double stranded dna.
9900	
9901	may be involved in transcriptional regulation.
9902	
9903	transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (upr). acts during endoplasmic reticulum stress (er) by activating unfolded protein response (upr) target genes via direct binding to the upr element (upre). binds dna preferably to the cre-like element 5@#$%&- gatgacgtg[tg]n(3)[at]t-3@#$%&, and also to some tpa response elements (tre). binds to the hla dr-alpha promoter. binds to the tax- responsive element (tre) of htlv-i.
9904	
9905	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
9906	
9907	vinexin alpha isoform promotes up-regulation of actin stress fiber formation. vinexin beta isoform plays a role in cell spreading and enhances the activation of jnk/sapk in response to egf stimulation by using its third sh3 domain.
9908	
9909	
9910	may play a role in protein processing in limb, cardiac and reproductive system development.
9911	
9912	
9913	
9914	
9915	may be involved in transcriptional regulation. coactivator for steroid receptors.
9916	
9917	
9918	
9919	
9920	
9921	
9922	
9923	
9924	this protein promotes the gtp-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome.
9925	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
9926	
9927	
9928	
9929	binds to splice sites in pre-mrna and regulates splice site selection. binds and stabilizes cytoplasmic mrna. contributes to the regulation of translation by modulating the interaction between the mrna and eukaryotic initiation factors (by similarity). binds to promoters that contain a y-box (5@#$%&- ctgattggccaa-3@#$%&), such as hla class ii genes. regulates the transcription of numerous genes. promotes separation of dna strands that contain mismatches or are modified by cisplatin. has endonucleolytic activity and can introduce nicks or breaks into double-stranded dna (in vitro). may play a role in dna repair.
9930	required for 60s ribosomal subunit biogenesis.
9931	
9932	
9933	
9934	
9935	
9936	
9937	
9938	
9939	
9940	
9941	
9942	transcriptional activator that binds to the upstream enhancer region (ccac box) of myoglobin gene. has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli.
9943	
9944	
9945	
9946	
9947	
9948	
9949	
9950	
9951	
9952	may play a role in the formation and regulation of the tight junction (tj) paracellular permeability barrier. it is able to induce adhesion when expressed in cells lacking tight junctions.
9953	
9954	
9955	transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. potential role in g2/m cell cycle regulation (by similarity).
9956	
9957	
9958	associates with cyclin g and cdk5. seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by hsc70 in non-neuronal cells. expression oscillates slightly during the cell cycle, peaking at g1 (by similarity).
9959	
9960	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
9961	
9962	
9963	it may serve as a negative regulator of t-cell receptor (tcr) signaling via inhibition of calcineurin. interacts with and inhibits calcineurin-mediated signal transduction. cabin 1 is specific for the activated form of calcineurin, their interaction is dependent on both pkc and calcium signals.
9964	
9965	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. this protein may mediate formation of the complex between cytochromes c and c1.
9966	
9967	
9968	sodium-phosphate symporter. active in early growth phase.
9969	
9970	transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney (by similarity).
9971	
9972	
9973	
9974	the cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
9975	catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (ipp) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (dmapp).
9976	
9977	displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols.
9978	
9979	
9980	
9981	desmuslin is a type-vi intermediate filament which may function as a mechanical support to the muscle fibers by making a linkage between the extracellular matrix via the dystrophin- associated protein complex (dapc) and the z-disk.
9982	
9983	
9984	
9985	acts as a negative regulator of entry into mitosis (g2 to m transition) by two mechanisms. catalyzes the inhibitory phosphorylation of the cdc2 kinase specifically when the latter is complexed to cyclins. phosphorylation of cdc2 occurs predominantly on thr-14 (and maybe also to a lesser degree on tyr-15). may also inhibit mitotic entry by cytoplasmic retention of cdc2/ccnb1 complexes.
9986	may be involved in n-glycosylation through its association with n-oligosaccharyl transferase.
9987	
9988	dna- and rna binding protein, involved in several nuclear processes. essential pre-mrna splicing factor required early in spliceosome formation and for splicing catalytic step ii, probably as an heteromer with nono. binds to pre-mrna in spliceosome c complex, and specifically binds to intronic polypyrimidine tracts. interacts with u5 snrna, probably by binding to a purine-rich sequence located on the 3@#$%& side of u5 snrna stem 1b. may be involved in a pre-mrna coupled splicing and polyadenylation process as component of a snrnp-free complex with snrpa/u1a. the sfpq-nono heteromer associated with matr3 may play a role in nuclear retention of defective rnas. sfpq may be involved in homologous dna pairing; in vitro, promotes the invasion of ssdna between a duplex dna and produces a d-loop formation. the sfpq-nono heteromer may be involved in dna unwinding by modulating the function of topoisomerase i/top1; in vitro, stimulates dissociation of top1 from dna after cleavage and enhances its jumping between separate dna helices. the sfpq-nono heteromer may be involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination and may stabilize paired dna ends; in vitro, the complex strongly stimulates dna end joining, binds directly to the dna substrates and cooperates with the ku70/g22p1-ku80/xrcc5 (ku) dimer to establish a functional preligation complex. sfpq is involved in transcriptional regulation. transcriptional repression is probably mediated by an interaction of sfpq with sin3a and subsequent recruitment of histone deacetylases (hdacs). the sfpq-nono/sf-1 complex binds to the cyp17 promoter and regulates basal and camp- dependent transcriptional avtivity. sfpq isoform long binds to the dna binding domains (dbd) of nuclear hormone receptors, like rxra and probably thra, and acts as transcriptional corepressor in absence of hormone ligands. binds the dna sequence 5@#$%&-ctgagtc-3@#$%& in the insulin-like growth factor response element (igfre) and inhibits igf-i-stimulated transcriptional activity.
9989	
9990	
9991	
9992	potential tumor suppressor. acts as a phosphoinositide 3-phosphatase by regulating ptdins(3,4,5)p3 levels. involved in regulation of the akt1 signaling pathway. the unphosphorylated form cooperates with aip1 to suppress akt1 activation.
9993	histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a central role in histone code. preferentially demethylates mono- and dimethylated h3 lys-9 residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated h3 lys-9. demethylation of lys residue generates formaldehyde and succinate. involved in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes, resulting in h3 lys-9 demethylation and transcriptional activation.
9994	
9995	
9996	functions as a calcium permeable cation channel. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis.
9997	induces disassembly of actin filaments in conjunction with adf/cofilin family proteins (by similarity).
9998	
9999	
10000	
10001	
10002	
10003	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
10004	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
10005	
10006	participates in the folding of proteins containing disulfide bonds (by similarity).
10007	role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. may have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (by similarity).
10008	
10009	may be involved in several stages of intracellular trafficking. could play an important role in the regulation of glucose transport by insulin. may act as a downstream effector of rhoq/tc10 in the regulation of insulin-stimulated glucose transport (by similarity).
10010	
10011	
10012	acts as a receptor for sonic hedgehog (shh), indian hedgehog (ihh) and desert hedgehog (dhh). associates with the smoothened protein (smo) to transduce the hedgehog@#$%&s proteins signal. seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
10013	
10014	the pr65 subunit of protein phosphatase 2a serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory b subunit.
10015	receptor for il-10; binds il-10 with a high affinity.
10016	cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the peyer patches and the intestinal lamina propria. it can bind both integrin alpha-4/beta-7 and l-selectin, regulating both the passage and retention of leukocytes. isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of l- selectin binding.
10017	
10018	may function as an antagonist of fibroblast growth factor (fgf) pathways and may negatively modulate respiratory organogenesis.
10019	
10020	
10021	
10022	
10023	
10024	
10025	
10026	
10027	
10028	hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
10029	neuroleukin is a neurotrophic factor for spinal and sensory neurons.
10030	
10031	
10032	transcription factor that seems to function synergistically with the pou domain protein tst-1/oct6/scip. could confer cell specificity to the function of other transcription factors in developing and mature glia (by similarity).
10033	
10034	
10035	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
10036	
10037	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
10038	
10039	
10040	necessary for centrosome duplication.
10041	
10042	
10043	
10044	
10045	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
10046	
10047	
10048	involved in the presentation of foreign antigens to the immune system.
10049	
10050	
10051	
10052	
10053	
10054	
10055	
10056	
10057	
10058	
10059	
10060	
10061	
10062	
10063	
10064	
10065	
10066	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
10067	
10068	catalyzes the cyclization of (s)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
10069	
10070	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
10071	igf-1 leads to the activation of akt3, which may play a role in regulating cell survival. capable of phosphorylating several known proteins. truncated isoform 2/pkb gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
10072	
10073	adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. may regulate the formation of clathrin-coated vesicles. isoform 1 could be involved in brain-specific synaptic vesicle recycling.
10074	synthesis and degradation of fructose 2,6-bisphosphate.
10075	the heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.
10076	
10077	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i (by similarity).
10078	isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
10079	
10080	
10081	
10082	
10083	
10084	
10085	
10086	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
10087	
10088	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
10089	may function as a transcription factor. seems to repress transcription.
10090	
10091	may be involved in transcriptional regulation.
10092	component of the adaptor complexes which link clathrin to receptors in coated vesicles. clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. ap2s1/ap17 is a subunit of the plasma membrane adaptor. the complex binds polyphosphoinositides.
10093	
10094	
10095	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
10096	
10097	involved in the presentation of foreign antigens to the immune system.
10098	
10099	
10100	
10101	seems to mediate adhesion by cell surface integrin binding. may serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment.
10102	may have a special functional role during embryogenesis and in adult hematopoietic cells. binds to ubiquitin.
10103	catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
10104	catalyzes the initial reaction in o-linked oligosaccharide biosynthesis, the transfer of an n-acetyl-d- galactosamine residue to a serine or threonine residue on the protein receptor. has activity toward hiv envelope glycoprotein gp120, ea2, muc2 and muc5. probably glycosylates fibronectin in vivo. plays a central role in phosphate homeostasis.
10105	
10106	
10107	may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of e4tf1. in tumor cell lines, may induce apoptosis.
10108	may play a structural role at sites of cell adhesion in maintaining cell shape and motility. in addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. may be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
10109	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
10110	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase c. it could help neuronal cells to establish short- term memory.
10111	catalyzes the cleavage of l-kynurenine (l-kyn) and l-3- hydroxykynurenine (l-3ohkyn) into anthranilic (aa) and 3- hydroxyanthranilic acids (3-ohaa), respectively. has a preference for the l-3-hydroxy form. also has cysteine-conjugate-beta-lyase activity (by similarity).
10112	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
10113	
10114	
10115	
10116	thiol protease. has dipeptidylpeptidase activity. can act as both an exopeptidase and endopeptidase. activates serine proteases such as elastase, cathepsin g and granzymes a and b. can also activate neuraminidase and factor xiii.
10117	apoptotic suppressor. the bir motifs region interacts with tnf receptor associated factors 1 and 2 (traf1 and traf2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (tnfr2).
10118	
10119	orphan receptor.
10120	
10121	
10122	
10123	
10124	
10125	endopeptidase that degrades various components of the extracellular matrix. may activate progelatinase a.
10126	
10127	
10128	essential role in pre-mrna splicing.
10129	possible cell adhesion receptor. it possesses an intrinsic protein tyrosine phosphatase activity (ptpase). it controls motor axon guidance.
10130	binds ldl, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. in order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
10131	
10132	may be involved in several stages of intracellular trafficking (by similarity).
10133	
10134	
10135	
10136	
10137	
10138	dorsalizing factor. key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing tgf-beta family bone morphogenetic proteins (bmps) and sequestering them in latent complexes (by similarity).
10139	
10140	
10141	terminates the action of gaba by its high affinity sodium-dependent reuptake into presynaptic terminals (by similarity).
10142	
10143	
10144	
10145	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex. necessary for h(+) conduction (by similarity).
10146	receptor for the mcp-1, mcp-3 and mcp-4 chemokines. transduces a signal by increasing the intracellular calcium ions level. alternative coreceptor with cd4 for hiv-1 infection.
10147	
10148	
10149	
10150	
10151	
10152	
10153	
10154	
10155	
10156	
10157	
10158	
10159	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
10160	
10161	
10162	
10163	
10164	
10165	
10166	probable atp-binding rna helicase.
10167	
10168	
10169	
10170	anticoagulant plasma protein; it is a cofactor to activated protein c in the degradation of coagulation factors va and viiia. it helps to prevent coagulation and stimulating fibrinolysis.
10171	
10172	
10173	overproduction suppresses the slow growth phenotype of cpr7 mutant cells.
10174	plays a role in apical endocytosis/recycling. may be implicated in transport between the plasma membrane and early endosomes.
10175	
10176	interacts with dna-repair protein xrcc1 and can correct defective dna strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
10177	
10178	
10179	
10180	
10181	fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, dna, and actin. fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. interaction with tnr mediates inhibition of cell adhesion and neurite outgrowth (by similarity).
10182	apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. acts as an inhibitor of tnfrsf6 mediated apoptosis. a proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (disc) thereby blocking further recruitment and processing of caspase-8 at the complex. full length and shorter isoforms have been shown either to induce apoptosis or to reduce tnfrsf-triggered apoptosis. lacks enzymatic (caspase) activity.
10183	
10184	
10185	may act as a gtpase activating protein for rab family protein(s).
10186	
10187	
10188	vinexin alpha isoform promotes up-regulation of actin stress fiber formation. vinexin beta isoform plays a role in cell spreading and enhances the activation of jnk/sapk in response to egf stimulation by using its third sh3 domain.
10189	component of the cleavage factor im complex (cfim) that plays a key role in pre-mrna 3@#$%& processing. involved in association with nudt21/cpsf5 in pre-mrna 3@#$%&-end poly(a) site cleavage and poly(a) addition. cpsf6 binds to cleavage and polyadenylation rna substrates.
10190	
10191	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
10192	
10193	lif has the capacity to induce terminal differentiation in leukemic cells. its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
10194	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
10195	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
10196	
10197	
10198	
10199	protein transport. probably involved in vesicular traffic (by similarity).
10200	subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-golgi network (tgn) to the endosomal-lysosomal system.
10201	
10202	
10203	
10204	
10205	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
10206	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
10207	
10208	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
10209	binds with high affinity to rna molecules that contain au-rich elements (ares) found within the 3-prime untranslated regions of many protooncogenes and cytokine mrnas. also binds to double- and single-stranded dna sequences in a specific manner and functions a transcription factor. each of the rna-binding domains specifically can bind solely to a single-stranded non-monotonous 5@#$%&-uuag-3@#$%& sequence and also weaker to the single-stranded 5@#$%&- ttaggg-3@#$%& telomeric dna repeat. binding of rrm1 to dna inhibits the formation of dna quadruplex structure which may play a role in telomere elongation. may be involved in translationally coupled mrna turnover. implicated with other rna-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding-region determinant of instability (mcrd) domain.
10210	
10211	may act as scaffold protein.
10212	phosphorylates serine- and arginine-rich (sr) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable sr proteins to control rna splicing. phosphorylates serines, threonines and tyrosines. required for the regulation of alternative splicing of mapt/tau.
10213	may be involved in cell-cell interactions and recognition.
10214	in cooperation with other chaperones, hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. these chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. they bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
10215	
10216	
10217	growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. binds to the vegfr1/flt-1 and vegfr2/kdr receptors, heparan sulfate and heparin. neuropilin-1 binds isoforms vegf-165 and vegf-145.
10218	activates pro-caspase-1 and pro-caspase-8. potentiates casp8-mediated apoptosis. activates nf-kappa-b.
10219	
10220	
10221	
10222	
10223	
10224	essential for the control of the cell cycle at the g1/s (start) transition.
10225	
10226	receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxldl) by vascular endothelial cells. oxldl is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. its association with oxldl induces the activation of nf-kappa-b through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (no) release, monocyte adhesion and apoptosis. in addition to binding oxldl, it acts as a receptor for the hsp70 protein involved in antigen cross-presentation to naive t-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. also acts as a receptor for advanced glycation end (age) products, activated platelets, monocytes, apoptotic cells and both gram-negative and gram- positive bacteria.
10227	
10228	
10229	
10230	required for protein transport from the er to the golgi complex.
10231	
10232	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
10233	thyroid hormone-binding protein. probably transports thyroxine from the bloodstream to the brain.
10234	does not act as an allosteric activator of the cholera toxin catalytic subunit (by similarity).
10235	
10236	chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. signals through ccr2b and ccr3 receptors. plays a role in the accumulation of leukocytes at both sides of allergic and nonallergic inflammation. may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. may play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
10237	component of the dendritic ribonucleoprotein particles (rnps) in hippocampal neurons. may play a role in mrna transport.
10238	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
10239	has phospholipase and triglyceride lipase activities. hydrolyzes high density lipoproteins (hdl) more efficiently than other lipoproteins. binds heparin.
10240	
10241	chemotactic for eosinophils and basophils. binds to ccr3.
10242	
10243	putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.
10244	
10245	involved in intracellular signal transduction mediated by cytokines and growth factors. when associated with stam, it suppresses dna signaling upon stimulation by il-2 and gm-csf. could be a direct effector of pi3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. may concentrate ubiquitinated receptors within clathrin-coated regions. involved in down- regulation of receptor tyrosine kinase via multivesicular body (mvbs) when complexed with stam. this complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. may contribute to the efficient recruitment of smads to the activin receptor complex.
10246	atp-dependent rna helicase. acts as a cofactor for xpo1- mediated nuclear export of incompletely spliced hiv-1 rev rnas. also involved in hiv-1 replication. interacts specifically with hepatitis c virus core protein resulting in a change in intracellular location.
10247	involved in the transport of proteins between the endosomes and the trans golgi network (by similarity).
10248	
10249	
10250	may act as a scaffolding protein within caveolar membranes. interacts directly with g-protein alpha subunits and can functionally regulate their activity (by similarity).
10251	
10252	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
10253	
10254	
10255	
10256	
10257	
10258	
10259	
10260	
10261	
10262	
10263	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
10264	
10265	
10266	
10267	
10268	
10269	
10270	
10271	
10272	
10273	
10274	
10275	
10276	
10277	
10278	
10279	
10280	component of the mrn complex, which plays a central role in double-strand break (dsb) repair, dna recombination, maintenance of telomere integrity and meiosis. the complex possesses single-strand endonuclease activity and double-strand- specific 3@#$%&-5@#$%& exonuclease activity, which are provided by mre11a. rad50 may be required to bind dna ends and hold them in close proximity. this could facilitate searches for short or long regions of sequence homology in the recombining dna templates, and may also stimulate the activity of dna ligases and/or restrict the nuclease activity of mre11a to prevent nucleolytic degradation past a given point. the complex may also be required for dna damage signaling via activation of the atm kinase. in telomeres the mrn complex may modulate t-loop formation.
10281	
10282	
10283	
10284	regulatory subunit of a gtpase activating protein that has specificity for rab3 subfamily (rab3a, rab3b, rab3c and rab3d). rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. rab3 gtpase-activating complex specifically converts active rab3-gtp to the inactive form rab3- gdp. required for normal eye and brain development. may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and nonsynaptic vesicular release of neurotransmitters.
10285	plays a role in papillomavirus genes transcription.
10286	could be a global transcriptional regulator. modifies gene expression by affecting chromatin. may be involved in brain development and facial morphogenesis.
10287	
10288	contactins mediate cell surface interactions during nervous system development. involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with cntnap1. participates in oligodendrocytes generation by acting as a ligand of notch1. its association with notch1 promotes notch1 activation through the released notch intracellular domain (nicd) and subsequent translocation to the nucleus. interaction with tnr induces a repulsion of neurons and an inhibition of neurite outgrowth (by similarity).
10289	acts as a regulatory subunit of the 26 proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
10290	essential multidomain scaffolding protein required for normal development (by similarity). recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. may play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.
10291	transcriptional repressor.
10292	
10293	
10294	it is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. catalyzes the addition of n-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of n-linked sugar chains. it is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.
10295	cleaves ubiquitin fusion protein substrates. binds to the herpes virus protein vmw110 which may therefore modulate its substrate specificity or activity to stabilize viral proteins.
10296	probable transcriptional regulator involved in developmental processes.
10297	catalyzes the posttranslational methylation of isoprenylated c-terminal cysteine residues.
10298	
10299	
10300	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
10301	probable scaffold protein that may be involved in mrna transport (potential).
10302	
10303	
10304	
10305	can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses. may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
10306	receptor for the hormone galanin. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity.
10307	
10308	
10309	functions as a sorting receptor in the golgi compartment and as a clearance receptor on the cell surface. required for protein transport from the golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (m6pr). also required for protein transport from the golgi apparatus to the endosomes. promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of bdnf (probdnf) and ngfb (prongfb). also acts as a receptor for neurotensin. may promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular lpl. probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter slc2a4/glut4 (glut4 storage vesicles, or gsvs). these vesicles provide a stable pool of slc2a4 and confer increased responsiveness to insulin. may also mediate transport from the endoplasmic reticulum to the golgi.
10310	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release. inhibits both auto-ubiquitination of park2 and ubiquitination of target proteins by park2 (by similarity).
10311	catalyzes c14-demethylation of lanosterol; it transforms lanosterol into 4,4@#$%&-dimethyl cholesta-8,14,24-triene-3-beta-ol.
10312	
10313	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. mct2 is a high affinity pyruvate transporter.
10314	
10315	
10316	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1a gives rise to p and/or q-type calcium currents. p/q-type calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group and are blocked by the funnel toxin (ftx) and by the omega-agatoxin- iva (omega-aga-iva). they are however insensitive to dihydropyridines (dhp), and omega-conotoxin-gvia (omega-ctx-gvia).
10317	degrades extracellular matrix. exhibits trypsin-like activity as defined by cleavage of synthetic substrates with arg or lys as the p1 site (by similarity).
10318	
10319	
10320	cellular role is not yet known.
10321	receptor involved in the costimulatory signal essential for t-lymphocyte proliferation and interleukin 2 production, by binding cd28 or ctla-4. may play a critical role in the early events of t-cell activation and costimulation of naive t-cells, such as deciding between immunity and anergy that is made by t- cells within 24 hours after activation. isoform 2 interferes with the formation of cd86 clusters, and thus acts as a negative regulator of t-cell activation.
10322	
10323	
10324	essential multidomain scaffolding protein required for normal development (by similarity). recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. may play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.
10325	
10326	in vitro, acts as a receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5).
10327	probable morphogenetic role. may play a role in limb- pattern formation. in osteoblasts, suppresses transcription driven by the osteocalcin fgf response element (ocfre).
10328	
10329	protein transport. regulator of membrane traffic from the golgi apparatus towards the endoplasmic reticulum (er). has a low gtpase activity.
10330	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
10331	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
10332	
10333	
10334	plays a role in apical endocytosis/recycling. may be implicated in transport between the plasma membrane and early endosomes.
10335	inhibitor of protein-phosphatase 1. this protein may be important in hormonal control of glycogen metabolism. hormones that elevate intracellular camp increase i-1 activity in many tissues. i-1 activation may impose camp control over proteins that are not directly phosphorylated by pka. following a rise in intracellular calcium, i-1 is inactivated by calcineurin (or pp2b). does not inhibit type-2 phosphatases.
10336	
10337	may be a negative regulator of transcription, but can activate transcription when coexpressed with ras, src or mos. forms a ternary complex with the serum response factor and the ets and srf motifs of the fos serum response element.
10338	stimulates the proliferation of mast cells. able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. mediates also cell-cell adhesion. acts synergistically with other cytokines, probably interleukins.
10339	acts at e2f-responsive promoters to integrate signals provided by phd- and/or bromodomain-containing transcription factors (by similarity).
10340	may be involved in transcriptional regulation.
10341	
10342	
10343	shows chemotactic activity for monocytes, resting t- lymphocytes, and neutrophils, but not for activated lymphocytes. inhibits proliferation of myeloid progenitor cells in colony formation assays. this protein can bind heparin. binds ccr1. ccl23(19-99), ccl23(22-99), ccl23(27-99), ccl23(30-99) are more potent chemoattractants than the small inducible cytokine a23.
10344	regulates the gdp/gtp exchange reaction of the rho proteins by inhibiting the dissociation of gdp from them, and the subsequent binding of gtp to them (by similarity).
10345	required for protein transport from the er to the golgi complex.
10346	
10347	
10348	
10349	
10350	involved in tethering the chromosomes to the spindle pole and in chromosome movement. microtubule-based anterograde translocator for membranous organelles. plus end-directed microtubule sliding activity in vitro (by similarity).
10351	has peptide-independent atpase activity.
10352	
10353	responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. may play a role in the transport of porphyrins and heme.
10354	stimulates the gtpase activity of tubulin, but does not enhance tubulin heterodimerization. acts as guanine nucleotide dissociation inhibitor for arl3.
10355	unknown. may be involved in differentiation of metanephric precursor cells.
10356	
10357	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
10358	
10359	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
10360	
10361	
10362	
10363	
10364	
10365	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
10366	the soluble isoform 2 binds vegf-165 and appears to inhibit its binding to cells. it may also induce apoptosis by sequestering vegf-165. may bind as well various members of the semaphorin family. its expression has an averse effect on blood vessel number and integrity.
10367	
10368	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
10369	
10370	
10371	may be involved in transcriptional regulation.
10372	specific receptor for the autocrine motility factor.
10373	
10374	
10375	
10376	
10377	
10378	
10379	
10380	
10381	
10382	
10383	
10384	
10385	
10386	
10387	
10388	
10389	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
10390	
10391	binds single-stranded rna. has a high affinity for g- rich and u-rich regions of hnrna. also binds to apob mrna transcripts around the rna editing site.
10392	
10393	
10394	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
10395	activates erythroid-specific, globin gene expression.
10396	
10397	
10398	interacts with c-terminus of pcna. 5@#$%& phosphate residue is required for binding of the n-terminal dna-binding domain to duplex dna, suggesting a role in recognition of non-primer template dna structures during replication and/or repair.
10399	transcriptional corepressor that binds to a number of transcription factors. inhibits the transcriptional activation mediated by ctnnb1 and tcf family members in wnt signaling. the effects of full-length tle family members may be modulated by association with dominant-negative aes (by similarity).
10400	rapidly transports ca(2+) during excitation-contraction coupling. ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
10401	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of the calcium.
10402	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of the calcium.
10403	the soluble isoform 2 binds vegf-165 and appears to inhibit its binding to cells. it may also induce apoptosis by sequestering vegf-165. may bind as well various members of the semaphorin family. its expression has an averse effect on blood vessel number and integrity.
10404	
10405	
10406	
10407	may be involved in transcriptional regulation.
10408	could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by ngf. may be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (by similarity).
10409	involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. shows high catalytic efficiency for hydrolysis of 4-methyumbelliferyl acetate, heroin and 6-monoacetylmorphine.
10410	
10411	functions in the early steps of protein synthesis by forming a ternary complex with gtp and initiator trna. this complex binds to a 40s ribosomal subunit, followed by mrna binding to form a 43s preinitiation complex. junction of the 60s ribosomal subunit to form the 80s initiation complex is preceded by hydrolysis of the gtp bound to eif-2 and release of an eif-2-gdp binary complex. in order for eif-2 to recycle and catalyze another round of initiation, the gdp bound to eif-2 must exchange with gtp by way of a reaction catalyzed by eif-2b.
10412	glycosyltransferase that initiates the elongation of o- linked fucose residues attached to egf-like repeats in the extracellular domain of notch molecules. may be involved in limb formation and in neurogenesis (by similarity).
10413	major component of the descemet@#$%&s membrane (basement membrane) of corneal endothelial cells.
10414	involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26s proteasome (by similarity).
10415	
10416	
10417	
10418	isoform gamma is a site-specific single-strand endoribonuclease that cleaves single strand rna 3@#$%& to purines and pyrimidines in a+u-rich regions. it generates 5@#$%&-phosphate termini at the site of cleavage. this isoform does not inhibit pp-1. may be implicated in mrna splicing.
10419	
10420	
10421	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis (by similarity).
10422	this protein is a minor sialoglycoprotein in human erythrocyte membranes. the blood group gerbich antigens and receptors for plasmodium falciparum merozoites are most likely located within the extracellular domain. glycophorin c plays an important role in regulating the stability of red cells.
10423	
10424	
10425	adds a myristoyl group to the n-terminal glycine residue of certain cellular and viral proteins.
10426	
10427	may be involved in several stages of intracellular trafficking (by similarity).
10428	
10429	cleaves the propeptides of type i and ii collagen prior to fibril assembly. does not act on type iii collagen. may also play a role in development that is independent of its role in collagen biosynthesis.
10430	
10431	may activate cdc42, a member of the ras-like family of rho- and rac proteins, by exchanging bound gdp for free gtp. may play a role in regulating the actin cytoskeleton and cell shape (by similarity).
10432	
10433	
10434	
10435	
10436	muscle contraction.
10437	
10438	
10439	polymerase that creates the 3@#$%& poly(a) tail of mrna@#$%&s. also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. may acquire specificity through interaction with a cleavage and polyadenylation specificity factor (cpsf) at its c-terminus.
10440	
10441	
10442	adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. can bind to fibrinogen, fibronectin, laminin, type v collagen and integrins alpha-v/beta-1, alpha- v/beta-3 and alpha-iib/beta-3.
10443	
10444	
10445	
10446	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
10447	atp-dependent rna helicase involved nonsense-mediated mrna decay and ribosome biogenesis through rrna processing.
10448	may play some role in mitochondrial processes.
10449	inhibits nf-kappa-b activation. may participate in a regulatory mechanism that coordinates cellular responses controlled by nf-kappa-b transcription factor. may be a component of the inflammasome, a protein complex which also includes pycard, nalp2 and casp1 and whose function would be the activation of proinflammatory caspases.
10450	
10451	
10452	acts on phosphatidylinositol (ptdins) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate.
10453	probably involved in the organization of the actin cytoskeleton. induced membrane extensions in fibroblasts.
10454	
10455	
10456	
10457	
10458	
10459	
10460	
10461	immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. participates also in the recruitment of tyrosine kinase syk.
10462	
10463	
10464	
10465	
10466	
10467	
10468	
10469	
10470	
10471	
10472	
10473	
10474	
10475	
10476	
10477	
10478	
10479	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
10480	
10481	
10482	
10483	component of adherens-type cell-cell and cell-matrix junctions. lacks phosphoglucomutase activity.
10484	
10485	
10486	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
10487	plays a role in modulation of e3 ubiquitin ligase activity of the 2 subunit brca1/bard1 complex.
10488	
10489	transcription factor that binds to the octamer motif (5@#$%&-atttgcat-3@#$%&). prime candidate for an early developmental control gene.
10490	
10491	
10492	
10493	implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.
10494	
10495	
10496	motor required for the retrograde transport of golgi vesicles to the endoplasmic reticulum. has a microtubule plus end- directed motility.
10497	
10498	required for protein transport from the er to the golgi complex.
10499	
10500	
10501	
10502	
10503	
10504	molecular chaperone. has atpase activity (by similarity).
10505	component of a protein kinase signal transduction cascade. activates the jnk, but not erk or p38 kinase pathways.
10506	
10507	
10508	sequence-specific rna-binding protein which participates in the control of pre-mrna splicing.
10509	catalyzes the reaction that attaches fucose through an o-glycosidic linkage to a conserved serine or threonine residue in thrombospondin type 1 repeats.
10510	core component of nucleosome. nucleosomes wrap and compact dna into chromatin, limiting dna accessibility to the cellular machineries which require dna as a template. histones thereby play a central role in transcription regulation, dna repair, dna replication and chromosomal stability. dna accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodelling.
10511	can unwind double-stranded rna (helicase) and can fold or introduce a secondary structure to a single-stranded rna (foldase). functions as cofactor for c-jun-activated transcription (by similarity).
10512	
10513	
10514	
10515	3@#$%&-exoribonuclease that has a preference for poly(a) tails of mrnas, thereby efficiently degrading poly(a) tails. exonucleolytic degradation of the poly(a) tail is often the first step in the decay of eukaryotic mrnas and is also used to silence certain maternal mrnas translationally during oocyte maturation and early embryonic development. interacts with both the 3@#$%&-end poly(a) tail and the 5@#$%&-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(a) tails. involved in nonsense-mediated mrna decay, a critical process of selective degradation of mrnas that contain premature stop codons. also involved in degradation of inherently unstable mrnas that contain au-rich elements (ares) in their 3@#$%& untranslated regions, possibly via its interaction with khsrp. probably mediates the removal of poly(a) tails of ares mrnas, which constitutes the first step of destabilization.
10516	
10517	
10518	
10519	
10520	
10521	involved in dna double strand break (dsb) repair.
10522	
10523	
10524	a probable role in alternative splice site selection during pre-mrna splicing.
10525	receptor for obesity factor (leptin). on ligand binding, mediates signaling through jak2/stat3. involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. may play a role in reproduction. can also mediate the erk/fos signaling pathway (by similarity).
10526	
10527	
10528	
10529	
10530	phosphorylase is an important allosteric enzyme in carbohydrate metabolism. enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. however, all known phosphorylases share catalytic and structural properties.
10531	catalyzes the covalent attachment of ubiquitin to other proteins. mediates the selective degradation of short-lived and abnormal proteins.
10532	
10533	receptor for a c-c type chemokine. binds to mip-1-alpha, mip-1-delta, rantes, and mcp-3 and, less efficiently, to mip-1- beta or mcp-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. responsible for affecting stem cell proliferation.
10534	inhibits the auto- and transphosphorylation activity of btk. plays a negative regulatory role in btk-related cytoplasmic signaling in b-cells. may be involved in bcr-induced apoptotic cell death.
10535	component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. three proteases; ndl, gd and snk process easter to create active easter. active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the tl receptor in the ventral region of the embryo. promotes heterophilic cellular adhesion. spz c-106 in the hemolymph controls expression of the antifungal peptide drosomycin (drs) by acting as a ligand of tl and inducing an intracellular signaling pathway.
10536	probably has no proteolytic activity, since crucial aa characteristic of serine proteases catalytic sites are not conserved.
10537	
10538	may regulate vesicle function in the growth cone (by similarity).
10539	
10540	
10541	
10542	
10543	
10544	prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (er). binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (srp), which normally targets nascent secretory peptides to the er. also reduces the inherent affinity of ribosomes for protein translocation sites in the er membrane (m sites). may act as a specific coactivator for jun, binding to dna and stabilizing the interaction of jun homodimers with target gene promoters.
10545	molecular chaperone that functions in the processing and transport of secreted proteins (by similarity).
10546	
10547	
10548	
10549	
10550	
10551	
10552	accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. alters functional properties of kv1.4.
10553	in the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (krtap), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. the matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
10554	
10555	binds to the caccc box in the beta-globin gene promoter and activates transcription (by similarity).
10556	transcriptional repressor.
10557	protein kinase that plays an important role in cellular stress response. activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic foxo3a. phosphorylates nedd4l, which leads to its inactivation and to the subsequent activation of various channels and transporters such as enac, kv1.3, or eaat1.
10558	destroys radicals which are normally produced within the cells and which are toxic to biological systems.
10559	probably methylates the guanidino nitrogens of arginyl residues in some proteins. may play a role in transcriptional coactivation.
10560	transcription factor that binds to and transactivates the tshb promoter. binds to a minimal dna-binding sequence 5@#$%&- [tc][ag][ag]tta[tc][ag]-3@#$%&.
10561	
10562	
10563	dna- and rna binding protein, involved in several nuclear processes. binds the conventional octamer sequence in double stranded dna. also binds single-stranded dna and rna at a site independent of the duplex site (by similarity). involved in pre-mrna splicing, probably as an heterodimer with sfpq. interacts with u5 snrna, probably by binding to a purine-rich sequence located on the 3@#$%& side of u5 snrna stem 1b. the sfpq-nono heteromer associated with matr3 may play a role in nuclear retention of defective rnas. the sfpq-nono heteromer may be involved in dna unwinding by modulating the function of topoisomerase i/top1. the sfpq-nono heteromer may be involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination and may stabilize paired dna ends. in vitro, the complex strongly stimulates dna end joining, binds directly to the dna substrates and cooperates with the ku70/g22p1-ku80/xrcc5 (ku) dimer to establish a functional preligation complex. nono is involved in transcriptional regulation. the sfpq-nono-nr5a1/sf-1 complex binds to the cyp17 promoter and regulates basal and camp-dependent transcriptional avtivity. nono binds to an enhancer element in long terminal repeats of endogenous intracisternal a particles (iaps) and activates transcription (by similarity).
10564	
10565	
10566	
10567	
10568	
10569	
10570	
10571	
10572	
10573	
10574	
10575	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. displays high levels of activity on medium- and long chain acyl coas.
10576	gtpase-activating protein for rac1 and cdc42. promotes the exchange of rac or cdc42-bound gdp by gtp, thereby activating them. displays serine/threonine kinase activity.
10577	
10578	
10579	
10580	
10581	
10582	
10583	
10584	
10585	
10586	
10587	works in concert with the 5alpha/5beta-steroid reductases to convert steroid hormones into the 3alpha/5alpha and 3alpha/5beta-tetrahydrosteroids. catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5alpha-dht) to 5-alpha-androstane-3alpha,17beta-diol (3-alpha-diol).
10588	
10589	
10590	
10591	
10592	
10593	
10594	
10595	
10596	
10597	
10598	
10599	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb (by similarity).
10600	
10601	
10602	
10603	essential for biological clock functions. determines the period length of circadian and ultradian rhythms; an increase in per dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. the biological cycle depends on the rhythmic formation and nuclear localization of the tim-per complex. light induces the degradation of tim, which promotes elimination of per. nuclear activity of the heterodimer coordinatively regulates per and tim transcription through a negative feedback loop. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition.
10604	component of the fact complex, a general chromatin factor that acts to reorganize nucleosomes. the fact complex is involved in multiple processes that require dna as a template such as mrna elongation, dna replication and dna repair. during transcription elongation the fact complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. it facilitates the passage of rna polymerase ii and transcription by promoting the dissociation of one histone h2a-h2b dimer from the nucleosome, then subsequently promotes the reestablishement of the nucleosome following the passage of rna polymerase ii. transcription elongation is promoted by the repression of transcription initiation from cryptic sites. also acts in establishing transcription initiation complexes and promotes spt15/tbp-binding to a tata box. together with replication factor-a protein (rpa), fact may play a role in nucleosome deposition during dna replication.
10605	gtp-binding protein with gtpase activity. elicits the formation of f-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (by similarity).
10606	promotes the exchange of cdc42-bound gdp by gtp. controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. cdc24 may be involved in the initial selection and organization of the budding site.
10607	
10608	
10609	
10610	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
10611	may mediate the control of various cellular processes by insulin.
10612	
10613	
10614	
10615	
10616	
10617	
10618	reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. involved in intracellular redox signaling.
10619	
10620	
10621	
10622	may act as a zinc-influx transporter.
10623	
10624	
10625	
10626	may be involved in transcriptional regulation.
10627	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
10628	
10629	potassium channel activated by both membrane depolarization or increase in cytosolic ca(2+) that mediates export of k(+). it is also activated by the concentration of cytosolic mg(2+). its activation dampens the excitatory events that elevate the cytosolic ca(2+) concentration and/or depolarize the cell membrane. it therefore contributes to repolarization of the membrane potential. plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. in smooth muscles, its activation by high level of ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. in cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. kinetics of kcnma1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. highly sensitive to both iberiotoxin (ibtx) and charybdotoxin (ctx).
10630	transcriptional activator which recognizes variations of the palindromic sequence 5@#$%&-attcccnngggaatt-3@#$%&.
10631	
10632	binds to activated (phosphorylated) protein-tyrosine kinases through its sh2 domain and regulates their kinase activity. during insulin stimulation, it also binds to irs-1.
10633	required only in the female germ line. it is important for oocyte formation and in the specification of the posterior structures of the embryo.
10634	
10635	
10636	
10637	serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as tnf-alpha. appears to act upstream of the jun n-terminal pathway.
10638	involved in the ubiquitination and subsequent proteasomal degradation via the von hippel-lindau ubiquitination complex. seems to act as target recruitment subunit in the e3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (hif) under normoxic conditions. involved in transcriptional repression through interaction with hif1a, hif1an and histone deacetylases.
10639	
10640	
10641	involved in mediating u snrna export from the nucleus. binds to 5@#$%& capped mrna.
10642	
10643	
10644	interacts with naf1 and inhibits tnf-induced nf-kappa-b- dependent gene expression by interfering with an rip- or traf2- mediated transactivation signal. inhibitor of programmed cell death. has a role in the function of the lymphoid system and may contribute to the in vivo effects of tnf (by similarity). has deubiquitinating activity that is directed towards lys-48 or lys- 63-linked polyubiquitin chains.
10645	
10646	
10647	
10648	
10649	
10650	
10651	
10652	involved in transport from the endoplasmic reticulum to the golgi apparatus (by similarity).
10653	
10654	involved in repair of uv radiation-induced dna damage. catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same dna strand upon exposure to ultraviolet radiation.
10655	
10656	activates cdc42, a member of the ras-like family of rho- and rac proteins, by exchanging bound gdp for free gtp. plays a role in regulating the actin cytoskeleton and cell shape.
10657	
10658	
10659	
10660	
10661	
10662	collagen type iii occurs in most soft connective tissues along with type i collagen.
10663	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&. activates transcription of pf4 in complex with meis1.
10664	may be involved in transcriptional regulation.
10665	
10666	may play a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. there are four molecules of fkbp12 per skeletal muscle ryr. ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
10667	
10668	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
10669	
10670	
10671	
10672	
10673	cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (by similarity).
10674	
10675	
10676	
10677	
10678	
10679	
10680	
10681	
10682	
10683	
10684	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. displays high levels of activity on medium- and long chain acyl coas.
10685	
10686	
10687	
10688	
10689	
10690	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
10691	
10692	
10693	
10694	
10695	
10696	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
10697	
10698	
10699	
10700	
10701	
10702	
10703	
10704	
10705	in vitro, acts as a receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5).
10706	
10707	
10708	
10709	
10710	
10711	
10712	
10713	
10714	involved in the presentation of foreign antigens to the immune system.
10715	
10716	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
10717	
10718	
10719	
10720	
10721	
10722	
10723	could have a regulatory function in meiosis.
10724	
10725	
10726	
10727	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. lamin a and c are present in equal amounts in the lamina of mammals.
10728	
10729	
10730	this is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
10731	
10732	
10733	
10734	
10735	
10736	
10737	
10738	has a transcriptional repressor activity by cooperating with epc1. induces apoptosis by activating jun n-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. may function in male germ cell development. has dna-binding activity and preferentially bound to double-stranded dna (by similarity).
10739	
10740	
10741	involved in vesicular protein trafficking.
10742	
10743	
10744	
10745	
10746	
10747	
10748	
10749	may have a role in the regulation of spermatogenesis.
10750	required for left-right (l-r) asymmetry determination of organ systems in mammals. may play a role in endometrial bleeding.
10751	
10752	intracellular transport of retinol.
10753	
10754	this is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
10755	receptor for udp-glucose and other udp-sugar coupled to g-proteins. not activated by atp, adp, utp or atp.
10756	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
10757	may function as a tumor suppressor, inhibiting colony formation, causing g1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
10758	rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. it may also have a role in the development of malignancy and the growth progression of some tumors.
10759	
10760	histone h4, along with histone h3, plays a central role in nucleosome formation.
10761	seems to play an important role in erythropoiesis.
10762	
10763	
10764	
10765	
10766	probably involved in the control of the cell cycle. interacts with d-type g1 cyclins.
10767	mediates the splicing of pre-mrna by binding to the stem loop i region of u1-snrna.
10768	
10769	putative atp-dependent protease.
10770	
10771	
10772	
10773	isoform gch-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.
10774	
10775	
10776	probable transcriptional regulator involved in developmental processes. could be required for specification of paraxial mesoderm structures during gastrulation (by similarity).
10777	
10778	involved in redox regulation of the cell. reduces peroxides with reducing equivalents provided through the thioredoxin system. it is not able to receive electrons from glutaredoxin. may play an important role in eliminating peroxides generated during metabolism. might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of h(2)o(2).
10779	produces atp from adp in the presence of a proton gradient across the membrane.
10780	cytochromes p450 are a group of heme-thiolate monooxygenases. this enzyme requires molecular oxygen and nadph for the omega-hydroxylation of ltb4, a potent chemoattractant for polymorphonuclear leukocytes.
10781	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
10782	
10783	
10784	dorsalizing factor. key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing tgf-beta family bone morphogenetic proteins (bmps) and sequestering them in latent complexes.
10785	stimulates specifically the gtpase activity of ypt6.
10786	
10787	
10788	binds preferentially single-stranded dna and unwinds double stranded dna.
10789	associates with the t-cell antigen receptor zeta chain (cd3z). plays a role in lymphocyte activation.
10790	
10791	
10792	
10793	
10794	
10795	
10796	
10797	involved in the presentation of foreign antigens to the immune system.
10798	
10799	tumor-associated antigen.
10800	
10801	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
10802	may play a role in the response to environmental stress. appears to act upstream of the jun n-terminal pathway.
10803	
10804	
10805	
10806	
10807	
10808	
10809	
10810	
10811	
10812	molecular chaperone. has atpase activity (by similarity).
10813	osteostatin is a potent inhibitor of osteoclastic bone resorption.
10814	
10815	
10816	
10817	has an atp-independent isopeptidase activity, cleaving at the c-terminus of the ubiquitin moiety. in vitro, isoform 2, but not isoform 3, shows deubiquitinating activity.
10818	receptor for grf, coupled to g proteins which activate adenylyl cyclase. stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.
10819	
10820	could function as a cell-adhesion protein. acts as a tumor suppressor. required for correct morphogenesis.
10821	
10822	
10823	dna-binding protein that binds to the 5@#$%&-aata[ct]-3@#$%& core sequence. probably acts as a transcription regulator. represses the cytomegalovirus enhancer. overexpression leads to induction of smooth muscle marker genes, suggesting that it may act as a regulator of smooth muscle cell differentiation and proliferation. may be involved in lipid stores.
10824	
10825	
10826	
10827	
10828	atp-dependent specificity component of the clp protease. it directs the protease to specific substrates. can perform chaperone functions in the absence of clpp (by similarity).
10829	
10830	
10831	
10832	
10833	
10834	
10835	
10836	major keratinocyte cell envelope protein.
10837	sequence-specific rna-binding protein that regulates translation and mrna stability by binding the 3@#$%& untranslated regions (utrs) of mrna targets. may be required to support proliferation and self-renewal of stem cells (by similarity).
10838	component of a putative tumor-recognition complex. involved in the function of nk cells.
10839	
10840	
10841	
10842	
10843	forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
10844	
10845	catalyzes the covalent attachment of ubiquitin to other proteins. in association with the e3 enzyme bre1 and lge1, it plays a role in transcription regulation by catalyzing the monoubiquitination of lys-123 of histone h2b leading to the trimethylation of histone h3 lys-4 by compass, the localization of the paf1 complex to the chromatin and the silencing of telomeric- associated genes. in association with the e3 enzyme rad18, it catalyzes the monoubiquitination of pol30 lys-164, involved in postreplication repair of uv-damaged dna. the ubc2-rad18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine. in association with the e3 enzyme ubr1, is involved in n-end rule-dependent protein degradation. also involved in sporulation.
10846	
10847	may be involved in transcriptional regulation.
10848	transcription factor that binds gc and gt boxes in the d1a, d2 and d3 dopamine receptor promoters and displaces sp1 and sp3 from these sequences. it modulates dopaminergic transmission in the brain by repressing or activating transcription from several different promoters depending on cellular context.
10849	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
10850	
10851	somewhat implicated in the biogenesis of peroxisomes.
10852	promotes the exchange of ras-bound gdp by gtp.
10853	
10854	binds the sequence 5@#$%&-atcaatcaa-3@#$%&. acts as a transcriptional activator of pf4 in complex with meis1. converted into a potent transcriptional activator by the (1;19) translocation. may have a role in steroidogenesis and, subsequently, sexual development and differentiation.
10855	
10856	
10857	
10858	
10859	
10860	inhibitor of protein-phosphatase 1.
10861	
10862	essential component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. seems to control the nucleotide-dependent binding of mitochondrial hsp70 to substrate proteins.
10863	recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. involved in the degradation of cyclin e, notch1 released notch intracellular domain (nicd), and probably psen1.
10864	
10865	sodium-ion dependent, high affinity carnitine transporter. involved in the active cellular uptake of carnitine. transports one sodium ion with one molecule of carnitine. also transports organic cations such as tetraethylammonium (tea) without the involvement of sodium. also relative uptake activity ratio of carnitine to tea is 11.3.
10866	
10867	involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. substrates include pomc, renin, enkephalin, dynorphin, somatostatin and insulin.
10868	
10869	contactins mediate cell surface interactions during nervous system development. has some neurite outgrowth-promoting activity (by similarity).
10870	
10871	histone h3, along with histone h4, plays a central role in nucleosome formation.
10872	
10873	redirects newly synthesized mhc class i heavy chains via the sec61 translocon to the cytosol where they undergo proteasome- dependent destruction. in consequence, infected cells are masked for immune recognition by cytotoxic t-lymphocytes.
10874	adf augments the expression of the interleukin-2 receptor tac (il2r/p55).
10875	binds medium- and long-chain acyl-coa esters with very high affinity and may function as an intracellular carrier of acyl-coa esters. it is also able to displace diazepam from the benzodiazepine (bzd) recognition site located on the gaba type a receptor. it is therefore possible that this protein also acts as a neuropeptide to modulate the action of the gaba receptor.
10876	
10877	
10878	
10879	functions in mitochondrial and peroxisomal division probably by regulating membrane fission. enzyme hydrolyzing gtp that oligomerizes to form ring-like structures and is able to remodel membranes. may also play a role on organelles of the secretory pathway.
10880	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
10881	required for membrane traffic to the vacuole.
10882	cooperates with cdc6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate dna replication. binds dna in a sequence-, strand-, and conformation-independent manner. potential oncogene.
10883	may be involved in transcriptional regulation.
10884	may be involved in transcriptional regulation.
10885	thiolesterase that catalyzes the hydrolysis of s-d- lactoyl-glutathione to form glutathione and d-lactic acid.
10886	
10887	
10888	
10889	
10890	may be involved in transcriptional regulation.
10891	udpgt is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. the major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (dht) > androstane-3alpha,17beta-diol (3alpha-diol) > testosterone > androsterone (adt).
10892	catalyzes the covalent attachment of ubiquitin to other proteins.
10893	
10894	stimulates specifically the gtpase activity of ypt6.
10895	
10896	required for intramitochondrial proteolysis. catalyzes the initial steps of protein degradation.
10897	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
10898	
10899	
10900	
10901	
10902	
10903	
10904	
10905	
10906	participates in the regulation of gene transcription. binds dna both in a non-specific manner and also specifically to recognizes the core sequence 5@#$%&-cac[ga]tg-3@#$%&. seems to activate the transcription of growth-related genes.
10907	involved in pre-mrna splicing. is required together with atp and at least one other factor, for the first cleavage-ligation reaction. interacts directly with the pre-mrna.
10908	
10909	
10910	
10911	
10912	binds pre-mrna and nucleates the assembly of 40s hnrnp particles. single hnrpc tetramers bind 230-240 nucleotides. trimers of hnrpc tetramers bind 700 nucleotides. may play a role in the early steps of spliceosome assembly and pre-mrna splicing. interacts with poly-u tracts in the 3@#$%& or 5@#$%& untranslated regions of mrna and modulates the stability and the level of translation of bound mrna molecules.
10913	
10914	subunit of atp-sensitive potassium channels (katp). can form cardiac and smooth muscle-type katp channels with kir6.2. kir6.2 forms the channel pore while sur2 is required for activation and regulation.
10915	
10916	
10917	
10918	
10919	
10920	
10921	
10922	
10923	
10924	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
10925	
10926	
10927	
10928	
10929	
10930	
10931	required for protein transport from the er to the golgi complex.
10932	
10933	
10934	involved in calcium binding and microtubule stabilization.
10935	may play a role in apoptosis by acting as a cell death substrate for caspases. is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. may be involved in the membrane ruffling process (by similarity).
10936	activates cdc42, a member of the ras-like family of rho- and rac proteins, by exchanging bound gdp for free gtp. plays a role in regulating the actin cytoskeleton and cell shape.
10937	
10938	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
10939	component of the cytoplasmic fibrils of the nuclear pore complex implicated in nuclear protein import. its n-terminus is involved in activation of oncogenic kinases.
10940	
10941	
10942	has acyl-coa ligase activity for long-chain and very- long-chain fatty acids. does not exhibit fatty acid transport activity (by similarity).
10943	this small ubiquitous enzyme is essential for maintenance and cell growth.
10944	stabilizer subunit of the dolichol-phosphate-mannose synthase complex.
10945	
10946	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes and then transfers it to substrates (by similarity).
10947	possible adhesion molecule with a role in early hematopoiesis by mediating attachment to stromal cells. influences the survival and/or proliferation of b-cell precursors. binding to cells requires mn(2+) (by similarity).
10948	udpgt is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
10949	promotes the exchange of ras-bound gdp by gtp.
10950	transcriptional activator. binds to fat body-specific enhancers of alcohol dehydrogenase (adh) and yolk protein genes. bbf-2 may play a role in fat body gene expression. it binds the consensus sequence 5@#$%&-t[ac]nacgtan[tg]c-3@#$%&.
10951	
10952	
10953	specifically hydroxylates an asp or asn residue in certain epidermal growth factor-like (egf) domains of a number of proteins.
10954	it may catalyze the formation of the neuac-alpha-2,3- gal-beta-1,3-galnac- or neuac-alpha-2,3-gal-beta-1,3-glcnac- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. it may be involved in the biosynthesis of the sialyl lewis x determinant.
10955	
10956	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
10957	
10958	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
10959	promotes guanine-nucleotide exchange on arf1 and arf5. promotes the activation of arf through replacement of gdp with gtp.
10960	may be involved in transcriptional regulation.
10961	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
10962	
10963	probably plays a role in facilitating the assembly of multimeric protein complexes inside the er.
10964	
10965	stimulates the dissociation of gdp from the ras-related rala and ralb gtpases which allows gtp binding and activation of the gtpases. interacts and acts as an effector molecule for r-ras, h-ras, k-ras, and rap.
10966	
10967	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
10968	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
10969	
10970	
10971	inhibits the binding of prostaglandin f2-alpha (pgf2- alpha) to its specific fp receptor, by decreasing the receptor number rather than the affinity constant. functional coupling with the prostaglandin f2-alpha receptor seems to occur.
10972	involved in the inactivation of map kinases. has a specificity for the mapk11/mapk12/mapk13/mapk14 subfamily.
10973	
10974	
10975	
10976	
10977	
10978	has chemotactic activity for neutrophils. may play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. in vitro, the processed form gro-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
10979	general transcription factor. btf3 can form a stable complex with rna polymerase ii. required for the initiation of transcription.
10980	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling. phosphorylates ctnnb1 on ser-45.
10981	pp2a can modulate the activity of phosphorylase b kinase casein kinase 2, mitogen-stimulated s6 kinase, and map-2 kinase. can dephosphorylate sv40 large t antigen and p53. dephosphorylates sv40 large t antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. the c subunit was most active, followed by the ac form, which was more active than the abc form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. dephosphorylation by the ac form, but not c or abc form is inhibited by small t antigen.
10982	may have an important role in regulating the access of circulating igfs to the tissues.
10983	responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain.
10984	
10985	jana and janb regulate somatic sex differentiation.
10986	
10987	
10988	
10989	
10990	
10991	cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
10992	transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. crucial in the maintenance of the thyroid differentiation phenotype. may play a role in lung development and surfactant homeostasis.
10993	could have a regulatory function in meiosis.
10994	
10995	
10996	
10997	
10998	
10999	
11000	
11001	
11002	required for vesicular transport between the endoplasmic reticulum and the golgi apparatus.
11003	transcription factor required for gene expression specific to photoreceptor cells.
11004	potent transcriptional repressor that binds to the h1 element of the ets2 promoter. may regulate other genes involved in cellular proliferation.
11005	
11006	
11007	not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
11008	
11009	
11010	may regulate the transcription of specific genes during normal development. may play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. implicated in the transduction of shh signal (by similarity).
11011	
11012	component of the anaphase promoting complex/cyclosome (apc/c), a cell cycle-regulated e3 ubiquitin ligase that controls progression through mitosis and the g1 phase of the cell cycle.
11013	
11014	probably involved in connections of major cytoskeletal structures to the plasma membrane.
11015	
11016	
11017	
11018	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
11019	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
11020	
11021	
11022	
11023	
11024	
11025	
11026	
11027	
11028	
11029	
11030	
11031	
11032	could function as a cell-adhesion protein. acts as a tumor suppressor. required for correct morphogenesis.
11033	
11034	
11035	
11036	
11037	
11038	
11039	appears to play a role in cell sterol metabolism. it may function to protect cells from over-accumulation of cholesterol.
11040	
11041	necessary for efficient rna polymerase ii transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by s-ii allows the resumption of elongation from the new 3@#$%&terminus.
11042	
11043	
11044	
11045	the major proteolytic product p15 bid allows the release of cytochrome c (by similarity). isoform 1, isoform 2 and isoform 4 induce ice-like proteases and apoptosis. isoform 3 does not induce apoptosis. counters the protective effect of bcl-2.
11046	
11047	may play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.
11048	
11049	
11050	
11051	
11052	
11053	deubiquitinating enzyme.
11054	protection of cells from complement-mediated damage (by similarity).
11055	protein tyrosine phosphatase which stimulates progression from g1 into s phase during mitosis. promotes tumors. inhibits geranylgeranyl transferase type ii activity by blocking the association between rabggta and rabggtb.
11056	
11057	
11058	associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. it may function in the assembly and/or transport of ribosome.
11059	
11060	has greatest activity toward short branched chain acyl- coa derivative such as (s)-2-methylbutyryl-coa, isobutyryl-coa, and 2-methylhexanoyl-coa as well as toward short straight chain acyl-coas such as butyryl-coa and hexanoyl-coa. can use valproyl- coa as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent.
11061	
11062	
11063	
11064	acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin g. may prevent elastase-mediated damage to oral and possibly other mucosal tissues.
11065	probably involved in the organization of the actin cytoskeleton. may act downstream of cdc42 to induce actin filament assembly leading to cell shape changes. induces pseudopodia formation, when overexpressed in fibroblasts.
11066	
11067	
11068	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking among different compartments. modulates vesicle budding and uncoating within the golgi complex. deactivation induces the redistribution of the entire golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. in its gtp-bound form, its triggers the association with coat proteins with the golgi membrane. the hydrolysis of arf1-bound gtp, which is mediated by arfgaps proteins, is required for dissociation of coat proteins from golgi membranes and vesicles.
11069	required maternally for proper expression of other homeotic genes involved in pattern formation, such as ubx.
11070	may modulate calcium-mediated postsynaptic signals (by similarity).
11071	
11072	transporter for alanine, serine, cysteine, and threonine. exhibits sodium dependence.
11073	regulatory light chain of myosin. does not bind calcium.
11074	acts as a transcriptional repressor for zinc finger transcription factors egr1 and egr2 (by similarity).
11075	
11076	required for protein transport from the er to the golgi complex.
11077	
11078	
11079	
11080	required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.
11081	involved in the maintenance of proper dna topology and chromosome integrity via annealing of single-stranded dna breaks. modulates dna polymerase delta during replication or replication- associated repair. may function as a modulator for sgs1 when dna is damaged.
11082	may be involved in transcriptional regulation.
11083	
11084	
11085	
11086	
11087	binds the telomeric double-stranded ttaggg repeat and negatively regulates telomere length. involved in the regulation of the mitotic spindle.
11088	acts as decoy receptor for rankl and thereby neutralizes its function in osteoclastogenesis. inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. bone homeostasis seems to depend on the local rankl/opg ratio. may also play a role in preventing arterial calcification. may act as decoy receptor for trail and protect against apoptosis. trail binding blocks the inhibition of osteoclastogenesis.
11089	
11090	
11091	
11092	
11093	
11094	
11095	membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. it plays a role in fatty-acid desaturation and is also involved in several steps of the sterol biosynthesis pathway, particularly in the 4- demethylation of the 4,4@#$%&-dimethyl zymosterol.
11096	essential for the control of the cell cycle at the g1/s (start) transition.
11097	receptor for mica, micb, ulbp1, ulbp2, ulbp3 (ulbp2>ulbp1>ulbp3) and ulbp4. plays a role as a receptor for the recognition of mhc class i hla-e molecules by nk cells and some cytotoxic t-cells. involved in the immune surveillance exerted by t- and b-lymphocytes.
11098	
11099	
11100	
11101	
11102	
11103	
11104	
11105	involved in the biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (moad).
11106	required for membrane traffic to the vacuole.
11107	
11108	involved in maintaining the transcriptionally repressive state of genes. modifies chromatin, rendering it heritably changed in its expressibility (by similarity). regulator of cellular lifespan by maintaining the repression of cdkn2a, but not by inducing telomerase activity.
11109	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
11110	
11111	
11112	molecular chaperone. has atpase activity (by similarity).
11113	
11114	
11115	
11116	
11117	isoform b has an accelerated gef-independent gdp/gtp exchange and an impaired gtp hydrolysis, which is restored partially by gtpase-activating proteins. it is able to bind to the gtpase-binding domain of pak but not full-length pak in a gtp- dependent manner, suggesting that the insertion does not completely abolish effector interaction.
11118	
11119	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein (by similarity).
11120	
11121	
11122	
11123	
11124	transcriptional repressor.
11125	
11126	
11127	
11128	
11129	
11130	
11131	
11132	
11133	may act as a mediator of stress-activated signals.
11134	
11135	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
11136	
11137	
11138	
11139	
11140	
11141	
11142	
11143	
11144	
11145	
11146	
11147	
11148	
11149	
11150	may be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors (potential).
11151	regulates myosin phosphatase activity. augments ca(2+) sensitivity of the contractile apparatus.
11152	
11153	
11154	
11155	plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine.
11156	plays a role in photoreceptor morphogenesis in the retina. may maintain cell polarization and adhesion.
11157	may be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium atpase.
11158	
11159	can degrade casein. could play a role in tissues homeostasis and repair.
11160	
11161	
11162	inhibits nf-kappa-b activation. may participate in a regulatory mechanism that coordinates cellular responses controlled by nf-kappa-b transcription factor. may be a component of the inflammasome, a protein complex which also includes pycard, nalp2 and casp1 and whose function would be the activation of proinflammatory caspases.
11163	
11164	
11165	
11166	necessary for early peroxisomal biogenesis. acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (pmps). binds and stabilizes newly synthesized pmps in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein pex3. excludes cdkn2a from the nucleus and prevents its interaction with mdm2, which results in active degradation of tp53.
11167	plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. this phosphodiesterase has high affinity for camp and may be involved in specific signaling in the thyroid gland.
11168	inhibits the transcriptional activity of spi1 in a dose- dependent manner (by similarity).
11169	
11170	
11171	may play an important role during the embryonic development and differentiation of the central nervous system.
11172	
11173	
11174	transcription regulator that acts as a key regulator of lineage commitment of immature t-cell precursors. necessary and sufficient for commitment of cd4 lineage, while its absence causes cd8 commitment. development of immature t-cell precursors (thymocytes) to either the cd4 helper or cd8 killer t-cell lineages correlates precisely with their t-cell receptor specificity for major histocompatibility complex class ii or class i molecules, respectively. transcriptional repressor of the collagen col1a1 and col1a2 genes. may also function as a repressor of fibronectin and possibly other extracellular matrix genes (by similarity).
11175	not known. may be involved in the synthesis of the sugar donor dol-p-man which is required in the synthesis of n-linked and o-linked oligosaccharides and for that of gpi anchors (by similarity).
11176	
11177	e3 ubiquitin ligase protein that mediates monoubiquitination of lys-119 of histone h2a, thereby playing a central role in histone code and gene regulation. h2a lys-119 ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in x chromosome inactivation of female mammals. may be involved in the initiation of both imprinted and random x inactivation. essential component of the polycomb group (pcg) multiprotein prc1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including hox genes, throughout development. pcg prc1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. acts as the main e3 ubiquitin ligase on histone h2a of the prc1 complex, while ring1 and pcgf4/bmi1 may rather act as a modulator of rnf2/ring2 activity.
11178	associates with cd4 or cd8 and delivers costimulatory signals for the tcr/cd3 pathway.
11179	important for the overall degradation of proteins in lysosomes. essential for adult male and female fertility. may play a role in digestion.
11180	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
11181	receptor for interleukin-1 alpha (il-1a), beta (il-1b), and interleukin-1 receptor antagonist protein (il-1ra). binding to the agonist leads to the activation of nf-kappa-b. signaling involves formation of a ternary complex containing il1rap, tollip, myd88, and irak1 or irak2.
11182	
11183	sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate (by similarity).
11184	
11185	
11186	catalyzes the covalent attachment of ubiquitin to other proteins. required for postreplication repair of uv-damaged dna. may be involved in neurite outgrowth.
11187	constitutes one of the e3 ubiquitin ligase proteins that mediate monoubiquitination of lys-119 of histone h2a, thereby playing a central role in histone code and gene regulation. h2a lys-119 ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in x chromosome inactivation of female mammals. essential component of the polycomb group (pcg) multiprotein prc1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including hox genes, throughout development. pcg prc1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. compared to rnf2/ring2, it does not have the main e3 ubiquitin ligase activity on histone h2a, and it may rather act as a modulator of rnf2/ring2 activity.
11188	
11189	
11190	
11191	
11192	interacts with the viral protein-binding domain of the retinoblastoma protein.
11193	plays a role in tight junctions and adherens junctions.
11194	may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with gtp-binding proteins. essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. can interact with syntaxins 1, 2, and 3 but not syntaxin 4. may play a role in determining the specificity of intracellular fusion reactions.
11195	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
11196	
11197	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. utilizes a wide range of saturated fatty acids with a preference for c16-c18 unsaturated fatty acids (by similarity).
11198	
11199	
11200	links t-cell receptor activation signal to phospholipase c-gamma-1, grb-2 and phosphatidylinositol 3-kinase (by similarity).
11201	
11202	tfiia is a component of the transcription machinery of rna polymerase ii and plays an important role in transcriptional activation. interacts with tbp (the tata-binding protein).
11203	receptor for extracellular adenine nucleotides such as atp and adp. in pancreatic islets, may mediate some of the effects of extracellular atp on insulin secretion.
11204	
11205	
11206	
11207	
11208	
11209	transcriptional modulator activated by tgf-beta and activin type 1 receptor kinase. smad2 is a receptor-regulated smad (r-smad). may act as a tumor suppressor in colorectal carcinoma.
11210	
11211	
11212	
11213	subunit of the splicing factor sf3a required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex.
11214	
11215	
11216	has a beta1,3-n-acetylglucosaminyltransferase activity for type 2 oligosaccharides.
11217	may play a role in neural crest cell migration into the third and fourth pharyngeal pouches.
11218	dephosphorylates proteins phosphorylated on ser, thr, and tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate.
11219	receptor for interleukin-2. this beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of il2.
11220	
11221	inhibitor of the slam self-association. acts by blocking recruitment of the sh2-domain-containing signal-transduction molecule shp-2 to a docking site in the slam cytoplasmic region.
11222	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
11223	
11224	
11225	
11226	probable dna-repair protein.
11227	
11228	required for protein transport from the er to the golgi complex.
11229	
11230	plays a major role in ketone body metabolism.
11231	type i collagen is a member of group i collagen (fibrillar forming collagen).
11232	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
11233	
11234	transports l-glutamate; the l-glutamate uptake is sodium- and voltage-dependent and chloride-independent. the eaat5- associated chloride conductance may participate in visual processing.
11235	
11236	
11237	
11238	
11239	endostatin potently inhibits endothelial cell proliferation and angiogenesis. may inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
11240	
11241	transcriptional regulator involved in development.
11242	
11243	
11244	
11245	
11246	
11247	
11248	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
11249	
11250	
11251	
11252	
11253	
11254	
11255	
11256	
11257	
11258	
11259	
11260	
11261	
11262	
11263	
11264	
11265	
11266	
11267	
11268	transcriptional repressor that binds to the promoter region of target genes. plays a role in the regulation of the cell cycle and of the wnt pathway. binds preferentially to the sequence 5@#$%&-ttcattcattca-3@#$%&. binding to the h1f0 promoter is enhanced by interaction with rb1. disrupts the interaction between dna and tcf4.
11269	non-catalytic subunit of the trna-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-trna. it cleaves pre-trna at the 5@#$%& and 3@#$%& splice sites to release the intron. the products are an intron and two trna half-molecules bearing 2@#$%&,3@#$%& cyclic phosphate and 5@#$%&-oh termini. there are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the trna body. the trna splicing endonuclease is also involved in mrna processing via its association with pre-mrna 3@#$%& end processing factors, establishing a link between pre-trna splicing and pre-mrna 3@#$%& end formation, suggesting that the endonuclease subunits function in multiple rna-processing events.
11270	may be involved in transcriptional regulation.
11271	may be involved in transcriptional regulation.
11272	
11273	
11274	
11275	
11276	
11277	
11278	
11279	may constitute a novel regulatory system for basal transcription. negatively regulates abt1 (by similarity).
11280	
11281	
11282	may have an important role in presynaptic function. may be involved in calcium-dependent neurotransmitter release at nerve endings (by similarity).
11283	
11284	
11285	
11286	may be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.
11287	
11288	
11289	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
11290	chemotactic for interleukin-activated t-cells but not unstimulated t-cells, neutrophils or monocytes. induces calcium release in activated t-cells. binds to cxcr3. may play an important role in cns diseases which involve t-cell recruitment. may play a role in skin immune responses.
11291	regulatory subunit of the calcium activated potassium kcnma1 (maxik) channel. modulates the calcium sensitivity and gating kinetics of kcnma1, thereby contributing to kcnma1 channel diversity. increases the apparent ca(2+)/voltage sensitivity of the kcnma1 channel. it also modifies kcnma1 channel kinetics and alters its pharmacological properties. it slows down the activation and the deactivation kinetics of the channel. acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to kcnma1. its presence is also a requirement for internal binding of the kcnma1 channel opener dehydrosoyasaponin i (dhs-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (e2). increases the binding activity of charybdotoxin (ctx) toxin to kcnma1 peptide blocker by increasing the ctx association rate and decreasing the dissociation rate.
11292	segment polarity protein, functions together with arm to transduce the wingless (wg) signal. acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
11293	fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
11294	has a high affinity for both camp and cgmp.
11295	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna.
11296	synthesis and degradation of fructose 2,6-bisphosphate.
11297	receptor for acidic and basic fibroblast growth factors.
11298	binds mannose and n-acetylglucosamine in a calcium- dependent manner. is capable of host defense against pathogens, by activating the classical complement pathway independently of the antibody.
11299	may contribute to the transparency and refractive index of the lens.
11300	
11301	may mediate the control of various cellular processes by insulin.
11302	probable transcription factor. may play an important role in recruitment of elf4 into pml nuclear bodies.
11303	
11304	
11305	
11306	
11307	
11308	
11309	binds to the 23s rrna (by similarity).
11310	precursors of the cornified envelope of the stratum corneum.
11311	likely to be an important mediator of ventricular differentiation during cardiac development.
11312	
11313	type i collagen is a member of group i collagen (fibrillar forming collagen).
11314	
11315	
11316	
11317	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters.
11318	receptor for interleukin 18 (il-18). binding to the agonist leads to the activation of nf-kappa-b.
11319	cellular role is not yet known.
11320	
11321	
11322	may contribute to the alteration of neural cellular mechanisms (by similarity).
11323	
11324	involved in controlling the equilibrium between tubular and stacked structures in the golgi complex (by similarity). co- repressor targeting diverse transcription regulators. has dehydrogenase activity.
11325	not known, the c-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.
11326	
11327	
11328	
11329	
11330	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
11331	
11332	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
11333	sequence-specific dna-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. ap-2 factors bind to the consensus sequence 5@#$%&-gccnnnggc-3@#$%& and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. they also suppress a number of genes including mcam/muc18, c/ebp alpha and myc. ap-2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
11334	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
11335	
11336	transport of phosphorylated lysosomal enzymes from the golgi complex and the cell surface to lysosomes. lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low ph mediates the dissociation of the complex.
11337	in the intracellular compartments, may function as a channel or small molecule transporter.
11338	transcription factor that binds to gc box promoter elements. activates the transcription of these genes.
11339	
11340	
11341	
11342	
11343	receptor for tnfsf11/rankl/trance/opgl; essential for rankl-mediated osteoclastogenesis. involved in the regulation of interactions between t-cells and dendritic cells.
11344	component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity.
11345	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
11346	
11347	
11348	collagen type iv is specific for basement membranes. vital for embryonic development.
11349	orphan receptor.
11350	
11351	a metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. may also play a role in the metabolism of the vasodilator bradykinin.
11352	
11353	implicated in brca1-mediated tumor suppression. may, as part of the rna polymerase-2 holoenzyme, function in the cellular response to dna damage. in vitro, inhibits pre-mrna 3@#$%& cleavage.
11354	tumor suppressor. it blocks the growth, invasion, and metastatic properties of mammary tumors. as it does not undergo the s (stressed) to r (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
11355	
11356	
11357	
11358	
11359	
11360	
11361	
11362	
11363	protein transport. probably involved with ras-related protein rab-3a in synaptic vesicle traffic and/or synaptic vesicle fusion. could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
11364	may be involved in transcriptional regulation.
11365	
11366	
11367	
11368	
11369	
11370	
11371	
11372	
11373	
11374	
11375	
11376	
11377	
11378	
11379	exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper b into subunit i (by similarity).
11380	
11381	
11382	
11383	
11384	
11385	
11386	
11387	
11388	
11389	
11390	
11391	
11392	
11393	
11394	
11395	
11396	
11397	this multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. at the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. may therefore cause structural modifications of exofacial proteins. inside the cell, seems to form/rearrange disulfide bonds of nacent proteins. at high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. at low concentrations, facilitates aggregation (antichaperone activity). may be involved with other chaperones in the structural modification of the tg precursor in hormone biogenesis. also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein mttp.
11398	
11399	
11400	component of the circadian clock or downstream effector of clock function. exhibits a high amplitude circadian rhythm with maximal levels in early evening. in constant darkness or constant light, the amplitude of the rhythm decreases (by similarity).
11401	appears to mediate interactions between cells and the extracellular matrix. substrate-adhesion molecule that appears to inhibit cell migration. may play a role in supporting the growth of epithelial tumors.
11402	
11403	
11404	cd2 interacts with lymphocyte function-associated antigen (lfa-3) and cd48/bcm1 to mediate adhesion between t-cells and other cell types. cd2 is implicated in the triggering of t- cells, the cytoplasmic domain is implicated in the signaling function.
11405	
11406	
11407	binds to both dna and rna in vitro, with a stronger binding capacity for rna. may represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (by similarity).
11408	may be involved in protein transport (by similarity).
11409	it has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1. it is essential for growth or germination at 37 degrees celsius. may have a role in the heat shock response. involved in trna splicing and cell separation.
11410	
11411	receptor for glucocorticoids (gc). has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (gre) and as a modulator of other transcription factors. affects inflammatory responses, cellular proliferation and differentiation in target tissues. could act as a coactivator for stat5-dependent transcription upon growth hormone (gh) stimulation and could reveal an essential role of hepatic gr in the control of body growth.
11412	transcription factor that binds to the octamer motif (5@#$%&-atttgcat-3@#$%&). prime candidate for an early developmental control gene.
11413	
11414	may be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. acts as a transcription activator/factor. could maintain the noradrenergic phenotype.
11415	
11416	
11417	
11418	
11419	
11420	
11421	may play a role in the molecular organization of synapses and neuronal cell signaling. could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. may induce enrichment of psd-95/sap90 at the plasma membrane.
11422	as an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
11423	
11424	
11425	catalyzes the formation of fatty acid-cholesterol esters. plays a role in lipoprotein assembly and dietary cholesterol absorption. in addition to its acyltransferase activity, it may act as a ligase.
11426	central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. together with tom22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the tom40 translocation pore (by similarity).
11427	
11428	
11429	
11430	involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). may function as an activator of slc7a9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule.
11431	
11432	
11433	
11434	may be a mediator of localized cell proliferation. as a mitogen it may stimulate cell proliferation and/or angiogenesis.
11435	receptor for endothelin-1. mediates its action by association with g proteins that activate a phosphatidylinositol- calcium second messenger system. the rank order of binding affinities for et-a is: et1 > et2 >> et3.
11436	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
11437	
11438	
11439	
11440	may participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. may control the properties of the membrane associated cytoskeleton.
11441	may be involved in transcriptional regulation.
11442	
11443	receptor for the cytotoxic ligand tnfsf10/trail. the adapter molecule fadd recruits caspase-8 to the activated receptor. the resulting death-inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. promotes the activation of nf- kappa-b.
11444	
11445	stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. active in the presence of nad as cofactor but not in the presence of nadp.
11446	
11447	required for the binding of mrna to ribosomes. functions in close association with eif4-f and eif4-a. binds near the 5@#$%&- terminal cap of mrna in presence of eif-4f and atp. promotes the atpase activity and the atp-dependent rna unwinding activity of both eif4-a and eif4-f.
11448	
11449	component of the exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature nuclear complex. also associated with the gtpase ran. has a 3@#$%&-5@#$%& exonuclease activity.
11450	
11451	
11452	deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. also phosphorylates anti-viral and anti-cancer nucleoside analogs.
11453	
11454	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
11455	activates erythroid-specific, globin gene expression.
11456	calmodulin mediates the control of a large number of enzymes and other proteins by ca(2+). among the enzymes to be stimulated by the calmodulin-ca(2+) complex are a number of protein kinases and phosphatases.
11457	
11458	
11459	
11460	may be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. may play a role in cell migration.
11461	probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. may act by preventing binding of positively-activing ccaat factors to promoters. plays an essential role in lung maturation (by similarity).
11462	may participate in the obstruction of fluid outflow in the trabecular meshwork.
11463	also acts as a tumor suppressor.
11464	
11465	
11466	
11467	
11468	works in concert with the 5alpha/5beta-steroid reductases to convert steroid hormones into the 3alpha/5alpha and 3alpha/5beta-tetrahydrosteroids. catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5alpha-dht) to 5-alpha-androstane-3alpha,17beta-diol (3-alpha-diol).
11469	
11470	required for protein transport from the er to the golgi complex.
11471	
11472	
11473	may play a role in a erbb3-regulated signal transduction pathway. seems be involved in growth regulation. acts a corepressor of the androgen receptor (ar) and is regulated by the erbb3 ligand neuregulin-1/heregulin (hrg). inhibits transcription of some e2f1-regulated promoters, probably by recruiting histone acetylase (hat) activity. binds rna. associates with 28s, 18s and 5.8s mature rrnas, several rrna precursors and probably u3 small nucleolar rna. may be involved in regulation of intermediate and late steps of rrna processing. may be involved in ribosome assembly (by similarity). mediates cap-independent translation of specific viral iress (internal ribosomal entry site). together with ptbp1 is required for the translation initiation on the foot- and-mouth disease virus (fmdv) ires.
11474	probable transporter. the nucleotide-binding fold acts as an atp-binding subunit with atpase activity.
11475	
11476	
11477	
11478	
11479	the intermediate chains seem to help dynein bind to dynactin 150 kda component. may play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
11480	may be involved in transcriptional regulation.
11481	
11482	
11483	
11484	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
11485	
11486	
11487	
11488	
11489	mitochondrial rhomboid serine protease processing the mitochondrial membrane fusion regulator mgm1, and the cytochrome c peroxidase (ccp1). required for tim11 stability, atp synthase complex assembly, mitochondrial morphology, cytochrome c (cyc1) storage and mitochondrial genome maintenance.
11490	catalyzes the conversion of pgh2 to pgd2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. involved in a variety of cns functions, such as sedation, nrem sleep and pge2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. it is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
11491	
11492	component of the 60-80s u3 small nucleolar ribonucleoprotein (u3 snornp). required for the early cleavages during pre-18s ribosomal rna processing.
11493	
11494	
11495	
11496	
11497	
11498	plays an adhesive role by integrating collagen bundles. it is probably associated with the surface of interstitial collagen fibrils via col1. the col2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large n-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (by similarity).
11499	phosphorylates and activates not only pkb/akt, but also pka, pkc-zeta, p70s6k and p90s6k/rsk. may play a general role in signaling processes and in development (by similarity). isoform 3 is catalytically inactive.
11500	c1q associates with the proenzymes c1r and c1s to yield c1, the first component of the serum complement system. the collagen-like regions of c1q interact with the ca(2+)-dependent c1r(2)c1s(2) proenzyme complex, and efficient activation of c1 takes place on interaction of the globular heads of c1q with the fc regions of igg or igm antibody present in immune complexes.
11501	rna-binding protein that binds to several small cytoplasmic rna molecules known as y rnas. may stabilize these rnas from degradation.
11502	inhibitor of the caspase-activated dnase (dff40).
11503	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
11504	required for pre-mrna splicing. can also modulate alternative splicing in vitro.
11505	possible cell adhesion receptor. it possesses an intrinsic protein tyrosine phosphatase activity (ptpase). it controls motor axon guidance.
11506	
11507	ppiases accelerate the folding of proteins during protein synthesis.
11508	
11509	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
11510	promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. the c-terminus binds axonal microtubules while the n- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. the short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
11511	may have a role in spermatogenesis (by similarity).
11512	catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands.
11513	
11514	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
11515	inhibitor of the wnt signaling pathway. down-regulates beta-catenin. probably facilitate the phosphorylation of beta- catenin and apc by gsk3b (by similarity).
11516	glycosyltransferase involved in the elongation of o- linked ligands to activate notch signaling. possesses fucose- specific beta-1,3-n-acetylglucosaminyltransferase activity.
11517	
11518	
11519	
11520	could play a role in neuronal development.
11521	implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2a, regulation of mrna trafficking and stability in association with elavl1, and inhibition of acetyltransferases as part of the inhat (inhibitor of histone acetyltransferases) complex (by similarity).
11522	straight-chain enoyl-coa thioesters from c4 up to at least c16 are processed, although with decreasing catalytic rate.
11523	
11524	
11525	may mediate the control of various cellular processes by insulin. when phosphorylated by the insulin receptor binds specifically to various cellular proteins containing sh2 domains such as phosphatidylinositol 3-kinase p85 subunit or grb2. activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (by similarity).
11526	
11527	receptor for extracellular adenine nucleotides such as atp and adp. in platelets binding to adp leads to mobilization of intracellular calcium ions via activation of phospholipase c, a change in platelet shape, and probably to platelet aggregation.
11528	
11529	forms part of the dystrophin-associated protein complex (dapc) which may link the cytoskeleton to the extracellular matrix. alpha-dystroglycan functions as a laminin receptor. binds to several types of arenaviruses. is a target for the entry of mycobacterium leprae into peripheral nerve schwann cells.
11530	converts monoacylglycerides to free fatty acids and glycerol. hydrolyzes 2-arachidonoylglycerol, a putative endocannabinoid (by similarity).
11531	
11532	
11533	
11534	
11535	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
11536	
11537	
11538	the 26s protease is involved in the atp-dependent degradation of ubiquitinated proteins. the regulatory (or atpase) complex confers atp dependency and substrate specificity to the 26s complex. interacts with the orphan nuclear hormone receptor mb67.
11539	
11540	
11541	
11542	may play a role in normal anterior-chamber and lens development.
11543	
11544	
11545	
11546	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
11547	
11548	acts on epoxides (alkene oxides, oxiranes) and arene oxides. plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. also determines steady-state levels of physiological mediators. has phosphatase activity (by similarity).
11549	
11550	
11551	receptor for progesterone (by similarity). may be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) immunotoxicity.
11552	chemotactic for lymphocytes and monocytes. is a ligand for ccr1, ccr3 and ccr5. is an inhibitor of hiv-1-infection. the processed form ld78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is very potent inhibitor of hiv-1- infection. ld78-beta(3-70) is also a ligand for ccr1, ccr3 and ccr5.
11553	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
11554	
11555	receptor for trypsin and trypsin-like enzymes coupled to g proteins that stimulate phosphoinositide hydrolysis.
11556	
11557	
11558	
11559	plasma membrane-associated small gtpase which cycles between an active gtp-bound and inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. seems to be involved in the regulation of the nadph oxidase.
11560	
11561	involved in postreplication repair of uv-damaged dna. postreplication repair functions in gap-filling of a daughter strand on replication of damaged dna (potential).
11562	
11563	receptor for glutamate. l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists.
11564	
11565	
11566	
11567	
11568	
11569	
11570	
11571	
11572	
11573	
11574	
11575	
11576	
11577	
11578	
11579	
11580	
11581	
11582	
11583	
11584	
11585	
11586	
11587	
11588	
11589	
11590	may mediate a process in spermatogenesis or may play a role in sex ratio distortion.
11591	
11592	
11593	
11594	
11595	
11596	
11597	
11598	favors the reduction of estrogens and androgens. also has 20-alpha-hsd activity. uses preferentially nadh.
11599	
11600	
11601	plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations (by similarity).
11602	
11603	
11604	transcriptional repressor of a number of genes including sp1 target genes.
11605	
11606	
11607	required for protein transport from the er to the golgi complex.
11608	
11609	receptor for obesity factor (leptin). on ligand binding, mediates signaling through jak2/stat3. involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. may play a role in reproduction. can also mediate the erk/fos signaling pathway (by similarity).
11610	binds specifically to peptidoglycan and is involved in innate immunity. function in intracellular killing of bacteria. the soluble form triggers apoptosis in vitro.
11611	
11612	
11613	
11614	
11615	appears to function in the signal transduction from ras activation to actin cytoskeletal remodelling. suppresses insulin- induced promoter activities through ap1 and sre. mediates rap1- induced adhesion.
11616	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
11617	
11618	
11619	function in general translation initiation by promoting the binding of the formylmethionine-trna to ribosomes. seems to function along with eif-2.
11620	
11621	this gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
11622	
11623	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
11624	may play a role in signal transduction cascades in terminally differentiated cells.
11625	
11626	
11627	
11628	
11629	
11630	
11631	
11632	
11633	
11634	provides the precursors necessary for dna synthesis. catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
11635	
11636	type i collagen is a member of group i collagen (fibrillar forming collagen).
11637	probably involved in a neuron-specific signal transduction.
11638	
11639	
11640	
11641	
11642	
11643	
11644	
11645	
11646	
11647	
11648	
11649	may be involved in the regulation of specific developmental processes in the cns.
11650	plays a functional role in insulin and igf-i signaling. may serve to positively link the insulin and igf-i receptors to an uncharacterized mitogenic signaling pathway. interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. the interaction is mediated by the sh2 domain. also binds activated platelet-derived growth factor receptor and epidermal growth factor receptor.
11651	
11652	forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (by similarity).
11653	receptor-activated non-selective cation channel involved in detection of sensations such as cold, pain or sounds perception. involved in cold nociception by being activated by cold temperature below 17 degrees celsius, which is close to the noxious cold threshold. not involved in menthol sensation. also involved in pain sensation triggered by mustard oil or capsaicin, the pungent ingredient in chilli peppers, by being activated by these products. also acts as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (thc), the psychoactive component of marijuana. may be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. probably operated by a phosphatidylinositol second messenger system (by similarity).
11654	camp-dependent and sulfonylurea-sensitive anion transporter. key gatekeeper influencing intracellular cholesterol transport.
11655	
11656	
11657	
11658	has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (cns) neurons. binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (by similarity).
11659	
11660	transfers a sulfuryl group to an n-unsubstituted glucosamine linked to a 2-o-sulfo iduronic acid unit on heparan sulfate. catalyzes the o-sulfation of glucosamine in idoua2s-glcns and also in idoua2s-glcnh2. the substrate-specific o-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to herpes simplex virus-1 (hsv-1) and permits its entry. unlike 3-ost-1, does not convert nonanticoagulant heparan sulfate to anticoagulant heparan sulfate.
11661	may act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking (by similarity).
11662	may be involved in spermatogenesis.
11663	
11664	
11665	
11666	
11667	protein transport. probably involved in regulated exocytosis (by similarity).
11668	cytokine that binds to tnfrsf3/ltbr. binding to the decoy receptor tnfrsf6b modulates its effects. activates nfkb, stimulates the proliferation of t-cells, and inhibits growth of the adenocarcinoma ht-29. acts as a receptor for herpes simplex virus.
11669	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
11670	transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. potential role in g2/m cell cycle regulation (by similarity).
11671	phosphorylates microtubule-associated protein 2 (map2). myelin basic protein (mbp), and elk-1; may promote entry in the cell cycle.
11672	
11673	seems to be required for maximal rate of protein biosynthesis. enhances ribosome dissociation into subunits and stabilizes the binding of the initiator met-trna(i) to 40 s ribosomal subunits.
11674	
11675	may function as a signaling adapter protein in lymphocytes (by similarity).
11676	seems to be required for maximal rate of protein biosynthesis. enhances ribosome dissociation into subunits and stabilizes the binding of the initiator met-trna(i) to 40 s ribosomal subunits.
11677	
11678	serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors creb (camp response element-binding protein) and atf1 (activating transcription factor-1). essential role in the control of rela transcriptional activity in response to tnf. directly represses transcription via phosphorylation of ser-1 of histone h2a. mediates the mitogen- and stress-induced phosphorylation of histone h3 and high mobility group protein 14 (hmg-14).
11679	
11680	
11681	
11682	may function as a transcription factor.
11683	
11684	
11685	
11686	
11687	
11688	may be an ion-channel regulator. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis. involved in adhesive protein-protein and protein-carbohydrate interactions.
11689	
11690	
11691	could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. pro-apoptotic protein that functions intracellularly upstream of jnk activation and cytochrome c release.
11692	
11693	
11694	
11695	
11696	
11697	may be involved in transcriptional regulation.
11698	
11699	
11700	
11701	
11702	
11703	
11704	
11705	
11706	
11707	atp-dependent rna helicase (potential).
11708	
11709	
11710	
11711	
11712	
11713	
11714	
11715	
11716	
11717	adapter protein, which negatively regulates t-cell receptor (tcr) signaling. inhibits t-cell antigen-receptor induced activation of nuclear factor of activated t-cells. involved in the negative regulation of positive selection and mitosis of t-cells. may act by linking signaling proteins such as zap70 with cbl, leading to a cbl dependent degradation of signaling proteins.
11718	involved in the regulation of growth and apoptosis. mediates activation of stress-responsive mtk1/mekk4 mapkkk.
11719	the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-coa and co(2). it contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (e1), lipoamide acyltransferase (e2) and lipoamide dehydrogenase (e3).
11720	
11721	responsible for the synthesis of complex-type n-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
11722	
11723	component of the escrt-iii complex, which is required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs. the mvb pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. the escrt-iii complex is probably involved in the concentration of mvb cargo. required for sorting/trafficking of egf receptor. in case of infection, the hiv-1 virus takes advantage of the escrt-iii complex for budding and exocytic cargos of viral proteins.
11724	may participate in forming intercisternal cross-bridges of the golgi complex.
11725	required for protein transport from the er to the golgi complex.
11726	
11727	component of the inner kinetochore plate. required for normal kinetochore assembly.
11728	angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
11729	
11730	
11731	
11732	
11733	
11734	component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity.
11735	
11736	may be involved in the regulation of gene expression by covalent modification of histone proteins. the long isoform is a corepressor of estrogen receptor (er). the short isoform binds to er and sequesters it in the cytoplasm and enhances non-genomic responses of er.
11737	
11738	
11739	
11740	
11741	
11742	
11743	
11744	
11745	
11746	
11747	
11748	
11749	responsible for the synthesis of complex-type n-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. can produce lactose.
11750	
11751	thiol protease. key protease responsible for the removal of the invariant chain from mhc class ii molecules. the bond- specificity of this proteinase is in part similar to the specificities of cathepsin l and cathepsin n.
11752	bifunctional subunit.
11753	dna-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (ig)/t-cell receptor gene segments. seems to recognize single-stranded dna ends generated by staggered breaks occuring at recombination hot spots.
11754	
11755	integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen c-propeptides, fibronectin and e-cadherin. it recognizes the proline-hydroxylated sequence g-f-p-g-e-r in collagen. it is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
11756	
11757	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
11758	
11759	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
11760	inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the e1 alpha subunit, thus contributing to the regulation of glucose metabolism.
11761	
11762	
11763	
11764	
11765	spermine-binding protein is an androgen regulated ventral prostate glycoprotein that binds various polyamines.
11766	hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. does not have reverse activity.
11767	
11768	gtpase-activating protein (gap) for arf1 and arf5, which also shows strong gtpase activity. isoform 1 participates to the prevention of neuronal apoptosis by enhancing pi3 kinase activity. it aids the coupling of metabotropic glutamate receptor 1 (grm1) to cytoplasmic pi3 kinase by interacting with homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of ngf by activating nuclear pi3 kinase. isoform 2 does not stimulate pi3 kinase but may protect cells from apoptosis by stimulating akt. it also regulates the adapter protein 1 (ap-1)-dependent trafficking of proteins in the endosomal system.
11769	
11770	
11771	receptor for somatostatin with higher affinity for somatostatin-14 than -28. this receptor is coupled via pertussis toxin sensitive g proteins to inhibition of adenylyl cyclase. in addition it stimulates phosphotyrosine phosphatase and na(+)/h(+) exchanger via pertussis toxin insensitive g proteins.
11772	
11773	acts as the target for the cell-cycle arrest and immunosuppressive effects of the fkbp12-rapamycin complex.
11774	
11775	cytokine that binds to tnfrsf13b/taci and to tnfrsf17/bcma. may be implicated in the regulation of tumor cell growth. may be involved in monocyte/macrophage-mediated immunological processes.
11776	
11777	
11778	produces atp from adp in the presence of a proton gradient across the membrane. the alpha chain is a regulatory subunit.
11779	inhibits urokinase-type plasminogen activator. the monocyte derived pai-2 is distinct from the endothelial cell- derived pai-1.
11780	important for bud site selection.
11781	
11782	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
11783	may mediate a process in spermatogenesis or may play a role in sex ratio distortion.
11784	
11785	
11786	
11787	binds to activated cdc42 and rac1 but does not seem to stimulate their gtpase activity. associates with calmodulin.
11788	
11789	
11790	v-snare that mediates vesicle transport pathways through interactions with t-snares on the target membrane. these interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.
11791	
11792	
11793	
11794	
11795	
11796	
11797	
11798	
11799	
11800	
11801	
11802	plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates (by similarity).
11803	binds to all human somatostatin receptor (sstr) subtypes. it also inhibits camp production induced by forskolin through sstrs.
11804	
11805	
11806	transcriptional repressor.
11807	
11808	
11809	
11810	
11811	
11812	
11813	
11814	
11815	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
11816	
11817	
11818	
11819	
11820	
11821	
11822	
11823	
11824	
11825	
11826	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
11827	
11828	
11829	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
11830	binds the sequence 5@#$%&-atcaatcaa-3@#$%&. acts as a transcriptional activator of pf4 in complex with meis1. converted into a potent transcriptional activator by the (1;19) translocation. may have a role in steroidogenesis and, subsequently, sexual development and differentiation.
11831	
11832	
11833	
11834	maintains high levels of reduced glutathione in the cytosol.
11835	
11836	
11837	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
11838	relieves dna strain that arise during duplication of mitochondrial dna.
11839	delays the onset of cell spreading in the early stages of cell adhesion to fibronectin. also involved in calcium- dependent exocytosis from pc12 cells.
11840	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis (by similarity).
11841	possesses intrinsic atp-dependent nucleosome remodelling activity. this activity may be required for transcriptional activation or repression of specific target promoters (by similarity). these may include the serpine1 and hiv-1 promoters and the sv40 enhancer, to which this protein can bind directly.
11842	
11843	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
11844	
11845	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (by similarity).
11846	may be involved in transcriptional regulation.
11847	
11848	
11849	may function in the secretion of milk-fat droplets. may act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (by similarity).
11850	
11851	
11852	blocks the elongation and depolymerization of the actin filaments at the pointed end. the tmod/tm complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (by similarity).
11853	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
11854	
11855	
11856	
11857	in vitro; can phosphorylate exogenous substrates on ser and thr residues. may be involved in the regulation of cellular growth and/or development.
11858	
11859	
11860	
11861	in a snrnp-free form (sf-a) may be involved in coupled pre-mrna splicing and polyadenylation process.
11862	
11863	
11864	
11865	
11866	
11867	
11868	
11869	blocks ras-mediated inhibition of integrin activation and modulates the erk map kinase cascade. inhibits rps6ka3 activities by retaining it in the cytoplasm (by similarity). inhibits both tnfrsf6- and tnfrsf1a-mediated casp8 activity and apoptosis. regulates glucose transport by controlling both the content of slc2a1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of slc2a4 from the cell interior to the surface.
11870	
11871	
11872	
11873	
11874	may function as a phosphatase involved in the regulation of cell growth and differentiation.
11875	may act as a scaffolding protein within caveolar membranes. interacts directly with g-protein alpha subunits and can functionally regulate their activity. may also regulate voltage-gated potassium channels.
11876	
11877	has chemotactic activity for neutrophils. may play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. in vitro, the processed form gro-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
11878	
11879	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling. phosphorylates ctnnb1 on ser-45.
11880	
11881	protein tyrosine phosphatase which stimulates progression from g1 into s phase during mitosis. may play a role in the development and maintenance of differentiating epithelial tissues. enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
11882	
11883	
11884	cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. may play an important role in the development of the nervous system (by similarity).
11885	catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a thr-glu-tyr sequence located in map kinases. activates erk1 and erk2 map kinases.
11886	required for protein transport from the er to the golgi complex.
11887	orphan receptor.
11888	component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. nua4 may also play a direct role in dna repair when directly recruited to sites of dna damage.
11889	
11890	
11891	
11892	may have a role in chylomicrons and vldl secretion and catabolism. required for efficient activation of lipoprotein lipase by apoc-ii; potent activator of lcat. apoa-iv is a major component of hdl and chylomicrons.
11893	cytokine receptor that binds to blc. blr1 exerts possibly a regulatory function in burkitt lymphoma (bl) lymphomagenesis and/or b-cell differentiation. it is a potential candidate for cell-cell interaction, and activation of mature b- lymphocytes in lymphatic tissues.
11894	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters.
11895	
11896	involved in 40s ribosomal subunit biogenesis. it seems to play a role a methylation reaction in pre-rrna processing (by similarity).
11897	required for normal vision and courtship behavior in drosophila.
11898	high-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. may also function as an ecotropic retroviral leukemia receptor.
11899	
11900	
11901	
11902	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
11903	
11904	
11905	
11906	mediates b-cell b-cell interactions. may be involved in the localization of b-cells in lymphoid tissues. binds sialylated glycoproteins; one of which is cd45. preferentially binds to alpha2,6-linked sialic acid. the sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of b-cell antigen receptor signaling. plays a role in positive regulation through interaction with src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their sh2 domains that block signal transduction through dephosphorylation of signaling molecules.
11907	
11908	
11909	
11910	
11911	
11912	
11913	in addition to its role as a glycolytic enzyme, it seems that pgk-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
11914	plays an adhesive role by integrating collagen bundles. it is probably associated with the surface of interstitial collagen fibrils via col1. the col2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large n-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (by similarity).
11915	
11916	
11917	cleaves ubiquitin fusion protein substrates. binds to the herpes virus protein vmw110 which may therefore modulate its substrate specificity or activity to stabilize viral proteins.
11918	
11919	
11920	component of adherens-type cell-cell and cell-matrix junctions. lacks phosphoglucomutase activity.
11921	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes.
11922	
11923	processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. involved in melanosome transport. may also be required for some polarization process involved in dendrite formation.
11924	
11925	
11926	
11927	
11928	
11929	tumor-associated antigen.
11930	promotes the exchange of gdp by gtp. together with leukocyte antigen-related (lar) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.
11931	
11932	
11933	
11934	
11935	
11936	
11937	
11938	
11939	
11940	
11941	
11942	
11943	
11944	
11945	
11946	
11947	
11948	could act as a modulator of transcription.
11949	
11950	may be involved in transcriptional regulation.
11951	
11952	
11953	promotes angiogenesis and the proliferation of endothelial cells. able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
11954	one of the multiple factors required for polyadenylation and 3@#$%&-end cleavage of mammalian pre-mrnas.
11955	
11956	
11957	this is one of the five types (d1 to d5) of receptors for dopamine. the activity of this receptor is mediated by g proteins which inhibit adenylyl cyclase.
11958	tumor-associated antigen.
11959	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
11960	
11961	
11962	
11963	acts as a regulator of traf function by maintaining them in a latent state. overexpression inhibits traf2-mediated nf- kappa-b activation signaled by cd40, tnfr1 and tnfr2. blocks traf2 binding to lmp1 and inhibits lmp1-mediated nf-kappa-b activation.
11964	
11965	
11966	
11967	regulates intracellular concentrations of taurine and glutamate. negatively modulates slc1a1/eaac1 glutamate transport activity by decreasing its affinity for glutamate. may be involved in membrane traffic (by similarity).
11968	
11969	produced by activated monocytes and neutrophils and expressed at sites of inflammation. hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. gro-beta(5-73) shows a highly enhanced hematopoietic activity.
11970	
11971	probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment.
11972	
11973	
11974	
11975	
11976	may be involved in transcriptional regulation.
11977	
11978	
11979	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking among different compartments. modulates vesicle budding and uncoating within the golgi complex. deactivation induces the redistribution of the entire golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. in its gtp-bound form, its triggers the association with coat proteins with the golgi membrane. the hydrolysis of arf1-bound gtp, which is mediated by arfgaps proteins, is required for dissociation of coat proteins from golgi membranes and vesicles.
11980	
11981	
11982	
11983	required for protein transport from the er to the golgi complex.
11984	
11985	binds with high affinity to rna molecules that contain au-rich elements (ares) found within the 3@#$%& untranslated regions of many protooncogenes and cytokine mrnas. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain (by similarity).
11986	transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. retinyl esters are storage forms of vitamin a. lrat plays a critical role in vision. it provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.
11987	functions in nuclear protein import as nuclear transport receptor. serves as receptor for nuclear localization signals (nls) in cargo substrates. is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (npc) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus (by similarity). involved in nuclear import of m9- containing proteins. in vitro, binds directly to the m9 region of the heterogeneous nuclear ribonucleoproteins (hnrnp), a1 and a2 and mediates their nuclear import. appears also to be involved in hnrnp a1/a2 nuclear export. mediates the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones, and srp19.
11988	adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. can bind to fibrinogen, fibronectin, laminin and type v collagen.
11989	
11990	unknown.
11991	
11992	this protein may be a lipid transport protein in schwann cells.
11993	may be involved in meiosis or the maturation of germ cells.
11994	
11995	synthesis and degradation of fructose 2,6-bisphosphate.
11996	
11997	
11998	
11999	
12000	may be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.
12001	
12002	
12003	
12004	prohibitin inhibits dna synthesis. it has a role in regulating proliferation. as yet it is unclear if the protein or the mrna exhibits this effect. may play a role in regulating mitochondrial respiration activity and in aging.
12005	
12006	exhibits outward rectification in a physiological k(+) gradient and mild inward rectification in symmetrical k(+) conditions.
12007	
12008	
12009	irreversible conversion of delta-1-pyrroline-5- carboxylate (p5c), derived either from proline or ornithine, to glutamate. this is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. the preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
12010	activity is required for interleukin 6 (il-6) induced differentiation. may play a role in the growth and differentiation of hematopoietic cells. may be involved in signal transduction in endocardial and arterial endothelial cells.
12011	
12012	
12013	
12014	
12015	not known, associated with cell differentiation.
12016	
12017	
12018	
12019	
12020	
12021	
12022	
12023	
12024	
12025	
12026	
12027	
12028	
12029	
12030	prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
12031	prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
12032	
12033	
12034	
12035	
12036	
12037	
12038	
12039	required for protein transport from the er to the golgi complex.
12040	
12041	
12042	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
12043	
12044	
12045	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
12046	
12047	required for protein transport from the er to the golgi complex.
12048	
12049	putative receptor involved in the development of neural and epithelial tissues.
12050	e3 ubiquitin-protein ligase that accepts ubiquitin from the e2 ubiquitin-conjugating enzyme ube2d1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. it can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
12051	
12052	
12053	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
12054	
12055	
12056	
12057	involved in the release of sentrins (potential).
12058	specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3@#$%&end of 16s rrna in the 30s particle. its inactivation leads to kasugamycin resistance.
12059	specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3@#$%&end of 16s rrna in the 30s particle. its inactivation leads to kasugamycin resistance.
12060	
12061	essential component of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. when overexpressed in cells induces the formation of cytoplasmic annulate lamellae (al) (by similarity).
12062	
12063	
12064	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
12065	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
12066	
12067	
12068	
12069	
12070	
12071	
12072	
12073	
12074	
12075	may function as a transcriptional factor to modulate chondrogenesis in response to the camp pathway.
12076	terminates the action of gaba by its high affinity sodium-dependent reuptake into presynaptic terminals.
12077	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
12078	necessary for spliceosome assembly and for pre-mrna splicing.
12079	
12080	protein transport. probably involved in vesicular traffic (by similarity).
12081	major isoenzyme hydrolyzing the calcium-mobilizing second messenger ins(1,4,5)p3, this is a signal-terminating reaction.
12082	
12083	suppresses the insulin receptor and egfr-transduced mapk signaling pathway, but does not inhibit mapk activation by a constitutively active mutant ras. probably impairs the formation of gtp-ras.
12084	appears to mediate neuronal differentiation.
12085	
12086	
12087	
12088	
12089	required for vesicular transport from the er to the golgi complex. functions as a snare involved in the docking process of er-derived vesicles with the cis-golgi membrane (by similarity).
12090	
12091	carries 11-cis-retinol and 11-cis-retinaldehyde as endogenous ligands and may be a functional component of the visual cycle.
12092	hydrolyzes preferentially nucleoside 5@#$%&-diphosphates, nucleoside 5@#$%&-triphosphates are hydrolyzed only to a minor extent. the order of activity with different substrates is udp >> gdp = cdp = tdp, amp, adp, atp and ump are not substrates. preferred substrates for isoform 2 are ctp, udp, cdp, gtp and gdp, while isoform 1 utilizes utp and ttp.
12093	auxiliary enzyme of beta-oxidation. it participates in the metabolism of unsaturated fatty enoyl-coa esters having double bonds in both even- and odd-numbered positions. catalyzes the nadp-dependent reduction of 2,4-dienoyl-coa to yield trans-3- enoyl-coa.
12094	may serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
12095	
12096	plays a role in cytoplasmic trafficking of rna. binds to the cis-acting response element, a2re.
12097	creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
12098	this antigen is associated with early stages of melanoma tumor progression. may play a role in growth regulation.
12099	may play a role in the er-associated degradation of misfolded glycoproteins.
12100	essential for the control of the cell cycle at the g1/s (start) transition.
12101	
12102	not known.
12103	
12104	probably involved in rna transcription.
12105	
12106	tfiia is a component of the transcription machinery of rna polymerase ii and plays an important role in transcriptional activation. interacts with tbp (the tata-binding protein).
12107	
12108	could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. may contribute to the metastatic phenotype.
12109	may be involved in transcriptional regulation.
12110	
12111	the crk-i and crk-ii forms differ in their biological activities. crk-ii has less transforming activity than crk-i. crk- ii mediates attachment-induced mapk8 activation, membrane ruffling and cell motility in a rac-dependent manner. involved in phagocytosis of apoptotic cells and cell motility via its interaction with dock1 and dock4.
12112	inhibits ipf1/pdx1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (by similarity). in complex with cul3, involved in ubiquitination of both pcgf4 and h2afy.
12113	
12114	
12115	
12116	
12117	
12118	
12119	unknown.
12120	
12121	
12122	
12123	
12124	
12125	
12126	type i collagen is a member of group i collagen (fibrillar forming collagen).
12127	
12128	
12129	
12130	
12131	
12132	
12133	hgf is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. it has no detectable protease activity.
12134	activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (apc/c). during telophase and in the subsequent g1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (d-box) and an additional degradation signal termed the ken box including ase1, cdc20, the b-type cyclins clb2 and clb3, the polo-like kinase cdc5 and hsl1, and recruits them in a c-box-dependent manner to the apc/c for ubiquitination and subsequent proteolysis. required for exit from mitosis, cytokinesis and formation of prereplicative complexes in g1. probably is the target of a bub2-dependent spindle checkpoint pathway.
12135	
12136	
12137	
12138	
12139	
12140	
12141	
12142	has growth-suppressing activity, induces arrest in g1 phase upon controlled expression.
12143	
12144	
12145	
12146	
12147	
12148	
12149	
12150	
12151	
12152	
12153	
12154	
12155	
12156	
12157	may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (by similarity).
12158	
12159	septins are gtpases involved in cytokinesis that assemble into filaments and form a ring at the cleavage site. may act by recruiting myo1 and hof1, a protein involved in septation, to the site of cleavage. septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
12160	
12161	integrin alpha-v/beta-8 is a receptor for fibronectin.
12162	
12163	
12164	
12165	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
12166	may be involved in bmp2-induced transcription (by similarity).
12167	
12168	
12169	factor h functions as a cofactor in the inactivation of c3b by factor i and also increases the rate of dissociation of the c3bbb complex (c3 convertase) and the (c3b)nbb complex (c5 convertase) in the alternative complement pathway.
12170	transport of phosphorylated lysosomal enzymes from the golgi complex and the cell surface to lysosomes. lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low ph mediates the dissociation of the complex. this receptor also binds igf2.
12171	receptor for members of the ephrin-a family. binds to ephrin-a1, -a4 and -a5. binds more poorly to ephrin-a2 and -a3. may play a role in a signal transduction process involved in hindbrain pattern formation.
12172	signal transducer and activator of transcription that mediates signaling by interferons (ifns). following type i ifn (ifn-alpha and ifn-beta) binding to cell surface receptors, jak kinases (tyk2 and jak1) are activated, leading to tyrosine phosphorylation of stat1 and stat2. the phosphorylated stats dimerize, associate with isgf3g/irf-9 to form a complex termed isgf3 transcription factor, that enters the nucleus. isgf3 binds to the ifn stimulated response element (isre) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. in response to type ii ifn (ifn-gamma), stat1 is tyrosine- and serine-phosphorylated. it then forms a homodimer termed ifn-gamma-activated factor (gaf), migrates into the nucleus and binds to the ifn gamma activated sequence (gas) to drive the expression of the target genes, inducing a cellular antiviral state.
12173	
12174	
12175	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. the n-terminus interacts with and regulates xpd whereas an intact c- terminus is required for a successful escape of rnap ii form the promoter.
12176	
12177	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
12178	
12179	
12180	
12181	
12182	
12183	
12184	may serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
12185	
12186	
12187	removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. prefers acyl chain lengths of 14 to 18 carbons.
12188	
12189	may play a role in the regulation of t and b-lymphocyte development and signal transduction.
12190	
12191	
12192	in peripheral tissues, the h1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
12193	
12194	interacts with lrp1/alpha-2-macroglobulin receptor and glycoprotein 330.
12195	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
12196	involved in neutrophil activation. in vitro, ena-78(8- 78) and ena-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.
12197	
12198	
12199	catalyzes the irreversible nadph-dependent deamination of gmp to imp. it functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of g to a nucleotides, and in maintaining the intracellular balance of a and g nucleotides.
12200	
12201	
12202	may be involved in several stages of intracellular trafficking.
12203	
12204	type i collagen is a member of group i collagen (fibrillar forming collagen).
12205	promotes the fragmentation of the mitochondrial network and its perinuclear clustering. can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. also mediates peroxisomal fission.
12206	
12207	
12208	
12209	collagen type iii occurs in most soft connective tissues along with type i collagen.
12210	
12211	mediates homophilic cell-cell adhesion.
12212	apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated fas (cd95) or tnfr-1 receptors. the resulting aggregate called the death-inducing signaling complex (disc) performs caspase-8 proteolytic activation. active caspase-8 initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
12213	nuclease that induces dna fragmentation and chromatin condensation during apoptosis. degrades naked dna and induces apoptotic morphology.
12214	essential for the control of the cell cycle at the g1/s (start) transition.
12215	
12216	hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. may contribute to the native pacemaker currents in heart (if) and in neurons (ih). activated by camp. may mediate responses to sour stimuli.
12217	
12218	
12219	
12220	
12221	binds il13 with a low affinity. together with il4r-alpha can form a functional receptor for il13. also serves as an alternate accessory protein to the common cytokine receptor gamma chain for il4 signaling, but cannot replace the function of gamma c in allowing enhanced il2 binding activity.
12222	orphan receptor.
12223	
12224	may function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. may therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin.
12225	
12226	
12227	unknown.
12228	
12229	
12230	
12231	
12232	
12233	
12234	
12235	
12236	
12237	
12238	
12239	
12240	gtpase-activating protein for rac1 and cdc42. promotes the exchange of rac or cdc42-bound gdp by gtp, thereby activating them. displays serine/threonine kinase activity.
12241	
12242	
12243	
12244	
12245	
12246	
12247	
12248	
12249	
12250	
12251	
12252	
12253	
12254	
12255	
12256	possibly acts as a transcriptional regulatory factor.
12257	involved in several cell fate decisions that require cell-cell interactions. it is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10.
12258	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
12259	nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity (by similarity).
12260	transcription factor which binds specifically to the mef2 element present in the regulatory regions of many muscle- specific genes. activates transcription via this element. may be involved in muscle-specific and/or growth factor-related transcription.
12261	
12262	
12263	binds the ligand binding domain of the thyroid receptor (thrb) in the presence of triiodothyronine and enhances thrb- modulated transcription. golgi auto-antigen; probably involved in maintaining cis-golgi structure.
12264	calcium-regulated non-lysosomal thiol-protease (by similarity).
12265	
12266	
12267	
12268	
12269	muscle contraction.
12270	trap proteins are part of a complex whose function is to bind calcium to the er membrane and thereby regulate the retention of er resident proteins.
12271	
12272	
12273	
12274	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
12275	
12276	
12277	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
12278	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression.
12279	
12280	could regulate beta-glucan synthesis. overexpression provides resistance to hm-1 killer toxin.
12281	
12282	essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. gp30 is a potential ligand for this receptor. not activated by egf, tgf- alpha and amphiregulin.
12283	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
12284	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. this subunit has a chymotrypsin-like activity.
12285	binds to the fc region of immunoglobulins gamma. high affinity receptor.
12286	
12287	
12288	
12289	
12290	extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. it is directly involved in endoplasmic reticulum-associated degradation (erad) and targets misfolded glycoproteins for degradation in an n-glycan-dependent manner. it lacks mannosidase activity.
12291	involved in cell growth regulation. may be involved in the regulation of mitogenic signals and control of cell proliferation. involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (rtk) type, in particular egfr (by similarity).
12292	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
12293	
12294	may be involved in regulating membrane trafficking in the endosomal pathway. overexpression induces endosome aggregation. required to target tom1 to endosomes.
12295	
12296	transports l-glutamate and also l- and d-aspartate. essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. acts as a symport by cotransporting sodium.
12297	
12298	component of the circadian clock or downstream effector of clock function. exhibits a high amplitude circadian rhythm with maximal levels in early evening. in constant darkness or constant light, the amplitude of the rhythm decreases (by similarity).
12299	may be involved in transcriptional regulation.
12300	accessory protein for the calcitonin gene-related peptide (cgrp) receptor. it modulates cgrp responsiveness in a variety of tissues.
12301	
12302	
12303	
12304	
12305	chaperone. isoform 2 may function as an endogenous inhibitory regulator of hsc70 by competing the cochaperones.
12306	probably plays a role in anchoring the complex to other cellular components.
12307	
12308	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
12309	
12310	
12311	part of the snapc complex required for the transcription of both rna polymerase ii and iii small-nuclear rna genes. binds to the proximal sequence element (pse), a non-tata-box basal promoter element common to these 2 types of genes. recruits tbp and brf2 to the u6 snrna tata box.
12312	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes.
12313	component of the cleavage factor im (cfim) complex that plays a key role in pre-mrna 3@#$%& processing. involved in association with cpsf6 in pre-mrna 3@#$%&-end poly(a) site cleavage and poly(a) addition. nudt21/cpsf5 binds to cleavage and polyadenylation rna substrates.
12314	type i collagen is a member of group i collagen (fibrillar forming collagen).
12315	
12316	
12317	
12318	
12319	3-phosphorylates the cellular phosphoinositide ptdins- 4,5-biphosphate (ptdins(4,5)p2) to produce ptdins-3, 4,5- triiphosphate (ptdins(3,4,5)p3). links g-protein coupled receptor activation to the secondary messenger ptdins(3,4,5)p3 production.
12320	receptor on natural killer (nk) cells for hla-c alleles. does not inhibit the activity of nk cells.
12321	this is the smallest of the 5 chains of the enzymatic component (coupling factor cf(1)) of the mitochondrial atpase complex (by similarity).
12322	binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. may mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
12323	necessary for the synthesis of n-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in gpi-anchor biosynthesis.
12324	
12325	
12326	
12327	involved in several cell fate decisions that require cell-cell interactions. it is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10.
12328	
12329	
12330	
12331	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
12332	
12333	
12334	may have a role in promoting cell migration (motogen).
12335	receptor for all-trans- and 11-cis-retinal. binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.
12336	probable transcription regulator.
12337	
12338	
12339	
12340	
12341	
12342	
12343	
12344	
12345	
12346	
12347	
12348	acts as a regulatory subunit of the 26 proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
12349	thought to form a receptor-activated non-selective calcium permeant cation channel. probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or g-protein coupled receptors. seems to be also activated by intracellular calcium store depletion.
12350	
12351	
12352	
12353	
12354	
12355	
12356	
12357	
12358	
12359	may play a role in the initial growth and guidance of axons. may be involved in cell adhesion.
12360	
12361	
12362	
12363	
12364	
12365	
12366	
12367	
12368	
12369	probably involved in connections of major cytoskeletal structures to the plasma membrane.
12370	probable transcriptional activator.
12371	
12372	muscle contraction.
12373	
12374	
12375	
12376	
12377	
12378	
12379	in vitro; can phosphorylate exogenous substrates on ser and thr residues. may be involved in the regulation of cellular growth and/or development.
12380	circadian regulator that may act as a transcription factor. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition. the expression rhythms appear to originate from retina (by similarity).
12381	
12382	
12383	
12384	
12385	type xii collagen interacts with type i collagen- containing fibrils, the col1 domain could be associated with the surface of the fibrils, and the col2 and nc3 domains may be localized in the perifibrillar matrix (by similarity).
12386	involved in cytokinesis (potential).
12387	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
12388	ucp are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. as a result, energy is dissipated in the form of heat. may play a role in the modulation of tissue respiratory control. participates in thermogenesis and energy balance.
12389	mediates the na(+)-independent transport of organic anions such as sulfobromophthalein (bsp) and conjugated (taurocholate) and unconjugated (cholate) bile acids (by similarity).
12390	
12391	phosphorylates on ser and thr residues the goodpasture autoantigen (in vitro). isoform 2 seems to be less active.
12392	
12393	
12394	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
12395	induces a hyperpolarization-activated chloride current when expressed in xenopus oocytes. may be a modulator capable of activating endogenous oocyte channels.
12396	
12397	catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. has little activity towards prostaglandins a1 and e1.
12398	
12399	
12400	acts at e2f-responsive promoters to integrate signals provided by phd- and/or bromodomain-containing transcription factors (by similarity).
12401	
12402	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
12403	plays an important role in fat metabolism. it preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
12404	inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (by similarity).
12405	
12406	potentiates but cannot initiate fas-induced apoptosis.
12407	
12408	inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. may mediate the inhibitory effect of rac1 on endocytosis.
12409	
12410	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
12411	granzyme b inhibitor.
12412	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
12413	specifically hydroxylates an asp or asn residue in certain epidermal growth factor-like (egf) domains of a number of proteins.
12414	
12415	
12416	potential tumor suppressor. acts as a kras-specific effector protein. may promote apoptosis and cell cycle arrest.
12417	
12418	
12419	
12420	
12421	plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. inhibits membrane fusion between transport vesicles and the plasma membrane. may modulate the assembly of trans-snare complexes between transport vesicles and the plasma membrane. inhibits translocation of glut4 from intracellular vesicles to the plasma membrane. competes with stxbp1 for stx1 binding (by similarity).
12422	
12423	
12424	
12425	
12426	
12427	
12428	dual specificity kinase. is activated by cytokines and environmental stress in vivo. catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the map kinase p38.
12429	
12430	
12431	
12432	
12433	
12434	
12435	
12436	cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. converts leukotriene c4 (ltc4) to leukotriene d4 (ltd4).
12437	
12438	may play a role in meiosis as well as in neuron differentiation and/or function (by similarity).
12439	
12440	
12441	
12442	
12443	plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine.
12444	
12445	
12446	
12447	
12448	
12449	
12450	
12451	
12452	
12453	
12454	involved in the presentation of foreign antigens to the immune system.
12455	
12456	
12457	
12458	
12459	
12460	
12461	
12462	
12463	
12464	may have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor.
12465	immediate-early protein likely to play a role in cell growth regulation (by similarity).
12466	
12467	
12468	
12469	
12470	
12471	may play a key role in signal transduction and growth control.
12472	
12473	
12474	plays a role in the formation of clathrin-coated invaginations and endocytosis.
12475	
12476	
12477	may have an e3 ubiquitin ligase activity. may play a significant role in mediating the biological activity of the hiv-1 tat protein in vivo. binds specifically to the activation domain of hiv-1 tat and can also interact with the hiv-2 and eiav tat proteins in vivo.
12478	
12479	
12480	
12481	
12482	
12483	
12484	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
12485	
12486	mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient. it is a tetrodotoxin-sensitive na(+) channel isoform. plays a role in pain mechanisms, especially in the development of inflammatory pain (by similarity).
12487	possible involvement in extravasation of leukocytes.
12488	
12489	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
12490	
12491	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. displays high levels of activity on medium- and long chain acyl coas.
12492	
12493	may be involved in transcriptional regulation.
12494	putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. preferentially binds to alpha2,6-linked sialic acid. the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. in the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their sh2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. induces apoptosis in acute myeloid leukemia (in vitro).
12495	
12496	
12497	
12498	
12499	receptor for prostaglandin f2-alpha (pgf2-alpha). the activity of this receptor is mediated by g proteins which activate a phosphatidylinositol-calcium second messenger system. initiates luteolysis in the corpus luteum (by similarity).
12500	
12501	
12502	
12503	involved in muscle differentiation (myogenic factor). induces fibroblasts to differentiate into myoblasts. activates muscle-specific promoters. interacts with and is inhibited by the twist protein. this interaction probably involves the basic domains of both proteins (by similarity).
12504	
12505	probably important in the developing nervous system.
12506	
12507	
12508	
12509	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex.
12510	chemotactic for monocytes and t-lymphocytes. binds to cxcr3.
12511	may be involved in several stages of intracellular trafficking (by similarity).
12512	
12513	regulates intra- and extracellular levels of inorganic pyrophosphate (ppi), probably functioning as ppi transporter.
12514	
12515	
12516	
12517	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
12518	acts as an a-kinase anchoring protein by binding to the type ii regulatory subunit of protein kinase a and anchoring it to the mitochondrion. also involved in synchronization of mitochondrial fission.
12519	fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
12520	essential component of the scf (skp1-cul1-f-box protein) e3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. in the scf complex, serves as a rigid scaffold that organizes the skp1-f-box protein and rbx1 subunits. may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
12521	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
12522	
12523	
12524	
12525	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
12526	
12527	
12528	exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities.
12529	
12530	amp deaminase plays a critical role in energy metabolism.
12531	the insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.
12532	
12533	
12534	may be involved in modulating chromatin formation and contribute to regulation of cell proliferation.
12535	
12536	presents carbohydrate ligands to selectins. also implicated in tumor cell metastasis.
12537	
12538	angiogenesis inhibitor. inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. this inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. acts in an autocrine manner.
12539	serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors creb (camp response element-binding protein) and atf1 (activating transcription factor-1). essential role in the control of rela transcriptional activity in response to tnf. directly represses transcription via phosphorylation of ser-1 of histone h2a. mediates the mitogen- and stress-induced phosphorylation of histone h3 and high mobility group protein 14 (hmg-14).
12540	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
12541	
12542	
12543	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
12544	
12545	
12546	promotes cell adhesion (by similarity).
12547	
12548	
12549	catalyzes the transfer of ptdins and phosphatidylcholine between membranes.
12550	
12551	
12552	
12553	required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors. may bind a rab gtpase such as vps21.
12554	
12555	seems to be a intermediate filament associated protein that links endocytic vesicles to microtubules.
12556	
12557	
12558	
12559	
12560	
12561	
12562	a spliceosome-associated protein; may play a role in cross-intron bridging of u1 and u2 snrnps in the mammalian a complex.
12563	
12564	involved in calcium binding and microtubule stabilization.
12565	
12566	
12567	
12568	
12569	
12570	
12571	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
12572	
12573	
12574	
12575	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
12576	
12577	
12578	
12579	
12580	
12581	
12582	
12583	
12584	
12585	
12586	
12587	
12588	
12589	
12590	
12591	
12592	
12593	
12594	this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of sodium and potassium ions across the plasma membrane. this action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
12595	not yet known, orphan transporter.
12596	
12597	
12598	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules.
12599	
12600	
12601	
12602	essential for the development of polarized epithelia and for cell polarity associated with asymmetric cell division of neuroblasts during development. isoform p78 has an essential role in control of cell proliferation and differentiation during development and could act as tumor suppressor. isoform p217 has an accessory function in this respect.
12603	
12604	
12605	
12606	
12607	
12608	
12609	tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. phosphorylates stat6, irs1, irs2 and pi3k.
12610	type iv collagen is the major structural component of glomerular basement membranes (gbm), forming a @#$%&chicken-wire@#$%& meshwork together with laminins, proteoglycans and entactin/nidogen.
12611	
12612	
12613	
12614	extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. regulates microtubule function in neurons and neuronal migration. affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. enzymatic activity is important for the modulation of cell adhesion. binding to the extracellular domains of lipoprotein receptors vldlr and apoer2 induces tyrosine phosphorylation of dab1 and modulation of tau phosphorylation (by similarity).
12615	
12616	plays a role in the toxic effects of organotins.
12617	
12618	saposin d is a specific sphingomyelin phosphodiesterase activator (ec 3.1.4.12).
12619	
12620	
12621	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (by similarity). probably encodes a dihydropyridine-insensitive current. vital for survival to adulthood.
12622	
12623	transports nucleotide sugars from the cytosol into golgi vesicles where glycosyltransferases function.
12624	
12625	e3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. regulates apoptosis by catalyzing the polyubiquitination and degradation of mcl1. also ubiquitinates the p53 tumor suppressor and core histones including h1, h2a, h2b, h3 and h4. binds to an upstream initiator-like sequence in the preprodynorphin gene.
12626	
12627	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
12628	f-actin capping proteins bind in a ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
12629	required for normal golgi morphology and function.
12630	the association of the dr1/drap1 heterodimer with tbp results in a functional repression of both activated and basal transcription of class ii genes. this interaction precludes the formation of a transcription-competent complex by inhibiting the association of tfiia and/or tfiib with tbp. can bind to dna on its own.
12631	
12632	
12633	gfap, a class-iii intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
12634	
12635	
12636	involved in the presentation of foreign antigens to the immune system.
12637	
12638	
12639	
12640	
12641	
12642	works in concert with the 5alpha/5beta-steroid reductases to convert steroid hormones into the 3alpha/5alpha and 3alpha/5beta-tetrahydrosteroids. catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5alpha-dht) to 5-alpha-androstane-3alpha,17beta-diol (3-alpha-diol).
12643	collagen type iv is specific for basement membranes. vital for embryonic development.
12644	involved in microtubule organization by the microtubule organizing center, the spindle pole body (spb). probably part of the microtubule attachment site at the spb.
12645	ubiquitin-like modifier protein which binds to a number of as yet unidentified target proteins.
12646	
12647	
12648	
12649	induces cardiac myocyte hypertrophy in vitro. binds to and activates the ilst/gp130 receptor.
12650	may be required for cell division and may have a role during g1 or s phase.
12651	involved in the targeting and/or fusion of transport vesicles to their target membrane.
12652	may play a role in antiviral host defense. protects against infection by a neurovirulent strain of sindbis virus. may play a role in autophagy.
12653	component of the smcc mediator complex, a complex that can either repress or activate transcription. mediator complexes are essential for basal and regulated expression of nearly all rna polymerase ii-dependent genes. they may act as a bridge, conveying regulatory information from enhancers and other control elements to the promoter. the smcc mediator complex can also act independently of the rna polymerase ii ctd.
12654	
12655	
12656	activates the jnk pathway. plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. phosphorylates and inactivates the protein phosphatase ssh1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. decreased cofilin activity may lead to stabilization of actin filaments.
12657	may play a role in the regulation of ionic transport. binds calcium.
12658	binds to cytidine clusters in double-stranded dna.
12659	the gamma-ctf peptides as well as the caspase-cleaved peptides, including c31, are potent enhancers of neuronal apoptosis.
12660	
12661	
12662	
12663	factor viii, along with calcium and phospholipid, acts as a cofactor for factor ixa when it converts factor x to the activated form, factor xa.
12664	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
12665	
12666	has an effect on position-effect variegation.
12667	
12668	
12669	
12670	
12671	
12672	
12673	
12674	
12675	band 3 is the major integral glycoprotein of the erythrocyte membrane. band 3 has two functional domains. its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin.
12676	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&. activates transcription of pf4 in complex with meis1.
12677	
12678	
12679	
12680	
12681	transcription factor which binds specifically to the mef2 element present in the regulatory regions of many muscle- specific genes. activates transcription via this element. may be involved in muscle-specific and/or growth factor-related transcription.
12682	
12683	
12684	
12685	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. combines rna-binding and ppiase activities (by similarity).
12686	
12687	
12688	
12689	
12690	
12691	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling. phosphorylates ctnnb1 on ser-45.
12692	mediates the voltage-dependent potassium ion permeability of excitable membranes. channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
12693	catalyzes the adenylation by atp of the carboxyl- terminal glycine of this.
12694	eliminates the production of nonsense-containing rnas (by similarity).
12695	3@#$%&-to-5@#$%& exoribonuclease specific for small oligoribonucleotides. active on small (primarily </=5 nucleotides in length) single-stranded rna and dna oligomers. may have a role for cellular nucleotide recycling.
12696	hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
12697	
12698	
12699	
12700	calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. it may act in assisting protein assembly and/or in the retention within the er of unassembled protein subunits. it seems to play a major role in the quality control apparatus of the er by the retention of incorrectly folded proteins.
12701	may be associated with the transformation of neuroendocrine cells.
12702	
12703	
12704	
12705	
12706	component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity.
12707	
12708	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
12709	may be involved in transcriptional regulation.
12710	bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. catalyzes the formation of 3- ketoacyl-coa intermediates from both straight-chain and 2-methyl- branched-chain fatty acids (by similarity).
12711	
12712	
12713	
12714	
12715	
12716	transcription activator that binds dna cooperatively with dp proteins through the e2 recognition site, 5@#$%&-tttc[cg]cgc- 3@#$%& found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the drtf1/e2f complex functions in the control of cell-cycle progression from g1 to s phase. e2f-4 binds with high affinity to p107 and p130. in some instances, can also bind rb protein.
12717	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling.
12718	integrin alpha-v/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von willebrand factor. integrin alpha-iib/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. integrins alpha-iib/beta-3 and alpha-v/beta-3 recognize the sequence r-g-d in a wide array of ligands. integrin alpha-iib/beta-3 recognizes the sequence h-h-l-g-g-g-a-k-q-a-g-d-v in fibrinogen gamma chain. following activation integrin alpha- iib/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. this step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
12719	may be involved in several stages of intracellular trafficking (by similarity).
12720	required for synthesis of pyridoxal-5-phosphate from vitamin b6.
12721	
12722	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. displays glutathione peroxidase activity with cumene hydroperoxide.
12723	ubiquitin-like protein which binds to a wide range of target proteins. does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. plays a role in a number of cellular processes such as nuclear transport, dna replication and repair, mitosis and signal transduction. involved in targeting rangap1 to the nuclear pore complex protein ranbp2.
12724	
12725	may play a role in cell-cell recognition and signaling.
12726	protein kinase that is involved in mitotic regulation. may have a role at the g2-m transition. may also play a role in meiosis. isoform 1 but not isoform 2 appears to play a role in centrosome splitting. isoform 1 phosphorylates and activates nek11 in g1/s-arrested cells. isoform 2, which is not present in the nucleolus, does not.
12727	
12728	
12729	acts as a transcriptional regulator of pax6. acts as a transcriptional activator of pf4 in complex with pbx1 or pbx2. required for hematopoiesis, megakaryocyte lineage development and vascular patterning. may function as a cofactor for hoxa7 and hoxa9 in the induction of myeloid leukemias.
12730	calcium/calmodulin-dependent enzyme responsible for smooth muscle contraction via phosphorylation of a specific serine in the n-terminus of myosin light chains (mlc), an event that facilitates myosin interaction with actin filaments. central determinant in the development of vascular permeability and tissue edema formation. in the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. critical participant in signaling sequences that result in fibroblast apoptosis.
12731	
12732	
12733	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. binds poly(rg).
12734	
12735	general coactivator that functions cooperatively with tafs and mediates functional interactions between upstream activators and the general transcriptional machinery. binds single-stranded dna.
12736	
12737	involved in peroxisome biosynthesis and integrity. assembles membrane vesicles before the matrix proteins are translocated. as a docking factor for pex19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
12738	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
12739	
12740	
12741	involved in high-affinity copper uptake.
12742	may participate in diverse steps of neurogenesis. binds calcium.
12743	
12744	ensures, in conjunction with srp, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.
12745	upstream regulator of interferon-induced serine/threonine protein kinase r (pkr). may block the pkr- inhibitory function of p58ipk, resulting in restoration of kinase activity and suppression of cell growth.
12746	
12747	may be involved in fusion of er-derived transport vesicles with the golgi complex.
12748	the s.cerevisiae ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-amp.
12749	
12750	
12751	
12752	inhibits activated protein c as well as plasminogen activators.
12753	
12754	
12755	acetyltransferase enzyme. acetylates histones, giving a specific tag for transcriptional activation. also acetylates non- histone proteins, like ncoa3 coactivator. mediates camp-gene regulation by binding specifically to phosphorylated creb protein. cbp, as coactivator, augments the activity of phosphorylated creb to activate transcription of camp-responsive genes.
12756	
12757	
12758	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
12759	
12760	involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. may be involved in the release of components of the bilayered coat from the endosomal membrane. the association with escrt-iii complex mediates the atp- dependent disassembly of the escrt-iii complex. in case of infection, the hiv-1 virus takes advantage of it for budding and exocytic cargos of viral proteins.
12761	
12762	
12763	
12764	
12765	
12766	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
12767	this protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate (by similarity).
12768	
12769	
12770	
12771	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
12772	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
12773	
12774	
12775	
12776	tumor-associated antigen.
12777	
12778	
12779	
12780	
12781	
12782	
12783	
12784	
12785	probable e3 ubiquitin ligase protein, which mediates ubiquitination and subsequent proteasomal degradation of target proteins. may function as a facilitator or regulator of transcriptional activation by myc. may have a role during synaptogenesis.
12786	
12787	
12788	
12789	
12790	
12791	
12792	
12793	
12794	
12795	
12796	
12797	
12798	
12799	required for protein transport from the er to the golgi complex.
12800	
12801	
12802	
12803	
12804	
12805	
12806	
12807	
12808	ligand for cd2. might facilitate interaction between activated lymphocytes. probably involved in regulating t-cell activation.
12809	
12810	
12811	
12812	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
12813	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
12814	
12815	this is a receptor for retinoic acid. this metabolite has profound effects on vertebrate development. retinoic acid is a morphogen and is a powerful teratogen. this receptor controls cell function by directly regulating gene expression.
12816	involved in transcription.
12817	
12818	collagen type iii occurs in most soft connective tissues along with type i collagen.
12819	
12820	
12821	functions as a sorting receptor in the golgi compartment and as a clearance receptor on the cell surface. required for protein transport from the golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (m6pr). also required for protein transport from the golgi apparatus to the endosomes. promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of bdnf (probdnf) and ngfb (prongfb). also acts as a receptor for neurotensin. may promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular lpl. probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter slc2a4/glut4 (glut4 storage vesicles, or gsvs). these vesicles provide a stable pool of slc2a4 and confer increased responsiveness to insulin. may also mediate transport from the endoplasmic reticulum to the golgi.
12822	
12823	component of pa700, an atp-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20s proteasome) of the 26s complex. specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone t3-independent manner) and with retinoid x receptor (rxr). could be e3 ubiquitin- protein ligase which accepts ubiquitin from an e2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
12824	signal-transducing molecule. may have a common pathway with il6st. the soluble form inhibits the biological activity of lif by blocking its binding to receptors on target cells.
12825	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
12826	
12827	
12828	
12829	plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. could be an adhesion molecule active in neural crest cells during embryonic development. acts as surface receptor that triggers tyrosine phosphorylation of fyn and ptk2, and a transient increase in the intracellular calcium concentration.
12830	
12831	
12832	possesses a trypsin-like cleavage specificity (by similarity).
12833	
12834	
12835	
12836	
12837	necessary for efficient rna polymerase ii transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by s-ii allows the resumption of elongation from the new 3@#$%&terminus.
12838	
12839	
12840	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. socs5 is involved in regulating t-helper cell differentiation by inhibition of the il4 signaling pathway which promotes differentiation into the th2 phenotype. can also partially inhibit il6 and lif signaling (by similarity).
12841	component of the nuclear body, also known as nuclear domain 10, pml oncogenic domain, and kr body. may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.
12842	promotes the exchange of gdp by gtp (by similarity).
12843	does not act as an allosteric activator of the cholera toxin catalytic subunit. component of a regulated secretory pathway involved in ca(2+)-dependent release of acetylcholine.
12844	
12845	
12846	
12847	
12848	
12849	
12850	
12851	type i collagen is a member of group i collagen (fibrillar forming collagen).
12852	
12853	implicated as a tumor suppressor. may have a function in vesicular transport. interaction between hamartin and tuberin may facilitate vesicular docking.
12854	
12855	
12856	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
12857	
12858	non-specific receptor for endothelin 1, 2, and 3. mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system.
12859	
12860	
12861	binds calmodulin in a calcium dependent manner. may function as scaffolding or signaling protein.
12862	
12863	
12864	
12865	catalyzes the conversion of gamma-aminobutyrate and l- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. can also convert delta-aminovalerate and beta-alanine.
12866	
12867	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
12868	
12869	
12870	
12871	
12872	not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
12873	
12874	
12875	
12876	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
12877	
12878	
12879	
12880	collagen vi acts as a cell-binding protein.
12881	
12882	
12883	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
12884	
12885	
12886	
12887	
12888	
12889	
12890	
12891	
12892	
12893	
12894	
12895	
12896	
12897	
12898	
12899	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
12900	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
12901	
12902	
12903	
12904	
12905	
12906	
12907	
12908	binds to g-rich structures in 28s rrna and in mrnas. plays a regulatory role in the translation apparatus; inhibits cell-free translation of mrnas.
12909	important modulator in the hla class ii restricted antigen presentation pathway by interaction with the hla-dm molecule.
12910	
12911	
12912	
12913	
12914	
12915	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
12916	
12917	may be involved in transcriptional regulation.
12918	
12919	required for meiotic chromosome synapsis and cell cycle progression. may act as a molecular zipper to bring homologous chromosomes in close apposition. zip1 may encode the transverse filaments of the synaptonemal complex.
12920	
12921	
12922	
12923	required for assembly and activity of the vacuolar atpase. potential role in differential targeting and regulation of the enzyme for a specific organelle (by similarity).
12924	may be involved in n-glycosylation through its association with n-oligosaccharyl transferase.
12925	
12926	
12927	fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, dna, and actin. fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. interaction with tnr mediates inhibition of cell adhesion and neurite outgrowth (by similarity).
12928	
12929	
12930	probably involved in nervous system development and function.
12931	
12932	
12933	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
12934	
12935	
12936	
12937	major acute phase reactant. apolipoprotein of the hdl complex.
12938	dorsalizing factor. key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing tgf-beta family bone morphogenetic proteins (bmps) and sequestering them in latent complexes (by similarity).
12939	
12940	
12941	converts specific uridines to psi in a number of trna substrates. acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing trna. involved in regulation of nuclear receptor activity possibly through pseudouridylation of sra1 rna (by similarity).
12942	sodium-independent, high-affinity transport of large neutral amino acids. involved in cellular amino acid uptake.
12943	
12944	
12945	
12946	
12947	
12948	
12949	
12950	catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in rab proteins with an -xxcc, -xcxc and -ccxx c-terminal, such as rab1a, rab3a and rab5a respectively.
12951	lysophoshatidylglycerol (lpg) specific acyltransferase that recognizes various acyl-coas and lpgs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-coas and oleoyl-coa as acyl donors. prefers oleoyl-lpg over palmitoyl-lpg as an acyl receptor and oleoyl-coa over lauroyl-coa as an acyl donor.
12952	involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. mediates its effects by interactions with a number of other regulators of apoptosis. isoform 1 inhibits apoptosis while isoform 2 promotes it.
12953	involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. mediates its effects by interactions with a number of other regulators of apoptosis. isoform 1 inhibits apoptosis while isoform 2 promotes it.
12954	
12955	
12956	calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction.
12957	type i collagen is a member of group i collagen (fibrillar forming collagen).
12958	may play a role in the control of gene expression.
12959	
12960	receptor for oxytocin. the activity of this receptor is mediated by g proteins which activate a phosphatidylinositol- calcium second messenger system.
12961	
12962	may facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery.
12963	interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite dna, called the cenp-b box. may organize arrays of centromere satellite dna into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (by similarity).
12964	
12965	may function in the secretion of milk-fat droplets. may act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (by similarity).
12966	
12967	acts as a positive regulator of apoptosis.
12968	
12969	involved in the splicing process and participates in early heat shock-induced splicing arrest. due to their great structural variations the different isoforms may possess different functions in the splicing reaction.
12970	may play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage.
12971	
12972	does not act as an allosteric activator of the cholera toxin catalytic subunit (by similarity).
12973	
12974	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling (by similarity).
12975	atp-dependent rna helicase (potential).
12976	
12977	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
12978	
12979	
12980	probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. can be blocked by extracellular barium and cesium.
12981	may function as a transcription factor. seems to repress transcription.
12982	may function in the process of apoptosis.
12983	may antagonize nodal signaling and subsequent organization of axial structures during mesodermal patterning (by similarity).
12984	this protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.
12985	
12986	
12987	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
12988	transcriptional activator that binds to dna sequences containing the consensus 5@#$%&-wgga-3@#$%&. transactivates promoters of the hematopoietic growth factor genes csf2, il3, il8, and of the bovine lysozyme gene. acts synergistically with runx1 to transactivate the il3 promoter. also transactivates the prf1 promoter in natural killer (nk) cells. plays a role in the development and function of nk and nk t-cells and in innate immunity.
12989	
12990	high affinity receptor for activated thrombin coupled to g proteins that stimulate phosphoinositide hydrolysis.
12991	
12992	
12993	protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation.
12994	
12995	
12996	transcription factor that binds preferentially to a variant of the octamer motif (5@#$%&-atgataat-3@#$%&) (by similarity).
12997	
12998	probable serine hydrolase. may be related to cell muscle hypertrophy.
12999	
13000	
13001	
13002	
13003	
13004	required for the accumulation of coenzyme a in the mitochondrial matrix.
13005	
13006	
13007	
13008	
13009	
13010	
13011	
13012	
13013	hgf is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. it has no detectable protease activity.
13014	
13015	
13016	
13017	
13018	
13019	
13020	
13021	
13022	
13023	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
13024	
13025	cbf binds to the core site, 5@#$%&-pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, lck, il-3 and gm-csf promoters. the alpha subunit binds dna and appears to have a role in the development of normal hematopoiesis. isoform aml-1l interferes with the transactivation activity of runx1. acts synergistically with elf4 to transactivate the il-3 promoter and with elf2 to transactivate the mouse blk promoter. inhibits myst4- dependent transcriptional activation.
13026	
13027	
13028	
13029	responsible for the deiodination of t4 (3,5,3@#$%&,5@#$%&- tetraiodothyronine) into t3 (3,5,3@#$%&-triiodothyronine). essential for providing the brain with appropriate levels of t3 during the critical period of development.
13030	
13031	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
13032	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
13033	
13034	aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
13035	
13036	
13037	
13038	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
13039	
13040	
13041	
13042	may be involved in transcriptional regulation.
13043	
13044	
13045	
13046	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
13047	
13048	
13049	
13050	
13051	
13052	seems to act as a transcriptional repressor.
13053	dorsalizing factor. key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing tgf-beta family bone morphogenetic proteins (bmps) and sequestering them in latent complexes (by similarity).
13054	
13055	may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.
13056	
13057	may contribute to sister chromatid cohesion (by similarity).
13058	general activator of rna polymerase which utilizes different tfiiib complexes at structurally distinct promoters. the isoform 1 is involved in the transcription of trna, adenovirus va1, 7sl and 5s rna. isoform 2 is required for transcription of the u6 promoter.
13059	integrin alpha-x/beta-2 is a receptor for fibrinogen. it recognizes the sequence g-p-r in fibrinogen. it mediates cell-cell interaction during inflammatory responses. it is especially important in monocyte adhesion and chemotaxis.
13060	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
13061	the activated kinase acts on a variety of targets (by similarity).
13062	
13063	
13064	may eliminate potentially toxic dinucleoside polyphosphates during sporulation. most active against diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p6-hexaphosphate (ap6a). can also hydrolyze diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p5-pentaphosphate (ap5a), adenosine 5@#$%&-pentaphosphate, and adenosine 5@#$%&-tetraphosphate are also substrates, but not diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p4-tetraphosphate (ap4a) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. also cleaves a beta-phosphate from the diphosphate groups in pp-insp5 (diphosphoinositol pentakisphosphate) and [pp]2-insp4 (bisdiphosphoinositol tetrakisphosphate).
13065	
13066	
13067	creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
13068	in vitro; can phosphorylate histones h3 and h2b on ser and thr residues. may be involved in the regulation of cellular growth and/or development.
13069	
13070	guanine-nucleotide-releasing protein that acts on members of the sce4/ypt1/rab subfamily. stimulates gdp release from both ypt1 and rab3a, but is less active on these proteins than on the sec4 protein. might play a general role in vesicular transport.
13071	
13072	
13073	single stranded dna-dependent atp-dependent helicase. has a role in chromosome translocation. the dna helicase ii complex binds preferentially to fork-like ends of double-stranded dna in a cell cycle-dependent manner. it works in the 3@#$%&-5@#$%& direction. binding to dna may be mediated by p70. involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination. the ku p70/p86 dimer acts as regulatory subunit of the dna-dependent protein kinase complex dna-pk by increasing the affinity of the catalytic subunit prkdc to dna by 100-fold. the ku p70/p86 dimer is probably involved in stabilizing broken dna ends and bringing them together. the assembly of the dna-pk complex to dna ends is required for the nhej ligation step. in association with narg1, the ku p70/p86 dimer binds to the osteocalcin promoter and activates osteocalcin expression.
13074	
13075	
13076	
13077	acts as a transcriptional repressor. may play a role in limb-pattern formation. acts in cranofacial development and specifically in odontogenesis.
13078	endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. cleaves heparan sulfate proteoglycans (hspgs) into heparan sulfate side chains and core proteoglycans. also implicated in the extravasation of leukocytes and tumor cell lines. due to its contribution to metastasis and angiogenesis, it is considered to be a potential target for anti- cancer therapies.
13079	supplies the nucleotide substrate for thymidylate synthetase.
13080	
13081	
13082	
13083	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. the n-terminus interacts with and regulates xpd whereas an intact c- terminus is required for a successful escape of rnap ii form the promoter.
13084	may function in the secretion of milk-fat droplets. may act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (by similarity).
13085	srf is a transcription factor that binds to the serum response element (sre), a short sequence of dyad symmetry located 300 bp to the 5@#$%& of the site of transcription initiation of some genes (such as fos).
13086	prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
13087	not known; potential regulator of cellular growth.
13088	
13089	
13090	
13091	
13092	promote mitochondrial fission (by similarity).
13093	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
13094	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
13095	thought to be required for maintaining cell proliferation.
13096	
13097	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
13098	probable serine protease.
13099	this protein mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
13100	seems to be required for the activation of 5-lo (5- lipoxygenase). flap could play an essential role in the transfer of arachidonic acid to 5-lo. flap binds to mk-886, a compound that blocks the biosynthesis of leukotrienes.
13101	binds to heparin. induces cell attachment and spreading and plays a role in cell adhesion.
13102	
13103	binds to disheveled (dvl) and rho, and mediates wnt- induced dvl-rho complex formation. may play a role as a scaffolding protein to recruit rho-gdp and rho-gef, thereby, enhancing rho-gtp formation.
13104	may play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. may modulate sc6a1/gat1-mediated gaba uptake by stabilizing the transporter. required for localization of vil2 to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (by similarity).
13105	seems to act exclusively upon threonine residues (by similarity).
13106	
13107	
13108	
13109	
13110	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
13111	
13112	could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. pro-apoptotic protein that functions intracellularly upstream of jnk activation and cytochrome c release.
13113	
13114	
13115	component of the asymmetric unit membrane (aum); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. may play an important role in aum-cytoskeleton interaction in terminally differentiated urothelial cells. it also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (by similarity).
13116	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
13117	could be a global transcriptional regulator. modifies gene expression by affecting chromatin. may be involved in brain development and facial morphogenesis.
13118	
13119	
13120	essential component of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. when overexpressed in cells induces the formation of cytoplasmic annulate lamellae (al) (by similarity).
13121	orphan receptor.
13122	
13123	
13124	
13125	
13126	recognizes and binds the 7-methylguanosine-containing mrna cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mrnas secondary structures.
13127	
13128	
13129	recognizes the ribosomal rna gene promoter and activates transcription mediated by rna polymerase i through cooperative interactions with the species-specific factor sl1. it binds specifically to the upstream control element.
13130	
13131	
13132	
13133	
13134	
13135	
13136	
13137	
13138	potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.
13139	
13140	
13141	
13142	
13143	
13144	
13145	
13146	
13147	
13148	
13149	
13150	signaling adapter that couples activated growth factor receptors to signaling pathway. isoform p46shc and isoform p52shc, once phosphorylated, couple activated receptor tyrosine kinases to ras via the recruitment of the grb2/sos complex and are implicated in the cytoplasmic propagation of mitogenic signals. isoform p46shc and isoform p52shc may thus function as initiators of the ras signaling cascade in various nonneuronal systems. isoform p66shc does not mediate ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. isoform p66shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. the expression of isoform p66shc has been correlated with life span (by similarity).
13151	
13152	
13153	
13154	3beta-hsd is a bifunctional enzyme, that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. the 3beta-hsd enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
13155	
13156	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
13157	
13158	
13159	
13160	
13161	involved in transport factor (ran-gtp, karyopherin)- mediated protein import via the f-g repeat-containing domain which acts as a docking site for substrates. could also have isomerase or chaperone activity and may bind rna or dna. component of the nuclear export pathway. specific docking site for the nuclear export factor exportin-1.
13162	binds dna as a heterodimer with max and represses transcription. binds to the canonical e box sequence 5@#$%&-cacgtg-3@#$%& and, with higher affinity, to 5@#$%&-cacgcg-3@#$%&.
13163	
13164	
13165	palmitoyltransferase specific for vac8. palmitoylates vac8 at one or more of its n-terminal cysteine residues, which is required for its proper membrane localization.
13166	
13167	
13168	
13169	
13170	
13171	
13172	
13173	hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
13174	implicated in immunoproteasome assembly and required for efficient antigen processing. the pa28 activator complex enhances the generation of class i binding peptides by altering the cleavage pattern of the proteasome.
13175	probable immunoglobulin-like cell surface receptor.
13176	
13177	this isozyme may play a role in skeletal mineralization.
13178	
13179	catalyzes the initial reaction in o-linked oligosaccharide biosynthesis, the transfer of an n-acetyl-d- galactosamine residue to a serine or threonine residue on the protein receptor. has a broad spectrum of substrates for peptides such as ea2, muc5ac, muc1a, muc1b. probably involved in o-linked glycosylation of the immunoglobulin a1 (iga1) hinge region.
13180	
13181	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems. g(k) is the stimulatory g protein of receptor- regulated k(+) channels.
13182	bifunctional subunit.
13183	inhibitory regulator of the ras-cyclic amp pathway. binds inositol tetrakisphosphate (ip4).
13184	
13185	histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). in addition, histatins exhibit antibacterial and antifungal activities.
13186	replaces conventional h2a in a subset of nucleosomes. may be involved in the formation of constitutive heterochromatin. may be required for chromosome segregation during cell division.
13187	
13188	
13189	may play a role in cell-cell and cell-matrix interactions. may contribute to various neuronal mechanisms in the central nervous system.
13190	hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
13191	
13192	important modulator in the hla class ii restricted antigen presentation pathway by interaction with the hla-dm molecule.
13193	
13194	
13195	catalyzes the addition of n-acetylglucosamine in beta 1- 6 linkage to the alpha-linked mannose of biantennary n-linked oligosaccharides. it is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.
13196	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
13197	may have an important role in presynaptic function. may be involved in calcium-dependent neurotransmitter release at nerve endings (by similarity).
13198	likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. capable of cleavage at the rx(k/r)r consensus motif.
13199	calcium-dependent mitochondrial solute carrier (by similarity).
13200	could be involved in the hypothalamic regulation of body weight.
13201	
13202	
13203	not known.
13204	sequence-specific transcriptional activator. recognizes the dna sequence 5@#$%&-c[ca]ggaagt-3@#$%&.
13205	hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. does not have reverse activity.
13206	helicase; has atpase activity.
13207	
13208	suppressor of apoptosis.
13209	
13210	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. this receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system. this receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.
13211	
13212	may be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.
13213	
13214	required for proper activation of rho gtpases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via nmda receptors. non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (paf) by removing the acetyl group at the sn-2 position (by similarity). positively regulates the activity of the minus-end directed microtubule motor protein dynein. may enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. required for several dynein- and microtubule-dependent processes such as the maintenace of golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. during nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. may also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.
13215	
13216	
13217	
13218	
13219	recognizes and binds the palindromic sequence 5@#$%&- ttggcnnnnngccaa-3@#$%& present in viral and cellular promoters and in the origin of replication of adenovirus type 2. these proteins are individually capable of activating transcription and replication.
13220	
13221	
13222	may be involved in spermatogenesis.
13223	
13224	
13225	
13226	
13227	may be involved in transcriptional regulation.
13228	
13229	
13230	
13231	
13232	inhibitory effect on stress fiber organization. may down-regulate rho-like gtpase in hematopoietic cells.
13233	
13234	
13235	
13236	
13237	
13238	
13239	
13240	involved in transport of phospholipids (potential).
13241	
13242	
13243	
13244	
13245	
13246	
13247	
13248	
13249	
13250	
13251	
13252	
13253	
13254	this proteoglycan is a major component of extracellular matrix of cartilagenous tissues. a major function of this protein is to resist compression in cartilage. it binds avidly to hyaluronic acid via an n-terminal globular region.
13255	
13256	
13257	
13258	
13259	
13260	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
13261	may be involved in transcriptional regulation.
13262	
13263	
13264	involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. may represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. interacts with the sh2 domain of grb2. may phosphorylate the voltage-gated potassium channel protein kv1.2. its activation is highly correlated with the stimulation of c-jun n-terminal kinase activity.
13265	may act as a gtpase activating protein for rab family protein(s) (potential).
13266	
13267	part of the complex catalyzing the transfer of n- acetylglucosamine from udp-n-acetylglucosamine to phosphatidylinositol, the first step of gpi biosynthesis.
13268	general protein kinase capable of phosphorylating several known proteins.
13269	
13270	
13271	promotes neurite outgrowth of both axons and dendrites (by similarity).
13272	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation via its interaction with the myocyte enhancer factors such as mef2a, mef2c and mef2d.
13273	
13274	
13275	
13276	plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. this phosphodiesterase is highly specific for camp and may have a role in muscle signal transduction.
13277	could be a global transcriptional regulator. modifies gene expression by affecting chromatin. may be involved in brain development and facial morphogenesis.
13278	interacts strongly with cdk4 and cdk6. potent inhibitor. potential effector of tgf-beta induced cell cycle arrest.
13279	
13280	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
13281	
13282	
13283	
13284	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
13285	
13286	activates the small gtpases arf1, arf5 and arf6. regulates the formation of post-golgi vesicles and modulates constitutive secretion. modulates phagocytosis mediated by fc gamma receptor and arf6. modulates pxn recruitment to focal contacts and cell migration.
13287	
13288	probable transcription factor associated with development of alveolar rhabdomyosarcoma.
13289	not known, associated with cell differentiation.
13290	transcriptional repressor that play an important role in the specification and differentiation of lung epithelium.
13291	
13292	
13293	synthesis and degradation of fructose 2,6-bisphosphate.
13294	electroneutral sodium- and bicarbonate-dependent cotransporter with a na(+):hco3(-) 1:1 stoichiometry. regulates intracellular ph and may play a role in bicarbonate salvage in secretory epithelia. may also have an associated sodium channel activity.
13295	muscle contraction.
13296	
13297	serum albumin, the main protein of plasma, has a good binding capacity for water, ca(2+), na(+), k(+), fatty acids, hormones, bilirubin and drugs. its main function is the regulation of the colloidal osmotic pressure of blood.
13298	
13299	
13300	
13301	
13302	
13303	
13304	has antimicrobial activity.
13305	
13306	a rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (erc) to the plasma membrane. also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (ptdinsp3) and phosphatidic acid (pa).
13307	
13308	
13309	
13310	may participate in regulatory interactions between microtubules and the cell cycle.
13311	
13312	
13313	tumor suppressor that may be involved in interferon- dependent cell death (by similarity).
13314	
13315	
13316	receptor for tnfsf2/tnf-alpha and homotrimeric tnfsf1/lymphotoxin-alpha. the adapter molecule fadd recruits caspase-8 to the activated receptor. the resulting death-inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. contributes to the induction of noncytocidal tnf effects including anti-viral state and activation of the acid sphingomyelinase.
13317	
13318	regulates myosin phosphatase activity.
13319	
13320	may be involved in transcriptional regulation.
13321	
13322	
13323	
13324	appears to have dual functions such as cytoplasmic retention of attached nf-kappa-b proteins and generation of p50 by a cotranslational processing. the proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of nfkb1/p105 also appears to occur posttranslationally. p50 binds to the kappa-b consensus sequence 5@#$%&-ggrnnyycc-3@#$%&, located in the enhancer region of genes involved in immune response and acute phase reactions. plays a role in the regulation of apoptosis.
13325	
13326	suppressor of clathrin deficiency.
13327	heterodimers between tcf3 and tissue-specific basic helix-loop-helix (bhlh) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early b-cell differentiation. dimers bind dna on e-box motifs: 5@#$%&- canntg-3@#$%&. binds to the kappa-e2 site in the kappa immunoglobulin gene enhancer.
13328	responsible for the synthesis of complex-type n-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
13329	
13330	
13331	terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. may play a role in regulation of glycine levels in nmda receptor-mediated neurotransmission.
13332	
13333	critical component of the membrane-bound oxidase of phagocytes that generates superoxide. it is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic nadph across the plasma membrane to molecular oxygen on the exterior. also functions as a voltage-gated proton channel that mediates the h(+) currents of resting phagocytes. it participates in the regulation of cellular ph and is blocked by zinc.
13334	binds to the receptor tyrosine kinases ephb1 and epha1. binds to, and induce the collapse of, commissural axons/growth cones in vitro. may play a role in constraining the orientation of longitudinally projecting axons (by similarity).
13335	
13336	major component of the descemet membrane (basement membrane) of corneal endothelial cells.
13337	binds medium- and long-chain acyl-coa esters with very high affinity and may function as an intracellular carrier of acyl-coa esters (by similarity).
13338	
13339	microtubule-binding motor protein probably involved in neuronal axonal transport. in vitro, has a plus-end directed motor activity (by similarity).
13340	could regulate beta-glucan synthesis. overexpression provides resistance to hm-1 killer toxin.
13341	
13342	
13343	
13344	
13345	
13346	
13347	
13348	
13349	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
13350	
13351	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
13352	
13353	regulates the gdp/gtp exchange reaction of the rho proteins by inhibiting the dissociation of gdp from them, and the subsequent binding of gtp to them (by similarity).
13354	
13355	
13356	
13357	
13358	may be involved in transcriptional regulation.
13359	
13360	
13361	
13362	
13363	
13364	
13365	
13366	
13367	
13368	
13369	
13370	
13371	
13372	
13373	
13374	
13375	
13376	
13377	
13378	
13379	
13380	binds to tie2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. its function may be context-dependent. in the absence of angiogenic inducers, such as vegf, ang2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. in concert with vegf, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
13381	
13382	
13383	
13384	may play a role in the specification of neuronal cell types.
13385	
13386	
13387	may act as a regulator of synaptic vesicle exocytosis by controlling the availability of snap25 for the snare complex formation (by similarity).
13388	
13389	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
13390	may be involved in transcriptional regulation.
13391	necessary for the catabolism of n-linked carbohydrates released during glycoprotein turnover. cleaves all known types of alpha-mannosidic linkages.
13392	
13393	
13394	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
13395	
13396	
13397	
13398	binds gtp, gdp and gmp.
13399	trafficking protein from a constitutively recycling pathway (by similarity).
13400	promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including vega-a, vega-c, mmp1, mmp3, timp1, upa, pai-1 and integrins alpha-3 and alpha-5. cyr61-mediated gene regulation is dependent on heparin-binding. down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
13401	
13402	
13403	
13404	
13405	
13406	
13407	type i collagen is a member of group i collagen (fibrillar forming collagen).
13408	regulates intra- and extracellular levels of inorganic pyrophosphate (ppi), probably functioning as ppi transporter.
13409	this protein is a component of ribonucleosomes.
13410	binds to the 23s rrna (by similarity).
13411	
13412	
13413	
13414	
13415	
13416	
13417	
13418	
13419	
13420	
13421	
13422	transcriptional repressor; binds to the dna sequence 5@#$%&- ccggaagt-3@#$%&.
13423	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
13424	
13425	controls reversibly actin polymerization and depolymerization in a ph-sensitive manner. it has the ability to bind g- and f-actin in a 1:1 ratio of cofilin to actin. it is the major component of intranuclear and cytoplasmic actin rods (by similarity).
13426	
13427	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (by similarity).
13428	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&. activates transcription of pf4 in complex with meis1.
13429	
13430	catalyzes the deacetylation of n-acetylaspartic acid (naa) to produce acetate and l-aspartate. naa occurs in high concentration in brain and its hydrolysis naa plays a significant part in the maintenance of intact white matter. in other tissues it act as a scavenger of naa from body fluids.
13431	
13432	
13433	
13434	cell surface proteoglycan that bears heparan sulfate.
13435	subunit of the splicing factor sf3a required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex.
13436	
13437	
13438	
13439	inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the e1 alpha subunit, thus contributing to the regulation of glucose metabolism.
13440	
13441	
13442	probably involved in the repair of mismatches in dna.
13443	
13444	
13445	
13446	
13447	type i collagen is a member of group i collagen (fibrillar forming collagen).
13448	receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5), susceptibility to infection is correlated to its level of expression and availability at the plasma membrane of cells.
13449	
13450	binds to splice sites in pre-mrna and regulates splice site selection. binds and stabilizes cytoplasmic mrna. contributes to the regulation of translation by modulating the interaction between the mrna and eukaryotic initiation factors (by similarity). binds to promoters that contain a y-box (5@#$%&- ctgattggccaa-3@#$%&), such as hla class ii genes. regulates the transcription of numerous genes. promotes separation of dna strands that contain mismatches or are modified by cisplatin. has endonucleolytic activity and can introduce nicks or breaks into double-stranded dna (in vitro). may play a role in dna repair.
13451	
13452	
13453	transcriptional factor which uses the canonical single or multiple carg boxes dna sequence. acts as a cofactor of serum response factor (srf) and has the potential to modulate srf-target genes. suppresses tnf-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. it may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (by similarity).
13454	
13455	binds directly to 26s ribosomal rna (by similarity).
13456	
13457	
13458	
13459	
13460	
13461	
13462	
13463	
13464	
13465	
13466	
13467	
13468	
13469	
13470	
13471	
13472	
13473	
13474	
13475	involved in the biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (moad).
13476	seems to act as a scaffold protein in multiple signaling pathways. modulates excitatory synaptic transmission and dendritic spine morphology. binds to actin filaments (f-actin) and shows cross-linking activity. binds along the sides of the f-actin. may play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. believed to target protein phosphatase 1/pp1 to dendritic spines, which are rich in f-actin, and regulates its specificity toward ion channels and other substrates, such as ampa-type and nmda-type glutamate receptors. plays a role in regulation of g-protein coupled receptor signaling, including dopamine d2 receptors and alpha- adrenergic receptors. may establish a signaling complex for dopaminergic neurotransmission through d2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. binds to adra1b and rgs2 and mediates regulation of adra1b signaling. may confer to rac signaling specificity by binding to both, racgefs and rac effector proteins. probably regulates p70 s6 kinase activity by forming a complex with tiam1.
13477	
13478	
13479	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
13480	neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
13481	involved in the presentation of foreign antigens to the immune system.
13482	plays a role in apoptosis. suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. binding of cytochrome c to apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
13483	sulfate transporter. may play a role in endochondral bone formation.
13484	heparin-binding protein, with mitogenic activity for fibroblasts.
13485	reversible hydration of carbon dioxide. its role in saliva is unknown.
13486	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
13487	
13488	
13489	
13490	
13491	
13492	essential protein involved in the second catalytic step of pre-mrna splicing. involved in the selection of 3@#$%&l-type splice sites; this selection could be done via a 3@#$%& splice site-binding factor, prp16.
13493	
13494	
13495	
13496	may play a role in apoptosis. may act as a tumor suppressor.
13497	core component of nucleosome. nucleosomes wrap and compact dna into chromatin, limiting dna accessibility to the cellular machineries which require dna as a template. histones thereby play a central role in transcription regulation, dna repair, dna replication and chromosomal stability. dna accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodelling.
13498	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
13499	
13500	
13501	
13502	specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
13503	
13504	
13505	
13506	
13507	
13508	low concentration of a soluble form of interleukin-6 receptor acts as an agonist of il6 activity.
13509	
13510	fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
13511	likely to play an important role in intracellular protein and peptide metabolism.
13512	
13513	transcriptional repressor. mad binds with max to form a sequence-specific dna-binding protein complex which recognizes the core sequence 5@#$%&-cac[ga]tg-3@#$%&. mad thus antagonizes myc transcriptional activity by competing for max.
13514	stimulates the kinase activity of stk38 and stk38l.
13515	
13516	
13517	probable scaffold protein that may be involved in mrna transport (potential).
13518	
13519	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
13520	plays a role in the physiological regulation of the intracellular coa concentration (by similarity).
13521	
13522	this is a carcinoma-associated protein, probably a mucin.
13523	cell surface proteoglycan that bears heparan sulfate.
13524	interacts with functionally mature hetero-oligomeric progesterone receptor complexes along with hsp90 and tebp.
13525	one of the major pre-mrna-binding proteins. binds tenaciously to poly(c) sequences. likely to play a role in the nuclear metabolism of hnrnas, particularly for pre-mrnas that contain cytidine-rich sequences. can also bind poly(c) single- stranded dna.
13526	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
13527	
13528	
13529	
13530	component of the sin3-repressing complex. enhances the ability of sin3-hdac1-mediated transcriptional repression. when tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins.
13531	plays a role in valine and pyrimidine metabolism. binds fatty acyl-coa.
13532	
13533	interacts with the e6 protein of the cancer-associated human papillomavirus types 16 and 18. the e6/e6-ap complex binds to and targets the p53 tumor-suppressor protein for ubiquitin- mediated proteolysis. it is an e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. it can target itself for ubiquitination in vitro and efficiently promotes its own degradation in vivo. it appears that only unmodified e6-ap molecules can bind efficiently to p53 in the presence of the hpv e6 oncoprotein.
13534	catalyzes the first committed step in the biosynthesis of complex n-glycans. it controls conversion of high mannose to complex n-glycans; the final hydrolytic step in the n-glycan maturation pathway.
13535	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
13536	
13537	
13538	
13539	dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. could be involved in a signal transduction pathway necessary for late myogenesis, although its ubiquitous expression suggests a wider function.
13540	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
13541	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
13542	
13543	
13544	
13545	involved in translocation of long-chain fatty acids (lfca) across the plasma membrane. the lfca import appears to be hormone-regulated in a tissue-specific manner. in adipocytes, but not myocytes, insulin induces a rapid translocation of fatp1 from intracellular compartments to the plasma membrane, paralleled by increased lfca uptake. may act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. plays a pivotal role in regulating available lfca substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. may be involved in regulation of cholesterol metabolism. has acyl-coa ligase activity for long-chain and very-long-chain fatty acids.
13546	oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
13547	
13548	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
13549	binds to the 5@#$%&stem-loop of u4 snrna and may play a role in the late stage of spliceosome assembly. the protein undergoes a conformational change upon rna-binding.
13550	
13551	
13552	
13553	
13554	
13555	
13556	
13557	
13558	
13559	anticoagulant plasma protein; it is a cofactor to activated protein c in the degradation of coagulation factors va and viiia. it helps to prevent coagulation and stimulating fibrinolysis.
13560	
13561	
13562	
13563	
13564	
13565	
13566	
13567	zinc metalloprotease. exhibits aminopeptidase activity against neurogranin in vitro. does not hydrolyze angiotensin-2.
13568	
13569	
13570	promotes the exchange of ras-bound gdp by gtp. this protein positively controls the level of cellular camp at start, the stage at which the yeast cell division cycle is triggered.
13571	
13572	
13573	
13574	
13575	
13576	
13577	
13578	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
13579	
13580	
13581	
13582	
13583	
13584	
13585	
13586	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2). icam3 is also a ligand for integrin alpha-d/beta-2.
13587	
13588	
13589	
13590	might normally function as a repressor. ews-fusion- proteins (efps) may play a role in the tumorigenic process. they may disturb gene expression by mimicking, or interfering with the normal function of ctd-polii within the transcription initiation complex. they may also contribute to an aberrant activation of the fusion protein target genes.
13591	
13592	
13593	catalyzes the cyclization of (s)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
13594	
13595	
13596	
13597	
13598	
13599	terminal component of the liver microsomal stearyl-coa desaturase system, that utilizes o(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-coa substrates including palmitoyl-coa and stearoyl-coa.
13600	may be involved in transcriptional regulation.
13601	converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an nad-dependent reaction.
13602	
13603	
13604	may play a role in the control of gene expression.
13605	
13606	regulates beta-adrenergic receptor function. beta- arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate g(s) proteins.
13607	intracellular transport of retinol.
13608	protein phosphatase 1 (pp1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. involved in regulation of ionic conductances and long-term synaptic plasticity. may play an important role in dephosphorylating substrates such as the postsynaptic density-associated ca(2+)/calmodulin dependent protein kinase ii.
13609	splice factor that is required for the first atp- dependent step in spliceosome assembly and for the interaction of u2 snrnp with the branchpoint. has weak rna-dependent atpase activity. required for mrna export.
13610	phosphorylates specifically ribosomal protein s6 in response to insulin or several classes of mitogens.
13611	may be involved in transcriptional regulation.
13612	egf stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture.
13613	
13614	may be responsible for potassium buffering action of glial cells in the brain. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. can be blocked by extracellular barium and cesium (by similarity).
13615	regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. confers calcium sensitivity.
13616	collagen type iv is specific for basement membranes.
13617	transfers sialic acid from the donor of substrate cmp- sialic acid to galactose containing acceptor substrates.
13618	
13619	
13620	syntaxin that may be involved in targeting and fusion of golgi-derived retrograde transport vesicles with the er.
13621	
13622	
13623	signal-recognition-particle assembly, binds directly to 7s rna and mediates binding of the 54 kda subunit of the srp.
13624	
13625	h2afx is a basal histone. histones are basic nuclear proteins that are required to maintain the nucleosome structure of the chromosomal fiber in eukaryotes. required for checkpoint- mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of dna double strand breaks (dsbs) specifically when modified by c-terminal phosphorylation.
13626	
13627	
13628	
13629	
13630	
13631	
13632	
13633	
13634	involved in regulating eumelanin and phaeomelanin levels.
13635	
13636	
13637	
13638	
13639	regulatory factor essential for mhc class ii genes expression. binds to the x boxes of mhc class ii genes. also binds to an inverted repeat (enh1) required for hepatitis b virus genes expression and to the most upstream element (alpha) of the rpl30 promoter.
13640	
13641	may facilitate pttg1 nuclear translocation.
13642	
13643	essential for cell viability. taf9 and taf9l are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. may have a role in gene regulation associated with apoptosis. tafs are components of the transcription factor iid (tfiid) complex, the tbp-free tafii complex (tftc), the pcaf histone acetylase complex and the staga transcription coactivator-hat complex. tfiid or tftc are essential for the regulation of rna polymerase ii-mediated transcription (by similarity).
13644	may be involved in cell growth. probably acts as a terminal oxidase of plasma electron transport from cytosolic nad(p)h via hydroquinones to acceptors at the cell surface. hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. the activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
13645	
13646	exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper b into subunit i (by similarity).
13647	the heterodimer with hif1a or epas1/hif2a functions as a transcriptional regulator of the adaptive response to hypoxia.
13648	may participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.
13649	
13650	
13651	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
13652	
13653	receptor for extracellular adenine nucleotides such as atp and adp. in pancreatic islets, may mediate some of the effects of extracellular atp on insulin secretion.
13654	
13655	
13656	
13657	
13658	
13659	
13660	
13661	
13662	stimulates specifically the gtpase activity of ypt6.
13663	
13664	
13665	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
13666	
13667	
13668	possibly acts as a transcriptional regulatory factor.
13669	
13670	
13671	
13672	
13673	
13674	
13675	
13676	
13677	
13678	
13679	
13680	
13681	
13682	
13683	
13684	
13685	
13686	
13687	
13688	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
13689	
13690	
13691	
13692	
13693	
13694	
13695	catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (by similarity).
13696	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems. the g(o) protein function is not clear.
13697	acts as an adapter protein of the fyn and sh2-domain- containing leukocyte protein-76 (slp76) signaling cascades in t cells. modulates the expression of interleukin-2 (il-2).
13698	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
13699	
13700	
13701	central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. together with tom22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the tom40 translocation pore (by similarity).
13702	required for the first step of diphtamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from s-adenosyl-l- methionine to a histidine residue. diphthamide is a post- translational modification of histidine which occurs in elongation factor 2.
13703	
13704	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
13705	
13706	
13707	
13708	catalyzes the removal of sialic acid (n-acetylneuramic acid) moities from glycoproteins and glycolipids. to be active, it is strictly dependent on its presence in the multienzyme complex. appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
13709	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
13710	
13711	
13712	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the complex p170-eif3.
13713	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
13714	may play a role in promoting maturation and morphological differentiation of cerebellar neurons.
13715	converts inositol hexakisphosphate (insp6) to diphosphoinositol pentakisphosphate (insp7/pp-insp5). converts 1,3,4,5,6-pentakisphosphate (insp5) to pp-insp4.
13716	implicated in tumor cell metastasis. may function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction.
13717	
13718	converts big endothelin-1 to endothelin-1.
13719	
13720	
13721	
13722	
13723	interacts with mapk kinases and regulates activation of map kinases. does not display kinase activity (by similarity).
13724	involved in cell wall synthesis where it is required for glycosylation. involved in cell cycle progression through cell- size checkpoint.
13725	binds to actin and affects the structure of the cytoskeleton. at high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. by binding to pip2, it inhibits the formation of ip3 and dg.
13726	catalytic subunit of the peripheral v1 complex of vacuolar atpase. v-atpase vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
13727	associates with cyclin g and cdk5. seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by hsc70 in non-neuronal cells. expression oscillates slightly during the cell cycle, peaking at g1.
13728	
13729	
13730	involved with pre-mrna processing. forms complexes (ribonucleosomes) with at least 20 other different hnrnp and heterogeneous nuclear rna in the nucleous.
13731	signal-transducing molecule. may have a common pathway with il6st. the soluble form inhibits the biological activity of lif by blocking its binding to receptors on target cells.
13732	branching enzyme that converts linear into branched poly-n-acetyllactosaminoglycans. introduces the blood group i antigen during embryonic development. it is closely associated with the development and maturation of erythroid cells.
13733	tubulin-folding protein; involved in the final step of the tubulin folding pathway.
13734	may function as part of a signaling pathway that acts to regulate the size of the body fat depot. an increase in the level of lep may act directly or indirectly on the cns to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
13735	
13736	
13737	acts as a gtpase activating protein for rab5a. involved in receptor trafficking. in complex with eps8 inhibits internalization of egfr.
13738	binds to actin and plays an important role in the assembly of the z-disk.
13739	actin cross-linking/gelling protein (by similarity). involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
13740	secretory vesicle-specific electron transport protein.
13741	the insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.
13742	excises uracil residues from the dna which can arise as a result of misincorporation of dump residues by dna polymerase or due to deamination of cytosine.
13743	
13744	
13745	catalyzes the hydrolysis of gtp bound to the 40s ribosomal initiation complex (40s.mrna.met-trna[f].eif-2.gtp) with the subsequent joining of a 60s ribosomal subunit resulting in the release of eif-2 and the guanine nucleotide. the subsequent joining of a 60s ribosomal subunit results in the formation of a functional 80s initiation complex (80s.mrna.met-trna[f]).
13746	component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. the nua4 complex atpase and helicase activities seem to be, at least in part, contributed by the association of ruvbl1 and ruvbl2 with ep400. nua4 may also play a direct role in dna repair when directly recruited to sites of dna damage. also component of the msin3a complex which acts to repress transcription by deacetylation of nucleosomal histones.
13747	
13748	overproduction suppresses the slow growth phenotype of cpr7 mutant cells.
13749	rab effector protein acting as linker between gamma- adaptin, rab4a and rab5a. involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. stimulates rabgef1 mediated nucleotide exchange on rab5a.
13750	may be involved in transcriptional regulation.
13751	
13752	collagen type iv is specific for basement membranes.
13753	may function as a cell-type specific modulator for g protein-mediated cell signaling.
13754	
13755	may act in the sexual differentiation pathway (by similarity).
13756	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. isoform alpha-1i gives rise to t-type calcium currents. t-type calcium channels belong to the @#$%!low-voltage activated (lva)@#$%! group and are strongly blocked by nickel and mibefradil. a particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. t-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. they may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. gates in voltage ranges similar to, but higher than alpha 1g or alpha 1h (by similarity).
13757	
13758	
13759	
13760	may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
13761	
13762	
13763	
13764	
13765	
13766	
13767	this protein is a component of ribonucleosomes. could be needed to organize a concentration gradient of a dorsalizing morphogen (dm) originating in the germinal vesicle. at least one of the isoforms is essential in somatic tissues.
13768	
13769	
13770	
13771	
13772	
13773	
13774	
13775	implicated in the suppression of cell death. interacts with the bcl-2 and adenovirus e1b 19 kda proteins (by similarity).
13776	
13777	
13778	
13779	
13780	
13781	
13782	
13783	
13784	
13785	
13786	
13787	
13788	
13789	
13790	major glycoprotein of vascular endothelium. may play a critical role in the binding of endothelial cells to integrins and/or other rgd receptors.
13791	
13792	
13793	
13794	
13795	
13796	muscle contraction.
13797	
13798	required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.
13799	
13800	the classic group of mbp isoforms (isoform 4-isoform 14) are with plp the most abundant protein components of the myelin membrane in the cns. they have a role in both its formation and stabilization. the smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. the non- classic group of mbp isoforms (isoform 1-isoform 3/golli-mbps) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in t- cells and neural cells. differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.
13801	
13802	
13803	associated with the mammalian reproductive process. catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
13804	collagen type iii occurs in most soft connective tissues along with type i collagen.
13805	
13806	
13807	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
13808	
13809	
13810	
13811	may be involved in transcriptional regulation as a repressor. candidate gene for wolf-hirschhorn (4p-) syndrome (whs).
13812	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase c. it could help neuronal cells to establish short- term memory.
13813	
13814	
13815	
13816	
13817	potential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes.
13818	
13819	
13820	exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper b into subunit i (by similarity).
13821	
13822	
13823	may constitute a novel regulatory system for basal transcription. negatively regulates abt1 (by similarity).
13824	
13825	
13826	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
13827	
13828	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of calcium out of the cell.
13829	protein phosphatase (pp1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. involved in regulation of ionic conductances and long-term synaptic plasticity.
13830	
13831	
13832	
13833	receptor for steroids (potential).
13834	actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (by similarity).
13835	
13836	transports cmp-sialic acid from the cytosol into golgi vesicles where glycosyltransferases function.
13837	
13838	responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. plays a role in the regulation of protein translation by phosphorylating and inactivating eef2k.
13839	
13840	cytokine that inhibits the activity of bmp2 and bmp4 in a dose-dependent manner. antagonized bmp4-induced suppression of progesterone production in granulosa cells (by similarity).
13841	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
13842	
13843	mediates estrogen action in various target organs.
13844	
13845	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
13846	involved in dna excision repair. may play a part in dna damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes.
13847	catalyzes the posttranslational formation of 4- hydroxyproline in -xaa-pro-gly- sequences in collagens and other proteins.
13848	
13849	
13850	
13851	
13852	
13853	involved in repair of uv radiation-induced dna damage. catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same dna strand upon exposure to ultraviolet radiation.
13854	
13855	
13856	this is a receptor for the anterior pituitary hormone prolactin.
13857	
13858	
13859	
13860	functions as a component of the nuclear pore complex (npc). npc components, collectively referred to as nucleoporins (nups), can play the role of both npc structural components and of docking or interaction partners for transiently associated nuclear transport factors. involved in nuclear poly(a)+ rna export and npc biogenesis, it is also required for normal nuclear morphology.
13861	
13862	binds specifically to phosphatidylinositol-3-phosphate (ptdins3p), but not to other phosphoinositides.
13863	binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate.
13864	
13865	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
13866	involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. activates rac1 and rac2 small gtpases, probably by functioning as a guanine nucleotide exchange factor (gef), which exchanges bound gdp for free gtp. may also participate in il2 transcriptional activation via the activation of rac2.
13867	catalyzes the initial reaction in o-linked oligosaccharide biosynthesis, the transfer of an n-acetyl-d- galactosamine residue to a serine or threonine residue on the protein receptor. has activity toward ea2 peptide substrate, but has a weak activity toward muc2 or muc1b substrates (by similarity).
13868	
13869	catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of nad. it is the rate limiting component in the mammalian nad biosynthesis pathway (by similarity).
13870	
13871	type i collagen is a member of group i collagen (fibrillar forming collagen).
13872	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
13873	
13874	
13875	binds to isre-like element (interferon-stimulated response element) of myc p2 promoter.
13876	
13877	
13878	aminopeptidase with broad substrate specificity to several peptides. involved in proteolytic events essential for cell growth and viability. may act as regulator of neuropeptide activity (by similarity).
13879	
13880	
13881	
13882	
13883	
13884	
13885	the jnk-interacting protein (jip) group of scaffold proteins selectively mediates jnk signaling by aggregating specific components of the mapk cascade to form a functional jnk signaling module. required for jnk activation in response to excitotoxic stress. cytoplasmic mapk8ip1 causes inhibition of jnk- regulated activity by retaining jnk in the cytoplasm and inhibiting jnk phosphorylation of c-jun. may also participate in apoer2-specific reelin signaling. directly, or indirectly, regulates glut2 gene expression and beta-cell function. appears to have a role in cell signaling in mature and developing nerve terminals. may function as a regulator of vesicle transport, through interactions with the jnk-signaling components and motor proteins (by similarity). functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.
13886	
13887	may be involved in transcriptional regulation.
13888	
13889	
13890	
13891	
13892	
13893	binds to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation. inhibits the phosphorylation of nucleosomal histones h3 and h2a by rps6ka5/msk1 and rps6ka3/rsk2 (by similarity).
13894	
13895	
13896	
13897	
13898	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
13899	
13900	
13901	
13902	
13903	collagen type iv is specific for basement membranes.
13904	
13905	
13906	
13907	
13908	
13909	
13910	could regulate beta-glucan synthesis. overexpression provides resistance to hm-1 killer toxin.
13911	
13912	
13913	
13914	tyrosine kinase of the non-receptor type, involved in the ifn-alpha/beta/gamma signal pathway. kinase partner for the interleukin (il)-2 receptor.
13915	
13916	
13917	could regulate beta-glucan synthesis. overexpression provides resistance to hm-1 killer toxin.
13918	promotes the exchange of gdp by gtp (by similarity).
13919	may function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins.
13920	probably involved in the repair of mismatches in dna.
13921	functions as a myeloid and b-cell proto-oncogene. may play important roles in leukemogenesis and hematopoiesis. an essential factor in lymphopoiesis, is required for b-cell formation in fetal liver. may function as a modulator of the transcriptional repression activity of arp1 (by similarity).
13922	
13923	
13924	
13925	
13926	
13927	mediates ubiquitination of cellular proteins.
13928	
13929	chemoattractant active on t-lymphocytes, monocytes, but not neutrophils. sdf-1-beta(3-72) and sdf-1-alpha(3-67) show a reduced chemotactic activity. binding to cell surface proteoglycans seems to inhibit formation of sdf-1-alpha(3-67) and thus to preserve activity on local sites.
13930	
13931	
13932	
13933	
13934	serine protease. hydrolyzes the peptides n-t-boc-gln- ala-arg-amc and n-t-boc-gln-gly-arg-amc and, to a lesser extent, n-t-boc-ala-phe-lys-amc and n-t-boc-val-leu-lys-amc. has a preference for substrates with an arg instead of a lys residue in position p1.
13935	
13936	
13937	dna- and rna binding protein, involved in several nuclear processes. binds the conventional octamer sequence in double stranded dna. also binds single-stranded dna and rna at a site independent of the duplex site (by similarity). involved in pre-mrna splicing, probably as an heterodimer with sfpq. interacts with u5 snrna, probably by binding to a purine-rich sequence located on the 3@#$%& side of u5 snrna stem 1b. the sfpq-nono heteromer associated with matr3 may play a role in nuclear retention of defective rnas. the sfpq-nono heteromer may be involved in dna unwinding by modulating the function of topoisomerase i/top1. the sfpq-nono heteromer may be involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination and may stabilize paired dna ends. in vitro, the complex strongly stimulates dna end joining, binds directly to the dna substrates and cooperates with the ku70/g22p1-ku80/xrcc5 (ku) dimer to establish a functional preligation complex. nono is involved in transcriptional regulation. the sfpq-nono-nr5a1/sf-1 complex binds to the cyp17 promoter and regulates basal and camp-dependent transcriptional avtivity. nono binds to an enhancer element in long terminal repeats of endogenous intracisternal a particles (iaps) and activates transcription (by similarity).
13938	participates in the apoptotic response to dna damage. when overproduced, activates transcription from p53-responsive promoters and induces apoptosis. may be a tumor suppressor protein.
13939	synthesis and degradation of fructose 2,6-bisphosphate.
13940	could act as a core histone necessary for the assembly of centromeres. may replace one or both copies of histone h3 in a certain set of centromeric nucleosomes.
13941	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
13942	
13943	may be involved in regulating membrane traffic to and from trans-golgi network.
13944	
13945	can stimulate e2f-dependent transcription. binds dna cooperatively with e2f family members through the e2 recognition site, 5@#$%&-tttc[cg]cgc-3@#$%&, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the dp2/e2f complex functions in the control of cell-cycle progression from g1 to s phase. the e2f-1/dp complex appears to mediate both cell proliferation and apoptosis.
13946	dna repair enzyme that incises dna at 8-oxog residues. excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-n- methylformamidopyrimidine (fapy) from damaged dna. has a beta- lyase activity that nicks dna 3@#$%& to the lesion.
13947	
13948	
13949	calcium-dependent, calmodulin-stimulated protein phosphatase. this subunit may have a role in the calmodulin activation of calcineurin. dephosphorylates hspb1 and ssh1.
13950	
13951	plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. exerts it highest activity toward 3-hydroxybutyryl-coa.
13952	
13953	
13954	may play a role during cellular proliferation and c-myc- mediated transformation (by similarity).
13955	associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mrna splicing.
13956	phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
13957	
13958	
13959	probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. may act as a tumor suppressor.
13960	
13961	negatively regulates matrix metalloproteinase-9 (mmp-9) by suppressing mmp-9 secretion and by direct inhibition of its enzymatic activity. reck down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. appears to also regulate mmp-2 and mt1-mmp, which are involved in cancer progression.
13962	
13963	
13964	
13965	
13966	replaces conventional h2a in a subset of nucleosomes. may be involved in the formation of constitutive heterochromatin. may be required for chromosome segregation during cell division.
13967	
13968	catalyzes the hydrolysis of gtp bound to the 40s ribosomal initiation complex (40s.mrna.met-trna[f].eif-2.gtp) with the subsequent joining of a 60s ribosomal subunit resulting in the release of eif-2 and the guanine nucleotide. the subsequent joining of a 60s ribosomal subunit results in the formation of a functional 80s initiation complex (80s.mrna.met-trna[f]).
13969	
13970	
13971	may have a function in cell cycle regulation. binds to and may be involved in the transforming capacity of the adenovirus e1a protein. may act as a tumor suppressor. potent inhibitor of e2f-mediated trans-activation, associates preferentially with e2f5. binds to cyclins a and e.
13972	this is a membrane-bound, calcium-inhibitable adenylyl cyclase.
13973	clathrin is the major protein of the polyhedral coat of coated pits and vesicles. two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-golgi network.
13974	
13975	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
13976	required for protein import into peroxisomes.
13977	
13978	
13979	suggested to be involved in kindling epileptogenesis and hippocampal plasticity. has a strong proteolytic activity against fibronectin (by similarity).
13980	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2). icam3 is also a ligand for integrin alpha-d/beta-2.
13981	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2). icam3 is also a ligand for integrin alpha-d/beta-2.
13982	acts as dominant repressor towards other family members. inhibits nf-kappa-b-regulated gene expression. may be required for the initiation and maintenance of the differentiated state.
13983	
13984	
13985	involved in protein-protein interactions at adherens junctions.
13986	
13987	receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-coa oxidase and activates its transcription. it therefore controls the peroxisomal beta-oxidation pathway of fatty acids.
13988	
13989	
13990	
13991	
13992	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
13993	
13994	
13995	
13996	
13997	
13998	essential component of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. when overexpressed in cells induces the formation of cytoplasmic annulate lamellae (al) (by similarity).
13999	
14000	
14001	
14002	gtpase-activating protein (gap) for arf1 and arf5, which also shows strong gtpase activity. isoform 1 participates to the prevention of neuronal apoptosis by enhancing pi3 kinase activity. it aids the coupling of metabotropic glutamate receptor 1 (grm1) to cytoplasmic pi3 kinase by interacting with homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of ngf by activating nuclear pi3 kinase. isoform 2 does not stimulate pi3 kinase but may protect cells from apoptosis by stimulating akt. it also regulates the adapter protein 1 (ap-1)-dependent trafficking of proteins in the endosomal system.
14003	type i collagen is a member of group i collagen (fibrillar forming collagen).
14004	
14005	
14006	
14007	involved in the presentation of foreign antigens to the immune system.
14008	
14009	
14010	
14011	
14012	this protein is associated with sn-rnp u2. it helps the a@#$%& protein to bind stem loop iv of u2 snrna (by similarity).
14013	
14014	
14015	
14016	
14017	
14018	
14019	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules (by similarity).
14020	
14021	
14022	
14023	
14024	promotes the exchange of ras-bound gdp by gtp.
14025	ca(2+)-regulated actin-binding protein.
14026	
14027	transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. binds dna on the 5@#$%&-ccac[ga]-3@#$%&half of the er stress response element (erse) (5@#$%&-ccaat-n(9)-ccac[ga]-3@#$%&) and of erse ii (5@#$%&-attgg-n-ccacg-3@#$%&). binding to erse requires binding of nf-y to erse. could also be involved in activation of transcription by the serum response factor.
14028	this protein is essential for differentiation. it may play a role in localizing of nanos (a maternal determinant) activity in oocytes. bicd mutations cause nanos mislocalization and thus bicaudal development.
14029	not known, could be a tyrosine-phosphatase.
14030	inhibitory regulator of the ras-cyclic amp pathway.
14031	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
14032	
14033	
14034	
14035	
14036	
14037	
14038	
14039	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. l is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes.
14040	
14041	
14042	
14043	general activator of rna polymerase iii transcription.
14044	
14045	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l.
14046	functions in post-golgi recycling pathways. acts as a recycling carrier to the cell surface.
14047	plays a role in transcriptional coactivation.
14048	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
14049	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
14050	binds to the intracellular domain of tumor necrosis factor type 1 receptor. the binding domain of trap1 and trap2 resides outside the death domain of tnfr1.
14051	may be involved in vesicular trafficking and neurotransmitter release.
14052	
14053	may function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding mad2l1 after it has become dissociated from the mad2l1-cdc20 complex.
14054	
14055	
14056	
14057	
14058	
14059	
14060	
14061	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
14062	
14063	
14064	
14065	presumably involved in the processing and regular turnover of intracellular proteins. catalyzes the removal of unsubstituted n-terminal amino acids from various peptides.
14066	
14067	
14068	
14069	
14070	participates in processes of transmission and amplification of the visual signal. cgmp-pdes are the effector molecules in g-protein-mediated phototransduction in vertebrate rods and cones.
14071	
14072	
14073	
14074	may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. in association with the sfpq-nono heteromer may play a role in nuclear retention of defective rnas.
14075	
14076	
14077	
14078	
14079	binds gtp, gdp and gmp.
14080	
14081	chemotactic activity for lymphocytes but not for monocytes or neutrophils.
14082	
14083	
14084	
14085	highly potent vasoconstrictor.
14086	
14087	
14088	
14089	
14090	may play a role in transcriptional regulation. binds to and activates cyclin-dependent kinase cdk8 that phosphorylates the ctd (carboxy-terminal domain) of the large subunit of rna polymerase ii (rnap ii).
14091	
14092	
14093	
14094	may function in pre-mrna splicing.
14095	
14096	required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.
14097	
14098	
14099	
14100	involved in iron cellular uptake. seems to be internalized and then recycled back to the cell membrane. binds a single atom of iron per subunit. could also bind zinc.
14101	
14102	
14103	
14104	receptor for the c-x-c chemokine cxcl16. used as a coreceptor by sivs and by strains of hiv-2 and m-tropic hiv-1.
14105	transcriptional repressor that play an important role in the specification and differentiation of lung epithelium.
14106	
14107	
14108	
14109	
14110	
14111	
14112	
14113	
14114	
14115	
14116	
14117	activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (apc/c). during telophase and in the subsequent g1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (d-box) and an additional degradation signal termed the ken box including ase1, cdc20, the b-type cyclins clb2 and clb3, the polo-like kinase cdc5 and hsl1, and recruits them in a c-box-dependent manner to the apc/c for ubiquitination and subsequent proteolysis. required for exit from mitosis, cytokinesis and formation of prereplicative complexes in g1. probably is the target of a bub2-dependent spindle checkpoint pathway.
14118	
14119	
14120	involved in pre-mrna splicing. facilitates the cooperative formation of u2/u6 helix ii in association with stem ii in the spliceosome. binds to rna.
14121	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
14122	
14123	
14124	
14125	thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity. coactivates six1, and seems to coactivate six2, six4 and six5. the repression of precursor cell proliferation in myoblasts by six1 is switched to activation through recruitment of eya3 to the six1-dach1 complex and seems to be dependent on eya3 phosphatase activity (by similarity). may be involved in development of the eye.
14126	
14127	
14128	probably plays a role in anchoring the complex to other cellular components.
14129	
14130	
14131	
14132	
14133	
14134	probable transcriptional activator in the premeiotic germ cells. it binds to the sequences 5@#$%&-aacaat-@#$%&3 or 5@#$%&-aacaaag- 3@#$%& (by similarity).
14135	
14136	
14137	
14138	demethylates proteins that have been reversibly carboxymethylated. demethylates ppp2cb (in vitro).
14139	
14140	
14141	
14142	involved in cell adhesion. may be involved in the attachment of the actin-based microfilaments to the plasma membrane.
14143	
14144	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
14145	initiates the extrinsic pathway of blood coagulation. serine protease that circulates in the blood in a zymogen form. factor vii is converted to factor viia by factor xa, factor xiia, factor ixa, or thrombin by minor proteolysis. in the presence of tissue factor and calcium ions, factor viia then converts factor x to factor xa by limited proteolysis. factor viia will also convert factor ix to factor ixa in the presence of tissue factor and calcium (by similarity).
14146	
14147	
14148	
14149	seems to have a role in retrograde membrane traffic at the level of the golgi complex.
14150	enhances ar-mediated transactivation. transactivation decreases as the poly-gln length within ar increases.
14151	
14152	
14153	
14154	acts as a positive regulator of apoptosis.
14155	
14156	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
14157	essential component of the scf (skp1-cul1-f-box protein) e3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. in the scf complex, serves as a rigid scaffold that organizes the skp1-f-box protein and rbx1 subunits. may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
14158	
14159	
14160	
14161	
14162	
14163	differentially targeted protein that binds to type i and ii regulatory subunits of protein kinase a and anchors them to the mitochondria or the plasma membrane. although the physiological relevance between pka and akaps with mitochondria is not fully understood, one idea is that bad, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored pka. it cannot be excluded too that it may facilitate pka as well as g protein signal transduction, by acting as an adapter for assembling multiprotein complexes. with its rgs domain, it could lead to the interaction to g-alpha proteins, providing a link between the signaling machinery and the downstream kinase (by similarity).
14164	
14165	
14166	
14167	
14168	
14169	
14170	
14171	
14172	splicing factor that in its dephosphorylated form acts as a general repressor of pre-mrna splicing. seems to interfere with the u1 snrnp 5@#$%&-splice recognition of snrp70. required for splicing repression in m-phase cells and after heat shock. may be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
14173	
14174	
14175	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
14176	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. socs1 is involved in negative regulation of cytokines that signal through the jak/stat3 pathway. through binding to jaks, inhibits their kinase activity. in vitro, also suppresses tec protein- tyrosine activity. appears to be a major regulator of signaling by interleukin 6 (il6) and leukemia inhibitory factor (lif). regulates interferon-gamma mediated sensory neuron survival (by similarity). implicated, through socs box binding, in ubiquitin- dependent protein degradation.
14177	
14178	
14179	
14180	
14181	belongs to the exosome, a rna-processing complex, which is at least involved in the 3@#$%& processing of the 7s pre-rrna to the mature 5.8s rrna. exhibits a 3@#$%&-5@#$%& exoribonuclease activity (by similarity).
14182	
14183	involved in axon growth. plays an essential role in neurite extension of cerebellar granule cells.
14184	
14185	hydrolysis of the deoxyribose n-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged dna polymer formed by alkylation lesions.
14186	it may be responsible for the synthesis of the sequence neuac-alpha-2,3-gal-beta-1,3-galnac- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. siat4a and siat4b sialylate the same acceptor substrates but exhibit different km values.
14187	
14188	
14189	
14190	
14191	
14192	
14193	
14194	
14195	may be involved in retrograde transport of early and late endosomes to the late golgi.
14196	promotes infectivity of neisseria gonorrhoeae in epithelial cells by phosphorylating mcp/cd46.
14197	
14198	
14199	
14200	
14201	
14202	this protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.
14203	functions as an e3-type small ubiquitin-like modifier (sumo) ligase, stabilizing the interaction between ube2i and the substrate, and as a sumo-tethering factor. plays a crucial role as a transcriptional coregulation in various cellular pathways, including the stat pathway, the p53 pathway, the wnt pathway and the steroid hormone signaling pathway. involved in gene silencing.
14204	
14205	catalyzes the isomerization of prostaglandin h2 to prostacyclin (= prostaglandin i2).
14206	
14207	
14208	
14209	
14210	plays a role in cytoplasmic trafficking of rna. binds to the cis-acting response element, a2re.
14211	plays a role in cytoplasmic trafficking of rna. binds to the cis-acting response element, a2re.
14212	
14213	
14214	
14215	
14216	collagen type iii occurs in most soft connective tissues along with type i collagen.
14217	
14218	
14219	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein.
14220	
14221	
14222	
14223	may play a structural role at sites of cell adhesion in maintaining cell shape and motility. in addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. may be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
14224	collagen type iv is specific for basement membranes.
14225	
14226	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
14227	
14228	
14229	
14230	
14231	
14232	
14233	
14234	
14235	
14236	
14237	
14238	
14239	
14240	
14241	
14242	
14243	
14244	
14245	
14246	
14247	phosphorylates specifically ribosomal protein s6 in response to insulin or several classes of mitogens.
14248	
14249	
14250	
14251	
14252	
14253	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. probably binds g- rich sequences in pre-mrnas.
14254	
14255	
14256	
14257	
14258	
14259	protein kinase acting as a corepressor of several transcription factors, including smad1 and pou4f1/brn3a and probably nk homeodomain transcription factors. inhibits cell growth and promotes apoptosis. involved in transcriptional activation of tp53 and tp73. phosphorylation of tp53 may be mediated by a tp53-hipk2-axin1 complex. in response to tgfb, cooperates with daxx to activate jnk. phosphorylates the antiapoptotic factor ctbp1 and promotes its proteasomal degradation. in the wnt/beta-catenin signaling pathway acts as an intermediate kinase between tak1 and nlk to promote the proteasomal degradation of c-myb (by similarity).
14260	
14261	this small ubiquitous enzyme is essential for maintenance and cell growth.
14262	
14263	
14264	
14265	
14266	
14267	
14268	
14269	plays a critical role in catalyzing the release of class ii hla-associated invariant chain-derived peptides (clip) from newly synthesized class ii hla molecules and freeing the peptide binding site for acquisition of antigenic peptides.
14270	
14271	
14272	
14273	
14274	
14275	
14276	collagen type iii occurs in most soft connective tissues along with type i collagen.
14277	
14278	
14279	
14280	
14281	
14282	associated with snrnp u1, u2, u4/u6 and u5.
14283	binds the telomeric double-stranded ttaggg repeat and negatively regulates telomere length. involved in the regulation of the mitotic spindle.
14284	
14285	
14286	
14287	
14288	
14289	
14290	
14291	
14292	
14293	
14294	
14295	
14296	
14297	
14298	
14299	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
14300	
14301	high affinity receptor for semaphorins 3c, 3f, vegf-165 and vegf-145 isoforms of vegf, and the plgf-2 isoform of pgf.
14302	
14303	
14304	
14305	
14306	
14307	probably involved in cell adhesion. receptor for alphaherpesvirus (hsv-1, hsv-2 and pseudorabies virus) entry into cells.
14308	
14309	
14310	
14311	
14312	
14313	
14314	the soluble isoform 2 binds vegf-165 and appears to inhibit its binding to cells. it may also induce apoptosis by sequestering vegf-165. may bind as well various members of the semaphorin family. its expression has an averse effect on blood vessel number and integrity.
14315	
14316	
14317	
14318	
14319	
14320	aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
14321	
14322	rna-binding protein. required for internal initiation of translation of human rhinovirus rna. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain.
14323	
14324	
14325	
14326	
14327	
14328	
14329	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
14330	
14331	
14332	the 3beta-hsd enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. hsd vii is active against four 7alpha-hydroxylated sterols. does not metabolize several different c(19/21) steroids as substrates. involved in bile acid synthesis.
14333	
14334	
14335	
14336	
14337	
14338	may be involved in autophagy-related processes (by similarity).
14339	
14340	
14341	
14342	
14343	
14344	
14345	
14346	
14347	
14348	
14349	
14350	
14351	
14352	
14353	binds to activated (phosphorylated) protein-tyrosine kinases through its sh2 domain and regulates their kinase activity. during insulin stimulation, it also binds to irs-1.
14354	
14355	activates apoptosis and interacts selectively with survival-promoting proteins bcl-2 and bcl-x(l).
14356	
14357	
14358	
14359	
14360	the electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- coa dehydrogenases, glutaryl-coa and sarcosine dehydrogenase. it transfers the electrons to the main mitochondrial respiratory chain via etf-ubiquinone oxidoreductase (etf dehydrogenase).
14361	
14362	
14363	
14364	
14365	e3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by map3k3. potentiates mekk3-mediated activation of the nf-kappa-b, jun/ap1 and ddit3 transcriptional regulators. induces apoptosis when overexpressed.
14366	
14367	
14368	protein kinase that act on both serine and threonine residues.
14369	binds to the camp response element and activates transcription.
14370	
14371	
14372	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
14373	
14374	
14375	
14376	
14377	
14378	
14379	
14380	complex that is thought to mediate chromatin assembly in dna replication and dna repair. assembles histone octamers onto replicating dna in vitro. caf-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones h3 and h4 to replicating dna; histones h2a/h2b can bind to this chromatin precursor subsequent to dna replication to complete the histone octamer. chaf1a binds to histones h3 and h4. it may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic dna replication foci (by similarity). the ccr4-not complex functions as general transcription regulation complex.
14381	may have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor.
14382	
14383	type i collagen is a member of group i collagen (fibrillar forming collagen).
14384	involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. may play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. low-affinity receptor for agouti (by similarity). has a critical role in normal myelination in the central nervous system (by similarity).
14385	
14386	
14387	
14388	
14389	may play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. required for sperm motility and male fertility (by similarity).
14390	
14391	
14392	
14393	
14394	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. combines rna-binding and ppiase activities. may be involved in muscle- and brain-specific processes.
14395	may be required for dna interstrand cross-link repair.
14396	
14397	
14398	
14399	cytokine that binds to tnfrsf6/fas, a receptor that transduces the apoptotic signal into cells. may be involved in cytotoxic t-cell mediated apoptosis and in t-cell development. tnfrsf6/fas-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature t-cells, or both. binding to the decoy receptor tnfrsf6b/dcr3 modulates its effects.
14400	
14401	prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
14402	
14403	promotes the exchange of ras-bound gdp by gtp. this protein positively controls the level of cellular camp at start, the stage at which the yeast cell division cycle is triggered.
14404	
14405	
14406	
14407	
14408	
14409	
14410	required for the uptake of taurine.
14411	
14412	subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-golgi network (tgn) to the endosomal-lysosomal system.
14413	
14414	
14415	required for neural tube formation. essential for normal heart development and function. acts as a transcriptional repressor of anf by binding to both gata4 and nkx2-5 and repressing their transcriptional activator activities. participates in the negative regulation of cell proliferation signaling (by similarity).
14416	
14417	
14418	
14419	
14420	
14421	may act as a lysosomal receptor.
14422	
14423	
14424	
14425	
14426	protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function.
14427	
14428	
14429	this is a receptor for retinoic acid. this metabolite has profound effects on vertebrate development. retinoic acid is a morphogen and is a powerful teratogen. this receptor controls cell function by directly regulating gene expression.
14430	
14431	
14432	
14433	
14434	
14435	
14436	
14437	
14438	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell. may play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.
14439	
14440	
14441	
14442	
14443	
14444	
14445	may act as a tumor suppressor.
14446	
14447	attaches integral membrane proteins to cytoskeletal elements. also binds to cytoskeletal proteins. required for coordinate assembly of na/ca exchanger, na/k atpase and insp3 receptor at sarcoplasmic reticulum sites in cardiomyocytes.
14448	
14449	
14450	
14451	
14452	
14453	
14454	
14455	
14456	
14457	
14458	
14459	
14460	
14461	
14462	
14463	
14464	
14465	
14466	
14467	
14468	
14469	
14470	may function in membrane trafficking. exhibits calcium- dependent phospholipid binding properties (by similarity).
14471	regulates myosin phosphatase activity.
14472	
14473	collagen type iv is specific for basement membranes.
14474	binds to cug triplet repeat expansion dsrna (by similarity).
14475	
14476	functions as a master transcriptional regulator of the adaptive response to hypoxia. under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. binds to core dna sequence 5@#$%&-[ag]cgtg-3@#$%& within the hypoxia response element (hre) of target gene promoters. activation requires recruitment of transcriptional coactivators such as crebpb and ep300. activity is enhanced by interaction with both, ncoa1 or ncoa2. interaction with redox regulatory protein apex seems to activate ctad and potentiates activation by ncoa1 and crebbp.
14477	
14478	thiol protease which is believed to participate in intracellular degradation and turnover of proteins. has also been implicated in tumor invasion and metastasis.
14479	
14480	
14481	catalyzes the irreversible nadph-dependent deamination of gmp to imp. it functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of g to a nucleotides, and in maintaining the intracellular balance of a and g nucleotides. plays a role in modulating cellular differentiation.
14482	
14483	may be a mediator of metastasis suppression in breast carcinoma (by similarity).
14484	
14485	
14486	
14487	
14488	
14489	
14490	
14491	
14492	produces nitric oxide (no) which is a messenger molecule with diverse functions throughout the body. in macrophages, no mediates tumoricidal and bactericidal actions.
14493	may be involved in transcriptional regulation.
14494	
14495	drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. may also be linked to the malignant phenotype.
14496	
14497	
14498	
14499	
14500	favors the reduction of estrogens and androgens. also has 20-alpha-hsd activity. uses preferentially nadh.
14501	
14502	
14503	
14504	
14505	inhibits primary neurogenesis. may be required to divert neurons along a specific differentiation pathway. plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (by similarity).
14506	
14507	
14508	
14509	
14510	
14511	
14512	adenosylhomocysteine is a competitive inhibitor of s- adenosyl-l-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
14513	
14514	
14515	
14516	
14517	
14518	receptor for vegf, vegfb and pgf. has a tyrosine-protein kinase activity. the vegf-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. isoform sflt1 may have an inhibitory role in angiogenesis.
14519	cell surface proteoglycan that bears heparan sulfate. may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. may play a role in the modulation of igf2 interactions with its receptor and thereby modulate its function. may regulate growth and tumor predisposition.
14520	
14521	l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists. this receptor binds kainate > quisqualate = glutamate >> ampa.
14522	essential component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. recruits mitochondrial hsp70 to drive protein translocation into the matrix using atp as an energy source.
14523	acts as a transcriptional repressor.
14524	
14525	
14526	this is a calmodulin-sensitive adenylyl cyclase. may be involved in regulatory processes in the central nervous system. it may play a role in memory acquisition and learning.
14527	
14528	
14529	
14530	
14531	
14532	
14533	involved in the morphogenesis of the adult appendages. gtpase-activating protein for p21-rac. promotes the exchange of rac-bound gdp by gtp.
14534	
14535	
14536	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
14537	
14538	
14539	involved in ph regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. major proton extruding system driven by the inward sodium ion chemical gradient. plays an important role in signal transduction.
14540	involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26s proteasome (by similarity).
14541	
14542	
14543	
14544	
14545	binds to gt and gc boxes promoters elements. probable transcriptional activator.
14546	
14547	
14548	
14549	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
14550	
14551	probable transcription regulator.
14552	
14553	
14554	
14555	
14556	
14557	
14558	transcriptional repressor.
14559	cytokine that binds to tnfrsf9. induces the proliferation of activated peripheral blood t-cells. may have a role in activation-induced cell death (aicd). may play a role in cognate interactions between t-cells and b-cells/macrophages.
14560	
14561	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
14562	
14563	subunit of the splicing factor sf3a required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex.
14564	
14565	
14566	
14567	
14568	
14569	
14570	
14571	
14572	
14573	
14574	
14575	
14576	
14577	
14578	
14579	
14580	
14581	
14582	
14583	tumor suppressor. it blocks the growth, invasion, and metastatic properties of mammary tumors. as it does not undergo the s (stressed) to r (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
14584	histone h3, along with histone h4, plays a central role in nucleosome formation.
14585	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
14586	
14587	
14588	
14589	
14590	
14591	
14592	
14593	
14594	
14595	
14596	
14597	
14598	motor for anterograde axonal transport of synaptic vesicle precursors (by similarity).
14599	
14600	
14601	
14602	
14603	
14604	
14605	receptor for atrial natriuretic peptide (anp), brain natriuretic peptide (bnp), and c-type natriuretic peptide (cnp). has guanylate cyclase activity on binding of ligand. the activation order seems to be cnp > bnp > anp.
14606	calcium-binding protein. may have a role in calcium homeostasis.
14607	
14608	
14609	
14610	
14611	
14612	calcium-binding protein required for t-cell receptor-, fas-, and glucocorticoid-induced cell death. may mediate ca(2+)- regulated signals along the death pathway (by similarity).
14613	
14614	
14615	tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. phosphorylates stat6, irs1, irs2 and pi3k.
14616	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
14617	causes the formation of thin, actin-rich surface projections called filopodia. functions cooperatively with cdc42 and rac to generate additional structures, increasing the diversity of actin-based morphology.
14618	muscle contraction.
14619	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
14620	integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence g-f-p-g-e-r in collagen. integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-v/beta-1 are receptors for fibronectin. alpha-4/beta-1 recognizes one or more domains within the alternatively spliced cs-1 and cs-5 regions of fibronectin. integrin alpha-5/beta-1 is a receptor for fibrinogen. integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. integrin alpha-4/beta-1 is a receptor for vcam1. it recognizes the sequence q-i-d-s in vcam1. integrin alpha-9/beta-1 is a receptor for vcam1, cytotactin and osteopontin. it recognizes the sequence a-e-i-d-g-i-e-l in cytotactin. integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and cspg4. alpha-3/beta-1 may mediate with lgals3 the stimulation by cspg4 of endothelial cells migration. integrin alpha-v/beta-1 is a receptor for vitronectin. beta-1 integrins recognize the sequence r-g-d in a wide array of ligands. isoform beta-1b interferes with isoform beta-1a resulting in a dominant negative effect on cell adhesion and migration (in vitro).
14621	
14622	
14623	
14624	
14625	
14626	
14627	
14628	
14629	may be an ion-channel regulator. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis. involved in adhesive protein-protein and protein-carbohydrate interactions.
14630	
14631	
14632	
14633	
14634	
14635	
14636	
14637	
14638	in addition to its role as a glycolytic enzyme, it seems that pgk-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
14639	
14640	
14641	
14642	
14643	
14644	adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. can bind to fibrinogen, fibronectin, laminin and type v collagen.
14645	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. utilizes a wide range of saturated fatty acids with a preference for c16-c18 unsaturated fatty acids (by similarity).
14646	
14647	integrin alpha-9/beta-1 is a receptor for vcam1, cytotactin and osteopontin. it recognizes the sequence a-e-i-d-g- i-e-l in cytotactin.
14648	
14649	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
14650	involved in the regulation of cell adhesion and in signal transduction through the wnt pathway.
14651	
14652	rapidly hydrolyzes choline released into the synapse.
14653	
14654	
14655	binds and activates tie2 receptor by inducing its tyrosine phosphorylation. implicated in endothelial developmental processes later and distinct from that of vegf. appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. mediates blood vessel maturation/stability. it may play an important role in the heart early development.
14656	cleaves the c-terminal propeptides of procollagen i, ii and iii. induces cartilage and bone formation.
14657	
14658	
14659	
14660	potassium channel activated by both membrane depolarization or increase in cytosolic ca(2+) that mediates export of k(+). it is also activated by the concentration of cytosolic mg(2+). its activation dampens the excitatory events that elevate the cytosolic ca(2+) concentration and/or depolarize the cell membrane. it therefore contributes to repolarization of the membrane potential. plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. in smooth muscles, its activation by high level of ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. in cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. kinetics of kcnma1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. highly sensitive to both iberiotoxin (ibtx) and charybdotoxin (ctx).
14661	
14662	
14663	
14664	
14665	
14666	plays an important role in the degradation of dermatan and keratan sulfates.
14667	
14668	involved in ubiquitination and subsequent proteasomal degradation of target proteins. plays a role in the polyubiquitination of cdt1 in response to radiation-induced dna damage.
14669	
14670	
14671	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
14672	
14673	
14674	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna (by similarity).
14675	
14676	
14677	promotes adhesion of endothelial cells through interaction of integrins and the rgd motif. could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling.
14678	
14679	
14680	
14681	
14682	
14683	
14684	
14685	
14686	part of the postsynaptic scaffold in neuronal cells.
14687	
14688	
14689	collagen type iii occurs in most soft connective tissues along with type i collagen.
14690	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes (by similarity).
14691	
14692	probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as notch receptors and app (beta-amyloid precursor protein). requires the other members of the gamma-secretase complex to have a protease activity. may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. may function in the cytoplasmic partitioning of proteins.
14693	
14694	binds to the gm-csf promoter. seems to act as a repressor. binds also to full length mrna and to short rna sequences containing the consensus site 5@#$%&-uccauca-3@#$%&. may have a role in translation repression (by similarity).
14695	
14696	
14697	directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mrna localization and the establishment of cell polarity.
14698	
14699	terminal component of the liver microsomal stearyl-coa desaturase system, that utilizes o(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-coa substrates including palmitoyl-coa and stearoyl-coa.
14700	
14701	involved in the maturation of asn-linked oligosaccharides. progressively trim alpha-1,2-linked mannose residues from man(9)glcnac(2) to produce man(5)glcnac(2).
14702	
14703	
14704	
14705	fabp are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-coa esters.
14706	
14707	involved in intracellular signal transduction mediated by cytokines and growth factors. probably acts via its association with ubiquitinated cargo proteins on the early endosome participates in their sorting for trafficking to the lysosome. upon il-2 and gm-csl stimulation, it plays a role in signaling leading to dna synthesis and c-myc induction. may also play a in t-cell development (by similarity).
14708	
14709	catalyzes the posttranslational addition of a tyrosine to the c-terminal end of detyrosinated alpha-tubulin.
14710	
14711	
14712	
14713	
14714	gtpase-activating protein for the adp ribosylation factor family (potential).
14715	
14716	inhibitor of protein-phosphatase 1.
14717	
14718	the long isoform may play a role in neural and glial cell adhesion in the developing embryo. the short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. vital for embryonic development. essential for septate junctions. septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. required for the blood-brain barrier formation.
14719	
14720	
14721	
14722	
14723	essential subunit of n-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an asn-x-ser/thr consensus motif in nascent polypeptide chains.
14724	
14725	
14726	
14727	
14728	may play a role in the control of gene expression.
14729	this enzyme condenses acetyl-coa with acetoacetyl-coa to form hmg-coa, which is the substrate for hmg-coa reductase.
14730	
14731	low concentration of a soluble form of interleukin-6 receptor acts as an agonist of il6 activity.
14732	
14733	
14734	
14735	
14736	
14737	
14738	
14739	
14740	
14741	
14742	
14743	
14744	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
14745	
14746	
14747	
14748	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
14749	
14750	part of the tip60 chromatin-remodelling complex which is involved in dna repair. upon induction of dna double-strand breaks, this complex acetylates phosphorylated h2av in nucleosomes and exchanges it with unmodified h2av.
14751	this protein promotes the gtp-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome.
14752	
14753	
14754	
14755	part of the ap-3 complex, an adaptor-related complex which is not clathrin-associated. the complex is associated with the golgi region as well as more peripheral structures. it facilitates the budding of vesicles from the golgi membrane and may be directly involved in trafficking to lysosomes.
14756	
14757	may function in membrane trafficking. exhibits calcium- dependent phospholipid binding properties (by similarity). seems to have a protein kinase activity.
14758	
14759	may play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
14760	
14761	
14762	involved in the maintenance of proximal germ cells by supporting their proliferation. probably regulates translation of specific mrnas by associating with the 3@#$%& untranslated regions (utrs) of mrna targets (by similarity).
14763	
14764	
14765	
14766	involved in t-cell antigen receptor mediated signaling.
14767	
14768	
14769	
14770	
14771	
14772	
14773	
14774	
14775	
14776	
14777	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
14778	
14779	
14780	
14781	
14782	
14783	
14784	
14785	
14786	
14787	
14788	
14789	
14790	
14791	motor required for the retrograde transport of golgi vesicles to the endoplasmic reticulum. has a microtubule plus end- directed motility.
14792	
14793	may act as a molecular switch during maturation of the 40s ribosomal subunit in the nucleolus (by similarity).
14794	sodium-phosphate symporter. active in early growth phase.
14795	
14796	
14797	
14798	
14799	
14800	
14801	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
14802	
14803	
14804	
14805	
14806	
14807	
14808	
14809	
14810	
14811	
14812	
14813	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
14814	
14815	
14816	
14817	
14818	
14819	
14820	
14821	
14822	
14823	recognizes and binds the palindromic sequence 5@#$%&- ttggcnnnnngccaa-3@#$%& present in viral and cellular promoters and in the origin of replication of adenovirus type 2. these proteins are individually capable of activating transcription and replication.
14824	
14825	
14826	
14827	
14828	
14829	
14830	
14831	during embryonic development, some isoforms are essential for proper neuronal differentiation and organization. required for cell polarity; maintenance of apicobasal polarity. plays a critical role at septate junctions in cellular growth control during larval development. the presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
14832	component of cohesin complex, a complex required for the cohesion of sister chromatids after dna replication. the cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. at anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. the cohesin complex may also play a role in spindle pole assembly during mitosis.
14833	required for protein transport from the er to the golgi complex.
14834	
14835	
14836	
14837	
14838	
14839	
14840	
14841	
14842	
14843	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. srp9 together with srp14 and the alu portion of the srp rna, constitutes the elongation arrest domain of srp. the complex of srp9 and srp14 is required for srp rna binding.
14844	
14845	
14846	
14847	
14848	
14849	
14850	
14851	
14852	
14853	
14854	
14855	
14856	
14857	
14858	
14859	
14860	
14861	
14862	represses hepatitis b virus (hbv) core promoter activity and transcription of hbv genes and production of hbv virions. binds to the consensus dna sequence: 5@#$%&-ga[gt]an[cg][ag]cc-3@#$%&. might protect cells from apoptosis. might be involved in pre-mrna splicing (by similarity).
14863	
14864	type i collagen is a member of group i collagen (fibrillar forming collagen).
14865	
14866	
14867	
14868	high specificity for fatty acids. highest affinity for c18 chain length. decreasing the chain length or introducing double bonds reduces the affinity. may be involved in keratinocyte differentiation.
14869	
14870	transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+) (by similarity).
14871	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
14872	catalyzes the s-methylation of thiopurine drugs such as 6-mercaptopurine.
14873	
14874	
14875	
14876	
14877	
14878	
14879	
14880	
14881	
14882	
14883	
14884	
14885	may be involved in transcriptional regulation.
14886	
14887	
14888	
14889	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
14890	
14891	
14892	mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient. it is a tetrodotoxin-sensitive na(+) channel isoform. plays a role in pain mechanisms, especially in the development of inflammatory pain (by similarity).
14893	
14894	
14895	
14896	
14897	
14898	
14899	
14900	
14901	
14902	
14903	
14904	the gamma subunit has a critical role in allowing the ige fc receptor to reach the cell surface.
14905	
14906	may be involved in transcriptional regulation.
14907	
14908	binds to dna at special at-rich sequences at nuclear matrix- or scaffold-associated regions. thought to recognize the sugar-phosphate structure of double-stranded dna.
14909	
14910	
14911	similar to that of somatotropin.
14912	
14913	protein kinase acting as a corepressor of several transcription factors, including smad1 and pou4f1/brn3a and probably nk homeodomain transcription factors. inhibits cell growth and promotes apoptosis. involved in transcriptional activation of tp53 and tp73. phosphorylation of tp53 may be mediated by a tp53-hipk2-axin1 complex. in response to tgfb, cooperates with daxx to activate jnk. phosphorylates the antiapoptotic factor ctbp1 and promotes its proteasomal degradation. in the wnt/beta-catenin signaling pathway acts as an intermediate kinase between tak1 and nlk to promote the proteasomal degradation of c-myb (by similarity).
14914	
14915	
14916	
14917	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
14918	
14919	
14920	
14921	in cooperation with other chaperones, hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. these chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. they bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
14922	putative odorant receptor.
14923	
14924	
14925	
14926	
14927	involved in regulating eumelanin and phaeomelanin levels.
14928	
14929	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
14930	
14931	
14932	type i collagen is a member of group i collagen (fibrillar forming collagen).
14933	
14934	
14935	
14936	
14937	
14938	may play a role in the formation and regulation of the tight junction (tj) paracellular permeability barrier. it is able to induce adhesion when expressed in cells lacking tight junctions.
14939	
14940	
14941	
14942	
14943	protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the golgi apparatus.
14944	
14945	
14946	
14947	
14948	
14949	
14950	
14951	aminopeptidase with broad substrate specificity to several peptides. involved in proteolytic events essential for cell growth and viability. may act as regulator of neuropeptide activity (by similarity).
14952	component of the circadian clock or downstream effector of clock function. exhibits a high amplitude circadian rhythm with maximal levels in early evening. in constant darkness or constant light, the amplitude of the rhythm decreases (by similarity).
14953	
14954	actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. may be down-regulated in neuroblastoma tumors.
14955	
14956	essential component of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. when overexpressed in cells induces the formation of cytoplasmic annulate lamellae (al) (by similarity).
14957	
14958	
14959	
14960	
14961	binds preferentially single-stranded dna and unwinds double stranded dna.
14962	
14963	transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. cbf binds to the core site, 5@#$%&- pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(i) collagen, lck, il-3 and gm-csf promoters (by similarity). inhibits myst4-dependent transcriptional activation.
14964	
14965	
14966	
14967	stratified squamous epithelial basement membrane protein that form anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ecm) proteins such as type iv collagen.
14968	
14969	
14970	
14971	required for protein transport from the er to the golgi complex.
14972	
14973	dual-specificity phosphatase. preferentially dephosphorylates proteins modified by proline-directed kinases.
14974	
14975	
14976	
14977	the glycine cleavage system catalyzes the degradation of glycine. the h protein shuttles the methylamine group of glycine from the p protein to the t protein (by similarity).
14978	transcriptional activator (by similarity). binds a gc box motif. could play a role in b-cell growth and development.
14979	activates the jun n-terminal pathway through activation of the map kinase kinase map2k7. acts synergistically with prdx3 to regulate the activation of nf-kappa-b in the cytosol. this activation is kinase-dependent and involves activating the ikk complex, the ikbkb-containing complex that phosphorylates inhibitors of nf-kappa-b.
14980	
14981	
14982	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. may play an important physiological function in brain. may play a regulatory role by modulating the cellular levels of fatty acyl- coa ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. has broad specificity, active towards fatty acyl-coas with chain-lengths of c8-c18.
14983	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. may play an important physiological function in brain. may play a regulatory role by modulating the cellular levels of fatty acyl- coa ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. has broad specificity, active towards fatty acyl-coas with chain-lengths of c8-c18.
14984	
14985	
14986	
14987	
14988	
14989	muscle contraction.
14990	
14991	
14992	
14993	
14994	
14995	
14996	
14997	
14998	
14999	plays a role in cytoplasmic trafficking of rna. binds to the cis-acting response element, a2re.
15000	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
15001	
15002	
15003	
15004	
15005	
15006	
15007	
15008	receptor for sema4d. plays a role in rhoa activation and subsequent changes of the actin cytoskeleton. plays a role in axon guidance, invasive growth and cell migration.
15009	transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
15010	
15011	
15012	involved in t-cell adhesion processes. it is involved in spontaneous rosette formation with erythrocytes.
15013	
15014	
15015	
15016	
15017	
15018	
15019	
15020	
15021	binds unprenylated rab proteins, presents it to the catalytic rab ggtase dimer, and remains bound to it after the geranylgeranyl transfer reaction. the component a is thought to be regenerated by transferring its prenylated rab back to the donor membrane. less effective than rep-1 in supporting prenylation of rab3 family.
15022	phosphorylates ptdins, ptdins4p and ptdins(4,5)p2 with a preference for ptdins(4,5)p2.
15023	
15024	
15025	
15026	
15027	
15028	responsible for the biosynthesis of pyroglutamyl peptides. has a bias against acidic and tryptophan residues adjacent to the n-terminal glutaminyl residue and a lack of importance of chain length after the second residue.
15029	
15030	
15031	
15032	may function as a testis specific transcription factor. binds dna in conjunction with gtf2a2 and tbp (the tata-binding protein) and together with gtf2a2, allows mrna transcription.
15033	
15034	
15035	
15036	
15037	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
15038	
15039	
15040	
15041	
15042	
15043	may play a role in binding dynein to membranous organelles or chromosomes. may associate with the heavy chains in the dynein head where they might regulate enzyme activity (by similarity).
15044	
15045	
15046	inactivation of prostaglandins.
15047	
15048	
15049	
15050	
15051	attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to na-k atpase, to the lymphocyte membrane protein gp85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. in skeletal muscle, isoform mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
15052	
15053	
15054	isoform 2 up-regulates the production of ghbp and acts as a negative inhibitor of gh signaling.
15055	promotes the exchange of ras-bound gdp by gtp.
15056	not known.
15057	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
15058	involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
15059	
15060	prefers o-glycans to n-glycans or glycolipids as acceptor substrates. the minimal acceptor substrate is the neuac- alpha-2,3(6)-gal sequence at the nonreducing end of their carbohydrate groups (by similarity).
15061	
15062	
15063	involved in pre-mrna splicing. this protein is associated with snrnp u2. it binds stem loop iv of u2 snrna only in presence of the u2a@#$%& protein.
15064	
15065	part of a complex implicated in the control of actin polymerization in cells (by similarity).
15066	
15067	component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnrnp). hnrnp play an important role in processing of precursor mrna in the nucleus.
15068	
15069	part of pre- and post-splicing multiprotein mrnp complexes. enhances the formation of the atp-dependent a complex of the spliceosome. involved in both constitutive splicing and, in association with srp54 and sfrs10, in distinctive modulation of alternative splicing in a substrate-dependent manner. participates in mrna 3@#$%&end cleavage. involved in rent2-dependent nonsense- mediated decay (nmd) of mrnas containing premature stop codons. also mediates increase of mrna abundance and translational efficiency. binds spliced mrna 20-25 nt upstream of exon-exon junctions.
15070	inhibitor of protein-phosphatase 1.
15071	
15072	
15073	
15074	may play a role in cell-cycle regulation during the transition from gamete to embryo (by similarity).
15075	
15076	
15077	
15078	
15079	
15080	
15081	
15082	
15083	calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis (by similarity).
15084	endonuclease that cleaves the 5@#$%& overhanging flap structure that is generated by displacement synthesis when dna polymerase encounters the 5@#$%& end of a downstream okazaki fragment. also possesses 5@#$%& to 3@#$%& exonuclease activity on niked or gapped double-stranded dna, and exhibits rnase h activity.
15085	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
15086	
15087	
15088	
15089	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. isoform serca2a is involved in the regulation of the contraction/relaxation cycle.
15090	
15091	
15092	
15093	putative transcription factor. involved in hair formation and spermatogenesis. may function in the differentiation and/or maintenance of the urogenital system (by similarity).
15094	protein kinase that act on both serine and threonine residues.
15095	
15096	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
15097	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
15098	
15099	recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (by similarity).
15100	stimulates a migratory response in cd4+ lymphocytes, monocytes, and eosinophils. also induces t-lymphocyte expression of interleukin 2 receptor. ligand for cd4.
15101	
15102	
15103	
15104	
15105	
15106	
15107	
15108	
15109	
15110	
15111	
15112	
15113	
15114	exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper b into subunit i (by similarity).
15115	
15116	binds to the basic helix-loop-helix protein tal-1. this interaction seems to be critical for the regulation of red blood cell development.
15117	may function as a housekeeping dna-binding protein that regulates the expression of specific genes. has been shown to bind to the promoters of adenovirus major late protein and cyclin d1 and activate transcription. also has potent growth arrest activity, probably through inhibition of cell cycle progression. required for early embryonic development during gastrulation.
15118	
15119	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
15120	
15121	
15122	
15123	
15124	
15125	
15126	
15127	protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. this protein is also a carboxypeptidase and can deamidate tachykinins.
15128	protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. this protein is also a carboxypeptidase and can deamidate tachykinins.
15129	involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors.
15130	
15131	
15132	inhibits the wnt/wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation by competing with tcf/lef transcription factors. has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/pkd2 and possibly of other intracellular proteins.
15133	
15134	
15135	
15136	
15137	
15138	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
15139	
15140	
15141	
15142	
15143	
15144	histone demethylase that specifically demethylates lys-4 of histone h3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. acts by oxidizing the substrate by fad to generate the corresponding imine that is subsequently hydrolyzed. demethylates both mono- and tri-methylted lys-4 of histone h3. may play a role in the repression of neuronal genes. alone, it is unable to demethylate h3 lys-4 on nucleosomes and requires the presence of rcor1/corest to achieve such activity. may also demethylate lys-9 of histone h3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.
15145	
15146	
15147	
15148	
15149	the function of subunit 3 is not clear.
15150	may bind rna.
15151	transcription factor.
15152	
15153	catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in rab proteins with an -xxcc, -xcxc and -ccxx c-terminal, such as rab1a, rab3a and rab5a respectively.
15154	
15155	involved in oxygen transport from the lung to the various peripheral tissues.
15156	
15157	
15158	plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity.
15159	
15160	
15161	
15162	
15163	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. binds to bmp-7, bmp-2 and, less efficiently, bmp-4. binding is weak but enhanced by the presence of type i receptors for bmps.
15164	
15165	
15166	cysteine protease. may have an important role in corneal physiology.
15167	function in general translation initiation by promoting the binding of the formylmethionine-trna to ribosomes. seems to function along with eif-2.
15168	
15169	
15170	nucleolin is the major nucleolar protein of growing eukaryotic cells. it is found associated with intranucleolar chromatin and preribosomal particles. it induces chromatin decondensation by binding to histone h1. it is thought to play a role in pre-rrna transcription and ribosome assembly.
15171	
15172	
15173	
15174	
15175	
15176	
15177	
15178	
15179	
15180	
15181	
15182	
15183	
15184	
15185	
15186	
15187	essental for release from glucose repression. it interacts and has functional relationship to the regulatory protein snf4. interacts also with sip1, sip2 and gal83. could phosphorylates cat8.
15188	
15189	
15190	
15191	
15192	integrin alpha-v/beta-8 is a receptor for fibronectin.
15193	
15194	
15195	
15196	
15197	
15198	
15199	
15200	
15201	
15202	
15203	
15204	
15205	
15206	
15207	
15208	
15209	
15210	microtubule-associated force-producing protein that participates mitochondrial fission. fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. functions antagonistically with fzo1.
15211	
15212	
15213	
15214	this protein promotes the gtp-dependent binding of aminoacyl-trna to the a-site of ribosomes during protein biosynthesis.
15215	
15216	
15217	
15218	
15219	high specificity for fatty acids. highest affinity for c18 chain length. decreasing the chain length or introducing double bonds reduces the affinity. may be involved in keratinocyte differentiation.
15220	
15221	
15222	
15223	
15224	downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small gtpases to the actin cytoskeleton.
15225	
15226	
15227	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
15228	
15229	the l3 protein is a component of the large subunit of cytoplasmic ribosomes.
15230	the l3 protein is a component of the large subunit of cytoplasmic ribosomes.
15231	
15232	
15233	part of pre- and post-splicing multiprotein mrnp complexes. enhances the formation of the atp-dependent a complex of the spliceosome. involved in both constitutive splicing and, in association with srp54 and sfrs10, in distinctive modulation of alternative splicing in a substrate-dependent manner. participates in mrna 3@#$%&end cleavage. involved in rent2-dependent nonsense- mediated decay (nmd) of mrnas containing premature stop codons. also mediates increase of mrna abundance and translational efficiency. binds spliced mrna 20-25 nt upstream of exon-exon junctions.
15234	
15235	
15236	
15237	may play a role in nucleosome assembly by neutralizing basic proteins such as a and b core hnrnps (by similarity).
15238	promotes the exchange of cdc42-bound gdp by gtp. controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. cdc24 may be involved in the initial selection and organization of the budding site.
15239	
15240	
15241	
15242	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
15243	controls sodium and chloride ion transport by inhibiting the activity of wnk4, potentially by either phosphorylating the kinase or via an interaction between wnk4 and the autoinhibitory domain of wnk1. wnk4 regulates the activity of the thiazide- sensitive na-cl cotransporter, slc12a3, by phosphorylation. wnk1 may also play a role in actin cytoskeletal reorganization.
15244	
15245	
15246	functions as a master transcriptional regulator of the adaptive response to hypoxia. under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. binds to core dna sequence 5@#$%&-[ag]cgtg-3@#$%& within the hypoxia response element (hre) of target gene promoters. activation requires recruitment of transcriptional coactivators such as crebpb and ep300. activity is enhanced by interaction with both, ncoa1 or ncoa2. interaction with redox regulatory protein apex seems to activate ctad and potentiates activation by ncoa1 and crebbp.
15247	may have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
15248	
15249	
15250	
15251	
15252	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
15253	
15254	
15255	
15256	
15257	
15258	receptor for slit1 and slit2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. in axon growth cones, the silencing of the attractive effect of ntn1 by slit2 may require the formation of a robo1-dcc complex. may be required for lung development.
15259	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
15260	implicated in the control of cell proliferation and cellular aging. may also act as a chaperone.
15261	
15262	acts as a coactivator in the regulation of translation initiation of poly(a)-containing mrnas. its stimulatory activity on translation is mediated via its action on pabpc1. competes with paip2 for binding to pabpc1. its association with eif4a and pabpc1 may potentiate contacts between mrna termini. may also be involved in translationally coupled mrna turnover. implicated with other rna-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding-region determinant of instability (mcrd) domain.
15263	
15264	
15265	participates in the folding of proteins containing disulfide bonds (by similarity).
15266	
15267	
15268	
15269	
15270	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to the dna sequence 5@#$%&-aa[at]ttttattac-3@#$%&.
15271	
15272	
15273	
15274	
15275	
15276	
15277	
15278	
15279	
15280	
15281	
15282	
15283	mediates endoplasmic reticulum to golgi transport (by similarity).
15284	mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. the receptor recognizes terminal galactose and n-acetylgalactosamine units. after ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. the receptor then returns to the cell membrane surface.
15285	
15286	transcription factor that appears to be required for the t-cell-receptor-mediated trans activation of hiv-2 gene expression. binds specifically to two purine-rich motifs in the hiv-2 enhancer. transcriptionally activates the lyn and mouse blk promoters.
15287	
15288	
15289	
15290	
15291	
15292	
15293	receptor for glucocorticoids (gc). has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (gre) and as a modulator of other transcription factors. affects inflammatory responses, cellular proliferation and differentiation in target tissues. could act as a coactivator for stat5-dependent transcription upon growth hormone (gh) stimulation and could reveal an essential role of hepatic gr in the control of body growth.
15294	
15295	essential for the import of protein precursors into the mitochondria (by similarity).
15296	functions as histone acetyltransferase and regulates transcription via chromatin remodeling. acetylates all four core histones in nucleosomes. histone acetylation gives an epigenetic tag for transcriptional activation. binds to and may be involved in the transforming capacity of the adenovirus e1a protein. mediates camp-gene regulation by binding specifically to phosphorylated creb protein.
15297	
15298	may be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (by similarity).
15299	
15300	
15301	multifunctional protein that control proliferation, differentiation, and other functions in many cell types. many cells synthesize tgfb1 and essentially all of them have specific receptors for this protein. it regulates the actions of many other growth factors and determines a positive or negative direction of their effects. it plays an important role in bone remodelling. it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
15302	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
15303	
15304	
15305	
15306	
15307	
15308	
15309	
15310	plays a major role in tight junction-specific obliteration of the intercellular space (by similarity).
15311	
15312	
15313	
15314	
15315	
15316	exchange factor for gtp-binding proteins rhoa, rhog and, to a lesser extent, rac1. binds physically to the nucleotide-free states of those gtpases.
15317	catalyzes the posttranslational addition of a tyrosine to the c-terminal end of detyrosinated alpha-tubulin.
15318	
15319	drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. may also be linked to the malignant phenotype.
15320	
15321	
15322	
15323	
15324	
15325	
15326	
15327	
15328	catalyzes the nadph-dependent reduction of a variety of aldehydes to their corresponding alcohols (by similarity).
15329	catalyzes the nadph-dependent reduction of a variety of aldehydes to their corresponding alcohols (by similarity).
15330	
15331	
15332	
15333	
15334	
15335	
15336	
15337	involved in vesicular protein trafficking.
15338	may be involved in the regulation of dopamine release and transport. soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). induces fibrillization of microtubule- associated protein tau. reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation.
15339	
15340	binds preferentially single-stranded dna and unwinds double stranded dna.
15341	differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
15342	modulates the activation of caspases during apoptosis. is a substrate for orgyia pseudotsugata multicapsid polyhedrosis virus (opmnpv) iap-mediated ubiquitination.
15343	arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
15344	
15345	
15346	
15347	
15348	
15349	seems to act exclusively upon threonine residues (by similarity).
15350	
15351	
15352	
15353	
15354	
15355	
15356	associates with the cytoplasmic domain of a variety of cadherins. the association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. may play a crucial role in cell differentiation.
15357	
15358	vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (by similarity).
15359	
15360	
15361	
15362	
15363	
15364	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator.
15365	
15366	
15367	
15368	
15369	
15370	
15371	
15372	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
15373	
15374	
15375	
15376	
15377	
15378	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain (by similarity).
15379	
15380	
15381	
15382	
15383	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&. activates transcription of pf4 in complex with meis1.
15384	
15385	
15386	transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
15387	involved in g1 arrest. may mediate tgf beta-induced g1 arrest. binds to and inhibits complexes formed by cyclin e-cdk2, cyclin a-cdk2, and cyclin d1-cdk4. interaction with nucleoporin nup50 is required for nuclear import and for degradation of phosphorylated p27kip1 after nuclear import (by similarity).
15388	facilitative glucose transporter. probably a neuronal glucose transporter.
15389	may be involved in cytokinesis, motility, and signal transduction (by similarity).
15390	
15391	
15392	
15393	
15394	gtp-binding protein with gtpase activity. elicits the formation of f-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (by similarity).
15395	seems to specifically activate progelatinase a. may thus trigger invasion by tumor cells by activating progelatinase a on the tumor cell surface.
15396	
15397	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
15398	
15399	
15400	6-o-sulfation enzyme which catalyzes the transfer of sulfate from 3@#$%&-phosphoadenosine 5@#$%&-phosphosulfate (paps) to position 6 of the n-sulfoglucosamine residue (glcns) of heparan sulfate.
15401	
15402	
15403	
15404	molecular chaperone. has atpase activity (by similarity).
15405	
15406	
15407	histone h3, along with histone h4, plays a central role in nucleosome formation.
15408	may play a role in promoting maturation and morphological differentiation of cerebellar neurons.
15409	
15410	
15411	
15412	
15413	
15414	associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. it may function in the assembly and/or transport of ribosome.
15415	
15416	
15417	the gpib-v-ix complex functions as the von willebrand factor receptor and mediates von willebrand factor-dependent platelet adhesion to blood vessels. the adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis (by similarity).
15418	
15419	
15420	may play a role in a erbb3-regulated signal transduction pathway. seems be involved in growth regulation. acts a corepressor of the androgen receptor (ar) and is regulated by the erbb3 ligand neuregulin-1/heregulin (hrg). inhibits transcription of some e2f1-regulated promoters, probably by recruiting histone acetylase (hat) activity. binds rna. associates with 28s, 18s and 5.8s mature rrnas, several rrna precursors and probably u3 small nucleolar rna. may be involved in regulation of intermediate and late steps of rrna processing. may be involved in ribosome assembly (by similarity). mediates cap-independent translation of specific viral iress (internal ribosomal entry site). together with ptbp1 is required for the translation initiation on the foot- and-mouth disease virus (fmdv) ires.
15421	
15422	
15423	
15424	probably involved in membrane protein trafficking (by similarity).
15425	
15426	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
15427	participates in the bidirectional intercellular signaling between the posterior follicle cells and oocyte to establish spatial coordinates that induces axis formation. complex with tsu is essential for cytoplasmic localization of oskar in the posterior pole of oocytes. required for the polarization of the oocyte microtubule cytoskeleton.
15428	
15429	
15430	
15431	may play a role in spermatogenesis.
15432	may play a role in spermatogenesis.
15433	
15434	
15435	
15436	
15437	
15438	
15439	
15440	
15441	essential component of the nelf complex, a complex that negatively regulates the elongation of transcription by rna polymerase ii. the nelf complex, which acts via an association with the dsif complex and causes transcriptional pausing, is counteracted by the p-tefb kinase complex. probably required to interact with the rna polymerase ii complex.
15442	associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. it may function in the assembly and/or transport of ribosome.
15443	
15444	
15445	
15446	
15447	
15448	
15449	
15450	
15451	an integral component of the pericentriolar material (pcm).
15452	
15453	
15454	component of pre-mrna cleavage complex ii.
15455	may be involved in the binding and intracellular trafficking of cobalamin (vitamin b12).
15456	probable glucose transporter.
15457	
15458	
15459	
15460	
15461	
15462	
15463	
15464	
15465	
15466	
15467	
15468	
15469	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
15470	
15471	
15472	
15473	
15474	
15475	
15476	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
15477	
15478	
15479	
15480	high affinity receptor for semaphorins 3c, 3f, vegf-165 and vegf-145 isoforms of vegf, and the plgf-2 isoform of pgf.
15481	
15482	
15483	does not possess sterol isomerase activity and does not bind sigma ligands (by similarity).
15484	
15485	
15486	
15487	
15488	
15489	
15490	
15491	this receptor binds polymeric iga and igm at the basolateral surface of epithelial cells. the complex is then transported across the cell to be secreted at the apical surface. during this process a cleavage occurs that separate the extracellular (known as the secretory component) from the transmembrane segment.
15492	
15493	
15494	
15495	
15496	
15497	appears to have dual functions such as cytoplasmic retention of attached nf-kappa-b proteins and generation of p50 by a cotranslational processing. the proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of nfkb1/p105 also appears to occur posttranslationally. p50 binds to the kappa-b consensus sequence 5@#$%&-ggrnnyycc-3@#$%&, located in the enhancer region of genes involved in immune response and acute phase reactions. plays a role in the regulation of apoptosis.
15498	
15499	
15500	
15501	
15502	
15503	
15504	
15505	
15506	
15507	
15508	
15509	
15510	
15511	
15512	
15513	
15514	
15515	
15516	multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
15517	endonuclease that cleaves the 5@#$%& overhanging flap structure that is generated by displacement synthesis when dna polymerase encounters the 5@#$%& end of a downstream okazaki fragment. also possesses 5@#$%& to 3@#$%& exonuclease activity on niked or gapped double-stranded dna, and exhibits rnase h activity.
15518	
15519	
15520	necessary for protein translocation in the endoplasmic reticulum.
15521	
15522	essential component of the nelf complex, a complex that negatively regulates the elongation of transcription by rna polymerase ii. the nelf complex, which acts via an association with the dsif complex and causes transcriptional pausing, is counteracted by the p-tefb kinase complex.
15523	
15524	
15525	
15526	probably involved in nervous system development and function.
15527	
15528	
15529	
15530	
15531	probably involved in egf and insulin receptor signaling.
15532	
15533	induces cartilage and bone formation. may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. plays a role in calcium regulation and bone homeostasis (by similarity).
15534	
15535	rab4/rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. required for endosome fusion either homotypically or with clathrin coated vesicles. plays a role in the lysosomal trafficking of cathepsin d from the golgi to lysosomes. also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (ptdinsp3).
15536	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
15537	
15538	
15539	
15540	
15541	
15542	prohibitin inhibits dna synthesis. it has a role in regulating proliferation. as yet it is unclear if the protein or the mrna exhibits this effect. may play a role in regulating mitochondrial respiration activity and in aging.
15543	receptor for atrial natriuretic peptide (anp), brain natriuretic peptide (bnp), and c-type natriuretic peptide (cnp). has guanylate cyclase activity on binding of ligand. the activation order seems to be cnp > bnp > anp.
15544	
15545	
15546	
15547	involved in cytokinesis (potential).
15548	fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, dna, and actin. fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. interaction with tnr mediates inhibition of cell adhesion and neurite outgrowth (by similarity).
15549	
15550	
15551	
15552	
15553	
15554	
15555	
15556	
15557	
15558	can act as repulsive axon guidance cues. may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (by similarity).
15559	recognizes and binds the palindromic sequence 5@#$%&- ttggcnnnnngccaa-3@#$%& present in viral and cellular promoters and in the origin of replication of adenovirus type 2. these proteins are individually capable of activating transcription and replication.
15560	
15561	
15562	
15563	
15564	could be involved in bone formation.
15565	
15566	
15567	
15568	involved in the presentation of foreign antigens to the immune system.
15569	
15570	
15571	
15572	
15573	
15574	involved in regulation of actin cytoskeleton organization and endocytosis.
15575	may be involved in transcriptional regulation.
15576	
15577	
15578	
15579	
15580	
15581	
15582	
15583	
15584	
15585	
15586	
15587	
15588	
15589	
15590	
15591	
15592	
15593	the cd3 complex mediates signal transduction.
15594	
15595	may play a role in the processes of lymphocyte homing to secondary lymphoid organs.
15596	
15597	
15598	could be involved in signal transduction.
15599	
15600	heparin binding mitogenic protein. has neurite extension activity.
15601	
15602	
15603	
15604	
15605	
15606	polycomb group (pcg) protein. pcg proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. pcg proteins are not required to initiate repression, but to maintain it during later stages of development. they probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. component of the prc2 complex, which methylates lys-9 and lys-27 residues of histone h3.
15607	
15608	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
15609	
15610	
15611	
15612	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
15613	
15614	collagen type iii occurs in most soft connective tissues along with type i collagen.
15615	may constitute a glutathionine peroxidase-like protective system against oxidative stresses (by similarity).
15616	
15617	
15618	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
15619	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
15620	this protein promotes the gtp-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome.
15621	transcriptional regulator that probably plays an important role in lymphomagenesis.
15622	
15623	
15624	
15625	
15626	
15627	may play a role in lipid exchange and transport throughout the body. may participate in reverse cholesterol transport from peripheral cells to the liver.
15628	
15629	
15630	part of the postsynaptic scaffold in neuronal cells.
15631	
15632	
15633	
15634	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. may be involved in the remodeling of the actin cytoskeleton. binds actin with high affinity both in the absence and presence of atp and its mechanochemical activity is inhibited by calcium ions. also acts as a gtpase activating protein on rho.
15635	
15636	
15637	
15638	
15639	
15640	
15641	
15642	
15643	muscle contraction.
15644	
15645	
15646	secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides.
15647	
15648	
15649	
15650	serine protease that shows proteolytic activity against a nonspecific substrate beta-casein. promotes or induces cell death either by direct binding to and inhibition of birc proteins (also called inhibitor of apoptosis proteins, iaps), leading to an increase in caspase activity, or by a birc inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. isoform 2 seems to be proteolytically inactive.
15651	muscle contraction.
15652	
15653	
15654	together with cas it may play a role in the control of epithelial cell polarity. seems to help to recruit protein tyrosine kinase 2 beta (ptk2b) to cell matrix adhesions, thereby initiating phosphorylation of ptk2b and ptk2b-dependent signaling (by similarity).
15655	may serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. weakly activates the map kinase pathway.
15656	
15657	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation via its interaction with the myocyte enhancer factors such as mef2a, mef2c and mef2d.
15658	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
15659	integrin alpha-v/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von willebrand factor. integrin alpha-iib/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. integrins alpha-iib/beta-3 and alpha-v/beta-3 recognize the sequence r-g-d in a wide array of ligands. integrin alpha-iib/beta-3 recognizes the sequence h-h-l-g-g-g-a-k-q-a-g-d-v in fibrinogen gamma chain. following activation integrin alpha- iib/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. this step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
15660	possible adhesion molecule with a role in early hematopoiesis by mediating attachment to stromal cells. influences the survival and/or proliferation of b-cell precursors. binding to cells requires mn(2+) (by similarity).
15661	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
15662	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
15663	
15664	required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
15665	
15666	
15667	
15668	
15669	
15670	
15671	
15672	
15673	
15674	probably involved in lipid transport.
15675	
15676	
15677	
15678	
15679	
15680	
15681	
15682	
15683	rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. it may also have a role in the development of malignancy and the growth progression of some tumors.
15684	
15685	
15686	
15687	
15688	aminopeptidases catalyze the hydrolysis of amino acid residues from the n-terminus of peptide or protein substrates. able to cleave angiotensin iii to generate angiotensin iv, a bioactive peptide of the renin-angiotensin pathway. not able to cleave angiotensin i and angiotensin ii. may play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.
15689	adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. mediates activation of nf-kappa-b and jnk and is involved in apoptosis. the traf1/traf2 complex recruits the apoptotic suppressors birc2 and birc3 to tnfrsf1b/tnfr2.
15690	
15691	
15692	
15693	
15694	
15695	synthesizes selenophosphate from selenide and atp.
15696	membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. binds to calmodulin.
15697	
15698	
15699	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
15700	
15701	
15702	
15703	
15704	receptor for basic fibroblast growth factor. a shorter form of the receptor could be a receptor for fgf1 (afgf).
15705	involved in the replication of mitochondrial dna.
15706	
15707	
15708	
15709	
15710	
15711	
15712	
15713	splice factor that is required for the first atp- dependent step in spliceosome assembly and for the interaction of u2 snrnp with the branchpoint. has weak rna-dependent atpase activity. required for mrna export.
15714	
15715	probable trna acetyltransferase required for the formation of the modified nucleoside n(4)-acetylcytidine in serine and leucine trnas. binds rna.
15716	involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
15717	binds with high affinity to rna molecules that contain au-rich elements (ares) found within the 3@#$%& untranslated regions of many protooncogenes and cytokine mrnas. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain (by similarity).
15718	
15719	
15720	
15721	
15722	
15723	
15724	golgi auto-antigen; probably involved in maintaining cis-golgi structure.
15725	may be involved in transcriptional regulation.
15726	histone h3, along with histone h4, plays a central role in nucleosome formation.
15727	
15728	
15729	
15730	
15731	
15732	
15733	
15734	mediates the association of the molecular chaperones hsc70 and hsp90 (hspca and hspcb).
15735	plays a role in the insulin signaling pathway.
15736	
15737	
15738	
15739	
15740	
15741	appears to mediate interactions between cells and the extracellular matrix. substrate-adhesion molecule that appears to inhibit cell migration. may play a role in supporting the growth of epithelial tumors.
15742	
15743	
15744	
15745	
15746	muscle contraction.
15747	transcriptional activator that binds with high affinity to the t-cell enhancer motif 5@#$%&-aacaaag-3@#$%& motif.
15748	
15749	important modulator in the hla class ii restricted antigen presentation pathway by interaction with the hla-dm molecule.
15750	
15751	the muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of g proteins. primary transducing effect is adenylate cyclase inhibition.
15752	
15753	
15754	type i collagen is a member of group i collagen (fibrillar forming collagen).
15755	
15756	
15757	
15758	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules (by similarity).
15759	involved in the presentation of foreign antigens to the immune system.
15760	
15761	
15762	may be required for neuronal cell differentiation.
15763	
15764	
15765	the enzyme cleaves lys-arg and arg-ser bonds. it activates, in a reciprocal reaction, factor xii after its binding to a negatively charged surface. it also releases bradykinin from hmw kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
15766	
15767	
15768	
15769	
15770	
15771	
15772	interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. could also bind muscle proteins such as actin to membrane complexes in muscle. may be involved not only in the crosslinking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.
15773	
15774	
15775	
15776	macrophage-specific membrane transport. important in metal transport, in particular iron.
15777	component of the anaphase promoting complex/cyclosome (apc/c), a cell cycle-regulated e3 ubiquitin-protein ligase complex that controls progression through mitosis and the g1 phase of the cell cycle. the apc/c is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating e2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26s proteasome. in early mitosis, the apc/c is activated by cdc20 and targets securin pds1, the b-type cyclin clb5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. in late mitosis and in g1, degradation of clb5 allows activation of the apc/c by cdh1, which is needed to destroy cdc20 and the b-type cyclin clb2 to allow exit from mitosis and creating the low cdk state necessary for cytokinesis and for reforming prereplicative complexes in g1 prior to another round of replication.
15778	
15779	regulates eif4e activity by preventing its assembly into the eif4f complex. mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the map kinase pathway.
15780	
15781	
15782	transcriptional factor which uses the canonical single or multiple carg boxes dna sequence. acts as a cofactor of serum response factor (srf) and has the potential to modulate srf-target genes. suppresses tnf-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. it may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (by similarity).
15783	
15784	
15785	
15786	
15787	
15788	
15789	
15790	
15791	
15792	the physiological function of prp is not known.
15793	
15794	
15795	
15796	
15797	
15798	
15799	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. may govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
15800	this is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters. may be considered as a novel component of the nf-kappa-b signaling axis responsible for the survival and activation of b-cells after bcr cross-linking (by similarity).
15801	
15802	the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-coa and co(2). it contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (e1), lipoamide acyltransferase (e2) and lipoamide dehydrogenase (e3).
15803	critical component of the membrane-bound oxidase of phagocytes that generates superoxide. it is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic nadph across the plasma membrane to molecular oxygen on the exterior. also functions as a voltage-gated proton channel that mediates the h(+) currents of resting phagocytes. it participates in the regulation of cellular ph and is blocked by zinc.
15804	
15805	seems to act exclusively upon threonine residues (by similarity).
15806	
15807	
15808	interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. could also bind muscle proteins such as actin to membrane complexes in muscle. may be involved not only in the crosslinking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.
15809	
15810	
15811	
15812	
15813	
15814	
15815	
15816	
15817	
15818	may act as a gtpase activating protein for rab family protein(s) (potential).
15819	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
15820	
15821	
15822	
15823	
15824	
15825	
15826	inactivates histamine by n-methylation. plays an important role in degrading histamine and in regulating the airway response to histamine.
15827	
15828	
15829	binding of freac-3 and freac-4 to their cognate sites results in bending of the dna at an angle of 80-90 degrees.
15830	
15831	
15832	
15833	may play a role in regulation of differentiation. in vitro, binds rna, preferentially to both poly(g) and poly(u). overexpressed, blocks differentiation of k562 leukemia cells following treatment with phorbol esters or sodium butyrate without affecting proliferation.
15834	accessory protein for the calcitonin gene-related peptide (cgrp) receptor. it modulates cgrp responsiveness in a variety of tissues.
15835	
15836	
15837	
15838	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
15839	highly selective for arachidonate-containing species of diacylglycerol (dag). may terminate signals transmitted through arachidonoyl-dag or may contribute to the synthesis of phospholipids with defined fatty acid composition.
15840	
15841	
15842	
15843	
15844	
15845	
15846	possible cell adhesion receptor. it possesses an intrinsic protein tyrosine phosphatase activity (ptpase). it controls motor axon guidance.
15847	
15848	
15849	
15850	
15851	cbf binds to the core site, 5@#$%&-pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, lck, il-3 and gm-csf promoters. the alpha subunit binds dna and appears to have a role in the development of normal hematopoiesis. isoform aml-1l interferes with the transactivation activity of runx1. acts synergistically with elf4 to transactivate the il-3 promoter and with elf2 to transactivate the mouse blk promoter. inhibits myst4- dependent transcriptional activation.
15852	
15853	
15854	major airway glycoprotein.
15855	
15856	
15857	
15858	
15859	
15860	
15861	mrs4 suppresses a mitochondrial splice defect in the first intron of the cob gene. it may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). not essential.
15862	
15863	
15864	
15865	
15866	
15867	binds to, and destabilizes, ornithine decarboxylase which is then degraded. also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter.
15868	
15869	
15870	
15871	
15872	binds and is activated by neuregulins and ntak.
15873	
15874	sodium-ion dependent, high affinity carnitine transporter. involved in the active cellular uptake of carnitine. transports one sodium ion with one molecule of carnitine. also transports organic cations such as tetraethylammonium (tea) without the involvement of sodium. also relative uptake activity ratio of carnitine to tea is 11.3.
15875	regulator of protein export for nes-containing proteins. also plays a role in mrna nuclear export.
15876	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
15877	
15878	
15879	receptor for hyaluronic acid (ha). mediates cell-cell and cell-matrix interactions through its affinity for ha, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix matalloproteinases (mmps). adhesion with ha plays an important role in cell migration, tumor growth and progression. also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. altered expression or dysfunction causes numerous pathogenic phenotypes. great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
15880	
15881	
15882	
15883	acts as a multispecific organic anion pump which can transport nucleotide analogs.
15884	
15885	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
15886	
15887	
15888	
15889	
15890	appears to play a role in the switch from cap-dependent to ires-mediated translation during mitosis, apoptosis and viral infection. cleaved by some caspases and viral proteases.
15891	
15892	
15893	the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-coa and co(2). it contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (e1), lipoamide acyltransferase (e2) and lipoamide dehydrogenase (e3).
15894	
15895	
15896	
15897	
15898	probably functions as an alternative splicing regulator. may regulate the mrna splicing of genes such as clk1. may act by regulating members of the clk kinase family (by similarity).
15899	sperm surface antigen involved in some step of early cleavage of the fertilized oocyte.
15900	may be involved in transcriptional regulation.
15901	
15902	
15903	
15904	
15905	
15906	
15907	
15908	
15909	
15910	
15911	
15912	
15913	
15914	
15915	
15916	plays a role in the import of cytosolically synthesized preproteins into mitochondria. binds the mature portion of precursor proteins. interacts with cellular components, and possesses weak atpase activity. may be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.
15917	
15918	required for protein transport from the er to the golgi complex.
15919	component of the origin recognition complex (orc) that binds origins of replication. it has a role in both chromosomal replication and mating type transcriptional silencing. binds to the ars consensus sequence (acs) of origins of replication in an atp-dependent manner.
15920	
15921	
15922	
15923	
15924	
15925	
15926	inhibitory effect on stress fiber organization. may down-regulate rho-like gtpase in hematopoietic cells.
15927	could have a part in mechanisms of transcriptional regulation similar to that played by yeast hir1 and hir2 together.
15928	
15929	
15930	binds the camp response element (cre) (consensus: 5@#$%&- gtgacgt[ag][ag]-3@#$%&), a sequence present in many viral and cellular promoters.
15931	
15932	
15933	
15934	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
15935	possibly acts as a transcriptional regulatory factor.
15936	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. may be involved in the remodeling of the actin cytoskeleton. binds actin with high affinity both in the absence and presence of atp and its mechanochemical activity is inhibited by calcium ions. also acts as a gtpase activating protein on rho.
15937	
15938	
15939	
15940	
15941	
15942	
15943	possible chloride ion channel.
15944	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
15945	
15946	
15947	
15948	
15949	collagen type iv is specific for basement membranes.
15950	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. has angiogenic inhibitor activity (by similarity). active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture (by similarity).
15951	protein transport. probably involved in vesicular traffic (by similarity).
15952	
15953	
15954	
15955	sperm surface antigen involved in some step of early cleavage of the fertilized oocyte.
15956	
15957	
15958	
15959	
15960	
15961	
15962	
15963	
15964	
15965	possible transcription factor. specifically binds to the ct/gc-rich region of the interleukin-3 promoter and mediates tax transactivation of il-3.
15966	plays an important role in the physiology of adrenergic neurons.
15967	
15968	
15969	
15970	responsible for cleaving the alpha-chains of c4b and c3b in the presence of the cofactors c4-binding protein and factor h respectively.
15971	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
15972	
15973	
15974	facilitative glucose transporter. probably a neuronal glucose transporter.
15975	
15976	
15977	
15978	
15979	
15980	
15981	may act as a scaffolding protein within caveolar membranes. interacts directly with g-protein alpha subunits and can functionally regulate their activity. caveolin-2 may function as an accessory protein in conjunction with caveolin-1.
15982	
15983	
15984	may act as a gtpase activating protein for rab family protein(s).
15985	binds gangliosides and stimulates ganglioside gm2 degradation. it stimulates only the breakdown of ganglioside gm2 and glycolipid ga2 by beta-hexosaminidase a. it extracts single gm2 molecules from membranes and presents them in soluble form to beta-hexosaminidase a for cleavage of n-acetyl-d-galactosamine and conversion to gm3.
15986	involved in the maturation of asn-linked oligosaccharides. trim alpha-1,2-linked mannose residues from man(9)glcnac(2) to produce first man(8)glcnac(2) then man(6)glcnac and a small amount of man(5)glcnac.
15987	binds to cug triplet repeat expansion dsrna (by similarity).
15988	
15989	
15990	
15991	
15992	rna-dependent atpase activity.
15993	involved in cytokinesis (potential).
15994	
15995	
15996	
15997	
15998	
15999	this is a receptor for corticotropin releasing factor. shows high-affinity crf binding. also binds to urocortin i, ii and iii. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
16000	
16001	
16002	
16003	plays a role in protein sorting and trafficking between the trans-golgi network (tgn) and endosomes. mediates the arf- dependent recruitment of clathrin to the tgn and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (ac-ll) motif.
16004	transcriptional regulator that probably plays an important role in lymphomagenesis.
16005	
16006	
16007	specialized low-affinity urea transporter. mediates urea transport in erythrocytes.
16008	
16009	
16010	
16011	
16012	
16013	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
16014	
16015	
16016	
16017	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
16018	
16019	
16020	
16021	
16022	
16023	
16024	
16025	
16026	
16027	
16028	
16029	
16030	
16031	
16032	
16033	
16034	
16035	
16036	
16037	
16038	
16039	may play a role in the cellular processing of insulin. may be involved in intercellular peptide signaling.
16040	the soluble isoform 2 binds vegf-165 and appears to inhibit its binding to cells. it may also induce apoptosis by sequestering vegf-165. may bind as well various members of the semaphorin family. its expression has an averse effect on blood vessel number and integrity.
16041	rna and ssdna-binding protein that may play specific roles during transcription initiation at distinct promoters. can enter the preinitiation complex together with the rna polymerase ii (pol ii).
16042	
16043	cellular role is not yet known.
16044	
16045	
16046	
16047	
16048	
16049	plays a role as an intracellular lectin in the early secretory pathway. interacts with n-acetyl-d-galactosamine and high-mannose type glycans and may also bind to o-linked glycans. involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (by similarity).
16050	
16051	
16052	
16053	
16054	in presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
16055	
16056	
16057	involved in high-affinity copper uptake.
16058	may act at junctions between the membrane and the cytoskeleton.
16059	integrin alpha-v/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von willebrand factor. integrin alpha-iib/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. integrins alpha-iib/beta-3 and alpha-v/beta-3 recognize the sequence r-g-d in a wide array of ligands. integrin alpha-iib/beta-3 recognizes the sequence h-h-l-g-g-g-a-k-q-a-g-d-v in fibrinogen gamma chain. following activation integrin alpha- iib/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. this step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
16060	
16061	
16062	
16063	stimulates the proliferation of mast cells. able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. mediates also cell-cell adhesion. acts synergistically with other cytokines, probably interleukins.
16064	collagen type iii occurs in most soft connective tissues along with type i collagen.
16065	
16066	
16067	
16068	
16069	
16070	
16071	
16072	
16073	
16074	sequence-specific rna-binding protein which participates in the control of pre-mrna splicing.
16075	
16076	
16077	
16078	
16079	
16080	
16081	
16082	
16083	
16084	
16085	
16086	
16087	
16088	promotes the exchange of ran-bound gdp by gtp. involved in the regulation of onset of chromosome condensation in the s phase. binds to the chromatin. rcc1/ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated dna.
16089	
16090	
16091	
16092	
16093	
16094	
16095	
16096	
16097	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
16098	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
16099	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release (by similarity). prevents constitutive tnfrsf1a signaling.
16100	
16101	
16102	
16103	
16104	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. may play an important physiological function in brain. may play a regulatory role by modulating the cellular levels of fatty acyl- coa ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. has broad specificity, active towards fatty acyl-coas with chain-lengths of c8-c18. has a maximal activity toward palmitoyl-coa.
16105	
16106	
16107	
16108	high affinity receptor for sphingosylphosphorylcholine, coupled to g proteins that stimulate phosphoinositide hydrolysis.
16109	
16110	
16111	
16112	
16113	
16114	
16115	transcriptional repressor.
16116	
16117	
16118	
16119	
16120	histone h3, along with histone h4, plays a central role in nucleosome formation.
16121	
16122	
16123	
16124	participates in the apoptotic response to dna damage. when overproduced, activates transcription from p53-responsive promoters and induces apoptosis. may be a tumor suppressor protein.
16125	
16126	adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. alpha adaptin is a subunit of the plasma membrane adaptor. binds polyphosphoinositides (by similarity).
16127	binds to tie2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. its function may be context-dependent. in the absence of angiogenic inducers, such as vegf, ang2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. in concert with vegf, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
16128	
16129	
16130	
16131	cytokine that binds to tnfrsf11b/opg and to tnfrsf11a/rank. osteoclast differentiation and activation factor. augments the ability of dendritic cells to stimulate naive t-cell proliferation. may be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
16132	
16133	
16134	
16135	
16136	
16137	transcriptional activator (by similarity). binds a gc box motif. could play a role in b-cell growth and development.
16138	
16139	
16140	
16141	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
16142	
16143	
16144	protein transport. probably involved in vesicular traffic (by similarity).
16145	
16146	orphan nuclear receptor. may regulate gene expression during the late phase of spermatogenesis.
16147	
16148	
16149	c-terminal alpha-amidation of peptides. the reaction produces a peptidyl(2-hydroxyglycine) intermediate is unstable and dismutates to glyoxylate and the corresponding desglycine peptide amide.
16150	
16151	could be a melanogenic enzyme (by similarity).
16152	
16153	
16154	involved in cytokinesis (potential).
16155	
16156	
16157	
16158	may play a functional role in the cell filament networks.
16159	involved in the protein trafficking from the golgi apparatus to the plasma membrane (by similarity).
16160	
16161	
16162	
16163	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. the alpha and alpha@#$%& chains contain the catalytic site. participates in wnt signaling. ck2 phosphorylates ser-392 of p53/tp53 following uv irradiation.
16164	
16165	
16166	stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal dna fragmentation.
16167	
16168	major airway glycoprotein.
16169	may play a fundamental role in situations where fine interplay between intracellular calcium and camp determines the cellular function. may be a physiologically relevant docking site for calcineurin (by similarity).
16170	
16171	
16172	
16173	
16174	
16175	this is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters. may be considered as a novel component of the nf-kappa-b signaling axis responsible for the survival and activation of b-cells after bcr cross-linking (by similarity).
16176	
16177	
16178	
16179	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
16180	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
16181	
16182	
16183	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. the n-terminus interacts with and regulates xpd whereas an intact c- terminus is required for a successful escape of rnap ii form the promoter.
16184	catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
16185	snare involved in a vesicular transport step within the golgi stack.
16186	
16187	involved in the presentation of foreign antigens to the immune system.
16188	
16189	
16190	guanine nucleotide exchange factor (gef) for rab-3 and cab-1. novel regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release. is also a regulator of the cab-1 synaptic transmission pathway.
16191	
16192	
16193	
16194	
16195	
16196	transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. potential role in g2/m cell cycle regulation (by similarity).
16197	
16198	
16199	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
16200	
16201	
16202	may be involved in zinc transport out of the cell.
16203	
16204	may be involved in transcriptional regulation.
16205	transcriptional repressor. binds to caccc-boxes promoter elements.
16206	
16207	
16208	
16209	
16210	involved in intracellular signal transduction mediated by cytokines and growth factors. when associated with stam, it suppresses dna signaling upon stimulation by il-2 and gm-csf. could be a direct effector of pi3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. may concentrate ubiquitinated receptors within clathrin-coated regions. involved in down- regulation of receptor tyrosine kinase via multivesicular body (mvbs) when complexed with stam. this complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. may contribute to the efficient recruitment of smads to the activin receptor complex.
16211	
16212	
16213	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. may be implicated in the folding, transport, and assembly of proteins. may play an important role in the regulation of pre-mrna splicing.
16214	docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. dok3 is a negative regulator of jnk signaling in b-cells through interaction with inpp5d/ship. may modulate abl function (by similarity).
16215	
16216	may play a role in regulating interactions between dynein and p150-glued, and the cellular substrates for dynein- mediated motility (such as organelles) (by similarity).
16217	
16218	
16219	may be involved in transcriptional regulation.
16220	positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (mrlc). it prevents mir-mediated mrlc ubiquitination and its subsequent proteasomal degradation.
16221	
16222	this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of sodium and potassium ions across the plasma membrane. this action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
16223	
16224	transcriptional repressor of genes that require a bhlh protein for their transcription. may act as a negative regulator of myogenesis by inhibiting the functions of myod1 and ash1 (by similarity).
16225	cleaves a-5@#$%&-ppp-5@#$%&a to yield amp and adp. possible tumor suppressor for specific tissues.
16226	specifically removes c-terminal basic residues (arg or lys) from peptides and proteins. it is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.
16227	
16228	
16229	provides cdp-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (ptdins), phosphatidylglycerol, and cardiolipin. overexpression may amplify cellular signaling responses from cytokines. may also play an important role in the signal transduction mechanism of retina and neural cells.
16230	
16231	may be signaling molecules that resemble neuropeptides. ligand for alpha-neurexins (by similarity).
16232	
16233	
16234	sodium-dependent and purine-selective. exhibits the transport characteristics of the nucleoside transport system cif or n1 subtype (n1/cif) (selective for purine nucleosides and uridine) (by similarity).
16235	
16236	
16237	
16238	
16239	
16240	
16241	
16242	
16243	
16244	involved in the degradation of prenylated proteins. cleaves the thioether bond of prenyl-l-cysteines, such as farnesylcysteine and geranylgeranylcysteine.
16245	stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal dna fragmentation.
16246	component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnrnp). hnrnp play an important role in processing of precursor mrna in the nucleus.
16247	
16248	thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. during neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (by similarity). slit1 and slit2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.
16249	essential for embryogenesis, including development of the placenta, heart and liver (by similarity). plays a role in transcriptional coactivation.
16250	
16251	
16252	general activator of rna polymerase iii transcription.
16253	
16254	
16255	type i collagen is a member of group i collagen (fibrillar forming collagen).
16256	probable helicase, which may be involved in rna maturation (by similarity).
16257	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the complex p170-eif3.
16258	
16259	
16260	
16261	
16262	reversible hydration of carbon dioxide.
16263	
16264	
16265	
16266	
16267	
16268	
16269	
16270	
16271	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
16272	
16273	
16274	
16275	
16276	
16277	
16278	mbp1 binds to the c-myc promoter and acts as a transcriptional repressor. may be a tumor suppressor.
16279	
16280	type i collagen is a member of group i collagen (fibrillar forming collagen).
16281	
16282	
16283	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
16284	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. rna polymerase i is essentially used to transcribe ribosomal dna units.
16285	
16286	helicase; has atpase activity.
16287	
16288	
16289	
16290	
16291	
16292	catalyzes the transfer of ptdins and phosphatidylcholine between membranes.
16293	
16294	
16295	
16296	
16297	
16298	
16299	
16300	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
16301	
16302	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
16303	required for protein transport from the er to the golgi complex.
16304	
16305	
16306	
16307	
16308	
16309	
16310	
16311	
16312	
16313	
16314	
16315	cleaves peptide bonds on the c-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
16316	
16317	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
16318	
16319	may be required for neuronal cell differentiation.
16320	binds to the sequences 5@#$%&-aatgtaggtca-3@#$%& and 5@#$%&- ataactaggtca-3@#$%&. acts as a potent competitive repressor of ror alpha function (by similarity).
16321	
16322	
16323	
16324	
16325	
16326	
16327	
16328	receptor for ptpns1. may play a role in membrane transport and/or signal transduction. may prevent premature elimination of red blood cells. may be involved in membrane permeability changes induced following virus infection. may play a role in memory formation. has a role in cell adhesion.
16329	
16330	calcium channel protein which plays an important role in excitation-contraction coupling.
16331	supports the intracellular pip pool and to a lesser extent, the pi 4,5-p(2) pool. it generates pip from pi and, to a lesser extent, pi 4,5-p(2) from pi 4-p. there are indications that it phosphorylates the d-5 rather than the d-4 position. has a role in endosome-related membrane trafficking (by similarity).
16332	may function as a transcription factor.
16333	plays a critical role in the generation of 28s rrna.
16334	
16335	
16336	
16337	actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells.
16338	
16339	
16340	
16341	
16342	activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (apc/c). during telophase and in the subsequent g1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (d-box) and an additional degradation signal termed the ken box including ase1, cdc20, the b-type cyclins clb2 and clb3, the polo-like kinase cdc5 and hsl1, and recruits them in a c-box-dependent manner to the apc/c for ubiquitination and subsequent proteolysis. required for exit from mitosis, cytokinesis and formation of prereplicative complexes in g1. probably is the target of a bub2-dependent spindle checkpoint pathway.
16343	may play a role in growth and differentiation of tissues involved in metabolic control. may play a regulatory role during g0/g1 transition of cell growth.
16344	iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones t(3) and t(4).
16345	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
16346	
16347	
16348	
16349	interconverts glcnac-6-p and glcnac-1-p.
16350	
16351	
16352	component of the gpi transamidase complex. essential for transfer of gpi to proteins, particularly for formation of carbonyl intermediates.
16353	
16354	
16355	
16356	rab effector protein acting as linker between gamma- adaptin, rab4a and rab5a. involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. stimulates rabgef1 mediated nucleotide exchange on rab5a.
16357	plays a role in cytoplasmic trafficking of rna. binds to the cis-acting response element, a2re.
16358	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
16359	calcium-dependent mitochondrial solute carrier (by similarity).
16360	required for learning most likely through its role in synaptic plasticity following nmda receptor signaling.
16361	subunit of the splicing factor sf3b required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex. belongs also to the minor u12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mrna intron.
16362	tyrosine kinase, that after binding to cdc42, inhibits both its intrinsic and stimulated gtpase activity.
16363	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes, such as ube2l3/ubcm4, and then transfers it to substrates.
16364	
16365	
16366	
16367	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
16368	
16369	
16370	may play a role in the regulation of plasmin-mediated matrix remodeling. inhibits trypsin, plasmin, factor viia/tissue factor and weakly factor xa. has no effect on thrombin.
16371	may be involved in n-glycosylation through its association with n-oligosaccharyl transferase.
16372	probable helicase, which may be involved in rna maturation (by similarity).
16373	
16374	
16375	cbf binds to the core site, 5@#$%&-pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, lck, il-3 and gm-csf promoters. the alpha subunit binds dna and appears to have a role in the development of normal hematopoiesis. isoform aml-1l interferes with the transactivation activity of runx1. acts synergistically with elf4 to transactivate the il-3 promoter and with elf2 to transactivate the mouse blk promoter. inhibits myst4- dependent transcriptional activation.
16376	
16377	receptor for neurturin. mediates the nrtn-induced autophosphorylation and activation of the ret receptor. also able to mediate gdnf signaling through the ret tyrosine kinase receptor.
16378	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex.
16379	muscle contraction.
16380	helicase; has atpase activity.
16381	co-chaperone of hsc70. seems to play a role in protein import into mitochondria.
16382	
16383	probably required for kinetochore function, involved in chromosome segregation during mitosis. interacts with retinoblastoma protein (rb), cenp-e and bubr1.
16384	
16385	
16386	attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to na-k atpase, to the lymphocyte membrane protein gp85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. in skeletal muscle, isoform mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
16387	
16388	
16389	may function as an output molecule from the suprachiasmatic nucleus (scn) that transmits behavioral circadian rhythm. may also function locally within the scn to synchronize output. potently contracts gastrointestinal (gi) smooth muscle (by similarity).
16390	
16391	receptor for a c-c type chemokine. binds to mip-1-alpha, mip-1-beta and rantes and subsequently transduces a signal by increasing the intracellular calcium ions level.
16392	may play a role in cell differentiation in the intestinal epithelium.
16393	
16394	
16395	drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively. binds f-actin.
16396	participates in wnt signaling (by similarity). plays a complex role in regulating the basal catalytic activity of the alpha subunit.
16397	
16398	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
16399	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
16400	may be involved in several stages of intracellular trafficking (by similarity).
16401	transcription factor that regulates cit2 gene expression. binds to two identical sites oriented as inverted repeats 28 bp apart in a regulatory upstream activation sequence element (uasr) in the cit2 promoter. the core binding site is 5@#$%&- ggtcac-3@#$%&.
16402	unknown.
16403	may be involved in protein transport from golgi to cell surface. the zdhhc9-golga7 complex is a palmitoyltransferase specific for hras and nras.
16404	transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. involved in particular in lens epithelial cell gene regulation and stress responses. may play an important role in lens epithelial to fiber cell terminal differentiation. may play a protective role during stress-induced apoptosis. isoform 2 is a more general and stronger transcriptional coactivator. isoform 2 may also act as an adapter to coordinate pre-mrna splicing. cellular cofactor for lentiviral integration.
16405	probably plays a role in facilitating the assembly of multimeric protein complexes inside the er.
16406	calcium-dependent, calmodulin-stimulated protein phosphatase. this subunit may have a role in the calmodulin activation of calcineurin.
16407	
16408	may be involved in the secretory process of mast cells and may play some role in signal transduction pathways.
16409	during embryonic development, some isoforms are essential for proper neuronal differentiation and organization. required for cell polarity; maintenance of apicobasal polarity. plays a critical role at septate junctions in cellular growth control during larval development. the presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
16410	important negative regulator in hematopoiesis and immune systems; may be involved in ending inflammatory responses through its inhibitory functions. inhibits endothelial nf-kappa-b signaling through a camp-dependent pathway. inhibits tnf-alpha- induced expression of endothelial adhesion molecules. involved in the control of fat metabolism and insulin sensitivity.
16411	
16412	
16413	
16414	functions in nuclear protein import as nuclear transport receptor. serves as receptor for nuclear localization signals (nls) in cargo substrates. is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (npc) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus (by similarity). mediates the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones.
16415	
16416	growth factor active on keratinocytes. possible major paracrine effector of normal epithelial cell proliferation.
16417	probable trna acetyltransferase required for the formation of the modified nucleoside n(4)-acetylcytidine in serine and leucine trnas. binds rna.
16418	
16419	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
16420	
16421	
16422	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling (by similarity).
16423	
16424	
16425	
16426	involved in transport from the endoplasmic reticulum to the golgi apparatus (by similarity).
16427	
16428	catalyzes the covalent attachment of ubiquitin to other proteins. mediates the selective degradation of short-lived and abnormal proteins. functions in the e6/e6-ap-induced ubiquitination of p53/tp53.
16429	
16430	
16431	
16432	
16433	
16434	
16435	orphan receptor.
16436	
16437	
16438	
16439	
16440	
16441	
16442	
16443	
16444	
16445	
16446	
16447	
16448	
16449	
16450	
16451	
16452	
16453	
16454	
16455	
16456	probably involved in the repair of mismatches in dna.
16457	this is a receptor for vip as well as pacap-38 and -27, the activity of this receptor is mediated by g proteins which activate adenylyl cyclase. can be coupled to phospholipase c.
16458	
16459	
16460	
16461	
16462	
16463	histone methyltransferase. specifically methylates lys-4 of histone h3, inducing di- and tri-methylation, but not monomethylation. plays an important role in transcriptional activation as a member of an rna polymerase complex.
16464	
16465	
16466	acts as a factor that allows the dna to undergo a single round of replication per cell cycle. required for the entry in s phase and for cell division.
16467	
16468	
16469	
16470	
16471	corepressor targeting diverse transcription regulators (by similarity).
16472	
16473	
16474	responsible for the synthesis of complex-type n-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
16475	
16476	
16477	
16478	
16479	
16480	
16481	involved in the presentation of foreign antigens to the immune system.
16482	
16483	
16484	
16485	
16486	
16487	
16488	
16489	
16490	
16491	
16492	
16493	plays an important role in the elongation step of protein synthesis.
16494	
16495	
16496	
16497	this protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
16498	
16499	
16500	
16501	probable transcription regulator.
16502	
16503	
16504	clathrin is the major protein of the polyhedral coat of coated pits and vesicles. two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-golgi network.
16505	
16506	
16507	
16508	
16509	
16510	
16511	
16512	
16513	
16514	
16515	
16516	transcriptional repressor.
16517	
16518	
16519	binds gtp, gdp and gmp.
16520	
16521	
16522	
16523	
16524	
16525	
16526	
16527	
16528	
16529	
16530	functions as an e1 enzyme essential for multisubstrates such as gabarapl1 and atg12. forms intermediate conjugates with gabarapl1 (gabarapl2, gabarap or map1alc3). formation of the final gabarapl1-pe conjugate is essential for autophagy (by similarity).
16531	has antibacterial activity (potential).
16532	
16533	
16534	
16535	
16536	
16537	
16538	antagonizes the binding of 2-5a (5@#$%&-phosphorylated 2@#$%&,5@#$%&-linked oligoadenylates) by rnase l through direct interaction with rnase l and therefore inhibits its endoribonuclease activity. may play a central role in the regulation of mrna turnover. antagonizes the anti-viral effect of the interferon-regulated 2-5a/rnase l pathway. may act as a chaperone for post-translational events during hiv-1 capsid assembly.
16539	general transcription factor. btf3 can form a stable complex with rna polymerase ii. required for the initiation of transcription.
16540	
16541	
16542	
16543	
16544	
16545	may be involved in transcriptional regulation.
16546	this protein may be a lipid transport protein in schwann cells.
16547	
16548	type i collagen is a member of group i collagen (fibrillar forming collagen).
16549	
16550	
16551	
16552	
16553	
16554	
16555	
16556	
16557	
16558	
16559	unknown.
16560	may function as an alternative splicing regulator. regulate its own expression at the level of rna processing. also regulates the splicing of fibronectin and cd45 genes. may act, at least in part, by interaction with other r/s-containing splicing factors.
16561	
16562	
16563	
16564	
16565	molecular chaperone; assists the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
16566	
16567	rapidly transports ca(2+) during excitation-contraction coupling. ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
16568	conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (dhea) and androstenedione. catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. involved in sexual development during fetal life and at puberty.
16569	
16570	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
16571	atp-dependent rna helicase which is a subunit of the eif4f complex involved in cap recognition and is required for mrna binding to ribosome. in the current model of translation initiation, eif4a unwinds rna secondary structures in the 5@#$%& untranslated region of mrnas which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
16572	
16573	
16574	single stranded dna-binding protein, with specificity to the sterol regulatory element (sre). involved in sterol-mediated repression.
16575	
16576	
16577	
16578	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
16579	
16580	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
16581	
16582	catalyzes the transfer of sulfate to position 4 of non- reducing n-acetylgalactosamine (galnac) residues in both n-glycans and o-glycans. participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. has a higher activity toward carbonic anhydrase vi than toward lutropin. only active against terminal galnacbeta1,galnacbeta. isoform 2, but not isoform 1, is active toward chondroitin.
16583	self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
16584	
16585	
16586	
16587	
16588	
16589	
16590	
16591	
16592	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
16593	
16594	
16595	
16596	
16597	may be involved in several stages of intracellular trafficking (by similarity).
16598	
16599	transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. retinyl esters are storage forms of vitamin a. lrat plays a critical role in vision. it provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.
16600	
16601	
16602	
16603	
16604	
16605	plays an essential role in autophagy (by similarity).
16606	
16607	
16608	required for larval development.
16609	
16610	
16611	
16612	
16613	
16614	
16615	
16616	has an effect on position-effect variegation.
16617	
16618	
16619	
16620	
16621	
16622	
16623	
16624	
16625	
16626	
16627	
16628	
16629	
16630	the ube2v2/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through lys- 63. this type of poly-ubiquitination does not lead to protein degradation by the proteasome. mediates transcriptional activation of target genes. plays a role in the control of progress through the cell cycle and differentiation. plays a role in the error-free dna repair pathway and contributes to the survival of cells after dna damage.
16631	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
16632	
16633	
16634	
16635	
16636	
16637	
16638	
16639	
16640	
16641	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
16642	
16643	
16644	may be involved in several stages of intracellular trafficking (by similarity).
16645	
16646	
16647	
16648	
16649	
16650	
16651	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
16652	
16653	
16654	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (by similarity). probably encodes a dihydropyridine-insensitive current. vital for survival to adulthood.
16655	
16656	this is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters. may be considered as a novel component of the nf-kappa-b signaling axis responsible for the survival and activation of b-cells after bcr cross-linking (by similarity).
16657	collagen type iii occurs in most soft connective tissues along with type i collagen.
16658	
16659	
16660	
16661	
16662	
16663	
16664	
16665	
16666	
16667	
16668	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
16669	
16670	
16671	
16672	
16673	
16674	
16675	
16676	
16677	
16678	probably involved in the repair of mismatches in dna.
16679	
16680	
16681	
16682	
16683	
16684	
16685	plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
16686	
16687	
16688	
16689	
16690	
16691	
16692	
16693	
16694	
16695	
16696	
16697	
16698	
16699	inhibitory regulator of the ras-cyclic amp pathway. stimulates the gtpase of normal but not oncogenic ras p21.
16700	
16701	
16702	
16703	
16704	
16705	
16706	
16707	
16708	
16709	required for protein transport from the er to the golgi complex.
16710	the electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- coa dehydrogenases, glutaryl-coa and sarcosine dehydrogenase. it transfers the electrons to the main mitochondrial respiratory chain via etf-ubiquinone oxidoreductase (etf dehydrogenase).
16711	
16712	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules (by similarity).
16713	
16714	
16715	
16716	inhibitor of the wnt signaling pathway. down-regulates beta-catenin. probably facilitate the phosphorylation of beta- catenin and apc by gsk3b (by similarity).
16717	
16718	
16719	
16720	
16721	
16722	
16723	type i collagen is a member of group i collagen (fibrillar forming collagen).
16724	
16725	
16726	
16727	may be important for the development of vital and immunocompetent organs.
16728	
16729	
16730	
16731	
16732	subunit of the integral membrane v0 complex of vacuolar atpase. vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.
16733	
16734	
16735	
16736	
16737	
16738	
16739	histone h3, along with histone h4, plays a central role in nucleosome formation.
16740	
16741	
16742	
16743	probably has no proteolytic activity, since crucial aa characteristic of serine proteases catalytic sites are not conserved.
16744	
16745	
16746	
16747	
16748	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
16749	
16750	
16751	
16752	
16753	
16754	
16755	
16756	hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. contributes to the native pacemaker currents in heart (if) and in neurons (ih). activated by camp, and at 10-100 times higher concentrations, also by cgmp. may mediate responses to sour stimuli.
16757	
16758	
16759	
16760	
16761	
16762	
16763	
16764	
16765	this is the smallest of the 5 chains of the enzymatic component (coupling factor cf(1)) of the mitochondrial atpase complex (by similarity).
16766	major high molecular weight protein of desmosomes. involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
16767	may be a dna-binding protein with a regulatory function. may play an important role in cell death and/or in regulation of cell proliferation.
16768	
16769	required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. cooperates with olig1 to establish the pmn domain of the embryonic neural tube. antagonist of v2 interneuron and of nkx2-2-induced v3 interneuron development (by similarity).
16770	may be implicated in endosomal trafficking, or microtubule dynamics, or both.
16771	
16772	
16773	
16774	
16775	
16776	
16777	
16778	in vitro, acts as a receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5).
16779	
16780	
16781	enhances ar-mediated transactivation. transactivation decreases as the poly-gln length within ar increases.
16782	
16783	
16784	
16785	
16786	
16787	
16788	
16789	transcriptional modulator activated by tgf-beta and activin type 1 receptor kinase. smad2 is a receptor-regulated smad (r-smad). may act as a tumor suppressor in colorectal carcinoma.
16790	
16791	
16792	
16793	
16794	transfers sialic acid from the donor of substrate cmp- sialic acid to galactose containing acceptor substrates.
16795	
16796	
16797	unknown. may have a key functions in the regulation of eye, tooth, brain and craniofacial development.
16798	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
16799	
16800	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
16801	
16802	
16803	
16804	
16805	
16806	
16807	
16808	
16809	
16810	
16811	
16812	
16813	
16814	transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. involved in particular in lens epithelial cell gene regulation and stress responses. may play an important role in lens epithelial to fiber cell terminal differentiation. may play a protective role during stress-induced apoptosis. isoform 2 is a more general and stronger transcriptional coactivator. isoform 2 may also act as an adapter to coordinate pre-mrna splicing. cellular cofactor for lentiviral integration.
16815	
16816	
16817	
16818	
16819	putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. preferentially binds to alpha2,6-linked sialic acid. the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. in the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their sh2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. induces apoptosis in acute myeloid leukemia (in vitro).
16820	
16821	
16822	
16823	microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. most probably involved in vesicular trafficking processes, in particular endocytosis.
16824	binds vldl and transports it into cells by endocytosis. in order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. binding to reelin induces tyrosine phosphorylation of dab1 and modulation of tau phosphorylation (by similarity).
16825	
16826	
16827	
16828	
16829	
16830	
16831	
16832	
16833	
16834	
16835	
16836	
16837	the protein is required for polarized cell growth.
16838	resistance to tetracycline by an active tetracycline efflux. this is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. this protein functions as a metal-tetracycline/h(+) antiporter.
16839	laminin-3 (s-laminin) regulates the formation of motor nerve terminals.
16840	
16841	
16842	
16843	
16844	inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin a. could play a role during central nervous system development (by similarity).
16845	
16846	
16847	
16848	
16849	
16850	
16851	
16852	
16853	
16854	
16855	
16856	
16857	
16858	may promote functional cell surface expression of olfactory receptors.
16859	
16860	
16861	
16862	suppresses neurite outgrowth (by similarity).
16863	
16864	essential component of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. when overexpressed in cells induces the formation of cytoplasmic annulate lamellae (al) (by similarity).
16865	
16866	
16867	
16868	can efficiently cleave only isg15 fusions including native isg15 conjugates linked via isopeptide bonds. necessary to maintain a critical cellular balance of isg15-conjugated proteins in both healthy and stressed organisms.
16869	
16870	
16871	
16872	
16873	
16874	
16875	binds to type i and ii regulatory subunits of protein kinase a and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
16876	
16877	
16878	
16879	
16880	
16881	
16882	
16883	
16884	
16885	
16886	3@#$%&-exoribonuclease that has a preference for poly(a) tails of mrnas, thereby efficiently degrading poly(a) tails. exonucleolytic degradation of the poly(a) tail is often the first step in the decay of eukaryotic mrnas and is also used to silence certain maternal mrnas translationally during oocyte maturation and early embryonic development. interacts with both the 3@#$%&-end poly(a) tail and the 5@#$%&-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(a) tails. involved in nonsense-mediated mrna decay, a critical process of selective degradation of mrnas that contain premature stop codons. also involved in degradation of inherently unstable mrnas that contain au-rich elements (ares) in their 3@#$%& untranslated regions, possibly via its interaction with khsrp. probably mediates the removal of poly(a) tails of ares mrnas, which constitutes the first step of destabilization.
16887	
16888	
16889	type i collagen is a member of group i collagen (fibrillar forming collagen).
16890	
16891	
16892	
16893	
16894	
16895	
16896	
16897	
16898	
16899	
16900	
16901	
16902	
16903	
16904	
16905	binds preferentially single-stranded dna and unwinds double stranded dna.
16906	plays a role in the formation of clathrin-coated invaginations and endocytosis.
16907	
16908	
16909	
16910	
16911	
16912	
16913	
16914	
16915	
16916	
16917	
16918	
16919	
16920	
16921	
16922	
16923	
16924	
16925	
16926	
16927	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
16928	
16929	suppresses neurite outgrowth (by similarity).
16930	
16931	
16932	
16933	
16934	
16935	
16936	has a transcriptional repressor activity by cooperating with epc1. induces apoptosis by activating jun n-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. may function in male germ cell development. has dna-binding activity and preferentially bound to double-stranded dna (by similarity).
16937	implicated in the early stage of ectopic ossification.
16938	chaperone. isoform 2 may function as an endogenous inhibitory regulator of hsc70 by competing the cochaperones.
16939	
16940	
16941	
16942	
16943	
16944	
16945	
16946	probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. is not an essential protein. involved in substrate recognition in ubiquitin-dependent degradation.
16947	
16948	
16949	
16950	
16951	
16952	in addition to its role as a glycolytic enzyme, it seems that pgk-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
16953	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
16954	
16955	
16956	
16957	may play a role in the apoptotic pathway or cell-cycle regulation induced by p53 after dna damage.
16958	has an important function as a repair enzyme for proteins that have been inactivated by oxidation. catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
16959	
16960	
16961	
16962	
16963	
16964	
16965	
16966	
16967	
16968	
16969	probable transcription regulator.
16970	involved in transcription regulation.
16971	
16972	
16973	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
16974	
16975	
16976	
16977	
16978	
16979	
16980	
16981	
16982	factor xiii is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
16983	
16984	
16985	
16986	
16987	
16988	
16989	
16990	signal-transducing molecule. the receptor systems for il6, lif, osm, cntf, il11, ctf1 and bsf3 can utilize gp130 for initiating signal transmission. binds to il6/il6r (alpha chain) complex, resulting in the formation of high-affinity il6 binding sites, and transduces the signal. does not bind il6. may have a role in embryonic development (by similarity).
16991	involved in the repair of mismatches in dna.
16992	
16993	
16994	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
16995	
16996	component of the cornified envelope of keratinocytes. may link the cornified envelope to desmosomes and intermediate filaments.
16997	
16998	
16999	
17000	
17001	
17002	
17003	
17004	
17005	
17006	binds pre-mrna and nucleates the assembly of 40s hnrnp particles. single hnrpc tetramers bind 230-240 nucleotides. trimers of hnrpc tetramers bind 700 nucleotides. may play a role in the early steps of spliceosome assembly and pre-mrna splicing. interacts with poly-u tracts in the 3@#$%& or 5@#$%& untranslated regions of mrna and modulates the stability and the level of translation of bound mrna molecules.
17007	
17008	
17009	
17010	among other substrates, acts on ysca (pep4) to activate it by processing its pro-peptide.
17011	
17012	may be involved in transcriptional regulation.
17013	
17014	
17015	
17016	likely to play a regulatory role in the development of the ventral forebrain. may play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (by similarity).
17017	
17018	type ii regulatory chains mediate membrane association by binding to anchoring proteins, including the map2 kinase.
17019	
17020	
17021	
17022	
17023	
17024	
17025	
17026	
17027	
17028	
17029	
17030	adapter molecule functioning in neural development. may regulate siah1 activity (by similarity).
17031	poly[adp-ribose] polymerase modifies various nuclear proteins by poly(adp-ribosyl)ation. the modification is dependent on dna and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from dna damage.
17032	
17033	unknown.
17034	
17035	
17036	
17037	
17038	
17039	
17040	
17041	
17042	
17043	
17044	
17045	
17046	
17047	
17048	
17049	the mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, zp1, zp2, zp3, and zp4. zp4 may act as a sperm receptor.
17050	
17051	
17052	
17053	involved in stress resistance and actin organization.
17054	
17055	
17056	
17057	
17058	
17059	rapidly transports ca(2+) during excitation-contraction coupling. ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
17060	
17061	
17062	
17063	
17064	
17065	
17066	
17067	
17068	
17069	
17070	may play a structural role at sites of cell adhesion in maintaining cell shape and motility. in addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. may be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
17071	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
17072	
17073	
17074	
17075	binds to the pu-box, a purine-rich dna sequence (5@#$%&- gaggaa-3@#$%&) that can act as a lymphoid-specific enhancer. this protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or b- cells. also binds rna and may modulate pre-mrna splicing (by similarity).
17076	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
17077	
17078	
17079	
17080	
17081	binds dna with high affinity. may also be involved in protein-protein interactions (by similarity).
17082	
17083	
17084	
17085	
17086	involved in cdc48-dependent protein degradation through the ubiquitin/proteasome pathway. direct or indirect positive regulator of glc7 activity.
17087	
17088	
17089	
17090	
17091	
17092	
17093	
17094	
17095	
17096	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
17097	
17098	
17099	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
17100	
17101	probable transcription regulator.
17102	
17103	
17104	
17105	
17106	catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a thr-glu-tyr sequence located in map kinases. activates the erk1 and erk2 map kinases.
17107	
17108	binds to gtp-bound form of rho and to profilin. acts in a rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. it is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics (by similarity).
17109	
17110	
17111	
17112	
17113	probably involved in connections of major cytoskeletal structures to the plasma membrane.
17114	
17115	
17116	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
17117	
17118	
17119	
17120	
17121	
17122	
17123	
17124	
17125	
17126	
17127	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. srp9 together with srp14 and the alu portion of the srp rna, constitutes the elongation arrest domain of srp. the complex of srp9 and srp14 is required for srp rna binding.
17128	
17129	
17130	
17131	
17132	
17133	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
17134	probably involved in a neuron-specific signal transduction.
17135	
17136	
17137	anchoring protein that mediates the subcellular compartmentation of protein kinase a (pka) and protein kinase c (pkc).
17138	acts as a negative coregulator for lim homeodomain transcription factors. via the recruitment of the sin3a/histone deacetylase corepressor complex.
17139	
17140	
17141	
17142	
17143	required for glial-neuronal cell interactions at the ventral midline which are necessary for the proper elaboration of commissures in the embryonic cns.
17144	this protein promotes the gtp-dependent binding of aminoacyl-trna to the a-site of ribosomes during protein biosynthesis.
17145	
17146	
17147	implicated in the control of cell fate decisions during development.
17148	
17149	
17150	
17151	
17152	
17153	
17154	
17155	
17156	
17157	
17158	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
17159	
17160	
17161	
17162	
17163	
17164	
17165	
17166	essential component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. recruits mitochondrial hsp70 to drive protein translocation into the matrix using atp as an energy source.
17167	
17168	
17169	may be involved in transcriptional regulation.
17170	
17171	
17172	catalyzes the covalent attachment of ubiquitin to other proteins. mediates the selective degradation of short-lived and abnormal proteins.
17173	
17174	may contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.
17175	
17176	
17177	
17178	
17179	
17180	
17181	
17182	
17183	
17184	
17185	
17186	
17187	inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin a. could play a role during central nervous system development.
17188	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
17189	
17190	
17191	
17192	also exhibits a dipeptidyl-peptidase iv type activity. in vitro, cleaves gly-pro-amc.
17193	calcium-dependent mitochondrial aspartate and glutamate carrier. may have a function in the urea cycle.
17194	
17195	
17196	modulates the activation of caspases during apoptosis. is a substrate for orgyia pseudotsugata multicapsid polyhedrosis virus (opmnpv) iap-mediated ubiquitination.
17197	
17198	
17199	
17200	
17201	major high molecular weight protein of desmosomes. involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
17202	eif-2 functions in the early steps of protein synthesis by forming a ternary complex with gtp and initiator trna. this complex binds to a 40s ribosomal subunit, followed by mrna binding to form a 43s preinitiation complex. junction of the 60s ribosomal subunit to form the 80s initiation complex is preceded by hydrolysis of the gtp bound to eif-2 and release of an eif-2-gdp binary complex. in order for eif-2 to recycle and catalyze another round of initiation, the gdp bound to eif-2 must exchange with gtp by way of a reaction catalyzed by eif-2b.
17203	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
17204	
17205	
17206	
17207	
17208	
17209	
17210	
17211	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
17212	
17213	
17214	may function as signal-transmitting receptor.
17215	
17216	probably plays a role in anchoring the complex to other cellular components.
17217	
17218	
17219	
17220	
17221	
17222	
17223	plays a role in cytoplasmic trafficking of rna. binds to the cis-acting response element, a2re.
17224	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (by similarity). this protein may be involved in maturation and/or post-transcriptional regulation of mrna. may play a role in control of cell cycle progression. may have tumor suppressor function. regulates dna topoisomerase ii binding protein (topbp1) for the dna damage response. plays an essential role in extraembryonic development.
17225	
17226	
17227	functions as a histone acetyltransferase (hat) to promote transcriptional activation. has significant histone acetyltransferase activity with core histones (h3 and h4), and also with nucleosome core particles. inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein e1a.
17228	promotes guanine-nucleotide exchange on arf1 and arf3. promotes the activation of arf1/arf3 through replacement of gdp with gtp.
17229	
17230	
17231	
17232	
17233	
17234	transcriptional activator which recognizes variations of the palindromic sequence 5@#$%&-attcccnngggaatt-3@#$%& (by similarity).
17235	
17236	
17237	
17238	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i.
17239	
17240	
17241	
17242	
17243	
17244	
17245	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
17246	
17247	
17248	
17249	
17250	
17251	
17252	
17253	plays a role in the sorting and targeting of vacuolar proteases.
17254	
17255	
17256	transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. cbf binds to the core site, 5@#$%&- pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(i) collagen, lck, il-3 and gm-csf promoters (by similarity). inhibits myst4-dependent transcriptional activation.
17257	
17258	
17259	
17260	
17261	
17262	
17263	
17264	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
17265	component c2 which is part of the classical pathway of the complement system is cleaved by activated factor c1 into two fragments: c2b and c2a. c2a, a serine protease, then combines with complement factor 4b to generate the c3 or c5 convertase.
17266	component c2 which is part of the classical pathway of the complement system is cleaved by activated factor c1 into two fragments: c2b and c2a. c2a, a serine protease, then combines with complement factor 4b to generate the c3 or c5 convertase.
17267	
17268	
17269	
17270	
17271	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
17272	
17273	
17274	
17275	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
17276	
17277	
17278	
17279	
17280	
17281	
17282	
17283	
17284	
17285	
17286	
17287	forms a channel through the mitochondrial outer membrane and also the plasma membrane. the channel allows diffusion of small hydrophilic molecules; it adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mv. the open state has a weak anion selectivity whereas the closed state is cation-selective. may participate in the formation of the permeability transition pore complex (ptpc) responsible for the release of mitochondrial products that triggers apoptosis.
17288	
17289	identifies cytotoxic/suppressor t-cells that interact with mhc class i bearing targets. cd8 is thought to play a role in the process of t-cell mediated killing. cd8 alpha chains binds to class i mhc molecules alpha-3 domains.
17290	
17291	activates erythroid-specific, globin gene expression.
17292	involved in transcriptional regulation as an activator.
17293	
17294	
17295	terminal component of the liver microsomal stearyl-coa desaturase system, that utilizes o(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-coa substrates including palmitoyl-coa and stearoyl-coa.
17296	part of the nucleoporin complex; required for correct nuclear pore assembly.
17297	
17298	
17299	
17300	component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. the nua4 complex atpase and helicase activities seem to be, at least in part, contributed by the association of ruvbl1 and ruvbl2 with ep400. nua4 may also play a direct role in dna repair when directly recruited to sites of dna damage. also component of the msin3a complex which acts to repress transcription by deacetylation of nucleosomal histones.
17301	
17302	
17303	
17304	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
17305	
17306	
17307	binds to scaffold/matrix attachment region (s/mar) dna and forms a molecular assembly point to allow the formation of a @#$%&transcriptosomal@#$%& complex (consisting of sr proteins and rna polymerase ii) coupling transcription and rna processing (by similarity). can function as an estrogen receptor corepressor and can also bind to the hsp27 promoter and decrease its transcription. can inhibit cell proliferation.
17308	
17309	
17310	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
17311	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
17312	
17313	
17314	
17315	
17316	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. srp9 together with srp14 and the alu portion of the srp rna, constitutes the elongation arrest domain of srp. the complex of srp9 and srp14 is required for srp rna binding.
17317	hydrolyzes n(g),n(g)-dimethyl-l-arginine (adma) and n(g)-monomethyl-l-arginine (mma) which act as inhibitors of nos. has therefore a role in nitric oxide generation.
17318	sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate (by similarity).
17319	
17320	
17321	
17322	induces apoptosis. interacts with viral and cellular anti-apoptosis proteins. can overcome the suppressors bcl-2 and bcl-xl, although high levels of bcl-xl expression will inhibit apoptosis. may function as a tumor suppressor.
17323	
17324	
17325	
17326	calcium-binding protein required for t-cell receptor-, fas-, and glucocorticoid-induced cell death. may mediate ca(2+)- regulated signals along the death pathway (by similarity).
17327	
17328	
17329	
17330	
17331	
17332	
17333	
17334	not known; binds gtp and exhibits intrinsic gtpase activity (by similarity).
17335	
17336	
17337	
17338	
17339	
17340	
17341	
17342	
17343	
17344	binds to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation. inhibits the phosphorylation of nucleosomal histones h3 and h2a by rps6ka5/msk1 and rps6ka3/rsk2 (by similarity).
17345	
17346	component of the sin3-repressing complex. enhances the ability of sin3-hdac1-mediated transcriptional repression. when tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins.
17347	
17348	
17349	
17350	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
17351	
17352	
17353	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
17354	
17355	
17356	
17357	
17358	
17359	
17360	
17361	
17362	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
17363	
17364	
17365	
17366	
17367	
17368	
17369	
17370	
17371	
17372	
17373	
17374	binds to splice sites in pre-mrna and regulates splice site selection. binds and stabilizes cytoplasmic mrna. contributes to the regulation of translation by modulating the interaction between the mrna and eukaryotic initiation factors (by similarity). binds to promoters that contain a y-box (5@#$%&- ctgattggccaa-3@#$%&), such as hla class ii genes. regulates the transcription of numerous genes. promotes separation of dna strands that contain mismatches or are modified by cisplatin. has endonucleolytic activity and can introduce nicks or breaks into double-stranded dna (in vitro). may play a role in dna repair.
17375	required for protein transport from the er to the golgi complex.
17376	polymerase alpha in a complex with dna primase is a replicative polymerase.
17377	
17378	
17379	
17380	as a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. recruits pip5k1c to focal adhesion plaques and strongly activates its kinase activity (by similarity).
17381	
17382	
17383	
17384	
17385	
17386	
17387	
17388	complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. also mediates erythropoiesis in vitro; but, unlike il-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. known to act on mmp-1, mmp-2, mmp-3, mmp-7, mmp-8, mmp-9, mmp-10, mmp-11, mmp-12, mmp-13 and mmp-16. does not act on mmp-14.
17389	
17390	ubiquitous transcription factor required for a diverse set of processes. it is a component of the ccr4 complex involved in the control of gene expression (by similarity).
17391	maintains high levels of reduced glutathione in the cytosol.
17392	
17393	as-c proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
17394	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
17395	
17396	
17397	
17398	catalyzes the covalent attachment of ubiquitin to other proteins (by similarity).
17399	
17400	
17401	
17402	
17403	
17404	
17405	
17406	
17407	
17408	the long isoform may play a role in neural and glial cell adhesion in the developing embryo. the short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. vital for embryonic development. essential for septate junctions. septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. required for the blood-brain barrier formation.
17409	
17410	
17411	
17412	
17413	
17414	
17415	
17416	
17417	
17418	
17419	
17420	
17421	
17422	
17423	
17424	
17425	
17426	
17427	
17428	
17429	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. the n-terminus interacts with and regulates xpd whereas an intact c- terminus is required for a successful escape of rnap ii form the promoter.
17430	may play an important role in palate formation.
17431	
17432	
17433	
17434	
17435	
17436	
17437	
17438	
17439	
17440	
17441	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
17442	
17443	
17444	not known. binds calcium.
17445	
17446	
17447	
17448	
17449	
17450	
17451	ligand for cd2. might facilitate interaction between activated lymphocytes. probably involved in regulating t-cell activation.
17452	orphan nuclear receptor.
17453	
17454	
17455	
17456	
17457	
17458	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
17459	
17460	
17461	unknown. has no cmp-n-acetylneuraminic acid (cmp-neu5ac) hydroxylase activity.
17462	
17463	might possibly play a role in rna metabolism.
17464	
17465	
17466	
17467	
17468	
17469	
17470	
17471	
17472	
17473	
17474	
17475	
17476	
17477	
17478	also exhibits a dipeptidyl-peptidase iv type activity. in vitro, cleaves gly-pro-amc.
17479	
17480	possible dna-binding subunit of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.
17481	
17482	
17483	
17484	
17485	
17486	
17487	
17488	
17489	
17490	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
17491	may be involved in transcriptional regulation.
17492	
17493	may be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.
17494	
17495	
17496	
17497	
17498	anti-proliferative protein inhibits cell cycle progression from the g0/g1 to s phases.
17499	may be involved in transcriptional regulation.
17500	
17501	
17502	
17503	
17504	
17505	
17506	
17507	
17508	putative odorant receptor.
17509	
17510	
17511	
17512	
17513	
17514	
17515	
17516	
17517	
17518	
17519	
17520	in vitro, acts as a receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5).
17521	
17522	
17523	
17524	
17525	
17526	
17527	acts as an adapter protein of the fyn and sh2-domain- containing leukocyte protein-76 (slp76) signaling cascades in t cells. modulates the expression of interleukin-2 (il-2).
17528	may be involved in transcriptional regulation.
17529	
17530	the function of subunit 3 is not clear.
17531	
17532	
17533	transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
17534	transcriptional corepressor. may specifically inhibit gene expression when recruited to promoter regions by sequence specific dna-binding proteins such as bcl6 and mllt3. this repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.
17535	
17536	
17537	
17538	
17539	plays a general role in the hierarchies of gene expression leading to metamorphosis.
17540	stimulates gdp/gtp exchange reaction of a group of small gtp-binding proteins (g proteins) including rap1a/rap1b, rhoa, rhob and kras, by stimulating the dissociation of gdp from and the subsequent binding of gtp to each small g protein.
17541	
17542	may play a role in testis development (by similarity).
17543	
17544	
17545	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
17546	
17547	
17548	
17549	
17550	
17551	
17552	
17553	transcription factor that regulates cit2 gene expression. binds to two identical sites oriented as inverted repeats 28 bp apart in a regulatory upstream activation sequence element (uasr) in the cit2 promoter. the core binding site is 5@#$%&- ggtcac-3@#$%&.
17554	dna-binding protein that binds to the 5@#$%&-aata[ct]-3@#$%& core sequence. probably acts as a transcription regulator. represses the cytomegalovirus enhancer. overexpression leads to induction of smooth muscle marker genes, suggesting that it may act as a regulator of smooth muscle cell differentiation and proliferation. may be involved in lipid stores.
17555	
17556	
17557	
17558	
17559	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
17560	functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (nls) in cargo substrates, or by acting as autonomous nuclear transport receptor. acting autonomously, serves itself as nls receptor. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran-dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. mediates autonomously the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in association with ipo7 mediates the nuclear import of h1 histone. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones.
17561	
17562	
17563	
17564	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
17565	
17566	catalyzes the covalent attachment of ubiquitin to other proteins (by similarity).
17567	
17568	
17569	
17570	may be involved in tissue-specific alternative rna processing events.
17571	may play a role in a signaling pathway regulating nuclear functions of cell proliferaration. phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
17572	
17573	
17574	
17575	
17576	
17577	
17578	
17579	implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2a, regulation of mrna trafficking and stability in association with elavl1, and inhibition of acetyltransferases as part of the inhat (inhibitor of histone acetyltransferases) complex.
17580	
17581	may play a role in transcriptional regulation. binds to and activates cyclin-dependent kinase cdk8 that phosphorylates the ctd (carboxy-terminal domain) of the large subunit of rna polymerase ii (rnap ii).
17582	
17583	
17584	
17585	
17586	
17587	
17588	
17589	
17590	
17591	
17592	
17593	
17594	
17595	
17596	
17597	
17598	crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. the beta-2 subunit causes an increase in the plasma membrane surface area and in its folding into microvilli. interacts with tnr may play a crucial role in clustering and regulation of activity of sodium channels at nodes of ranvier (by similarity).
17599	probable transcription regulator.
17600	
17601	
17602	
17603	
17604	
17605	
17606	
17607	associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. it may function in the assembly and/or transport of ribosome.
17608	
17609	
17610	
17611	
17612	
17613	
17614	may play a role in apoptosis by acting as a cell death substrate for caspases. is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. may be involved in the membrane ruffling process (by similarity).
17615	
17616	
17617	
17618	transcriptional repressor.
17619	
17620	
17621	
17622	
17623	
17624	
17625	
17626	e3 ring-finger protein, member of the ubc2/rad6 epistasis group. associates to the e2 ubiquitin conjugating enzyme ubc2/rad6 to form the ubc2-rad18 ubiquitin ligase complex involved in postreplicative repair (prr) of damaged dna. the ubc2-rad18 complex cooperates with rad5 and the ubc13-mms2 dimer to attach mono-ubiquitin chains on lys-164 of pol30, which is necessary for prr. the ubc2-rad18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine.
17627	
17628	
17629	
17630	
17631	
17632	could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by ngf. may be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (by similarity).
17633	
17634	collagen type iv is specific for basement membranes.
17635	
17636	
17637	
17638	
17639	
17640	
17641	
17642	
17643	
17644	converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single arg-val bond in plasminogen. by controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. play a direct role in facilitating neuronal migration.
17645	
17646	
17647	
17648	
17649	transcriptional regulator wich plays a central role in notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. acts as a transcriptional repressor when it is not associated with notch proteins. when associated with some notch protein, it acts as a transcriptional activator that activates transcription of notch target genes. probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. specifically binds to the immunoglobulin kappa-type j segment recombination signal sequence.
17650	
17651	binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
17652	
17653	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
17654	
17655	
17656	
17657	
17658	
17659	
17660	catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
17661	thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
17662	
17663	mediates estrogen action in various target organs.
17664	this is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. catalyzes the rate-limiting conversions of tyrosine to dopa, dopa to dopa-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
17665	
17666	
17667	
17668	
17669	
17670	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
17671	
17672	
17673	
17674	
17675	
17676	
17677	
17678	
17679	
17680	
17681	
17682	
17683	
17684	
17685	
17686	
17687	
17688	
17689	growth factor active on keratinocytes. possible major paracrine effector of normal epithelial cell proliferation.
17690	growth factor active on keratinocytes. possible major paracrine effector of normal epithelial cell proliferation.
17691	
17692	
17693	
17694	
17695	
17696	
17697	
17698	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the complex p170-eif3.
17699	
17700	may be involved in transcriptional regulation.
17701	
17702	
17703	
17704	
17705	represses transcription by binding to the bte site, a gc-rich dna element, in competition with the activator sp1. it also represses transcription by interacting with the corepressor sin3a and hdac1. activates rantes expression in t-cells.
17706	
17707	
17708	
17709	
17710	
17711	
17712	
17713	
17714	
17715	class-iii adh is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of s-(hydroxymethyl) glutathione.
17716	
17717	
17718	
17719	
17720	
17721	
17722	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
17723	
17724	
17725	
17726	molecular chaperone. has atpase activity (by similarity).
17727	
17728	transporter for the intake of folate. uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a v-type h(+)-pump.
17729	adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. binding of ap180 to clathrin triskelia induces their assembly into 60-70 nm coats.
17730	
17731	
17732	probable constituent of the synaptonemal complex during meiosis. may interact with red1.
17733	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
17734	
17735	binds avidly to the au-rich element in fos and il3/interleukin-3 mrnas. in the case of the fos au-rich element, hur binds to a core element of 27 nucleotides that contain auuua, auuuua, and auuuuua motifs.
17736	
17737	
17738	
17739	
17740	
17741	
17742	
17743	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
17744	
17745	
17746	
17747	
17748	
17749	
17750	
17751	
17752	
17753	
17754	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
17755	
17756	
17757	
17758	
17759	
17760	
17761	
17762	
17763	
17764	
17765	
17766	
17767	
17768	
17769	daughterless/achaete-scute complex heterodimers act as transcriptional activators of neural cell fates and are involved in sex determination.
17770	
17771	
17772	
17773	
17774	
17775	
17776	collagen type iv is specific for basement membranes.
17777	
17778	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
17779	required for protein transport from the er to the golgi complex.
17780	
17781	
17782	
17783	
17784	
17785	
17786	
17787	
17788	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
17789	
17790	
17791	
17792	
17793	high specificity for fatty acids. highest affinity for c18 chain length. decreasing the chain length or introducing double bonds reduces the affinity. may be involved in keratinocyte differentiation.
17794	
17795	
17796	
17797	
17798	
17799	
17800	
17801	
17802	
17803	
17804	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
17805	
17806	
17807	
17808	
17809	
17810	
17811	
17812	
17813	angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
17814	
17815	
17816	
17817	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
17818	
17819	
17820	
17821	
17822	
17823	
17824	possible adhesion molecule with a role in early hematopoiesis by mediating attachment to stromal cells. influences the survival and/or proliferation of b-cell precursors. binding to cells requires mn(2+) (by similarity).
17825	binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
17826	
17827	
17828	
17829	phosphorylates serine- and arginine-rich (sr) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable sr proteins to control rna splicing. phosphorylates serines, threonines and tyrosines (by similarity).
17830	
17831	
17832	phosphorylates serine- and arginine-rich (sr) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable sr proteins to control rna splicing. phosphorylates serines, threonines and tyrosines (by similarity).
17833	
17834	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
17835	
17836	
17837	participates in processes of transmission and amplification of the visual signal. cgmp-pdes are the effector molecules in g-protein-mediated phototransduction in vertebrate rods and cones.
17838	
17839	this small ubiquitous enzyme is essential for maintenance and cell growth.
17840	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
17841	
17842	
17843	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
17844	
17845	catalyzes the addition of n-acetylglucosamine in beta 1- 6 linkage to the alpha-linked mannose of biantennary n-linked oligosaccharides. it is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.
17846	
17847	catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine.
17848	
17849	
17850	
17851	
17852	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
17853	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction (by similarity).
17854	
17855	
17856	
17857	
17858	
17859	
17860	
17861	binds preferentially single-stranded dna and unwinds double stranded dna.
17862	
17863	key enzyme in the regulation of glycerol uptake and metabolism.
17864	
17865	
17866	
17867	
17868	the l3 protein is a component of the large subunit of cytoplasmic ribosomes.
17869	
17870	
17871	
17872	
17873	
17874	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
17875	
17876	essential for transcriptional activity of the hla class ii promoter; activation is via the proximal promoter. no dna binding of in vitro translated ciita was detected. may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal mhc class ii promoter, to elements of the transcription machinery, or both. alternatively it may activate hla class ii transcription by modifying proteins that bind to the mhc class ii promoter.
17877	
17878	
17879	associates with the organic matrix of bone and cartilage. thought to act as an inhibitor of bone formation.
17880	
17881	
17882	
17883	
17884	
17885	
17886	
17887	
17888	
17889	
17890	
17891	
17892	
17893	
17894	
17895	
17896	
17897	
17898	
17899	
17900	
17901	
17902	
17903	
17904	
17905	phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
17906	
17907	
17908	
17909	
17910	bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. has also low glutathione peroxidase activity with t- butyl and cumene hydroperoxides. is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.
17911	
17912	
17913	
17914	ribosomal protein p0 is the functional equivalent of e.coli protein l10.
17915	
17916	
17917	major cellular poly(rc)-binding protein. binds also poly(ru).
17918	
17919	
17920	
17921	
17922	possible dna-binding subunit of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.
17923	
17924	may be an ion-channel regulator. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis. involved in adhesive protein-protein and protein-carbohydrate interactions.
17925	may be an ion-channel regulator. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis. involved in adhesive protein-protein and protein-carbohydrate interactions.
17926	
17927	
17928	
17929	
17930	specifically binds to domain c of the tax-responsive enhancer element in the long terminal repeat of htlv-i.
17931	
17932	
17933	
17934	
17935	
17936	
17937	acts as a transcriptional repressor.
17938	
17939	part of a multiprotein post-splicing mrnp complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. binds spliced mrna upstream of exon-exon junctions.
17940	
17941	binds to wnt proteins and inhibits their activities. may be involved in mesoderm segmentation.
17942	
17943	
17944	
17945	
17946	
17947	
17948	
17949	
17950	
17951	
17952	not known. the authors believe that it may be involved in transmembrane signal transduction through a postulated calcium- binding function, but the evidence for the existence of a calcium- binding region is weak.
17953	isoform b has an accelerated gef-independent gdp/gtp exchange and an impaired gtp hydrolysis, which is restored partially by gtpase-activating proteins. it is able to bind to the gtpase-binding domain of pak but not full-length pak in a gtp- dependent manner, suggesting that the insertion does not completely abolish effector interaction.
17954	this is a receptor for interleukin-3.
17955	
17956	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
17957	
17958	
17959	
17960	
17961	
17962	
17963	
17964	
17965	
17966	
17967	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
17968	
17969	
17970	
17971	
17972	
17973	
17974	
17975	
17976	
17977	
17978	
17979	
17980	
17981	
17982	
17983	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
17984	
17985	
17986	
17987	
17988	
17989	may play a role in transporting nutrient from the gut lumen across the gutlining epithelial cell layer.
17990	
17991	
17992	
17993	
17994	
17995	binds the telomeric double-stranded ttaggg repeat and negatively regulates telomere length. involved in the regulation of the mitotic spindle.
17996	
17997	
17998	
17999	
18000	
18001	
18002	possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. presents carbohydrate ligands to selectins.
18003	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
18004	part of a post-splicing multiprotein complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity (by similarity).
18005	
18006	corepressor targeting diverse transcription regulators (by similarity).
18007	
18008	
18009	
18010	
18011	
18012	udpgt is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. this isoform has specificity for phenols.
18013	
18014	
18015	
18016	
18017	
18018	
18019	
18020	
18021	
18022	
18023	
18024	
18025	
18026	
18027	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
18028	
18029	
18030	
18031	
18032	
18033	
18034	binds to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation. inhibits the phosphorylation of nucleosomal histones h3 and h2a by rps6ka5/msk1 and rps6ka3/rsk2 (by similarity).
18035	
18036	
18037	may play a role in cell-cycle regulation during the transition from gamete to embryo.
18038	component of a protein kinase signal transduction cascade. activates the jnk, but not erk or p38 kinase pathways.
18039	melanocyte differentiation antigen. may transport substances required for melanin biosynthesis (by similarity).
18040	promotes the exchange of ras-bound gdp by gtp.
18041	
18042	
18043	
18044	
18045	
18046	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
18047	
18048	
18049	
18050	
18051	
18052	function in general translation initiation by promoting the binding of the formylmethionine-trna to ribosomes. seems to function along with eif-2.
18053	
18054	
18055	
18056	
18057	
18058	calcium-dependent mitochondrial solute carrier (by similarity).
18059	collagen type iv is specific for basement membranes.
18060	
18061	
18062	
18063	
18064	
18065	
18066	
18067	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
18068	
18069	
18070	
18071	
18072	
18073	
18074	
18075	this protein binds 5s rna.
18076	
18077	
18078	
18079	
18080	
18081	
18082	
18083	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
18084	
18085	
18086	
18087	
18088	
18089	
18090	
18091	
18092	
18093	
18094	
18095	
18096	
18097	
18098	
18099	
18100	transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. involved in particular in lens epithelial cell gene regulation and stress responses. may play an important role in lens epithelial to fiber cell terminal differentiation. may play a protective role during stress-induced apoptosis. isoform 2 is a more general and stronger transcriptional coactivator. isoform 2 may also act as an adapter to coordinate pre-mrna splicing. cellular cofactor for lentiviral integration.
18101	
18102	
18103	
18104	
18105	
18106	
18107	
18108	
18109	
18110	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
18111	
18112	
18113	binds the poly(a) tail of mrna.
18114	
18115	
18116	
18117	
18118	
18119	
18120	binds to pre-mrna. has high affinity for scaffold- attached region (sar) dna. bind to double- and single-stranded dna and rna.
18121	
18122	functions in segment determination through interaction with genes of bithorax (bx-c) and antennapedia (ant-c) complexes. it can behave as an activator of bx-c. involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. shown to bind zinc (in vitro).
18123	mbp1 binds to the c-myc promoter and acts as a transcriptional repressor. may be a tumor suppressor.
18124	
18125	
18126	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna.
18127	
18128	
18129	
18130	
18131	
18132	
18133	
18134	
18135	
18136	
18137	
18138	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
18139	
18140	
18141	
18142	
18143	
18144	acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. one of the activated genes is an inhibitor of cyclin-dependent kinases. apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of bcl-2 expression.
18145	
18146	
18147	
18148	
18149	
18150	
18151	
18152	
18153	
18154	
18155	
18156	
18157	
18158	
18159	
18160	
18161	transcription termination factor. binds to a 28 bp region within the trna(leu(uur)) gene at a position immediately adjacent to and downstream of the 16s rrna gene, this region comprises a tridecamer sequence critical for directing accurate termination. probably requires one or more components for termination activity.
18162	
18163	
18164	
18165	gtpase-activating protein for rac1 and cdc42. promotes the exchange of rac or cdc42-bound gdp by gtp, thereby activating them. displays serine/threonine kinase activity.
18166	
18167	
18168	
18169	general coactivator that functions cooperatively with tafs and mediates functional interactions between upstream activators and the general transcriptional machinery. binds single-stranded dna.
18170	
18171	
18172	
18173	
18174	
18175	
18176	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
18177	
18178	
18179	signaling adapter that couples activated growth factor receptors to signaling pathway. isoform p46shc and isoform p52shc, once phosphorylated, couple activated receptor tyrosine kinases to ras via the recruitment of the grb2/sos complex and are implicated in the cytoplasmic propagation of mitogenic signals. isoform p46shc and isoform p52shc may thus function as initiators of the ras signaling cascade in various nonneuronal systems. isoform p66shc does not mediate ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. isoform p66shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. the expression of isoform p66shc has been correlated with life span (by similarity).
18180	pair-rule protein that regulates embryonic segmentation and adult bristle patterning. transcriptional repressor of genes that require a bhlh protein for their transcription (e.g. the fushi tarazu gene).
18181	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
18182	
18183	
18184	
18185	involved in the presentation of foreign antigens to the immune system.
18186	
18187	
18188	
18189	
18190	
18191	binds to the 23s rrna (by similarity).
18192	
18193	
18194	
18195	
18196	
18197	glandular kallikreins cleave met-lys and arg-ser bonds in kininogen to release lys-bradykinin.
18198	
18199	
18200	
18201	may play a role in transporting nutrient from the gut lumen across the gutlining epithelial cell layer.
18202	
18203	
18204	
18205	
18206	
18207	
18208	
18209	may play a role in apoptosis by acting as a cell death substrate for caspases. is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. may be involved in the membrane ruffling process (by similarity).
18210	
18211	
18212	
18213	
18214	
18215	
18216	
18217	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
18218	
18219	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
18220	
18221	
18222	
18223	
18224	
18225	implicated in mitochondrial protein import and macromolecular assembly. may facilitate the correct folding of imported proteins. may also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
18226	
18227	
18228	
18229	binds the sequence 5@#$%&-atcaatcaa-3@#$%&. acts as a transcriptional activator of pf4 in complex with meis1. converted into a potent transcriptional activator by the (1;19) translocation. may have a role in steroidogenesis and, subsequently, sexual development and differentiation.
18230	
18231	electrically silent transporter system. mediates sodium and chloride reabsorption. plays a vital role in the regulation of ionic balance and cell volume.
18232	
18233	
18234	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes, such as ube2l3/ubcm4, and then transfers it to substrates.
18235	
18236	
18237	converts lysophosphatidic acid (lpa) into phosphatidic acid by incorporating acyl moiety at the 2 position.
18238	ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached.
18239	
18240	
18241	
18242	
18243	
18244	could function as a cell-adhesion protein. acts as a tumor suppressor. required for correct morphogenesis.
18245	
18246	this proteoglycan is a major component of extracellular matrix of cartilagenous tissues. a major function of this protein is to resist compression in cartilage. it binds avidly to hyaluronic acid via an n-terminal globular region.
18247	
18248	
18249	
18250	
18251	sequence-specific rna-binding protein that regulates translation and mrna stability by binding the 3@#$%& untranslated regions (utrs) of mrna targets. may be required to support proliferation and self-renewal of stem cells (by similarity).
18252	
18253	
18254	
18255	
18256	
18257	
18258	may play a role in regulating the early events of spermatogenesis by binding newly synthesized histones variants and transporting them to the nucleus.
18259	
18260	
18261	
18262	this protein is associated with sn-rnp u2. it helps the a@#$%& protein to bind stem loop iv of u2 snrna.
18263	transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
18264	
18265	
18266	induces the collapse and paralysis of neuronal growth cones. could potentially act as repulsive cues toward specific neuronal populations. binds to neuropilin (by similarity).
18267	
18268	
18269	
18270	
18271	
18272	
18273	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
18274	
18275	
18276	
18277	receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5), susceptibility to infection is correlated to its level of expression and availability at the plasma membrane of cells.
18278	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
18279	not known. may bind to chromatin.
18280	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
18281	
18282	
18283	
18284	
18285	
18286	
18287	
18288	
18289	
18290	
18291	
18292	
18293	
18294	
18295	may be able to bind plasminogen at cell surface and enhance plasminogen activation.
18296	
18297	
18298	
18299	
18300	ribosomal protein p0 is the functional equivalent of e.coli protein l10.
18301	
18302	
18303	
18304	
18305	the intermediate chains seem to help dynein bind to dynactin 150 kda component.
18306	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex. f6 seems to be part of the stalk that links cf(0) to cf(1). also involved in the restoration of oligomycin-sensitive atpase activity to depleted f1-f0 complexes.
18307	
18308	
18309	binds to g-rich structures in 28s rrna and in mrnas. plays a regulatory role in the translation apparatus; inhibits cell-free translation of mrnas.
18310	
18311	
18312	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
18313	
18314	transcriptional regulator that probably plays an important role in lymphomagenesis.
18315	
18316	maintains high levels of reduced glutathione in the cytosol.
18317	subunit of the splicing factor sf3b required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex. belongs also to the minor u12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mrna intron.
18318	probable transcriptional activator.
18319	
18320	
18321	
18322	
18323	
18324	
18325	
18326	
18327	
18328	collagen vi acts as a cell-binding protein.
18329	
18330	
18331	
18332	
18333	
18334	
18335	
18336	
18337	
18338	
18339	
18340	may mediate a process in spermatogenesis or may play a role in sex ratio distortion.
18341	
18342	
18343	
18344	
18345	
18346	
18347	membrane-cytoskeleton linker. the neural-specific isoforms may participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of ranvier and axonal initial segments.
18348	plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with rims1, rims2, cacna1d and cacna1b (by similarity).
18349	
18350	
18351	
18352	
18353	inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. receptor for dynorphins. may play a role in arousal and regulation of autonomic and neuroendocrine functions.
18354	
18355	
18356	hydrolyzes adenosine 5@#$%&-monophosphoramidate substrates such as amp-morpholidate, amp-n-alanine methyl ester, amp-alpha- acetyl lysine methyl ester and amp-nh2 (by similarity).
18357	
18358	type i collagen is a member of group i collagen (fibrillar forming collagen).
18359	
18360	
18361	
18362	
18363	
18364	
18365	
18366	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. binds poly(rg).
18367	required for the binding of mrna to ribosomes. functions in close association with eif4-f and eif4-a. binds near the 5@#$%&- terminal cap of mrna in presence of eif-4f and atp. promotes the atpase activity and the atp-dependent rna unwinding activity of both eif4-a and eif4-f.
18368	
18369	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
18370	
18371	required for the assembly of f-actin structures, such as stress fibers. depends on the rho-rock cascade for its activity. contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation.
18372	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
18373	
18374	
18375	repair polymerase. conducts @#$%!gap-filling@#$%! dna synthesis in a stepwise distributive fashion rather than in a processive fashion as for other dna polymerases. has a 5@#$%&-deoxyribose-5- phosphate lyase (drp lyase) activity.
18376	
18377	
18378	
18379	
18380	
18381	transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney (by similarity).
18382	
18383	
18384	cytotoxin and helminthotoxin. also induces noncytolytic histamine release from human basophils. involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. the proform acts as a proteinase inhibitor, reducing the activity of pappa.
18385	
18386	
18387	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
18388	plays a critical role in catalyzing the release of class ii hla-associated invariant chain-derived peptides (clip) from newly synthesized class ii hla molecules and freeing the peptide binding site for acquisition of antigenic peptides.
18389	
18390	
18391	
18392	
18393	transcription factor that binds to sequence with multiple copies of ttc[cg]g present in its own promoter and that of the hnrpa2b1 gene. down-regulates transcription of these genes. binds to the retinoic acid response element (rare) agggttcaccgaaagttca. activates the proenkephalin gene independently of promoter binding, probably through protein- protein interaction. when secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the g0 or g1 phase.
18394	
18395	
18396	
18397	
18398	may be involved in transcriptional regulation.
18399	la protein plays a role in the transcription of rna polymerase iii. it is most probably a transcription termination factor. binds to the 3@#$%& termini of virtually all nascent polymerase iii transcripts. it is associated with precursor forms of rna polymerase iii transcripts including trna and 4.5s, 5s, 7s, and 7-2 rnas.
18400	
18401	
18402	important modulator in the hla class ii restricted antigen presentation pathway by interaction with the hla-dm molecule.
18403	
18404	
18405	sodium-independent, high-affinity transport of large neutral amino acids. involved in cellular amino acid uptake.
18406	
18407	
18408	
18409	
18410	
18411	may be involved in both signal transduction and cellular adhesion in the cns.
18412	
18413	
18414	because s100a10 induces the dimerization of anxa2/p36, it may function as a regulator of protein phosphorylation in that the anxa2 monomer is the preferred target (in vitro) of tyrosine- specific kinase.
18415	it is required for normal cell growth and cell division.
18416	
18417	
18418	may play a role in apoptosis by acting as a cell death substrate for caspases. is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. may be involved in the membrane ruffling process (by similarity).
18419	
18420	
18421	
18422	
18423	
18424	
18425	
18426	
18427	
18428	
18429	this protein is a minor sialoglycoprotein in human erythrocyte membranes. the blood group gerbich antigens and receptors for plasmodium falciparum merozoites are most likely located within the extracellular domain. glycophorin c plays an important role in regulating the stability of red cells.
18430	
18431	
18432	
18433	binds the poly(a) tail of mrna. may be involved in cytoplasmic regulatory processes of mrna metabolism. its function in translational initiation regulation can either be enhanced by paip1 or repressed by paip2. can probably bind to cytoplasmic rna sequences other than poly(a) in vivo. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain.
18434	
18435	
18436	candidate for involvement in male sterility.
18437	histone demethylase that specifically demethylates lys-9 and lys-36 residues of histone h3, thereby playing a central role in histone code. does not demethylate histone h3 lys-4, h3 lys-27 nor h4 lys-20. demethylates trimethylated h3 lys-9 and h3 lys-36 residue, while it has no activity on mono- and dimethylated residues. demethylation of lys residue generates formaldehyde and succinate.
18438	
18439	c7 is a constituent of the membrane attack complex. c7 binds to c5b forming the c5b-7 complex, where it serves as a membrane anchor.
18440	
18441	
18442	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. probably binds g- rich sequences in pre-mrnas.
18443	
18444	type i collagen is a member of group i collagen (fibrillar forming collagen).
18445	collagen type iii occurs in most soft connective tissues along with type i collagen.
18446	aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
18447	
18448	
18449	
18450	
18451	
18452	
18453	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
18454	
18455	may regulate the transcription of specific genes during normal development. may play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. implicated in the transduction of shh signal (by similarity).
18456	
18457	
18458	
18459	
18460	
18461	
18462	
18463	
18464	
18465	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
18466	tyrosine-protein kinase receptor whose role is not yet clear.
18467	
18468	central component of the spliceosome, which may play a role in aligning the pre-mrna 5@#$%& and 3@#$%& exons for ligation. interacts with u5 snrna, and with pre-mrna 5@#$%& splice sites in b spliceosomes and 3@#$%& splice sites in c spliceosomes.
18469	
18470	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. this component is involved in redox-linked proton pumping.
18471	
18472	
18473	
18474	
18475	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
18476	
18477	
18478	
18479	
18480	
18481	
18482	
18483	
18484	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
18485	
18486	
18487	
18488	forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. the channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mv. the open state has a weak anion selectivity whereas the closed state is cation- selective.
18489	
18490	
18491	
18492	
18493	downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small gtpases to the actin cytoskeleton.
18494	
18495	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
18496	
18497	
18498	
18499	
18500	
18501	
18502	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
18503	
18504	
18505	
18506	
18507	clathrin is the major protein of the polyhedral coat of coated pits and vesicles. two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-golgi network.
18508	
18509	
18510	
18511	
18512	
18513	
18514	
18515	
18516	
18517	
18518	sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate (by similarity).
18519	
18520	
18521	
18522	plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity.
18523	
18524	could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. may contribute to the metastatic phenotype.
18525	
18526	
18527	required only in the female germ line. it is important for oocyte formation and in the specification of the posterior structures of the embryo.
18528	may have a role in processing of pre-rrna or in the assembly of rrna into ribosomal subunits.
18529	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
18530	
18531	
18532	may be involved in transcriptional regulation.
18533	binds and presumably selects ubiquitin-conjugates for destruction. displays selectivity for longer polyubiquitin chains. modulates intestinal fluid secretion.
18534	
18535	
18536	
18537	
18538	type i collagen is a member of group i collagen (fibrillar forming collagen).
18539	implicated in the suppression of cell death. interacts with the bcl-2 and adenovirus e1b 19 kda proteins (by similarity).
18540	anti-proliferative protein.
18541	
18542	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
18543	
18544	
18545	
18546	
18547	
18548	
18549	
18550	
18551	
18552	
18553	collagen type iii occurs in most soft connective tissues along with type i collagen.
18554	this protein promotes the gtp-dependent binding of aminoacyl-trna to the a-site of ribosomes during protein biosynthesis.
18555	
18556	
18557	
18558	binds specifically to nuclear core particles and acts as a transcriptional activator (by similarity).
18559	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
18560	responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase a). it catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (by similarity).
18561	
18562	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
18563	
18564	
18565	
18566	
18567	
18568	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
18569	
18570	
18571	
18572	
18573	
18574	
18575	signal-transducing molecule. the receptor systems for il6, lif, osm, cntf, il11, ctf1 and bsf3 can utilize gp130 for initiating signal transmission. binds to il6/il6r (alpha chain) complex, resulting in the formation of high-affinity il6 binding sites, and transduces the signal. does not bind il6. may have a role in embryonic development (by similarity).
18576	
18577	binds galactosides. may play a role in thymocyte- epithelial interactions relevant to the biology of the thymus. the isoform short acts as an eosinophil chemoattractant. is a ligand for havcr2/tim3. induces t-helper type 1 lymphocyte (th1) death.
18578	
18579	
18580	
18581	
18582	may be involved in transcriptional regulation.
18583	interacts with the e6 protein of the cancer-associated human papillomavirus types 16 and 18. the e6/e6-ap complex binds to and targets the p53 tumor-suppressor protein for ubiquitin- mediated proteolysis. it is an e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. it can target itself for ubiquitination in vitro and efficiently promotes its own degradation in vivo. it appears that only unmodified e6-ap molecules can bind efficiently to p53 in the presence of the hpv e6 oncoprotein.
18584	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis (by similarity).
18585	
18586	splicing factor that in its dephosphorylated form acts as a general repressor of pre-mrna splicing. seems to interfere with the u1 snrnp 5@#$%&-splice recognition of snrp70. required for splicing repression in m-phase cells and after heat shock. may be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
18587	
18588	
18589	interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. can also catalyze the reaction of ec 5.4.2.4 (synthase) and ec 3.1.3.13 (phosphatase), but with a reduced activity.
18590	type i collagen is a member of group i collagen (fibrillar forming collagen).
18591	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
18592	may play an important role in fibrillogenesis by controlling lateral growth of collagen ii fibrils.
18593	
18594	
18595	may act as a specific coactivator for the mammalian tefs. may play a role in the development of skeletal muscles.
18596	
18597	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
18598	
18599	
18600	
18601	involved in ph regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. major proton extruding system driven by the inward sodium ion chemical gradient. plays an important role in signal transduction (by similarity).
18602	major high molecular weight protein of desmosomes. involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
18603	
18604	
18605	
18606	
18607	
18608	
18609	
18610	mediates rac1-dependent reorganization of actin filaments (by similarity). participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
18611	
18612	
18613	
18614	
18615	
18616	
18617	
18618	
18619	putative odorant receptor.
18620	
18621	
18622	
18623	
18624	
18625	
18626	hydrolyzes adenosine 5@#$%&-monophosphoramidate substrates such as amp-morpholidate, amp-n-alanine methyl ester, amp-alpha- acetyl lysine methyl ester and amp-nh2 (by similarity).
18627	
18628	factor ix is a vitamin k-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor x to its active form in the presence of ca(2+) ions, phospholipids, and factor viiia.
18629	
18630	
18631	
18632	facilitative glucose transporter. probably a neuronal glucose transporter.
18633	
18634	
18635	
18636	
18637	
18638	
18639	
18640	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. binds poly(rg).
18641	receptor for sema4d. plays a role in rhoa activation and subsequent changes of the actin cytoskeleton. plays a role in axon guidance, invasive growth and cell migration.
18642	
18643	
18644	
18645	
18646	thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. in vitro it binds mhc, f-actin and native thin filaments, and modifies the activity of actin-activated myosin atpase. it may modulate muscle contraction or may play a more structural role.
18647	
18648	
18649	
18650	
18651	
18652	
18653	tautomerization of d-dopachrome with decarboxylation to give 5,6-dihydroxyindole (dhi).
18654	
18655	
18656	
18657	associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. it may function in the assembly and/or transport of ribosome.
18658	this protein promotes the gtp-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome.
18659	in addition to gelatin and collagens, it cleaves kiss1 at a gly-|-leu bond.
18660	factor h functions as a cofactor in the inactivation of c3b by factor i and also increases the rate of dissociation of the c3bbb complex (c3 convertase) and the (c3b)nbb complex (c5 convertase) in the alternative complement pathway.
18661	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
18662	
18663	
18664	
18665	
18666	
18667	orphan receptor.
18668	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. may play a role in cftr trafficking to the plasma membrane. causes the formation of thin, actin-rich surface projections called filopodia.
18669	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. may play a role in cftr trafficking to the plasma membrane. causes the formation of thin, actin-rich surface projections called filopodia.
18670	
18671	
18672	
18673	
18674	molecular chaperone; assists the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
18675	
18676	potent inhibitor of the complement membrane attack complex (mac) action. acts by binding to the c8 and/or c9 complements of the assembling mac, thereby preventing incorporation of the multiple copies of c9 required for complete formation of the osmolytic pore. this inhibitor appears to be species-specific. involved in signal transduction for t-cell activation complexed to a protein tyrosine kinase.
18677	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
18678	
18679	
18680	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
18681	
18682	
18683	
18684	
18685	enhances ar-mediated transactivation. transactivation decreases as the poly-gln length within ar increases.
18686	the muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of g proteins. primary transducing effect is adenylate cyclase inhibition.
18687	could be involved in oogenesis. involved in the regulation of endosome dynamics. implicated in a novel signal transduction pathway, in which isoform 3 and csk are sequentially activated by rhod to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
18688	
18689	
18690	
18691	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
18692	
18693	
18694	
18695	
18696	
18697	
18698	
18699	
18700	
18701	
18702	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb.
18703	binds to pre-mrna. has high affinity for scaffold- attached region (sar) dna. bind to double- and single-stranded dna and rna.
18704	
18705	
18706	
18707	
18708	
18709	
18710	may play a role in anchoring the cytoskeleton to the plasma membrane (by similarity to dystrophin).
18711	
18712	type i collagen is a member of group i collagen (fibrillar forming collagen).
18713	
18714	
18715	
18716	
18717	
18718	
18719	
18720	
18721	
18722	necessary for scanning and involved in initiation site selection. promotes the assembly of 48s ribosomal complexes at the authentic initiation codon of a conventional capped mrna.
18723	involved in signal transduction through the wnt pathway.
18724	
18725	
18726	
18727	
18728	
18729	
18730	
18731	
18732	
18733	
18734	
18735	
18736	
18737	
18738	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. this protein may mediate formation of the complex between cytochromes c and c1.
18739	
18740	may act as a gtpase activating protein for rab family protein(s).
18741	
18742	
18743	
18744	
18745	gtpase-activating protein for rhoa, and perhaps for cdc42. may be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. acts a tumor suppressor in hepatocellular carcinoma cells.
18746	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
18747	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
18748	may be involved in transcriptional regulation.
18749	molecular chaperone; assists the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
18750	
18751	
18752	
18753	
18754	
18755	
18756	
18757	
18758	may be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.
18759	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
18760	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
18761	
18762	
18763	
18764	
18765	
18766	
18767	
18768	
18769	
18770	
18771	
18772	
18773	
18774	
18775	
18776	
18777	
18778	
18779	
18780	
18781	
18782	
18783	
18784	probable histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a central role in histone code. demethylation of lys residue generates formaldehyde and succinate. may be involved in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes (by similarity).
18785	
18786	
18787	
18788	
18789	conversion of folates to polyglutamate derivatives. this allows tissues to concentrate folate at higher levels than in plasma.
18790	
18791	
18792	probably involved in the repair of mismatches in dna.
18793	
18794	
18795	
18796	
18797	
18798	
18799	its physiological substrate seems to be the small heat shock protein (hsp27/hsp25). in vitro can phosphorylate glycogen synthase at ser-7 and tyrosine hydroxylase (on ser-19 and ser-40). this kinase phosphorylates ser in the peptide sequence, hyd-x-r- x(2)-s, where hyd is a large hydrophobic residue (by similarity). mediates both erk and p38 mapk/mapk14 dependent neutrophil responses. participates in tnf alpha-stimulated exocytosis of secretory vesicles in neutrophils. plays a role in phagocytosis- induced respiratory burst activity.
18800	
18801	
18802	
18803	
18804	produces nitric oxide (no) which is a messenger molecule with diverse functions throughout the body. in macrophages, no mediates tumoricidal and bactericidal actions.
18805	
18806	
18807	
18808	
18809	
18810	
18811	
18812	
18813	
18814	
18815	
18816	receptor for activated thrombin coupled to g proteins that stimulate phosphoinositide hydrolysis.
18817	
18818	
18819	putative transcription factor involved in pancreas development and function.
18820	
18821	
18822	
18823	
18824	
18825	
18826	
18827	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
18828	
18829	
18830	
18831	
18832	
18833	
18834	
18835	
18836	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
18837	
18838	
18839	component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to atp synthesis.
18840	
18841	
18842	
18843	catalyzes the posttranslational formation of 4- hydroxyproline in -xaa-pro-gly- sequences in collagens and other proteins.
18844	
18845	
18846	
18847	
18848	
18849	
18850	
18851	
18852	involved in the transduction of mitogenic signals from the cell membrane to the nucleus.
18853	
18854	
18855	
18856	
18857	
18858	dual specificity kinase that activates the jun kinases mapk8 (jnk1) and mapk9 (jnk2) as well as mapk14 (p38) but not mapk1 (erk2) or mapk3 (erk1).
18859	
18860	
18861	key enzyme for ketone body catabolism. transfers the coa moiety from succinate to acetoacetate. formation of the enzyme-coa intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
18862	
18863	
18864	
18865	
18866	
18867	
18868	
18869	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
18870	contributes to the lung@#$%&s defense against inhaled microorganisms. binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. it could participate in the extracellular reorganization or turnover of pulmonary surfactant.
18871	
18872	
18873	potential tumor suppressor for renal cell carcinoma.
18874	
18875	
18876	
18877	binds to gtp-bound form of rho and to profilin. acts in a rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. it is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics (by similarity).
18878	
18879	
18880	
18881	
18882	
18883	
18884	
18885	
18886	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
18887	
18888	
18889	
18890	
18891	
18892	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
18893	
18894	may function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment (by similarity).
18895	
18896	implicated in development of nervous system and pancreatic endocrine cells.
18897	
18898	
18899	
18900	
18901	
18902	
18903	
18904	
18905	
18906	
18907	
18908	seems to act exclusively upon threonine residues (by similarity).
18909	
18910	
18911	
18912	transcriptional repressor.
18913	
18914	
18915	
18916	
18917	
18918	does not act as an allosteric activator of the cholera toxin catalytic subunit (by similarity).
18919	
18920	
18921	
18922	
18923	transcriptional regulator that acts as repressor or activator. binds, in-vitro, to nf-e2 binding sites. play important roles in coordinating transcription activation and repression by mafk.
18924	
18925	
18926	
18927	
18928	
18929	
18930	aminopeptidase n is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
18931	dna polymerase specifically involved in dna repair. plays an important role in translesion synthesis, where the normal high fidelity dna polymerases cannot proceed and dna synthesis stalls. plays an important role in the repair of uv-induced pyrimidine dimers. depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. may play a role in hypermutation at immunoglobulin genes. forms a schiff base with 5@#$%&-deoxyribose phosphate at abasic sites, but does not have lyase activity. targets poli to replication foci.
18932	binds highly specifically to rhoa, rhoc and rac proteins, but does not appear to catalyze guanine nucleotide exchange (by similarity).
18933	
18934	
18935	
18936	
18937	
18938	
18939	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
18940	may act as receptor for class i mhc antigens.
18941	
18942	
18943	
18944	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. may play a role in cftr trafficking to the plasma membrane. causes the formation of thin, actin-rich surface projections called filopodia.
18945	complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. known to act on mmp-1, mmp-2, mmp-3, mmp-7 and mmp-9.
18946	
18947	has e3 ubiquitin protein ligase activity. regulates the levels of casp8 and casp10 by targeting them for proteasomal degradation. protects cells against apoptosis induced by tnf. binds phosphatidylinositol-5-phosphate and phosphatidylinositol-3- phosphate.
18948	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l.
18949	
18950	
18951	
18952	
18953	
18954	transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (by similarity).
18955	transcription factor that binds specifically to the distal ras-responsive element (rre) in the calcitonin gene promoter and augment the ras/raf-mediated transcriptional response of that promoter. may be involved in ras/raf-mediated cell differentiation.
18956	
18957	unknown.
18958	
18959	
18960	
18961	
18962	
18963	
18964	
18965	
18966	
18967	
18968	
18969	
18970	part of the complex catalyzing the transfer of n- acetylglucosamine from udp-n-acetylglucosamine to phosphatidylinositol, the first step of gpi biosynthesis.
18971	
18972	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. the n-terminus interacts with and regulates xpd whereas an intact c- terminus is required for a successful escape of rnap ii form the promoter.
18973	
18974	
18975	
18976	ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. this enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the c-terminal glycine of ubiquitin. also binds to free monoubiquitin and may prevent its degradation in lysosomes. the homodimer may have atp-independent ubiquitin ligase activity.
18977	component of a protein kinase signal transduction cascade. regulates the jnk and erk5 pathways by phosphorylating and activating map2k5 and map2k7. plays a role in caveolae kiss- and-run dynamics (by similarity).
18978	
18979	
18980	
18981	
18982	catalyzes the covalent attachment of ubiquitin to other proteins (by similarity).
18983	
18984	
18985	
18986	
18987	
18988	
18989	
18990	
18991	
18992	
18993	
18994	
18995	
18996	
18997	
18998	
18999	
19000	type i collagen is a member of group i collagen (fibrillar forming collagen).
19001	
19002	
19003	
19004	
19005	
19006	
19007	
19008	rna-binding protein. required for internal initiation of translation of human rhinovirus rna. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain.
19009	
19010	
19011	
19012	
19013	type i collagen is a member of group i collagen (fibrillar forming collagen).
19014	
19015	
19016	
19017	
19018	
19019	
19020	
19021	
19022	may be involved in adhesive interactions of activated t and nk cells during the late phase of the immune response. may function at a time after t and nk cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
19023	
19024	
19025	may play a role in transcriptional regulation. in vitro, is associated with a kinase activity toward both rna polymerase ii c-terminal domain and cdk2 (cak).
19026	
19027	
19028	
19029	
19030	
19031	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
19032	
19033	
19034	
19035	
19036	
19037	
19038	
19039	
19040	
19041	
19042	
19043	implicated in mitochondrial protein import and macromolecular assembly. may facilitate the correct folding of imported proteins. may also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
19044	
19045	
19046	
19047	
19048	
19049	
19050	
19051	
19052	
19053	
19054	
19055	collagen type iii occurs in most soft connective tissues along with type i collagen.
19056	
19057	
19058	
19059	
19060	
19061	
19062	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
19063	
19064	involved in double-stranded break repair. plays a central role in genetic recombination and dna repair by promoting the annealing of complementary single-stranded dna and by stimulation of the rad51 recombinase.
19065	
19066	
19067	
19068	
19069	
19070	microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. most probably involved in vesicular trafficking processes, in particular endocytosis.
19071	high affinity receptor for semaphorins 3c, 3f, vegf-165 and vegf-145 isoforms of vegf, and the plgf-2 isoform of pgf.
19072	
19073	
19074	destroys radicals which are normally produced within the cells and which are toxic to biological systems.
19075	
19076	
19077	binds to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation. inhibits the phosphorylation of nucleosomal histones h3 and h2a by rps6ka5/msk1 and rps6ka3/rsk2 (by similarity).
19078	
19079	
19080	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression.
19081	
19082	transcriptional activator that binds to dna sequences containing the consensus pentanucleotide 5@#$%&-cgga[at]-3@#$%&.
19083	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
19084	
19085	
19086	this is a receptor for glucagon-like peptide 2. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
19087	
19088	
19089	
19090	collagen type iii occurs in most soft connective tissues along with type i collagen.
19091	
19092	stimulates exchange activity on rho proteins in vitro, but not on cdc42, ras or rac. may bind calcium ions.
19093	
19094	
19095	muscle contraction.
19096	
19097	catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of nad. it is the rate limiting component in the mammalian nad biosynthesis pathway (by similarity).
19098	implicated in development of nervous system and pancreatic endocrine cells.
19099	probably involved in nervous system development and function.
19100	involved in cytokinesis (potential).
19101	
19102	
19103	
19104	
19105	
19106	may have a role in processing of pre-rrna or in the assembly of rrna into ribosomal subunits.
19107	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
19108	
19109	
19110	orphan nuclear receptor.
19111	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
19112	
19113	forms transcriptional repressor complexes by associating with mad, sin3, yy1 and n-cor. interacts in the late s-phase of dna-replication with dnmt1 in the other transcriptional repressor complex composed of dnmt1, dmap1, pcna, caf1.
19114	
19115	
19116	probable zinc protease. may mediate cell-cell or cell- matrix interactions. isoform 2 displays alpha-secretase activity for app.
19117	does not act as an allosteric activator of the cholera toxin catalytic subunit (by similarity).
19118	
19119	
19120	plays an adhesive role by integrating collagen bundles. it is probably associated with the surface of interstitial collagen fibrils via col1. the col2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large n-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (by similarity).
19121	
19122	
19123	
19124	
19125	
19126	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
19127	
19128	
19129	
19130	
19131	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
19132	
19133	
19134	
19135	
19136	
19137	required for protein transport from the er to the golgi complex.
19138	
19139	
19140	
19141	
19142	
19143	
19144	
19145	
19146	methylates cpg residues. preferentially methylates hemimethylated dna. it is responsible for maintaining methylation patterns established in development. mediates transcriptional repression by direct binding to hdac2.
19147	
19148	
19149	
19150	
19151	
19152	
19153	
19154	
19155	
19156	
19157	
19158	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
19159	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
19160	
19161	
19162	
19163	
19164	
19165	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. may play a role in cftr trafficking to the plasma membrane. causes the formation of thin, actin-rich surface projections called filopodia.
19166	
19167	
19168	
19169	
19170	this protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.
19171	
19172	
19173	
19174	
19175	
19176	
19177	may be involved in transcriptional regulation.
19178	
19179	
19180	may play a role in a signaling pathway regulating nuclear functions of cell proliferaration. phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
19181	
19182	
19183	
19184	
19185	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
19186	
19187	involved in the presentation of foreign antigens to the immune system.
19188	
19189	plays an important role in the organization of the cytoskeleton. binds to and sequesters actin monomers (g actin) and therefore inhibits actin polymerization (by similarity).
19190	plays an important role in the organization of the cytoskeleton. binds to and sequesters actin monomers (g actin) and therefore inhibits actin polymerization (by similarity).
19191	could be involved in the control of plant growth and development. phosphorylates two ribosomal proteins, p14 and p16.
19192	
19193	plays an important role in the elongation step of protein synthesis.
19194	
19195	
19196	may facilitate pttg1 nuclear translocation.
19197	
19198	
19199	
19200	
19201	
19202	
19203	
19204	
19205	
19206	
19207	
19208	potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. the effects of betacellulin are probably mediated by the egf receptor and other related receptors.
19209	
19210	
19211	
19212	
19213	
19214	probable collagen protein.
19215	
19216	il-8 is a chemotactic factor that attracts neutrophils, basophils, and t-cells, but not monocytes. it is also involved in neutrophil activation. it is released from several cell types in response to an inflammatory stimulus. il-8(6-77) has a 5-10-fold higher activity on neutrophil activation, il-8(5-77) has increased activity on neutrophil activation and il-8(7-77) has a higher affinity to receptors cxcr1 and cxcr2 as compared to il-8(1-77), respectively.
19217	
19218	acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.
19219	
19220	
19221	
19222	
19223	
19224	functions as an e3-type small ubiquitin-like modifier (sumo) ligase, stabilizing the interaction between ube2i and the substrate, and as a sumo-tethering factor. plays a crucial role as a transcriptional coregulation in various cellular pathways, including the stat pathway, the p53 pathway and the steroid hormone signaling pathway. the effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
19225	
19226	
19227	catalyzes the formation of s-adenosylmethionine from methionine and atp.
19228	
19229	
19230	
19231	
19232	
19233	
19234	
19235	
19236	
19237	
19238	
19239	
19240	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
19241	
19242	
19243	
19244	
19245	
19246	
19247	
19248	
19249	
19250	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
19251	
19252	
19253	
19254	
19255	
19256	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
19257	
19258	
19259	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
19260	
19261	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
19262	
19263	a49 is easily dissociated from the rest of pol a (pol i), producing the form a*, which shows impaired transcriptional activity and increased sensitivity to alpha-amanitin. the function of a49 might be linked to the rnase h activity that was found associated with this subunit.
19264	
19265	
19266	
19267	essential for cell viability. taf9 and taf9b are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. may have a role in gene regulation associated with apoptosis. tafs are components of the transcription factor iid (tfiid) complex, the tbp-free tafii complex (tftc), the pcaf histone acetylase complex and the staga transcription coactivator-hat complex. tfiid or tftc are essential for the regulation of rna polymerase ii-mediated transcription.
19268	
19269	
19270	
19271	
19272	
19273	
19274	
19275	
19276	involved in dna double strand break (dsb) repair.
19277	
19278	
19279	
19280	catalyzes the covalent attachment of ubiquitin to other proteins. mediates the selective degradation of short-lived and abnormal proteins. functions in the e6/e6-ap-induced ubiquitination of p53/tp53.
19281	
19282	
19283	
19284	
19285	
19286	
19287	
19288	
19289	
19290	
19291	
19292	
19293	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
19294	
19295	
19296	
19297	
19298	
19299	
19300	this protein promotes the gtp-dependent binding of aminoacyl-trna to the a-site of ribosomes during protein biosynthesis.
19301	
19302	
19303	
19304	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
19305	
19306	
19307	
19308	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
19309	terminates the action of gaba by its high affinity sodium-dependent reuptake into presynaptic terminals (by similarity).
19310	
19311	
19312	has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (drf1). induces microspike formation, in vivo (by similarity). in vitro, stimulates n-wasp- induced arp2/3 complex activation in the absence of cdc42 (by similarity). may play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. implicated in regulation of actin polymerization and cell adhesion.
19313	
19314	
19315	
19316	
19317	
19318	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
19319	
19320	
19321	
19322	muscle contraction.
19323	
19324	
19325	
19326	lacks cytidine deaminase activity, at least on rna molecules (monomeric nucleoside substrates or synthetic apob rna template). unable to reduce hiv-1 infectivity in vitro.
19327	
19328	involved in the replication of mitochondrial dna.
19329	
19330	
19331	
19332	
19333	
19334	
19335	
19336	
19337	
19338	
19339	
19340	involved in calcium binding and microtubule stabilization.
19341	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
19342	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. this is a component of the iron-sulfur (ip) fragment of the enzyme.
19343	
19344	
19345	
19346	
19347	
19348	
19349	
19350	
19351	
19352	cell surface proteoglycan that bears heparan sulfate. putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (by similarity).
19353	
19354	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
19355	
19356	
19357	
19358	
19359	
19360	binds preferentially single-stranded dna and unwinds double stranded dna.
19361	
19362	
19363	this protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate (by similarity).
19364	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
19365	may be involved in transcriptional regulation.
19366	
19367	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
19368	
19369	this is the heme a-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
19370	
19371	
19372	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
19373	
19374	
19375	regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. forms complexes with beta-catenin and gamma-catenin/plakoglobin. beta-catenin may be a substrate for the catalytic activity of ptp- kappa.
19376	
19377	
19378	
19379	
19380	
19381	
19382	binds to wnt proteins and inhibits their activities. may be involved in mesoderm segmentation.
19383	
19384	
19385	
19386	dna-binding protein that specifically binds heat shock promoter elements (hse) and activates transcription. in higher eukaryotes, hsf is unable to bind to the hse unless the cells are heat shocked.
19387	hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin a.
19388	
19389	
19390	
19391	
