Row	SPFunction
1	
2	
3	may bind rna.
4	
5	
6	
7	
8	
9	
10	forms hydroxylysine residues in -xaa-lys-gly- sequences in collagens. these hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen crosslinks.
11	ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached.
12	negative regulator of the heat shock response. negatively affects hsf1 dna-binding activity. may have a role in the suppression of the activation of the stress response during the aging process.
13	
14	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
15	
16	
17	nmda receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine.
18	
19	major role in the synthesis of nucleoside triphosphates other than atp (by similarity).
20	
21	
22	component of the origin recognition complex (orc) that binds origins of replication. it has a role in both chromosomal replication and mating type transcriptional silencing. binds to the ars consensus sequence (acs) of origins of replication in an atp-dependent manner.
23	could be involved in microtubule organization.
24	
25	the elongin bc complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different e3 ubiquitin ligase complexes, including the von hippel-lindau ubiquitination complex cbc(vhl). by binding to bc- box motifs it seems to link target recruitment subunits, like vhl and members of the socs box family, to cullin/rbx1 modules that activate e2 ubiquitination enzymes.
26	netrins control guidance of cns commissural axons and peripheral motor axons (by similarity).
27	
28	
29	
30	
31	
32	heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
33	
34	involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. plays a role in the assembly of the exocyst.
35	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
36	
37	
38	
39	
40	may be involved in transcriptional regulation.
41	neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. potent inhibitor of angiogenesis. as it does not undergo the s (stressed) to r (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
42	may act as an helicase that plays a role in rna metabolism in multiple tissues and organs within the developing embryo.
43	
44	might be involved in growth regulation, and in myelinization in the peripheral nervous system.
45	
46	
47	
48	
49	carries out a dual function: signal transduction and activation of transcription. binds to the gas element and activates prl-induced transcription.
50	
51	does not act as an allosteric activator of the cholera toxin catalytic subunit. component of a regulated secretory pathway involved in ca(2+)-dependent release of acetylcholine.
52	
53	
54	polycomb group (pcg) protein. pcg proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. pcg proteins are not required to initiate repression, but to maintain it during later stages of development. they probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. component of the prc2 complex, which methylates lys-9 and lys-27 residues of histone h3.
55	
56	gtpase-activating protein for the adp ribosylation factor family. may serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting pak1 to adhesions and the leading edge of lamellipodia. sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes.
57	may play a positive role in ahr-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
58	may play a positive role in ahr-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
59	
60	
61	
62	
63	
64	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
65	
66	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
67	
68	
69	the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the er, via the golgi up to the trans golgi network. coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-er transport of dilysine-tagged proteins. the zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (by similarity).
70	processively dephosphorylates ser-2 and ser-5 of the heptad repeats ysptsps in the c-terminal domain of the largest rna polymerase ii subunit. this promotes the activity of rna polymerase ii.
71	
72	grp stimulates gastrin release as well as other gastrointestinal hormones.
73	
74	
75	
76	
77	soluble frizzled-related proteins (sfrps) function as modulators of wnt signaling through direct interaction with wnts. they have a role in regulating cell growth and differentiation in specific cell types. sfrp1 decreases intracellular beta-catenin levels (by similarity). has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. in vascular cell cycle, delays the g1 phase and entry into the s phase (by similarity). in kidney development, inhibits tubule formation and bud growth in metanephroi (by similarity). inhibits wnt1/wnt4-mediated tcf-dependent transcription.
78	
79	
80	
81	may be involved in transcriptional regulation.
82	may be involved in transcriptional regulation.
83	soluble frizzled-related proteins (sfrps) function as modulators of wnt signaling through direct interaction with wnts. they have a role in regulating cell growth and differentiation in specific cell types. sfrp1 decreases intracellular beta-catenin levels (by similarity). has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. in vascular cell cycle, delays the g1 phase and entry into the s phase (by similarity). in kidney development, inhibits tubule formation and bud growth in metanephroi (by similarity). inhibits wnt1/wnt4-mediated tcf-dependent transcription.
84	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
85	may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (by similarity).
86	
87	
88	may be involved in transcriptional regulation.
89	
90	cysteine protease cleaving the c-terminal amino acid of atg8 to reveal a c-terminal glycine. atg8 ubiquitin-like activity requires the exposure of the glycine at the c-terminus for its conjugation to phosphatidylethanolamine and its insertion to membranes, which is necessary for autophagy. inhibited by n- ethylmaleimide.
91	
92	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
93	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
94	
95	
96	
97	derived from proteolytic degradation of complement c3, c3a anaphylatoxin is a mediator of local inflammatory process. it induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
98	
99	may mediate activation of casp1 via asc and promote activation of nf-kappa-b via ikk.
100	may be involved in transcriptional regulation.
101	appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. phosphorylation of dmd or utrn may modulate their affinities for associated proteins (by similarity).
102	suggested to be involved in kindling epileptogenesis and hippocampal plasticity. has a strong proteolytic activity against fibronectin (by similarity).
103	this protein mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
104	
105	catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. may also function as a transporter of branched chain alpha-keto acids.
106	
107	stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter slc2a1/glut1, but not slc2a4/glut4, expression.
108	may be involved in transcriptional regulation.
109	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
110	receptor on natural killer (nk) cells for hla-c alleles. does not inhibit the activity of nk cells.
111	
112	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein.
113	implicated in the suppression of cell death. interacts with the bcl-2 and adenovirus e1b 19 kda proteins (by similarity).
114	may have both lysophospholipase and carbohydrate-binding activities.
115	
116	required for the transport of mannose 6-phosphate receptors (mpr) from endosomes to the trans-golgi network.
117	subunit of the splicing factor sf3a required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex.
118	
119	
120	mediates iodide uptake in the thyroid gland.
121	
122	plays an essential role in cell growth and maintenance of cell morphology.
123	
124	oxidizes the coa esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids.
125	
126	fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly.
127	
128	
129	plays a role in the formation of functional neural circuits from the early stages of synapse formation. has a role in the development of cns functions involved in locomotor activity.
130	lacks adp-ribosylation enhancing activity (by similarity).
131	
132	probable regulatory protein involved in regulating the response to growth factors.
133	calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction.
134	binds gram-positive and gram-negative bacteria.
135	
136	
137	
138	major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
139	plays a role in hyaluronan/hyaluronic acid (ha) synthesis.
140	sperm surface antigen involved in some step of early cleavage of the fertilized oocyte.
141	
142	probable rna-binding protein, which may be required during spermatogenesis. may act by binding to the 3@#$%&utr of mrnas and regulating their translation (by similarity).
143	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
144	facilitative glucose transporter. probably a neuronal glucose transporter.
145	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule important in cns development. is likely to signal over only few cell diameters.
146	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule important in cns development. is likely to signal over only few cell diameters.
147	part of a complex implicated in the control of actin polymerization in cells.
148	
149	
150	
151	serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as tnf-alpha. appears to act upstream of the jun n-terminal pathway.
152	restores repair of base-base and single- nucleotide insertion-deletion mismatches, and increases the proficiency to process heteroduplexes with two-, three-, or four- nucleotide insertion-deletion mismatches. gtbp binds covalently to g/t mismatches.
153	associated with snrnp u1, u2, u4/u6 and u5.
154	
155	
156	
157	receptor for lutropin-choriogonadotropic hormone. the activity of this receptor is mediated by g proteins which activate adenylate cyclase.
158	
159	
160	
161	catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. participates in biosynthesis of hnk-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. may be indirectly involved in synapse plasticity of the hippocampus, via its role in hnk-1 biosynthesis.
162	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
163	
164	molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin (by similarity).
165	
166	molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
167	
168	may play a role in growth and differentiation of tissues involved in metabolic control. may play a regulatory role during g0/g1 transition of cell growth.
169	promotes adhesion of endothelial cells through interaction of integrins and the rgd motif. could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling.
170	involved in postreplication mismatch repair. binds specifically to dna containing mismatched nucleotides thereby marking the region to be excised.
171	possibly involved in t-cell activation. binds to b7-1 (cd80) and b7-2 (cd86).
172	
173	transports pantothenate, biotin and lipoate in the presence of sodium.
174	
175	fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
176	
177	
178	
179	
180	may play an important role in modulating bone turnover. promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. in addition, inhibits osteocalcin production.
181	major component of the extracellular matrix of cartilage.
182	
183	
184	has antibacterial activity (potential).
185	inhibits snare complex formation by absorbing free syntaxin-1.
186	
187	
188	
189	
190	seems to be involved in n-acetylation (by similarity).
191	
192	
193	catalyzes the removal of elemental sulfur from cysteine to produce alanine. it supplies the inorganic sulfur for iron- sulfur (fe-s) clusters.
194	responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase a). it catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
195	molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
196	inositol 5-phosphatase which has a role in clathrin- mediated endocytosis.
197	
198	component of the elastin-associated microfibrils.
199	
200	
201	
202	
203	
204	
205	acts on phosphatidylinositol (pi) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. stt4 functions in pkc1 protein kinase pathway.
206	protein transport. probably involved in vesicular traffic (by similarity).
207	crystallins are the dominant structural components of the vertebrate eye lens.
208	
209	
210	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
211	may be involved in intracellular trafficking. probable association with membranes.
212	interacts with the beta subunit of protein kinase ckii and stimulates phosphorylation of dna topoisomerase ii alpha by ckii.
213	
214	
215	
216	
217	
218	
219	
220	degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules.
221	
222	
223	involved in complement regulation. can associate with lipoproteins and may play a role in lipid metabolism.
224	possesses significant protein thiol-disulfide oxidase activity.
225	
226	
227	
228	
229	
230	
231	probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as notch receptors and app (beta-amyloid precursor protein). requires the other members of the gamma-secretase complex to have a protease activity. may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. may function in the cytoplasmic partitioning of proteins.
232	could regulate export of the bud site and axial growth sites selection protein axl2 and possibly other secretory proteins from the endoplasmic reticulum in copii-coated vesicles. seems to be required for axial budding pattern in haploid cells.
233	
234	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. preferentially binds to g(o)-alpha and g(i)-alpha-3 (by similarity).
235	
236	
237	
238	pa2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. this isozyme hydrolyzes more efficiently l-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than l-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, l- alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or l- alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. may be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.
239	
240	this enzyme metabolizes arachidonic acid predominantly via a nadph-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. one of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.
241	binds gtp, gdp and gmp.
242	inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. inhibits degradation of mdm2. can reverse mdm2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions.
243	
244	cell surface adhesion protein. mediate the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes.
245	orphan receptor.
246	
247	
248	involved in the maturation of asn-linked oligosaccharides. progressively trim alpha-1,2-linked mannose residues from man(9)glcnac(2) to produce man(5)glcnac(2).
249	involved in the maturation of asn-linked oligosaccharides. trim alpha-1,2-linked mannose residues from man(9)glcnac(2) to produce first man(8)glcnac(2) then man(6)glcnac and a small amount of man(5)glcnac.
250	may act as a low affinity receptor for acetylcholine.
251	
252	required for the processing of the 27s pre-rrna (by similarity).
253	
254	
255	
256	
257	
258	
259	
260	binds to oocyte zona pellucida in vivo. may play a role in the fertilization process and/or early embryonic development.
261	binds to the fc region of immunoglobulins epsilon. high affinity receptor. responsible for initiating the allergic response. binding of allergen to receptor-bound ige leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. the same receptor also induces the secretion of important lymphokines.
262	
263	acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. one of the activated genes is an inhibitor of cyclin-dependent kinases. apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of bcl-2 expression.
264	associates with cd4 or cd8 and delivers costimulatory signals for the tcr/cd3 pathway.
265	receptor for the fc region of complexed immunoglobulins gamma. low affinity receptor.
266	
267	
268	
269	associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mrna splicing (by similarity).
270	
271	may play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. maybe involved in microtubule formation and/or stabilization. may play a key role during tumor development and progression.
272	
273	e2-like enzyme which forms an intermediate with ufm1 via a thioester linkage.
274	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
275	responsible for the synthesis of complex-type n-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
276	
277	
278	
279	can reduce the dialdehyde protein-binding form of aflatoxin b1 (afb1) to the nonbinding afb1 dialcohol. may be involved in protection of liver against the toxic and carcinogenic effects of afb1, a potent hepatocarcinogen (by similarity).
280	catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. has little activity towards prostaglandins a1 and e1.
281	
282	
283	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
284	
285	
286	
287	
288	
289	
290	
291	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
292	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb (by similarity).
293	
294	transcriptional repressor.
295	
296	
297	
298	
299	
300	putative atp-dependent protease.
301	
302	may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes (by similarity).
303	
304	probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. likely to be involved in key signaling pathways crucial for normal limb development. may participate in wnt signaling.
305	
306	
307	involved in the cellular defense against the biological effects of o6-methylguanine (o6-meg) in dna. repairs alkylated guanine in dna by stoichiometrically transferring the alkyl group at the o-6 position to a cysteine residue in the enzyme. this is a suicide reaction: the enzyme is irreversibly inactivated.
308	catalyzes the phosphorylation of phosphatidylinositol-4- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol-4,5-biphosphate.
309	
310	straight-chain enoyl-coa thioesters from c4 up to at least c16 are processed, although with decreasing catalytic rate.
311	
312	
313	
314	
315	
316	
317	atp-dependent rna helicase which is a subunit of the eif4f complex involved in cap recognition and is required for mrna binding to ribosome. in the current model of translation initiation, eif4a unwinds rna secondary structures in the 5@#$%& untranslated region of mrnas which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
318	
319	
320	bifunctional enzyme with both atp sulfurylase and aps kinase activity, which mediates two steps in the sulfate activation pathway. the first step is the transfer of a sulfate group to atp to yield adenosine 5@#$%&-phosphosulfate (aps), and the second step is the transfer of a phosphate group from atp to aps yielding 3@#$%&-phosphoadenylylsulfate (paps: activated sulfate donor used by sulfotransferase). in mammals, paps is the sole source of sulfate; aps appears to be only an intermediate in the sulfate- activation pathway. may have a important role in skeletogenesis during postnatal growth (by similarity).
321	
322	
323	
324	
325	
326	regulates leading edge dynamics and cell motility in fibroblasts. may be involved in cytokinesis and signal transduction (by similarity).
327	
328	interacts with the human immunodeficiency virus tat transactivator. specifically suppresses tat-mediated transactivation. probably involved in atp hydrolysis. it is possible that proteins mss1 and tbp-1 compete with each other to regulate the interaction with the transcriptional complex with the hiv gene, thereby influencing gene expression in both directions.
329	
330	may act as a dnase and a rnase (potential).
331	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. this is a component of the iron-sulfur (ip) fragment of the enzyme.
332	type i collagen is a member of group i collagen (fibrillar forming collagen).
333	
334	subunit of the splicing factor sf3a required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex.
335	p65 is a subunit of the nuclear factor kappa-b, a second messenger, which activates the transcription of a number of genes in multiple tissues. the inhibitory effect of i-kappa-b upon nf- kappa-b in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak dna-binding site which could contribute directly to dna binding in the nf-kappa-b complex.
336	scaffold protein which probably links toll-like receptors (tlrs) to basic cellular processes via its interaction with the complex containing irak kinases and traf6. can activate ap1/jun and elk1. not required for nf-kappa-b activation. probably involved in innate immune response.
337	mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. less sensitive than slc29a1 to inhibition by nitrobenzylthioinosine (nbmpr), dipyridamole, dilazep and draflazine.
338	component of the n-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an asn-x-ser/thr consensus motif in nascent polypeptide chains. n-glycosylation occurrs cotranslational and the complex associates with the sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (er). sst3a seems to be involved in complex substrate specificity (by similarity).
339	
340	
341	augments natural killer cell activity in spleen cells and stimulates interferon gamma production in t-helper type i cells.
342	probable transcription factor. may play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues.
343	intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.
344	the muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of g proteins. primary transducing effect is inhibition of adenylate cyclase.
345	one of the major non-collagenous components of the tectorial membrane (by similarity). the tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
346	
347	
348	appears to play a role in the switch from cap-dependent to ires-mediated translation during mitosis, apoptosis and viral infection. cleaved by some caspases and viral proteases.
349	binds to and inhibits the transcriptional repressor zbtb33, which may lead to activation of target genes of the wnt signaling pathway (by similarity). may associate with and regulate the cell adhesion properties of both c- and e-cadherins. implicated both in cell transformation by src and in ligand- induced receptor signaling through the egf, pdgf, csf-1 and erbb2 receptors.
350	
351	may be involved in signal transduction as a component of a multimeric receptor complex.
352	forms calcium-sensitive chloride channels. may conduct other physiologically significant anions such as bicarbonate.
353	may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. it is essential for disk morphogenesis.
354	
355	
356	catalyzes the conversion of pgh2 to pgd2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation.
357	receptor-proximal protein kinase regulating integrin- mediated signal transduction. may act as a mediator of inside-out integrin signaling. focal adhesion protein part of the complex ilk-pinch. this complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also akt1 and gsk3b.
358	as-c proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
359	occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
360	
361	can stimulate e2f-dependent transcription. binds dna cooperatively with e2f family members through the e2 recognition site, 5@#$%&-tttc[cg]cgc-3@#$%&, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the dp2/e2f complex functions in the control of cell-cycle progression from g1 to s phase. the e2f-1/dp complex appears to mediate both cell proliferation and apoptosis.
362	single stranded dna-dependent atp-dependent helicase. has a role in chromosome translocation. the dna helicase ii complex binds preferentially to fork-like ends of double-stranded dna in a cell cycle-dependent manner. it works in the 3@#$%&-5@#$%& direction. binding to dna may be mediated by p70. involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination. the ku p70/p86 dimer acts as regulatory subunit of the dna-dependent protein kinase complex dna-pk by increasing the affinity of the catalytic subunit prkdc to dna by 100-fold. the ku p70/p86 dimer is probably involved in stabilizing broken dna ends and bringing them together. the assembly of the dna-pk complex to dna ends is required for the nhej ligation step. required for osteocalcin gene expression (by similarity).
363	may act as a modulator of the olfactory signal- transduction cascade.
364	may play an important role in lipogenesis.
365	
366	may regulate the transcription of specific genes during normal development. may play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. implicated in the transduction of shh signal (by similarity).
367	transcriptional repressor; binds to the dna sequence 5@#$%&- ccggaagt-3@#$%&.
368	may be involved in transcriptional regulation.
369	catalyzes the exchange of eukaryotic initiation factor 2-bound gdp for gtp.
370	molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
371	may be an activator of the jnk/sapk pathway. phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
372	protease that regulate the availability of igfs by cleaving igf-binding proteins.
373	
374	acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
375	plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mglurs) at synapses (by similarity).
376	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
377	orphan receptor. could be a chemotactic peptide receptor. may have a function in bone metabolism. acts as a coreceptor for several siv strains (sivmac316, sivmac239, sivmacl7e-fr and sivsm62a), as well as a primary hiv-1 strain (92ug024-2).
378	orphan receptor. could be a chemotactic peptide receptor. may have a function in bone metabolism. acts as a coreceptor for several siv strains (sivmac316, sivmac239, sivmacl7e-fr and sivsm62a), as well as a primary hiv-1 strain (92ug024-2).
379	
380	receptor that may play a role in the perception of bitterness and is gustducin-linked. may play a role in sensing the chemical composition of the gastrointestinal content. the activity of this receptor may stimulate alpha gustducin, mediate plc-beta-2 activation and lead to the gating of trpm5 (by similarity).
381	may play a role in the regulation of pre-mrna processing.
382	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
383	
384	involved in the targeting and/or fusion of transport vesicles to their target membrane.
385	important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex gpib-ix-v. also acts as a chaperone for coagulation factor viii, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
386	involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. the multiple transmembrane domains and lumenal hydrophilic domains of the cholinephosphotransferase might participate in the transport process.
387	
388	
389	may be a regulatory site in cholesterol biosynthetic pathway.
390	
391	
392	
393	
394	
395	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters. binds to the tax-responsive element (tre) of htlv-i. mediates pka-induced stimulation of cre-reporter genes.
396	
397	
398	can transform nih 3t3 cells. exhibits strong mitogenic and angiogenic properties.
399	
400	
401	
402	
403	
404	may have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
405	
406	
407	
408	thought to form a receptor-activated non-selective calcium permeant cation channel. probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or g-protein coupled receptors. has also been shown to be calcium-selective (by similarity). may also be activated by intracellular calcium store depletion.
409	collagen type iv is specific for basement membranes.
410	
411	
412	responsible for the deiodination of t4 (3,5,3@#$%&,5@#$%&- tetraiodothyronine) into rt3 (3,3@#$%&,5@#$%&-triiodothyronine) and of t3 (3,5,3@#$%&-triiodothyronine) into t2 (3,3@#$%&-diiodothyronine). rt3 and t2 are inactive metabolites. may play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. can regulate circulating fetal thyroid hormone concentrations throughout gestation. essential role for regulation of thyroid hormone inactivation during embryological development.
413	type i collagen is a member of group i collagen (fibrillar forming collagen).
414	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein.
415	polymerase that creates the 3@#$%& poly(a) tail of mrna@#$%&s. also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. may acquire specificity through interaction with a cleavage and polyadenylation specificity factor (cpsf) at its c-terminus.
416	contrapsin inhibits trypsin-like proteases.
417	
418	inhibits nf-kappa-b by complexing with and trapping it in the cytoplasm. may be involved in regulation of transcriptional responses to nf-kappa-b, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. controlled by sequential serine-phosphorylation, ubiquitination and degradation. tyrosine-phosphorylation could only lead to dissociation from nf-kappa-b.
419	this is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.
420	putative notch ligand involved in the mediation of notch signaling. involved in limb development (by similarity).
421	
422	
423	
424	
425	exhibits a potent rnase activity. has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nm) against a vancomycin resistant enterococcus faecium.
426	may be involved in eye development.
427	
428	required for protein transport from the er to the golgi complex.
429	inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the e1 alpha subunit, thus contributing to the regulation of glucose metabolism.
430	
431	
432	
433	probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as notch receptors and app (beta-amyloid precursor protein). requires the other members of the gamma-secretase complex to have a protease activity. may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. stimulates cell-cell adhesion though its association with the e-cadherin/catenin complex. under conditions of apoptosis or calcium influx, cleaves e-cadherin promoting the disassembly of the e-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating wnt signaling. may also play a role in hematopoiesis.
434	nuclear phosphoprotein which forms a tight but non- covalently linked complex with the jun/ap-1 transcription factor. in the heterodimer, c-fos and jun/ap-1 basic regions each seems to interact with symmetrical dna half sites. has a critical function in regulating the development of cells destined to form and maintain the skeleton. it is thought to have an important role in signal transduction, cell proliferation and differentiation.
435	bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. has also low glutathione peroxidase activity with t- butyl and cumene hydroperoxides. is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.
436	
437	
438	binds the ligand binding domain of the thyroid receptor (thrb) in the presence of triiodothyronine and enhances thrb- modulated transcription. golgi auto-antigen; probably involved in maintaining cis-golgi structure.
439	mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.
440	transcription factor capable of interacting with purine rich repeats (ga repeats). necessary for the expression of the adenovirus e4 gene.
441	
442	
443	forms a channel with a broad specificity. mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, na(+), k(+), cl(-), and deprotonated monocarboxylates are excluded. also permeable to urea but not to glycerol.
444	required for protein transport from the er to the golgi complex.
445	may play an imortant role in the nervous system and in modulating immune function.
446	
447	
448	growth suppressor that facilitates the entry of the cell into cell cycle arrest. functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as sv40 large t antigen, adenovirus e1a, and the transcription factor e2f. necdin also interacts with p53 and works in an additive manner to inhibit cell growth. functions also as transcription factor and binds directly to specific guanosine-rich dna sequences (by similarity).
449	
450	
451	
452	
453	binds to, and destabilizes, ornithine decarboxylase. does not accelerate ornithine decarboxylase degeneration (by similarity).
454	
455	
456	
457	binds to iron-responsive elements (ires), which are stem-loop structures found in the 5@#$%&utr of ferritin, and delta aminolevulinic acid synthase mrnas, and in the 3@#$%&utr of transferrin receptor mrna. binding to the ire element in ferritin results in the repression of its mrna translation. binding of the protein to the transferrin receptor mrna inhibits the degradation of this otherwise rapidly degraded mrna.
458	may methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
459	putative dna helicase component of the ino80 complex which remodels chromatin by shifting nucleosomes. its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates. the ino80 complex is involved in dna repair by associating to ser-129 phosphorylated h2a histones as a response to dna damage.
460	
461	
462	
463	
464	
465	
466	
467	
468	required only in the female germ line. it is important for oocyte formation and in the specification of the posterior structures of the embryo.
469	reversible hydration of carbon dioxide.
470	
471	
472	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. it is a crucial enzyme in transmembrane signaling.
473	
474	
475	
476	
477	
478	
479	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
480	may be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. in mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
481	catalyzes the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. is also responsible for the sulfation and activation of minoxidil. mediates the metabolic activation of carcinogenic n-hydroxyarylamines to dna binding products and could so participate as modulating factor of cancer risk.
482	e3 ubiquitin ligase protein that is required for specification of r7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of tramtrack (ttk). e3 ubiquitin ligases accept ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cells in the eye, leading to the differentiation of cells into neurons. also involved in external sensory organ development.
483	
484	
485	
486	
487	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
488	chaperone. isoform 2 may function as an endogenous inhibitory regulator of hsc70 by competing the cochaperones.
489	
490	required for protein transport from the er to the golgi complex.
491	
492	
493	component of the cornified envelope of keratinocytes. may link the cornified envelope to desmosomes and intermediate filaments. may act as a localization signal in pkb/akt-mediated signaling.
494	
495	
496	septins are gtpases involved in cytokinesis that assemble into filaments and form a ring at the cleavage site. may act by recruiting myo1 and hof1, a protein involved in septation, to the site of cleavage. septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
497	may be involved in several stages of intracellular trafficking (by similarity).
498	
499	
500	
501	
502	muscle assembly regulating factor. mediates the antiparallel assembly of titin (ttn) molecules at the sarcomeric z-disk.
503	involved in negative regulation of cell growth. may have tumor suppressor properties. may play a negative regulatory role in the ras-mapk pathway (by similarity). may function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. could specifically be involved in phospholipid signal transduction.
504	it participates in a very early step in initiation. rp-a is a single-stranded dna-binding protein. absolutely required for simian virus 40 dna replication in vitro.
505	
506	the kinesin family may recognize, transport and position their specific cargos in a single type of neuronal cell.
507	
508	seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. may be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. the calcium-bound recoverin prolongs the photoresponse.
509	
510	binds medium- and long-chain acyl-coa esters with very high affinity and may function as an intracellular carrier of acyl-coa esters (by similarity).
511	role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation (by similarity).
512	
513	transcription factor that binds to the interleukin-6 (il-6)-responsive elements identified in the promoters of various acute-phase protein genes.
514	associates specifically with huntingtin. this binding is enhanced by an expanded polyglutamine repeat.
515	protein transport. probably involved in vesicular traffic (by similarity).
516	protein transport. probably involved in vesicular traffic (by similarity).
517	
518	inhibits ipf1/pdx1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (by similarity). in complex with cul3, involved in ubiquitination of both pcgf4 and h2afy.
519	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
520	
521	
522	may be involved in cytokinesis, motility, and signal transduction (by similarity).
523	gtpase-activating protein for the adp ribosylation factor family (potential).
524	able to form cytoplasmic structures termed death effector filaments. enhances apaf1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. seems to bind atp.
525	motor required for the retrograde transport of golgi vesicles to the endoplasmic reticulum. has a microtubule plus end- directed motility.
526	adds a myristoyl group to the n-terminal glycine residue of certain cellular and viral proteins.
527	pair-rule protein that regulates embryonic segmentation and adult bristle patterning. transcriptional repressor of genes that require a bhlh protein for their transcription (e.g. the fushi tarazu gene).
528	complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. known to act on mmp-1, mmp-2, mmp-3, mmp-7, mmp-8, mmp-9, mmp-10, mmp-13, mmp-14, mmp-15, mmp-16 and mmp-19.
529	this multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. at the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. may therefore cause structural modifications of exofacial proteins. inside the cell, seems to form/rearrange disulfide bonds of nacent proteins. at high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. at low concentrations, facilitates aggregation (antichaperone activity). may be involved with other chaperones in the structural modification of the tg precursor in hormone biogenesis. also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein mttp.
530	
531	this protein participates in processes of transmission and amplification of the visual signal. necessary for the formation of a functional phosphodiesterase holoenzyme.
532	
533	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
534	
535	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
536	
537	
538	
539	may be an ion-channel regulator. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis. involved in adhesive protein-protein and protein-carbohydrate interactions.
540	may play a role in vesicular transport from endoplasmic reticulum to golgi.
541	forms a water-specific channel. osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
542	involved in the intracellular trafficking of cholesterol. may play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals.
543	may be involved in targeting uroplakins to urothelial apical membranes (by similarity).
544	
545	
546	the electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- coa dehydrogenases, glutaryl-coa and sarcosine dehydrogenase. it transfers the electrons to the main mitochondrial respiratory chain via etf-ubiquinone oxidoreductase (etf dehydrogenase).
547	
548	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
549	structure-specific dna repair endonuclease responsible for the 5-prime incision during dna repair.
550	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
551	may be involved in transcriptional regulation.
552	associated to surface igm-receptor; may be involved in signal transduction.
553	receptor for the lysosphingolipid sphingosine 1- phosphate (s1p). s1p is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. is coupled to both the g(i/0)alpha and g(12) subclass of heteromeric g-proteins (by similarity). may play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
554	receptor for the lysosphingolipid sphingosine 1- phosphate (s1p). s1p is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. is coupled to both the g(i/0)alpha and g(12) subclass of heteromeric g-proteins (by similarity). may play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
555	may be involved in transcriptional regulation.
556	
557	
558	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i (by similarity).
559	
560	v-snare that mediates vesicle transport pathways through interactions with t-snares on the target membrane. these interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. may participate in protein trafficking in the secretory pathway.
561	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
562	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
563	has a tumor-suppressor role for nes1 in breast and prostate cancer.
564	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
565	
566	creates a soluble precursor oligosaccharide fuc-alpha ((1,2)galbeta-) called the h antigen which is an essential substrate for the final step in the soluble a and b antigen synthesis pathway. h and se enzymes fucosylate the same acceptor substrates but exhibit different km values.
567	creates a soluble precursor oligosaccharide fuc-alpha ((1,2)galbeta-) called the h antigen which is an essential substrate for the final step in the soluble a and b antigen synthesis pathway. h and se enzymes fucosylate the same acceptor substrates but exhibit different km values.
568	
569	catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. sulfates hydroxysteroids like dhea. isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.
570	
571	
572	cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (nk) cells to mediate tumor cell lysis.
573	
574	could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. pro-apoptotic protein that functions intracellularly upstream of jnk activation and cytochrome c release.
575	
576	transcriptional activator. binds to fat body-specific enhancers of alcohol dehydrogenase (adh) and yolk protein genes. bbf-2 may play a role in fat body gene expression. it binds the consensus sequence 5@#$%&-t[ac]nacgtan[tg]c-3@#$%&.
577	
578	
579	part of the ap-3 complex, an adaptor-related complex which is not clathrin-associated. the complex is associated with the golgi region as well as more peripheral structures. it facilitates the budding of vesicles from the golgi membrane and may be directly involved in trafficking to lysosomes.
580	
581	sequence-specific rna-binding protein that regulates translation and mrna stability by binding the 3@#$%& untranslated regions (utrs) of mrna targets. may be required to support proliferation and self-renewal of stem cells (by similarity).
582	may modulate processing of the beta-amyloid precursor protein (app) and hence formation of beta-app.
583	
584	
585	induces a hyperpolarization-activated chloride current when expressed in xenopus oocytes. may have a functional role in muscle contraction.
586	essental for release from glucose repression. it interacts and has functional relationship to the regulatory protein snf4. interacts also with sip1, sip2 and gal83. could phosphorylates cat8.
587	connects the two cox monomers into the physiological dimeric form (by similarity).
588	
589	may be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides (by similarity).
590	catalyzes the conversion of phosphatidic acid (pa) to diacylglycerol (dg). in addition it hydrolyzes lysophosphatidic acid (lpa), ceramide-1-phosphate (c-1-p) and sphingosine-1- phosphate (s-1-p). the relative catalytic efficiency is pa > c-1-p > lpa > s-1-p.
591	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
592	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
593	
594	
595	cochaperone that binds directly to hsc70 and hsp70 and regulates their atpase activity.
596	
597	
598	involved in cytokinesis (potential).
599	
600	gtpase-activating protein for the adp ribosylation factor family (by similarity).
601	
602	
603	
604	
605	
606	receptor for members of the ephrin-a family. binds to ephrin-a1, -a4 and -a5. binds more poorly to ephrin-a2 and -a3. may play a role in a signal transduction process involved in hindbrain pattern formation.
607	protein kinase that act on both serine and threonine residues.
608	
609	
610	might act as an inhibitor of spontaneous calcium carbonate precipitation.
611	
612	beta-1,3-galactosyltransferase that transfers galactose from udp-galactose to substrates with a terminal beta-n- acetylglucosamine (beta-glcnac) residue. involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. inactive towards substrates with terminal alpha-n- acetylglucosamine (alpha-glcnac) or alpha-n-acetylgalactosamine (alpha-galnac) residues.
613	this is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
614	
615	regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. confers calcium sensitivity.
616	serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as tnf-alpha. appears to act upstream of the jun n-terminal pathway.
617	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
618	
619	cleaves the distal alpha 1,2-linked glucose residue from the glc(3)man(9)glcnac(2) oligosaccharide precursor in a highly specific manner.
620	
621	receptor for follicle-stimulating hormone. the activity of this receptor is mediated by g proteins which activate adenylate cyclase.
622	involved in the synthesis of the sugar donor dol-p-man which is required in the synthesis of n-linked and o-linked oligosaccharides and for that of gpi anchors. it is required for spore germination. has an essential role in cellular metabolism.
623	
624	participates in the innate immune response to microbial agents. cooperates with tlr2 and modulates the response to microbial constituents. acts via myd88 and traf6, leading to nf- kappa-b activation, cytokine secretion and the inflammatory response (by similarity).
625	
626	
627	
628	
629	
630	
631	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
632	
633	outward rectifying potassium channel.
634	
635	stimulates the kinase activity of stk38 and stk38l.
636	fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
637	
638	together with cas it may play a role in the control of epithelial cell polarity. seems to help to recruit protein tyrosine kinase 2 beta (ptk2b) to cell matrix adhesions, thereby initiating phosphorylation of ptk2b and ptk2b-dependent signaling (by similarity).
639	krueppel is a gap class segmentation protein. it is involved in the segmentation of the embryo and in the differentiation of the malpighian tubules.
640	essential subunit of n-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an asn-x-ser/thr consensus motif in nascent polypeptide chains.
641	
642	plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
643	soluble frizzled-related proteins (sfrps) function as modulators of wnt signaling through direct interaction with wnts. they have a role in regulating cell growth and differentiation in specific cell types. sfrp3/frzb appears to be involved in limb skeletogenesis. antagonist of wnt8 signaling. regulates chondrocyte maturation and long bone development.
644	probable potassium channel subunit. no channel activity observed in heterologous systems. may need to associate with another protein to form a functional channel.
645	cell surface proteoglycan that bears heparan sulfate.
646	important for bud site selection.
647	may be involved in transcriptional regulation.
648	
649	transcriptional activator which recognizes variations of the palindromic sequence 5@#$%&-attcccnngggaatt-3@#$%& (by similarity).
650	vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.
651	the physiological function of prp is not known.
652	
653	required for vesicular transport between the endoplasmic reticulum and the golgi apparatus (by similarity).
654	
655	
656	
657	
658	
659	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
660	
661	l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists. may be involved in the transmission of light information from the retina to the hypothalamus. this receptor binds domoate > kainate > l-glutamate = quisqualate > cnqx = dnqx > ampa > dihydrokainate > nmda.
662	
663	
664	
665	may facilitate pttg1 nuclear translocation.
666	molecular chaperone. has atpase activity (by similarity).
667	
668	involved in protein-protein interactions at adherens junctions.
669	
670	
671	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. has a sulfatase activity.
672	
673	
674	regulates cell cycle checkpoints and apoptosis in response to dna damage, particularly to dna double-strand breaks. inhibits cdc25c phosphatase by phosphorylation on ser-216, preventing the entry into mitosis. may also play a role in meiosis. regulates the tp53 tumor suppressor through phosphorylation at thr-18 and ser-20.
675	probably involved in a neuron-specific signal transduction.
676	
677	
678	component of the nadph-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from nadph to molecular oxygen, generating reactive oxidant intermediates. it may be important for the assembly and/or activation of the nadph-oxidase complex.
679	
680	
681	probable pseudophosphatase. lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. the pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts.
682	
683	
684	retains nfe2l2/nrf2 in the cytosol thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression (by similarity).
685	
686	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
687	
688	
689	
690	
691	may be involved in transcriptional regulation.
692	orphan receptor; its natural ligand is probably pregnane. binds to a response element in the cyp3a4 and abcb1/mdr1 genes promoter. activates its expression in response to a wide variety of endobiotics and xenobiotics.
693	
694	could be involved in cell-cell interactions.
695	neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release (by similarity).
696	functions as a component of the pcaf complex. the pcaf complex is capable of efficiently acetylating histones in a nucleosomal context. the pcaf complex could be considered as the human version of the yeast saga complex. also known as a coactivator for p53/tp53-dependent transcriptional activation.
697	receptor for ghrelin, coupled to g-alpha-11 proteins. stimulates growth hormone secretion. binds also other growth hormone releasing peptides (ghrp) (e.g. met-enkephalin and ghrp-6) as well as non-peptide, low molecular weight secretagogues (e.g. l-692,429, mk-0677, adenosine).
698	
699	
700	
701	
702	
703	receptor for the c-x-c chemokine cxcl16. used as a coreceptor by sivs and by strains of hiv-2 and m-tropic hiv-1.
704	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
705	seems to have a role in retrograde membrane traffic at the level of the golgi complex.
706	receptor involved in the costimulatory signal essential for t-lymphocyte proliferation and interleukin 2 production, by binding cd28 or ctla-4. may play a critical role in the early events of t-cell activation and costimulation of naive t-cells, such as deciding between immunity and anergy that is made by t- cells within 24 hours after activation. isoform 2 interferes with the formation of cd86 clusters, and thus acts as a negative regulator of t-cell activation.
707	
708	transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. binds to the consensus sequence 5@#$%&-agatag-3@#$%&.
709	transcriptional regulator. isoform ii binds to the promoter region of s15 chorion gene, whereas isoform ii binds to cf2 promoter, thus having a probable autoregulatory role.
710	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. has angiogenic inhibitor activity (by similarity). active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture (by similarity).
711	probable transcriptional regulator.
712	catalyzes the exchange of eukaryotic initiation factor 2-bound gdp for gtp.
713	
714	
715	binds differentially to the sh3 domains of certain proteins of signal transduction pathways. binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
716	may play a role in growth regulation and in negative regulation of cell cycle progesssion.
717	
718	can catalyze the production of ltc4 from lta4 and reduced glutathione. can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione.
719	
720	proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.
721	
722	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
723	
724	involved in neutrophil activation. in vitro, ena-78(8- 78) and ena-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.
725	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. preferentially uses palmitoleate, oleate and linoleate.
726	may assist ste12 in the pheromone-dependent expression of kar3 and cik1. also required for meiosis.
727	may be involved in the regulation of cellular proliferation and/or differentiation.
728	this is the receptor for stem cell factor (mast cell growth factor). it has a tyrosine-protein kinase activity. binding of the ligands leads to the autophosphorylation of kit and its association with substrates such as phosphatidylinositol 3-kinase (pi3k).
729	
730	this is a receptor for the tachykinin neuropeptide neuromedin k (neurokinin b). it is associated with g proteins that activate a phosphatidylinositol-calcium second messenger system.
731	
732	involved in ph regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. major proton extruding system driven by the inward sodium ion chemical gradient. plays an important role in signal transduction.
733	
734	
735	
736	cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (by similarity).
737	
738	acts as a transcriptional repressor. may play a role in limb-pattern formation. acts in cranofacial development and specifically in odontogenesis.
739	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. this isozyme is required for growth on lactate at high temperature.
740	
741	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
742	prevents motor-neuron apoptosis induced by a variety of signals.
743	
744	
745	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
746	binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh).
747	
748	protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation.
749	
750	
751	catalyzes the conjugation of leukotriene a4 with reduced glutathione to form leukotriene c4.
752	
753	plays a key role in the control of the eukaryotic cell cycle. component of the kinase complex that phosphorylates the repetitive c-terminus of rna polymerase ii.
754	
755	helicase; has atpase activity.
756	has an anti-hypocalcemic action on calcium and phosphate homeostasis.
757	may be involved in transcriptional regulation.
758	receptor for extracellular adenine nucleotides such as atp and adp. in pancreatic islets, may mediate some of the effects of extracellular atp on insulin secretion.
759	essential protein involved in the second catalytic step of pre-mrna splicing. involved in the selection of 3@#$%&l-type splice sites; this selection could be done via a 3@#$%& splice site-binding factor, prp16.
760	
761	dual specificity phosphatase that dephosphorylates map kinase erk2 on both thr-183 and tyr-185.
762	muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin- crosslinking protein. may be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the z-disks in muscle cells.
763	has a neutrophil chemotactic activity. also a positive regulator of chondrocyte proliferation.
764	functions in post-golgi recycling pathways. acts as a recycling carrier to the cell surface.
765	this protein is the receptor for csf-1, it is a protein tyrosine-kinase transmembrane receptor.
766	may play a role in organization and function of the active centromere-kinetochore complex.
767	
768	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
769	likely to be an important mediator of ventricular differentiation during cardiac development.
770	acts as probably catalytic component of the ccr4-not core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mrna deadenylase involved in mrna turnover. in vitro, pop2 has 3@#$%&- exoribonuclease activity with a preference for poly(a) rnas, but also degrades poly(u) and poly(c) rnas. is part of a glucose- sensing system involved in growth control in response to glucose availability.
771	
772	could be involved in the activation of both nf-kappa-b via a nf-kappa-b inhibitor kinase (ikk)-dependent mechanism and stress-activated protein kinase (sapk)/jnk.
773	
774	
775	may be required for progression through g1 and entry into s phase of cell growth. may play a regulatory role in pre- mrna splicing. autoregulates its own expression. plays a role in constitutive splicing and can modulate the selection of alternative splice sites (by similarity). could play an important role in development and differentiation in the spleen and thymus.
776	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. this isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-hne).
777	probable transcription activator for a number of lung- specific genes.
778	
779	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. this subunit is involved in antigen processing to generate class i binding peptides.
780	
781	srf is a transcription factor that binds to the serum response element (sre), a short sequence of dyad symmetry located 300 bp to the 5@#$%& of the site of transcription initiation of some genes (such as fos).
782	may be involved in follicular development. seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (gc) growth.
783	histone h3, along with histone h4, plays a central role in nucleosome formation.
784	
785	
786	
787	putative odorant receptor.
788	
789	involved in the presentation of foreign antigens to the immune system.
790	in cooperation with other chaperones, hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. these chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. they bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
791	unknown.
792	may be involved in transcriptional regulation.
793	involved in gm1/gd1b/ga1 ganglioside biosynthesis.
794	acts as a transcriptional repressor. binds to e-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes (by similarity).
795	may function as an androgen-independent transactivator of the prostate-specific antigen (psa) promoter. binds to 5@#$%&-ggat- 3@#$%& dna sequences. may play a role in the regulation of the prostate gland and/or prostate cancer development. acts as a transcriptional activator for serpinb5 promoter.
796	interacts with functionally mature hetero-oligomeric progesterone receptor complexes along with hsp90 and tebp.
797	
798	
799	hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
800	
801	may act as a gtpase activating protein for rab family protein(s) (potential).
802	
803	component of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends.
804	
805	
806	anchoring protein that mediates the subcellular compartmentation of protein kinase a (pka) and protein kinase c (pkc).
807	
808	
809	dna-binding protein that specifically binds heat shock promoter elements (hse) and activates transcription. in higher eukaryotes, hsf is unable to bind to the hse unless the cells are heat shocked.
810	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
811	
812	may play an important role in the apoptotic process, possibly within the modified cytoskeleton. its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.
813	
814	
815	
816	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
817	
818	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
819	
820	
821	catalyzes the initial reaction in o-linked oligosaccharide biosynthesis, the transfer of an n-acetyl-d- galactosamine residue to a serine or threonine residue on the protein receptor. has a broad spectrum of substrates for peptides such as ea2, muc5ac, muc1a, muc1b and muc7.
822	
823	plays a role in limb and brain development. implicated in the transduction of shh signal (by similarity).
824	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to sites in the 5@#$%&-flanking sequence of its coding region with various affinities. the consensus sequences of the high and low affinity binding sites are 5@#$%&-taatga[cg]-3@#$%& and 5@#$%&-ctaatttt- 3@#$%&.
825	seems to have numerous potential physiological functions. binds to collagen, thrombospondin, anionic phospholipids and oxidized ldl. may function as a cell adhesion molecule. directly mediates cytoadherence of plasmodium falciparum parasitized erythrocytes. binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.
826	promotes guanine-nucleotide exchange on arf1. promotes the activation of arf through replacement of gdp with gtp.
827	
828	may be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors (potential).
829	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
830	probable pseudophosphatase. contains a ser residue instead of a conserved cys residue in the dsptpase catalytic loop which probably renders it catalytically inactive as a phosphatase. the binding pocket may be however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases.
831	binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes. in the absence of shh, ptc represses the constitutive signaling activity of smo. also regulates another target, the gli oncogene. intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. displays both floor plate- and motor neuron-inducing activity. the threshold concentration of n-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (by similarity).
832	energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. human mdr3 is not capable of conferring drug resistance. mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.
833	may act as a tumor suppressor.
834	since they lack a putative transactivation domain, the small mafs behave as transcriptional repressors when they dimerize among themselves. however, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific dna-binding sites. small maf proteins heterodimerize with fos and may act as competitive repressors of the nf-e2 transcription factor.
835	
836	transcription termination factor. binds to a 28 bp region within the trna(leu(uur)) gene at a position immediately adjacent to and downstream of the 16s rrna gene, this region comprises a tridecamer sequence critical for directing accurate termination. probably requires one or more components for termination activity.
837	
838	transports the calcitonin gene-related peptide type 1 receptor (calcrl) to the plasma membrane. acts as a receptor for adrenomedullin (am) together with calcrl.
839	
840	
841	
842	
843	
844	
845	involved in sperm-egg adhesion. upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. the cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. this protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.
846	lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes.
847	
848	
849	strong transcriptional activator (by similarity).
850	
851	catalyzes the covalent attachment of ubiquitin to other proteins. mediates the selective degradation of short-lived and abnormal proteins.
852	
853	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. li-cadherin may have a role in the morphological organization of liver and intestine. involved in intestinal peptide transport.
854	its role might be as part of the apparatus concerned with the nuclear events of the cell cycle.
855	
856	
857	this protein is associated with sn-rnp u2. it helps the a@#$%& protein to bind stem loop iv of u2 snrna (by similarity).
858	orphan receptor.
859	
860	tryptophan degradation.
861	
862	
863	
864	
865	
866	stimulatory or required for the translocation of secretory proteins across the er membrane.
867	interacts with a specific negative regulatory element (nre) 5@#$%&-aattcctctga-3@#$%& to mediate transcriptional repression of certain nk-kappa-b responsive genes. involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced inos promoter activity. also involved in the regulation of il-8 transcription.
868	plays an important role in the eukaryotic peptide chain initiation process.
869	catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl coa as substrates.
870	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
871	could be involved in calcium-dependent cell adhesion or intercellular interactions.
872	histone demethylase that specifically demethylates lys-9 and lys-36 residues of histone h3, thereby playing a central role in histone code. does not demethylate histone h3 lys-4, h3 lys-27 nor h4 lys-20. demethylates trimethylated h3 lys-9 and h3 lys-36 residue, while it has no activity on mono- and dimethylated residues. demethylation of lys residue generates formaldehyde and succinate.
873	may play an important role in trophoblast development and in the regulation of bone formation.
874	
875	
876	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction. interacts with beta-1 and beta-2, but not with beta-3.
877	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction. interacts with beta-1 and beta-2, but not with beta-3.
878	receptor for glutamate. the activity of this receptor is mediated by a g-protein that inhibits adenylate cyclase activity.
879	blocks the elongation and depolymerization of the actin filaments at the pointed end. the tmod/tm complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. may play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its n-terminus.
880	conversion of dopamine to noradrenaline.
881	may have an e3 ubiquitin ligase activity. may play a significant role in mediating the biological activity of the hiv-1 tat protein in vivo. binds specifically to the activation domain of hiv-1 tat and can also interact with the hiv-2 and eiav tat proteins in vivo.
882	
883	
884	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
885	involved in rna polymerase iii-mediated transcription. integral, tightly associated component of the dna-binding tfiiic2 subcomplex that directly binds trna and virus-associated rna promoters.
886	
887	
888	
889	
890	inhibits hemopoiesis and stimulate chemotaxis. chemotactic in vitro for thymocytes and activated t-cells, but not for b-cells, macrophages, or neutrophils. shows preferential activity towards naive t-cells. may play a role in mediating homing of lymphocytes to secondary lymphoid organs. binds to ccr7.
891	asymmetrically hydrolyzes ap4a to yield amp and atp. plays a major role in maintaining homeostasis.
892	forms a water-specific channel that provide kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. also slightly permeable to urea and glycerol. may play an important role in gastrointestinal tract water transport and in glycerol metabolism (by similarity).
893	forms a water-specific channel that provide kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. also slightly permeable to urea and glycerol. may play an important role in gastrointestinal tract water transport and in glycerol metabolism (by similarity).
894	
895	
896	endostatin potently inhibits angiogenesis (by similarity).
897	
898	
899	atp dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
900	receptor for obesity factor (leptin). on ligand binding, mediates signaling through jak2/stat3. involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. may play a role in reproduction. can also mediate the erk/fos signaling pathway (by similarity).
901	
902	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
903	not known. possible housekeeping role.
904	
905	
906	
907	
908	mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient. it is a tetrodotoxin-sensitive na(+) channel isoform. plays a role in pain mechanisms, especially in the development of inflammatory pain (by similarity).
909	involved in protein n-glycosylation. essential for the second step of the dolichol-linked oligosaccharide pathway.
910	
911	required for constitutive membrane traffic. inhibits gtpase-stimulated na(+)/h(+) exchange. also inhibits calcineurin phosphatase activity. required for activity of slc9a1/nhe1.
912	methylates the carboxyl group of the c-terminal leucine residue of protein phosphatase 2a catalytic subunits (ppp2ca) to form alpha-leucine ester residues (by similarity).
913	
914	human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin s but that differ in their specificity due to amino acid sequence differences. cystatin sn, with a pi of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase i than is cystatin s, although both inhibit ficin equally well.
915	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. binds poly(rg).
916	cell surface proteoglycan that bears heparan sulfate (by similarity).
917	collagen type iii occurs in most soft connective tissues along with type i collagen.
918	
919	
920	
921	
922	hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. contributes to the native pacemaker currents in heart (if) and in neurons (ih). activated by camp, and at 10-100 times higher concentrations, also by cgmp. may mediate responses to sour stimuli.
923	3@#$%&-exoribonuclease that has a preference for poly(a) tails of mrnas, thereby efficiently degrading poly(a) tails. exonucleolytic degradation of the poly(a) tail is often the first step in the decay of eukaryotic mrnas and is also used to silence certain maternal mrnas translationally during oocyte maturation and early embryonic development. interacts with both the 3@#$%&-end poly(a) tail and the 5@#$%&-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(a) tails. involved in nonsense-mediated mrna decay, a critical process of selective degradation of mrnas that contain premature stop codons. also involved in degradation of inherently unstable mrnas that contain au-rich elements (ares) in their 3@#$%& untranslated regions, possibly via its interaction with khsrp. probably mediates the removal of poly(a) tails of ares mrnas, which constitutes the first step of destabilization.
924	
925	
926	putative receptor involved in the development of neural and epithelial tissues.
927	
928	the steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. activated, but not phosphorylated, by hipk3.
929	
930	
931	
932	
933	
934	promotes the exchange of ras-bound gdp by gtp. this protein positively controls the level of cellular camp at start, the stage at which the yeast cell division cycle is triggered.
935	
936	
937	
938	
939	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes, such as ube2l3/ubcm4, and then transfers it to substrates.
940	
941	
942	has an effect on position-effect variegation.
943	
944	
945	
946	
947	microtubule-binding motor protein probably involved in neuronal axonal transport. in vitro, has a plus-end directed motor activity (by similarity).
948	degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules.
949	
950	functions as a renin and prorenin cellular receptor. may mediate renin-dependent cellular responses by activating erk1 and erk2. by increasing the catalytic efficiency of renin in agt/angiotensinogen conversion to angiotensin i, it may also play a role in the renin-angiotensin system (ras).
951	
952	acts as androgen receptor co-regulator that increases androgen receptor activity by modulating the receptors interdomain interaction. may play a role in embryonal development and tumor transformation or aspects of tumor progression.
953	
954	may be involved in growth regulation of b-cells.
955	
956	
957	cbf binds to the core site, 5@#$%&-pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, lck, il-3 and gm-csf promoters. cbfb enhances dna binding by runx1.
958	accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. all three isoforms alter the functional properties of kv1.4 and kv1.5. isoform kvb1.2 has no effect on kv1.1, kv1.2 or kv2.1.
959	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
960	may be involved in actively transporting phosphate into cells via na(+) cotransport in the renal brush border membrane. probably mediates 20-30% of the apical influx.
961	
962	platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. binding of this growth factor to its affinity receptor elicits a variety of cellular responses. it is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heal the wound.
963	involved in the presentation of foreign antigens to the immune system.
964	
965	
966	
967	
968	
969	possible role in cell-cell interactions. integrin alpha pat-1/beta pat-3 is a receptor for laminin. integrin alpha pat- 2/beta pat-3 recognizes the sequence r-g-d in its ligands (by similarity).
970	involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26s proteasome (by similarity).
971	
972	severs microtubules in vitro in an atp-dependent manner. this activity may promote rapid reorganization of cellular microtubule arrays, such as during disassembly of interphase microtubules at the g2-m transition. may also be required for microtubule release from the centrosome after nucleation. in mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux. in neurons, microtubule release within the cell body may allow their subsequent transport into neuronal processes by microtubule dependent motor proteins. this transport is required for axonal growth (by similarity).
973	
974	
975	
976	
977	may mediate a process in spermatogenesis or may play a role in sex ratio distortion.
978	
979	
980	
981	this protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
982	
983	may play a role in axon guidance (by similarity).
984	
985	
986	
987	probably involved in bone and dentin mineralization and renal phosphate reabsorption.
988	multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. may play an important role in development and differentiation. the function of yy1 as an activator or a repressor is specified by the presence of other proteins. for example it acts as a repressor in absence of adenovirus e1a protein but as an activator in its presence.
989	may have an important role in the development and/or progression of some cancers.
990	
991	could act as a modulator of transcription.
992	
993	
994	involved, with rad23 in spindle pole body duplication. involved in the ubiquitin-proteasome proteolytic pathway.
995	stimulates specifically the gtpase activity of ypt6.
996	may be involved in cell proliferation and cell motility.
997	probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.
998	core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal dna. component of several complexes which regulate chromatin metabolism. these include the type b histone acetyltransferase (hat) complex, which is required for chromatin assembly following dna replication; the core histone deacetylase (hdac) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodelling and histone deacetylase complex (the nurd complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the prc2/eed-ezh2 complex, which promotes repression of homeotic genes during development.
999	probably involved in redox regulation of the cell. regulates the activation of nf-kappa-b in the cytosol by a modulation of i-kappa-b-alpha phosphorylation.
1000	
1001	receptor for progesterone (by similarity).
1002	
1003	receptor for cxcl9, cxcl10 and cxcl11 and mediates the proliferation of human mesangial cells (hmc). isoform 2 is a receptor for cxcl4 and also mediates the inhibitory activities of cxcl9, cxcl10 and cxcl11 on the growth of human microvascular endothelial cells (hmvec). isoform 2 may play a role in angiogenesis. isoform 3 mediates activity of cxcl11.
1004	
1005	
1006	
1007	
1008	chromosomal protein that binds to methylated dna. it can bind specifically to a single methyl-cpg pair. it is not influenced by sequences flanking the methyl-cpgs. mediates transcriptional repression through interaction with histone deacetylase and the corepressor sin3a.
1009	
1010	
1011	component of the nua4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. the nua4 complex atpase and helicase activities seem to be, at least in part, contributed by the association of ruvbl1 and ruvbl2 with ep400. nua4 may also play a direct role in dna repair when directly recruited to sites of dna damage. also component of the msin3a complex which acts to repress transcription by deacetylation of nucleosomal histones.
1012	mediates estrogen action in various target organs.
1013	may play a role in the regulation of enzymatic activity in the liver. decrease of rgn leads to the dysregulation of calcium signaling in the aged liver.
1014	
1015	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
1016	
1017	
1018	
1019	
1020	
1021	
1022	
1023	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes.
1024	does not have alcohol dehydrogenase activity. binds nadp and acts through a one-electron transfer process. orthoquinones are the best substrates. may act in the detoxification of xenobiotics.
1025	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
1026	
1027	oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
1028	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
1029	may be responsible for potassium buffering action of glial cells in the brain. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. can be blocked by extracellular barium and cesium (by similarity).
1030	involved in complement regulation. can associate with lipoproteins and may play a role in lipid metabolism.
1031	
1032	involved in the base excision repair (ber) pathway, by catalyzing the poly(adp-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in dna metabolism. this modification follows dna damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of dna strand breaks.
1033	
1034	
1035	
1036	
1037	
1038	
1039	required for protein transport from the er to the golgi complex.
1040	affects the rate of fibrils formation. may have a primary role in collagen fibrillogenesis (by similarity).
1041	receptor for the fc region of complexed or aggregated immunoglobulins gamma. low affinity receptor. involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by b- cells. binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on b-cells (bcr), t-cells (tcr) or via another fc receptor. isoform iib1 fails to mediate endocytosis or phagocytosis. isoform iib2 does not trigger phagocytosis.
1042	
1043	
1044	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. may play a role in leukemogenesis.
1045	may be involved in intracellular transport.
1046	inhibits the binding of prostaglandin f2-alpha (pgf2- alpha) to its specific fp receptor, by decreasing the receptor number rather than the affinity constant. functional coupling with the prostaglandin f2-alpha receptor seems to occur (by similarity).
1047	
1048	
1049	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein.
1050	
1051	catalyzes the exchange of eukaryotic initiation factor 2-bound gdp for gtp.
1052	cytosolic crabps may regulate the access of retinoic acid to the nuclear retinoic acid receptors. crabp2 may participate in a regulatory feedback mechanism to control the action of retinoic acid on cell differentiation.
1053	
1054	may selectively regulate the apical recycling and/or transcytotic pathways (by similarity).
1055	
1056	
1057	
1058	when complexed to birc5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized apaf1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. down-regulates hepatitis b virus (hbv) replication.
1059	
1060	
1061	
1062	nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. it stimulates division and differentiation of sympathetic and embryonic sensory neurons.
1063	receptor for the fc region of complexed immunoglobulins gamma. low affinity receptor.
1064	receptor for the fc region of complexed immunoglobulins gamma. low affinity receptor.
1065	receptor for the fc region of complexed immunoglobulins gamma. low affinity receptor.
1066	involved in the cornified cell envelope formation. multifunctional epidermal matrix protein.
1067	could be a dna-binding transcriptional regulator. may be involved in chromatin modification and remodeling.
1068	directly associates with hs1, through binding to its n- terminal region. may function in promoting cell survival. may also associate with cortactin/ems1 in nonlymphoid cells.
1069	
1070	angiotensin-3 stimulates aldosterone release.
1071	promotes apoptosis, pro-caspase-9 maturation and activation of nf-kappa-b via nik and ikk. may be an adapter protein between upstream tnfr1-tradd-rip complex and the downstream nik-ikk-ikap complex.
1072	
1073	
1074	
1075	
1076	can reduce the dialdehyde protein-binding form of aflatoxin b1 (afb1) to the nonbinding afb1 dialcohol. may be involved in protection of liver against the toxic and carcinogenic effects of afb1, a potent hepatocarcinogen (by similarity).
1077	catalyzes specific phosphoryl transfer from atp to ump and cmp.
1078	
1079	
1080	probable guanine nucleotide exchange factor.
1081	alpha-l-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end n- acetylglucosamine of the carbohydrate moieties of glycoproteins.
1082	cytokine that binds to tnfrsf18/aitr/gitr. important for interactions between activated t-lymphocytes and endothelial cells and may modulate t-lymphocyte survival in peripheral tissues.
1083	
1084	
1085	catalyzes the deimination of arginine residues of proteins (by similarity).
1086	
1087	
1088	
1089	
1090	putative odorant receptor.
1091	
1092	
1093	
1094	
1095	
1096	required for the proper development and maintenance of neurons presumably by affecting rna metabolism.
1097	
1098	type i collagen is a member of group i collagen (fibrillar forming collagen).
1099	
1100	
1101	
1102	
1103	
1104	possible role in phototransduction.
1105	
1106	
1107	
1108	involved in the splicing process and participates in early heat shock-induced splicing arrest. due to their great structural variations the different isoforms may possess different functions in the splicing reaction.
1109	
1110	
1111	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
1112	
1113	
1114	converts phytanoyl-coa to 2-hydroxyphytanoyl-coa.
1115	regulates eif4e activity by preventing its assembly into the eif4f complex. mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the map kinase pathway.
1116	
1117	binds to the pu-box, a purine-rich dna sequence (5@#$%&- gaggaa-3@#$%&) that can act as a lymphoid-specific enhancer. this protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or b- cells. also binds rna and may modulate pre-mrna splicing (by similarity).
1118	the jnk-interacting protein (jip) group of scaffold proteins selectively mediates jnk signaling by aggregating specific components of the mapk cascade to form a functional jnk signaling module. required for jnk activation in response to excitotoxic stress. cytoplasmic mapk8ip1 causes inhibition of jnk- regulated activity by retaining jnk in the cytoplasm and inhibiting jnk phosphorylation of c-jun. may also participate in apoer2-specific reelin signaling. directly, or indirectly, regulates glut2 gene expression and beta-cell function. appears to have a role in cell signaling in mature and developing nerve terminals. may function as a regulator of vesicle transport, through interactions with the jnk-signaling components and motor proteins (by similarity). functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.
1119	necessary for the splicing of pre-mrna. it is required for formation of the earliest atp-dependent splicing complex and interacts with spliceosomal components bound to both the 5@#$%& and 3@#$%& splice sites during spliceosome assembly. it also is required for atp-dependent interactions of both u1 and u2 snrnps with pre-mrna (by similarity). can bind to the myelin basic protein (mbp) gene mb3 regulatory region and increase transcription of the mbp promoter in cells derived from the cns.
1120	
1121	involved in the conversion of lanosterol to cholesterol.
1122	
1123	cleaves arg-arg-beta-naphthylamide.
1124	may play a role in fat metabolism.
1125	required for checkpoint mediated cell cycle arrest in response to dna damage or the presence of unreplicated dna. may also negatively regulate cell cycle progression during unperturbed cell cycles. recognizes the substrate consensus sequence [r-x-x- s/t]. binds to and phosphorylates cdc25a, cdc25b and cdc25c. phosphorylation of cdc25a at ser-178 and thr-507 and phosphorylation of cdc25c at ser-216 creates binding sites for 14- 3-3 proteins which inhibit cdc25a and cdc25c. phosphorylation of cdc25a at ser-76, ser-124, ser-178, ser-279 and ser-293 promotes proteolysis of cdc25a. inhibition of cdc25 activity leads to increased inhibitory tyrosine phosphorylation of cdk-cyclin complexes and blocks cell cycle progression. binds to and phosphorylates rad51 at thr-309, which may enhance the association of rad51 with chromatin and promote dna repair by homologous recombination. binds to and phosphorylates tlk1 at ser-743, which prevents the tlk1-dependent phosphorylation of the chromatin assembly factor asf1a. this may affect chromatin assembly during s phase or dna repair. may also phosphorylate multiple sites within the c-terminus of tp53, which promotes activation of tp53 by acetylation and enhances suppression of cellular proliferation.
1126	
1127	
1128	
1129	
1130	has heparin binding activity, and growth promoting activity. involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. also involved in early fetal adrenal gland development (by similarity).
1131	modulates channel gating kinetics. causes unique persistent sodium currents. inactivates the sodium channel opening more slowly than the beta-1 subunit. its association with neurofascin may target the sodium channels to the nodes of ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (by similarity).
1132	acts as a @#$%!third messenger@#$%! substrate of protein kinase c-mediated molecular cascades during synaptic development and remodeling. binds to calmodulin in the absence of calcium (by similarity).
1133	
1134	amp deaminase plays a critical role in energy metabolism.
1135	
1136	this protein may be involved in the regulation of b-cell activation and proliferation.
1137	component of heterochromatin. recognizes and binds histone h3 tails methylated at lys-9, leading to epigenetic repression. can interact with lamin b receptor (lbr). this interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. involved in the formation of functional kinetochore through interaction with mis12 complex proteins.
1138	tumor suppressor that may be involved in interferon- dependent cell death.
1139	may be involved in protein-protein interaction.
1140	
1141	
1142	
1143	
1144	switches off fancd2-mediated dna repair by promoting fancd2 deubiquitination.
1145	
1146	
1147	binds galactosides. may play a role in thymocyte- epithelial interactions relevant to the biology of the thymus. the isoform short acts as an eosinophil chemoattractant. is a ligand for havcr2/tim3. induces t-helper type 1 lymphocyte (th1) death.
1148	may act as a modulator of the olfactory signal- transduction cascade.
1149	
1150	
1151	terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. may be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses.
1152	may function in pre-mrna splicing.
1153	
1154	may play a role in a erbb3-regulated signal transduction pathway. seems be involved in growth regulation. acts a corepressor of the androgen receptor (ar) and is regulated by the erbb3 ligand neuregulin-1/heregulin (hrg). inhibits transcription of some e2f1-regulated promoters, probably by recruiting histone acetylase (hat) activity. binds rna. associates with 28s, 18s and 5.8s mature rrnas, several rrna precursors and probably u3 small nucleolar rna. may be involved in regulation of intermediate and late steps of rrna processing. may be involved in ribosome assembly (by similarity). mediates cap-independent translation of specific viral iress (internal ribosomal entry site). together with ptbp1 is required for the translation initiation on the foot- and-mouth disease virus (fmdv) ires.
1155	
1156	
1157	
1158	receptor for prostaglandin f2-alpha (pgf2-alpha). the activity of this receptor is mediated by g proteins which activate a phosphatidylinositol-calcium second messenger system. initiates luteolysis in the corpus luteum (by similarity).
1159	developmental protein required for reliable formation of primary and axillary shoot apical meristems. may be a component of a hypothetical meristem forming competence factor.
1160	causes the formation of thin, actin-rich surface projections called filopodia. functions cooperatively with cdc42 and rac to generate additional structures, increasing the diversity of actin-based morphology.
1161	
1162	
1163	acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
1164	selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
1165	
1166	
1167	
1168	
1169	is able to inhibit all four classes of proteinases by a unique @#$%&trapping@#$%& mechanism. this protein has a peptide stretch, called the @#$%&bait region@#$%& which contains specific cleavage sites for different proteinases. when a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. the entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
1170	
1171	involved in lymphocyte activation. binds to hla class-ii antigens.
1172	binds preferentially single-stranded dna and unwinds double stranded dna.
1173	
1174	
1175	
1176	
1177	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. mct2 is a high affinity pyruvate transporter.
1178	associated with snrnp u1, u2, u4/u6 and u5.
1179	
1180	
1181	forms a water-specific channel. implicated in the generation of saliva, tears, and pulmonary secretions.
1182	this is a receptor for retinoic acid. this metabolite has profound effects on vertebrate development. retinoic acid is a morphogen and is a powerful teratogen. this receptor controls cell function by directly regulating gene expression.
1183	protein tyrosine phosphatase which stimulates progression from g1 into s phase during mitosis. promotes tumors. inhibits geranylgeranyl transferase type ii activity by blocking the association between rabggta and rabggtb.
1184	
1185	
1186	promotes the exchange of gsp1/gsp2-bound gdp by gtp. involved in yeast pheromone response pathway and in mrna metabolism. probably involved in the control of nuclear organization.
1187	poly[adp-ribose] polymerase modifies various nuclear proteins by poly(adp-ribosyl)ation. the modification is dependent on dna and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from dna damage.
1188	
1189	
1190	single-stranded structure-specific dna endonuclease involved in dna excision repair. makes the 3@#$%&incision in dna nucleotide excision repair (ner). acts as a cofactor for a dna glycosylase that removes oxidized pyrimidines from dna. may also be involved in transcription-coupled repair of this kind of damage, in transcription by rna polymerase ii, and perhaps in other processes too.
1191	
1192	high-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. may also function as an ecotropic retroviral leukemia receptor.
1193	
1194	cleaves proteins, imported into the mitochondrion, to their mature size.
1195	not known.
1196	transcription regulator that acts as a key regulator of lineage commitment of immature t-cell precursors. necessary and sufficient for commitment of cd4 lineage, while its absence causes cd8 commitment. development of immature t-cell precursors (thymocytes) to either the cd4 helper or cd8 killer t-cell lineages correlates precisely with their t-cell receptor specificity for major histocompatibility complex class ii or class i molecules, respectively. transcriptional repressor of the collagen col1a1 and col1a2 genes. may also function as a repressor of fibronectin and possibly other extracellular matrix genes (by similarity).
1197	initiates the extrinsic pathway of blood coagulation. serine protease that circulates in the blood in a zymogen form. factor vii is converted to factor viia by factor xa, factor xiia, factor ixa, or thrombin by minor proteolysis. in the presence of tissue factor and calcium ions, factor viia then converts factor x to factor xa by limited proteolysis. factor viia will also convert factor ix to factor ixa in the presence of tissue factor and calcium.
1198	cleaves the alpha-chain at multiple sites and the beta- chain between lys-53 and lys-54 but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. it does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. activates coagulation factor vii.
1199	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins. plays an essential role during mouse embryonic development.
1200	
1201	major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
1202	
1203	
1204	
1205	plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. sequence-specific dna-binding protein with a distinct binding specificity (by similarity).
1206	general activator of rna polymerase which utilizes different tfiiib complexes at structurally distinct promoters. the isoform 1 is involved in the transcription of trna, adenovirus va1, 7sl and 5s rna. isoform 2 is required for transcription of the u6 promoter.
1207	
1208	
1209	
1210	
1211	
1212	
1213	
1214	interacts with the viral protein-binding domain of the retinoblastoma protein.
1215	
1216	
1217	promotes the exchange of ras-bound gdp by gtp (by similarity).
1218	fk506- and rapamycin-binding proteins (fkbps) constitute a family of receptors for the two immunosuppressants which inhibit t-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. ppiases accelerate the folding of proteins.
1219	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters. represses transcription from promoters with atf sites. it may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (by similarity).
1220	cochaperone that stimulates hsp90 atpase activity (by similarity). may affect a step in the endoplasmic reticulum to golgi trafficking.
1221	this enzyme is necessary for target cell lysis in cell- mediated immune responses. it cleaves after asp. seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
1222	
1223	interacts with key regulators (cbp, p300 and pcaf) of transcription and represses transcription. acts as a histone- binding protein that regulates transcription. acts as a deubiquitinating enzyme.
1224	plays an important role in the eukaryotic peptide chain initiation process.
1225	processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. involved in melanosome transport. may also be required for some polarization process involved in dendrite formation.
1226	
1227	probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment.
1228	
1229	may play a role in the reorganization of neuronal actin structure.
1230	
1231	
1232	involved in nucleolar processing of pre-18s ribosomal rna (by similarity).
1233	
1234	unknown.
1235	
1236	
1237	may transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of n-linked oligosaccharides of glycoproteins and may be involved in psa (polysialic acid) expression.
1238	not known, could be a tyrosine-phosphatase.
1239	
1240	may be involved in protection of cells from uv-induced cell death.
1241	
1242	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity). overexpression may be associated with abnormal proliferation in human breast tissue.
1243	the muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of g proteins. primary transducing effect is pi turnover.
1244	cytosolic crabps may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
1245	
1246	
1247	
1248	the glycine cleavage system catalyzes the degradation of glycine. the h protein shuttles the methylamine group of glycine from the p protein to the t protein.
1249	
1250	
1251	
1252	
1253	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of calcium (by similarity).
1254	
1255	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. the core protein 2 is required for the assembly of the complex.
1256	
1257	
1258	
1259	
1260	may play an important role in fibrillogenesis by controlling lateral growth of collagen ii fibrils.
1261	
1262	capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. also has 20-alpha-hsd activity. uses nadh while edh17b3 uses nadph.
1263	type i collagen is a member of group i collagen (fibrillar forming collagen).
1264	
1265	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
1266	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form.
1267	may be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.
1268	transfers a sulfuryl group to an n-unsubstituted glucosamine linked to a 2-o-sulfo iduronic acid unit on heparan sulfate. catalyzes the o-sulfation of glucosamine in glca2s-glcns. unlike 3-ost-1, does not convert nonanticoagulant heparan sulfate to anticoagulant heparan sulfate.
1269	may be required for cell division and may have a role during g1 or s phase.
1270	required for intramitochondrial proteolysis. catalyzes the initial steps of protein degradation.
1271	this protein seems to be functional equivalent to rat prostatic spermine-binding protein, which is involved in polyamine binding.
1272	
1273	probable transcription activator for a number of lung- specific genes.
1274	transcriptional activator that binds to the at-rich core sequence of the enhancer element of the afp gene.
1275	
1276	thiolesterase that catalyzes the hydrolysis of s-d- lactoyl-glutathione to form glutathione and d-lactic acid.
1277	interacts with dnak and grpe to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnak-independent fashion. unfolded proteins bind initially to dnaj; upon interaction with the dnaj-bound protein, dnak hydrolyzes its bound atp, resulting in the formation of a stable complex. grpe releases adp from dnak; atp binding to dnak triggers the release of the substrate protein, thus completing the reaction cycle. several rounds of atp-dependent interactions between dnaj, dnak and grpe are required for fully efficient folding.
1278	
1279	probable trna acetyltransferase required for the formation of the modified nucleoside n(4)-acetylcytidine in serine and leucine trnas. binds rna.
1280	
1281	
1282	
1283	
1284	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of calcium out of the cell.
1285	
1286	dual specificity kinase. is activated by cytokines and environmental stress in vivo. catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the map kinase p38.
1287	
1288	
1289	binds and transports cholesterol. promotes steroidogenesis in placenta and brain.
1290	
1291	probable adapter protein involved in signaling pathways. interacts with the sh2 and sh3 domains of various signaling proteins when it is phosphorylated. may promotes fyn activation, possibly by disrupting intramolecular sh3-dependent interactions (by similarity).
1292	
1293	
1294	clathrin is the major protein of the polyhedral coat of coated pits and vesicles. two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-golgi network.
1295	
1296	
1297	
1298	responsible for the reduction of the keto group on the c-3 of sterols.
1299	
1300	positive effector of the eif-2-alpha kinase activity of gcn2.
1301	
1302	
1303	recognizes and binds the 7-methylguanosine-containing mrna cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mrnas secondary structures.
1304	recognizes and binds the 7-methylguanosine-containing mrna cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mrnas secondary structures.
1305	
1306	
1307	transcriptional regulator involved in development.
1308	
1309	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
1310	mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. the receptor recognizes terminal galactose and n-acetylgalactosamine units. after ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. the receptor then returns to the cell membrane surface.
1311	creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
1312	
1313	functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (nls) in cargo substrates, or by acting as autonomous nuclear transport receptor. acting autonomously, serves itself as nls receptor. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran-dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. mediates autonomously the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in association with ipo7 mediates the nuclear import of h1 histone. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones.
1314	
1315	may play a role in neoplasia. may counteract a default induction of apoptosis in g2/m phase. interacts with tubulin. inhibitor of caspase-3 and caspase-7.
1316	control of topological states of dna by transient breakage and subsequent rejoining of dna strands. topoisomerase ii makes double-strand breaks.
1317	
1318	
1319	required for proper activation of rho gtpases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via nmda receptors. non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (paf) by removing the acetyl group at the sn-2 position (by similarity). positively regulates the activity of the minus-end directed microtubule motor protein dynein. may enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. required for several dynein- and microtubule-dependent processes such as the maintenace of golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. during nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. may also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.
1320	
1321	
1322	
1323	
1324	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
1325	
1326	may play a role in the proliferation or differentiation of keratinocytes.
1327	
1328	
1329	
1330	
1331	may be involved in transcriptional regulation.
1332	
1333	ena/vasp proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodelling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. vasp promotes actin nucleation and increases the rate of actin polymerization in the presence of capping protein. plays a role in actin-based activity of listeria monocytogenes in platelets (by similarity).
1334	
1335	retains nfe2l2/nrf2 in the cytosol thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression (by similarity).
1336	adhesion molecule that binds to leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2).
1337	
1338	binds to the caccc box in the beta-globin gene promoter and activates transcription (by similarity).
1339	cytokine that binds to tnfrsf7/cd27. plays a role in t- cell activation. induces the proliferation of costimulated t-cells and enhances the generation of cytolytic t-cells.
1340	essential component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. recruits mitochondrial hsp70 to drive protein translocation into the matrix using atp as an energy source.
1341	hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. potentially links obesity to diabetes.
1342	
1343	
1344	hydrolyzes dna under acidic conditions with a preference for double-stranded dna. plays a major role in the degradation of nuclear dna in cellular apoptosis during development. necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear dna expelled from erythroid precursor cells.
1345	
1346	
1347	essential component of the nuclear pore complex. the n- terminal is probably involved in nucleocytoplasmic transport. the c-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex.
1348	transcriptional activator which binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. its transcriptional activity is enhanced by ccnd3 and slightly inhibited by cdk4.
1349	putative transcription factor that binds to the sph and gt-iic @#$%!enhansons@#$%! (5@#$%&-gtggaatgt-3@#$%&). may be involved in the gene regulation of neural development. binds to the m-cat motif (by similarity).
1350	may act as effector for golgi-bound hras and other ras- like proteins. may promote hras-mediated transformation.
1351	
1352	probably involved in cell proliferation and cell-cell interactions.
1353	promotes guanine-nucleotide exchange on arf1, arf3 and arf6. promotes the activation of arf through replacement of gdp with gtp.
1354	
1355	
1356	
1357	negatively modulates rna polymerase ii function by binding to rpb5.
1358	
1359	may have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor.
1360	
1361	cytokine that drives rapid clonal expansion of naive but not memory cd4(+) t-cells. it also strongly synergizes with il-12 to trigger ifn-gamma production of naive cd4(+) t-cells. mediates its biologic effects through the cytokine receptor wsx-1/tccr.
1362	
1363	may antagonize nodal signaling and subsequent organization of axial structures during mesodermal patterning (by similarity).
1364	
1365	
1366	required for correct progression through g2 phase of the cell cycle and entry into mitosis. required for rcor1/corest mediated repression of neuronal specific gene promoters.
1367	factor d cleaves factor b when the latter is complexed with factor c3b, activating the c3bbb complex, which then becomes the c3 convertase of the alternate pathway. its function is homologous to that of c1s in the classical pathway.
1368	forms a voltage-independent potassium channel activated by intracellular calcium. activation is followed by membrane hyperpolarization. thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. the channel is blocked by apamin.
1369	
1370	acts on epoxides (alkene oxides, oxiranes) and arene oxides. plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. also determines steady-state levels of physiological mediators. has phosphatase activity (by similarity).
1371	
1372	
1373	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. involved in the interferon/all-trans-retinoic acid (ifn/ra) induced cell death. this apoptotic activity is inhibited by interaction with viral irf1. prevents the transactivation of stat3 target genes. may play a role in card15- mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
1374	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. l is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes.
1375	endogenous activator of intestinal guanylate cyclase. it stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
1376	
1377	binds vldl and transports it into cells by endocytosis. in order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. binding to reelin induces tyrosine phosphorylation of dab1 and modulation of tau phosphorylation (by similarity).
1378	
1379	may be involved in transcriptional regulation.
1380	
1381	prevents motor-neuron apoptosis induced by a variety of signals.
1382	terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. may play a role in regulation of glycine levels in nmda receptor-mediated neurotransmission.
1383	
1384	
1385	inhibits glucokinase by forming an inactive complex with this enzyme.
1386	receptor for members of the ephrin-a family. binds to ephrin-a1, -a4 and -a5. binds more poorly to ephrin-a2 and -a3. may play a role in a signal transduction process involved in hindbrain pattern formation.
1387	
1388	
1389	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters.
1390	
1391	might be a stress protein involved in the control of bacterial proliferation.
1392	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
1393	involved in redox regulation of the cell. reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. may play an important role in eliminating peroxides generated during metabolism. might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of h(2)o(2).
1394	stimulates transcription from the hsp70 promoter.
1395	involved in circadian rhythms, viability and molecular oscillations of the clock genes period (per) and timeless (tim). dbt reduces the stability and thus the accumulation of monomeric per proteins, probably through phosphorylation. no evident circadian oscillation is detected in head.
1396	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
1397	
1398	
1399	factor that represses transcription. it binds to the gc- rich sequences (5@#$%&-gcggggc-3@#$%&) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters.
1400	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
1401	collagen type iv is specific for basement membranes.
1402	
1403	
1404	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis (by similarity).
1405	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
1406	
1407	
1408	
1409	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. acts on the anterior body structures. seems to act in the maintenance and/or generation of hindbrain segments.
1410	acts preferentially on the c-jun n-terminal kinase (jnk) and p38 mapks. plays an important role in the heavy metal stress response by negatively regulating the kgb-1 (jnk-like) and the pmk-1 (p38-type) mapk signaling pathways.
1411	
1412	seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. isoform a1 binds only to the receptor edar, while isoform a2 binds exclusively to the receptor xedar.
1413	
1414	microtubule-based anterograde translocator for membranous organelles (by similarity).
1415	involved in transport of proteins into the mitochondrion.
1416	
1417	
1418	
1419	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
1420	
1421	
1422	may play a role in spermatogenesis.
1423	sequence-specific dna-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. ap-2 factors bind to the consensus sequence 5@#$%&-gccnnnggc-3@#$%& and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. they also suppress a number of genes including mcam/muc18, c/ebp alpha and myc.
1424	presumably involved in the processing and regular turnover of intracellular proteins. catalyzes the removal of unsubstituted n-terminal amino acids from various peptides.
1425	
1426	
1427	protease involved in mll processing and, consequently, in the correct expression of the early hoxa gene cluster.
1428	acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane (by similarity).
1429	
1430	may be involved in the pdh (pyruvate dehydrogenase complex) bypass.
1431	
1432	
1433	responsible for the modification of a37 to isopentenyl a37 of both cytosolic and mitochondrial trnas.
1434	
1435	
1436	
1437	may play a role in the processes of lymphocyte homing to secondary lymphoid organs.
1438	
1439	may be involved in the nuclear localization pathway of mcm3.
1440	has deoxyribonuclease activity. it is endonucleolytic with single-strand and exonucleolytic with double-strand dna. may play an important role in cell development as well as dna repair and recombination.
1441	this protein mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
1442	involved in the transport of the cationic amino acids (arginine, lysine and ornithine).
1443	
1444	may bind glycan structure with high affinity, but not heparin. has no chitotriosidase activity.
1445	converts n-carbamyl-beta-aminoisobutyric acid and n- carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide.
1446	
1447	transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (upr). acts during endoplasmic reticulum stress (er) by activating unfolded protein response (upr) target genes via direct binding to the upr element (upre). binds dna preferably to the cre-like element 5@#$%&- gatgacgtg[tg]n(3)[at]t-3@#$%&, and also to some tpa response elements (tre). binds to the hla dr-alpha promoter. binds to the tax- responsive element (tre) of htlv-i.
1448	
1449	catalyzes the sulfation of membrane glycolipids. seems to prefer beta-glycosides at the nonreducing termini of sugar chains attached to a lipid moiety. catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (by similarity). also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro).
1450	heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. biliverdin is subsequently converted to bilirubin by biliverdin reductase. under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
1451	high affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
1452	this protein binds beta-galactoside. its physiological function is not yet known.
1453	
1454	
1455	
1456	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters. it binds to a tax-responsive enhancer element in the long terminal repeat of htlv-i.
1457	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters. it binds to a tax-responsive enhancer element in the long terminal repeat of htlv-i.
1458	single stranded dna-dependent atp-dependent helicase. has a role in chromosome translocation. the dna helicase ii complex binds preferentially to fork-like ends of double-stranded dna in a cell cycle-dependent manner. it works in the 3@#$%&-5@#$%& direction. binding to dna may be mediated by p70. involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination. the ku p70/p86 dimer acts as regulatory subunit of the dna-dependent protein kinase complex dna-pk by increasing the affinity of the catalytic subunit prkdc to dna by 100-fold. the ku p70/p86 dimer is probably involved in stabilizing broken dna ends and bringing them together. the assembly of the dna-pk complex to dna ends is required for the nhej ligation step. required for osteocalcin gene expression (by similarity).
1459	single stranded dna-dependent atp-dependent helicase. has a role in chromosome translocation. the dna helicase ii complex binds preferentially to fork-like ends of double-stranded dna in a cell cycle-dependent manner. it works in the 3@#$%&-5@#$%& direction. binding to dna may be mediated by p70. involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination. the ku p70/p86 dimer acts as regulatory subunit of the dna-dependent protein kinase complex dna-pk by increasing the affinity of the catalytic subunit prkdc to dna by 100-fold. the ku p70/p86 dimer is probably involved in stabilizing broken dna ends and bringing them together. the assembly of the dna-pk complex to dna ends is required for the nhej ligation step. required for osteocalcin gene expression (by similarity).
1460	
1461	not known; could have a tyrosine ligase activity.
1462	
1463	
1464	
1465	
1466	the 83 kda subunit binds and stabilizes the catalytic subunit at 37 degrees celsius and keeps it in circulation. under some circumstances it may be an allosteric modifier of the catalytic subunit.
1467	probably involved in a neuron-specific signal transduction.
1468	plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility. binds to c1q (by similarity).
1469	required for sufficient glycogen accumulation. the alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule and, consequently, in reducing the osmotic pressure within cells.
1470	control of topological states of dna by transient breakage and subsequent rejoining of dna strands. topoisomerase ii makes double-strand breaks.
1471	
1472	receptor for udp-glucose and other udp-sugar coupled to g-proteins. not activated by atp, adp, utp or atp.
1473	
1474	exports cytoplasmic heme. may be required to protect developing erythroid cells from heme toxicity. causes susceptibility to felv-c in vitro.
1475	
1476	
1477	calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes like transcriptional regulation, hormone production, translational regulation, regulation of actin filament organization and neurite outgrowth. involved in calcium- dependent activation of the erk pathway (by similarity). recognizes the substrate consensus sequence [mvlif]-x-r-x(2)-[st]- x(3)-[mvlif]. phosphorylates eif4g3/eif4gii. in vitro phosphorylates creb1, atf1, ctfr, myl9, syn1/synapsin i and synii/synapsin ii (by similarity).
1478	e3 ring-finger protein, member of the ubc2/rad6 epistasis group. associates to the e2 ubiquitin conjugating enzyme ubc2/rad6 to form the ubc2-rad18 ubiquitin ligase complex involved in postreplicative repair (prr) of damaged dna. the ubc2-rad18 complex cooperates with rad5 and the ubc13-mms2 dimer to attach mono-ubiquitin chains on lys-164 of pol30, which is necessary for prr. the ubc2-rad18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine.
1479	
1480	atp-dependent rna helicase which is a subunit of the eif4f complex involved in cap recognition and is required for mrna binding to ribosome. in the current model of translation initiation, eif4a unwinds rna secondary structures in the 5@#$%& untranslated region of mrnas which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
1481	cytokine that binds to tnfrsf10a/trailr1, tnfrsf10b/trailr2, tnfrsf10c/trailr3, tnfrsf10d/trailr4 and possibly also to tnfrsf11b/opg. induces apoptosis. its activity may be modulated by binding to the decoy receptors tnfrsf10c/trailr3, tnfrsf10d/trailr4 and tnfrsf11b/opg that cannot induce apoptosis.
1482	actin-binding protein involved in motile and morphological processes. inhibits actin polymerization, likely by sequestering g-actin. prevents actin filament assembly by forming a 1:1 complex with actin monomers, and inhibits the nucleotide exchange reaction of actin monomers (by similarity).
1483	seems to act exclusively upon threonine residues (by similarity).
1484	
1485	
1486	
1487	
1488	binds preferentially single-stranded dna and unwinds double stranded dna.
1489	
1490	
1491	this protein binds 5s rna.
1492	
1493	tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. directly dephosphorylates cdc2 and stimulates its kinase activity. also dephosphorylates cdk2 in complex with cyclin e, in vitro.
1494	
1495	lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. it acts at a late stage of megakaryocyte development. it may be the major physiological regulator of circulating platelets.
1496	
1497	costimulates t-cell proliferation. may regulate myeloid cell activity in a variety of tissues.
1498	
1499	
1500	
1501	may play a role in organizing the actin cytoskeleton of the brain cells.
1502	
1503	
1504	required maternally for proper expression of other homeotic genes involved in pattern formation, such as ubx.
1505	
1506	
1507	
1508	la-pf4 stimulates dna synthesis, mitosis, glycolysis, intracellular camp accumulation, prostaglandin e2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. it also stimulates the formation and secretion of plasminogen activator by human synovial cells. nap-2 is a ligand for cxcr1 and cxcr2, and nap-2, nap-2(73), nap-2(74), nap-2(1-66), and most potent nap-2(1-63) are chemoattractants and activators for neutrophils. tc-1 and tc-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. ctap-iii(1-81) is more potent than ctap-iii desensitize chemokine-induced neutrophil activation.
1509	involved in the functional recruitment of the sin3- histone deacetylase complex (hdac) to a specific subset of n-cor corepressor complexes. capable of transcription repression by n- cor. active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.
1510	histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). in addition, histatins exhibit antibacterial and antifungal activities.
1511	catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3@#$%&- diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.
1512	plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations (by similarity).
1513	may be involved in actively transporting phosphate into cells via na(+) cotransport. it may be the main phosphate transport protein in the intestinal brush border membrane. may have a role in the synthesis of surfactant in lungs@#$%& alveoli.
1514	rate limiting enzyme for synthesis of hsact. performs the crucial step modification in the biosynthesis of anticoagulant heparan sulfate (hsact) that is to complete the structure of the antithrombin pentasaccharide binding site.
1515	functions as a sorting receptor in the golgi compartment and as a clearance receptor on the cell surface. required for protein transport from the golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (m6pr). also required for protein transport from the golgi apparatus to the endosomes. promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of bdnf (probdnf) and ngfb (prongfb). also acts as a receptor for neurotensin. may promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular lpl. probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter slc2a4/glut4 (glut4 storage vesicles, or gsvs). these vesicles provide a stable pool of slc2a4 and confer increased responsiveness to insulin. may also mediate transport from the endoplasmic reticulum to the golgi.
1516	
1517	binds and presumably selects ubiquitin-conjugates for destruction. displays selectivity for longer polyubiquitin chains. modulates intestinal fluid secretion.
1518	seems to have both an inflammatory cytokine activity and trna-binding domain.
1519	chemotactic for b-lymphocytes but not for t-lymphocytes, monocytes and neutrophils. does not induce calcium release in b- lymphocytes. binds to blr1/cxcr5.
1520	
1521	inhibitor of phospholipase a2, also possesses anti- coagulant properties. also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
1522	
1523	
1524	may have a role in processing of pre-rrna or in the assembly of rrna into ribosomal subunits.
1525	
1526	
1527	
1528	
1529	
1530	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
1531	
1532	
1533	
1534	inhibitor of the caspase-activated dnase (dff40).
1535	
1536	
1537	might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. may supply selenium to tissues such as brain and testis.
1538	non-amyloid component of senile plaques found in alzheimer disease. could act as a regulator of snca aggregation process. protects neurons from staurosporine and 6 hydroxy dopamine (6ohda)-stimulated caspase activation in a p53-dependent manner. contributes to restore the snca anti-apoptotic function abolished by 6ohda. not found in the lewy bodies associated with parkinson disease.
1539	
1540	
1541	
1542	type i collagen is a member of group i collagen (fibrillar forming collagen).
1543	probable dna-repair protein.
1544	
1545	microtubule-based anterograde translocator for membranous organelles. plus end-directed microtubule sliding activity in vitro.
1546	pp2a can modulate the activity of phosphorylase b kinase casein kinase 2, mitogen-stimulated s6 kinase, and map-2 kinase. can dephosphorylate sv40 large t antigen and p53. dephosphorylates sv40 large t antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. the c subunit was most active, followed by the ac form, which was more active than the abc form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. dephosphorylation by the ac form, but not c or abc form is inhibited by small t antigen.
1547	may constitute a glutathionine peroxidase-like protective system against oxidative stresses (by similarity).
1548	
1549	
1550	necessary for cell polarization during vegetative growth. may link the cytoskeleton to morphogenic determinants on the cell surface.
1551	
1552	acts as an adapter protein of the fyn and sh2-domain- containing leukocyte protein-76 (slp76) signaling cascades in t cells. modulates the expression of interleukin-2 (il-2).
1553	receptor for motilin.
1554	catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.
1555	
1556	involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination. binds to dna and to dna ligase iv (lig4). the lig4-xrcc4 complex is responsible for the nhej ligation step, and xrcc4 enhances the joining activity of lig4. binding of the lig4-xrcc4 complex to dna ends is dependent on the assembly of the dna-dependent protein kinase complex dna-pk to these dna ends.
1557	essential for the control of the cell cycle at the g2/m (mitosis) transition.
1558	
1559	responsible for the posttranslational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. in addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.
1560	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. this is a component of the iron-sulfur (ip) fragment of the enzyme.
1561	
1562	possible dna-binding subunit of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.
1563	forms transcriptional repressor complexes by associating with mad, sin3, yy1 and n-cor. interacts in the late s-phase of dna-replication with dnmt1 in the other transcriptional repressor complex composed of dnmt1, dmap1, pcna, caf1.
1564	
1565	
1566	
1567	
1568	
1569	stimulates guanylyl cyclase 1 (gc1) when free calcium ions concentration is low and inhibits gc1 when free calcium ions concentration is elevated. this ca(2+)-sensitive regulation of gc is a key event in recovery of the dark state of rod photoreceptors following light exposure.
1570	may function in the secretion of milk-fat droplets. may act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (by similarity).
1571	
1572	may be involved in transcriptional regulation.
1573	
1574	
1575	
1576	
1577	essential component of the nelf complex, a complex that negatively regulates the elongation of transcription by rna polymerase ii. the nelf complex, which acts via an association with the dsif complex and causes transcriptional pausing, is counteracted by the p-tefb kinase complex.
1578	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
1579	the steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. activated, but not phosphorylated, by hipk3.
1580	
1581	
1582	
1583	
1584	
1585	
1586	
1587	
1588	
1589	
1590	probable hydrolase. involved in the thymus homing of bone marrow cells. may regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.
1591	
1592	molecular chaperone; assists the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
1593	
1594	
1595	involved in regulation of vitamin k-dependent carboxylation of multiple amino-terminal glutamate residues. seems to inhibit gamma-carboxylase ggcx. binds 7 calcium ions with a low affinity (by similarity).
1596	in vitro; can phosphorylate histones h3 and h2b on ser and thr residues. may be involved in the regulation of cellular growth and/or development.
1597	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
1598	plays a functional role in insulin and igf-i signaling. may serve to positively link the insulin and igf-i receptors to an uncharacterized mitogenic signaling pathway. interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. the interaction is mediated by the sh2 domain. also binds activated platelet-derived growth factor receptor and epidermal growth factor receptor.
1599	cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. endosomal acidification leads to iron release. the apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral ph and the concomitant loss of affinity of apotransferrin for its receptor. transferrin receptor is necessary for development of erythrocytes and the nervous system (by similarity). a second ligand, the heditary hemochromatosis protein hfe, competes for binding with transferrin for an overlapping c-terminal binding site.
1600	
1601	
1602	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i (by similarity).
1603	inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. inhibins appear to oppose the functions of activins.
1604	involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. acts in assocation with dock1 and crk. was initially proposed to be required in complex with dock1 to activate rac rho small gtpases. may enhance the guanine nucleotide exchange factor (gef) activity of dock1.
1605	
1606	may have an important role in regulating the access of circulating igfs to the tissues.
1607	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems. the g(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli.
1608	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
1609	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
1610	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
1611	
1612	
1613	required for the export of mrnas containing poly(a) tails from the nucleus into the cytoplasm. in case of infection by hiv-1, it may participate in the docking of viral vpr at the nuclear envelope.
1614	integrin alpha-v/beta-8 is a receptor for fibronectin.
1615	may act as a scaffolding protein within caveolar membranes. interacts directly with g-protein alpha subunits and can functionally regulate their activity. caveolin-2 may function as an accessory protein in conjunction with caveolin-1.
1616	
1617	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
1618	binds to type ii regulatory subunits of protein kinase a. scaffolding protein that assembles several protein kinases and phosphatases on centrosome and golgi apparatus where physiological events can be regulated by phosphorylation state of protein substrates. isoform 4/yotiao is associated with the n-methyl-d- aspartate receptor and is specifically found in the neuromuscular junction (nmj) as well as in neuronal synapses explaining that its role may be to organize postsynaptic specializations.
1619	energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. human mdr3 is not capable of conferring drug resistance. mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.
1620	
1621	the 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-coa and co(2). it contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (e1), dihydrolipoamide succinyltransferase (e2) and lipoamide dehydrogenase (e3).
1622	
1623	
1624	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
1625	chloride/bicarbonate exchanger. involved in absorbtion of in the colon. helps mediate electrolyte and fluid absorption.
1626	
1627	
1628	enhances pdgfa-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of pdgfb (by similarity).
1629	
1630	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
1631	
1632	
1633	
1634	catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the e1 component of the pyruvate dehydrogenase complex (by similarity).
1635	
1636	methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (can methylate hnrnpa1 and histones). methylates supt5h (by similarity).
1637	
1638	probably important in the regulation of neuronal excitability. associates with kcnq2 or kcnq5 to form a potassium channel with essentially identical properties to the channel underlying the native m-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.
1639	
1640	the 26s protease is involved in the atp-dependent degradation of ubiquitinated proteins. the regulatory (or atpase) complex confers atp dependency and substrate specificity to the 26s complex. interacts with the orphan nuclear hormone receptor mb67.
1641	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
1642	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. may govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
1643	
1644	
1645	type i collagen is a member of group i collagen (fibrillar forming collagen).
1646	
1647	
1648	plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. this phosphodiesterase is highly specific for camp and may have a role in muscle signal transduction.
1649	
1650	catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a thr-glu-tyr sequence located in map kinases. activates erk1 and erk2 map kinases.
1651	
1652	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
1653	
1654	
1655	
1656	plays a role in photoreceptor morphogenesis in the retina. may maintain cell polarization and adhesion.
1657	
1658	phosphorylates ins(1,3,4,5,6)p5 at position 2 to form ins(1,2,3,4,5,6)p6 (insp6 or phytate). insp6 is involved in many processes such as mrna export, nonhomologous end-joining, endocytosis, ion channel regulation. it also protects cells from tnf-alpha-induced apoptosis.
1659	the glycine cleavage system catalyzes the degradation of glycine. the p protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; co(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the h protein.
1660	tyrosine kinase of the non-receptor type, involved in interleukin 3 signal transduction.
1661	
1662	tyrosine-protein kinase receptor whose role is not yet clear.
1663	
1664	stimulates specifically the gtpase activity of ypt6.
1665	likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
1666	
1667	could play a role in taste reception. could be necessary for the concentration and delivery of sapid molecules in the gustatory system. can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. exhibits an extremely wide ligand pocket.
1668	
1669	
1670	
1671	
1672	catalyzes fat and vitamin absorption. acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.
1673	
1674	
1675	inhibitory regulator of the ras-cyclic amp pathway.
1676	may play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. may play an important role in trafficking of t-cells in thymus, and t-cell and b-cell migration to secondary lymphoid organs. specifically binds to chemokine receptor ccr7. recombinant scya19 shows potent chemotactic activity for t-cells and b-cells but not for granulocytes and monocytes.
1677	
1678	component of the exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna (by similarity).
1679	
1680	required for t-cell activation through the antigen receptor. the first ptpase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
1681	catalyzes the conversion of dtmp to dtdp.
1682	
1683	
1684	
1685	
1686	
1687	transcription factor that binds to sequence with multiple copies of ttc[cg]g present in its own promoter and that of the hnrpa2b1 gene. down-regulates transcription of these genes. binds to the retinoic acid response element (rare) agggttcaccgaaagttca. activates the proenkephalin gene independently of promoter binding, probably through protein- protein interaction. when secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the g0 or g1 phase.
1688	
1689	
1690	active on elastin and collagen substrates (by similarity).
1691	binds calcium. may be involved in terminal differentiation of keratinocytes.
1692	integrin alpha-m/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. it is identical with cr-3, the receptor for the ic3b fragment of the third complement component. it probably recognizes the r-g-d peptide in c3b. integrin alpha-m/beta-2 is also a receptor for fibrinogen, factor x and icam1. it recognizes p1 and p2 peptides of fibrinogen gamma chain.
1693	seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.
1694	
1695	
1696	
1697	
1698	
1699	facilitates nuclear export of spliced mrna by releasing the rna from the spliceosome.
1700	
1701	
1702	
1703	
1704	
1705	
1706	
1707	
1708	
1709	may be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.
1710	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. this receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. it is a cation-specific, but otherwise relatively nonselective, ion channel.
1711	involved in cell cycle checkpoint enforcement. can interact and phosphorylate bub3.
1712	seems to act exclusively upon threonine residues (by similarity).
1713	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase c. it could help neuronal cells to establish short- term memory.
1714	protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the golgi apparatus.
1715	
1716	receptor for complement c3dd, for the epstein-barr virus on human b-cells and t-cells and for hnrpu. participates in b lymphocytes activation.
1717	transcriptional repressor. mxi1 binds with max to form a sequence-specific dna-binding protein complex which recognizes the core sequence 5@#$%&-cac[ga]tg-3@#$%&. mxi1 thus antagonizes myc transcriptional activity by competing for max.
1718	tyrosine kinase of the non-receptor type. probably performs an important function, perhaps in regulatory processes such as cell cycle control.
1719	may be involved in transcriptional regulation.
1720	
1721	participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.
1722	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
1723	
1724	
1725	may have a regulatory role in phosphatidylcholine synthesis.
1726	plays a role in transcriptional coactivation. plays a role in nuclear hormone receptor-mediated transactivation.
1727	
1728	
1729	
1730	involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors.
1731	
1732	metastasis suppressor protein in malignant melanomas and in some breast cancers. may regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. generates a c-terminally amidated peptide, metastin which functions as the endogenous ligand of the g-protein coupled receptor gpr54. activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. kp-10, but not other kisspeptins, increased intracellular ca(2+) levels in isolated first trimester trophoblasts. kp-10 is a paracrine/endocrine regulator in fine- tuning trophoblast invasion generated by the trophoblast itself. the receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. the hypothalamic kiss1/gpr54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
1733	may mediate uptake of degraded synaptic material which could play an important role in synaptic remodeling. can mediate the neuronal and glial uptake of the snake venom toxin taipoxin (by similarity).
1734	aminopeptidase with broad substrate specificity to several peptides. involved in proteolytic events essential for cell growth and viability. may act as regulator of neuropeptide activity (by similarity).
1735	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form.
1736	
1737	
1738	
1739	
1740	plasma membrane-associated small gtpase which cycles between an active gtp-bound and inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.
1741	
1742	
1743	may be involved in transcriptional regulation.
1744	likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. may function in cell adhesion and signal transduction in the brain.
1745	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
1746	
1747	involved in the presentation of foreign antigens to the immune system.
1748	
1749	may play a role in organizing the actin cytoskeleton.
1750	regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
1751	cleaves a-5@#$%&-ppp-5@#$%&a to yield amp and adp. possible tumor suppressor for specific tissues.
1752	cleaves a-5@#$%&-ppp-5@#$%&a to yield amp and adp. possible tumor suppressor for specific tissues.
1753	
1754	thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. it is capable of binding to actin, calmodulin, troponin c and tropomyosin. the interaction of calponin with actin inhibits the actomyosin mg-atpase activity (by similarity).
1755	binds to the lim domain of a wide variety of lim domain- containing transcription factors.
1756	regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. regulates tp53 by enhancing the dna binding and transactivation function of tp53 on the promoters of proapoptotic genes in vivo. inhibits the ability of appbp1 to conjugate nedd8 to cul1, and thereby decreases appbp1 ability to induce apoptosis. impedes cell cycle progression at g2/m.
1757	functions in nuclear protein import as an adapter protein for nuclear receptor kpnb1. binds specifically and directly to substrates containing either a simple or bipartite nls motif. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus.
1758	chemotactic for interleukin-activated t-cells but not unstimulated t-cells, neutrophils or monocytes. induces calcium release in activated t-cells. binds to cxcr3. may play an important role in cns diseases which involve t-cell recruitment. may play a role in skin immune responses.
1759	
1760	
1761	may play a role in vesicular transport from endoplasmic reticulum to golgi.
1762	
1763	exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities.
1764	collagen type iii occurs in most soft connective tissues along with type i collagen.
1765	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex.
1766	c1r b chain is a serine protease that combines with c1q and c1s to form c1, the first component of the classical pathway of the complement system.
1767	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
1768	required for t-cell activation through the antigen receptor. the first ptpase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
1769	appears to function in the signal transduction from ras activation to actin cytoskeletal remodelling. suppresses insulin- induced promoter activities through ap1 and sre. mediates rap1- induced adhesion.
1770	
1771	
1772	
1773	
1774	may function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling.
1775	
1776	
1777	may play an important role in lipogenesis.
1778	may be an angiogenesis inhibitor.
1779	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
1780	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. active on long chain acyl-coas.
1781	probable transcriptional activator.
1782	
1783	atp-dependent rna helicase. acts as a cofactor for xpo1- mediated nuclear export of incompletely spliced hiv-1 rev rnas. also involved in hiv-1 replication. interacts specifically with hepatitis c virus core protein resulting in a change in intracellular location.
1784	required for the accumulation of coenzyme a in the mitochondrial matrix.
1785	
1786	
1787	
1788	
1789	
1790	involved in control of the cell cycle. upon lytic infection of permissive cells, the hsv transactivator protein vp16 associates with hcfc1. binding to hcfc1 activates vp16 for association with the octamer motif-binding protein pou2f1, to form a multiprotein-dna complex responsible for activating transcription of the hsv immediate early genes. also antagonizes transactivation by zbtb17 and gabp2; represses zbtb17 activation of the p15(ink4b) promoter and inhibits its ability to recruit p300. coactivator for egr2 and gabp2. tethers the chromatin modifying set1/ash2 histone h3-k4 methyltrasferase (hmt) and sin3 histone deacetylase (hdac) complexes (involved in the activation and repression of transcription, respectively) together.
1791	
1792	
1793	
1794	not known. binds to rna homopolymers, with a preference for poly(g) and poly(u) and little for poly(a) (by similarity).
1795	in addition to its role as a glycolytic enzyme, it seems that pgk-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
1796	
1797	
1798	
1799	c1q associates with the proenzymes c1r and c1s to yield c1, the first component of the serum complement system. the collagen-like regions of c1q interact with the ca(2+)-dependent c1r(2)c1s(2) proenzyme complex, and efficient activation of c1 takes place on interaction of the globular heads of c1q with the fc regions of igg or igm antibody present in immune complexes.
1800	transcription activator that binds dna cooperatively with dp proteins through the e2 recognition site, 5@#$%&-tttc[cg]cgc- 3@#$%& found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the drtf1/e2f complex functions in the control of cell-cycle progression from g1 to s phase. e2f-2 binds specifically to rb1 protein, in a cell-cycle dependent manner.
1801	appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. phosphorylation of dmd or utrn may modulate their affinities for associated proteins. functions in a multi-protein complex in spermatid maturation. regulates lipopolysaccharide-induced il-12 synthesis in macrophages by forming a complex with traf6, resulting in the inhibition of traf6 nf-kappab activation (by similarity).
1802	
1803	
1804	may be involved in transcriptional regulation.
1805	mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. may play a role in regulating steroidogenesis.
1806	weakly inward rectifying potassium channel.
1807	
1808	
1809	
1810	essential transmembrane gtpase, which mediates mitochondrial fusion. fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. mfn2 acts independently of the cytoskeleton. it therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. overexpression induces the formation of mitochondrial networks. plays an important role in the regulation of vascular smooth muscle cell proliferation.
1811	may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. binds two calcium ions.
1812	forms a voltage-independent potassium channel activated by intracellular calcium. activation is followed by membrane hyperpolarization. thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. the channel is blocked by apamin.
1813	
1814	a probable role in alternative splice site selection during pre-mrna splicing.
1815	may regulate vesicle trafficking and modulate the subcellular distribution of slc2a4/glut4-vesicles. has parp activity and can modify trf1, and thereby contribute to the regulation of telomere length.
1816	
1817	
1818	probable component of the protein complex eif4f, which is involved in the recognition of the mrna cap, atp-dependent unwinding of 5@#$%&-terminal secondary structure and recruitment of mrna to the ribosome. thought to be a functional homolog of eif4g1.
1819	
1820	putative transcription factor involved in embryogenesis and hematopoiesis. may play an important role in lymphocytes and certain developing tissues.
1821	degrades chitin and chitotriose. may participate in the defense against nematodes and other pathogens. isoform 3 has no enzymatic activity.
1822	
1823	
1824	receptor for the fc region of igg. binds complexed or aggregated igg and also monomeric igg. mediates antibody-dependent cellular cytotoxicity (adcc) and other antibody-dependent responses, such as phagocytosis.
1825	
1826	
1827	
1828	probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
1829	may be involved in spermatogenesis and fertilization.
1830	could act as a modulator of glutaredoxin biological activity.
1831	histone methyltransferase. methylates lys-9 of histone h3. h3 lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting hp1 proteins to methylated histones. targeted to histone by trim28/tif1b and contributes to silencing of euchromatic genes by krab zinc-finger proteins.
1832	histone methyltransferase. methylates lys-9 of histone h3. h3 lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting hp1 proteins to methylated histones. targeted to histone by trim28/tif1b and contributes to silencing of euchromatic genes by krab zinc-finger proteins.
1833	probable protein tyrosine-kinase transmembrane receptor.
1834	required for the first step of diphtamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from s-adenosyl-l- methionine to a histidine residue. diphthamide is a post- translational modification of histidine which occurs in elongation factor 2.
1835	
1836	
1837	
1838	trap proteins are part of a complex whose function is to bind calcium to the er membrane and thereby regulate the retention of er resident proteins.
1839	
1840	
1841	
1842	
1843	may play a role in the regulation of the immune system. seems to play a role as an inhibitor of apoptosis.
1844	
1845	
1846	forms a water-specific channel that provide kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. also slightly permeable to urea and glycerol. it may play an important role in gastrointestinal tract water transport and in glycerol metabolism.
1847	
1848	
1849	
1850	hydrolyzes dna under acidic conditions with a preference for double-stranded dna. plays a major role in the degradation of nuclear dna in cellular apoptosis during development. necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear dna expelled from erythroid precursor cells.
1851	capable of removing ubiquitin from ubiquitinated proteins; also capable of removing nedd8 from nedd8 conjugates but has no effect on sentrin-1 conjugates.
1852	
1853	thought to be a regulatory component of the atp- synthesizing complex in the mitochondria.
1854	component of pre-mrna cleavage complex ii and of the trna splicing endonuclease complex.
1855	inhibits the synthesis of a number of cytokines, including ifn-gamma, il-2, il-3, tnf and gm-csf produced by activated macrophages and by helper t-cells.
1856	f-actin capping proteins bind in a ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
1857	
1858	
1859	initiates blood coagulation by forming a complex with circulating factor vii or viia. the [tf:viia] complex activates factors ix or x by specific limited protolysis. tf plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
1860	
1861	saposin d is a specific sphingomyelin phosphodiesterase activator (ec 3.1.4.12).
1862	part of a complex implicated in the control of actin polymerization in cells.
1863	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
1864	cytokine that binds to tnfrsf4. co-stimulates t-cell proliferation and cytokine production.
1865	
1866	receptor for gdnf. mediates the gdnf-induced autophosphorylation and activation of the ret receptor (by similarity).
1867	microtubule-binding motor protein probably involved in neuronal dendritic transport. in vitro, has a plus-end directed motor activity (by similarity).
1868	involved in peroxisomal proliferation. may regulate peroxisomes division by recruiting the dynamin-related gtpase dnm1l to the peroxisomal membrane.
1869	receptor for tnfsf14/light and homotrimeric tnfsf1/lymphotoxin-alpha. involved in lymphocyte activation. plays an important role in hsv pathogenesis because it enhanced the entry of several wild-type hsv strains of both serotypes into cho cells, and mediated hsv entry into activated human t-cells.
1870	inhibits the binding of prostaglandin f2-alpha (pgf2- alpha) to its specific fp receptor, by decreasing the receptor number rather than the affinity constant. functional coupling with the prostaglandin f2-alpha receptor seems to occur.
1871	
1872	essential component of the tim23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
1873	
1874	segment polarity protein, functions together with arm to transduce the wingless (wg) signal. acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
1875	cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. binds to alb, mb, kappa and lambda-light chains, tf, hemoglobin, gc, scgb1a1, apoa1, high density lipoprotein, and the gif-cobalamin complex. the binding of all ligands required calcium. serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. interaction with lrp2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like gc, hemoglobin, alb, tf and scgb1a1. interaction with amn controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. may play an important role in the development of the peri-implantation embryo through internalization of apoa1 and cholesterol. binds to lgals3 at the maternal-fetal interface.
1876	straight-chain enoyl-coa thioesters from c4 up to at least c16 are processed, although with decreasing catalytic rate.
1877	
1878	may play a role in axon guidance (by similarity).
1879	
1880	
1881	
1882	
1883	
1884	
1885	a rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (erc) to the plasma membrane. also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (ptdinsp3) and phosphatidic acid (pa).
1886	
1887	
1888	involved in transport from the endoplasmic reticulum to the golgi apparatus (by similarity).
1889	
1890	participates in the second step of pre-mrna splicing.
1891	
1892	positively regulates the wnt signaling pathway by stabilizing beta-catenin through the association with gsk-3. may play a role in tumor progression and collaborate with pim1 and myc in lymphomagenesis.
1893	necessary for spliceosome assembly. overexpression causes apoptosis.
1894	
1895	receptor for interleukin-2.
1896	may play a significant role in aauaaa-independent mrna polyadenylation in germ cells. directly involved in the binding to pre-mrnas (by similarity).
1897	seems essential for mesoderm formation and subsequent organization of axial structures in early mouse development.
1898	macro-h2a occupies the place of conventional h2a in a subset of nucleosomes where it represses transcription. may be involved in stable x chromosome inactivation.
1899	
1900	
1901	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. component of the flavoprotein-sulfur (fp) fragment of the enzyme.
1902	the function of subunit 4 is not yet known.
1903	
1904	involved in repair of uv radiation-induced dna damage. catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same dna strand upon exposure to ultraviolet radiation.
1905	
1906	high affinity receptor for melatonin. likely to mediates the reproductive and circadian actions of melatonin. the activity of this receptor is mediated by pertussis toxin sensitive g proteins that inhibit adenylate cyclase activity.
1907	involved in the conversion of lanosterol to cholesterol.
1908	
1909	may be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. might also have a role in the development and maturation of lymphoid cells.
1910	mediates the endocytosis of glycoproteins by macrophages. binds both sulfated and non-sulfated polysaccharide chains. acts as phagocytic receptor for bacteria, fungi and other pathogens.
1911	
1912	
1913	delivers copper to copper zinc superoxide dismutase (sod1).
1914	
1915	catalyzes the formation of l-carnitine from gamma- butyrobetaine.
1916	
1917	transcription factor.
1918	
1919	thought to form a receptor-activated non-selective calcium permeant cation channel. probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or g-protein coupled receptors. activated by diacylglycerol (dag) in a membrane-delimited fashion, independently of protein kinase c. seems not to be activated by intracellular calcium store depletion.
1920	
1921	may play a role in organizing the actin cytoskeleton of the brain cells.
1922	
1923	involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin.
1924	catalyzes the n-methylation of nicotinamide and other pyridines to form pyridinium ions. this activity is important for biotransformation of many drugs and xenobiotic compounds.
1925	
1926	probable protease. seems to be capable of activating enac (by similarity).
1927	may play a role in vesicular transport from endoplasmic reticulum to golgi.
1928	displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols.
1929	
1930	
1931	initiates the extrinsic pathway of blood coagulation. serine protease that circulates in the blood in a zymogen form. factor vii is converted to factor viia by factor xa, factor xiia, factor ixa, or thrombin by minor proteolysis. in the presence of tissue factor and calcium ions, factor viia then converts factor x to factor xa by limited proteolysis. factor viia will also convert factor ix to factor ixa in the presence of tissue factor and calcium (by similarity).
1932	the paf1 complex is a multifunctional complex. involved in transcription initiation via genetic interactions with tata- binding proteins. involved in elongation. it regulates 3@#$%&end formation of snr47 by modulating the recruitment or stable association of nrd1 and nab3 with rna polymerase ii. also has a role in transcription-coupled histone modification. required for activation of rad6 ubiquitin conjugate and the bre1 ubiquitin ligase which ubiquitylate lys-126 histone h2b. activates the set1 histone methyltransferase complex for methylation of lys-4 of histone h3 and for methylation of lys-73 of histone h3 by dot1 and lys-36 of histone h3 by set2. in complex with paf1, required for normal cln1 and cln2 g1 cyclin expression in late g1. also has a role in chromosome segregation where it appears to be involved in microtubule placement.
1933	
1934	
1935	
1936	
1937	may bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. may be under transcriptional regulation of steroid hormones.
1938	may be required for neuronal cell differentiation.
1939	may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (by similarity).
1940	
1941	
1942	troponin t is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin atpase activity.
1943	positively regulates the wnt signaling pathway by stabilizing beta-catenin through the association with gsk-3.
1944	component of the tim22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. the tim22 complex forms a twin- pore translocase that uses the membrane potential as external driving force. in the tim22 complex, it may act as a docking point for the soluble 70 kda complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.
1945	resistance to tetracycline by an active tetracycline efflux. this is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. this protein functions as a metal-tetracycline/h(+) antiporter.
1946	
1947	
1948	component of the bactericidal ra-reactive factor rarf which specifically binds to ra and r2 polysaccharides expressed by certain enterobacteria. it triggers the activation of complement cascade by activating the c4 and c2 components. it activates the c4 component by cleaving the alpha-chain of c4.
1949	
1950	may act as a negative regulator of entry into mitosis (g2 to m transition) by protecting the nucleus from cytoplasmically activated cyclin b1-complexed cdc2 before the onset of mitosis. its activity increases during s and g2 phases and decreases at m phase when it is hyperphosphorylated. a correlated decrease in protein level occurs at m/g1 phase, probably due to its degradation. specifically phosphorylates and inactivates cyclin b1-complexed cdc2 reaching a maximum during g2 phase and a minimum as cells enter m phase. phosphorylation of cyclin b1-cdc2 occurs exclusively on tyr-15 and phosphorylation of monomeric cdc2 does not occur.
1951	am and pamp are potent hypotensive and vasodilatator agents. numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. in the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. in pituitary gland, both peptides at physiologically relevant doses inhibit basal acth secretion. both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
1952	
1953	cleaves c-terminal amino acids linked to proline in peptides such as angiotensin ii, iii and des-arg9-bradykinin. this cleavage occurs at acidic ph, but enzymatic activity is retained with some substrates at neutral ph.
1954	the interaction with sm proteins inhibits their assembly on u rna and interferes with snrnp biogenesis. inhibits the binding of survival motor neuron protein (smn) to sm proteins. may participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.
1955	
1956	putative odorant receptor.
1957	
1958	may be involved in transcriptional regulation.
1959	
1960	
1961	integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. during myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. it is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. isoform alpha-7x2b and isoform alpha-7x1b promote myoblast migration on laminin 1 and laminin 2/4, but isoform alpha-7x1b is less active on laminin 1 (in vitro).
1962	
1963	enhances ar-mediated transactivation. transactivation decreases as the poly-gln length within ar increases.
1964	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
1965	
1966	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
1967	
1968	
1969	
1970	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
1971	
1972	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. socs2 appears to be a negative regulator in the growth hormone/igf1 signaling pathway.
1973	orphan nuclear receptor.
1974	
1975	
1976	
1977	
1978	this protein is essential for differentiation. it may play a role in localizing of nanos (a maternal determinant) activity in oocytes. bicd mutations cause nanos mislocalization and thus bicaudal development.
1979	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of calcium out of the cell.
1980	sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. controls the reabsorption of sodium in kidney, colon, lung and sweat glands. also plays a role in taste perception.
1981	parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.
1982	required for protein transport from the er to the golgi complex.
1983	
1984	component of unactivated mammalian steroid receptor complexes that sediment at 8-10 s. may have a rotamase activity. may play a role in the intracellular trafficking of hetero- oligomeric forms of steroid hormone receptors.
1985	
1986	
1987	has e3 ubiquitin protein ligase activity. regulates the levels of casp8 and casp10 by targeting them for proteasomal degradation. protects cells against apoptosis induced by tnf. binds phosphatidylinositol-5-phosphate and phosphatidylinositol-3- phosphate.
1988	
1989	
1990	probable protein kinase whose role is not yet known. may play a role in the phosphorylation of proteins central to parkinson disease. may also have gtpase activity.
1991	
1992	
1993	
1994	
1995	
1996	
1997	does not possess sterol isomerase activity and does not bind sigma ligands (by similarity).
1998	
1999	
2000	component of the sin3-repressing complex. enhances the ability of sin3-hdac1-mediated transcriptional repression. when tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins.
2001	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
2002	
2003	proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. may constitute a major route for the absorption of protein digestion end-products.
2004	
2005	
2006	
2007	may function in chaperone-mediated protein folding.
2008	may function as an antagonist of fibroblast growth factor (fgf) pathways and may negatively modulate respiratory organogenesis.
2009	cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. dynein has atpase activity; the force-producing power stroke is thought to occur on release of adp.
2010	may play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. extrahepatic arginase functions to regulate l-arginine bioavailability to no synthase. since no synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase ii plays a role in both male and female sexual arousal. it is therefore a potential target for the treatment of male and female sexual arousal disorders.
2011	may have a role in the cell cycle.
2012	involved in the biogenesis of the 60s ribosomal subunit (by similarity).
2013	receptor for bradykinin. it is associated with g proteins that activate a phosphatidylinositol-calcium second messenger system.
2014	inhibits factor xa activity in the presence of protein z, calcium and phospholipid.
2015	
2016	receptor for extracellular adenine nucleotides such as atp and adp. in pancreatic islets, may mediate some of the effects of extracellular atp on insulin secretion.
2017	
2018	
2019	specifically phosphorylates the activated forms of g protein-coupled receptors.
2020	
2021	
2022	
2023	
2024	
2025	galactose-specific lectin which binds ige. may mediate with the alpha-3, beta-1 integrin the stimulation by cspg4 of endothelial cells migration.
2026	
2027	
2028	required for membrane traffic to the vacuole.
2029	dna repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. may be involved in interstrand dna cross-link repair and in the maintenance of normal chromosome stability.
2030	functions as a negative regulator of ap-1 mediated transcription by binding to jun proteins. jun/b-atf heterodimers bind dna preferentially at the 12-o-tetradecanoylphorbol-13- acetate response element (tre) (consensus: 5@#$%&-tga[cg]tca-3@#$%&) and weaker at the camp responsive region (cre) (consensus: 5@#$%&- gtgacgt[ac][ag]-3@#$%&), but are transcriptionally inert.
2031	binds with high affinity to rna molecules that contain au-rich elements (ares) found within the 3@#$%& untranslated regions of many protooncogenes and cytokine mrnas. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain (by similarity).
2032	this enzyme is probably necessary for target cell lysis in cell-mediated immune responses.
2033	
2034	interacts with key regulators (cbp, p300 and pcaf) of transcription and represses transcription. acts as a histone- binding protein that regulates transcription. acts as a deubiquitinating enzyme.
2035	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
2036	hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. involved in cell proliferation. probably regulates the stability of stam2 and rasgrf1. required to enter into s phase in response to serum stimulation. may regulate t-cell anergy mediated by rnf128 via the formation of a complex containing rnf128 and stam2.
2037	
2038	regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. confers calcium sensitivity.
2039	beta-hexosaminidase a is responsible for the degradation of gm2 gangliosides, and a variety of other molecules containing terminal n-acetyl hexosamines, in the brain and other tissues. the form b is active against certain oligosaccharides. the form s has no measurable activity.
2040	
2041	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
2042	
2043	
2044	could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. regulates the ph of melanosome and the melanosome maturation. one of the components of the mammalian pigmentary system. seems to regulate the postranslational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. may serve as a key control point at which ethnic skin color variation is determined. major determinant of brown and/or blue eye color.
2045	
2046	catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
2047	
2048	
2049	
2050	plays a role in intermediary metabolism and energy production. it may tightly associate or interact with the pyruvate dehydrogenase complex.
2051	
2052	
2053	
2054	
2055	co-chaperone of hsc70. seems to play a role in protein import into mitochondria.
2056	mediates iodide uptake in the thyroid gland.
2057	catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. contributes to the formation of the cornified cell envelope of keratinocytes.
2058	
2059	
2060	
2061	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
2062	
2063	
2064	in the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, nonnucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.
2065	
2066	
2067	
2068	involved in ph regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. major proton extruding system driven by the inward sodium ion chemical gradient. plays an important role in signal transduction (by similarity).
2069	
2070	
2071	
2072	
2073	
2074	
2075	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. this cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. it associates with alpha-catenin forming a link to the cytoskeleton.
2076	
2077	
2078	soluble il4r (sil4r) inhibits il4-mediated cell proliferation and il5 up-regulation by t-cells.
2079	
2080	
2081	could regulate proteolytic events associated with testicular germ cell maturation.
2082	atp-dependent rna helicase involved in mrna export from the nucleus (by similarity).
2083	component of the cleavage factor im (cfim) complex that plays a key role in pre-mrna 3@#$%& processing. involved in association with cpsf6 in pre-mrna 3@#$%&-end poly(a) site cleavage and poly(a) addition. nudt21/cpsf5 binds to cleavage and polyadenylation rna substrates.
2084	binds heavy metals. contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. inhibits survival and neurite formation of cortical neurons in vitro.
2085	may catalyze alpha-1,3 glycosidic linkages involved in the expression of lewis x/ssea-1 and vim-2 antigens.
2086	may be involved in transcriptional regulation.
2087	
2088	functions in segment determination through interaction with genes of bithorax (bx-c) and antennapedia (ant-c) complexes. it can behave as an activator of bx-c. involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. shown to bind zinc (in vitro).
2089	the gpib-v-ix complex functions as the von willebrand factor receptor and mediates von willebrand factor-dependent platelet adhesion to blood vessels. the adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis (by similarity).
2090	
2091	
2092	
2093	
2094	
2095	transcriptional activator that binds to the sterol regulatory element 1 (sre-1) (5@#$%&-atcaccccac-3@#$%&). has dual sequence specificity, binding to both an e-box motif (5@#$%&-atcacgtga-3@#$%&) and to sre-1 (5@#$%&-atcaccccac-3@#$%&). regulates the transcription of genes for sterol biosynthesis and the ldl receptor gene.
2096	probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. can be blocked by extracellular barium and cesium.
2097	
2098	
2099	
2100	reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. involved in intracellular redox signaling.
2101	catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length.
2102	
2103	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
2104	
2105	
2106	this protein shows activity both toward tyrosine-protein phosphate as well as with serine-protein phosphate.
2107	acetyltransferase enzyme. acetylates histones, giving a specific tag for transcriptional activation. also acetylates non- histone proteins, like ncoa3 coactivator. mediates camp-gene regulation by binding specifically to phosphorylated creb protein. cbp, as coactivator, augments the activity of phosphorylated creb to activate transcription of camp-responsive genes (by similarity).
2108	neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. a broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. orexin-a binds to both ox1r and ox2r with a high affinity, whereas orexin-b binds only to ox2r with a similar high affinity.
2109	
2110	involved in nucleolar processing of pre-18s ribosomal rna (by similarity).
2111	
2112	prohibitin inhibits dna synthesis. it has a role in regulating proliferation. as yet it is unclear if the protein or the mrna exhibits this effect. may play a role in regulating mitochondrial respiration activity and in aging.
2113	
2114	
2115	
2116	
2117	
2118	
2119	acts as a sequence-specific transcriptional repressor in association with bcl6. may function in a narrow stage or be related to some events in the early b-cell development.
2120	appears to have a function in striated muscle development and regeneration.
2121	
2122	collagen type iii occurs in most soft connective tissues along with type i collagen.
2123	may be involved in mitogenic function of fgf1.
2124	likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
2125	
2126	
2127	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
2128	probably plays a specific functional role in the rods and/or cones of photoreceptors. it may be the enzyme involved in the resynthesis of cgmp required for recovery of the dark state after phototransduction.
2129	
2130	essential role in pre-mrna splicing.
2131	may have a specific function in the mechanism or regulation of t-cell cytolytic activity.
2132	functions as an e3-type small ubiquitin-like modifier (sumo) ligase, stabilizing the interaction between ube2i and the substrate, and as a sumo-tethering factor. plays a crucial role as a transcriptional coregulator in various cellular pathways, including the stat pathway, the p53 pathway and the steroid hormone signaling pathway. the effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the pias2 isoform studied. however, it seems to be mostly involved in gene silencing. binds to sumoylated elk1 and enhances its transcriptional activity by preventing recruitment of hdac2 by elk1, thus reversing sumo-mediated repression of elk1 transactivation activity. isoform pias2-beta, but not isoform pias2-alpha, promotes mdm2 sumoylation. isoform pias2-beta promotes ncoa2 sumoylation more efficiently than isoform pias2-alpha.
2133	
2134	thyroid hormone-binding protein. probably transports thyroxine from the bloodstream to the brain.
2135	
2136	
2137	involved in the morphogenesis of the adult appendages. gtpase-activating protein for p21-rac. promotes the exchange of rac-bound gdp by gtp.
2138	
2139	tumor-associated antigen.
2140	
2141	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. component of the flavoprotein-sulfur (fp) fragment of the enzyme.
2142	protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. necessary for apoptotic membrane blebbing. plays a role in smooth muscle contraction. required for centromere positioning and centromere- dependent exit from mitosis (by similarity).
2143	may be one regulator of transcriptional events during hemopoietic development.
2144	may be involved in transcriptional regulation.
2145	in the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (krtap), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. the matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
2146	may be involved in transcriptional regulation.
2147	
2148	may be involved in transcriptional regulation.
2149	co-chaperone that binds to numerous kinases and promotes their interaction with the hsp90 complex, resulting in stabilization and promotion of their activity.
2150	adhesion molecule that binds to leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2). binds to alpha-4/beta-1 and alpha-v integrins.
2151	
2152	
2153	
2154	
2155	calcium-dependent mitochondrial solute carrier (by similarity).
2156	involved in the protein trafficking from the golgi apparatus to the plasma membrane (by similarity).
2157	
2158	
2159	
2160	
2161	
2162	
2163	
2164	transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions (by similarity).
2165	formation of pseudouridine at position 38 and 39 in the anticodon stem and loop of transfer rnas (by similarity).
2166	most effectively accelerate the intrinsic gtpase activity of ypt7. it is also active, but to a lesser extent, on ypt31, ypt32 and ypt1. ypt6 and sec4.
2167	terminates the action of serotonine by its high affinity sodium-dependent reuptake into presynaptic terminals.
2168	
2169	this transcriptional activator recognizes and binds to the sequence 5@#$%&-rttaygtaay-3@#$%& found in the promoter of genes such as albumin, cyp2a4 and cyp2a5. it is not essential for circadian rhythm generation, but modulates important clock output genes. may be a direct target for regulation by the circadian pacemaker component clock. may affect circadian period and sleep regulation.
2170	this transcriptional activator recognizes and binds to the sequence 5@#$%&-rttaygtaay-3@#$%& found in the promoter of genes such as albumin, cyp2a4 and cyp2a5. it is not essential for circadian rhythm generation, but modulates important clock output genes. may be a direct target for regulation by the circadian pacemaker component clock. may affect circadian period and sleep regulation.
2171	probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. can be blocked by extracellular barium and cesium.
2172	
2173	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
2174	
2175	
2176	cleaves peptide substrates after methionine, leucine, and norleucine.
2177	
2178	
2179	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
2180	
2181	may antagonize nodal signaling and subsequent organization of axial structures during mesodermal patterning (by similarity).
2182	
2183	can degrade fibronectin, gelatins of type i, iii, iv, and v; weakly collagens iii, iv, and v. activates procollagenase.
2184	
2185	modifies the functions of natural killer cells, monocytes and granulocytes. inhibits c5a-dependent neutrophil enzyme release and chemotaxis.
2186	
2187	
2188	
2189	involved in the activation cascade of caspases responsible for apoptosis execution (by similarity).
2190	
2191	transcription factor required for gene expression specific to photoreceptor cells.
2192	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. utilizes a wide range of saturated fatty acids with a preference for c16-c18 unsaturated fatty acids (by similarity).
2193	may be responsible for the production of 19r- hydroxyprostaglandins which are major components of human seminal fluid.
2194	
2195	type i collagen is a member of group i collagen (fibrillar forming collagen).
2196	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
2197	involved in translocation of long-chain fatty acids (lfca) across the plasma membrane. the lfca import appears to be hormone-regulated in a tissue-specific manner. in adipocytes, but not myocytes, insulin induces a rapid translocation of fatp1 from intracellular compartments to the plasma membrane, paralleled by increased lfca uptake. may act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. plays a pivotal role in regulating available lfca substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. may be involved in regulation of cholesterol metabolism. has acyl-coa ligase activity for long-chain and very-long-chain fatty acids.
2198	recognizes and binds the palindromic sequence 5@#$%&- ttggcnnnnngccaa-3@#$%& present in viral and cellular promoters and in the origin of replication of adenovirus type 2. these proteins are individually capable of activating transcription and replication.
2199	
2200	component of the origin recognition complex (orc) that binds origins of replication. it has a role in both chromosomal replication and mating type transcriptional silencing. binds to the ars consensus sequence (acs) of origins of replication in an atp-dependent manner.
2201	may act as a transcription factor for cell pluripotency and differentiation in the embryo.
2202	transcriptional repressor of genes that require a bhlh protein for their transcription. may act as a negative regulator of myogenesis by inhibiting the functions of myod1 and ash1 (by similarity).
2203	
2204	crystallins are the dominant structural components of the vertebrate eye lens.
2205	
2206	
2207	
2208	essential for recycling gmp and indirectly, cgmp.
2209	part of a post-splicing multiprotein complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity (by similarity).
2210	catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. has also a vitamin d3- 25-hydroxylase activity.
2211	
2212	
2213	
2214	this is the largest subunit of complex i and it is a component of the iron-sulfur (ip) fragment of the enzyme. it may form part of the active site crevice where nadh is oxidized.
2215	this is the largest subunit of complex i and it is a component of the iron-sulfur (ip) fragment of the enzyme. it may form part of the active site crevice where nadh is oxidized.
2216	this protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
2217	
2218	
2219	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
2220	appears to play a role in cell sterol metabolism. it may function to protect cells from over-accumulation of cholesterol.
2221	
2222	acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (by similarity). causes reduced proliferation of b-lymphocytes.
2223	
2224	
2225	
2226	catalyzes the posttranslational addition of a tyrosine to the c-terminal end of detyrosinated alpha-tubulin.
2227	
2228	
2229	orphan receptor. may play a role in brain function.
2230	
2231	
2232	
2233	
2234	putative rna helicase involved in the second step of rna splicing. may promote one or more conformational changes in the dynamic network of rna-rna interactions in the spliceosome. appears to catalyze an atp-dependent unwinding of u4/u6 rna duplices.
2235	
2236	involved in gpi-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of gpi (by similarity).
2237	involved in transport factor (ran-gtp, karyopherin)- mediated protein import via the f-g repeat-containing domain which acts as a docking site for substrates. could also have isomerase or chaperone activity and may bind rna or dna. component of the nuclear export pathway. specific docking site for the nuclear export factor exportin-1.
2238	orphan receptor.
2239	
2240	
2241	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
2242	may be involved in retrograde transport from early and late endosomes to late golgi (by similarity).
2243	attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to na-k atpase, to the lymphocyte membrane protein gp85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. in skeletal muscle, isoform mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
2244	
2245	may be involved in transcriptional regulation.
2246	
2247	
2248	the cytotoxic action of bpi is limited to many species of gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic n-terminal half for the negatively charged lipopolysaccharides that are unique to the gram-negative bacterial outer envelope.
2249	the cytotoxic action of bpi is limited to many species of gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic n-terminal half for the negatively charged lipopolysaccharides that are unique to the gram-negative bacterial outer envelope.
2250	protein kinase that plays an important role in cellular stress response. activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic foxo3a. phosphorylates nedd4l, which leads to its inactivation and to the subsequent activation of various channels and transporters such as enac, kv1.3, or eaat1.
2251	shown to enhance tdt activity, in vitro.
2252	troponin is the central regulatory protein of striated muscle contraction. tn consists of three components: tn-i which is the inhibitor of actomyosin atpase, tn-t which contains the binding site for tropomyosin and tn-c. the binding of calcium to tn-c abolishes the inhibitory action of tn on actin filaments.
2253	glycosyltransferase required for the biosynthesis of heparan-sulfate. the ext1/ext2 complex possesses substantially higher glycosyltransferase activity than ext1 or ext2 alone. appears to be a tumor suppressor.
2254	
2255	seems to be involved in embryonic mesoderm formation. binds to 3 e-boxes of the e-cadherin gene promoter and represses its transcription.
2256	
2257	
2258	
2259	may play a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. there are four molecules of fkbp12 per skeletal muscle ryr. ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
2260	
2261	
2262	
2263	may be involved in several stages of intracellular trafficking.
2264	
2265	may play a role in chondrocyte differentiation and may also influence cervix development.
2266	
2267	may be involved in the airway inflammatory response after exposure to irritants. may be associated with tumor progression. may play a role in innate immune responses of the upper airways.
2268	
2269	
2270	
2271	
2272	
2273	transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. potential role in g2/m cell cycle regulation (by similarity).
2274	
2275	
2276	may contribute to the transparency and refractive index of the lens.
2277	can efficiently cleave only isg15 fusions including native isg15 conjugates linked via isopeptide bonds. necessary to maintain a critical cellular balance of isg15-conjugated proteins in both healthy and stressed organisms.
2278	
2279	
2280	
2281	
2282	may regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-er compartment.
2283	catalyzes the o-sulfation of tyrosine residues within acidic motifs of polypeptides.
2284	
2285	
2286	may play a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.
2287	recognizes and binds the 7-methylguanosine-containing mrna cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mrnas secondary structures.
2288	
2289	transfer of a sulfur ion to cyanide or to other thiol compounds. also has weak rhodanese activity. may have a role in cyanide degradation or in thiosulfate biosynthesis.
2290	plays a role in protein sorting and trafficking between the trans-golgi network (tgn) and endosomes. mediates the arf- dependent recruitment of clathrin to the tgn and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (ac-ll) motif.
2291	
2292	lacks cytidine deaminase activity, at least on rna molecules (monomeric nucleoside substrates or synthetic apob, nf1 and nat1 rna template). binds to apob and au-rich rnas. unable to reduce hiv-1 infectivity in vitro.
2293	
2294	
2295	
2296	
2297	
2298	acts as a copper chaperone, transporting copper to the cu(a) site on the cytochrome c oxidase subunit ii (cox2).
2299	has a dehydrogenase activity on palmitoyl-coa (c16:0) and stearoyl-coa (c18:0). it is three times more active on palmitoyl-coa then on stearoyl-coa. has little activity on octanoyl-coa (c8:0), butyryl-coa (c4:0) or isovaleryl-coa (5:0).
2300	
2301	
2302	
2303	necessary for efficient rna polymerase ii transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by s-ii allows the resumption of elongation from the new 3@#$%&terminus.
2304	
2305	electroneutral sodium- and bicarbonate-dependent cotransporter with a na(+):hco3(-) 1:1 stoichiometry. regulates intracellular ph and may play a role in bicarbonate salvage in secretory epithelia. may also have an associated sodium channel activity.
2306	fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-coa, malonyl-coa and nadph. this multifunctional protein has 7 catalytic activities and an acyl carrier protein.
2307	
2308	regulatory subunit of the pi3k complex. may regulate membrane trafficking late in the endocytic pathway.
2309	
2310	
2311	may act as a specific coactivator for the mammalian tefs (by similarity).
2312	
2313	involved in the ubiquitination and subsequent proteasomal degradation via the von hippel-lindau ubiquitination complex. seems to act as target recruitment subunit in the e3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (hif) under normoxic conditions. involved in transcriptional repression through interaction with hif1a, hif1an and histone deacetylases.
2314	receptor for oxytocin. the activity of this receptor is mediated by g proteins which activate a phosphatidylinositol- calcium second messenger system.
2315	arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
2316	
2317	
2318	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. this protein may mediate formation of the complex between cytochromes c and c1.
2319	
2320	inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (by similarity).
2321	
2322	
2323	
2324	rna-binding protein. binds poly(g) and poly(u) but not poly(a) or poly(c). regulates somite formation, probably by regulating gene expression (by similarity).
2325	
2326	essential subunit of n-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an asn-x-ser/thr consensus motif in nascent polypeptide chains.
2327	acts as a microtubule-associated protein which interacts with cytoplasmic microtubules through beta-tubulin.
2328	
2329	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
2330	
2331	
2332	
2333	
2334	
2335	
2336	
2337	microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (by similarity).
2338	
2339	isoform 1 transcriptionally activates the lyn and blk promoters and acts synergistically with runx1 to transactivate the blk promoter. isoform 2 may function in repression of runx1- mediated transactivation.
2340	ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. this enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the c-terminal glycine of ubiquitin. also binds to free monoubiquitin and may prevent its degradation in lysosomes. the homodimer may have atp-independent ubiquitin ligase activity.
2341	
2342	
2343	
2344	attaches integral membrane proteins to cytoskeletal elements. also binds to cytoskeletal proteins. required for coordinate assembly of na/ca exchanger, na/k atpase and insp3 receptor at sarcoplasmic reticulum sites in cardiomyocytes.
2345	
2346	guanine nucleotide exchange factor (gef) for rap1a, rap1b and rap2b gtpases. does not interact with camp or cgmp.
2347	
2348	
2349	required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. stimulates dmc1-dependent homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
2350	phosphorylates eukaryotic elongation factor-2. binds calmodulin (by similarity).
2351	replaces conventional h2a in a subset of nucleosomes. may be involved in the formation of constitutive heterochromatin. may be required for chromosome segregation during cell division.
2352	could be involved in the induction of mineralization of extracellular matrix.
2353	
2354	hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin a.
2355	
2356	not known. may bind to chromatin.
2357	this enzyme condenses acetyl-coa with acetoacetyl-coa to form hmg-coa, which is the substrate for hmg-coa reductase.
2358	
2359	
2360	protein transport. probably involved with ras-related protein rab-3a in synaptic vesicle traffic and/or synaptic vesicle fusion. could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
2361	may be involved in transcriptional regulation. plays a role during development and organogenesis as well as in the function of the adult central nervous system (by similarity).
2362	
2363	appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. phosphorylation of dmd or utrn may modulate their affinities for associated proteins. functions in a multi-protein complex in spermatid maturation. regulates lipopolysaccharide-induced il-12 synthesis in macrophages by forming a complex with traf6, resulting in the inhibition of traf6 nf-kappab activation (by similarity).
2364	
2365	involved in gpi-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of gpi (by similarity).
2366	transcription factor that binds rna polymerase ii and inhibits the elongation of transcripts from target promoters. regulates transcription elongation in a tata box-dependent manner. necessary for tat-dependent activation of the human immunodeficiency virus type 1 (hiv-1) promoter.
2367	
2368	
2369	
2370	cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
2371	
2372	
2373	
2374	probably plays a role in anchoring the complex to other cellular components.
2375	this enzyme is necessary for target cell lysis in cell- mediated immune responses. it cleaves after lys or arg. may be involved in apoptosis.
2376	
2377	
2378	protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
2379	docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. dok3 is a negative regulator of jnk signaling in b-cells through interaction with inpp5d/ship. may modulate abl function (by similarity).
2380	signal-transducing molecule. may have a common pathway with il6st. the soluble form inhibits the biological activity of lif by blocking its binding to receptors on target cells.
2381	may play a role in the regulation of ionic transport. binds calcium.
2382	this protein is a component of ribonucleosomes.
2383	directs the termination of nascent peptide synthesis (translation) in response to the termination codons uaa, uag and uga.
2384	cyclin-dependent kinases (cdks) are activated by the binding to a cyclin and mediate the progression through the cell cycle. each different complex controls a specific transition between two subsequent phases in the cell cycle. cdk7 is the catalytic subunit of the cdk-activating kinase (cak) complex, a serine-threonine kinase. cak activates the cyclin-associated kinases cdc2/cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation. cak complexed to the core-tfiih basal transcription factor activates rna polymerase ii by serine phosphorylation of the repetitive c-terminus domain (ctd) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts. involved in cell cycle control and in rna transcription by rna polymerase ii. its expression and activity are constant throughout the cell cycle.
2385	mediates endoplasmic reticulum to golgi transport (by similarity).
2386	downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small gtpases to the actin cytoskeleton.
2387	electrically silent transporter system. mediates sodium and chloride reabsorption. plays a vital role in the regulation of ionic balance and cell volume.
2388	component of the anaphase promoting complex/cyclosome (apc/c), a cell cycle-regulated e3 ubiquitin-protein ligase complex that controls progression through mitosis and the g1 phase of the cell cycle. the apc/c is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating e2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26s proteasome. in early mitosis, the apc/c is activated by cdc20 and targets securin pds1, the b-type cyclin clb5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. in late mitosis and in g1, degradation of clb5 allows activation of the apc/c by cdh1, which is needed to destroy cdc20 and the b-type cyclin clb2 to allow exit from mitosis and creating the low cdk state necessary for cytokinesis and for reforming prereplicative complexes in g1 prior to another round of replication.
2389	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins that stimulate adenylate cyclase.
2390	calcium-binding protein. may have a role in calcium homeostasis.
2391	
2392	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
2393	
2394	mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). it is sensitive (es) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (nbmpr) and is sodium-independent. it has a higher affinity for adenosine. inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
2395	may be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides (by similarity).
2396	
2397	cleaves peptide bonds on the c-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
2398	
2399	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
2400	
2401	
2402	not known. the authors believe that it may be involved in transmembrane signal transduction through a postulated calcium- binding function, but the evidence for the existence of a calcium- binding region is weak.
2403	
2404	could be a global transcriptional regulator. modifies gene expression by affecting chromatin (potential).
2405	may be involved in transcriptional regulation.
2406	minor component of the myelin sheath. may be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication.
2407	
2408	
2409	component c2 which is part of the classical pathway of the complement system is cleaved by activated factor c1 into two fragments: c2b and c2a. c2a, a serine protease, then combines with complement factor 4b to generate the c3 or c5 convertase.
2410	
2411	
2412	
2413	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (by similarity).
2414	has a role in the negative regulation of gluconeogenesis. required for proteosome-dependent catabolite degradation of fructose-1,6-bisphosphatase (fbpase). accelerates proteosomal breakdown of ubiquitinated proteins as it disassembles free ubiquitin chains that would compete with ubiquitinated proteins to bind to the proteosome.
2415	receptor for tnfsf6/faslg. the adapter molecule fadd recruits caspase-8 to the activated receptor. the resulting death- inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. fas- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature t-cells, or both. the secreted isoforms 2 to 6 block apoptosis (in vitro).
2416	
2417	probable transcriptional regulator involved in developmental processes.
2418	
2419	
2420	
2421	
2422	
2423	component of a protein kinase signal transduction cascade. phosphorylates and activates map2k4 and map2k6, which in turn activate the jnk and p38 map kinases, respectively. overexpression induces apoptotic cell death.
2424	b-fabp could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during cns development. it is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (by similarity).
2425	may be involved in bmp2-induced transcription (by similarity).
2426	assembly of polyisoprenoid side chains. the polyprenyl synthetase of coenzyme q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species.
2427	destroys radicals which are normally produced within the cells and which are toxic to biological systems.
2428	
2429	
2430	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
2431	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
2432	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
2433	may play an important role in the regulation of lymphoma cell growth. interacts with a 16-kda leu-13 protein to form a complex possibly involved in signal transduction. may acts a the viral receptor for hcv.
2434	component of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends.
2435	
2436	involved in intracellular signal transduction mediated by cytokines and growth factors. upon il-2 and gm-csl stimulation, it plays a role in signaling leading to dna synthesis and c-myc induction. may also play a role in endocytic trafficking as well as in t-cell development.
2437	
2438	activates e box-dependent transcription in collaboration with tcf3/e47. may be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. transactivates the promoter of its own gene.
2439	may be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.
2440	transcriptional activator that binds to dna sequences containing the consensus pentanucleotide 5@#$%&-cgga[at]-3@#$%&.
2441	
2442	
2443	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
2444	
2445	
2446	could be a melanogenic enzyme (by similarity).
2447	
2448	
2449	cleaves presequences (transit peptides) from mitochondrial protein precursors (by similarity).
2450	
2451	
2452	
2453	
2454	
2455	accessory protein for the calcitonin gene-related peptide (cgrp) receptor. it modulates cgrp responsiveness in a variety of tissues.
2456	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity).
2457	required for normal golgi function (by similarity).
2458	collagen type iv is specific for basement membranes.
2459	
2460	may have a role in germline development.
2461	
2462	
2463	
2464	
2465	
2466	endoribonuclease responsible for the inhibition of the translation by cleaving mrna. inhibits cell-free protein synthesis. cleaves phosphodiester bonds only in single-stranded rna (by similarity).
2467	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. binds poly(rg).
2468	mediates the sorting and transport of syntaxin-cargo vesicles along microtubules in neuronal processes. tne syntabulin- syntaxin interaction is required for syntaxin-cargo vesicles transport.
2469	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
2470	may function as a transcriptional activator protein and may play a key role in the organogenesis of the fat body. binds a sequence element (5@#$%&-[ta]gataa-3@#$%&) found in the larval promoters of all known alcohol dehydrogenase (adh) genes. acts as a homeotic gene downstream of the terminal gap gene hkb to promote morphogenesis and differentiation of anterior and posterior midgut.
2471	may be involved in cell-cell adhesion and signal transduction.
2472	
2473	
2474	couples the p55 tnf-receptor (tnf-r55 / tnfr1) to neutral sphingomyelinase (n-smase). specifically binds to the n- smase activation domain of tnf-r55. may regulate ceramide production by n-smase.
2475	
2476	
2477	involved in control of the cell cycle. upon lytic infection of permissive cells, the hsv transactivator protein vp16 associates with hcfc1. binding to hcfc1 activates vp16 for association with the octamer motif-binding protein pou2f1, to form a multiprotein-dna complex responsible for activating transcription of the hsv immediate early genes. also antagonizes transactivation by zbtb17 and gabp2; represses zbtb17 activation of the p15(ink4b) promoter and inhibits its ability to recruit p300. coactivator for egr2 and gabp2. tethers the chromatin modifying set1/ash2 histone h3-k4 methyltrasferase (hmt) and sin3 histone deacetylase (hdac) complexes (involved in the activation and repression of transcription, respectively) together.
2478	
2479	docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. dok2 may modulate the cellular proliferation induced by il-4, as well as il-2 and il-3. may be involved in modulating bcr-abl signaling. attenuates egf- stimulated map kinase activation (by similarity).
2480	
2481	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
2482	hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. may play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
2483	
2484	induces apoptosis. interacts with viral and cellular anti-apoptosis proteins. can overcome the suppressors bcl-2 and bcl-xl, although high levels of bcl-xl expression will inhibit apoptosis. may function as a tumor suppressor.
2485	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
2486	
2487	
2488	promotes the exchange of cdc42-bound gdp by gtp. controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. cdc24 may be involved in the initial selection and organization of the budding site.
2489	probably involved in the control of the cell cycle. interacts with cyclins a, b3, d, or e. activity of cdk2 is maximal during s phase and g2.
2490	
2491	
2492	
2493	
2494	
2495	
2496	
2497	plays an important role in the regulation of specific inflammatory disease processes (by similarity).
2498	converts udp and glcnac-1-p into udp-glcnac, and udp and galnac-1-p into udp-galnac. isoform agx1 has 2 to 3 times higher activity towards galnac-1-p, while isoform agx2 has 8 times more activity towards glcnac-1-p.
2499	stimulates the dissociation of gdp from the ras-related rala and ralb gtpases which allows gtp binding and activation of the gtpases. interacts and acts as an effector molecule for r-ras, h-ras, k-ras, and rap.
2500	orphan receptor.
2501	
2502	transcriptional corepressor that binds to a number of transcription factors. inhibits nf-kappa-b-regulated gene expression. inhibits the transcriptional activation mediated by foxa2, and by ctnnb1 and tcf family members in wnt signaling. the effects of full-length tle family members may be modulated by association with dominant-negative aes. unusual function as coactivator for esrrg.
2503	
2504	chemotactic factor that attracts skin-associated memory t-lymphocytes. may play a role in mediating homing of lymphocytes to cutaneous sites. binds to ccr10.
2505	the cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
2506	microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. most probably involved in vesicular trafficking processes, in particular endocytosis.
2507	aldhs play a major role in the detoxification of alcohol-derived acetaldehyde. they are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
2508	may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with gtp-binding proteins. essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. can interact with syntaxins 1, 2, and 3 but not syntaxin 4. may play a role in determining the specificity of intracellular fusion reactions.
2509	
2510	necessary for protein translocation in the endoplasmic reticulum.
2511	
2512	
2513	
2514	
2515	
2516	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
2517	
2518	putative atp-dependent protease.
2519	
2520	activates cdc42, a member of the ras-like family of rho- and rac proteins, by exchanging bound gdp for free gtp. plays a role in regulating the actin cytoskeleton and cell shape.
2521	dorsalizing factor. key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing tgf-beta family bone morphogenetic proteins (bmps) and sequestering them in latent complexes (by similarity).
2522	
2523	chloride channel or a regulator or accessory subunit of other proteins that could provide the pore-froming function.
2524	chloride channel or a regulator or accessory subunit of other proteins that could provide the pore-froming function.
2525	adds the second glucose residue to the lipid-linked oligosaccharide precursor for n-linked glycosylation. transfers glucose from dolichyl phosphate glucose (dol-p-glc) onto the lipid-linked oligosaccharide glc(1)man(9)glcnac(2)-pp-dol (by similarity).
2526	involved in pyrimidine base degradation. catalyzes the reduction of uracil and thymine. also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
2527	
2528	may be involved in both signal transduction and cellular adhesion in the cns.
2529	
2530	
2531	type i collagen is a member of group i collagen (fibrillar forming collagen).
2532	syntaxin that may be involved in targeting and fusion of golgi-derived retrograde transport vesicles with the er.
2533	involved in the apoptotic response after nerve growth factor (ngf) binding in neuronal cells. binds p75ntr and antagonizes its association with trka, inhibits cell cycle progression, and facilitates p75ntr-mediated apoptosis. may act as a regulator of the function of dlx family members. may regulate p53 transcriptional activity and inhibit cell proliferation. enhances p53 phosphorylation and accumulation.
2534	
2535	
2536	potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. the effects of betacellulin are probably mediated by the egf receptor and other related receptors.
2537	
2538	
2539	receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. binding of il-8 to the receptor causes activation of neutrophils. this response is mediated via a g-protein that activate a phosphatidylinositol-calcium second messenger system. this receptor binds to il-8 with a high affinity and to gro/mgsa and nap-2 also with a high affinity.
2540	
2541	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (by similarity).
2542	may participate in forming intercisternal cross-bridges of the golgi complex.
2543	possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
2544	phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eif2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. serves as a critical effector of unfolded protein response (upr)-induced g1 growth arrest due to the loss of cyclin d1 (by similarity).
2545	
2546	subunit of the splicing factor sf3b required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex. belongs also to the minor u12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mrna intron.
2547	
2548	participates to the mitochondrial proton leak measured in brain mitochondria.
2549	plays a major role in organizing spindle poles.
2550	may mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. transports pgd2, as well as pge1, pge2 and pgf2a.
2551	
2552	
2553	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
2554	hcnp may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. hcnp increases the production of choline acetyltransferase but not acetylcholinesterase. seems to be mediated by a specific receptor (by similarity).
2555	
2556	serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (ir), ultraviolet light (uv), or dna replication stalling, thereby acting as a dna damage sensor. recognizes the substrate consensus sequence [s/t-q]. phosphorylates brca1, chek1, mcm2, rad17, rpa2, smc1 and tp53/p53, which collectively inhibit dna replication and mitosis and promote dna repair, recombination and apoptosis. phosphorylates ser-139 of histone variant h2ax/h2afx at sites of dna damage, thereby regulating dna damage response mechanism. required for fancd2 ubiquitination. critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
2557	
2558	
2559	
2560	may have a regulatory role in phosphatidylcholine synthesis.
2561	
2562	low affinity receptor for granulocyte-macrophage colony- stimulating factor. transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
2563	suppresses food intake, delays gastric emptying and decreases heat-induced edema. might represent an endogenous ligand for maintaining homeostasis after stress.
2564	may act as a gtpase activating protein for rab family protein(s).
2565	
2566	
2567	
2568	component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix.
2569	
2570	
2571	
2572	
2573	upon binding to egf receptor enhances egf-dependent mitogenic signals. can bind multiple cellular targets.
2574	
2575	
2576	
2577	possible cell death inducer, in association with other factors.
2578	activates progelatinase a. may also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. cleaves partially fibronectin, but not collagen type i, nor laminin.
2579	the heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.
2580	
2581	specifically binds to the upstream regulatory region of type i ifn and ifn-inducible mhc class i genes (the interferon consensus sequence (ics)) and represses those genes.
2582	the isoform smdf may play a role in motor and sensory neuron development.
2583	calcium-dependent mitochondrial aspartate and glutamate carrier. may have a function in the urea cycle.
2584	
2585	
2586	
2587	catalyzes the formation of the neuac-alpha-2,3-gal-beta- 1,4-glcnac-, neuac-alpha-2,3-gal-beta-1,3-glcnac- or neuac-alpha- 2,3-gal-beta-1,3-galnac- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. the highest activity is toward gal-beta-1,3-glcnac and the lowest toward gal-beta-1,3- galnac (by similarity).
2588	required maternally for proper expression of other homeotic genes involved in pattern formation, such as ubx.
2589	
2590	reversible hydration of carbon dioxide.
2591	this is a membrane-bound, calcium-inhibitable adenylyl cyclase.
2592	
2593	subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. ap-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.
2594	its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites.
2595	
2596	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
2597	
2598	
2599	
2600	
2601	apod occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. it is probably involved in the transport and binding of bilin. appears to be able to transport a variety of ligands in a number of different contexts.
2602	
2603	
2604	
2605	essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. required for the assembly of the dynein-dynactin complex onto kinetochores.
2606	may be involved in transcriptional regulation.
2607	sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. this is a non catalytic metalloprotease-like protein.
2608	not known, though may play a role in tumor or aspects of tumor progression.
2609	could be a global transcriptional regulator. modifies gene expression by affecting chromatin. may be involved in brain development and facial morphogenesis.
2610	binds specifically to nuclear core particles and acts as a transcriptional activator (by similarity).
2611	
2612	possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.
2613	
2614	
2615	could be a guanine-nucleotide releasing factor.
2616	plays a role in the formation of functional neural circuits from the early stages of synapse formation. has a role in the development of cns functions involved in locomotor activity.
2617	
2618	not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
2619	
2620	enzyme which catalyzes the acetylation of polyamines. substrate specificity: norspermidine = spermidine >> spermine > n(1)acetylspermine > putrescine. this highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. also involved in the regulation of polyamine transport out of cells.
2621	eif-2 functions in the early steps of protein synthesis by forming a ternary complex with gtp and initiator trna. this complex binds to a 40s ribosomal subunit, followed by mrna binding to form a 43s preinitiation complex. junction of the 60s ribosomal subunit to form the 80s initiation complex is preceded by hydrolysis of the gtp bound to eif-2 and release of an eif-2-gdp binary complex. in order for eif-2 to recycle and catalyze another round of initiation, the gdp bound to eif-2 must exchange with gtp by way of a reaction catalyzed by eif-2b.
2622	
2623	
2624	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
2625	
2626	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
2627	
2628	may be involved in transcriptional regulation.
2629	peripherin are class-iii neuronal intermediate filament proteins.
2630	plays a crucial role in b-cell ontogeny. transiently phosphorylates gtf2i on tyrosine residues in response to b-cell receptor crosslinking.
2631	required for ribosome biogenesis and telomere maintenance. probable catalytic subunit of h/aca small nucleolar ribonucleoprotein (h/aca snornp) complex, which catalyzes pseudouridylation of rrna. this involves the isomerization of uridine such that the ribose is subsequently attached to c5, instead of the normal n1. each rrna can contain up to 100 pseudouridine (@#$%&psi@#$%&) residues, which may serve to stabilize the conformation of rrnas. also required for correct processing or intranuclear trafficking of terc, the rna component of the telomerase reverse transcriptase (tert) holoenzyme.
2632	catalyzes the interconversion of n-acetylglucosamine to n-acetylmannosamine. binds to renin forming a protein complex called high molecular weight (hmw) renin and inhibits renin activity.
2633	
2634	plays an important role in the organization of the cytoskeleton. binds to and sequesters actin monomers (g actin) and therefore inhibits actin polymerization (by similarity).
2635	binds il13 with a low affinity. together with il4r-alpha can form a functional receptor for il13. also serves as an alternate accessory protein to the common cytokine receptor gamma chain for il4 signaling, but cannot replace the function of gamma c in allowing enhanced il2 binding activity.
2636	may play a role in spermatogenesis (by similarity).
2637	
2638	not yet known, orphan transporter.
2639	stimulates exchange activity on rho proteins in vitro, but not on cdc42, ras or rac. may bind calcium ions.
2640	
2641	c1q associates with the proenzymes c1r and c1s to yield c1, the first component of the serum complement system. the collagen-like regions of c1q interact with the ca(2+)-dependent c1r(2)c1s(2) proenzyme complex, and efficient activation of c1 takes place on interaction of the globular heads of c1q with the fc regions of igg or igm antibody present in immune complexes.
2642	id (inhibitor of dna binding) hlh proteins lack a basic dna-binding domain but are able to form heterodimers with other hlh proteins, thereby inhibiting dna binding. id-3 inhibits the binding of e2a-containing protein complexes to muscle creatine kinase e-box enhancer. may inhibit other transcription factors.
2643	mbp1 binds to the c-myc promoter and acts as a transcriptional repressor. may be a tumor suppressor.
2644	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein (by similarity).
2645	
2646	
2647	inhibits the binding of prostaglandin f2-alpha (pgf2- alpha) to its specific fp receptor, by decreasing the receptor number rather than the affinity constant. functional coupling with the prostaglandin f2-alpha receptor seems to occur.
2648	proteolytically removes the c-terminal three residues of farnesylated proteins. acts on lamin a/c.
2649	
2650	
2651	
2652	
2653	may play a role in organizing the actin cytoskeleton of the brain cells.
2654	required for activity at the locus control region (lcr) upstream of the globin gene complexes. requires p18 nf-e2 for binding to the nf-e2 motif. may play a role in all aspects of hemoglobin production: globin synthesis, heme synthesis, and the procurement of iron.
2655	forms hydroxylysine residues in -xaa-lys-gly- sequences in collagens. these hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen crosslinks.
2656	trans-acting factor that binds to glucocorticoid modulatory elements (gme) present in the tat (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. binds also to the transferrin receptor promoter. essential auxiliary factor for the replication of parvoviruses.
2657	
2658	may play a fundamental role in early development of cns. may regulate gene expression and development of postmitotic undifferentiated young neurons (by similarity).
2659	may play an important role in the capacity of cells to respond to and cope with changes in their environment. may play a role in tissue remodeling and defense against pathogens.
2660	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
2661	ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. mediates the interaction of activated endothelial cells or platelets with leukocytes. the ligand recognized is sialyl-lewis x.
2662	transcriptional regulator involved in developmental processes. can activate pomc gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.
2663	transcriptional repressor involved in developmental processes. probably plays a role in limb pattern formation.
2664	tumor suppressor probably involved in transcriptional and posttranscriptional control pathways. may be involved in cell cycle progression through the regulation of cyclin d1/prad1 expression.
2665	
2666	has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. may share a common physiologic function with the plasma-type enzyme.
2667	
2668	communication between transverse-tubules and sarcoplasmic reticulum. contraction of cardiac muscle is triggered by release of calcium ions from sr following depolarization of t- tubules (by similarity).
2669	
2670	proton-conducting pore forming subunit of the membrane integral v0 complex of vacuolar atpase. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
2671	
2672	
2673	
2674	
2675	isoform 7 behaves as a receptor and binds the secreted isoform 5. the binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. can bind to grb2 adapter protein.
2676	involved in transport of proteins into the mitochondrion. essential for embryonic development (by similarity).
2677	seems to be required for maximal rate of protein biosynthesis. enhances ribosome dissociation into subunits and stabilizes the binding of the initiator met-trna(i) to 40 s ribosomal subunits.
2678	
2679	histone h3, along with histone h4, plays a central role in nucleosome formation.
2680	receptor for adenosine. the activity of this receptor is mediated by g proteins which inhibits adenylyl cyclase. possible role in reproduction.
2681	may act as a transcriptional activator/repressor in the myeloid lineage. plays a role in the granulocyte/monocyte cell- specific response to interferon. stimulates the dna binding of the transcriptional repressor protein yy1.
2682	receptor for progesterone (by similarity). may be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) immunotoxicity.
2683	
2684	
2685	because s100a10 induces the dimerization of anxa2/p36, it may function as a regulator of protein phosphorylation in that the anxa2 monomer is the preferred target (in vitro) of tyrosine- specific kinase.
2686	shows growth cone collapsing activity on dorsal root ganglion (drg) neurons in vitro. may be a stop signal for the drg neurons in their target areas, and possibly also for other neurons. may also be involved in the maintenance and remodeling of neuronal connections.
2687	
2688	
2689	
2690	
2691	creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
2692	
2693	
2694	
2695	has antiproliferative properties in human melanoma cells and may contribute to terminal cell differentiation. may also function as a negative regulator of melanoma progression. formation in vivo in nude mice. they found that it selectively induces apoptosis in human breast cancer cells.
2696	
2697	
2698	
2699	thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. it is capable of binding to actin, calmodulin, troponin c and tropomyosin. the interaction of calponin with actin inhibits the actomyosin mg-atpase activity.
2700	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
2701	probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. when overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. may act by activating both map kinase and phosphatidylinositol 3@#$%&-kinases (pi3k) pathways (by similarity).
2702	
2703	
2704	integrin alpha-10/beta-1 is a receptor for collagen.
2705	
2706	ligand of the t-lymphocyte cd2 glycoprotein. this interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of t-lymphocytes with target cells and antigen- presenting cells and the t-lymphocyte rosetting with erythrocytes. in addition, the lfa-3/cd2 interaction may prime response by both the cd2+ and lfa-3+ cells.
2707	
2708	
2709	
2710	
2711	acts as a gtpase activating protein for rab5a. involved in receptor trafficking. in complex with eps8 inhibits internalization of egfr.
2712	
2713	component of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends.
2714	
2715	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i.
2716	
2717	
2718	
2719	plays a key role in the control of the eukaryotic cell cycle. it is required in higher cells for entry into s-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive c-terminus of rna polymerase ii.
2720	
2721	
2722	may be involved in cell-cell interactions.
2723	catalyzes the conversion of aldehydes and ketones to alcohols. catalyzes the reduction of prostaglandin (pg) d2, pgh2 and phenanthrenequinone (pq) and the oxidation of 9alpha,11beta- pgf2 to pgd2. functions as a bi-directional 3alpha-, 17beta- and 20alpha hsd. can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. preferentially transforms androstenedione (4-dione) to testosterone.
2724	
2725	involved in the posttranslational conjugation of arginine to the n-terminal aspartate or glutamate of a protein. this arginylation is required for degradation of the protein via the ubiquitin pathway. does not arginylate cysteine residues (by similarity).
2726	
2727	apoptosis-inducing protein that, which can overcome bcl- 2 suppression.
2728	plays a key role in retinoic acid metabolism. acts on retinoids, including all-trans-retinoic acid (ra) and its stereoisomer 9-cis-ra. capable of both 4-hydroxylation and 18- hydroxylation. responsible for generation of several hydroxylated forms of ra, including 4-oh-ra, 4-oxo-ra and 18-oh-ra.
2729	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis (by similarity).
2730	may be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (by similarity).
2731	receptor for interleukin-15. expression of different isoforms may alter or interfere with signal transduction. isoform 6, isoform 7, isoform 8 and isoform 9 do not bind il-15. signal transduction involves stat3, stat5, stat6, jak2 (by similarity) and syk.
2732	adds a myristoyl group to the n-terminal glycine residue of certain cellular and viral proteins.
2733	adds a myristoyl group to the n-terminal glycine residue of certain cellular and viral proteins.
2734	
2735	alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of g proteins. the rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. for antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
2736	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. associates specifically with the activated forms of the g protein subunits g(i)-alpha and g(z)- alpha but fails to interact with the structurally and functionally distinct g(s)-alpha subunit. activity on g(z)-alpha is inhibited by palmitoylation of the g-protein.
2737	
2738	
2739	
2740	muscle contraction.
2741	
2742	
2743	
2744	calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction.
2745	catalytic subunit of the nua4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. nua4 may also play a direct role in dna repair when recruited to sites of dna damage. directly acetylates and activates atm. direct binding of htatip to the tat protein of the human immunodeficiency virus (hiv) might be an important feature for efficient tat transactivation of hiv gene expression.
2746	
2747	the association of the dr1/drap1 heterodimer with tbp results in a functional repression of both activated and basal transcription of class ii genes. this interaction precludes the formation of a transcription-competent complex by inhibiting the association of tfiia and/or tfiib with tbp. can bind to dna on its own.
2748	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein.
2749	
2750	the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the er, via the golgi up to the trans golgi network. coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-er transport of dilysine-tagged proteins. in mammals, the coatomer can only be recruited by membranes associated to adp-ribosylation factors (arfs), which are small gtp-binding proteins; the complex also influences the golgi structural integrity, as well as the processing, activity, and endocytic recycling of ldl receptors (by similarity).
2751	atp-dependent rna helicase associated with the nuclear pore complex and essential for mrna export from the nucleus. may participate in a terminal step of mrna export through the removal of proteins that accompany mrna through the nucleopore complex. contributes to the blocking of bulk poly(a)+ mrna export in ethanol-stressed cells. may also be involved in early transcription.
2752	degrades collagen type i. does not act on gelatin or casein. could have a role in tumoral process.
2753	the steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
2754	phosphorylates ser-794 of irs1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction (by similarity).
2755	
2756	possible involved in germ cell rna processing and meiosis.
2757	
2758	
2759	transcription factor that binds to the octamer motif (5@#$%&-atttgcat-3@#$%&). activates cytokeratin 10 (k10) gene expression. may serve a regulatory function with respect to epidermal development. isoform 2 inhibits transactivation by oct-1.
2760	
2761	
2762	the insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.
2763	
2764	
2765	activation of the c1 complex is under control of the c1- inhibitor. it forms a proteolytically inactive stoichiometric complex with the c1r or c1s proteases. may play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins.
2766	
2767	potentially involved in docking of synaptic vesicles at presynaptic active zones.
2768	involved in cell adhesion. binds to cd166.
2769	
2770	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
2771	
2772	putative target protein of adp-ribosylation factor. involved in membrane ruffling.
2773	
2774	resistance to tetracycline by an active tetracycline efflux. this is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. this protein functions as a metal-tetracycline/h(+) antiporter.
2775	during embryonic development, some isoforms are essential for proper neuronal differentiation and organization. required for cell polarity; maintenance of apicobasal polarity. plays a critical role at septate junctions in cellular growth control during larval development. the presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
2776	
2777	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
2778	
2779	putative odorant receptor.
2780	
2781	
2782	
2783	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
2784	
2785	involved in transcriptional regulation. represses the transcription of a number of genes including gastrin, stromelysin and enolase. binds to the g-rich box in the enhancer region of these genes.
2786	
2787	links t-cell receptor activation signal to phospholipase c-gamma-1, grb-2 and phosphatidylinositol 3-kinase (by similarity).
2788	
2789	this antigen is associated with early stages of melanoma tumor progression. may play a role in growth regulation.
2790	
2791	may be a transcriptional repressor that represses both basal and activated transcription.
2792	constituent of copii-coated endoplasmic reticulum- derived transport vesicles. required for efficient transport of a subset of secretory proteins to the golgi. the c-terminal ile-leu motif is required for exit from the endoplasmic reticulum. facilitates retrograde transport from the golgi to the endoplasmic reticulum.
2793	
2794	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
2795	most effectively accelerate the intrinsic gtpase activity of ypt7. it is also active, but to a lesser extent, on ypt31, ypt32 and ypt1. ypt6 and sec4.
2796	
2797	has a preference for cgmp as a substrate.
2798	probable inhibitory regulator of the ras-cyclic amp pathway.
2799	
2800	selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
2801	facilitative glucose transporter. probably a neuronal glucose transporter.
2802	is able to inhibit all four classes of proteinases by a unique @#$%&trapping@#$%& mechanism. this protein has a peptide stretch, called the @#$%&bait region@#$%& which contains specific cleavage sites for different proteinases. when a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. the entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
2803	cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
2804	inactivates map kinases. has a specificity for the erk family.
2805	receptor for tnfsf2/tnf-alpha and homotrimeric tnfsf1/lymphotoxin-alpha. the adapter molecule fadd recruits caspase-8 to the activated receptor. the resulting death-inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. contributes to the induction of noncytocidal tnf effects including anti-viral state and activation of the acid sphingomyelinase.
2806	probably methylates the guanidino nitrogens of arginyl residues in some proteins (by similarity).
2807	binds to the il-1 type i receptor following il-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mrna stabilization. the kinase activity of this enzyme may not be required for il-1 signaling. once phosphorylated, irak1 recruits the adapter protein peli1.
2808	
2809	rna binding protein that regulates the expression of target mrnas at the translation level. regulates expression of the notch1 antagonist numb. binds rna containing the sequence 5@#$%&- guuaguuaguuaguu-3@#$%& and other sequences containing the pattern 5@#$%&- [ga]u(1-3)agu-3@#$%&. may play a role in the proliferation and maintenance of stem cells in the central nervous system (by similarity).
2810	
2811	this protein mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
2812	essential for the control of the cell cycle at the g1/s (start) transition.
2813	
2814	specifically removes c-terminal basic residues (arg or lys) from peptides and proteins. it is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.
2815	plays a role in lipoprotein assembly and dietary cholesterol absorption. in addition to its acyltransferase activity, it may act as a ligase. may provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
2816	
2817	does not seem to be a disulfide isomerase. plays an important role in the processing of secretory proteins within the endoplasmic reticulum (er), possibly by participating to the folding of proteins in the er.
2818	functions in nuclear protein import as an adapter protein for nuclear receptor kpnb1. binds specifically and directly to substrates containing either a simple or bipartite nls motif. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. in vitro, mediates the nuclear import of human cytomegalovirus ul84 by recognizing a nonclassical nls. recognizes nlss of influenza a virus nucleoprotein probably through arm repeats 7-9.
2819	probably involved in the control of the cell cycle. may play a role in transcriptional regulation. binds to and is activated by cyclin c. phosphorylates the ctd (c-terminal domain) of the large subunit of rna polymerase ii (rnap ii). recruited through interaction with maml1 to hyperphosphorylate the intracellular domain of notch, leading to its degradation.
2820	
2821	
2822	mediates the nuclear export of proteins (cargos) with broad substrate specificity. in the nucleus binds cooperatively to its cargo and to the gtpase ran in its active gtp-bound form. docking of this trimeric complex to the nuclear pore complex (npc) is mediated through binding to nucleoporins. upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of ran-gtp to ran-gdp (induced by ranbp1 and rangap1, respectively) cause release of the cargo from the export receptor. xpo4 then return to the nuclear compartment and mediate another round of transport. the directionality of nuclear export is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus.
2823	receptor for extracellular adenine nucleotides such as atp and adp. in pancreatic islets, may mediate some of the effects of extracellular atp on insulin secretion.
2824	
2825	plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. plays a key role in cholesterol metabolism.
2826	
2827	a spliceosome-associated protein; may play a role in cross-intron bridging of u1 and u2 snrnps in the mammalian a complex.
2828	
2829	
2830	appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles.
2831	
2832	
2833	subunit of the peripheral v1 complex of vacuolar atpase. vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (by similarity).
2834	
2835	
2836	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.
2837	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
2838	
2839	
2840	
2841	
2842	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules.
2843	may be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.
2844	
2845	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
2846	
2847	
2848	
2849	
2850	
2851	may function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.
2852	
2853	
2854	
2855	plays a role in the inducible expression of cytokine genes in t-cells, especially in the induction of the il-2 and il-4 (by similarity).
2856	acts as a transcriptional repressor. may be involved in dna damage-inducible cell cycle arrests (checkpoints).
2857	
2858	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
2859	may be involved in transferrin trafficking. likely to power actin-based membrane trafficking in many physiologically crucial tissues.
2860	acyl-coa synthetase probably involved in bile acid metabolism. proposed to activate c27 precurors of bile acids to their coa thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. in vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (thca), the c27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. does not utilize c24 bile acids as substrates. in vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. may be involved in translocation of long-chain fatty acids (lfca) across membranes (by similarity).
2861	
2862	
2863	
2864	atp-dependent specificity component of the clp protease. it directs the protease to specific substrates. can perform chaperone functions in the absence of clpp (by similarity).
2865	
2866	
2867	
2868	
2869	
2870	
2871	essential component of nuclear pore complex. required for the assembly of peripheral proteins into the nuclear pore complex.
2872	
2873	
2874	
2875	
2876	probably plays an important role in the regulation of erythrocyte shape and mechanical properties.
2877	
2878	
2879	tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
2880	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
2881	type i collagen is a member of group i collagen (fibrillar forming collagen).
2882	
2883	
2884	
2885	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. this subunit is involved in antigen processing to generate class i binding peptides.
2886	
2887	
2888	
2889	
2890	plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.
2891	
2892	
2893	
2894	
2895	carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria (by similarity).
2896	probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization.
2897	might play an important role in basic cellular processes as a transcriptional repressor.
2898	atp-dependent rna helicase involved in mrna export from the nucleus.
2899	
2900	ca(2+)-dependent modulation of synaptic efficacy.
2901	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
2902	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
2903	may be involved in transcriptional regulation.
2904	
2905	
2906	acts as a multispecific organic anion pump which can transport nucleotide analogs (by similarity).
2907	
2908	major enzyme for galactose metabolism.
2909	highly selective for arachidonate-containing species of diacylglycerol (dag). may terminate signals transmitted through arachidonoyl-dag or may contribute to the synthesis of phospholipids with defined fatty acid composition.
2910	part of the host defense system of polymorphonuclear leukocytes. it is responsible for microbicidal activity against a wide range of organisms. in the stimulated pmn, mpo catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance pmn microbicidal activity.
2911	
2912	
2913	
2914	
2915	
2916	
2917	may be involved in transcriptional regulation.
2918	this is a receptor for glucagon-like peptide 2. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
2919	
2920	tfiif is a general transcription initiation factor that binds to rna polymerase ii and helps to recruit it to the initiation complex in collaboration with tfiib. it promotes transcription elongation. this subunit shows atp-dependent dna- helicase activity.
2921	phosphorylates specifically ribosomal protein s6 in response to insulin or several classes of mitogens.
2922	
2923	
2924	
2925	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
2926	cbf binds to the core site, 5@#$%&-pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, lck, il-3 and gm-csf promoters. the alpha subunit binds dna and appears to have a role in the development of normal hematopoiesis. isoform aml-1l interferes with the transactivation activity of runx1. acts synergistically with elf4 to transactivate the il-3 promoter and with elf2 to transactivate the mouse blk promoter. inhibits myst4- dependent transcriptional activation.
2927	
2928	
2929	
2930	acts as a transcriptional activator of the c-myc gene; binds dna nonspecifically (ref.3).
2931	
2932	may inhibit tumor metastasis (by similarity). in vitro, reduces cell motility.
2933	
2934	
2935	potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
2936	p35 is a neuron specific activator of cdk5. the complex p35/cdk5 is required for neurite outgrowth and cortical lamination. activator of tpkii.
2937	
2938	
2939	
2940	
2941	
2942	transcription factor that controls the expression of the th1 cytokine, interferon-gamma. initiates th1 lineage development from naive th precursor cells both by activating th1 genetic programs and by repressing the opposing th2 programs.
2943	
2944	glycosyltransferase required for the biosynthesis of heparan-sulfate. the ext1/ext2 complex possesses substantially higher glycosyltransferase activity than ext1 or ext2 alone. appears to be a tumor suppressor.
2945	the normal physiological role of blm hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug blm (a glycopeptide) by hydrolyzing the carboxamide bond of its b- aminoalaninamide moiety thus protecting normal and malignant cells from blm toxicity (by similarity).
2946	in the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (krtap), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. the matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
2947	may be involved in processing of pre-ribosomal rna.
2948	orphan receptor. could be a chemokine receptor.
2949	may play a role in cell proliferation, differentiation and death.
2950	
2951	
2952	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
2953	
2954	
2955	
2956	cytokine that binds to tnfrsf13b/taci and tnfrsf17/bcma. tnfsf13/april binds to the same 2 receptors. together, they form a 2 ligands -2 receptors pathway involved in the stimulation of b- and t-cell function and the regulation of humoral immunity. a third b-cell specific baff-receptor (baffr/br3) promotes the survival of mature b-cells and the b-cell response.
2957	required for vesicular transport between the endoplasmic reticulum and the golgi apparatus.
2958	required for vesicular transport between the endoplasmic reticulum and the golgi apparatus.
2959	transcriptional activator that exhibits a unique dna binding specificity for [ac]cpg[ac] unmethylated cpg motifs.
2960	
2961	might function as an inhibitor of lys-specific proteases. might influence the maturation of megakaryocytes via its action as a serpin.
2962	
2963	accepts the ubiquitin-like protein nedd8 from the ube1c- appbp1 e1 complex and catalyzes its covalent attachment to other proteins. involved in cell proliferation.
2964	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
2965	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
2966	may be involved in transcriptional regulation.
2967	
2968	not known. used by poliovirus to bind and enter the cell.
2969	the elongation of primed dna templates by dna polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (pcna) and activator 1.
2970	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
2971	
2972	
2973	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
2974	
2975	involved in transcription.
2976	
2977	
2978	
2979	regulatory factor essential for mhc class ii genes expression. binds to the x boxes of mhc class ii genes. also binds to an inverted repeat (enh1) required for hepatitis b virus genes expression and to the most upstream element (alpha) of the rpl30 promoter.
2980	involved in redox regulation of the cell. reduces peroxides with reducing equivalents provided through the thioredoxin system. it is not able to receive electrons from glutaredoxin. may play an important role in eliminating peroxides generated during metabolism. might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of h(2)o(2).
2981	
2982	
2983	
2984	orphan receptor.
2985	may play a role in the regulation of calcium sequestration or release in the sr of skeletal and cardiac muscle.
2986	
2987	
2988	
2989	
2990	transcription activator for a number of liver genes such as afp, albumin, tyrosine aminotransferase, pepck, etc. interacts with the cis-acting regulatory regions of these genes.
2991	
2992	
2993	may act as receptor for class i mhc antigens.
2994	
2995	involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule.
2996	arm and abl proteins function cooperatively at adherens junctions in both the cns and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone@#$%&s response to midline cues. the ability of pcc/mp2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both slit/robo and abl-dependent signaling pathways.
2997	
2998	may antagonize nodal signaling and subsequent organization of axial structures during mesodermal patterning (by similarity).
2999	probably plays an important role in metabolic homeostasis in mitochondria. may function as a nuclear-cytoplasmic shuttling protein that binds transcription factor rela/nfkb3 in the nucleus and exports it to the cytoplasm. suppresses p53- induced apoptosis by preventing nuclear localization of rela.
3000	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb (by similarity).
3001	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb (by similarity).
3002	seems to play an essential role in cold-induced suppression of cell proliferation.
3003	
3004	
3005	
3006	polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types i, iii, and iv (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.
3007	binds to activated (phosphorylated) protein-tyrosine kinases, through its sh2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
3008	anchoring protein that mediates the subcellular compartmentation of camp-dependent protein kinase (pka type ii).
3009	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
3010	
3011	
3012	
3013	
3014	
3015	
3016	
3017	
3018	involved in the regulation of growth and apoptosis. mediates activation of stress-responsive mtk1/mekk4 mapkkk.
3019	
3020	
3021	
3022	transcriptional inhibitor that binds to dna sequence 5@#$%&- cacct-3@#$%& in different promoters (by similarity).
3023	
3024	enzyme with a broad specificity.
3025	crystallins are the dominant structural components of the vertebrate eye lens.
3026	
3027	associates with the ryanodine receptor (ryr-2) in cardiac muscle sarcoplasmic reticulum and may play a unique physiological role in excitation-contraction coupling in cardiac muscle. there are four molecules of fkbp12.6 per heart muscle ryr. has the potential to contribute to the immunosuppressive and toxic effects of fk506 and rapamycin. ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
3028	
3029	may be involved in transcriptional regulation.
3030	likely to play an important role in intracellular protein and peptide metabolism.
3031	
3032	
3033	may be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. may function as a regulator of ergic-53.
3034	calcium-dependent mitochondrial aspartate and glutamate carrier. may have a function in the urea cycle.
3035	
3036	required for membrane traffic to the vacuole.
3037	may play a role in the regulation of t and b-lymphocyte development and signal transduction (by similarity).
3038	following activation by double-stranded rna in the presence of atp, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor eif2s1, which leads to an inhibition of the initiation of protein synthesis. double-stranded rna is generated during the course of a viral infection.
3039	
3040	putative voltage-gated potassium channel.
3041	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the complex p170-eif3.
3042	
3043	appears to play a role in cell sterol metabolism. it may function to protect cells from over-accumulation of cholesterol.
3044	noncatalytic subunit of the peripheral v1 complex of vacuolar atpase. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
3045	
3046	required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
3047	v-snare that mediates vesicle transport pathways through interactions with t-snares on the target membrane. these interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.
3048	
3049	
3050	
3051	segment polarity protein, functions together with arm to transduce the wingless (wg) signal. acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
3052	
3053	
3054	
3055	
3056	may be involved in transcriptional regulation.
3057	gtpase activator for the rho-type gtpases by converting them to an inactive gdp-bound state (by similarity).
3058	may play a role in neuron-specific rna processing.
3059	stimulates prolactin (prl) release and regulates the expression of prolactin through its receptor gpr10. may stimulate lactotrophs directly to secrete prl.
3060	
3061	
3062	
3063	subunit of the peripheral v1 complex of vacuolar atpase essential for assembly or catalytic function. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
3064	probable atpase involved in the assembly or function of nuclear protein complexes. may also be involved in some aspects of microtubule dynamics (by similarity).
3065	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
3066	involved in mitochondria homeostasis. may be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial dna (mtdna) maintenance.
3067	
3068	cleaves the membrane-bound precursor of tnf-alpha to its mature soluble form. responsible for the proteolytic release of several other cell-surface proteins, including p75 tnf-receptor, interleukin 1 receptor type ii, p55 tnf-receptor, transforming growth factor-alpha, l-selectin, growth hormone receptor and the amyloid precursor protein. also involved in the activation of notch pathway (by similarity).
3069	may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (by similarity).
3070	id (inhibitor of dna binding) hlh proteins lack a basic dna-binding domain but are able to form heterodimers with other hlh proteins, thereby inhibiting dna binding. id-2 may be an inhibitor of tissue-specific gene expression.
3071	collagen type iii occurs in most soft connective tissues along with type i collagen.
3072	binds to the lipid a moiety of bacterial lipopolysaccharides (lps), a glycolipid present in the outer membrane of all gram-negative bacteria. the lbp/lps complex seems to interact with the cd14 receptor.
3073	transcription factor involved in the regulation of cell survival, proliferation, and differentiation. transactivates the expression of the clu gene.
3074	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. may mediate nef-induced down-regulation of cd4. major thioesterase in peroxisomes. competes with baat (bile acid coa: amino acid n- acyltransferase) for bile acid-coa substrate (such as chenodeoxycholoyl-coa). shows a preference for medium-length fatty acyl-coas (by similarity). may be involved in the metabolic regulation of peroxisome proliferation.
3075	important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. specifically binds to an il-1 response element in the il-6 gene. nf-il6 also binds to regulatory regions of several acute-phase and cytokines genes. it probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. the consensus recognition site is 5@#$%&-t[tg]nngnaa[tg]-3@#$%&.
3076	
3077	
3078	may play a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. there are four molecules of fkbp12 per skeletal muscle ryr. ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
3079	
3080	
3081	induces cartilage and bone formation.
3082	
3083	
3084	required for protein transport from the er to the golgi complex.
3085	may be involved in the airway inflammatory response after exposure to irritants. may be associated with tumor progression. may play a role in innate immune responses of the upper airways.
3086	
3087	
3088	binds to type ii regulatory subunits of protein kinase a and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. may act as an adapter for assembling multiprotein complexes.
3089	
3090	
3091	this protein seems to be part of the stalk that links cf(0) to cf(1). it either transmits conformational changes from cf(0) into cf(1) or is implicated in proton conduction.
3092	part of the complex catalyzing the transfer of n- acetylglucosamine from udp-n-acetylglucosamine to phosphatidylinositol, the first step of gpi biosynthesis.
3093	binds to type ii regulatory subunits of protein kinase a and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. may act as an adapter for assembling multiprotein complexes.
3094	may be involved in modulating hsf2 activation in testis.
3095	
3096	weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. binds to and initiates the activation of stk38 by releasing autoinhibitory intramolecular interactions within the kinase.
3097	required for 7-methylguanosine modification of trna.
3098	subunit of the peripheral v1 complex of vacuolar atpase essential for assembly or catalytic function. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
3099	clathrin is the major protein of the polyhedral coat of coated pits and vesicles. two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-golgi network (by similarity).
3100	may have a role in early embryogenesis.
3101	
3102	
3103	crystallins are the dominant structural components of the vertebrate eye lens.
3104	enhances nf-kappa-b, srf and ap1 transactivation.
3105	
3106	the s.cerevisiae ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-amp.
3107	
3108	
3109	binds differentially to the sh3 domains of certain proteins of signal transduction pathways. this protein binds preferentially to the abl1 proto-oncogene, src and grb2. shows gap activity for rac-related proteins but not for rho- or ras-related proteins. it inhibits pdgf-induced membrane ruffling mediated by rac (by similarity).
3110	transcription factor that seems to function synergistically with the pou domain protein tst-1/oct6/scip. could confer cell specificity to the function of other transcription factors in developing and mature glia (by similarity).
3111	
3112	interacts with slp-76 to regulate nf-at activation. binds to tyrosine-phosphorylated shc.
3113	
3114	
3115	
3116	
3117	
3118	this protein binds the hiv-1 tata element and inhibits transcriptional activation by the tata-binding protein (tbp).
3119	
3120	
3121	could be involved in normal hemopoietic differentiation as well as in erythroid/myeloid lineage switching (by similarity).
3122	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of the calcium.
3123	involved in axon growth. plays an essential role in neurite extension of cerebellar granule cells.
3124	
3125	
3126	inhibits the auto- and transphosphorylation activity of btk. plays a negative regulatory role in btk-related cytoplasmic signaling in b-cells. may be involved in bcr-induced apoptotic cell death.
3127	its binding to fibronectin and some other ligands is calcium dependent.
3128	functions as an e1 enzyme essential for multisubstrates such as gabarapl1 and atg12. forms intermediate conjugates with gabarapl1 (gabarapl2, gabarap or map1alc3). formation of the final gabarapl1-pe conjugate is essential for autophagy (by similarity).
3129	
3130	
3131	this is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters. may play a role in antigen-dependent control of b-cell function.
3132	stratified squamous epithelial basement membrane protein that form anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ecm) proteins such as type iv collagen.
3133	
3134	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems. the g(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli.
3135	
3136	
3137	
3138	
3139	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
3140	
3141	probable acetyl-coa transporter necessary for o- acetylation of gangliosides.
3142	translation factor necessary for the incorporation of selenocysteine into proteins. it probably replaces ef-tu for the insertion of selenocysteine directed by the uga codon. selb binds gtp and gdp.
3143	required for preprotein translocation (by similarity).
3144	
3145	component of the cop9 signalosome complex (csn), a complex involved in various cellular and developmental processes. the csn complex is an essential regulator of the ubiquitin (ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of scf-type e3 ligase complexes, leading to decrease the ubl ligase activity of scf-type complexes such as scf, csa or ddb2. the complex is also involved in phosphorylation of p53/tp53, c-jun/jun, ikappabalpha/nfkbia, itpk1 and irf8/icsbp, possibly via its association with ck2 and pkd kinases. csn-dependent phosphorylation of tp53 and jun promotes and protects degradation by the ubl system, respectively.
3146	receptor that accelerates the import of all mitochondrial precursor proteins (by similarity).
3147	muscle contraction.
3148	
3149	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
3150	
3151	
3152	
3153	component of the circadian clock or downstream effector of clock function. exhibits a high amplitude circadian rhythm with maximal levels in early evening. in constant darkness or constant light, the amplitude of the rhythm decreases (by similarity).
3154	thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. during neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. slit1 and slit2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. in spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. in vitro, silences the attractive effect of ntn1 but not its growth- stimulatory effect and silencing requires the formation of a robo1-dcc complex. may be implicated in spinal chord midline post- crossing axon repulsion. in vitro, only commissural axons that crossed the midline responded to slit2. in the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. in vitro, collapses and repels retinal ganglion cell growth cones. seems to play a role in branching and arborization of cns sensory axons, and in neuronal cell migration. in vitro, slit homolog 2 protein n-product, but not slit homolog 2 protein c-product, repels olfactory bulb (ob) but not dorsal root ganglia (drg) axons, induces ob growth cones collapse and induces branching of drg axons. seems to be involved in regulating leukocyte migration.
3155	
3156	
3157	
3158	catalyzes the initial reaction in o-linked oligosaccharide biosynthesis, the transfer of an n-acetyl-d- galactosamine residue to a serine or threonine residue on the protein receptor. has a broad spectrum of substrates for peptides such as ea2, muc5ac, muc1a, muc1b and muc7.
3159	important role in determination of the surface properties of the casein micelles.
3160	may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.
3161	
3162	
3163	bifunctional enzyme with both atp sulfurylase and aps kinase activity, which mediates two steps in the sulfate activation pathway. the first step is the transfer of a sulfate group to atp to yield adenosine 5@#$%&-phosphosulfate (aps), and the second step is the transfer of a phosphate group from atp to aps yielding 3@#$%&-phosphoadenylylsulfate (paps: activated sulfate donor used by sulfotransferase). in mammals, paps is the sole source of sulfate; aps appears to be only an intermediate in the sulfate- activation pathway. also involved in the biosynthesis of sulfated l-selectin ligands in endothelial cells.
3164	may function as an antagonist of fibroblast growth factor (fgf) pathways and may negatively modulate respiratory organogenesis.
3165	could function as a cell-adhesion protein. acts as a tumor suppressor. required for correct morphogenesis.
3166	
3167	cleaves the propeptides of type i and ii collagen prior to fibril assembly. does not act on type iii collagen. may also play a role in development that is independent of its role in collagen biosynthesis.
3168	phosphorylates eukaryotic elongation factor-2. binds calmodulin (by similarity).
3169	binds tightly to hydroxyapatite. appears to form an integral part of the mineralized matrix. probably important to cell-matrix interaction. promotes arg-gly-asp-dependent cell attachment.
3170	
3171	
3172	
3173	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
3174	functions in nuclear protein import as an adapter protein for nuclear receptor kpnb1. binds specifically and directly to substrates containing either a simple or bipartite nls motif. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. mediates nuclear import of stat1 homodimers and stat1/stat2 heterodimers by recognizing nonclassical nlss of stat1 and stat2 through arm repeats 8-9. recognizes influenza a virus nucleoprotein through arm repeat 7-9 in vitro, mediates the nuclear import of human cytomegalovirus ul84 by recognizing a nonclassical nls.
3175	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
3176	
3177	
3178	implicated in brca1-mediated tumor suppression. may, as part of the rna polymerase-2 holoenzyme, function in the cellular response to dna damage. in vitro, inhibits pre-mrna 3@#$%& cleavage.
3179	
3180	may be involved in transcriptional regulation. plays a role during development and organogenesis as well as in the function of the adult central nervous system (by similarity).
3181	receptor for activated thrombin coupled to g proteins that stimulate phosphoinositide hydrolysis.
3182	
3183	
3184	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
3185	
3186	
3187	forms a channel through the mitochondrial outer membrane and also the plasma membrane. the channel allows diffusion of small hydrophilic molecules; it adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mv. the open state has a weak anion selectivity whereas the closed state is cation-selective. may participate in the formation of the permeability transition pore complex (ptpc) responsible for the release of mitochondrial products that triggers apoptosis.
3188	
3189	probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. is not an essential protein. involved in substrate recognition in ubiquitin-dependent degradation.
3190	may have potent implications in lung endothelial cell- leukocyte interactions.
3191	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
3192	binds gangliosides and stimulates ganglioside gm2 degradation. it stimulates only the breakdown of ganglioside gm2 and glycolipid ga2 by beta-hexosaminidase a. it extracts single gm2 molecules from membranes and presents them in soluble form to beta-hexosaminidase a for cleavage of n-acetyl-d-galactosamine and conversion to gm3.
3193	binds gangliosides and stimulates ganglioside gm2 degradation. it stimulates only the breakdown of ganglioside gm2 and glycolipid ga2 by beta-hexosaminidase a. it extracts single gm2 molecules from membranes and presents them in soluble form to beta-hexosaminidase a for cleavage of n-acetyl-d-galactosamine and conversion to gm3.
3194	
3195	
3196	
3197	controls the flux of glucose into the hexosamine pathway. most likely involved in regulating the availability of precursors for n- and o-linked glycosylation of proteins.
3198	
3199	transcriptional modulator activated by bmp (bone morphogenetic proteins) type 1 receptor kinase. smad5 is a receptor-regulated smad (r-smad).
3200	may play a role in intercellular signaling and in connecting cells with the extracellular matrix. may take part in the regulation of cell motility, growth and differentiation. binds hyaluronic acid.
3201	
3202	
3203	
3204	may act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (nr). isoform 2 stimulates transcriptional activation by ar/dhtr, esr1/nr3a1, rxra/nr2b1 and thrb/erba2. at least isoform 1 and isoform 2 are components of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. nua4 may also play a direct role in dna repair when recruited to sites of dna damage.
3205	beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of g proteins. the beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
3206	catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues.
3207	
3208	involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)u34) of the wobble uridine base in mitochondrial trnas.
3209	nuclear receptor coactivator. may play a role in signal transduction.
3210	
3211	molecular chaperone. has atpase activity (by similarity).
3212	modulates the action of platelet-activating factor (paf) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-paf. has a specificity for substrates with a short residue at the sn-2 position. it is inactive against long-chain phospholipids.
3213	
3214	
3215	may be a dna-binding protein with a regulatory function. may play an important role in cell death and/or in regulation of cell proliferation.
3216	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. displays high levels of activity on medium- and long chain acyl coas.
3217	may be a dna-binding protein with a regulatory function. may play an important role in cell death and/or in regulation of cell proliferation.
3218	
3219	could be involved with trophinin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.
3220	receptor for neuropeptide y and peptide yy.
3221	
3222	
3223	has broad antibacterial activity. may contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
3224	
3225	
3226	involved in the presentation of foreign antigens to the immune system.
3227	possible regulatory or functional link with the histocompatibility cluster.
3228	
3229	type i collagen is a member of group i collagen (fibrillar forming collagen).
3230	
3231	in the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the a repressor bcl-2 or its adenovirus homolog e1b 19k protein.
3232	involved in vesicular protein trafficking.
3233	
3234	responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. plays a role in the regulation of protein translation by phosphorylating and inactivating eef2k.
3235	
3236	may play a role in transcriptional regulation. binds to and activates cyclin-dependent kinase cdk8 that phosphorylates the ctd (carboxy-terminal domain) of the large subunit of rna polymerase ii (rnap ii).
3237	alpha-l-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end n- acetylglucosamine of the carbohydrate moieties of glycoproteins (by similarity).
3238	cell autonomous negative regulator of lin-12/notch- mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. may function as part of an e3 complex to target the intracellular domains of lin-12/notch proteins for ubiquitin-dependent degradation.
3239	inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. receptor for beta-endorphin.
3240	
3241	
3242	extremely potent competitive inhibitor of camp-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the camp-induced dissociation of its regulatory chains (by similarity).
3243	
3244	high-affinity glucose transporter. is only indispensable for growth on low glucose-containing media, because s.cerevisiae possesses other sugar transporters.
3245	catalyzes the covalent attachment of ubiquitin to other proteins. capable, in vitro, to ubiquitinate histone h2a.
3246	
3247	the muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of g proteins. primary transducing effect is adenylate cyclase inhibition.
3248	
3249	
3250	receptor for the glycosphingolipid psychosine (psy) and several related glycosphingolipids. may have a role in activation- induced cell death or differentiation of t-cells.
3251	catalyzes the decarboxylation of l-3,4- dihydroxyphenylalanine (dopa) to dopamine, l-5-hydroxytryptophan to serotonin and l-tryptophan to tryptamine.
3252	
3253	required for maximal atpase activity of brg1 and are also required with brg1 for association of the complex with chromatin/matrix (by similarity).
3254	
3255	racemization of 2-methyl-branched fatty acid coa esters. responsible for the conversion of pristanoyl-coa and c27-bile acyl-coas to their (s)-stereoisomers.
3256	removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid a region of bacterial lipopolysaccharides.
3257	inhibits protein phosphatase-2a and protein phosphatase- 1.
3258	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. acts on the anterior body structures. seems to act in the maintenance and/or generation of hindbrain segments.
3259	does not act as an allosteric activator of the cholera toxin catalytic subunit (by similarity).
3260	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
3261	
3262	
3263	may be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction enhances wnt signaling and inhibits tgf-beta signaling (by similarity). directly antagonizes activity of bmp2, bmp4, bmp6 and bmp7 in a dose-dependent manner.
3264	receptor for hepatocyte growth factor and scatter factor. has a tyrosine-protein kinase activity.
3265	
3266	gtpase-activating protein for the adp ribosylation factor family (probable). binds phosphatidylinositol 3,4,5- trisphosphate (ptdinsp3) and inositol 1,3,4,5-tetrakisphosphate (insp4).
3267	
3268	may play a role in meiosis as well as in neuron differentiation and/or function (by similarity).
3269	
3270	
3271	
3272	kinase-defective receptor for members of the ephrin-b family.
3273	catalyzes the phosphorylation of thiamine to thiamine pyrophosphate.
3274	catalyzes the o-sulfation of tyrosine residues within acidic motifs of polypeptides.
3275	this is a receptor for vip as well as pacap-38 and -27, the activity of this receptor is mediated by g proteins which activate adenylyl cyclase. can be coupled to phospholipase c.
3276	
3277	
3278	responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain.
3279	subunit of the peripheral v1 complex of vacuolar atpase. subunit c is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
3280	mediates the association of the molecular chaperones hsc70 and hsp90 (hspca and hspcb).
3281	plays a role in papillomavirus genes transcription.
3282	maintains high levels of reduced glutathione in the cytosol.
3283	
3284	
3285	growth factor active on keratinocytes. possible major paracrine effector of normal epithelial cell proliferation.
3286	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
3287	dual specificity phosphatase that dephosphorylates map kinase fus3 on both a tyr and a ser or thr. has a role in adaptation to pheromone.
3288	subunit of the integral membrane v0 complex of vacuolar atpase. vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.
3289	involved in ribosome biogenesis (by similarity).
3290	
3291	the primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (vldl). the enzyme functions in the presence of apolipoprotein c-2 on the luminal surface of vascular endothelium.
3292	mediates the nuclear export of proteins (cargos) with broad substrate specificity. in the nucleus binds cooperatively to its cargo and to the gtpase ran in its active gtp-bound form. docking of this trimeric complex to the nuclear pore complex (npc) is mediated through binding to nucleoporins. upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of ran-gtp to ran-gdp (induced by ranbp1 and rangap1, respectively) cause release of the cargo from the export receptor. xpo7 then return to the nuclear compartment and mediate another round of transport. the directionality of nuclear export is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus.
3293	may play a role in neuronal differentiation, and in modulating membrane interaction with the cytoskeleton during neurite outgrowth.
3294	catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
3295	regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. confers calcium sensitivity.
3296	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
3297	participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles.
3298	
3299	transfers mannosyl residues to the hydroxyl group of serine or threonine residues. coexpression of both pomt1 and pomt2 is necessary for enzyme activity, expression of either pomt1 or pomt2 alone is insufficient.
3300	component of the elastin-associated microfibrils.
3301	transfers mannosyl residues to the hydroxyl group of serine or threonine residues. coexpression of both pomt1 and pomt2 is necessary for enzyme activity, expression of either pomt1 or pomt2 alone is insufficient.
3302	
3303	may function in nuclear protein import as nuclear transport receptor.
3304	
3305	
3306	
3307	cysteine protease. may have an important role in corneal physiology.
3308	guanine nucleotide exchange factor for the rho family of ras-related gtpases.
3309	
3310	implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2a, regulation of mrna trafficking and stability in association with elavl1, and inhibition of acetyltransferases as part of the inhat (inhibitor of histone acetyltransferases) complex.
3311	
3312	
3313	produced by macrophages, ifn-alpha have antiviral activities. interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
3314	
3315	catalyzes the conversion of pgh2 to pgd2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. involved in a variety of cns functions, such as sedation, nrem sleep and pge2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. it is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
3316	
3317	catalyzes the formation of some glycolipid via the addition of n-acetylgalactosamine (galnac) in alpha-1,3-linkage to some substrate. glycolipids probably serve for adherence of some pathogens.
3318	
3319	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
3320	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release. has anti-apoptotic activity. markedly increases the anti-cell death function of bcl2 induced by various stimuli.
3321	
3322	may be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. may also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
3323	
3324	
3325	this giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. bind and stabilize f-actin.
3326	synthesizes selenophosphate from selenide and atp.
3327	hydrolyzes adenosine 5@#$%&-monophosphoramidate substrates such as amp-morpholidate, amp-n-alanine methyl ester, amp-alpha- acetyl lysine methyl ester and amp-nh2 (by similarity).
3328	
3329	
3330	
3331	
3332	
3333	
3334	
3335	shows moderate inhibition of cathepsin b but is not active against cathepsin c.
3336	
3337	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
3338	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
3339	
3340	receptor for members of the ephrin-a family. binds to ephrin-a2, -a3, -a4 and -a5. could play a role in lymphoid function.
3341	
3342	attaches integral membrane proteins to cytoskeletal elements. also binds to cytoskeletal proteins. required for coordinate assembly of na/ca exchanger, na/k atpase and insp3 receptor at sarcoplasmic reticulum sites in cardiomyocytes.
3343	
3344	
3345	may be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a krab b-domain.
3346	
3347	calcium channel protein which plays an important role in excitation-contraction coupling.
3348	calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. it may act in assisting protein assembly and/or in the retention within the er of unassembled protein subunits. it seems to play a major role in the quality control apparatus of the er by the retention of incorrectly folded proteins.
3349	may be involved in transcriptional regulation.
3350	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
3351	
3352	
3353	non-catalytic subunit of the trna-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-trna. it cleaves pre-trna at the 5@#$%& and 3@#$%& splice sites to release the intron. the products are an intron and two trna half-molecules bearing 2@#$%&,3@#$%& cyclic phosphate and 5@#$%&-oh termini. there are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the trna body. the trna splicing endonuclease is also involved in mrna processing via its association with pre-mrna 3@#$%& end processing factors, establishing a link between pre-trna splicing and pre-mrna 3@#$%& end formation, suggesting that the endonuclease subunits function in multiple rna-processing events.
3354	
3355	in the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing non-specifically a variety of target cells.
3356	multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
3357	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
3358	
3359	
3360	
3361	probable motor protein.
3362	cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. dynein has atpase activity; the force-producing power stroke is thought to occur on release of adp.
3363	
3364	cleaves the large aggregating proteoglycans, aggrecan and versican.
3365	
3366	
3367	
3368	functions within a multiprotein e3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. these substrates include syt11, ccne1, gpr37, stub1, a 22 kda o-linked glycosylated isoform of sncaip and sept5. may play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of park2. may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. regulates cyclin e during neuronal apoptosis. may represent a tumor suppressor gene.
3369	
3370	
3371	stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
3372	it has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1. it is essential for growth or germination at 37 degrees celsius. may have a role in the heat shock response. involved in trna splicing and cell separation.
3373	
3374	
3375	necessary for efficient rna polymerase ii transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by s-ii allows the resumption of elongation from the new 3@#$%&terminus.
3376	component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix.
3377	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
3378	
3379	calmodulin mediates the control of a large number of enzymes and other proteins by ca(2+). among the enzymes to be stimulated by the calmodulin-ca(2+) complex are a number of protein kinases and phosphatases.
3380	receptor for atrial natriuretic peptide. has guanylate cyclase activity on binding of anf.
3381	
3382	important for the overall degradation of proteins in lysosomes.
3383	
3384	may be involved in transcriptional regulation.
3385	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
3386	
3387	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. the produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
3388	
3389	
3390	
3391	
3392	
3393	
3394	
3395	probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. recognizes and binds to the dna sequence 5@#$%&-atgcaaat-3@#$%&. isoform 1 does not bind dna.
3396	
3397	
3398	
3399	may be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. may also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
3400	component of pa700, an atp-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20s proteasome) of the 26s complex. specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone t3-independent manner) and with retinoid x receptor (rxr). could be e3 ubiquitin- protein ligase which accepts ubiquitin from an e2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
3401	assembly protein recruiting clathrin and adaptor protein complex 2 (ap2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. involved in ap2-dependent clathrin-mediated endocytosis at the neuromuscular junction.
3402	inhibitor of the wnt signaling pathway. down-regulates beta-catenin. probably facilitate the phosphorylation of beta- catenin and apc by gsk3b (by similarity).
3403	regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair (by similarity).
3404	
3405	fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
3406	
3407	
3408	essential component of the nelf complex, a complex that negatively regulates the elongation of transcription by rna polymerase ii. the nelf complex, which acts via an association with the dsif complex and causes transcriptional pausing, is counteracted by the p-tefb kinase complex.
3409	
3410	member of grp1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. may function as a scaffolding protein (by similarity).
3411	
3412	has an effect on position-effect variegation.
3413	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
3414	
3415	may be involved in n-glycosylation through its association with n-oligosaccharyl transferase.
3416	may be active in cell adhesion processes during retinal development.
3417	
3418	
3419	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
3420	one of the multiple factors required for polyadenylation and 3@#$%&-end cleavage of mammalian pre-mrnas. this subunit is directly involved in the binding to pre-mrnas (by similarity).
3421	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
3422	controls phosphatidylcholine synthesis.
3423	
3424	catalyzes the covalent attachment of ubiquitin to other proteins. required for postreplication repair of uv-damaged dna.
3425	probably involved in ubiquitination and subsequent proteasomal degradation of target proteins. plays a role in the polyubiquitination of cdt1 in response to radiation-induced dna damage.
3426	motor protein that translocates prc1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. may play a role in mitotic chromosomal positioning and bipolar spindle stabilization.
3427	acts as a negative coregulator for lim homeodomain transcription factors. via the recruitment of the sin3a/histone deacetylase corepressor complex.
3428	involved in the degradation of asparagine-linked glycoproteins. hydrolyze of n-acetyl-beta-d-glucosamine (1-4)n- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.
3429	
3430	the exact function of this protein is not known. it is probably a receptor with a tyrosine-protein kinase activity.
3431	
3432	in complex with narg1, displays alpha (n-terminal) acetyltransferase activity. without narg1, displays epsilon (internal) acetyltransferase activity towards hif1a, thereby promoting its degradation.
3433	probable transporter. the nucleotide-binding fold acts as an atp-binding subunit with atpase activity.
3434	involved in the export of mrna from the nucleus to the cytoplasm.
3435	
3436	activates ubiquitin by first adenylating with atp its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in e1, yielding an ubiquitin-e1 thioester and free amp.
3437	activates ubiquitin by first adenylating with atp its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in e1, yielding an ubiquitin-e1 thioester and free amp.
3438	seems to be required for maximal rate of protein biosynthesis. enhances ribosome dissociation into subunits and stabilizes the binding of the initiator met-trna(i) to 40 s ribosomal subunits.
3439	binds to myosin; probably involved in interaction with thick myofilaments in the a-band.
3440	
3441	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. srp9 together with srp14 and the alu portion of the srp rna, constitutes the elongation arrest domain of srp. the complex of srp9 and srp14 is required for srp rna binding.
3442	coagulation factor v is a cofactor that participates with factor xa to activate prothrombin to thrombin.
3443	transcriptional regulator involved in developmental processes. can activate pomc gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.
3444	deubiquitinating enzyme.
3445	seems to phosphorylate critical substrates that regulate the g1/s phase transition and/or dna replication. can phosphorylates mcm2 and mcm3.
3446	required for the methylation step in diphthamide biosynthesis (by similarity).
3447	
3448	
3449	
3450	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
3451	this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of sodium and potassium ions across the plasma membrane. this action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
3452	
3453	
3454	involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
3455	cross-linked envelope protein of keratinocytes. it is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. all that results in the formation of an insoluble envelope beneath the plasma membrane.
3456	
3457	
3458	
3459	
3460	recruited and tyrosine phosphorylated by several receptor systems, for example the t-cell, leptin and insulin receptors. once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to sh2 and sh3 domain- containing proteins. role in g2-m progression in the cell cycle. represses cbp-dependent transcriptional activation apparently by competing with other nuclear factors for binding to cbp. also acts as a putative regulator of mrna stability and/or translation rates and mediates mrna nuclear export. isoform 3 is only expressed in growth-arrested cells and inhibits s phase entry.
3461	might be involved in angiogenesis inhibition.
3462	required for left-right (l-r) asymmetry determination of organ systems in mammals. may play a role in endometrial bleeding.
3463	
3464	regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. forms complexes with beta-catenin and gamma-catenin/plakoglobin (by similarity).
3465	function in general translation initiation by promoting the binding of the formylmethionine-trna to ribosomes. seems to function along with eif-2.
3466	receptor for glutamate. l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists. this receptor binds domoate > kainate >> l-glutamate = quisqualate >> ampa = nmda.
3467	essential subunit of n-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide to an asparagine residue within an asn-x-ser/thr consensus motif in nascent polypeptide chains.
3468	
3469	
3470	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. the alpha and alpha@#$%& chains contain the catalytic site. participates in wnt signaling. ck2 phosphorylates ser-392 of p53/tp53 following uv irradiation.
3471	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
3472	
3473	
3474	
3475	required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (apc/c) and may confer substrate specificity upon the complex. is regulated by mad2l1. in metaphase the mad2l1-cdc20-apc/c ternary complex is inactive and in anaphase the cdc20-apc/c binary complex is active in degrading substrates.
3476	responsible for the synthesis of complex-type n-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. can produce lactose.
3477	
3478	
3479	
3480	
3481	
3482	
3483	receptor for members of the ephrin-a family. binds to ephrin-a1, -a3, -a4 and -a5.
3484	
3485	seems to act on cbl. may play a role in regulating the function of cbl and its associated protein kinases.
3486	
3487	
3488	probably plays a role in the formation and regulation of the tight junction (tj) paracellular permeability barrier.
3489	
3490	calcium-regulated non-lysosomal thiol-protease (by similarity).
3491	
3492	
3493	catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (srebps). other known substrates are bdnf and atf6.
3494	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. component of the iron-sulfur (ip) fragment of the enzyme.
3495	
3496	catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (srebps). other known substrates are bdnf and atf6.
3497	
3498	type i collagen is a member of group i collagen (fibrillar forming collagen).
3499	binds to and regulates the j and/or s elements in mhc ii promoter.
3500	this receptor binds polymeric iga and igm at the basolateral surface of epithelial cells. the complex is then transported across the cell to be secreted at the apical surface. during this process a cleavage occurs that separate the extracellular (known as the secretory component) from the transmembrane segment.
3501	ga733 tumor-associated antigen gene family may function as growth factor receptors.
3502	
3503	
3504	this protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. form i catalyzes the n-oxygenation of secondary and tertiary amines.
3505	
3506	
3507	
3508	
3509	functions as an e3-type small ubiquitin-like modifier (sumo) ligase, stabilizing the interaction between ube2i and the substrate, and as a sumo-tethering factor. plays a crucial role as a transcriptional coregulation in various cellular pathways, including the stat pathway and the steroid hormone signaling pathway. the effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
3510	
3511	this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of sodium and potassium ions across the plasma membrane. this action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
3512	may play a role in the molecular organization of synapses and neuronal cell signaling. could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. may induce enrichment of psd-95/sap90 at the plasma membrane.
3513	
3514	collagen type iii occurs in most soft connective tissues along with type i collagen.
3515	
3516	segment polarity protein, functions together with arm to transduce the wingless (wg) signal. acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
3517	potentially plays a role in the ras signal transduction pathway. capable of suppressing v-ras transformation in vitro.
3518	potentially plays a role in the ras signal transduction pathway. capable of suppressing v-ras transformation in vitro.
3519	the function of brain maps is essentially unknown. phosphorylated map1b may play a role in the cytoskeletal changes that accompany neurite extension. possibly map1b binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules.
3520	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
3521	
3522	
3523	
3524	catalyzes the conversion of cortisol to the inactive metabolite cortisone. modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
3525	transfers 1,4-n-acetylgalactosamine (galnac) from udp- galnac to the nonreducing end of glucuronic acid (glcua). required for addition of the first galnac to the core tetrasaccharide linker and for elongation of chondroitin chains.
3526	
3527	catalyzes the transformation of the potent androgen dihydrotestosterone (dht) into the less active form, 5-alpha- androstan-3alpha,17beta-diol (3-alpha-diol). also has some 20- alpha-hydroxysteroid dehydrogenase activity. the biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
3528	
3529	
3530	
3531	cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton.
3532	
3533	displays phosphatase activity toward several substrates. the highest relative activity is toward erk1.
3534	
3535	
3536	
3537	
3538	binds directly to 26s ribosomal rna.
3539	component of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends. rpp38 may associate transiently with rnase p rna as a factor involved in the transport of h1 rna to the putative site of its assembly in the cell, the nucleolus.
3540	
3541	this is one of the five types (d1 to d5) of receptors for dopamine. the activity of this receptor is mediated by g proteins which inhibit adenylyl cyclase.
3542	
3543	component of the mrn complex, which plays a central role in double-strand break (dsb) repair, dna recombination, maintenance of telomere integrity and meiosis. the complex possesses single-strand endonuclease activity and double-strand- specific 3@#$%&-5@#$%& exonuclease activity, which are provided by mre11a. rad50 may be required to bind dna ends and hold them in close proximity. this could facilitate searches for short or long regions of sequence homology in the recombining dna templates, and may also stimulate the activity of dna ligases and/or restrict the nuclease activity of mre11a to prevent nucleolytic degradation past a given point. the complex may also be required for dna damage signaling via activation of the atm kinase. in telomeres the mrn complex may modulate t-loop formation.
3544	
3545	promotes cell death. successfully competes for the binding to bcl-x(l), bcl-2 and bcl-w, thereby affecting the level of heterodimerization of these proteins with bax. can reverse the death repressor activity of bcl-x(l), but not that of bcl-2 (by similarity). appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
3546	
3547	
3548	
3549	
3550	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
3551	
3552	
3553	
3554	
3555	3@#$%&-to-5@#$%& exoribonuclease specific for small oligoribonucleotides. active on small (primarily </=5 nucleotides in length) single-stranded rna and dna oligomers. may have a role for cellular nucleotide recycling.
3556	mediates homophilic cell-cell adhesion.
3557	may play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.
3558	
3559	
3560	
3561	
3562	
3563	
3564	involved in the wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with frizzled for wnt.
3565	
3566	shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
3567	the zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac.
3568	may bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. may be under transcriptional regulation of steroid hormones.
3569	binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (pcb) and weakly progesterone, potent inhibitor of phospholipase a2.
3570	
3571	
3572	the insulin-like growth factors possess growth-promoting activity. in vitro, they are potent mitogens for cultured cells. igf-ii is influenced by placental lactogen and may play a role in fetal development.
3573	
3574	
3575	
3576	
3577	
3578	
3579	
3580	
3581	mediates the na(+)-independent transport of organic anions such as taurocholate, the prostaglandins pgd2, pge1, pge2, leukotriene c4, thromboxane b2 and iloprost (by similarity).
3582	
3583	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
3584	
3585	
3586	
3587	
3588	co-chaperone of hsc70.
3589	
3590	
3591	could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.
3592	
3593	forms calcium-sensitive (by similarity) chloride channels. may conduct other physiologically significant anions such as bicarbonate (by similarity).
3594	
3595	
3596	
3597	selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
3598	plays a role as a receptor for the recognition of mhc class i hla-e molecules by nk cells and some cytotoxic t-cells.
3599	
3600	prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
3601	regulates the gdp/gtp exchange reaction of the rho proteins by inhibiting the dissociation of gdp from them, and the subsequent binding of gtp to them.
3602	
3603	
3604	
3605	acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (by similarity). functions as an estrogen receptor (er)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. competes with ncoa1 for modulation of er transcriptional activity. probably involved in regulating mitochondrial respiration activity and in aging.
3606	unknown.
3607	
3608	
3609	transcriptional activatory factor. may play a role in the control of cell proliferation.
3610	required for protein transport from the er to the golgi complex.
3611	
3612	
3613	enhances pdgfa-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of pdgfb (by similarity).
3614	may play a role in apoptosis.
3615	
3616	
3617	
3618	
3619	produced by lymphocytes activated by specific antigens or mitogens. ifn-gamma, in addition to having antiviral activity, has important immunoregulatory functions. it is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type i interferons.
3620	specifically binds to domain c of the tax-responsive enhancer element in the long terminal repeat of htlv-i.
3621	may act as a tumor suppressor.
3622	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
3623	
3624	
3625	in the intracellular compartments, may function as a channel or small molecule transporter.
3626	
3627	
3628	probable transcription factor.
3629	
3630	probable e3 ubiquitin ligase protein, which mediates ubiquitination and subsequent proteasomal degradation of target proteins. may function as a facilitator or regulator of transcriptional activation by myc. may have a role during synaptogenesis.
3631	may play a role in lymphocyte activation.
3632	involved in ubiquitination and subsequent proteasomal degradation of target proteins. plays a role in the polyubiquitination of cdt1 in response to radiation-induced dna damage.
3633	
3634	
3635	
3636	
3637	
3638	
3639	may function in membrane trafficking. exhibits calcium- dependent phospholipid binding properties. may have a role in synaptic plasticity (by similarity).
3640	may function in membrane trafficking. exhibits calcium- dependent phospholipid binding properties. may have a role in synaptic plasticity (by similarity).
3641	implicated in immunoproteasome assembly and required for efficient antigen processing. the pa28 activator complex enhances the generation of class i binding peptides by altering the cleavage pattern of the proteasome.
3642	implicated in immunoproteasome assembly and required for efficient antigen processing. the pa28 activator complex enhances the generation of class i binding peptides by altering the cleavage pattern of the proteasome.
3643	component of the fact complex, a general chromatin factor that acts to reorganize nucleosomes. the fact complex is involved in multiple processes that require dna as a template such as mrna elongation, dna replication and dna repair. during transcription elongation the fact complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. it facilitates the passage of rna polymerase ii and transcription by promoting the dissociation of one histone h2a-h2b dimer from the nucleosome, then subsequently promotes the reestablishement of the nucleosome following the passage of rna polymerase ii. transcription elongation is promoted by the repression of transcription initiation from cryptic sites. also acts in establishing transcription initiation complexes and promotes spt15/tbp-binding to a tata box. together with replication factor-a protein (rpa), fact may play a role in nucleosome deposition during dna replication.
3644	this is a non-secretory ribonuclease. it is a pyrimidine specific nuclease with a slight preference for u. cytotoxin and helminthotoxin. selectively chemotactic for dendritic cells. possesses a wide variety of biological activities.
3645	repairs oxidative dna damages in vitro. may have a role in protection against cell lethality and suppression of mutations. removes the blocking groups from the 3@#$%& termini of the dna strand breaks generated by ionizing radiations and bleomycin.
3646	repairs oxidative dna damages in vitro. may have a role in protection against cell lethality and suppression of mutations. removes the blocking groups from the 3@#$%& termini of the dna strand breaks generated by ionizing radiations and bleomycin.
3647	enzyme with a broad specificity.
3648	
3649	receptor for prostaglandin e2 (pge2). the activity of this receptor is mediated by g(s) proteins that stimulate adenylate cyclase. the subsequent raise in intracellular camp is responsible for the relaxing effect of this receptor on smooth muscle.
3650	
3651	
3652	major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
3653	receptor for extracellular atp > utp and adp. the activity of this receptor is mediated by g proteins which activate a phosphatidylinositol-calcium second messenger system. may be the cardiac p2y receptor involved in the regulation of cardiac muscle contraction through modulation of l-type calcium currents. is a receptor for leukotriene b4, a potent chemoattractant involved in inflammation and immune response.
3654	promotes adhesion of endothelial cells through interaction of integrins and the rgd motif. could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling.
3655	
3656	required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors. may bind a rab gtpase such as vps21.
3657	
3658	may function as a phosphatase involved in the regulation of cell growth and differentiation.
3659	converts d-glucuronic acid residues adjacent to n- sulfate sugar residues to l-iduronic acids (by similarity).
3660	probably plays a role in cartilage scaffolding. may act by antagonizing tgf-beta1 (tgfb1) and igf1 functions. has the ability to suppress igf1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced igf1r autophosphorylation. may inhibit tgfb1-mediated induction of cartilage matrix genes via its interaction with tgfb1. overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (ppi) supersaturation in aging and osteoarthritis cartilage.
3661	likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the rx(k/r)r consensus motif.
3662	forms critical branches in o-glycans.
3663	
3664	
3665	
3666	retards apoptosis induced by il-3 deprivation. may function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (by similarity).
3667	
3668	specifically phosphorylates tyr-504 on lck, which acts as a negative regulatory site. can also act on the lyn and fyn kinases.
3669	
3670	
3671	
3672	
3673	ubiquitin ligase protein which is a component of the n- end rule pathway. recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the n-end rule, leading to their ubiquitination and subsequent degradation.
3674	
3675	
3676	
3677	major role in the synthesis of nucleoside triphosphates other than atp. the atp gamma phosphate is transferred to the ndp beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
3678	performs the first committed step in the biosynthesis of isoprenes.
3679	
3680	plays a role in the toxic effects of organotins.
3681	
3682	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
3683	type i collagen is a member of group i collagen (fibrillar forming collagen).
3684	
3685	transcription activator that binds dna cooperatively with dp proteins through the e2 recognition site, 5@#$%&-tttc[cg]cgc- 3@#$%& found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the drtf1/e2f complex functions in the control of cell-cycle progression from g1 to s phase. e2f-4 binds with high affinity to p107 and p130. in some instances, can also bind rb protein.
3686	serum albumin, the main protein of plasma, has a good binding capacity for water, ca(2+), na(+), k(+), fatty acids, hormones, bilirubin and drugs. its main function is the regulation of the colloidal osmotic pressure of blood.
3687	
3688	
3689	
3690	part of pre- and post-splicing multiprotein mrnp complexes. enhances the formation of the atp-dependent a complex of the spliceosome. involved in both constitutive splicing and, in association with srp54 and sfrs10, in distinctive modulation of alternative splicing in a substrate-dependent manner. participates in mrna 3@#$%&end cleavage. involved in rent2-dependent nonsense- mediated decay (nmd) of mrnas containing premature stop codons. also mediates increase of mrna abundance and translational efficiency. binds spliced mrna 20-25 nt upstream of exon-exon junctions.
3691	
3692	involved in endosome dynamics. may coordinate membrane transport with the function of the cytoskeleton. participates in reorganization of actin cytoskeleton (by similarity).
3693	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
3694	potential central metabolic regulator.
3695	
3696	may be involved in calcium dependent neurotransmitter release through the interaction with unc13a. may be involved in dynein-dependent intracellular vesicle transport. in vitro, binds calcium and phospholipids.
3697	required for rna polymerase iii-mediated transcription. component of tfiiic that initiates transcription complex assembly on trna and is required for transcription of 5s rrna and other stable nuclear and cytoplasmic rnas. binds to the box b promoter element.
3698	
3699	
3700	ca(2+)-dependent modulation of synaptic efficacy.
3701	
3702	essential for biological clock functions. determines the period length of circadian and ultradian rhythms; an increase in per dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. the biological cycle depends on the rhythmic formation and nuclear localization of the tim-per complex. light induces the degradation of tim, which promotes elimination of per. nuclear activity of the heterodimer coordinatively regulates per and tim transcription through a negative feedback loop. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition.
3703	potentially involved in docking of synaptic vesicles at presynaptic active zones (by similarity).
3704	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
3705	
3706	
3707	histone h3, along with histone h4, plays a central role in nucleosome formation.
3708	catalyzes the n-acetylation of serotonin into n- acetylserotonin.
3709	protease with a carboxypeptidase b-like function involved in killer toxin and alpha-factor precursor processing.
3710	
3711	
3712	
3713	
3714	
3715	atp-dependent rna helicase involved nonsense-mediated mrna decay and ribosome biogenesis through rrna processing.
3716	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2). icam2 may play a role in lymphocyte recirculation by blocking lfa-1-dependent cell adhesion. it mediates adhesive interactions important for antigen- specific immune response, nk-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
3717	exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper b into subunit i (by similarity).
3718	
3719	may participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. transports glutathione conjugates as leukotriene-c4 (ltc4) and n-ethylmaleimide s-glutathione (nem-gs).
3720	
3721	tubulin is the major constituent of microtubules. gamma tubulin is found at microtubule organizing centers (mtoc) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
3722	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
3723	acts as a transcriptional activator of the c-myc gene; binds dna nonspecifically (ref.3).
3724	type i collagen is a member of group i collagen (fibrillar forming collagen).
3725	histone acetyltransferase which specifically represses ar-mediated transcription. may play a role in dna replication.
3726	chemoattractant for blood monocytes, memory t-helper cells and eosinophils. causes the release of histamine from basophils and activates eosinophils. binds to ccr1, ccr3, ccr4 and ccr5. one of the major hiv-suppressive factors produced by cd8+ t- cells. recombinant rantes protein induces a dose-dependent inhibition of different strains of hiv-1, hiv-2, and simian immunodeficiency virus (siv). the processed form rantes(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of hiv-1-infection. the second processed form rantes(4-68) exhibits reduced chemotactic and hiv-suppressive activity compared with rantes(1-68) and rantes(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.
3727	
3728	
3729	
3730	seems to act exclusively upon threonine residues (by similarity).
3731	protein transport. probably involved in vesicular traffic (by similarity).
3732	oxygenase and 14,15-leukotriene a4 synthase activity.
3733	oxygenase and 14,15-leukotriene a4 synthase activity.
3734	essential component of nuclear pore complex.
3735	implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2a, regulation of mrna trafficking and stability in association with elavl1, and inhibition of acetyltransferases as part of the inhat (inhibitor of histone acetyltransferases) complex (by similarity).
3736	
3737	
3738	splice factor that is required for the first atp- dependent step in spliceosome assembly and for the interaction of u2 snrnp with the branchpoint. has weak rna-dependent atpase activity. required for mrna export.
3739	
3740	
3741	terminates the action of serotonine by its high affinity sodium-dependent reuptake into presynaptic terminals.
3742	
3743	essential for the degradation of glygogen to glucose in lysosomes.
3744	may be involved in transcriptional regulation.
3745	seems to play a negative regulatory role in prpp synthesis.
3746	
3747	
3748	can activate specifically hydrolysis of gtp bound to rac1 and cdc42, but not rala. mediates atp-dependent transport of s-(2,4-dinitrophenyl)-glutathione (dnp-sg) and doxorubicin (dox) and is the major atp-dependent transporter of glutathione conjugates of electrophiles (gs-e) and dox in erythrocytes. can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon.
3749	
3750	
3751	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
3752	
3753	
3754	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
3755	
3756	
3757	inhibits urokinase-type plasminogen activator. the monocyte derived pai-2 is distinct from the endothelial cell- derived pai-1.
3758	
3759	
3760	may be involved in transcriptional regulation.
3761	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
3762	mediates estrogen action in various target organs.
3763	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
3764	
3765	
3766	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2). icam3 is also a ligand for integrin alpha-d/beta-2.
3767	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2).
3768	catalyzes electron transfer from reduced pyridine nucleotides to flavins as well as methylene blue, pyrroloquinoline quinone, riboflavin, or methemoglobin. possible role in protecting cells from oxidative damage or in regulating iron metabolism. in the liver, converts biliverdin to bilirubin.
3769	
3770	
3771	
3772	this receptor has essential roles in the regulation of ige production and in the differentiation of b-cells (it is a b- cell-specific antigen).
3773	
3774	
3775	
3776	targets myosin phosphatase to the actin cytoskeleton. required for the regulation of the actin cytoskeleton by rhoa and rock1. depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. overexpression of mrip as well as its f- actin-binding region leads to disassembly of stress fibers in neuronal cells.
3777	may be involved in desquamation.
3778	stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. acts synergistically with other cytokines, including il-3, gcsf, gmcsf and flt3 ligand. suppresses scf-stimulated erythrocyte proliferation.
3779	
3780	
3781	
3782	
3783	
3784	nmda receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine.
3785	
3786	promotes intergrin-mediated cell adhesion. may stimulate host defense against viruses and tumor cells.
3787	
3788	may play a role in the regulation of rna biogenesis and/or mitosis. in vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone h1.
3789	component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to atp synthesis.
3790	cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the peyer patches and the intestinal lamina propria. it can bind both integrin alpha-4/beta-7 and l-selectin, regulating both the passage and retention of leukocytes. isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of l- selectin binding.
3791	required for fusion of er-derived vesicles with the golgi during er-to-golgi protein transport. may be involved in proper membrane localization of rab gtpases.
3792	
3793	transcriptional corepressor that binds to a number of transcription factors. inhibits the transcriptional activation mediated by ctnnb1 and tcf family members in wnt signaling. the effects of full-length tle family members may be modulated by association with dominant-negative aes (by similarity).
3794	
3795	
3796	acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. one of the activated genes is an inhibitor of cyclin-dependent kinases. apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of bcl-2 expression.
3797	this is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. binds heparin. the cytotoxic action is limited to many species of gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic n-terminal half for the negatively charged lipopolysaccharides that are unique to the gram-negative bacterial outer envelope. it may play a role in mediating recruitment of monocytes in the second wave of inflammation.
3798	
3799	
3800	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
3801	p65 is a subunit of the nuclear factor kappa-b, a second messenger, which activates the transcription of a number of genes in multiple tissues. the inhibitory effect of i-kappa-b upon nf- kappa-b in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak dna-binding site which could contribute directly to dna binding in the nf-kappa-b complex.
3802	transcription factor that binds to a symmetrical dna sequence (e-boxes) (5@#$%&-cacgtg-3@#$%&) that is found in a variety of viral and cellular promoters.
3803	may modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (ng-cam and n-cam). chondroitin sulfate proteoglycan; binds to hyaluronic acid.
3804	capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.
3805	isomerization of 3-trans,5-cis-dienoyl-coa to 2-trans,4- trans-dienoyl-coa (by similarity).
3806	transcriptional repressor.
3807	
3808	
3809	hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate.
3810	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
3811	
3812	
3813	
3814	
3815	
3816	inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. inhibins appear to oppose the functions of activins.
3817	
3818	
3819	enzyme which catalyzes the acetylation of polyamines. substrate specificity: norspermidine = spermidine >> spermine > n(1)acetylspermine > putrescine. this highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. also involved in the regulation of polyamine transport out of cells (by similarity).
3820	
3821	la protein plays a role in the transcription of rna polymerase iii. it is most probably a transcription termination factor. binds to the 3@#$%& termini of virtually all nascent polymerase iii transcripts. it is associated with precursor forms of rna polymerase iii transcripts including trna and 4.5s, 5s, 7s, and 7-2 rnas.
3822	
3823	when phosphate concentrations are high it phosphorylates the pho4 transcription factor thus establishing repression.
3824	
3825	
3826	
3827	chaperone necessary for the assembly of mitochondrial respiratory chain complex iii.
3828	the intermediate chains seem to help dynein bind to dynactin 150 kda component.
3829	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
3830	
3831	
3832	
3833	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
3834	
3835	component of the 60-80s u3 small nucleolar ribonucleoprotein (u3 snornp). required for the early cleavages during pre-18s ribosomal rna processing.
3836	
3837	may be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. augments cytokine-mediated stat transcription. enhances cbp/p300 coactivator protein recruitment to stat1 and stat5.
3838	
3839	
3840	
3841	
3842	protein transport. regulator of membrane traffic from the golgi apparatus towards the endoplasmic reticulum (er). has a low gtpase activity.
3843	acts as a regulator of traf function by maintaining them in a latent state. overexpression inhibits traf2-mediated nf- kappa-b activation signaled by cd40, tnfr1 and tnfr2. blocks traf2 binding to lmp1 and inhibits lmp1-mediated nf-kappa-b activation.
3844	
3845	
3846	type i collagen is a member of group i collagen (fibrillar forming collagen).
3847	straight-chain enoyl-coa thioesters from c4 up to at least c16 are processed, although with decreasing catalytic rate.
3848	straight-chain enoyl-coa thioesters from c4 up to at least c16 are processed, although with decreasing catalytic rate.
3849	
3850	acts as a positive regulator of apoptosis.
3851	
3852	
3853	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. may be implicated in the folding, transport, and assembly of proteins. may play an important role in the regulation of pre-mrna splicing.
3854	required for 60s ribosomal subunit biogenesis (by similarity).
3855	
3856	
3857	
3858	required for genome wide de novo methylation and is essential for development.
3859	may play a role in the recruitment of beta-1 integrins to the focal contacts during integrin-dependent cell adhesion. isoform 2 does not bind the integrin cytoplasmic domain-associated protein-1.
3860	may be involved in the regulation of gene expression by covalent modification of histone proteins. the long isoform is a corepressor of estrogen receptor (er). the short isoform binds to er and sequesters it in the cytoplasm and enhances non-genomic responses of er.
3861	interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. the interaction is mediated by the sh2 domain (by similarity).
3862	involved in pre-mrna splicing.
3863	
3864	may be involved in several stages of intracellular trafficking (by similarity).
3865	
3866	
3867	induces cartilage and bone formation. may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. plays a role in calcium regulation and bone homeostasis.
3868	thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of cox.
3869	may play a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. there are four molecules of fkbp12 per skeletal muscle ryr. ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
3870	associated with snrnp u1, u2, u4/u6 and u5. may have a functional role in the pre-mrna splicing or in snrnp structure.
3871	
3872	provides cdp-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.
3873	has 2-hydroxyacid oxidase activity. most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids.
3874	may be involved in transcriptional regulation as a repressor.
3875	
3876	may be involved in transcriptional regulation.
3877	
3878	netrins control guidance of cns commissural axons and peripheral motor axons. its association with either dcc or some unc5 receptors will lead to axon attraction or repulsion, respectively. it also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. involved in colorectal tumorigenesis by regulating apoptosis.
3879	
3880	probably involved in formation of autophagosomal vacuoles (autophagosomes).
3881	may function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
3882	
3883	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex. f6 seems to be part of the stalk that links cf(0) to cf(1). also involved in the restoration of oligomycin-sensitive atpase activity to depleted f1-f0 complexes.
3884	destroys radicals which are normally produced within the cells and which are toxic to biological systems.
3885	
3886	ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. modulates the gating kinetics and enhances stability of the channel complex. assembled with kcnq1/kvlqt1 is proposed to form the slowly activating delayed rectifier cardiac potassium (iks) channel. the outward current reaches its steady state only after 50 seconds. assembled with kcnh2/herg may modulate the rapidly activating component of the delayed rectifying potassium current in heart (ikr).
3887	
3888	
3889	this is an intracellular thiol proteinase inhibitor. tightly binding reversible inhibitor of cathepsins l, h and b.
3890	
3891	the major proteolytic product p15 bid allows the release of cytochrome c (by similarity). isoform 1, isoform 2 and isoform 4 induce ice-like proteases and apoptosis. isoform 3 does not induce apoptosis. counters the protective effect of bcl-2.
3892	promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, aes and tle1.
3893	could have a part in mechanisms of transcriptional regulation similar to that played by yeast hir1 and hir2 together.
3894	type i collagen is a member of group i collagen (fibrillar forming collagen).
3895	may function as a transcription factor.
3896	
3897	
3898	
3899	
3900	
3901	promotes guanine-nucleotide exchange on arf1 and arf5. promotes the activation of arf through replacement of gdp with gtp.
3902	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
3903	
3904	rna-dependent atpase activity. the rate of atp hydrolysis is highly stimulated by single-stranded rna.
3905	responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. it is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
3906	
3907	
3908	
3909	
3910	
3911	thiol protease. has dipeptidylpeptidase activity. can act as both an exopeptidase and endopeptidase. activates serine proteases such as elastase, cathepsin g and granzymes a and b. can also activate neuraminidase and factor xiii.
3912	may play a role in the regulation of pre-mrna splicing.
3913	epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.
3914	transcriptional repressor that play an important role in the specification and differentiation of lung epithelium.
3915	
3916	
3917	this protein promotes the gtp-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome.
3918	seems to act exclusively upon threonine residues (by similarity).
3919	involved in mediating u snrna export from the nucleus. binds to 5@#$%& capped mrna.
3920	
3921	implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. may be involved in the regulation of perinuclear intravesicular membrane traffic (by similarity).
3922	catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
3923	the long isoform may play a role in neural and glial cell adhesion in the developing embryo. the short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. vital for embryonic development. essential for septate junctions. septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. required for the blood-brain barrier formation.
3924	specifically promotes functional cell surface expression of olfactory receptors, but not of other gpcrs (by similarity).
3925	
3926	favors the reduction of estrogens and androgens. also has 20-alpha-hsd activity. uses preferentially nadh.
3927	
3928	involved in n-linked oligosaccharide assembly. required for the translocation of man(5)glcnac(2)-pp-dolichol from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.
3929	
3930	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
3931	
3932	sodium-dependent amino acid/proton antiporter. mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. also recognizes histidine, asparagine and alanine. may mediate amino acid transport in either direction under physiological conditions. may play a role in nitrogen metabolism and synaptic transmission.
3933	
3934	promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. shows affinity for calcium and barium ions.
3935	
3936	involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. it n-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. acts on tma to produce tma-n-oxide.
3937	involved in the costimulatory signal essential for t- lymphocyte activation. t-cell proliferation and cytokine production is induced by the binding of cd28 or ctla-4 to this receptor.
3938	regulatory light chain of myosin. does not bind calcium.
3939	
3940	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
3941	
3942	
3943	strong inhibitor of acrosin in male and/or female genital tract. also inhibits trypsin.
3944	associates with cyclin g and cdk5. seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by hsc70 in non-neuronal cells. expression oscillates slightly during the cell cycle, peaking at g1.
3945	
3946	
3947	chemotactic for neutrophil granulocytes.
3948	binds preferentially single-stranded dna and unwinds double stranded dna.
3949	may control the level of the estrogen receptor by sulfurylating free estradiol. maximally sulfates beta-estradiol and estrone at concentrations of 20 nm. also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.
3950	receptor for gonadotropin releasing hormone (gnrh) that mediate the action of gnrh to stimulate the secretion of the gonadotropic hormones (lh and fsh). this receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system. isoform 2 may act a an inhibitor of gnrh-r signaling.
3951	
3952	
3953	
3954	probably catalyzes the first step in biosynthesis of glycosaminoglycan. transfers d-xylose from udp-d-xylose to specific serine residues of the core protein. initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (by similarity). its enzyme activity has not been demonstrated.
3955	may act as a gtpase activating protein for rab family protein(s).
3956	may act as a gtpase activating protein for rab family protein(s).
3957	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
3958	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
3959	inhibitor of wnt signaling pathway (potential).
3960	
3961	receptor for steroids (potential).
3962	
3963	receptor for neuropeptide y and peptide yy.
3964	removes the amino-terminal methionine from nascent proteins (by similarity).
3965	
3966	may be involved in transcriptional regulation.
3967	may play a role in cell proliferation.
3968	egf stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture.
3969	
3970	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
3971	
3972	
3973	encodes an essential ribose methyltransferase that specifically modifies to 2@#$%&-o-methylguanosine a universally conserved nucleotide, g-2270, in the peptidyl transferase center of the mitochondrial large ribosomal rna (21s). this modification seems to be important for the normal accumulation of this latter 21s subunit.
3974	beta-hexosaminidase a is responsible for the degradation of gm2 gangliosides, and a variety of other molecules containing terminal n-acetyl hexosamines, in the brain and other tissues.
3975	aminopeptidase n is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
3976	
3977	isoform 2 up-regulates the production of ghbp and acts as a negative inhibitor of gh signaling.
3978	functions in nuclear protein import as nuclear transport receptor. serves as receptor for nuclear localization signals (nls) in cargo substrates. is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (npc) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus (by similarity). involved in nuclear import of m9- containing proteins. in vitro, binds directly to the m9 region of the heterogeneous nuclear ribonucleoproteins (hnrnp), a1 and a2 and mediates their nuclear import. appears also to be involved in hnrnp a1/a2 nuclear export. mediates the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones, and srp19.
3979	
3980	
3981	
3982	
3983	sodium-ion dependent, low affinity carnitine transporter. probably transports one sodium ion with one molecule of carnitine. also transports organic cations such as tetraethylammonium (tea) without the involvement of sodium. relative uptake activity ratio of carnitine to tea is 1.78. a key substrate of this transporter seems to be ergothioneine (et).
3984	
3985	
3986	
3987	may behave as an activator of the bound transcription factor, mybl2, and be involved in embryonic development.
3988	
3989	
3990	the glycine receptor is a neurotransmitter-gated ion channel. binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
3991	drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively. binds f-actin.
3992	
3993	
3994	
3995	
3996	muscle contraction.
3997	does not seem to have ndk kinase activity. confers protection from cell death by bax and alters the cellular levels of several antioxidant enzymes including gpx5. may play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (by similarity).
3998	
3999	functions in nuclear protein import as an adapter protein for nuclear receptor kpnb1. binds specifically and directly to substrates containing either a simple or bipartite nls motif. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. mediates nuclear import of stat1 homodimers and stat1/stat2 heterodimers by recognizing nonclassical nlss of stat1 and stat2 through arm repeats 8-9. recognizes influenza a virus nucleoprotein through arm repeat 7-9 in vitro, mediates the nuclear import of human cytomegalovirus ul84 by recognizing a nonclassical nls.
4000	atp-dependent rna helicase involved nonsense-mediated mrna decay and ribosome biogenesis through rrna processing.
4001	transcriptional activator; dna-binding protein that specifically recognize the sequence 5@#$%&-yaac[gt]g-3@#$%&. plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
4002	dna-binding protein involved in cell cycle control. may act as a transcription activator. also seems to be involved in the second catalytic step of pre-mrna splicing.
4003	
4004	transcriptional activator. binds to the interferon- stimulated response element (isre) of the mhc class i promoter. binds the immunoglobulin lambda light chain enhancer, together with pu.1. probably plays a role in isre-targeted signal transduction mechanisms specific to lymphoid cells.
4005	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
4006	
4007	
4008	
4009	
4010	may be involved in transcriptional regulation.
4011	may be involved in transcriptional regulation.
4012	
4013	cytokine that in its homotrimeric form binds to tnfrsf1a/tnfr1, tnfrsf1b/tnfbr and tnfrsf14/hvem. in its heterotrimeric form with ltb binds to tnfrsf3/ltbr. lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
4014	factor b which is part of the alternate pathway of the complement system is cleaved by factor d into 2 fragments: ba and bb. bb, a serine protease, then combines with complement factor 3b to generate the c3 or c5 convertase.
4015	
4016	
4017	appears to mediate interactions between cells and the extracellular matrix. substrate-adhesion molecule that appears to inhibit cell migration. may play a role in supporting the growth of epithelial tumors.
4018	
4019	
4020	
4021	receptor for somatostatin-28. the activity of this receptor is mediated by g proteins which inhibit adenylyl cyclase.
4022	snare that acts to regulate protein transport between late endosomes and the trans-golgi network.
4023	
4024	
4025	
4026	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity.
4027	
4028	positive modulator of atm response to dna damage.
4029	able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-coa species.
4030	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form.
4031	stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers (by similarity).
4032	has a broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. can hydrolyze nucleoside 5@#$%& triphosphates such as atp, gtp, ctp, ttp and utp to their corresponding monophosphates with release of pyrophosphate. can hydrolyze diadenosine polyphosphates and 3@#$%&,5@#$%&-camp to amp. it may play a role in the regulation of pyrophosphate production, the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and golgi, and the regulation of purinergic signaling.
4033	involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. may play a role in the specification or differentiation of one or more subsets of epicardial cell types.
4034	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
4035	receptor for the lysosphingolipid sphingosine 1- phosphate (s1p). s1p is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. this receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system (by similarity).
4036	
4037	this protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (gpi-anchor) thus releasing these proteins from the membrane.
4038	transport of phosphorylated lysosomal enzymes from the golgi complex and the cell surface to lysosomes. lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low ph mediates the dissociation of the complex. this receptor also binds igf2.
4039	
4040	
4041	
4042	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
4043	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
4044	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
4045	
4046	
4047	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. may catalyze basal processing of intracellular antigens.
4048	
4049	this is a receptor for pacap-27 and pacap-38. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase. may regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. may play a role in spermatogenesis and sperm motility. causes smooth muscle relaxation and secretion in the gastrointestinal tract.
4050	binds to the camp response element and activates transcription.
4051	
4052	ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. in vitro, also has barbed end capping and nucleating activities in the presence of ca(2+).
4053	
4054	
4055	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
4056	
4057	
4058	
4059	rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. it may also have a role in the development of malignancy and the growth progression of some tumors.
4060	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
4061	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
4062	
4063	
4064	receptor for members of the ephrin-a family. binds with a low affinity to ephrin-a1.
4065	collagen type iii occurs in most soft connective tissues along with type i collagen.
4066	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
4067	
4068	
4069	
4070	
4071	
4072	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
4073	
4074	may be involved in transcriptional regulation.
4075	inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme.
4076	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
4077	plays a role in papillomavirus genes transcription.
4078	may play a role in reproduction.
4079	
4080	calcium-dependent, calmodulin-stimulated protein phosphatase. this subunit may have a role in the calmodulin activation of calcineurin.
4081	
4082	this is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
4083	
4084	
4085	
4086	transcription factor, which binds preferentially the consensus sequence 5@#$%&-taagt[ag]-3@#$%& and can behave as a transcriptional repressor. could play an important role in regulating proliferation of glandular epithelium and in the formation of ducts in prostate.
4087	
4088	seems to function as an adapter protein. in adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. seems to couple transcription factor sox4 to the il-5 receptor (il5ra). may also play a role in vesicular trafficking. seems to be required for the targeting of tgfa to the cell surface in the early secretory pathway.
4089	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
4090	
4091	
4092	has antibacterial activity (potential).
4093	hcnp may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. hcnp increases the production of choline acetyltransferase but not acetylcholinesterase. seems to be mediated by a specific receptor (by similarity).
4094	functions as a component of the nuclear pore complex (npc). npc components, collectively referred to as nucleoporins (nups), can play the role of both npc structural components and of docking or interaction partners for transiently associated nuclear transport factors. active directional transport is assured by both, a phe-gly (fg) repeat affinity gradient for these transport factors across the npc and a transport cofactor concentration gradient across the nuclear envelope (gsp1 and gsp2 gtpases associated predominantly with gtp in the nucleus, with gdp in the cytoplasm). nup116 plays an important role in several nuclear export and import pathways including poly(a)+ rna, trna, preribosome, and protein transport.
4095	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
4096	
4097	
4098	
4099	
4100	guanine nucleotide exchange factor (gef) for rab-3 and cab-1. novel regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release. is also a regulator of the cab-1 synaptic transmission pathway.
4101	
4102	
4103	hydrolyzes adenosine 5@#$%&-monophosphoramidate substrates such as amp-morpholidate, amp-n-alanine methyl ester, amp-alpha- acetyl lysine methyl ester and amp-nh2 (by similarity).
4104	reversible hydration of carbon dioxide. may be involved in the control of cell proliferation and transformation. appears to be a novel specific biomarker for a cervical neoplasia.
4105	
4106	functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-pge1, 15-oxo-pge2 and 15-oxo-pge2alpha. has no activity towards pge1, pge2 and pge2alpha (by similarity). catalyzes the conversion of leukotriene b4 into its biologically less active metabolite, 12-oxo-leukotriene b4. this is an initial and key step of metabolic inactivation of leukotriene b4.
4107	
4108	
4109	
4110	sam (substrate-adhesion molecule) that appears to inhibit cell migration. may play a role in supporting the growth of epithelial tumors. is a ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-v/beta-3 and alpha-v/beta-6.
4111	involved in serum exerting lectin activity. binds glcnac.
4112	
4113	may be required for testis development.
4114	
4115	
4116	involved in the maturation of asn-linked oligosaccharides. trim a single alpha-1,2-linked mannose residue from man(9)glcnac(2) to produce man(8)glcnac(2). the only product is the man(8)glcnac(2) isomer b, the form lacking the middle-arm terminal alpha 1,2-mannose. it may be involved in glycoprotein quality control since it is important to target misfolded glycoproteins for degradation.
4117	required for normal renal development and establishment of left-right axis. probably acts as a molecular switch between different wnt signaling pathways. inhibits the canonical wnt pathway by targeting cytoplasmic disheveled (dvl1) for degradation by the ubiquitin-proteasome. this suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by wnt signaling.
4118	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
4119	
4120	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&. activates transcription of pf4 in complex with meis1.
4121	forms a channel for water and glycerol.
4122	
4123	
4124	member of the cyclin-dependent kinase pair (cdk9/cyclin- t) complex, also called positive transcription elongation factor b (p-tefb), which facilitates the transition from abortive to production elongation by phosphorylating the ctd (c-terminal domain) of the large subunit of rna polymerase ii (rnap ii), supt5h and rdbp. the cdk9/cyclin-k complex has also a kinase activity toward ctd of rnap ii and can substitute for p-tefb in vitro.
4125	collagen type iv is specific for basement membranes.
4126	has a role in the negative regulation of gluconeogenesis. required for proteosome-dependent catabolite degradation of fructose-1,6-bisphosphatase (fbpase). accelerates proteosomal breakdown of ubiquitinated proteins as it disassembles free ubiquitin chains that would compete with ubiquitinated proteins to bind to the proteosome.
4127	molecular chaperone; assists the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
4128	implicated in the control of cell fate decisions during development.
4129	putative function in synaptic vesicle exocytosis by binding to stxbp1, an essential component of the synaptic vesicle exocytotic machinery. may modulate processing of the beta-amyloid precursor protein (app) and hence formation of beta-app.
4130	interconversion of serine and glycine.
4131	possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
4132	
4133	
4134	tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. it seems to be required for cartilage and growth plate development.
4135	
4136	
4137	
4138	regulates the levels of camp in the cell.
4139	atp-dependent 5@#$%&-3@#$%& dna helicase, component of the core- tfiih basal transcription factor. involved in nucleotide excision repair (ner) of dna by opening dna around the damage, and in rna transcription by rna polymerase ii by anchoring the cdk-activating kinase (cak) complex, composed of cdk7, cyclin h and mat1, to the core-tfiih complex. might also have a role in aging process and could play a causative role in the generation of skin cancers.
4140	
4141	
4142	
4143	
4144	binds to an err-alpha response element (erre) containing a single consensus half-site, 5@#$%&-tnaaggtca-3@#$%&. can bind to the medium-chain acyl coenzyme a dehydrogenase (mcad) response element nrre-1 and may act as an important regulator of mcad promoter. binds to the c1 region of the lactoferrin gene promoter.
4145	transcription factor that binds to sequence with multiple copies of ttc[cg]g present in its own promoter and that of the hnrpa2b1 gene. down-regulates transcription of these genes. binds to the retinoic acid response element (rare) agggttcaccgaaagttca. activates the proenkephalin gene independently of promoter binding, probably through protein- protein interaction. when secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the g0 or g1 phase.
4146	this protein mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. it is a tetrodotoxin-resistant sodium channel isoform. its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). plays a role in neuropathic pain mechanisms (by similarity).
4147	has greatest activity toward short branched chain acyl- coa derivative such as (s)-2-methylbutyryl-coa, isobutyryl-coa, and 2-methylhexanoyl-coa as well as toward short straight chain acyl-coas such as butyryl-coa and hexanoyl-coa. can use valproyl- coa as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent.
4148	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
4149	
4150	
4151	essential component of the cop9 signalosome complex (csn), a complex involved in various cellular and developmental processes. the csn complex is an essential regulator of the ubiquitin (ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of scf-type e3 ligase complexes, leading to decrease the ubl ligase activity of scf-type complexes such as scf, csa or ddb2. the complex is also involved in phosphorylation of p53/tp53, c-jun/jun, ikappabalpha/nfkbia, itpk1 and irf8/icsbp, possibly via its association with ck2 and pkd kinases. csn- dependent phosphorylation of tp53 and jun promotes and protects degradation by the ubl system, respectively. suppresses g-protein- and mitogen-activated protein kinase-mediated signal transduction.
4152	regulatory subunit of the calcium activated potassium kcnma1 (maxik) channel. modulates the calcium sensitivity and gating kinetics of kcnma1, thereby contributing to kcnma1 channel diversity. acts as a negative regulator that confers rapid and complete inactivation of kcnma1 channel complex. may participate in kcnma1 inactivation in chromaffin cells of the adrenal gland or in hippocampal ca1 neurons.
4153	
4154	
4155	
4156	not known. may play a role in regulating the circulating activity of cytokines as it binds to il-1, il-2 and tnf with high affinity.
4157	
4158	
4159	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
4160	regulates beta-adrenergic receptor function. beta- arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate g(s) proteins.
4161	potential calcium-dependent cell-adhesion protein.
4162	
4163	
4164	may be involved in transcriptional regulation.
4165	probably involved in synaptic functions in the cns.
4166	
4167	
4168	
4169	part of the ap-3 complex, an adaptor-related complex which is not clathrin-associated. the complex is associated with the golgi region as well as more peripheral structures. it facilitates the budding of vesicles from the golgi membrane and may be directly involved in trafficking to lysosomes.
4170	
4171	mediates hepatobiliary excretion of numerous organic anions. may function as a cellular cisplatin transporter.
4172	
4173	may facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery.
4174	
4175	may be required for polarization of epithelia (by similarity).
4176	
4177	
4178	associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mrna splicing (by similarity).
4179	
4180	
4181	
4182	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
4183	
4184	
4185	gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. it also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
4186	
4187	
4188	may play a key role in signal transduction and growth control.
4189	calcium-dependent mitochondrial solute carrier (by similarity).
4190	rna and ssdna-binding protein that may play specific roles during transcription initiation at distinct promoters. can enter the preinitiation complex together with the rna polymerase ii (pol ii).
4191	involved in stabilization of lens fiber cell cytoskeleton (by similarity).
4192	calcium-dependent and glcnac-binding lectin. enhanced phagocytosis of s.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region (by similarity).
4193	identifies cytotoxic/suppressor t-cells that interact with mhc class i bearing targets. cd8 is thought to play a role in the process of t-cell mediated killing.
4194	participates in dna repair and in chromosomal dna replication.
4195	transcriptional modulator activated by tgf-beta and activin type 1 receptor kinase. smad2 is a receptor-regulated smad (r-smad). may act as a tumor suppressor in colorectal carcinoma.
4196	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.
4197	required for dna replication. plays a role in the rescue of stalled replication forks and checkpoint control. binds double- stranded dna breaks and nicks as well as single-stranded dna. recruits the swi/snf chromatin remodeling complex to e2f1- responsive promoters. down-regulates e2f1 activity and inhibits e2f1-dependent apoptosis during g1/s transition and after dna damage. induces a large increase in the kinase activity of atr.
4198	inhibitor of the wnt signaling pathway. down-regulates beta-catenin. probably facilitate the phosphorylation of beta- catenin and apc by gsk3b (by similarity).
4199	growth factor for endothelial cells. vegf-b167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of vegf-b186 is regulated by proteolysis.
4200	cross-linked envelope protein of keratinocytes. it is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. all that results in the formation of an insoluble envelope beneath the plasma membrane. can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage.
4201	
4202	
4203	common mediator of signal transduction by tgf-beta (transforming growth factor) superfamily; smad4 is the common smad (co-smad). promotes binding of the smad2/smad4/fast-1 complex to dna and provides an activation function required for smad1 or smad2 to stimulate transcription. may act as a tumor suppressor.
4204	
4205	unknown. the presence of the putative catalytic domain of s-adenosyl-l-methionine binding argues for a methyltransferase activity.
4206	unknown. the presence of the putative catalytic domain of s-adenosyl-l-methionine binding argues for a methyltransferase activity.
4207	
4208	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1b gives rise to n-type calcium currents. n-type calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group and are blocked by omega-conotoxin-gvia (omega-ctx-gvia) and by omega-agatoxin- iiia (omega-aga-iiia). they are however insensitive to dihydropyridines (dhp), and omega-agatoxin-iva (omega-aga-iva). calcium channels containing alpha-1b subunit may play a role in directed migration of immature neurons.
4209	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
4210	
4211	phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin i. the alpha chain may bind calmodulin.
4212	probable transcriptional regulator involved in developmental processes. this is major determinant crucial to palatogenesis.
4213	
4214	
4215	probable transcription factor. plays a critical role in the control of immune response.
4216	does not bind melatonin.
4217	transcriptional corepressor. may specifically inhibit gene expression when recruited to promoter regions by sequence specific dna-binding proteins such as bcl6 and mllt3. this repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.
4218	
4219	
4220	
4221	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
4222	
4223	high-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. may also function as an ecotropic retroviral leukemia receptor.
4224	required for protein transport from the endoplasmic reticulum to the golgi complex (by similarity).
4225	dorsalizing factor. key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing tgf-beta family bone morphogenetic proteins (bmps) and sequestering them in latent complexes.
4226	involved in the apoptotic response after nerve growth factor (ngf) binding in neuronal cells. binds p75ntr and antagonizes its association with trka, inhibits cell cycle progression, and facilitates p75ntr-mediated apoptosis. may act as a regulator of the function of dlx family members (by similarity).
4227	regulatory subunit part of the ikk-signalosome complex activation. also considered to be a mediator for tax activation of nf-kappa-b. could be implicated in nf-kappa-b-mediated protection from cytokine toxicity.
4228	inhibitory effect on stress fiber organization. may down-regulate rho-like gtpase in hematopoietic cells.
4229	required for the uptake of creatine in muscles and brain.
4230	putative adhesion molecule that mediates sialic-acid dependent binding to cells. binds equally to alpha2,3-linked and alpha2,6-linked sialic acid. the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
4231	
4232	
4233	
4234	
4235	
4236	binds rna.
4237	inhibits the transcription of ribosomal rna. may inhibits the specific dna binding of ubf1.
4238	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
4239	
4240	
4241	catalyzes two distinct but analogous reactions: the epimerization of udp-glucose to udp-galactose and the epimerization of udp-n-acetylglucosamine to udp-n- acetylgalactosamine.
4242	cytochalasin b-sensitive carrier. seems to function primarily as a fructose transporter.
4243	
4244	this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of sodium and potassium ions across the plasma membrane. this action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
4245	probably involved in the organization of the actin cytoskeleton. may act downstream of cdc42 to induce actin filament assembly leading to cell shape changes. induces pseudopodia formation in fibroblasts in a cdc42-dependent manner.
4246	
4247	
4248	may be involved in transcriptional regulation.
4249	
4250	
4251	
4252	isoform f play a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.
4253	
4254	the numerous interruptions in the triple helix may make this molecule either elastic or flexible.
4255	
4256	required for left-right (l-r) asymmetry determination of organ systems in mammals. may play a role in endometrial bleeding.
4257	igf-1 leads to the activation of akt3, which may play a role in regulating cell survival. capable of phosphorylating several known proteins. truncated isoform 2/pkb gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
4258	protein 4.1 is a major structural element of the erythrocyte membrane skeleton. it plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. recruits dlg1 to membranes.
4259	plays a role in transcriptional coactivation.
4260	
4261	
4262	
4263	involved in muscle differentiation (myogenic factor). induces fibroblasts to differentiate into myoblasts. probable sequence specific dna-binding protein.
4264	converts udp and glcnac-1-p into udp-glcnac, and udp and galnac-1-p into udp-galnac. isoform agx1 has 2 to 3 times higher activity towards galnac-1-p, while isoform agx2 has 8 times more activity towards glcnac-1-p.
4265	high-affinity transporter for the intake of thiamine.
4266	orphan receptor.
4267	could be involved in the induction of mineralization of extracellular matrix.
4268	
4269	may act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway.
4270	may act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway.
4271	
4272	
4273	
4274	
4275	
4276	this proteoglycan is a major component of extracellular matrix of cartilagenous tissues. a major function of this protein is to resist compression in cartilage. it binds avidly to hyaluronic acid via an n-terminal globular region.
4277	tyrosine kinase that plays an essential role for the selection and maturation of developing t-cell in the thymus and in mature t-cell function. is constitutively associated with the cytoplasmic portions of the cd4 and cd8 surface receptors and plays a key role in t-cell antigen receptor(tcr)-linked signal transduction pathways. association of the tcr with a peptide antigen-bound mhc complex facilitates the interaction of cd4 and cd8 with mhc class ii and class i molecules, respectively, and thereby recruits the associated lck to the vicinity of the tcr/cd3 complex. lck then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (itams) in the cytoplasmic tails of the tcrgamma chains and cd3 subunits, initiating the tcr/cd3 signaling pathway. in addition, contributes to signaling by other receptor molecules. associates directly with the cytoplasmic tail of cd2, and upon engagement of the cd2 molecule, lck undergoes hyperphosphorylation and activation. also plays a role in the il2 receptor-linked signaling pathway that controls t-cell proliferative response. binding of il2 to its receptor results in increased activity of lck. is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-tcr and mature alpha beta tcr.
4278	l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists. this receptor binds kainate > quisqualate > domoate > l-glutamate >> ampa >> nmda = 1s,3r-acpd.
4279	molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin. plays a role in the assembly of the von hippel- lindau ubiquitination complex.
4280	
4281	
4282	
4283	
4284	subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-golgi network (tgn) to the endosomal-lysosomal system.
4285	essential for normal development of the vasculature. may represent a naturally occurring ligand of the immunophilins fkbp59 and fkbp12. may function as an membrane anchoring protein. isoform 1 may stimulate the p70s6k pathway. isoform 2 may inhibit cell proliferation and increase il2 production.
4286	required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier. functions as a homophilic cell-adhesion molecule. may play a role in early neuronal differentiation and axon outgrowth.
4287	inactivates paf by removing the acetyl group at the sn-2 position. this is a catalytic subunit. plays an important role during the development of brain.
4288	component of the peroxisomal translocation machinery with pex13 and pex17. interacts with both the pts1 and pts2 receptors. binds directly to pex17.
4289	acts as a negative regulator of receptor-dependent signaling pathways. specifically inhibits transactivation of the nuclear receptor with whom it interacts.
4290	required for normal golgi morphology and function.
4291	
4292	the gamma subunit has a critical role in allowing the ige fc receptor to reach the cell surface.
4293	binds to pre-mrna. has high affinity for scaffold- attached region (sar) dna. bind to double- and single-stranded dna and rna.
4294	
4295	
4296	
4297	methylates cpg residues. preferentially methylates hemimethylated dna. it is responsible for maintaining methylation patterns established in development. mediates transcriptional repression by direct binding to hdac2.
4298	
4299	this receptor binds polymeric iga and igm at the basolateral surface of epithelial cells. the complex is then transported across the cell to be secreted at the apical surface. during this process a cleavage occurs that separate the extracellular (known as the secretory component) from the transmembrane segment (by similarity).
4300	
4301	implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2a, regulation of mrna trafficking and stability in association with elavl1, and inhibition of acetyltransferases as part of the inhat (inhibitor of histone acetyltransferases) complex (by similarity).
4302	may play a role in photoresponse. retinoids, and most likely retinal, are the natural substrates for transport by abcr in rod outer segments. may act in the visual cycle to flip pe-all- trans-retinal adducts from the lumenal to the cytosolic face of the disk membrane, move free all-trans-retinal from the lipid phase of the disk membrane to a juxtamembrane location, or possibly reorient all-trans-retinal in the bilayer.
4303	receptor for extracellular adenine nucleotides such as atp and adp. in platelets binding to adp leads to mobilization of intracellular calcium ions via activation of phospholipase c, a change in platelet shape, and probably to platelet aggregation.
4304	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. ladsin exerts cell- scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.
4305	
4306	may modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release by potentiating the interaction of synaptotagmins with the snares and the plasma- membrane-associated protein snap25. its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. may also have a role in the mechanisms of snare-mediated membrane fusion in non-neuronal cells (by similarity).
4307	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
4308	
4309	
4310	
4311	cd2 interacts with lymphocyte function-associated antigen (lfa-3) and cd48/bcm1 to mediate adhesion between t-cells and other cell types. cd2 is implicated in the triggering of t- cells, the cytoplasmic domain is implicated in the signaling function.
4312	
4313	forms a ternary complex with the serum response factor (srf). requires dna-bound srf for ternary complex formation and makes extensive dna contacts to the 5@#$%&side of srf, but does not bind dna autonomously.
4314	probable helicase involved in mitochondrial functions. required for rapid turnover of mrnas containing a premature translational termination codon.
4315	receptor for obesity factor (leptin). on ligand binding, mediates signaling through jak2/stat3. involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. may play a role in reproduction. can also mediate the erk/fos signaling pathway (by similarity).
4316	assembly of polyisoprenoid side chains. the polyprenyl synthetase of coenzyme q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species.
4317	acts as a transcriptional repressor. binds to e-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes (by similarity).
4318	protein transport. probably involved in vesicular traffic (by similarity).
4319	
4320	
4321	vimentins are class-iii intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.
4322	vimentins are class-iii intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.
4323	
4324	exhibits a high coumarin 7-hydroxylase activity. can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. competent in the metabolic activation of aflatoxin b1. constitutes the major nicotine c-oxidase.
4325	
4326	promotes guanine-nucleotide exchange on arf5. promotes the activation of arf5 through replacement of gdp with gtp (by similarity).
4327	
4328	transfers 1,4-n-acetylgalactosamine (galnac) from udp- galnac to the nonreducing end of glucuronic acid (glcua). required for addition of the first galnac to the core tetrasaccharide linker and for elongation of chondroitin chains.
4329	may participate in diverse steps of neurogenesis. binds calcium.
4330	
4331	
4332	
4333	
4334	
4335	thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. during neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (by similarity). slit1 and slit2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.
4336	
4337	transcriptional repressor. mxi1 binds with max to form a sequence-specific dna-binding protein complex which recognizes the core sequence 5@#$%&-cac[ga]tg-3@#$%&. mxi1 thus antagonizes myc transcriptional activity by competing for max.
4338	
4339	attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to na-k atpase, to the lymphocyte membrane protein gp85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. in skeletal muscle, isoform mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
4340	tfiif is a general transcription initiation factor that binds to rna polymerase ii and helps to recruit it to the initiation complex in collaboration with tfiib. it promotes transcription elongation.
4341	
4342	regulates the gdp/gtp exchange reaction of most rab proteins by inhibiting the dissociation of gdp from them, and the subsequent binding of gtp to them.
4343	
4344	type i collagen is a member of group i collagen (fibrillar forming collagen).
4345	rna-binding protein. possesses nucleolytic activity against cytotoxic lymphocyte target cells. may be involved in apoptosis.
4346	may be involved in mitogenic function of fgf1.
4347	
4348	
4349	
4350	
4351	may be involved in melanosomal transport and docking. involved in the proper sorting of tyrp1.
4352	binds to the dendritic targeting element and may play a role in mrna trafficking (by similarity). part of a ternary complex that binds to the downstream control sequence (dcs) of the pre-mrna. mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. may interact with single- stranded dna from the far-upstream element (fuse). may activate gene expression. also involved in degradation of inherently unstable mrnas that contain au-rich elements (ares) in their 3@#$%& untranslated regions, possibly by recruiting degradation machinery to are-containing mrnas.
4353	has n-acetylated-alpha-linked-acidic dipeptidase (naaladase) activity. also exhibits a dipeptidyl-peptidase iv type activity. inactivate the peptide neurotransmitter n- acetylaspartylglutamate.
4354	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
4355	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
4356	may play an essential role at the early stage of chromosomal dna replication by coupling the polymerase alpha/primase complex to the cellular replication machinery (by similarity).
4357	
4358	
4359	
4360	pyruvate carboxylase catalyzes a 2-step reaction, involving the atp-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
4361	
4362	
4363	can degrade fibronectin, laminin, gelatins of type i, iii, iv, and v; collagens iii, iv, x, and ix, and cartilage proteoglycans. activates procollagenase.
4364	
4365	
4366	
4367	may be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium atpase.
4368	transcription factor involved in skull and limb development.
4369	
4370	pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
4371	
4372	
4373	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis (by similarity).
4374	
4375	
4376	
4377	
4378	
4379	binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
4380	receptor for gastrin and cholecystokinin. the ckk-b receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. this receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system.
4381	
4382	
4383	
4384	
4385	
4386	
4387	plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. could be an adhesion molecule active in neural crest cells during embryonic development. acts as surface receptor that triggers tyrosine phosphorylation of fyn and ptk2, and a transient increase in the intracellular calcium concentration.
4388	
4389	prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (er). binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (srp), which normally targets nascent secretory peptides to the er. also reduces the inherent affinity of ribosomes for protein translocation sites in the er membrane (m sites). may act as a specific coactivator for jun, binding to dna and stabilizing the interaction of jun homodimers with target gene promoters.
4390	protein transport. probably involved in vesicular traffic (by similarity).
4391	forms calcium-sensitive chloride channels. may conduct other physiologically significant anions such as bicarbonate (by similarity).
4392	
4393	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
4394	involved in directing the movement of organelles along actin filaments (potential).
4395	single-stranded dna binding protein that interacts with the region upstream of the c-myc gene. binds specifically to the dna sequence motif 5@#$%&-[at]ct[at][at]t-3@#$%&. probably has a role in dna replication.
4396	intercellular signal essential for a variety of patterning events during development. may function as a spermatocyte survival factor in the testes. essential for testes development.
4397	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity).
4398	
4399	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
4400	required only in the female germ line. it is important for oocyte formation and in the specification of the posterior structures of the embryo.
4401	required for protein transport from the er to the golgi complex.
4402	may be involved in regulation of synaptic vesicle endocytosis. may act as a tumor suppressor and inhibits malignant cell transformation.
4403	may be involved in fusion of er-derived transport vesicles with the golgi complex.
4404	
4405	may play a role in junctional plaques.
4406	
4407	plays a key role in hematopoiesis. this ptpase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. the sh2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates.
4408	glandular kallikreins cleave met-lys and arg-ser bonds in kininogen to release lys-bradykinin.
4409	
4410	
4411	
4412	
4413	displays temperature-dependent chaperone activity. according to ref.3 it acts as a mn(2+)-dependent serine-threonine- specific protein kinase. we are not convinced that this is its true role.
4414	nuclear hormone receptor. vdr mediates the action of vitamin d3 by controlling the expression of hormone sensitive genes.
4415	
4416	thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. in vitro it binds mhc, f-actin and native thin filaments, and modifies the activity of actin-activated myosin atpase. it may modulate muscle contraction or may play a more structural role.
4417	
4418	
4419	specifically removes c-terminal basic residues (arg or lys) from peptides and proteins. it is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.
4420	required for the binding of mrna to ribosomes. functions in close association with eif4-f and eif4-a. binds near the 5@#$%&- terminal cap of mrna in presence of eif-4f and atp. promotes the atpase activity and the atp-dependent rna unwinding activity of both eif4-a and eif4-f.
4421	probable e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. non essential.
4422	binds to gtp-bound form of rho and to profilin. acts in a rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. it is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics (by similarity).
4423	
4424	transcriptional repressor. acts on the c-type natriuretic peptide (cnp) promoter.
4425	
4426	
4427	
4428	involved in connections of major cytoskeletal structures to the plasma membrane.
4429	
4430	may play a role in ubiquitination and subsequent proteosomal degradation of target proteins.
4431	
4432	component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity.
4433	
4434	presents carbohydrate ligands to selectins. also implicated in tumor cell metastasis.
4435	molecular chaperone. has atpase activity (by similarity).
4436	molecular chaperone. has atpase activity (by similarity).
4437	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
4438	although its physiological function is unclear, it can inhibit neutrophil cathepsin g and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
4439	binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to tram (translocating chain-associating membrane protein).
4440	
4441	
4442	binds pre-mrna and nucleates the assembly of 40s hnrnp particles. single hnrpc tetramers bind 230-240 nucleotides. trimers of hnrpc tetramers bind 700 nucleotides. may play a role in the early steps of spliceosome assembly and pre-mrna splicing. interacts with poly-u tracts in the 3@#$%& or 5@#$%& untranslated regions of mrna and modulates the stability and the level of translation of bound mrna molecules.
4443	cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. possesses a wide variety of biological activities. exhibits antibacterial activity.
4444	involved in the base excision repair (ber) pathway, by catalyzing the poly(adp-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in dna metabolism. this modification follows dna damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of dna strand breaks.
4445	involved in neurogenesis.
4446	
4447	cell adhesion glycoprotein which is widely distributed in basement membranes. binds to collagens i and iv, to perlecan and to laminin 1. does not bind fibulins. it probably has a role in cell-extracellular matrix interactions.
4448	participates in dna repair and in chromosomal dna replication.
4449	
4450	
4451	its physiological role is not yet clear.
4452	
4453	
4454	receptor for extracellular atp > utp and adp. the activity of this receptor is mediated by g proteins which activate a phosphatidylinositol-calcium second messenger system. may be the cardiac p2y receptor involved in the regulation of cardiac muscle contraction through modulation of l-type calcium currents. is a receptor for leukotriene b4, a potent chemoattractant involved in inflammation and immune response.
4455	receptor for extracellular atp > utp and adp. the activity of this receptor is mediated by g proteins which activate a phosphatidylinositol-calcium second messenger system. may be the cardiac p2y receptor involved in the regulation of cardiac muscle contraction through modulation of l-type calcium currents. is a receptor for leukotriene b4, a potent chemoattractant involved in inflammation and immune response.
4456	
4457	
4458	required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors. may bind a rab gtpase such as vps21.
4459	
4460	
4461	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
4462	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
4463	
4464	
4465	
4466	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
4467	reversible hydration of carbon dioxide.
4468	functions as an e3-type small ubiquitin-like modifier (sumo) ligase, stabilizing the interaction between ube2i and the substrate, and as a sumo-tethering factor. plays a crucial role as a transcriptional coregulation in various cellular pathways, including the stat pathway, the p53 pathway and the steroid hormone signaling pathway. the effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
4469	functions as an e3-type small ubiquitin-like modifier (sumo) ligase, stabilizing the interaction between ube2i and the substrate, and as a sumo-tethering factor. plays a crucial role as a transcriptional coregulation in various cellular pathways, including the stat pathway, the p53 pathway and the steroid hormone signaling pathway. the effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
4470	carries 11-cis-retinol and 11-cis-retinaldehyde as endogenous ligands and may be a functional component of the visual cycle.
4471	
4472	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
4473	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
4474	required for protein transport from the er to the golgi complex.
4475	
4476	
4477	
4478	
4479	
4480	
4481	
4482	critical component of the membrane-bound oxidase of phagocytes that generates superoxide. associates with nox3 to form a functional nadph oxidase constitutively generating superoxide.
4483	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
4484	
4485	component of the transcription factor sl1/tifib complex involved in the assembly of the pic (preinitiation complex). recruits rna polymerase i to the rrna gene promoter via interaction with rrn3.
4486	
4487	
4488	may be involved in transcriptional regulation.
4489	required for protein transport from the er to the golgi complex.
4490	able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-coa species.
4491	inter-alpha-trypsin inhibitor, present in plasma and urine, inhibits trypsin, plasmin, and lysosomal granulocytic elastase (by similarity).
4492	
4493	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
4494	
4495	clathrin is the major protein of the polyhedral coat of coated pits and vesicles. two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-golgi network.
4496	putative odorant receptor.
4497	
4498	in addition to gelatin and collagens, it cleaves kiss1 at a gly-|-leu bond.
4499	
4500	
4501	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
4502	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
4503	suppresses tnf- and cd40-induced nfkb1 activity at the level of the ikk complex, by inhibiting nfkbia degradation induced by tnf. when associated with pycard, activates casp1, leading to the secretion of mature proinflammatory cytokine il1b. may be a component of the inflammasome, a protein complex which also includes pycard, card8 and casp1 and whose function would be the activation of proinflammatory caspases.
4504	acetyltransferase enzyme. acetylates histones, giving a specific tag for transcriptional activation. also acetylates non- histone proteins, like ncoa3 coactivator. mediates camp-gene regulation by binding specifically to phosphorylated creb protein. cbp, as coactivator, augments the activity of phosphorylated creb to activate transcription of camp-responsive genes.
4505	
4506	
4507	
4508	catalyzes three sequential methylation of phosphatidylethanolamine (pe) by adomet, thus producing phosphatidylcholine (pc).
4509	interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. the interaction is mediated by the sh2 domain. also binds to erbb2.
4510	
4511	binds to the 5@#$%&-aacaat-3@#$%& sequence.
4512	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (by similarity).
4513	the 26s protease is involved in the atp-dependent degradation of ubiquitinated proteins. the regulatory (or atpase) complex confers atp dependency and substrate specificity to the 26s complex.
4514	senses unfolded proteins in the lumen of the endoplasmic reticulum via its n-terminal domain which leads to enzyme auto- activation. the active endoribonuclease domain splices xbp1 mrna to generate a new c-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
4515	involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion (by similarity).
4516	could be involved in calcium-dependent cell adhesion or intercellular interactions.
4517	
4518	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
4519	
4520	
4521	proteolytically removes the c-terminal three residues of farnesylated and geranylated proteins. seems to be able to process k-ras, n-ras, h-ras, rap1b and g-gamma-1.
4522	sequence-selective dna-binding protein. could play an important role in gene regulation.
4523	
4524	
4525	probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. its precise role is however unclear, since it does not bind to very low density lipoprotein (vldl) or to lrpap1 in vitro.
4526	anti-proliferative protein that interacts with the erbb- 2 receptor tyrosine kinase. may physically and/or functionally interact with protein-tyrosine kinase receptors.
4527	may play a role in determining the production of hemoglobin s. may act as a repressor.
4528	
4529	this protein is one of the chains of the nonenzymatic membrane component (f0) of mitochondrial atpase.
4530	may be involved in transcriptional regulation.
4531	involved in nucleolar processing of pre-18s ribosomal rna (by similarity).
4532	the physiological role for the icosapeptide has not yet been elucidated.
4533	metabolizes sarcosine, l-pipecolic acid and l-proline.
4534	plays a major role in tight junction-specific obliteration of the intercellular space (by similarity).
4535	
4536	serine/threonine kinase that may play a role in the response to environmental stress. appears to act upstream of the jun n-terminal pathway. may play a role in the development of the brain (by similarity).
4537	serine/threonine kinase that may play a role in the response to environmental stress. appears to act upstream of the jun n-terminal pathway. may play a role in the development of the brain (by similarity).
4538	
4539	aminopeptidase with broad substrate specificity to several peptides. involved in proteolytic events essential for cell growth and viability. may act as regulator of neuropeptide activity (by similarity).
4540	involved in the targeting and/or fusion of transport vesicles to their target membrane.
4541	inhibits primary neurogenesis. may be required to divert neurons along a specific differentiation pathway. plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (by similarity).
4542	involved in transcriptional activation and repression of select genes by chromatin remodelling (alteration of dna- nucleosome topology). required for the coactivation of estrogen responsive promoters by swi/snf complexes and the src/p160 family of histone acetyltransferases (hats). also specifically interacts with the corest corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.
4543	
4544	
4545	
4546	catalyzes the deacetylation of n-acetylaspartic acid (naa) to produce acetate and l-aspartate. naa occurs in high concentration in brain and its hydrolysis naa plays a significant part in the maintenance of intact white matter. in other tissues it act as a scavenger of naa from body fluids.
4547	involved in the transcriptional regulation of genes required for mesoderm differentiation. probably plays a role in limb pattern formation.
4548	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
4549	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
4550	promotes infectivity of neisseria gonorrhoeae in epithelial cells by phosphorylating mcp/cd46.
4551	collagen type iv is specific for basement membranes.
4552	
4553	part of the postsynaptic scaffold in neuronal cells.
4554	adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. preferentially binds to alpha2,3- linked sialic acid (by similarity).
4555	may be involved in transcriptional regulation.
4556	may be involved in transcriptional regulation.
4557	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
4558	may be involved in transcriptional regulation.
4559	acts as a receptor for urokinase plasminogen activator. plays a role in localizing and promoting plasmin formation. mediates the proteolysis-independent signal transduction activation effects of u-pa. it is subject to negative-feedback regulation by u-pa which cleaves it into an inactive form.
4560	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2). icam3 is also a ligand for integrin alpha-d/beta-2.
4561	
4562	may be involved in transcriptional regulation.
4563	
4564	plays a role in transcriptional coactivation.
4565	
4566	
4567	this receptor has essential roles in the regulation of ige production and in the differentiation of b-cells (it is a b- cell-specific antigen).
4568	
4569	
4570	
4571	endonuclease that specifically degrades the rna of rna- dna hybrids. participates in dna replication.
4572	may be a member of a yet unidentified signaling pathway and it may act as a tumor-suppressor.
4573	
4574	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
4575	during embryonic development, some isoforms are essential for proper neuronal differentiation and organization. required for cell polarity; maintenance of apicobasal polarity. plays a critical role at septate junctions in cellular growth control during larval development. the presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
4576	
4577	
4578	receptor for the chemotactic and inflammatory peptide anaphylatoxin c5a, c4a and c3a and their desarginated derivatives. couples weakly to gi-mediated signaling pathways.
4579	
4580	
4581	suppresses tnf- and cd40-induced nfkb1 activity at the level of the ikk complex, by inhibiting nfkbia degradation induced by tnf. when associated with pycard, activates casp1, leading to the secretion of mature proinflammatory cytokine il1b. may be a component of the inflammasome, a protein complex which also includes pycard, card8 and casp1 and whose function would be the activation of proinflammatory caspases.
4582	promotes the exchange of ras-bound gdp by gtp. this protein positively controls the level of cellular camp at start, the stage at which the yeast cell division cycle is triggered.
4583	serine/threonine kinase which acts as a positive regulator of apoptosis.
4584	
4585	
4586	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
4587	
4588	
4589	may be involved in the activation of cells of innate and acquired immunity.
4590	
4591	binds a vh promoter proximal site necessary for induced mu-heavy-chain transcription. binds the minor groove of a restricted atc sequence that is sufficient for nuclear matrix association. this sequence motif is present in matrix-associating regions (mars) proximal to the promoter and flanking e mu. activates e mu-driven transcription by binding these sites (by similarity).
4592	has strong antimicrobial activity against e.coli ml35p n.cinerea and weaker against s.epidermidis, s.aureus and group b streptococcus bacteria. active against the fungus c.albicans. no activity against p.aeruginosa.
4593	type i collagen is a member of group i collagen (fibrillar forming collagen).
4594	activates transcription from class ii mhc promoters. activation requires the activity of the mhc class ii transactivator (mhc2ta). may regulate other genes in the cell. rfx binds the x1 box of mhc-ii promoters. isoform rfx-b-delta5 is not involved in the positive regulation of mhc class ii genes.
4595	
4596	converts proline to delta-1-pyrroline-5-carboxylate.
4597	may be involved in transcriptional regulation.
4598	
4599	
4600	
4601	
4602	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
4603	recognizes and binds the palindromic sequence 5@#$%&- ttggcnnnnngccaa-3@#$%& present in viral and cellular promoters and in the origin of replication of adenovirus type 2. these proteins are individually capable of activating transcription and replication.
4604	part of a post-splicing multiprotein complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity (by similarity).
4605	
4606	may act at junctions between the membrane and the cytoskeleton.
4607	
4608	
4609	may play a role in testis development (by similarity).
4610	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
4611	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
4612	crystallins are the dominant structural components of the vertebrate eye lens.
4613	
4614	necessary for the splicing of pre-mrna. directly contacts the pre-mrna branch site adenosine for the first catalytic step of splicing. enters the spliceosome and associates with the pre-mrna branch site as part of the 17s u2 or, in the case of the minor spliceosome, as part of the 18s u11/u12 snrnp complex, and thus may facilitate the interaction of these snrnp with the branch sites of u2 and u12 respectively.
4615	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
4616	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
4617	plasma membrane-associated small gtpase which cycles between an active gtp-bound and inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.
4618	plays a role in autophagy (by similarity).
4619	crystallins are the dominant structural components of the vertebrate eye lens.
4620	may be involved in assembly and membrane stacking of the golgi cisternae, and in the process by which golgi stacks reform after mitotic breakdown. may regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane tgfa.
4621	in the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, nonnucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.
4622	calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic ca(2+) signaling.
4623	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
4624	
4625	dsp may be an important factor in dentinogenesis. dpp may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.
4626	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
4627	
4628	has growth cone collapse activity against retinal ganglion-cell axons (by similarity).
4629	
4630	possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
4631	
4632	
4633	sodium-phosphate symporter. active in early growth phase.
4634	
4635	
4636	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
4637	
4638	recognizes and binds the 7-methylguanosine-containing mrna cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mrnas secondary structures.
4639	acts specifically as a negative regulator of skeletal muscle growth.
4640	
4641	
4642	
4643	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
4644	
4645	
4646	
4647	
4648	may be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. has cell adhesive capacity.
4649	
4650	
4651	
4652	
4653	required for correct chromosome alignement during metaphase. part of the mis12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis.
4654	
4655	
4656	
4657	
4658	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (by similarity).
4659	
4660	may be involved in transcriptional regulation.
4661	potential tumor suppressor. acts as a kras-specific effector protein. may promote apoptosis and cell cycle arrest.
4662	
4663	affects the rate of fibrils formation. may have a primary role in collagen fibrillogenesis (by similarity).
4664	
4665	pre-mrna binding protein in vivo, binds avidly to poly(g) and poly(u) rna homopolymers in vitro. involved in splicing. acts as a receptor for carcinoembryonic antigen in kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of il-1 alpha, il-6, il-10 and tumor necrosis factor alpha cytokines.
4666	
4667	involved in the maturation of asn-linked oligosaccharides. progressively trim alpha-1,2-linked mannose residues from man(9)glcnac(2) to produce man(5)glcnac(2).
4668	transcription factor capable of interacting with purine rich repeats (ga repeats). necessary for the expression of the adenovirus e4 gene.
4669	
4670	inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin a. could play a role during central nervous system development.
4671	
4672	ligand for the t-cell-specific cell surface receptor icos. acts as a costimulatory signal for t-cell proliferation and cytokine secretion; induces also b-cell proliferation and differentiation into plasma cells. could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory t-cell function (by similarity).
4673	
4674	
4675	
4676	may be involved in transcriptional regulation.
4677	essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. the ternary complex containing ufd1l, vcp and nploc4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the er to the cytoplasm, where they are degraded by the proteasome. the nploc4-ufd1l-vcp complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. it may be involved in the development of some ectoderm-derived structures.
4678	
4679	catalyzes the covalent attachment of ubiquitin to other proteins. mediates the selective degradation of short-lived and abnormal proteins. functions in the e6/e6-ap-induced ubiquitination of p53/tp53.
4680	
4681	associates with the ig-mu chain to form a molecular complex that is expressed on the surface of pre-b-cells.
4682	cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. converts leukotriene c4 (ltc4) to leukotriene d4 (ltd4).
4683	
4684	growth regulator. inhibits the proliferation of a number of tumor cell lines. it regulates cytokine production, including il-6, g-csf and gm-csf from endothelial cells.
4685	
4686	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
4687	
4688	may regulate cell apoptosis and cell differentiation. binds beta-galactoside. binds cd45, cd3 and cd4. inhibits cd45 protein phosphatase activity and therefore the dephosphorylation of lyn kinase.
4689	furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the rx(k/r)r consensus motif.
4690	stimulates specifically the gtpase activity of ypt6.
4691	transcriptional activator that binds to the sterol regulatory element 1 (sre-1) (5@#$%&-atcaccccac-3@#$%&) found in the flanking region of the ldrl and hmg-coa synthase genes.
4692	
4693	
4694	
4695	
4696	
4697	
4698	the gpib-v-ix complex functions as the von willebrand factor receptor and mediates von willebrand factor-dependent platelet adhesion to blood vessels. the adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis (by similarity).
4699	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
4700	
4701	integrin alpha-v/beta-5 is a receptor for fibronectin. it recognizes the sequence r-g-d in its ligand.
4702	regulates intracellular concentrations of taurine and glutamate. negatively modulates slc1a1/eaac1 glutamate transport activity by decreasing its affinity for glutamate. may be involved in membrane traffic (by similarity).
4703	
4704	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity.
4705	
4706	
4707	
4708	
4709	
4710	
4711	
4712	
4713	
4714	
4715	
4716	troponin is the central regulatory protein of striated muscle contraction. tn consists of three components: tn-i which is the inhibitor of actomyosin atpase, tn-t which contains the binding site for tropomyosin and tn-c. the binding of calcium to tn-c abolishes the inhibitory action of tn on actin filaments.
4717	
4718	dimethylates a single guanine residue at position 26 of most trnas using s-adenosyl-l-methionine as donor of the methyl groups.
4719	the lactotransferrin peptidase s60 domain 1 functions as a serine protease that cuts arginine rich regions. this function contributes to the antimicrobial activity.
4720	
4721	
4722	serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. may be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. may protect neurons from cell damage by tissue-type plasminogen activator.
4723	involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
4724	
4725	receptor for members of the ephrin-b family. binds to ephrin-b1, -b2 and -b3. may be involved in cell-cell interactions in the nervous system.
4726	
4727	copper chaperone for cytochrome c oxidase (cox). binds two copper ions and deliver them to the cu(a) site of cox (by similarity).
4728	
4729	
4730	
4731	
4732	
4733	
4734	
4735	
4736	growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. binds and activates vegfr-2 (flk1) and vegfr-3 (flt4) receptors.
4737	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
4738	binds to wnt proteins and inhibits their activities. may be involved in mesoderm segmentation.
4739	
4740	serves to link two monomer units of either igm or iga. in the case of igm, the j chain-joined dimer is a nucleating unit for the igm pentamer, and in the case of iga it induces larger polymers. it also help to bind these immunoglobulins to secretory component.
4741	transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. retinyl esters are storage forms of vitamin a. lrat plays a critical role in vision. it provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.
4742	component of the inner kinetochore plate. required for normal kinetochore assembly.
4743	
4744	the product of this enzyme, tetrahydrobiopterin (bh-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
4745	
4746	plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. exerts it highest activity toward 3-hydroxybutyryl-coa.
4747	collagen type iv is specific for basement membranes.
4748	
4749	
4750	
4751	
4752	
4753	
4754	
4755	enhances steroid receptor-mediated transcriptional activation as well as activating basal transcription (by similarity).
4756	enhances steroid receptor-mediated transcriptional activation as well as activating basal transcription (by similarity).
4757	functions as a calcium permeable cation channel. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis.
4758	synthesizes cyclic adp-ribose, a second messenger for glucose-induced insulin secretion. also has cadpr hydrolase activity. also moonlights as a receptor in cells of the immune system.
4759	
4760	
4761	may play an important role in development and maintenance of anterior structures. isoform ptx2c is involved in left-right asymmetry the developing embryo (by similarity).
4762	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. may be involved in the remodeling of the actin cytoskeleton. binds actin with high affinity both in the absence and presence of atp and its mechanochemical activity is inhibited by calcium ions. also acts as a gtpase activating protein on rho.
4763	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
4764	acts as catalytic component of the ccr4-not core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mrna deadenylase involved in mrna turnover. ccr4 has 3@#$%&-5@#$%& rnase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single stranded dna. discovered because of its role in the control of adh2 gene expression. it is required for the expression of genes involved in nonfermentative growth and it mediates or is required for the action of the spt6 and spt10 genes.
4765	catalyzes the addition of n-acetylglucosamine in beta 1- 6 linkage to the alpha-linked mannose of biantennary n-linked oligosaccharides. it is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.
4766	
4767	low concentration of a soluble form of interleukin-6 receptor acts as an agonist of il6 activity.
4768	
4769	satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide y and regulated by leptin in the hypothalamus. it promotes neuronal development and survival in vitro.
4770	may function actively to stimulate axon fasciculation. induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. this signaling event requires the activity of the fyn tyrosine kinase.
4771	
4772	
4773	
4774	
4775	
4776	
4777	catalyzes the covalent attachment of ubiquitin to other proteins. required for postreplication repair of uv-damaged dna. may be involved in neurite outgrowth.
4778	
4779	
4780	binds to wasl/n-wasp and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (by similarity). may be involved in pre-mrna splicing.
4781	neutral amino acid/proton symporter. has a ph-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. besides small apolar l-amino acids, it also recognize their d-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (by similarity).
4782	factor xii is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. prekallikrein is cleaved by factor xii to form kallikrein, which then cleaves factor xii first to alpha-factor xiia and then to beta-factor xiia. alpha- factor xiia activates factor xi to factor xia.
4783	neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
4784	tubulin-folding protein; involved in the early step of the tubulin folding pathway.
4785	
4786	
4787	
4788	
4789	
4790	probably important in the regulation of neuronal excitability. associates with kcnq3 to form a potassium channel which contributes to m-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. may contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of m-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. insensitive to tetraethylammonium, but inhibited by barium, linopirdine and xe991. activated by niflumic acid and the anticonvulsant retigabine. muscarine suppresses kcnq5 current in xenopus oocytes in which cloned kcnq5 channels were coexpressed with m(1) muscarinic receptors.
4791	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
4792	could be involved in cell-cell interactions.
4793	induces stromal cells to produce proinflammatory and hematopoietic cytokines (by similarity).
4794	acts preferentially on the c-jun n-terminal kinase (jnk) and p38 mapks. plays an important role in the heavy metal stress response by negatively regulating the kgb-1 (jnk-like) and the pmk-1 (p38-type) mapk signaling pathways.
4795	acts as a ligand for notch receptors. blocks the differentiation of progenitor cells into the b-cell lineage while promoting the emergence of a population of cells with the characteristics of a t-cell/nk-cell precursor.
4796	
4797	adapter protein that links fgr and ngf receptors to downstream signaling pathways. involved in the activation of map kinases. down-regulates erk2 signaling by interfering with the phosphorylation and nuclear translocation of erk2.
4798	binds to actin and affects the structure of the cytoskeleton. at high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. by binding to pip2, it inhibits the formation of ip3 and dg.
4799	
4800	
4801	
4802	strong transcriptional activator. associated with meiosis in both male and female gametogenesis. may have different functions in somatic cells.
4803	
4804	
4805	helicase; has atpase activity.
4806	
4807	
4808	
4809	
4810	involved in transport of proteins into the mitochondrion.
4811	
4812	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
4813	
4814	
4815	participates in the folding of proteins containing disulfide bonds (by similarity).
4816	has a role in pre-mrna splicing. phosphorylates sf2/asf.
4817	downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small gtpases to the actin cytoskeleton.
4818	important for the overall degradation of proteins in lysosomes. essential for adult male and female fertility. may play a role in digestion.
4819	
4820	
4821	
4822	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
4823	
4824	receptor for members of the ephrin-b family. binds to ephrin-b2. may have a role in events mediating differentiation and development.
4825	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
4826	
4827	
4828	could be involved in the unfolded protein response (upr) pathway. could enhance presenilin-mediated beta-amyloid protein 40 generation.
4829	organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. probably involved in the assembly of actin filament bundles present in microspikes, membrane ruffles, and stress fibers.
4830	organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. probably involved in the assembly of actin filament bundles present in microspikes, membrane ruffles, and stress fibers.
4831	type i collagen is a member of group i collagen (fibrillar forming collagen).
4832	
4833	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
4834	
4835	the mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, zp1, zp2, zp3, and zp4. zp3 is essential for sperm binding and zona matrix formation.
4836	the mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, zp1, zp2, zp3, and zp4. zp3 is essential for sperm binding and zona matrix formation.
4837	catalyzes the addition of n-acetylglucosamine in beta 1- 6 linkage to the alpha-linked mannose of biantennary n-linked oligosaccharides. it is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.
4838	catalyzes the addition of n-acetylglucosamine in beta 1- 6 linkage to the alpha-linked mannose of biantennary n-linked oligosaccharides. it is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.
4839	required for 60s ribosomal subunit synthesis. probably involved in the processing of 27s rrna to produce mature 25s rrna.
4840	
4841	ca(2+)-regulated actin-binding protein.
4842	beta-oxidation of fatty acids. the highest activity concerns the c6 to c10 chain length substrate. converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- coa, to its corresponding carnitine ester.
4843	involved in vesicular protein trafficking.
4844	drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively. binds f-actin.
4845	
4846	
4847	
4848	probable rho/rac effector that binds to the gtp-bound forms of rho and rac1. it probably binds p21 with a tighter specificity in vivo. dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. plays an important role in the regulation of cytokinesis and the development of the central nervous system.
4849	forms hydroxylysine residues in -xaa-lys-gly- sequences in collagens. these hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen crosslinks.
4850	
4851	responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain.
4852	transcriptional repressor involved in the regulation of cell growth. inhibits cell growth. binds to the consensus sequence 5@#$%&-ggtgtg-3@#$%&.
4853	
4854	plays a role in papillomavirus genes transcription.
4855	may be involved in transcriptional regulation.
4856	catalyzes a base-exchange reaction in which the polar head group of phosphatidylcholine is replaced by l-serine (by similarity).
4857	
4858	
4859	
4860	reversible hydration of carbon dioxide.
4861	has steroid 11-beta-hydroxylase activity. in addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome p450 xib.
4862	acts as a transcriptional repressor.
4863	protein kinase that plays an important role in cellular stress response. activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic foxo3a. phosphorylates nedd4l, which leads to its inactivation and to the subsequent activation of various channels and transporters such as enac, kv1.3, or eaat1.
4864	seems to function as an adapter protein. in adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. seems to couple transcription factor sox4 to the il-5 receptor (il5ra). may also play a role in vesicular trafficking. seems to be required for the targeting of tgfa to the cell surface in the early secretory pathway.
4865	beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of g proteins. beta-3 is involved in the regulation of lipolysis and thermogenesis.
4866	
4867	may act as a chaperone.
4868	exhibits antimicrobial activity against gram-positive bacteria s.aureus and s.pyogenes, gram-negative bacteria p.aeruginosa and e.coli and the yeast c.albicans. kills multiresistant s.aureus and vancomycin-resistent e.faecium. no significant hemolytic activity was observed.
4869	receptor for the cytotoxic ligand tnfsf10/trail. the adapter molecule fadd recruits caspase-8 to the activated receptor. the resulting death-inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. promotes the activation of nf- kappa-b.
4870	transcriptional repressor. involved in the generation and migration of neural crest cells.
4871	
4872	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
4873	
4874	cleaves collagens of types i, ii, and iii at one site in the helical domain. also cleaves collagens of types vii and x.
4875	component of the cleavage and polyadenylation specificity factor (cpsf) complex that plays a key role in pre- mrna 3@#$%&-end formation, recognizing the aauaaa signal sequence and interacting with poly(a) polymerase and other factors to bring about cleavage and poly(a) addition. this subunit is involved in the rna recognition step of the polyadenylation reaction.
4876	
4877	homophilic cell adhesion molecule that promotes axonal growth. may play a role in nerve regeneration and in the formation and function of other tissues. cell adhesion requires divalent cations.
4878	responsible for the biosynthesis of pyroglutamyl peptides. has a bias against acidic and tryptophan residues adjacent to the n-terminal glutaminyl residue and a lack of importance of chain length after the second residue.
4879	dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. probably plays a central role at and after the meiotic phase of spermatogenesis (by similarity).
4880	may act as a scaffold protein that may assemble active ikk-map3k14 complexes (ikka, ikkb and map3k14/nik).
4881	may play a role in germ line formation.
4882	may be involved in transcriptional regulation.
4883	facilitative glucose transporter; binds cytochalasin b with low affinity.
4884	cytokine that binds to tnfrsf8/cd30. induces proliferation of t-cells.
4885	
4886	may be required for testis development.
4887	adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. association to the receptor is also mediated by the interaction with tradd. mediates activation of nf-kappa-b and jnk and is involved in apoptosis. the traf1/traf2 complex recruits the apoptotic suppressors birc2 and birc3 to tnfrsf1b/tnfr2. seems to be involved in il-15 signaling.
4888	plays a role in synaptic vesicle recycling, in particular in clathrin-mediated vesicle endocytosis. exhibits lysophosphatidic acid acyltransferase activity (lpaat).
4889	implicated in vesicle trafficking to lysosomes. could be involved in processes related to cell division (by similarity).
4890	
4891	catalyzes the covalent attachment of ubiquitin to other proteins. required for postreplication repair of uv-damaged dna.
4892	
4893	transport of small lipophilic substances (potential).
4894	cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.
4895	member of the cyclin-dependent kinase pair (cdk9/cyclin- t) complex, also called positive transcription elongation factor b (p-tefb), which facilitates the transition from abortive to production elongation by phosphorylating the ctd (c-terminal domain) of the large subunit of rna polymerase ii (rnap ii), supt5h and rdbp. the cdk9/cyclin-k complex has also a kinase activity toward ctd of rnap ii and can substitute for p-tefb in vitro.
4896	
4897	appears to function in modulating the activity of the immune system during the acute-phase reaction.
4898	catalyzes fat and vitamin absorption. acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.
4899	required for vesicle docking or fusion during acrosome biogenesis (by similarity). may play a role in rna trafficking or localization. in case of infection by hiv-1, acts as a cofactor for viral rev and promotes movement of rev-responsive element- containing rnas from the nuclear periphery to the cytoplasm. this step is essential for hiv-1 replication.
4900	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. this receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system.
4901	
4902	interconversion of serine and glycine.
4903	putative receptor for purines coupled to g-proteins (by similarity).
4904	
4905	protein kinase acting as a corepressor of several transcription factors, including smad1 and pou4f1/brn3a and probably nk homeodomain transcription factors. inhibits cell growth and promotes apoptosis. involved in transcriptional activation of tp53 and tp73. phosphorylation of tp53 may be mediated by a tp53-hipk2-axin1 complex. in response to tgfb, cooperates with daxx to activate jnk. phosphorylates the antiapoptotic factor ctbp1 and promotes its proteasomal degradation. in the wnt/beta-catenin signaling pathway acts as an intermediate kinase between tak1 and nlk to promote the proteasomal degradation of c-myb (by similarity).
4906	calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis (by similarity).
4907	
4908	
4909	
4910	receptor for members of the ephrin-a family. binds to ephrin-a2, -a3, -a4 and -a5. could play a role in lymphoid function.
4911	
4912	thought to form a receptor-activated non-selective calcium permeant cation channel. probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or g-protein coupled receptors. may also be activated by intracellular calcium store depletion.
4913	calcium-dependent mitochondrial aspartate and glutamate carrier. may have a function in the urea cycle.
4914	
4915	may play a role in junctional plaques.
4916	
4917	
4918	the intermediate chains seem to help dynein bind to dynactin 150 kda component.
4919	
4920	collagen type iv is specific for basement membranes. vital for embryonic development.
4921	
4922	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. this subunit has a chymotrypsin-like activity.
4923	type i collagen is a member of group i collagen (fibrillar forming collagen).
4924	
4925	
4926	catalyzes the cleavage of 5-oxo-l-proline to form l- glutamate coupled to the hydrolysis of atp to adp and inorganic phosphate.
4927	
4928	
4929	this is an intracellular thiol proteinase inhibitor.
4930	potential calcium-dependent cell-adhesion protein.
4931	converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. may function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes.
4932	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
4933	
4934	
4935	hydrolyzes an epoxide moiety of lta(4) to form ltb(4). the enzyme also has some peptidase activity (by similarity).
4936	may have a role in immune function. probably involved in the processing of antigenic peptides during mhc class ii-mediated antigen presentation. may play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
4937	part of the ap-3 complex, an adaptor-related complex which is not clathrin-associated. the complex is associated with the golgi region as well as more peripheral structures. it facilitates the budding of vesicles from the golgi membrane and may be directly involved in trafficking to lysosomes.
4938	
4939	
4940	
4941	
4942	
4943	pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. sp-b increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
4944	cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity.
4945	
4946	
4947	muscle contraction.
4948	side-chain deamidation of n-terminal asparagine residues to aspartate. required for the ubiquitin-dependent turnover of intracellular proteins that initiate with met-asn. these proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of n-acetyl methionine by acylaminoacid hydrolase (aah). conversion of the resulting n- terminal asparagine to aspartate by pnad renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the n-end rule. this enzyme does not act on substrates with internal or c-terminal asparagines and does not act on glutamine residues in any position.
4949	
4950	
4951	may catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl lewis x antigens.
4952	pore-forming (alpha) subunit of voltage-gated potassium channel. elicits a slowly activating, rectifying current (by similarity). channel properties may be modulated by camp and subunit assembly.
4953	
4954	transcription factor that can both stimulate and repress transcription. binds to the consensus dna sequence 5@#$%&-a/gcaggtg- 3@#$%&. regulates cell motility and adhesion during tracheal morphogenesis by stimulating transcription of the de-cadherin gene shg at branch tips, thereby promoting tracheal tube fusion. maintains diploidy in imaginal cells by inhibiting the transcription of genes required for endoreplication. required for development of the genital disk and acts as an intrinsic determinant of wing cell fate. the somatic protein is required for maintenance of male germ cells. acts with other members of the snail protein family to control embryonic central nervous system development.
4955	may be involved in transcriptional regulation.
4956	may be involved in transcriptional regulation.
4957	
4958	dual specificity protein phosphatase. may be involved in the control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules (polyglucosans).
4959	
4960	
4961	
4962	
4963	chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. inhibits proliferation of myeloid progenitors in colony formation assays. may be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. c-terminal processed forms have been shown to be equally chemotactically active for leukocytes. possesses antibacterial activity e.coli atcc 25922 and s.aureus atcc 29213.
4964	
4965	
4966	chaperone. isoform 2 may function as an endogenous inhibitory regulator of hsc70 by competing the cochaperones.
4967	
4968	
4969	necessary for cellular interactions with laminin and the extracellular matrix.
4970	
4971	
4972	
4973	sequence-specific rna-binding protein that regulates translation and mrna stability by binding the 3@#$%& untranslated regions (utrs) of mrna targets. may be required to support proliferation and self-renewal of stem cells (by similarity).
4974	
4975	involved in cytokinesis (potential).
4976	component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. three proteases; ndl, gd and snk process easter to create active easter. active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the tl receptor in the ventral region of the embryo. promotes heterophilic cellular adhesion. spz c-106 in the hemolymph controls expression of the antifungal peptide drosomycin (drs) by acting as a ligand of tl and inducing an intracellular signaling pathway.
4977	may be involved in the physiological processes of brain function. has no dipeptidyl aminopeptidase activity. may modulate the cell surface expression and the activity of the potassium channel kcnd2 (by similarity).
4978	
4979	
4980	inhibits factor x (x(a)) directly and, in a xa-dependent way, inhibits viia/tissue factor activity, presumably by forming a quaternary xa/laci/viia/tf complex. it possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
4981	
4982	
4983	required for protein transport from the er to the golgi complex.
4984	
4985	
4986	catalyzes the conversion of delta8-sterols to their corresponding delta7-isomers.
4987	
4988	isoform c is proteolytically inactive.
4989	
4990	
4991	
4992	
4993	associated to surface igm-receptor; may be involved in signal transduction. may be involved in regulation of the catalytic activity of type 2a-related serine/threonine phosphatases.
4994	associated to surface igm-receptor; may be involved in signal transduction. may be involved in regulation of the catalytic activity of type 2a-related serine/threonine phosphatases.
4995	could be involved in the transport of heme from the mitochondria to the cytosol. plays a central role in the maturation of cytosolic iron-sulfur (fe/s) cluster-containing proteins.
4996	atypical histone h2a which may be associated with transcriptionally active chromatin, explaining why it is excluded form barr bodies. nucleosomes containing it are less rigid and organize only 118 base pair of dna instead of 146 in classical nucleosomes.
4997	
4998	
4999	
5000	cell adhesion molecule with an important role in the development of the nervous system. involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. binds to axonin on neurons.
5001	may function as a tissue-specific nuclear mrna export factor.
5002	
5003	
5004	functions in segment determination through interaction with genes of bithorax (bx-c) and antennapedia (ant-c) complexes. it can behave as an activator of bx-c. involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. shown to bind zinc (in vitro).
5005	plays an important role in the organization of the cytoskeleton. binds to and sequesters actin monomers (g actin) and therefore inhibits actin polymerization (by similarity).
5006	
5007	
5008	
5009	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
5010	
5011	required for pseudopod elongation in transformed cells.
5012	
5013	component of the anaphase promoting complex/cyclosome (apc/c), a cell cycle-regulated e3 ubiquitin ligase that controls progression through mitosis and the g1 phase of the cell cycle.
5014	
5015	
5016	
5017	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
5018	
5019	calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. the release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. binds 40 to 50 moles of calcium. also binds laminin.
5020	
5021	
5022	plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ets1-mediated transcription of erythroid-specific genes in myeloid cells (by similarity).
5023	
5024	export receptor for importin-alpha. mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. in the nucleus binds cooperatively to importin-alpha and to the gtpase ran in its active gtp-bound form. docking of this trimeric complex to the nuclear pore complex (npc) is mediated through binding to nucleoporins. upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of ran-gtp to ran-gdp (induced by ranbp1 and rangap1, respectively) cause release of the importin-alpha from the export receptor. cse1l/xpo2 then return to the nuclear compartment and mediate another round of transport. the directionality of nuclear export is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus.
5025	this protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
5026	
5027	
5028	
5029	
5030	immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. participates also in the recruitment of tyrosine kinase syk.
5031	
5032	
5033	
5034	motor for anterograde axonal transport of synaptic vesicle precursors (by similarity).
5035	
5036	
5037	
5038	involved in tethering the chromosomes to the spindle pole and in chromosome movement. microtubule-based anterograde translocator for membranous organelles. plus end-directed microtubule sliding activity in vitro (by similarity).
5039	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
5040	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
5041	adenosylhomocysteine is a competitive inhibitor of s- adenosyl-l-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
5042	
5043	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. may play an important role in retinal development.
5044	has peptide-independent atpase activity.
5045	
5046	
5047	modulates the activity of rho-like proteins and connects extracellular signals to cytoskeletal activities. acts as a gdp- dissociation stimulator protein that stimulates the gdp-gtp exchange activity of rho-like gtpases and activates them. activates rac1, cdc42, and to a lesser extent rhoa.
5048	receptor for interferons alpha and beta. binding to type i ifns triggers tyrosine phosphorylation of a number of proteins including jaks, tyk2, stat proteins and ifnr alpha- and beta- subunits themselves.
5049	inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium.
5050	shows activity against influenza virus and vsv, a rhabdovirus.
5051	probably not catalytically active as it has lost the active site residues. may function not directly as a dna methyltransferase but as a regulator of methylation at imprinted loci. it is required specifically for the establishment of genomic imprints but is dispensable for their propagation. it is essential for the de novo methylation of single-copy dna sequences (by similarity).
5052	
5053	collagen type iv is specific for basement membranes. vital for embryonic development.
5054	involved in cytokinesis (potential).
5055	may play a role in rna metabolism.
5056	catalyzes the initial step in the synthesis of dolichol- p-p-oligosaccharides.
5057	tautomerization of d-dopachrome with decarboxylation to give 5,6-dihydroxyindole (dhi).
5058	
5059	catalyzes the transfer of ptdins and phosphatidylcholine between membranes.
5060	carrier protein. binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. binds with high affinity to alpha-tocopherol. also binds with a weaker affinity to other tocopherols and to tocotrienols. may have a transcriptional activatory activity via its association with alpha-tocopherol. probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
5061	
5062	
5063	
5064	actively transports glucose into cells by na(+) cotransport with a na(+) to glucose coupling ratio of 2:1. efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
5065	
5066	in muscle, the calcium-binding protein parvalbumin is thought to be involved in muscle relaxation.
5067	
5068	may activate the map kinase signaling pathway.
5069	force generating protein of respiratory cilia. produces force towards the minus ends of microtubules. dynein has atpase activity (by similarity).
5070	
5071	
5072	probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. is not an essential protein. involved in substrate recognition in ubiquitin-dependent degradation.
5073	transcriptional repressor of genes that require a bhlh protein for their transcription. may act as a negative regulator of myogenesis by inhibiting the functions of myod1 and ash1 (by similarity).
5074	
5075	thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (caz) which regulates neurotransmitter release. seems to act together with bsn. may recruit liprin-alpha proteins to the caz.
5076	thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (caz) which regulates neurotransmitter release. seems to act together with bsn. may recruit liprin-alpha proteins to the caz.
5077	
5078	
5079	
5080	neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. seems to play role in formation or maintenance of synaptic junctions. in vitro, triggers the de novo formation of presynaptic structures. may be involved in specification of excitatory synapses.
5081	
5082	
5083	putative odorant receptor. could also be involved in taste perception.
5084	the elongation of primed dna templates by dna polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (pcna) and activator 1. the 37 kda subunit may be involved in the elongation of the multiprimed dna template.
5085	contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.
5086	transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. required for the differentiation of pancreatic islet alpha cells (by similarity). competes with pax4 in binding to a common element in the glucagon, insulin and somatostatin promoters (by similarity). isoform 5a appears to function as a molecular switch that specifies target genes.
5087	receptor for chemokines scyc1 and scyc2. subsequently transduces a signal by increasing the intracellular calcium ions level.
5088	
5089	
5090	
5091	
5092	
5093	catalyzes the adenylation by atp of the carboxyl- terminal glycine of this.
5094	
5095	
5096	involved in the biosynthesis of l2/hnk-1 carbohydrate epitope on glycoproteins. can also play a role in glycosaminoglycan biosynthesis. substrates include asialo- orosomucoid (asor), asialo-fetuin, and asialo-neural cell adhesion molecule. requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group (by similarity).
5097	
5098	
5099	calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. is not activated by phorbol esters or diaglycerol. may play a role in the secretory response to nutrients. involved in cell polarization processes and the formation of epithelial tight junctions.
5100	
5101	
5102	
5103	
5104	cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. chemotactic for activated t-cells. binds to cxcr3.
5105	interacts with c-terminus of pcna. 5@#$%& phosphate residue is required for binding of the n-terminal dna-binding domain to duplex dna, suggesting a role in recognition of non-primer template dna structures during replication and/or repair.
5106	
5107	
5108	
5109	probably involved in egf and insulin receptor signaling.
5110	catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate.
5111	
5112	
5113	
5114	presumably involved in the processing and regular turnover of intracellular proteins. catalyzes the removal of unsubstituted n-terminal amino acids from various peptides.
5115	
5116	may be involved in several stages of intracellular trafficking (by similarity).
5117	
5118	muscle contraction.
5119	
5120	glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens.
5121	probably plays an important role in spermatogenesis. binds calcium ions.
5122	
5123	
5124	
5125	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
5126	
5127	
5128	
5129	required for autophagy.
5130	
5131	catalyzes the first committed step in the biosynthesis of complex n-glycans. it controls conversion of high mannose to complex n-glycans; the final hydrolytic step in the n-glycan maturation pathway.
5132	catalyzes the posttranslational formation of 4- hydroxyproline in -xaa-pro-gly- sequences in collagens and other proteins.
5133	
5134	
5135	
5136	
5137	interacts with zinc finger protein a20/tnfaip3 and inhibits tnf-induced nf-kappa-b-dependent gene expression by interfering with an rip- or traf2-mediated transactivation signal (by similarity). increases cell surface cd4(t4) antigen expression. interacts with hiv-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. may regulate matrix nuclear localization, both nuclear import of pic (preintegration complex) and export of gag polyprotein and viral genomic rna during virion production.
5138	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
5139	binds single-stranded rna. has a high affinity for g- rich and u-rich regions of hnrna. also binds to apob mrna transcripts around the rna editing site.
5140	may be involved in several stages of intracellular trafficking (by similarity).
5141	
5142	may be the gtpase, regulating atp sulfurylase activity.
5143	the mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, zp1, zp2, zp3, and zp4. zp1 ensures the structural integrity of the zona pellucida.
5144	
5145	regulatory subunit of the calcium activated potassium kcnma1 (maxik) channel. modulates the calcium sensitivity and gating kinetics of kcnma1, thereby contributing to kcnma1 channel diversity. increases the apparent ca(2+)/voltage sensitivity of the kcnma1 channel. it also modifies kcnma1 channel kinetics and alters its pharmacological properties. it slows down the activation and the deactivation kinetics of the channel. acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to kcnma1. its presence is also a requirement for internal binding of the kcnma1 channel opener dehydrosoyasaponin i (dhs-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (e2). increases the binding activity of charybdotoxin (ctx) toxin to kcnma1 peptide blocker by increasing the ctx association rate and decreasing the dissociation rate.
5146	
5147	
5148	
5149	hydrolyzes fatty acids from s-acylated cysteine residues in proteins such as trimeric g alpha proteins or hras. also has low lysophospholipase activity.
5150	
5151	
5152	
5153	
5154	
5155	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
5156	
5157	
5158	
5159	component of a probable scf-like e3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteosomal degradation of target proteins. probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (by similarity).
5160	
5161	cleaves the glcnac-asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
5162	
5163	
5164	
5165	required for checkpoint mediated cell cycle arrest in response to dna damage within both the s phase and g2/m phases of the cell cycle. may serve as a scaffold for the recruitment of dna repair and signal transduction proteins to discrete foci of dna damage marked by ser-139 phosphorylation of histone h2afx. also required for downstream events subsequent to the recruitment of these proteins. these include phosphorylation and activation of the atm, chek1/chk1 and chek2/chk2/cds1 kinases, and stabilization of tp53 and apoptosis. atm and chek2 may also be activated independently by a parallel pathway mediated by tp53bp1.
5166	derived from proteolytic degradation of complement c4, c4a anaphylatoxin is a mediator of local inflammatory process. it induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
5167	
5168	hydrolyzes n(g),n(g)-dimethyl-l-arginine (adma) and n(g)-monomethyl-l-arginine (mma) which act as inhibitors of nos. has therefore a role in nitric oxide generation.
5169	
5170	receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
5171	plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
5172	binds to scaffold/matrix attachment region (s/mar) dna and forms a molecular assembly point to allow the formation of a @#$%&transcriptosomal@#$%& complex (consisting of sr proteins and rna polymerase ii) coupling transcription and rna processing.
5173	
5174	enhances nf-kappa-b, srf and ap1 transactivation.
5175	
5176	probably involved in connections of major cytoskeletal structures to the plasma membrane.
5177	interconverts glcnac-6-p and glcnac-1-p.
5178	this protein specifically binds to the dna sequence 5@#$%&- gggactttcc-3@#$%& which is found in the enhancer elements of numerous viral promoters such as those of sv40, cmv, or hiv1. in addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class i mhc, interleukin-2 receptor, and interferon-beta genes. it may act in t-cell activation.
5179	tumor suppressor that may be involved in interferon- dependent cell death (by similarity).
5180	induces cartilage and bone formation.
5181	phm and phv also cause vasodilation.
5182	inhibitor of hgf activator. also acts as an inhibitor of matriptase (st14).
5183	major connective tissue mitoattractant secreted by vascular endothelial cells. promotes proliferation and differentiation of chondrocytes. mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. enhances fibroblast growth factor-induced dna synthesis.
5184	protein kinase that plays an important role in cellular stress response. activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic foxo3a. phosphorylates nedd4l, which leads to its inactivation and to the subsequent activation of various channels and transporters such as enac, kv1.3, or eaat1.
5185	
5186	
5187	inhibits dna replication by preventing the incorporation of mcm complex into prereplication complex (pre-rc). it is degraded during the mitotic phase of the cell cycle. its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
5188	induces cartilage and bone formation.
5189	
5190	mediates potential-dependent transport of a variety of organic cations. may play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
5191	
5192	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
5193	insulin decreases blood glucose concentration. it increases cell permeability to monosaccharides, amino acids and fatty acids. it accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
5194	
5195	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
5196	forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
5197	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l.
5198	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l.
5199	may modulate the internalization of beta-amyloid precursor protein.
5200	single-stranded nucleic acid binding protein that binds preferentially to oligo dc (by similarity).
5201	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
5202	active on amp and damp with atp as a donor. when gtp is used as phosphate donor, the enzyme phosphorylates amp, cmp, and to a small extent dcmp.
5203	may be an activator of the jnk/sapk pathway. phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
5204	catalyzes the formation of gdp-l-fucose from gtp and l- fucose-1-phosphate. functions as a salvage pathway to reutilize l- fucose arising from the turnover of glycoproteins and glycolipids.
5205	
5206	
5207	helicase; has atpase activity.
5208	receptor for members of the ephrin-b family.
5209	
5210	
5211	
5212	may play a role in b-lineage commitment and/or modulation of signaling through the b-cell receptor.
5213	
5214	factor h functions as a cofactor in the inactivation of c3b by factor i and also increases the rate of dissociation of the c3bbb complex (c3 convertase) and the (c3b)nbb complex (c5 convertase) in the alternative complement pathway.
5215	
5216	
5217	straight-chain enoyl-coa thioesters from c4 up to at least c16 are processed, although with decreasing catalytic rate.
5218	involved in mrna splicing and in the nonsense mediated decay (nmd) pathway.
5219	
5220	cell surface receptor for reelin (reln) and apolipoprotein e (apoe)-containing ligands. lrp8 participates in transmitting the extracellular reelin signal to intracellular signaling processes, by binding to dab1 on its cytoplasmic tail. reelin acts via both the vldl receptor (vldlr) and lrp8 to regulate dab1 tyrosine phosphorylation and microtubule function in neurons. lrp8 has higher affinity for reelin than vldlr. lrp8 is thus a key component of the reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. binds the endoplasmic reticulum resident receptor-associated protein (rap). binds dimers of beta 2-glycoprotein i and may be involved in the suppression of platelet aggregation in the vasculature. highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (phgpx), two proteins required for sperm maturation. may also function as an endocytic receptor.
5221	possible role in vesicle-mediated transport. may be involved in proper membrane localization of rab gtpases.
5222	
5223	
5224	
5225	
5226	
5227	required for meiotic chromosome synapsis and cell cycle progression. may act as a molecular zipper to bring homologous chromosomes in close apposition. zip1 may encode the transverse filaments of the synaptonemal complex.
5228	orphan receptor; possibly for a chemokine.
5229	
5230	
5231	recruited and tyrosine phosphorylated by several receptor systems, for example the t-cell, leptin and insulin receptors. once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to sh2 and sh3 domain- containing proteins. role in g2-m progression in the cell cycle. represses cbp-dependent transcriptional activation apparently by competing with other nuclear factors for binding to cbp. also acts as a putative regulator of mrna stability and/or translation rates and mediates mrna nuclear export. isoform 3 is only expressed in growth-arrested cells and inhibits s phase entry.
5232	this small ubiquitous enzyme is essential for maintenance and cell growth.
5233	
5234	converts multiple adenosines to inosines and creates i/u mismatched base pairs in double-helical rna substrates without apparent sequence specificity. has been found to modify more frequently adenosines in au-rich regions, probably due to the relative ease of melting a/u base pairs as compared to g/c pairs. functions to modify viral rna genomes and may be responsible for hypermutation of certain negative-stranded viruses. edits the messenger rnas for glutamate receptor (glur) subunits by site- selective adenosine deamination. produces low-level editing at the glur-b q/r site, but edits efficiently at the r/g site and hotspot1. binds to short interfering rnas (sirna) without editing them and suppresses sirna-mediated rna interference. binds to ilf3/nf90 and upregulates ilf3-mediated gene expression.
5235	
5236	required for stability of pex5 and protein import into the peroxisome matrix. anchored by pex26 to peroxisome membranes, possibly to form heteromeric aaa atpase complexes required for the import of proteins into peroxisomes.
5237	involved in the maintenance of golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and golgi. involved in hormone-induced steroid biosynthesis in testicular leydig cells (by similarity).
5238	anchors the lamina and the heterochromatin to the inner nuclear membrane.
5239	
5240	
5241	may play a role in vesicular transport from endoplasmic reticulum to golgi.
5242	cleaves ubiquitin fusion protein substrates. binds to the herpes virus protein vmw110 which may therefore modulate its substrate specificity or activity to stabilize viral proteins.
5243	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
5244	efficient protease with alanine specificity but only little elastolytic activity.
5245	
5246	
5247	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
5248	part of the dynein complex of respiratory cilia.
5249	receptor for glutamate. the activity of this receptor is mediated by a g-protein that inhibits adenylate cyclase activity.
5250	
5251	phosphorylates ptdins and ptdins4p with a preference for ptdins. does not phosphorylate ptdins(4,5)p2. may be involved in egf and pdgf signaling cascades.
5252	receptor for the fc region of igg. binds complexed or aggregated igg and also monomeric igg. mediates antibody-dependent cellular cytotoxicity (adcc) and other antibody-dependent responses, such as phagocytosis.
5253	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. activity on g(z)-alpha is inhibited by phosphorylation of the g-protein. activity on g(z)-alpha and g(i)-alpha-1 is inhibited by palmitoylation of the g-protein.
5254	seems to mediate adhesion by cell surface integrin binding. may serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment.
5255	
5256	rna-binding protein that binds to several small cytoplasmic rna molecules known as y rnas. may stabilize these rnas from degradation.
5257	may be involved in transcriptional regulation.
5258	binds to tgf-beta. could be involved in capturing and retaining tgf-beta for presentation to the signaling receptors.
5259	functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. upon ligand activation through the released notch intracellular domain (nicd) it forms a transcriptional activator complex with rbp-j kappa and activates genes of the enhancer of split locus. affects the implementation of differentiation, proliferation and apoptotic programs (by similarity).
5260	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
5261	
5262	inhibitory effect on stress fiber organization. may down-regulate rho-like gtpase in hematopoietic cells.
5263	may play a role in encephalic photoreception.
5264	
5265	involved in the regulation of the microtubule (mt) filament system by destabilizing microtubules. it prevents assembly and promotes disassembly of microtubules.
5266	muscle contraction.
5267	endogenous ligand for sulfonylurea receptor. by inhibiting sulfonylurea from binding to the receptor, it reduces k(atp) channel currents and thereby stimulates insulin secretion.
5268	sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. also binds to collagen iv and perlecan. it probably has a role in cell- extracellular matrix interactions.
5269	
5270	
5271	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. participates in pre-mrna splicing. may play a role in the assembly of the u4/u5/u6 tri-snrnp complex. may act as a chaperone.
5272	
5273	
5274	the first ptpase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
5275	
5276	
5277	
5278	
5279	adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. can bind to fibrinogen, fibronectin, laminin and type v collagen.
5280	
5281	
5282	significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (cdnb).
5283	may function as a dna-binding transcription factor. binds to the macrophage-specific tpa-responsive element (mte) of the hmox1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
5284	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking among different compartments. modulates vesicle budding and uncoating within the golgi complex. deactivation induces the redistribution of the entire golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. in its gtp-bound form, its triggers the association with coat proteins with the golgi membrane. the hydrolysis of arf1-bound gtp, which is mediated by arfgaps proteins, is required for dissociation of coat proteins from golgi membranes and vesicles.
5285	essential for recycling gmp and indirectly, cgmp.
5286	
5287	
5288	involved in the cell-cell adhesion. has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with igsf4, pvrl1 and pvrl3. interaction with epb41l1 may regulate structure or function of cell-cell junctions (by similarity).
5289	
5290	
5291	seems to act on cbl. may play a role in regulating the function of cbl and its associated protein kinases.
5292	may play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath (by similarity).
5293	binds to the fc region of immunoglobulins gamma. low affinity receptor. by binding to igg it initiates cellular responses against pathogens and soluble antigens.
5294	
5295	
5296	
5297	
5298	binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with e1, e2, and e3 (by similarity).
5299	motor required for the retrograde transport of golgi vesicles to the endoplasmic reticulum. has a microtubule plus end- directed motility.
5300	
5301	
5302	may regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-er compartment.
5303	may play a role in the signal transduction pathway mediated by multiple wnt genes.
5304	
5305	involved in the degradation of asparagine-linked glycoproteins. hydrolyze of n-acetyl-beta-d-glucosamine (1-4)n- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.
5306	belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (ajs). may connect the nectin-afadin and e- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at ajs through afadin and alpha-actinin (by similarity).
5307	hydrolyzes n(g),n(g)-dimethyl-l-arginine (adma) and n(g)-monomethyl-l-arginine (mma) which act as inhibitors of nos. has therefore a role in nitric oxide generation.
5308	
5309	catalyzes the 6-electron oxidation of protoporphyrinogen ix to form protoporphyrin ix.
5310	plays an important role in the de novo pathway of purine nucleotide biosynthesis.
5311	
5312	
5313	circadian regulator that may act as a transcription factor. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition. the expression rhythms appear to originate from retina (by similarity).
5314	
5315	its physiological substrate seems to be the small heat shock protein (hsp27/hsp25). in vitro can phosphorylate glycogen synthase at ser-7 and tyrosine hydroxylase (on ser-19 and ser-40). this kinase phosphorylates ser in the peptide sequence, hyd-x-r- x(2)-s, where hyd is a large hydrophobic residue (by similarity). mediates both erk and p38 mapk/mapk14 dependent neutrophil responses. participates in tnf alpha-stimulated exocytosis of secretory vesicles in neutrophils. plays a role in phagocytosis- induced respiratory burst activity.
5316	synthesis and degradation of fructose 2,6-bisphosphate.
5317	this receptor binds polymeric iga and igm at the basolateral surface of epithelial cells. the complex is then transported across the cell to be secreted at the apical surface. during this process a cleavage occurs that separate the extracellular (known as the secretory component) from the transmembrane segment (by similarity).
5318	
5319	transcription factor that recognizes and binds to the enhancer heptamer motif 5@#$%&-tga[cg]tca-3@#$%&.
5320	promotes neurite outgrowth of both axons and dendrites (by similarity).
5321	exchange factor for gtp-binding proteins rhoa, rhog and, to a lesser extent, rac1. binds physically to the nucleotide-free states of those gtpases.
5322	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
5323	
5324	functions as a sorting receptor in the golgi compartment and as a clearance receptor on the cell surface. required for protein transport from the golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (m6pr). also required for protein transport from the golgi apparatus to the endosomes. promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of bdnf (probdnf) and ngfb (prongfb). also acts as a receptor for neurotensin. may promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular lpl. probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter slc2a4/glut4 (glut4 storage vesicles, or gsvs). these vesicles provide a stable pool of slc2a4 and confer increased responsiveness to insulin. may also mediate transport from the endoplasmic reticulum to the golgi.
5325	
5326	seems to act exclusively upon threonine residues (by similarity).
5327	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
5328	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. ladsin exerts cell- scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.
5329	
5330	
5331	
5332	transcriptional repressor of genes that require a bhlh protein for their transcription (by similarity).
5333	may act as a modulator against excess calcium accumulation in normal human mammary epithelial cells. may also play a role in suppressing tumor cell growth.
5334	
5335	adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. mediates activation of nf-kappa-b and probably jnk. seems to be involved in apoptosis.
5336	catalyzes the deimination of arginine residues of proteins (by similarity).
5337	
5338	
5339	may play a role in the regulation of t and b-lymphocyte development and signal transduction.
5340	regulates myosin phosphatase activity. augments ca(2+) sensitivity of the contractile apparatus.
5341	catalyzes the conversion of phosphatidic acid (pa) to diacylglycerol (dg). in addition it hydrolyzes lysophosphatidic acid (lpa), ceramide-1-phosphate (c-1-p) and sphingosine-1- phosphate (s-1-p). the relative catalytic efficiency is lpa = pa > c-1-p > s-1-p. may be involved in cell adhesion and in cell-cell interactions.
5342	required for protein transport from the er to the golgi complex.
5343	
5344	promotes the fragmentation of the mitochondrial network and its perinuclear clustering. can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. also mediates peroxisomal fission.
5345	
5346	
5347	
5348	binds preferentially to underphosphorylated retinoblastoma protein.
5349	
5350	
5351	
5352	
5353	part of a complex implicated in the control of actin polymerization in cells.
5354	calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. is not activated by phorbol esters or diaglycerol. may play a role in the secretory response to nutrients. involved in cell polarization processes and the formation of epithelial tight junctions.
5355	
5356	
5357	
5358	
5359	
5360	inhibits interleukin-2 (il-2) gene expression. may be responsible for transcriptional repression of the il-2 gene. enhances or represses the promoter activity of the atp1a1 gene depending on the quantity of cdna and on the cell type.
5361	
5362	
5363	may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
5364	
5365	required for the proper development and maintenance of neurons presumably by affecting rna metabolism.
5366	
5367	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
5368	
5369	
5370	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i.
5371	appears to have dual functions such as cytoplasmic retention of attached nf-kappa-b proteins and generation of p52 by a cotranslational processing. the proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-b consensus sequence 5@#$%&-ggrnnyycc-3@#$%&, located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. isoform p49 is a subunit of the nf-kappa-b protein complex, which stimulates the hiv enhancer in synergy with p65.
5372	
5373	
5374	
5375	
5376	provides the precursors necessary for dna synthesis. catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
5377	involved in mitochondrial transcription regulation. required for accurate and efficient promoter recognition by the mitochondrial rna polymerase. activates transcription by binding immediately upstream of transcriptional start sites. is able to unwind and bend dna.
5378	membrane-cytoskeleton linker. the neural-specific isoforms may participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of ranvier and axonal initial segments.
5379	
5380	involved in cell adhesion. may be involved in the attachment of the actin-based microfilaments to the plasma membrane.
5381	major isoenzyme hydrolyzing the calcium-mobilizing second messenger ins(1,4,5)p3, this is a signal-terminating reaction.
5382	required for kinetochore localization of bub1.
5383	involved in skeletal muscle regeneration, specifically at the onset of cell fusion. also involved in macrophage-derived giant cells (mgc) and osteoclast formation from mononuclear precursors (by similarity).
5384	
5385	
5386	component of multiple cytoplasmic organelles. apparently crucial for their normal development and function. may be involved in intracellular protein sorting.
5387	
5388	
5389	histone methyltransferase. methylates lys-9 of histone h3 and weakly histone h1 (in vitro). h3 lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting hp1 proteins to methylated histones. may participate in regulation of higher order chromatin organization during spermatogenesis.
5390	histone methyltransferase. methylates lys-9 of histone h3 and weakly histone h1 (in vitro). h3 lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting hp1 proteins to methylated histones. may participate in regulation of higher order chromatin organization during spermatogenesis.
5391	
5392	membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. binds to calmodulin.
5393	
5394	binds dna through the consensus sequence 5@#$%&-caatg-3@#$%&. may be involved in transcriptional regulation and may play a role in tooth formation (by similarity).
5395	catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a thr-glu-tyr sequence located in map kinases. activates erk1 and erk2 map kinases.
5396	
5397	
5398	may act as scaffold protein (by similarity). may play a role in the development of the retina. has been suggested to play a role in axon guidance.
5399	
5400	
5401	
5402	cleaves the propeptides of type i and ii collagen prior to fibril assembly. does not act on type iii collagen. may also play a role in development that is independent of its role in collagen biosynthesis.
5403	
5404	
5405	
5406	
5407	may be involved in the maintenance of the endoplasmic reticulum-golgi intermediate compartment and golgi structures. overexpression perturbs endoplasmic reticulum-golgi intermediate compartment and golgi structures.
5408	
5409	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
5410	
5411	could be involved in bone formation.
5412	
5413	
5414	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
5415	
5416	required for membrane traffic to the vacuole.
5417	
5418	
5419	voltage insensitive, instantaneous, outwardly rectifying potassium channel. outward rectification is reversed at high external k(+) concentrations.
5420	putative transcription factor. involved in hair formation and spermatogenesis. may function in the differentiation and/or maintenance of the urogenital system (by similarity).
5421	may contribute to the organization of cell structure. the sh3 motif may function as a binding region to cytoskeleton. tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.
5422	essential for the control of the cell cycle at the g1/s (start) transition.
5423	
5424	cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (by similarity).
5425	
5426	may be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. able to restore partial locomotion and axonal fasciculation to c.elegans unc-76 mutants in germ-line transformation experiments.
5427	
5428	adapter involved in the tlr4 signaling pathway in the innate immune response. acts via irak2 and traf-6, leading to the activation of nf-kappa-b, mapk1, mapk3 and jnk, resulting in cytokine secretion and the inflammatory response.
5429	
5430	
5431	may play a role in the regulation of hemostasis. the soluble form may have inhibitory properties towards coagulation factors. may interact with cellular g-protein signaling pathways. may bind to the dna 5@#$%&-gtcacatg-3@#$%&(cdei box).
5432	
5433	implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.
5434	
5435	
5436	component of e3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. seems to be involved poteosomal degradation of p53/tp53 stimulated by adenovirus e1b-55 kda protein. may form a cell surface vasopressin receptor.
5437	
5438	
5439	the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-coa and co(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (e1), dihydrolipoamide acetyltransferase (e2) and lipoamide dehydrogenase (e3).
5440	this protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
5441	involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26s proteasome (by similarity).
5442	likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the rxxx[kr]r consensus motif.
5443	the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the er, via the golgi up to the trans golgi network. coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-er transport of dilysine-tagged proteins. in mammals, the coatomer can only be recruited by membranes associated to adp-ribosylation factors (arfs), which are small gtp-binding proteins; the complex also influences the golgi structural integrity, as well as the processing, activity, and endocytic recycling of ldl receptors (by similarity).
5444	
5445	
5446	
5447	binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with e1, e2, and e3 (by similarity).
5448	
5449	reversible hydration of carbon dioxide.
5450	receptor for il-10; binds il-10 with a high affinity.
5451	inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. this suggests that it delays the catabolism of triglyceride-rich particles.
5452	participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (lcat).
5453	cytokine receptor that binds to blc. blr1 exerts possibly a regulatory function in burkitt lymphoma (bl) lymphomagenesis and/or b-cell differentiation. it is a potential candidate for cell-cell interaction, and activation of mature b- lymphocytes in lymphatic tissues.
5454	
5455	it is able to complement the radiosensitivity defect of an ataxia telangiectasia (at) fibroblast cell line.
5456	
5457	
5458	may regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-er compartment.
5459	
5460	
5461	may play a role in vesicular protein sorting, similar to the yeast retromer proteins (by similarity).
5462	
5463	
5464	
5465	
5466	may be involved in signal transduction as a component of a multimeric receptor complex.
5467	
5468	cleaves the glcnac-asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
5469	cleaves the glcnac-asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
5470	cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the glc(2)man(9)glcnac(2) oligosaccharide precursor of immature glycoproteins.
5471	membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. it plays a role in fatty-acid desaturation and is also involved in several steps of the sterol biosynthesis pathway, particularly in the 4- demethylation of the 4,4@#$%&-dimethyl zymosterol.
5472	may be involved in the regulation of gene expression as repressor and activator. the repression might be related to covalent modification of histone proteins.
5473	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
5474	receptor-proximal protein kinase regulating integrin- mediated signal transduction. may act as a mediator of inside-out integrin signaling. focal adhesion protein part of the complex ilk-pinch. this complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also akt1 and gsk3b.
5475	
5476	converts sphingomyelin to ceramide. asm also has phospholipase c activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.
5477	
5478	may have e3 ubiquitin ligase activity.
5479	
5480	
5481	
5482	nup98 and nup96 play a role in the bidirectional transport across the nucleoporin complex (npc). the repeat domain in nup98 has a direct role in the transport.
5483	ucp are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. as a result, energy is dissipated in the form of heat. may play a role in the modulation of tissue respiratory control. participates in thermogenesis and energy balance.
5484	
5485	
5486	
5487	hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. does not have reverse activity.
5488	upstream regulator of interferon-induced serine/threonine protein kinase r (pkr). may block the pkr- inhibitory function of p58ipk, resulting in restoration of kinase activity and suppression of cell growth.
5489	
5490	
5491	plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.
5492	protein transport. regulator of membrane traffic from the golgi apparatus towards the endoplasmic reticulum (er). has a low gtpase activity.
5493	
5494	
5495	
5496	
5497	may play a role in the er-associated degradation of misfolded glycoproteins.
5498	
5499	golgi auto-antigen; probably involved in maintaining golgi structure.
5500	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
5501	
5502	endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). may also play a role in neovascularization or angiogenesis. hydrolyzes collagen type iv, laminin, nidogen, nascin-c isoform, fibronectin, and type i gelatin.
5503	mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.
5504	
5505	
5506	component of the dystrophin-glycoprotein complex (dgc), a complex that spans the muscle plasma membrane and forms a link between the f-actin cytoskeleton and the extracellular matrix. preferentially associates with the sarcoglycan subcomplex of the dgc.
5507	receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
5508	important for chromosome transmission and normal cell cycle progression in g(2)/m. could be an atp-dependent dna-binding helicase.
5509	important for chromosome transmission and normal cell cycle progression in g(2)/m. could be an atp-dependent dna-binding helicase.
5510	
5511	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
5512	causes the formation of thin, actin-rich surface projections called filopodia. functions cooperatively with cdc42 and rac to generate additional structures, increasing the diversity of actin-based morphology.
5513	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
5514	the beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating g protein inhibition and controlling the alpha-1 subunit membrane targeting.
5515	in vitro; can phosphorylate exogenous substrates on ser and thr residues. may be involved in the regulation of cellular growth and/or development.
5516	major cellular poly(rc)-binding protein. binds also poly(ru).
5517	morphine modulating peptides. have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. neuropeptide ff potentiates and sensitizes accn2 and accn3 channels.
5518	
5519	
5520	
5521	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
5522	
5523	
5524	selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
5525	subunit of atp-sensitive potassium channels (katp). can form cardiac and smooth muscle-type katp channels with kir6.2. kir6.2 forms the channel pore while sur2 is required for activation and regulation.
5526	plays a role as a receptor for the recognition of mhc class i hla-e molecules by nk cells and some cytotoxic t-cells.
5527	transcriptional activator. able to bind to two different type of dna binding sites. isoform foxj2.l behaves as a more potent transactivator than foxj2.s.
5528	component of the polycomb group (pcg) multiprotein prc1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including hox genes, throughout development. pcg prc1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone h2a lys-119, rendering chromatin heritably changed in its expressibility.
5529	transport of phosphorylated lysosomal enzymes from the golgi complex and the cell surface to lysosomes. lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low ph mediates the dissociation of the complex.
5530	
5531	
5532	
5533	associates with the organic matrix of bone and cartilage. thought to act as an inhibitor of bone formation.
5534	the s.cerevisiae ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-amp.
5535	
5536	
5537	
5538	
5539	may be involved in transcriptional regulation.
5540	may play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation.
5541	
5542	involved in several cell fate decisions that require cell-cell interactions. it is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10.
5543	may be involved in the pdh (pyruvate dehydrogenase complex) bypass.
5544	interacts with the viral protein-binding domain of the retinoblastoma protein.
5545	interacts with the viral protein-binding domain of the retinoblastoma protein.
5546	
5547	protein phosphatase 1 (pp1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. involved in regulation of ionic conductances and long-term synaptic plasticity. may play an important role in dephosphorylating substrates such as the postsynaptic density-associated ca(2+)/calmodulin dependent protein kinase ii.
5548	protein phosphatase 1 (pp1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. involved in regulation of ionic conductances and long-term synaptic plasticity. may play an important role in dephosphorylating substrates such as the postsynaptic density-associated ca(2+)/calmodulin dependent protein kinase ii.
5549	involved in the regulation of cell growth. may stabilize the active cdc2-cyclin b1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. may act as tumor suppressor.
5550	gtpase-activating protein for the adp ribosylation factor family.
5551	
5552	ribosomal protein p0 is the functional equivalent of e.coli protein l10.
5553	possesses gtpase activity.
5554	possesses gtpase activity.
5555	ampk is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-coa carboxylase. also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-coa reductase and hormone- sensitive lipase. this is a regulatory subunit, may be a positive regulator of ampk activity. it may also serve as an adaptor molecule for the catalytic alpha-subunit.
5556	degrades ubl1 and smt3h2 conjugates and releases the monomers. acts on sumoylated pml.
5557	regulates myosin phosphatase activity.
5558	
5559	interacts specifically with a number of opioid ligands. receptor for neuropeptides b and w, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. has a higher affinity for neuropeptide b.
5560	
5561	
5562	cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in dna repair, and in apoptosis. the cohesin complex is required for the cohesion of sister chromatids after dna replication. the cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. at metaphase-anaphase transition, this protein is cleaved by espl1 and dissociates from chromatin, allowing sister chromatids to segregate. the cohesin complex may also play a role in spindle pole assembly during mitosis. also plays a role in apoptosis, via its cleavage by caspase-3/casp3 or caspase-7/casp7 during early steps of apoptosis: the c-terminal 64 kda cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
5563	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
5564	
5565	
5566	
5567	involved in g1 arrest. may mediate tgf beta-induced g1 arrest. binds to and inhibits complexes formed by cyclin e-cdk2, cyclin a-cdk2, and cyclin d1-cdk4. interaction with nucleoporin nup50 is required for nuclear import and for degradation of phosphorylated p27kip1 after nuclear import (by similarity).
5568	suppressor of apoptosis.
5569	forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
5570	
5571	
5572	cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. also permeable for ca(2+), li(+) and k(+). generates a biphasic current with a fast inactivating and a slow sustained phase. mediates glutamate-independent ca(2+) entry into neurons upon acidosis. this ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. heteromeric channel assembly seems to modulate channel properties.
5573	
5574	produces nitric oxide (no) which is a messenger molecule with diverse functions throughout the body. in the brain and peripheral nervous system, no displays many properties of a neurotransmitter.
5575	
5576	
5577	orphan nuclear receptor. represses transcription and binds dna as a homodimer. binds the ir7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism (by similarity).
5578	function in general translation initiation by promoting the binding of the formylmethionine-trna to ribosomes. seems to function along with eif-2.
5579	
5580	actin-binding protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia.
5581	probably acts as a regulator of other genes. forms a complex with adenovirus e1a and with sv40 large t antigen. acts as a tumor suppressor. may bind and modulate functionally certain cellular proteins with which t and e1a compete for pocket binding. potent inhibitor of e2f-mediated trans-activation. recruits and targets histone methyltransferase suv39h1 leading to epigenetic transcriptional repression. inhibits the intrinsic kinase activity of taf1.
5582	
5583	potential calcium-dependent cell-adhesion protein.
5584	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
5585	binds to type ii regulatory subunits of protein kinase a and anchors/targets them.
5586	
5587	may have a growth inhibitory role.
5588	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
5589	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
5590	
5591	
5592	functions in nuclear protein import as nuclear transport receptor. serves as receptor for nuclear localization signals (nls) in cargo substrates. is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (npc) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus (by similarity). mediates the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones.
5593	play an important role in cellular zinc homeostasis as a zinc transporter. regulated in response to zinc availability (by similarity).
5594	
5595	type iv collagen is the major structural component of glomerular basement membranes (gbm), forming a @#$%&chicken-wire@#$%& meshwork together with laminins, proteoglycans and entactin/nidogen.
5596	
5597	potential calcium-dependent cell-adhesion protein.
5598	
5599	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
5600	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
5601	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
5602	probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. may play a role in determining or maintaining the identities of a small subset of visual system neurons.
5603	factor xa is a vitamin k-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor va, calcium and phospholipid during blood clotting.
5604	
5605	
5606	may be involved in tissue injury and remodeling. has significant elastolytic activity. can accept large and small amino acids at the p1@#$%& site, but has a preference for leucine. aromatic or hydrophobic residues are preferred at the p1 site, with small hydrophobic residues (preferably alanine) occupying p3 (by similarity).
5607	
5608	involved in the regulation of growth and apoptosis. mediates activation of stress-responsive mtk1/mekk4 mapkkk.
5609	involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
5610	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
5611	
5612	catalyzes the hydrolysis of gtp bound to the 40s ribosomal initiation complex (40s.mrna.met-trna[f].eif-2.gtp) with the subsequent joining of a 60s ribosomal subunit resulting in the release of eif-2 and the guanine nucleotide. the subsequent joining of a 60s ribosomal subunit results in the formation of a functional 80s initiation complex (80s.mrna.met-trna[f]).
5613	
5614	
5615	
5616	
5617	inhibits activated protein c as well as plasminogen activators.
5618	
5619	
5620	
5621	
5622	
5623	may be a mediator of metastasis suppression in breast carcinoma (by similarity).
5624	plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. sequence-specific dna-binding protein with a distinct binding specificity (by similarity).
5625	
5626	
5627	acts at e2f-responsive promoters to integrate signals provided by phd- and/or bromodomain-containing transcription factors (by similarity).
5628	sodium-independent, high-affinity transport of large neutral amino acids. has higher affinity for l-phenylalanine that lat1. l-alanine is transported at physiological concentrations. plays a role in basolateral (re)absorption of neutral amino acids.
5629	probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. may be involved in the uptake of lipoprotein apoe in liver (by similarity).
5630	
5631	
5632	
5633	this rnase has marked specificity towards the 3@#$%& side of uridine nucleotides.
5634	
5635	pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
5636	
5637	
5638	
5639	
5640	
5641	
5642	
5643	may play a role in the response to environmental stress. appears to act upstream of the jun n-terminal pathway.
5644	may play a role in organizing the actin cytoskeleton of the brain cells.
5645	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
5646	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. activity on g(o)-alpha is specifically enhanced by the rgs6/gbeta5 dimer.
5647	probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as notch receptors and app (beta-amyloid precursor protein). requires the other members of the gamma-secretase complex to have a protease activity. may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. stimulates cell-cell adhesion though its association with the e-cadherin/catenin complex. under conditions of apoptosis or calcium influx, cleaves e-cadherin promoting the disassembly of the e-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating wnt signaling. may also play a role in hematopoiesis.
5648	the 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-coa and co(2). it contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (e1), dihydrolipoamide succinyltransferase (e2) and lipoamide dehydrogenase (e3).
5649	
5650	tumor-suppressor protein involved in t-cell lymphomas. may function on the p53-signaling pathway. may be a key regulator of both differentiation and survival during thymocyte development. repress transcription through direct, tfcoup2-independent binding to a gc-rich response element (by similarity).
5651	may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (by similarity).
5652	may enhance gap-43 expression by binding to the ngf- regulatory region of its mrna (by similarity).
5653	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
5654	
5655	
5656	
5657	
5658	
5659	
5660	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. may be involved in the remodeling of the actin cytoskeleton. binds actin with high affinity both in the absence and presence of atp and its mechanochemical activity is inhibited by calcium ions. also acts as a gtpase activating protein on rho.
5661	might act as an e3 ubiquitin-protein ligase, or as part of the e3 complex, which accepts ubiquitin from specific e2 ubiquitin-conjugating enzymes, such as ube2l3/ubcm4, and then transfers it to substrates.
5662	transcription factor that may have a role in the regulation of signaling pathways intrinsic to the photoreceptor cell function.
5663	may be involved in transcriptional regulation.
5664	
5665	receptor for neurotrophin-3 (nt-3). this is a tyrosine- protein kinase receptor. known substrates for the trk receptors are shc1, pi-3 kinase, and plcg1. the different isoforms do not have identical signaling properties.
5666	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
5667	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
5668	
5669	
5670	recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. seems to be the key enzyme in the formation of an ra gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (by similarity).
5671	
5672	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
5673	integrin alpha-11/beta-1 is a receptor for collagen.
5674	catalyzes the first committed step in the biosynthesis of complex n-glycans. it controls conversion of high mannose to complex n-glycans; the final hydrolytic step in the n-glycan maturation pathway.
5675	
5676	
5677	
5678	
5679	
5680	
5681	
5682	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. most active in catalyzing 2-hydroxylation. caffeine is metabolized primarily by cytochrome cyp1a2 in the liver through an initial n3-demethylation. also acts in the metabolism of aflatoxin b1 and acetaminophen.
5683	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. most active in catalyzing 2-hydroxylation. caffeine is metabolized primarily by cytochrome cyp1a2 in the liver through an initial n3-demethylation. also acts in the metabolism of aflatoxin b1 and acetaminophen.
5684	
5685	
5686	co-chaperone of hsc70. seems to play a role in protein import into mitochondria.
5687	multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. required for the progression from the g1 to the s phase. anti-apoptotic protein which functions as a caspase-3 inhibitor. has no phosphatase 2a (pp2a) inhibitor activity (by similarity).
5688	adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. can bind to fibrinogen, fibronectin, laminin, type v collagen and integrins alpha-v/beta-1, alpha- v/beta-3 and alpha-iib/beta-3.
5689	
5690	
5691	type i collagen is a member of group i collagen (fibrillar forming collagen).
5692	could be involved in cell-cell interactions.
5693	could be involved in cell-cell interactions.
5694	could be involved in cell-cell interactions.
5695	could be involved in cell-cell interactions.
5696	
5697	
5698	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
5699	
5700	e-cad/ctf2 promotes non-amyloidogenic degradation of abeta precursors. has a strong inhibitory effect on app c99 and c83 production.
5701	
5702	the nuclear isoform (1/nop30) may be involved in rna splicing and the cytoplasmic isoform (2/myp) may inhibit apoptosis.
5703	
5704	
5705	
5706	
5707	dna repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. may be involved in interstrand dna cross-link repair and in the maintenance of normal chromosome stability.
5708	
5709	attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to na-k atpase, to the lymphocyte membrane protein gp85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. in skeletal muscle, isoform mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
5710	probably involved in the biogenesis of the cox complex.
5711	have a function in liver regeneration and spermatogenesis (by similarity).
5712	
5713	
5714	binds fibroblast growth factor and e-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils).
5715	
5716	phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin i. the beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation.
5717	
5718	this is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters. may be considered as a novel component of the nf-kappa-b signaling axis responsible for the survival and activation of b-cells after bcr cross-linking (by similarity).
5719	
5720	
5721	
5722	sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. controls the reabsorption of sodium in kidney, colon, lung and sweat glands. also plays a role in taste perception.
5723	the enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin k-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
5724	
5725	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (by similarity).
5726	cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases (by similarity).
5727	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
5728	
5729	
5730	involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl coa ester.
5731	
5732	
5733	
5734	
5735	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
5736	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
5737	integrin alpha-l/beta-2 is a receptor for icam1, icam2, icam3 and icam4. it is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic t-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
5738	the 3beta-hsd enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. hsd vii is active against four 7alpha-hydroxylated sterols. does not metabolize several different c(19/21) steroids as substrates. involved in bile acid synthesis.
5739	
5740	
5741	
5742	probable component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. may be required to regulate the atp- dependent activity (by similarity).
5743	binds to the n-terminal pts2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.
5744	
5745	
5746	muscle contraction.
5747	catalyzes the desaturation of very long chain acyl-coas to 2-trans-enoyl-coas.
5748	
5749	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. has angiogenic inhibitor activity (by similarity). active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture (by similarity).
5750	possible transcription factor. specifically binds to the ct/gc-rich region of the interleukin-3 promoter and mediates tax transactivation of il-3.
5751	
5752	involved in the homologous recombination repair (hrr) pathway of double-stranded dna breaks arising during dna replication or induced by dna-damaging agents. the rad51b-rad51c dimer exhibits single-stranded dna-dependent atpase activity. the bcdx2 complex binds single-stranded dna, single-stranded gaps in duplex dna and specifically to nicks in duplex dna.
5753	
5754	
5755	produced by macrophages, ifn-alpha have antiviral activities. interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
5756	
5757	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. socs3 is involved in negative regulation of cytokines that signal through the jak/stat pathway. inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, lif, erythropoietin, insulin, il12, gcsf and leptin receptors. binding to jak2 inhibits its kinase activity. suppresses fetal liver erythropoiesis. regulates onset and maintenance of allergic responses mediated by t-helper type 2 cells. regulates il-6 signaling in vivo (by similarity).
5758	
5759	functions as an androgen transport protein, but may also be involved in receptor mediated processes. each dimer binds one molecule of steroid. specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
5760	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
5761	type i collagen is a member of group i collagen (fibrillar forming collagen).
5762	c8 is a constituent of the membrane attack complex. c8 binds to the c5b-7 complex, forming the c5b-8 complex. c5-b8 binds c9 and acts as a catalyst in the polymerization of c9. the gamma subunit seems to be able to bind retinol.
5763	component of a protein kinase signal transduction cascade. mediates activation of the nf-kappa-b, ap1 and ddit3 transcriptional regulators.
5764	component of a protein kinase signal transduction cascade. mediates activation of the nf-kappa-b, ap1 and ddit3 transcriptional regulators.
5765	
5766	similar to that of somatotropin.
5767	
5768	
5769	similar to that of somatotropin.
5770	
5771	associated to surface igm-receptor; may be involved in signal transduction.
5772	
5773	
5774	may play a role in intracellular protein transport. may be involved in the translocation of app along microtubules toward the cell surface.
5775	
5776	
5777	
5778	lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of nf-kappa-b and its transcriptional activity. induces the processing of nf-kappa-b 2/p100. could act in a receptor-selective manner (by similarity).
5779	
5780	the physiological role for the icosapeptide has not yet been elucidated.
5781	
5782	
5783	carries out a dual function: signal transduction and activation of transcription. binds to the gas element and activates prl-induced transcription.
5784	
5785	
5786	
5787	
5788	chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. may play a role in neoplasia and inflammatory host responses. this protein can bind heparin. the processed form mcp-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of ccl7, and also of ccl2 and ccl5 and ccl8.
5789	appears to have dual functions such as cytoplasmic retention of attached nf-kappa-b proteins and generation of p50 by a cotranslational processing. the proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of nfkb1/p105 also appears to occur posttranslationally. p50 binds to the kappa-b consensus sequence 5@#$%&-ggrnnyycc-3@#$%&, located in the enhancer region of genes involved in immune response and acute phase reactions. plays a role in the regulation of apoptosis.
5790	
5791	may act as an inducible transporter in the biliary and intestinal excretion of organic anions.
5792	probably involved in the control of the cell cycle. interacts with cyclins a, b3, d, or e. activity of cdk2 is maximal during s phase and g2.
5793	type i collagen is a member of group i collagen (fibrillar forming collagen).
5794	involved in the inactivation of map kinases. dephosphorylates erk, jnk and p38 map-kinases.
5795	
5796	transcription factor, probably binds to the inverted palindrome 5@#$%&-gttaatnattaac-3@#$%&.
5797	monokine with inflammatory and chemokinetic properties. binds to ccr5. one of the major hiv-suppressive factors produced by cd8+ t-cells. recombinant mip-1-beta induces a dose-dependent inhibition of different strains of hiv-1, hiv-2, and simian immunodeficiency virus (siv). the processed form mip-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor ccr5 and to inhibit the ccr5- mediated entry of hiv-1 in t-cells. mip-1-beta(3-69) is also a ligand for ccr1 and ccr2 isoform b.
5798	shows chemotactic activity for lymphocytes and monocytes but not neutrophils. also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. recombinant scya16 shows chemotactic activity for monocytes and thp-1 monocytes, but not for resting lymphocytes and neutrophils. induces a calcium flux in thp-1 cells that were desensitized by prior expression to rantes.
5799	stimulates the gtpase activity of ras. nf1 shows greater affinity for ras gap, but lower specific activity. may be a regulator of ras activity.
5800	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
5801	
5802	
5803	
5804	calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. phosphorylates camk1, camk1d, camk1g and camk4. involved in regulating cell apoptosis. promotes cell survival by phosphorylating akt1/pkb that inhibits pro-apoptotic bad/bcl2-antagonist of cell death.
5805	active toward esters of long-chain and very-long chain fatty acids such as palmitoyl-coa and stearoyl-coa.
5806	has an atp-independent isopeptidase activity, cleaving at the c-terminus of the ubiquitin moiety. in vitro, isoform 2, but not isoform 3, shows deubiquitinating activity.
5807	
5808	
5809	
5810	nuclear hormone receptor. high affinity receptor for triiodothyronine.
5811	regulates the gdp/gtp exchange reaction of the rho proteins by inhibiting the dissociation of gdp from them, and the subsequent binding of gtp to them (by similarity).
5812	
5813	involved in the transduction of mitogenic signals from the cell membrane to the nucleus. may play a role in the postsynaptic responses of hippocampal neuron.
5814	most effectively accelerate the intrinsic gtpase activity of ypt7. it is also active, but to a lesser extent, on ypt31, ypt32 and ypt1. ypt6 and sec4.
5815	acts as a coactivator in the regulation of translation initiation of poly(a)-containing mrnas. its stimulatory activity on translation is mediated via its action on pabpc1. competes with paip2 for binding to pabpc1. its association with eif4a and pabpc1 may potentiate contacts between mrna termini. may also be involved in translationally coupled mrna turnover. implicated with other rna-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding-region determinant of instability (mcrd) domain.
5816	
5817	this is a receptor for retinoic acid. this metabolite has profound effects on vertebrate development. retinoic acid is a morphogen and is a powerful teratogen. this receptor controls cell function by directly regulating gene expression.
5818	
5819	required maternally for proper expression of other homeotic genes involved in pattern formation, such as ubx.
5820	collagen type iv is specific for basement membranes. vital for embryonic development.
5821	
5822	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling.
5823	
5824	calcium-permeable, non-selective cation channel with an outward rectification. seems to be regulated, at least in part, by igf-i, pdgf and neuropeptide head activator. may transduce physical stimuli in mast cells. activated by temperatures higher than 52 degrees celsius; is not activated by vanilloids and acidic ph.
5825	
5826	
5827	may play a role in vesicle trafficking.
5828	
5829	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.
5830	
5831	part of the signal peptidase complex (spc), exact function is not known (by similarity).
5832	may be involved in transcriptional regulation.
5833	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
5834	this protein is associated with nerve growth. it is a major component of the motile @#$%!growth cones@#$%! that form the tips of elongating axons.
5835	may function as a transcription factor. seems to repress transcription.
5836	
5837	
5838	the classic group of mbp isoforms (isoform 4-isoform 14) are with plp the most abundant protein components of the myelin membrane in the cns. they have a role in both its formation and stabilization. the smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. the non- classic group of mbp isoforms (isoform 1-isoform 3/golli-mbps) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in t- cells and neural cells. differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.
5839	
5840	tumor suppressor. it blocks the growth, invasion, and metastatic properties of mammary tumors. as it does not undergo the s (stressed) to r (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
5841	suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. regulates cell death by controlling the mitochondrial membrane permeability. appears to function in a feedback loop system with caspases. inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1).
5842	involved in innate immune defense against viruses. upon interaction with intracellular dsrna produced during viral replication, triggers a transduction cascade involving mavs, which results in the activation of nf-kappa-b, irf3 and irf7 and the induction of the expression of antiviral cytokines such as ifn- beta and rantes (ccl5). essential for the production of interferons in response to rna viruses including paramyxoviruses, influenza viruses and japanese encephalitis virus (by similarity).
5843	
5844	may be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
5845	low affinity receptor to n-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. binding of fmlp to the receptor causes activation of neutrophils. this response is mediated via a g-protein that activates a phosphatidylinositol-calcium second messenger system.
5846	adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. preferentially binds to alpha2,3- linked sialic acid (by similarity).
5847	
5848	may be involved in transcriptional regulation.
5849	the intermediate chains seem to help dynein bind to dynactin 150 kda component.
5850	
5851	
5852	
5853	
5854	component of the very low density lipoprotein (vldl) fraction in plasma, and is an activator of several triacylglycerol lipases. the association of apoc2 with plasma chylomicrons, vldl, and hdl is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.
5855	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
5856	fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
5857	
5858	
5859	
5860	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
5861	may function as a signal transducer between specific cell types of mesodermal origin.
5862	
5863	receptor for trypsin and trypsin-like enzymes coupled to g proteins that stimulate phosphoinositide hydrolysis.
5864	binds to scaffold/matrix attachment region (s/mar) dna and forms a molecular assembly point to allow the formation of a @#$%&transcriptosomal@#$%& complex (consisting of sr proteins and rna polymerase ii) coupling transcription and rna processing (by similarity). can function as an estrogen receptor corepressor and can also bind to the hsp27 promoter and decrease its transcription. can inhibit cell proliferation.
5865	calcium-dependent mitochondrial solute carrier (by similarity).
5866	
5867	binds avidly to the au-rich element in fos and il3/interleukin-3 mrnas. in the case of the fos au-rich element, hur binds to a core element of 27 nucleotides that contain auuua, auuuua, and auuuuua motifs.
5868	probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. may mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. probably recognizes in a calcium-dependent manner high mannose n-linked oligosaccharides in a variety of pathogen antigens, including hiv-1 gp120, hiv-2 gp120, siv gp120, ebolavirus glycoproteins, hcv e2, and human sars coronavirus protein s. is a receptor for icam3, probably by binding to mannose-like carbohydrates. is presumably a coreceptor for the sars coronavirus.
5869	receptor for class i mhc antigens. recognizes a broad spectrum of hla-a, hla-b, hla-c and hla-g alleles. involved in the down-regulation of the immune response and the development of tolerance. competes with cd8a for binding to class i mhc antigens. inhibits fcgr1a-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
5870	type i collagen is a member of group i collagen (fibrillar forming collagen).
5871	catalyzes the conversion of 3-methylglutaconyl-coa to 3- hydroxy-3-methylglutaryl-coa. has very low enoyl-coa hydratase activity. was originally identified as rna-binding protein that binds in vitro to clustered 5@#$%&-auuua-3@#$%& motifs.
5872	
5873	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
5874	calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. receptor propably implicated in the regulation of exocytosis (by similarity).
5875	
5876	
5877	
5878	
5879	seems to be an adapter protein in the postsynaptic density (psd) of excitatory synapses that interconnects receptors of the postsynaptic membrane including nmda-type and metabotropic glutamate receptors via complexes with gkap/psd-95 and homer, respectively, and the actin-based cytoskeleton. may play a role in the structural and functional organization of the dendritic spine and synaptic junction.
5880	induces sprouting in endothelial cells through an autocrine and paracrine action.
5881	
5882	transfers the glycosyl residue from udp-glc to the nonreducing end of alpha-1,4-glucan.
5883	
5884	transcription activator for a number of liver genes such as afp, albumin, tyrosine aminotransferase, pepck, etc. interacts with the cis-acting regulatory regions of these genes.
5885	binds specifically to peptidoglycan and is involved in innate immunity.
5886	
5887	
5888	upon binding to egf receptor enhances egf-dependent mitogenic signals. can bind multiple cellular targets.
5889	
5890	catalytic subunit of the peripheral v1 complex of vacuolar atpase. v-atpase vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
5891	catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a thr-glu-tyr sequence located in map kinases. activates the erk1 and erk2 map kinases (by similarity).
5892	
5893	
5894	
5895	general protein kinase capable of phosphorylating several known proteins.
5896	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
5897	may play a role in both peripheral and central nervous system development (by similarity).
5898	
5899	may play a regulatory role in synaptic vesicle recycling.
5900	transcriptional corepressor that binds to a number of transcription factors. inhibits the transcriptional activation mediated by ctnnb1 and tcf family members in wnt signaling. the effects of full-length tle family members may be modulated by association with dominant-negative aes (by similarity).
5901	histone methyltransferase. methylates lys-9 of histone h3 (in vitro). h3 lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting hp1 proteins to methylated histones. probably targeted to histone h3 by different dna-binding proteins like e2f6, mga, max and/or dp1. during g0 phase, it probably contributes to silencing of myc- and e2f-responsive genes, suggesting a role in g0/g1 transition in cell cycle.
5902	
5903	may be involved in control of cell shape.
5904	seems to play a role in testicular function. may be a trophic hormone with a role in testicular descent in fetal life. is a ligand for lgr8 receptor.
5905	plays a role in a process governing chromosomal dynamics during mitosis (by similarity).
5906	
5907	mediates b-cell b-cell interactions. may be involved in the localization of b-cells in lymphoid tissues. binds sialylated glycoproteins; one of which is cd45. preferentially binds to alpha2,6-linked sialic acid. the sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of b-cell antigen receptor signaling. plays a role in positive regulation through interaction with src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their sh2 domains that block signal transduction through dephosphorylation of signaling molecules.
5908	
5909	the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the er, via the golgi up to the trans golgi network. coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-er transport of dilysine-tagged proteins. in mammals, the coatomer can only be recruited by membranes associated to adp-ribosylation factors (arfs), which are small gtp-binding proteins; the complex also influences the golgi structural integrity, as well as the processing, activity, and endocytic recycling of ldl receptors (by similarity).
5910	may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. when overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor (n-linked stearoyl- (c18) ceramide) in a fumonisin b1-independent manner (by similarity).
5911	cytochromes p450 are a group of heme-thiolate monooxygenases. this enzyme requires molecular oxygen and nadph for the omega-hydroxylation of ltb4, a potent chemoattractant for polymorphonuclear leukocytes.
5912	
5913	
5914	
5915	
5916	binding protein for activin and bmp-2 (by similarity).
5917	
5918	
5919	essential for the control of the cell cycle at the g1/s (start) transition.
5920	
5921	
5922	enzyme with a broad specificity. dephosphorylates cdk2 and cdk6 in vitro.
5923	may regulate vesicle trafficking and modulate the subcellular distribution of slc2a4/glut4-vesicles. has parp activity and can modify terf1, and thereby contribute to the regulation of telomere length.
5924	
5925	regulatory subunit of the cyclin-dependent kinase pair (cdk9/cyclin t) complex, also called positive transcription elongation factor b (p-tefb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the ctd (carboxy-terminal domain) of the large subunit of rna polymerase ii (rnap ii). does not bind efficiently to the transactivation domain of the hiv-1 nuclear transcriptional activator, tat.
5926	the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-coa and co(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (e1), dihydrolipoamide acetyltransferase (e2) and lipoamide dehydrogenase (e3).
5927	circadian regulator that may act as a transcription factor. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition. expression oscillates with a 24 hour rhythm in the suprachiasmatic nucleus (scn) and the whole eyes. oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. there is a 4 hour time delay between per1 and per2 oscillations. the expression rhythms appear to originate from retina (by similarity).
5928	
5929	
5930	
5931	
5932	apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. acts as an inhibitor of tnfrsf6 mediated apoptosis. a proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (disc) thereby blocking further recruitment and processing of caspase-8 at the complex. full length and shorter isoforms have been shown either to induce apoptosis or to reduce tnfrsf-triggered apoptosis. lacks enzymatic (caspase) activity.
5933	isoform c is proteolytically inactive.
5934	
5935	promotes the exchange of gsp1/gsp2-bound gdp by gtp. involved in yeast pheromone response pathway and in mrna metabolism. probably involved in the control of nuclear organization.
5936	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
5937	
5938	
5939	
5940	
5941	
5942	
5943	catalyzes the production of gaba.
5944	
5945	participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development.
5946	
5947	
5948	
5949	
5950	major protein kinase c substrate of platelets, its exact function is not known.
5951	protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton. promotes formation of stress fibers and of focal adhesion complexes. plays a role in smooth muscle contraction (by similarity).
5952	
5953	
5954	required for autophagy.
5955	
5956	
5957	component of the nuclear body, also known as nuclear domain 10, pml oncogenic domain, and kr body. may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.
5958	
5959	
5960	acts as a regulatory subunit of the 26 proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
5961	
5962	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. associates with polr2g.
5963	this is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.
5964	acts as a transcriptional repressor for zinc finger transcription factors egr1 and egr2 (by similarity).
5965	
5966	
5967	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters.
5968	
5969	cell surface proteoglycan that bears heparan sulfate.
5970	may be involved in regulating membrane traffic to and from trans-golgi network.
5971	
5972	antimicrobial protein that kills intracellular pathogens. active against a broad range of microbes, including gram-positive and gram-negative bacteria, fungi, and parasites. kills mycobacterium tuberculosis.
5973	muscle contraction.
5974	
5975	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. rna polymerase i is essentially used to transcribe ribosomal dna units.
5976	
5977	
5978	
5979	
5980	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation via its interaction with the myocyte enhancer factors such as mef2a, mef2c and mef2d.
5981	
5982	
5983	
5984	plays a key role in retinoic acid metabolism. acts on retinoids, including all-trans-retinoic acid (ra) and its stereoisomer 9-cis-ra. capable of both 4-hydroxylation and 18- hydroxylation. responsible for generation of several hydroxylated forms of ra, including 4-oh-ra, 4-oxo-ra and 18-oh-ra.
5985	plays a key role in retinoic acid metabolism. acts on retinoids, including all-trans-retinoic acid (ra) and its stereoisomer 9-cis-ra. capable of both 4-hydroxylation and 18- hydroxylation. responsible for generation of several hydroxylated forms of ra, including 4-oh-ra, 4-oxo-ra and 18-oh-ra.
5986	
5987	
5988	integrin alpha-6/beta-1 is a receptor for laminin on platelets. integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
5989	transcription factor involved in the induction of oxygen regulated genes. binds to core dna sequence 5@#$%&-[ag]cgtg-3@#$%& within the hypoxia response element (hre) of target gene promoters. regulates the vascular endothelial growth factor (vegf) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. may also play a role in the formation of the endothelium that gives rise to the blood brain barrier. potent activator of the tie-2 tyrosine kinase expression. activation seems to require recruitment of transcriptional coactivators such as crebpb and probably ep300. interaction with redox regulatory protein apex seems to activate ctad.
5990	
5991	may function as signaling molecule. isoform 2 may be involved in cell growth and tumorigenesis.
5992	
5993	
5994	
5995	
5996	
5997	
5998	involved in the de novo synthesis of guanine nucleotides which are not only essential for dna and rna synthesis, but also provide gtp, which is involved in a number of cellular processes important for cell division.
5999	
6000	may be a regulatory subunit of cytochrome c oxidase that mediates the higher level of energy production in target cells by estrogen.
6001	effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. focal adhesion protein part of the complex ilk-pinch. this complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway.
6002	
6003	gtpase-activating protein (gap) for the adp ribosylation factor 1 (arf1). involved in membrane trafficking and /or vesicle transport. promotes hydrolysis of the arf1-bound gtp and thus, is required for the dissociation of coat proteins from golgi-derived membranes and vesicles, a prerequisite for vesicle@#$%&s fusion with target compartment. probably regulates arf1-mediated transport via its interaction with the kdelr proteins and rnp24. overexpression induces the redistribution of the entire golgi complex to the endoplasmic reticulum, as when arf1 is deactivated. its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (by similarity).
6004	
6005	probably important in the regulation of neuronal excitability. associates with kcnq3 to form a potassium channel with essentially identical properties to the channel underlying the native m-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. kcnq2/kcnq3 current is blocked by linopirdine and xe991, and activated by the anticonvulsant retigabine. muscarinic agonist oxotremorine-m strongly suppress kcnq2/kcnq3 current in cells in which cloned kcnq2/kcnq3 channels were coexpressed with m1 muscarinic receptors.
6006	may play a role in the molecular organization of synapses and neuronal cell signaling. could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. may induce enrichment of psd-95/sap90 at the plasma membrane.
6007	plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity.
6008	polycomb group (pcg) protein. pcg proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. participates to the etv6-mediated repression. probably plays a role in cell proliferation. overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
6009	
6010	
6011	neutrophil and pancreatic elastase-specific inhibitor of skin. it may prevent elastase-mediated tissue proteolysis.
6012	
6013	may play a role in transcription elongation or in coupling transcription to pre-mrna processing through its association with the phosphorylated c-terminal domain (ctd) of rnapii largest subunit.
6014	
6015	may have a role in the regulation of spermatogenesis.
6016	
6017	
6018	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
6019	may be involved in transcriptional regulation.
6020	
6021	
6022	this protein mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient. it is a tetrodotoxin-resistant na(+) channel isoform. this channel is responsible for the initial upstroke of the action potential in the electrocardiogram.
6023	
6024	this is the smallest of the 5 chains of the enzymatic component (coupling factor cf(1)) of the mitochondrial atpase complex (by similarity).
6025	
6026	may act in the sexual differentiation pathway (by similarity).
6027	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters. it binds to a tax-responsive enhancer element in the long terminal repeat of htlv-i.
6028	
6029	
6030	may be involved in cell-surface proteolysis, cell adhesion or intracellular protein maturation.
6031	
6032	t-snare involved in the molecular regulation of neurotransmitter release. may play an important role in the synaptic function of specific neuronal systems. associates with proteins involved in vesicle docking and membrane fusion.
6033	ligand for multiple notch receptors and involved in the mediation of notch signaling. may be involved in cell-fate decisions during hematopoiesis. seems to be involved in early and late stages of mammalian cardiovascular development. inhibits myoblast differentiation (by similarity). enhances fibroblast growth factor-induced angiogenesis (in vitro).
6034	
6035	
6036	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
6037	phosphorylase is an important allosteric enzyme in carbohydrate metabolism. enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. however, all known phosphorylases share catalytic and structural properties.
6038	
6039	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
6040	
6041	calretinin is a calcium-binding protein which is abundant in auditory neurons.
6042	
6043	
6044	may regulate transcriptional activity.
6045	binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate.
6046	modulates transcriptional activation by steroid receptors such as nr3c1, nr3c2 and esr1. also modulates transcriptional repression by nuclear hormone receptors.
6047	
6048	
6049	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (by similarity). has angiogenic inhibitor activity. active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture.
6050	transcriptional regulator that acts as repressor or activator. binds, in-vitro, to nf-e2 binding sites. play important roles in coordinating transcription activation and repression by mafk.
6051	possible transcription factor.
6052	required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. cooperates with olig1 to establish the pmn domain of the embryonic neural tube. antagonist of v2 interneuron and of nkx2-2-induced v3 interneuron development (by similarity).
6053	receptor for interferons alpha and beta. isoform 1 and isoform 3 are directly involved in signal transduction due to their interaction with the tyr kinase, jak1. isoform 1 also interacts with the transcriptional factors, stat1 and stat2. both forms are potent inhibitors of type i ifn activity.
6054	
6055	transcription factor that may be a master gene of cns development in cooperation with arnt. it may have pleiotropic effects in the tissues expressed during development.
6056	
6057	
6058	cell adhesion molecule that can mediate cation- independent homophilic binding activity. could be involved in nervous system development.
6059	
6060	plays a role in transcriptional coactivation.
6061	editing of the messenger rnas for glutamate receptor (glur) subunits by site-selective adenosine deamination. edits both the glur-b q/r and r/g sites efficiently but converts the adenosine in hotspot1 much less efficiently.
6062	endostatin potently inhibits endothelial cell proliferation and angiogenesis. may inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
6063	catalyzes the reaction that attaches fucose through an o-glycosidic linkage to a conserved serine or threonine residue in thrombospondin type 1 repeats.
6064	collagen vi acts as a cell-binding protein.
6065	probably methylates the guanidino nitrogens of arginyl residues in some proteins. may play a role in transcriptional coactivation.
6066	probably methylates the guanidino nitrogens of arginyl residues in some proteins. may play a role in transcriptional coactivation.
6067	catalyzes the cyclization of (s)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
6068	
6069	probable protease. seems to be capable of activating enac.
6070	
6071	
6072	required for 7-methylguanosine modification of trna.
6073	
6074	inhibits the dna-binding activity of c/ebp and lap by forming heterodimers that cannot bind dna.
6075	probable transcriptional regulator involved in developmental processes. is required for normal development of the pharyngeal arch arteries (by similarity).
6076	
6077	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
6078	
6079	structural protein (cytoskeletal).
6080	
6081	
6082	displays serine/threonine-specific phosphorylation of myelin basic protein and histone (mbp) in vitro.
6083	
6084	
6085	degrades extracellular matrix. exhibits trypsin-like activity as defined by cleavage of synthetic substrates with arg or lys as the p1 site (by similarity).
6086	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l (by similarity).
6087	
6088	receptor for somatostatins-14 and -28. this receptor is coupled via pertussis toxin sensitive g proteins to inhibition of adenylyl cyclase. in addition it stimulates phosphotyrosine phosphatase and plc via pertussis toxin insensitive as well as sensitive g proteins. in rin-5f cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.
6089	
6090	component of the scf (skp1-cul1-f-box protein) and the cbc(vhl) (cul2-elonging bc-vhl) e3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. through the ring-type zinc finger, seems to recruit the e2 ubiquitination enzyme, like cdc34, to the complex and brings it into close proximity to the substrate. probably also stimulates cdc34 autoubiquitination. promotes the neddylation of cul1 and probably cul2.
6091	
6092	involved in cytokinesis (potential).
6093	involved in the synthesis of the gdp-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (by similarity).
6094	
6095	
6096	
6097	
6098	incorporated into fibronectin-containing matrix fibers. may play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ecm). could be important for certain developmental processes and contribute to the supramolecular organization of ecm architecture, in particular to those of basement membranes. has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. may play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. could play a significant role in modulating the neurotrophic activities of app, particularly soluble app.
6099	
6100	suppresses neurite outgrowth (by similarity).
6101	may be a transporter. may act as a non-selective neuronal cation channel.
6102	
6103	probably involved in nervous system development and function.
6104	
6105	recruits tfiih to the initiation complex and stimulates the rna polymerase ii c-terminal domain kinase and dna-dependent atpase activities of tfiih. both tfiih and tfiie are required for promoter clearance by rna polymerase.
6106	
6107	gtpase-activating protein for the adp ribosylation factor family (potential).
6108	may be involved in transcriptional regulation. involved in cell differentiation and/or proliferation.
6109	
6110	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
6111	
6112	
6113	receptor for angiotensin ii. mediates its action by association with g proteins that activate a phosphatidylinositol- calcium second messenger system.
6114	catalyzes the adenylation by atp of the carboxyl- terminal glycine of this.
6115	
6116	connects cell membrane constituents to the actin cytoskeleton. may promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. anchors various transmembrane proteins to the actin cytoskeleton. interaction with flna may allow neuroblast migration from the ventricular zone into the cortical plate. various interactions and localizations of isoforms affect myotube morphology and myogenesis. isoform 6 accelerates muscle differentiation in vitro.
6117	
6118	forms hydroxylysine residues in -xaa-lys-gly- sequences in collagens. these hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen crosslinks.
6119	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters.
6120	
6121	
6122	seems to act exclusively upon threonine residues (by similarity).
6123	
6124	
6125	component of a putative tumor-recognition complex. involved in the function of nk cells.
6126	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
6127	essential multidomain scaffolding protein required for normal development (by similarity). recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. may play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.
6128	involved in iron cellular uptake. seems to be internalized and then recycled back to the cell membrane. binds a single atom of iron per subunit. could also bind zinc.
6129	
6130	
6131	activates ubiquitin by first adenylating with atp its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in e1, yielding an ubiquitin-e1 thioester and free amp.
6132	
6133	
6134	rna-binding protein, which is essential for gametogenesis. plays a central role during spermatogenesis. may act by binding to the 3@#$%&utr of mrna and thereby regulating the translation of key transcripts (by similarity).
6135	catalyzes the initial reaction in o-linked oligosaccharide biosynthesis, the transfer of an n-acetyl-d- galactosamine residue to a serine or threonine residue on the protein receptor. although it displays a much weaker activity toward all substrates tested compared to galnt2, it is able to transfer up to seven galnac residues to the muc5ac peptide, suggesting that it can fill vicinal thr/ser residues incorporation with other galnt proteins. prefers muc1a as substrate.
6136	
6137	nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity (by similarity).
6138	
6139	in peripheral tissues, the h1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
6140	
6141	
6142	the long isoform may play a role in neural and glial cell adhesion in the developing embryo. the short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. vital for embryonic development. essential for septate junctions. septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. required for the blood-brain barrier formation.
6143	(1) kininogens are inhibitors of thiol proteases; (2) hmw-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor xi next to factor xii; (3) hmw-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from hmw-kininogen shows a variety of physiological effects: (4a) influence in smooth muscle contraction, (4b) induction of hypotension, (4c) natriuresis and diuresis, (4d) decrease in blood glucose level, (4e) it is a mediator of inflammation and causes (4e1) increase in vascular permeability, (4e2) stimulation of nociceptors (4e3) release of other mediators of inflammation (e.g. prostaglandins), (4f) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) lmw-kininogen inhibits the aggregation of thrombocytes; (6) lmw- kininogen is in contrast to hmw-kininogen not involved in blood clotting.
6144	component of the bactericidal ra-reactive factor rarf which specifically binds to ra and r2 polysaccharides expressed by certain enterobacteria. it triggers the activation of complement cascade by activating the c4 and c2 components. it activates the c4 component by cleaving the alpha-chain of c4.
6145	
6146	
6147	
6148	may act as a negative regulator of ras-mediated mitogenic activity.
6149	type i collagen is a member of group i collagen (fibrillar forming collagen).
6150	
6151	receptor for the mcp-1, mcp-3 and mcp-4 chemokines. transduces a signal by increasing the intracellular calcium ions level. alternative coreceptor with cd4 for hiv-1 infection.
6152	receptor for chemokine scya25/teck. subsequently transduces a signal by increasing the intracellular calcium ions level. alternative coreceptor with cd4 for hiv-1 infection.
6153	
6154	
6155	
6156	may have a role in promoting tumor progression. may block the tgfb1-enhanced cell growth.
6157	may function as a phosphatase involved in the regulation of cell growth and differentiation.
6158	
6159	
6160	has a threefold preference for the hydrolysis of atp over adp.
6161	
6162	involved in ph regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. major proton extruding system driven by the inward sodium ion chemical gradient. plays an important role in signal transduction (by similarity).
6163	
6164	
6165	
6166	transferrins are iron binding transport proteins which can bind two fe(3+) ions in association with the binding of an anion, usually bicarbonate. it is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. serum transferrin may also have a further role in stimulating cell proliferation.
6167	
6168	
6169	required for the fusion of plasma membranes and early endosomes.
6170	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
6171	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
6172	
6173	forms part of the dystrophin-associated protein complex (dapc) which may link the cytoskeleton to the extracellular matrix. alpha-dystroglycan functions as a laminin receptor. binds to several types of arenaviruses. is a target for the entry of mycobacterium leprae into peripheral nerve schwann cells.
6174	
6175	cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. endosomal acidification leads to iron release. the apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral ph and the concomitant loss of affinity of apotransferrin for its receptor. transferrin receptor is necessary for development of erythrocytes and the nervous system (by similarity). a second ligand, the heditary hemochromatosis protein hfe, competes for binding with transferrin for an overlapping c-terminal binding site.
6176	sequence-specific rna-binding protein which participates in the control of pre-mrna splicing.
6177	may have a role in regulating spermiogenesis.
6178	actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells.
6179	does not seem to have ndk kinase activity. confers protection from cell death by bax and alters the cellular levels of several antioxidant enzymes including gpx5. may play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species.
6180	
6181	may modulate the action of some growth factors on cell proliferation and differentiation. binds heparin (by similarity).
6182	
6183	e3 ubiquitin-protein ligase which accepts ubiquitin from specific e2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. negatively regulates tcr (t-cell receptor), bcr (b- cell receptor) and fcer1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. in naive t-cells, inhibits vav1 activation upon tcr engagement and imposes a requirement for cd28 costimulation for proliferation and il-2 production. also acts by promoting pik3r1/p85 ubiquitination, which impairs its recruitment to the tcr and subsequent activation. in activated t- cells, inhibits plcg1 activation and calcium mobilization upon restimulation and promotes anergy. in b-cells, acts by ubiquitinating syk and promoting its proteasomal degradation. may also be involved in egfr ubiquitination and internalization.
6184	
6185	may play a role in microtubule-mediated transport or vesicle function.
6186	specifically phosphorylates the activated forms of g protein-coupled receptors. grk4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin.
6187	
6188	
6189	this oncogene is expressed in neonatal brain. fgf-5 can transform nih 3t3 cells.
6190	positively regulates a late step in synaptic vesicle exocytosis. also involved in glucose-induced secretion of insulin by pancreatic beta-cells (by similarity).
6191	receptor for acidic and basic fibroblast growth factors. preferentially binds fgf1.
6192	may be involved in the control of cell growth and differenciation. may contribute to cancer.
6193	this protein is a minor sialoglycoprotein in erythrocyte membranes.
6194	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
6195	transcriptional modulator activated by bmp (bone morphogenetic proteins) type 1 receptor kinase. smad1 is a receptor-regulated smad (r-smad).
6196	
6197	
6198	
6199	
6200	binds rnas containing the 14 base g-rich element.
6201	
6202	udpgt is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. this isoform is active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.
6203	udpgt is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
6204	
6205	
6206	
6207	induces disassembly of actin filaments in conjunction with adf/cofilin family proteins (by similarity).
6208	functions as a sorting receptor in the golgi compartment and as a clearance receptor on the cell surface. required for protein transport from the golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (m6pr). also required for protein transport from the golgi apparatus to the endosomes. promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of bdnf (probdnf) and ngfb (prongfb). also acts as a receptor for neurotensin. may promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular lpl. probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter slc2a4/glut4 (glut4 storage vesicles, or gsvs). these vesicles provide a stable pool of slc2a4 and confer increased responsiveness to insulin. may also mediate transport from the endoplasmic reticulum to the golgi.
6209	
6210	segment polarity protein, functions together with arm to transduce the wingless (wg) signal. acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
6211	inactivation of prostaglandins.
6212	
6213	
6214	
6215	
6216	involved in regulation of actin cytoskeleton organization and endocytosis.
6217	inactivates paf by removing the acetyl group at the sn-2 position. this is a catalytic subunit. plays an important role during the development of brain.
6218	may contribute to the alteration of neural cellular mechanisms (by similarity).
6219	binds with high affinity to rna molecules that contain au-rich elements (ares) found within the 3@#$%& untranslated regions of many protooncogenes and cytokine mrnas. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain (by similarity).
6220	
6221	probable helicase involved in mitochondrial functions. required for rapid turnover of mrnas containing a premature translational termination codon.
6222	catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. required for the secretion of plasma lipoproteins that contain apolipoprotein b.
6223	
6224	
6225	essential component of the nelf complex, a complex that negatively regulates the elongation of transcription by rna polymerase ii. the nelf complex, which acts via an association with the dsif complex and causes transcriptional pausing, is counteracted by the p-tefb kinase complex. probably required to interact with the rna polymerase ii complex.
6226	involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. transcription factor which could determine a neurotransmitter phenotype in vertebrates. enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including camp-response element and serum- response element.
6227	
6228	
6229	
6230	probable atp-dependent dna helicase.
6231	
6232	binds to the caccc box. may play a role in hematopoiesis (by similarity).
6233	
6234	
6235	the heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.
6236	
6237	
6238	
6239	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
6240	
6241	receptor for vegfc. has a tyrosine-protein kinase activity.
6242	may act as positive axonal guidance cues.
6243	actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. may be down-regulated in neuroblastoma tumors.
6244	this protein promotes the gtp-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome (by similarity).
6245	
6246	general transcription factor. btf3 can form a stable complex with rna polymerase ii. required for the initiation of transcription.
6247	
6248	
6249	
6250	
6251	involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. substrates include pomc, renin, enkephalin, dynorphin, somatostatin and insulin.
6252	specific inhibition of calpain (calcium-dependent cysteine protease). plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
6253	
6254	promotes the exchange of ras-bound gdp by gtp.
6255	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling. phosphorylates ctnnb1 on ser-45.
6256	high affinity receptor for activated thrombin coupled to g proteins that stimulate phosphoinositide hydrolysis. may play a role in platelets activation and in vascular development.
6257	
6258	major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle.
6259	cleaves the propeptides of type i and ii collagen prior to fibril assembly. does not act on type iii collagen. may also play a role in development that is independent of its role in collagen biosynthesis.
6260	may be required for neuronal cell differentiation.
6261	
6262	
6263	
6264	participates in at least several b-cell activation processes as well as of other cell types. it is a costimulator of dna-synthesis. it induces the expression of class ii mhc molecules on resting b-cells. it enhances both secretion and cell surface expression of ige and igg1. it also regulates the expression of the low affinity fc receptor for ige (cd23) on both lymphocytes and monocytes.
6265	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. this subunit, together with cytochrome b, binds to ubiquinone.
6266	likely involved in the mobilization of calcium as a result of the tcr/cd3 complex interaction. binds to cyclophilin b.
6267	not chemotactive for t-cells, b-cells, monocytes, natural killer cells or ghranulocytes. does not inhibit proliferation of myeloid progenitors in colony formation assays.
6268	
6269	
6270	regulates intra- and extracellular levels of inorganic pyrophosphate (ppi), probably functioning as ppi transporter.
6271	actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (by similarity).
6272	
6273	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
6274	
6275	vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
6276	c7 is a constituent of the membrane attack complex. c7 binds to c5b forming the c5b-7 complex, where it serves as a membrane anchor.
6277	
6278	
6279	
6280	
6281	
6282	
6283	
6284	may be involved in macrophage-mediated cellular proliferation. it is mitogenic for fibroblasts and smooth muscle but not endothelial cells. it is able to bind egf receptors with higher affinity than egf itself and is a far more potent mitogen for smooth muscle cells than egf. also acts as a diphtheria toxin receptor.
6285	
6286	interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite dna, called the cenp-b box. may organize arrays of centromere satellite dna into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (by similarity).
6287	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
6288	associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. it may function in the assembly and/or transport of ribosome.
6289	
6290	receptor for glucocorticoids (gc). has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (gre) and as a modulator of other transcription factors. affects inflammatory responses, cellular proliferation and differentiation in target tissues. could act as a coactivator for stat5-dependent transcription upon growth hormone (gh) stimulation and could reveal an essential role of hepatic gr in the control of body growth.
6291	
6292	this is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas.
6293	transcriptional regulator. recognizes and binds to the dna sequence 5@#$%&-cgcccccgc-3@#$%&(egr-site). activates the transcription of target genes whose products are required for mitogenesis and differentiation.
6294	hydrolyzes fatty acids from s-acylated cysteine residues in proteins such as trimeric g alpha proteins or hras. also has low lysophospholipase activity.
6295	catalyzes the s-methylation of thiopurine drugs such as 6-mercaptopurine.
6296	plus end-directed microtubule-dependent motor protein involved in mannnose-6-phosphate receptor (m6pr) transport to the plasma membrane (by similarity).
6297	
6298	
6299	
6300	
6301	type xii collagen interacts with type i collagen- containing fibrils, the col1 domain could be associated with the surface of the fibrils, and the col2 and nc3 domains may be localized in the perifibrillar matrix (by similarity).
6302	protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function.
6303	catalyzes the covalent attachment of ubiquitin to other proteins. seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum.
6304	
6305	marcks is the most prominent cellular substrate for protein kinase c. this protein binds calmodulin, actin, and synapsin. marcks is a filamentous (f) actin cross-linking protein.
6306	
6307	receptor for dopamine. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase. might be involved in the processing of visual information and/or visual learning.
6308	
6309	
6310	
6311	
6312	microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
6313	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
6314	regulates the activity of the neutrophil proteases elastase, cathepsin g and proteinase-3.
6315	
6316	
6317	binds to the metal-regulating-element (mre) of metallothionein-1a gene promoter. binding is zinc-dependent.
6318	transcriptional activator. binds to the interferon- stimulated response element (isre) of the mhc class i promoter. binds the immunoglobulin lambda light chain enhancer, together with pu.1. probably plays a role in isre-targeted signal transduction mechanisms specific to lymphoid cells.
6319	
6320	catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to s-lactoylglutathione.
6321	stimulates the transcription of various genes by recognizing and binding to a ccaat motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
6322	
6323	
6324	may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. it is essential for disk morphogenesis.
6325	essential for the control of the cell cycle at the g1/s (start) transition. potentiates the transcriptional activity of atf5.
6326	
6327	histone h4, along with histone h3, plays a central role in nucleosome formation.
6328	
6329	may be involved in transcriptional regulation.
6330	protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. may constitute a glutathionine peroxidase-like protective system against peroxide damage in sperm membrane lipids.
6331	
6332	seems to play an important role in erythropoiesis.
6333	component of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends.
6334	may act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
6335	may play a role in macrophage activation and function.
6336	
6337	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&. activates transcription of pf4 in complex with meis1.
6338	located at the top of the head of the 40s subunit, it contacts several helices of the 18s rrna (by similarity).
6339	
6340	receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-coa oxidase and activates its transcription. it therefore controls the peroxisomal beta-oxidation pathway of fatty acids. decreases expression of npc1l1 once activated by a ligand.
6341	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins that stimulate adenylate cyclase (by similarity).
6342	
6343	probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. is not an essential protein. involved in substrate recognition in ubiquitin-dependent degradation.
6344	transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.
6345	
6346	this protein specifically binds to the dna sequence 5@#$%&- gggactttcc-3@#$%& which is found in the enhancer elements of numerous viral promoters such as those of sv40, cmv, or hiv1. in addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class i mhc, interleukin-2 receptor, somatostatin receptor ii, and interferon- beta genes. it may act in t-cell activation.
6347	may play a role in anchoring the cytoskeleton to the plasma membrane (by similarity to dystrophin).
6348	may be involved in several stages of intracellular trafficking.
6349	component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnrnp). hnrnp play an important role in processing of precursor mrna in the nucleus.
6350	adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. binding of ap180 to clathrin triskelia induces their assembly into 60-70 nm coats (by similarity).
6351	nad-dependent deacetylase, which participates in a wide range of cellular events including chromosome silencing, chromosome segregation, dna recombination and the determination of life span. involved in transcriptional repression of the silent mating-type loci hml and hmr and telomeric silencing via its association with sir3 and sir4. plays a central role in ribosomal dna (rdna) silencing via its association with the rent complex, preventing hyperrecombination, and repressing transcription from foreign promoters, which contributes to extending life span. probably represses transcription via the formation of heterochromatin structure, which involves the compaction of chromatin fiber into a more condensed form, although this complex in at least one case can still bind euchromatic levels of positive transcription regulators. although it displays some nad-dependent histone deacetylase activity on lys-9 and lys-14 of histone h3 and lys-16 of histone h4 in vitro, such activity is unclear in vivo and may not be essential.
6352	endothelins are endothelium-derived vasoconstrictor peptides.
6353	
6354	
6355	mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons uaa and uag (by similarity).
6356	anchoring protein that mediates the subcellular compartmentation of protein kinase a (pka) and protein kinase c (pkc).
6357	
6358	
6359	probable hydrolase.
6360	transforms 5-carboxymethyl-2-hydroxy-muconic semialdehyde (chms) into 5-carboxymethyl-2-hydroxy-muconic acid (chm).
6361	
6362	
6363	interferes with the binding of transcription factors hif-1a and stat2 to p300/cbp.
6364	required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.
6365	
6366	
6367	
6368	
6369	catalyzes the formation of an hydroxyacyl-coa by addition of water on enoyl-coa. also exhibits 3-hydroxyacyl-coa epimerase and 3-hydroxyacyl-coa dehydrogenase activities. involved in the aerobic and anaerobic degradation of long-chain fatty acids.
6370	functions as an antiadhesin that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion.
6371	
6372	
6373	catalyzes the covalent attachment of ubiquitin to other proteins. capable, in vitro, to ubiquitinate histone h2a.
6374	
6375	
6376	
6377	
6378	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
6379	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
6380	this enzyme is required for electron transfer from nadp to cytochrome p450 in microsomes. it can also provide electron transfer to heme oxygenase and cytochrome b5. may function to clear the olfactory organ (antennae) from accumulating chemicals.
6381	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
6382	
6383	
6384	
6385	
6386	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
6387	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
6388	
6389	tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
6390	required for vacuolar assembly and vacuolar traffic.
6391	
6392	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
6393	
6394	isoform b has an accelerated gef-independent gdp/gtp exchange and an impaired gtp hydrolysis, which is restored partially by gtpase-activating proteins. it is able to bind to the gtpase-binding domain of pak but not full-length pak in a gtp- dependent manner, suggesting that the insertion does not completely abolish effector interaction.
6395	
6396	
6397	
6398	
6399	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
6400	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
6401	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
6402	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
6403	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
6404	
6405	chemotactic for eosinophils and basophils. binds to ccr3.
6406	chemotactic for resting t-lymphocytes, and eosinophils. has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. binds to ccr3.
6407	guanine nucleotide exchange factor (gef) for rap1a, rap2a and mras/m-ras-gtp. its association with mras inhibits rap1 activation.
6408	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
6409	
6410	
6411	has very limited arylesterase and no paraoxonase activities but rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (by similarity).
6412	ligand-activated transcriptional activator. binds to the xre promoter region of genes it activates. activates the expression of multiple phase i and ii xenobiotic chemical metabolizing enzyme genes (such as the cyp1a1 gene). mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. involved in cell-cycle regulation. likely to play an important role in the development and maturation of many tissues.
6413	phosphorylates rs domain-containing proteins, such as sfrs1 and sfrs2 on serine residues. role in spliceosome assembly and in mediating the trafficking of splicing factors. appears to mediate hbv core protein phosphorylation which is a prerequisite for pregenomic rna encapsidation into viral capsids.
6414	
6415	
6416	
6417	probable ligand for integrin in the brain. this is a non catalytic metalloprotease-like protein. involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation.
6418	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
6419	
6420	
6421	
6422	
6423	transcription factor, master regulator of tracheal cell fates in the embryo, necessary for the development of the salivary gland duct and the posterior spiracles. it may induce a general fate of branched tubular structures of epithelial origin. heterodimers of tgo/trh are involved in the control of breathless expression.
6424	
6425	
6426	involved in the transport of chloride ions. may regulate bicarbonate secretion and salvage in epithelial cells by regulating the slc4a7 transporter.
6427	
6428	
6429	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. this is a component of the iron-sulfur (ip) fragment of the enzyme.
6430	
6431	transcriptional repressor that binds to the promoter region of target genes. plays a role in the regulation of the cell cycle and of the wnt pathway. binds preferentially to the sequence 5@#$%&-ttcattcattca-3@#$%&. binding to the h1f0 promoter is enhanced by interaction with rb1. disrupts the interaction between dna and tcf4.
6432	isoform 2/truncated isoform may act as an antagonist.
6433	may be involved in transcriptional regulation.
6434	may be involved in transcriptional regulation.
6435	
6436	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex.
6437	
6438	required for ribosomal rna processing. associates with u3 small nucleolar rna.
6439	may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. binds three calcium ions.
6440	mediates ubiquitination of cellular proteins.
6441	
6442	not yet clear. it is known to be expressed in a variety of tissues and it seems to be able to bind to cells, membranes and hydrophobic proteins. it has been associated with programmed cell death (apoptosis).
6443	
6444	
6445	participates in the regulation of gene transcription. binds dna both in a non-specific manner and also specifically to recognizes the core sequence 5@#$%&-cac[ga]tg-3@#$%&. seems to activate the transcription of growth-related genes.
6446	
6447	
6448	preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone.
6449	mrs4 suppresses a mitochondrial splice defect in the first intron of the cob gene. it may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). not essential.
6450	binds and activates tie2 receptor by inducing its tyrosine phosphorylation. implicated in endothelial developmental processes later and distinct from that of vegf. appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. mediates blood vessel maturation/stability. it may play an important role in the heart early development.
6451	
6452	redirects newly synthesized mhc class i heavy chains via the sec61 translocon to the cytosol where they undergo proteasome- dependent destruction. in consequence, infected cells are masked for immune recognition by cytotoxic t-lymphocytes.
6453	
6454	
6455	
6456	required for protein transport from the er to the golgi complex.
6457	specifically hydroxylates an asp or asn residue in certain epidermal growth factor-like (egf) domains of a number of proteins.
6458	
6459	binds the telomeric double-stranded ttaggg repeat and negatively regulates telomere length. involved in the regulation of the mitotic spindle.
6460	endopeptidase that degrades various components of the extracellular matrix, such as collagen type iii and fibronectin. activates progelatinase a. involved in the matrix remodeling of blood vessels. the short isoform cleaves fibronectin and also collagen type iii, but at lower rate. it has no effect on type i, ii, iv and v collagen. however, upon interaction with cspg4, it may be involved in degradation and invasion of type i collagen by melanoma cells.
6461	promotes guanine-nucleotide exchange on arf1 and arf5. promotes the activation of arf through replacement of gdp with gtp.
6462	membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. two types of receptor subunits exist. these receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (ldl).
6463	
6464	phosphorylates inhibitors of nf-kappa-b thus leading to the dissociation of the inhibitor/nf-kappa-b complex and ultimately the degradation of the inhibitor. also phosphorylates ncoa3 (by similarity).
6465	
6466	
6467	promote mitochondrial fission (by similarity).
6468	probable transcription factor involved in muscle spindle development.
6469	
6470	may play a role in developmental myelination of peripheral nerves.
6471	
6472	ubiquitous transcription factor required for a diverse set of processes. it is a component of the ccr4 complex involved in the control of gene expression (by similarity).
6473	hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
6474	adapter protein, which negatively regulates t-cell receptor (tcr) signaling. inhibits t-cell antigen-receptor induced activation of nuclear factor of activated t-cells. involved in the negative regulation of positive selection and mitosis of t-cells. may act by linking signaling proteins such as zap70 with cbl, leading to a cbl dependent degradation of signaling proteins.
6475	
6476	plays an adhesive role by integrating collagen bundles. it is probably associated with the surface of interstitial collagen fibrils via col1. the col2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large n-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (by similarity).
6477	
6478	belongs to the exosome, a rna-processing complex, which is at least involved in the 3@#$%& processing of the 7s pre-rrna to the mature 5.8s rrna. exhibits a 3@#$%&-5@#$%& exoribonuclease activity (by similarity).
6479	probable transcription regulator.
6480	
6481	may be involved in collagen fiber assembly (by similarity).
6482	may play a role in germ line formation.
6483	recognizes and binds the palindromic sequence 5@#$%&- ttggcnnnnngccaa-3@#$%& present in viral and cellular promoters and in the origin of replication of adenovirus type 2. these proteins are individually capable of activating transcription and replication.
6484	relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. may be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
6485	transports l-glutamate and also l- and d-aspartate. essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. acts as a symport by cotransporting sodium. negatively regulated by arl6ip5 (by similarity).
6486	may be involved in transcriptional regulation.
6487	regulates and initiates biosynthesis of n- acetylneuraminic acid (neuac), a precursor of sialic acids. plays an essential role in early development (by similarity). required for normal sialylation in hematopoietic cells. sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.
6488	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
6489	
6490	
6491	
6492	
6493	binds to regulatory subunit (rii) of protein kinase a. may be involved in establishing polarity in signaling systems or in integrating pka-rii isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by camp (by similarity).
6494	
6495	
6496	
6497	inhibits the transcriptional activity of spi1 in a dose- dependent manner (by similarity).
6498	probable transcription factor. could be involved in thyroid gland organogenesis.
6499	probable transcription factor. could be involved in thyroid gland organogenesis.
6500	dual-specificity phosphatase. preferentially dephosphorylates proteins modified by proline-directed kinases.
6501	
6502	
6503	
6504	
6505	binds to both dna and rna in vitro, with a stronger binding capacity for rna. may represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (by similarity).
6506	
6507	calcium-dependent and glcnac-binding lectin. enhanced phagocytosis of s.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.
6508	
6509	receptor for brain-derived neurotrophic factor (bdnf), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (ngf). involved in the development and/or maintenance of the nervous system. this is a tyrosine-protein kinase receptor. known substrates for the trk receptors are shc1, pi-3 kinase, and plc- gamma-1.
6510	putative function in synaptic vesicle exocytosis by binding to munc18-1, an essential component of the synaptic vesicle exocytotic machinery. may modulate processing of the beta- amyloid precursor protein (app) and hence formation of beta-app.
6511	interacts strongly with cdk4 and cdk6. potent inhibitor. potential effector of tgf-beta induced cell cycle arrest.
6512	activates nf-kappa-b via bcl10.
6513	
6514	
6515	
6516	seems to act exclusively upon threonine residues (by similarity).
6517	
6518	
6519	may play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
6520	adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. mediates activation of nf-kappa-b and jnk and is involved in apoptosis. the traf1/traf2 complex recruits the apoptotic suppressors birc2 and birc3 to tnfrsf1b/tnfr2.
6521	may be involved in vesicular trafficking and neurotransmitter release.
6522	
6523	multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. isoform 2 anti-apoptotic activity is mediated by inhibition of the gzma- activated dnase, nme1. in the course of cytotoxic t-lymphocyte (ctl)-induced apoptosis, gzma cleaves set, disrupting its binding to nme1 and releasing nme1 inhibition. isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2a. isoform 1 and isoform 2 inhibit ep300/crebbp and pcaf-mediated acetylation of histones (hat) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. the predominant target for inhibition is histone h4. hat inhibition leads to silencing of hat-dependent transcription and prevents active demethylation of dna. both isoforms stimulate dna replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.
6524	
6525	neuronal calcium sensor, regulator of g protein-coupled receptor phosphorylation in a calcium dependent manner. directly regulates grk1 (rhok), but not grk2 to grk5. can substitute for calmodulin (by similarity).
6526	
6527	catalyzes the atp-dependent amination of utp to ctp with either l-glutamine or ammonia as the source of nitrogen.
6528	binds directly to 26s ribosomal rna (by similarity).
6529	this small ubiquitous enzyme is essential for maintenance and cell growth.
6530	
6531	involved in low-affinity copper uptake (potential).
6532	histone methyltransferase. methylates lys-9 of histone h3 (in vitro). h3 lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting hp1 proteins to methylated histones. probably targeted to histone h3 by different dna-binding proteins like e2f6, mga, max and/or dp1. during g0 phase, it probably contributes to silencing of myc- and e2f-responsive genes, suggesting a role in g0/g1 transition in cell cycle.
6533	
6534	
6535	
6536	transports nucleotide sugars from the cytosol into golgi vesicles where glycosyltransferases function.
6537	
6538	binds preferentially single-stranded dna and unwinds double stranded dna (by similarity).
6539	critical component of the membrane-bound oxidase of phagocytes that generates superoxide. it is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic nadph across the plasma membrane to molecular oxygen on the exterior. also functions as a voltage-gated proton channel that mediates the h(+) currents of resting phagocytes. it participates in the regulation of cellular ph and is blocked by zinc.
6540	
6541	
6542	noh-1s is a voltage-gated proton channel that mediates the h(+) currents of resting phagocytes and other tissues. it participates in the regulation of cellular ph and is blocked by zinc. noh-1l is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct h(+) ions as part of its electron transport mechanism, whereas noh-1s does not contain an electron transport chain.
6543	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
6544	
6545	probably involved in nervous system development and function.
6546	may have an involvement in muscle development or hypertrophy.
6547	
6548	
6549	
6550	
6551	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
6552	necessary for the synthesis of n-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in gpi-anchor biosynthesis.
6553	may function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. may therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin.
6554	
6555	gtpase activator for the rho-type gtpases by converting them to an inactive gdp-bound state. could regulate the interactions of signaling molecules with the actin cytoskeleton. promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.
6556	this is the non-catalytic component of a yet unknown sodium or proton exchange atpase.
6557	implicated in tumor cell metastasis. may function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction.
6558	
6559	
6560	required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
6561	plays a role in the insulin signaling pathway.
6562	motor protein that translocates prc1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. may play a role in mitotic chromosomal positioning and bipolar spindle stabilization.
6563	
6564	involved in t-cell adhesion processes. it is involved in spontaneous rosette formation with erythrocytes.
6565	transcriptional repressor. binds to caccc-boxes promoter elements.
6566	
6567	not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
6568	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. preferentially uses arachidonate and eicosapentaenoate as substrates.
6569	not known; does not seem to have protease activity as it has lost the active site residues.
6570	
6571	
6572	
6573	
6574	
6575	mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. also required for the transfer of beta-barrel precursors from the tom complex to the sorting and assembly machinery (sam complex) of the outer membrane. acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. the timm8-timm13 complex mediates the import of proteins such as timm23, slc25a12/aralar1 and slc25a13/aralar2, while the predominant timm9-timm10 70 kda complex mediates the import of much more proteins. probably necessary for normal neurologic development.
6576	factor viii, along with calcium and phospholipid, acts as a cofactor for factor ixa when it converts factor x to the activated form, factor xa.
6577	plays a role in modulation of e3 ubiquitin ligase activity of the 2 subunit brca1/bard1 complex.
6578	
6579	protects t-cells from il2 deprivation-induced apoptosis through the inhibition of foxo3a transcriptional activity that leads to the down-regulation of the pro-apoptotic factor bcl2l11. in macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and il10. in t-cells, inhibits anti-cd3-induced nfkb1 nuclear translocation. in vitro, suppresses ap1 and nfkb1 dna-binding activities (by similarity).
6580	controls fundamental aspects of growth and development.
6581	self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
6582	
6583	may supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-golgi network. under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
6584	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
6585	
6586	part of the snapc complex required for the transcription of both rna polymerase ii and iii small-nuclear rna genes. binds to the proximal sequence element (pse), a non-tata-box basal promoter element common to these 2 types of genes. recruits tbp and brf2 to the u6 snrna tata box.
6587	seraspenide inhibits the entry of hematopoeitic pluripotent stem cells into the s-phase (by similarity).
6588	may be involved in chromatin remodeling and transcriptional regulation. may have a role in x inactivation.
6589	
6590	probable atp-dependent rna helicase. may play a role in spermatogenesis.
6591	
6592	catalyzes the reduction of the delta-24 double bond of sterol intermediates. protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. also protects against amyloid-beta peptide-induced apoptosis.
6593	
6594	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to g(i)-alpha and g(o)-alpha, but not to g(s)-alpha. may play a role in regulating the kinetics of signaling in the phototransduction cascade.
6595	inhibits the transcription of ribosomal rna. may inhibits the specific dna binding of ubf1.
6596	
6597	
6598	
6599	seems to plays a role in epithelial tight junction formation. appears early in primordial forms of cell junctions and recruits pard3. the association of the pard6-pard3 complex may prevent the interaction of pard3 with jam1, thereby preventing tight junction assembly (by similarity). plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. involved in platelet activation.
6600	
6601	
6602	
6603	
6604	interacts with the viral protein-binding domain of the retinoblastoma protein.
6605	may play a role in the processes of lymphocyte homing to secondary lymphoid organs.
6606	
6607	
6608	
6609	receptor for mica, micb, ulbp1, ulbp2, ulbp3 (ulbp2>ulbp1>ulbp3) and ulbp4. plays a role as a receptor for the recognition of mhc class i hla-e molecules by nk cells and some cytotoxic t-cells. involved in the immune surveillance exerted by t- and b-lymphocytes.
6610	
6611	
6612	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (by similarity). probably encodes a dihydropyridine-insensitive current. vital for survival to adulthood.
6613	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
6614	desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
6615	required for membrane traffic to the vacuole.
6616	
6617	initiates the extrinsic pathway of blood coagulation. serine protease that circulates in the blood in a zymogen form. factor vii is converted to factor viia by factor xa, factor xiia, factor ixa, or thrombin by minor proteolysis. in the presence of tissue factor and calcium ions, factor viia then converts factor x to factor xa by limited proteolysis. factor viia will also convert factor ix to factor ixa in the presence of tissue factor and calcium.
6618	
6619	may play an integral structural role in elastic-fiber architectural organization and/or assembly.
6620	
6621	overproduction suppresses the slow growth phenotype of cpr7 mutant cells.
6622	
6623	selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
6624	
6625	
6626	involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
6627	serine/threonine protein kinase required for spore wall development.
6628	
6629	
6630	
6631	
6632	
6633	integrin alpha-e/beta-7 is a receptor for e-cadherin. it mediates adhesion of intra-epithelial t-lymphocytes to epithelial cell monolayers.
6634	
6635	interacts with the cytoplasmic tail of nmda receptor subunits and shaker-type potassium channels. required for synaptic plasticity associated with nmda receptor signaling. overexpression or depletion of dlg4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. may reduce the amplitude of accn3 acid-evoked currents by retaining the channel intracellularly. may regulate the intracellular trafficking of adr1b (by similarity).
6636	suppresses g-protein- and mitogen-activated protein kinase-mediated signal transduction.
6637	
6638	
6639	
6640	may facilitate double-stranded rna-regulated gene expression at the level of post-transcription. can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (gcase) and other mrnas and functions at the initiation phase of gcase mrna translation, probably by inhibiting its binding to polysomes. can regulate protein arginine n- methyltransferase 1 activity. may regulate transcription of the il2 gene during t-cell activation. can promote the formation of stable dna-dependent protein kinase holoenzyme complexes on dna.
6641	
6642	
6643	
6644	
6645	
6646	may be involved in transcriptional regulation.
6647	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
6648	adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. alpha adaptin is a subunit of the plasma membrane adaptor. binds polyphosphoinositides (by similarity).
6649	removes 5-oxoproline from various penultimate amino acid residues except l-proline (by similarity).
6650	integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence g-f-p-g-e-r in collagen. integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-v/beta-1 are receptors for fibronectin. alpha-4/beta-1 recognizes one or more domains within the alternatively spliced cs-1 and cs-5 regions of fibronectin. integrin alpha-5/beta-1 is a receptor for fibrinogen. integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. integrin alpha-4/beta-1 is a receptor for vcam1. it recognizes the sequence q-i-d-s in vcam1. integrin alpha-9/beta-1 is a receptor for vcam1, cytotactin and osteopontin. it recognizes the sequence a-e-i-d-g-i-e-l in cytotactin. integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and cspg4. alpha-3/beta-1 may mediate with lgals3 the stimulation by cspg4 of endothelial cells migration. integrin alpha-v/beta-1 is a receptor for vitronectin. beta-1 integrins recognize the sequence r-g-d in a wide array of ligands. isoform beta-1b interferes with isoform beta-1a resulting in a dominant negative effect on cell adhesion and migration (in vitro).
6651	
6652	
6653	functions as a myeloid and b-cell proto-oncogene. may play important roles in leukemogenesis and hematopoiesis. an essential factor in lymphopoiesis, is required for b-cell formation in fetal liver. may function as a modulator of the transcriptional repression activity of arp1 (by similarity).
6654	function in general translation initiation by promoting the binding of the formylmethionine-trna to ribosomes. seems to function along with eif-2 (by similarity).
6655	
6656	
6657	decoy receptor for the cytotoxic ligands tnfs14/light and tnfsf6/fasl. protects against apoptosis.
6658	acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin g. may prevent elastase-mediated damage to oral and possibly other mucosal tissues (by similarity).
6659	
6660	may be involved in transcriptional regulation.
6661	
6662	
6663	
6664	converts lysophosphatidic acid (lpa) into phosphatidic acid by incorporating acyl moiety at the 2 position (by similarity).
6665	
6666	plasma membrane-associated small gtpase which cycles between an active gtp-bound and inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. seems to be involved in the regulation of the nadph oxidase.
6667	plasma membrane-associated small gtpase which cycles between an active gtp-bound and inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. seems to be involved in the regulation of the nadph oxidase.
6668	rna-dependent atpase activity.
6669	
6670	
6671	
6672	could be involved in the repair of interstrand crosslinks.
6673	functions in nuclear protein import as an adapter protein for nuclear receptor kpnb1. binds specifically and directly to substrates containing either a simple or bipartite nls motif. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. in vitro, mediates the nuclear import of human cytomegalovirus ul84 by recognizing a nonclassical nls. in vitro, mediates the nuclear import of human cytomegalovirus ul84 by recognizing a nonclassical nls.
6674	
6675	
6676	component of the chromatin structure remodeling complex (rsc), which is involved in transcription regulation and nucleosome positioning. rsc is responsible for the transfer of a histone octamer from a nucleosome core particle to naked dna. the reaction requires atp and involves an activated rsc-nucleosome intermediate. remodeling reaction also involves dna translocation, dna twist and conformational change. as a reconfigurer of centromeric and flanking nucleosomes, rsc complex is required both for proper kinetochore function in chromosome segregation and, via a pkc1-dependent signaling pathway, for organization of the cellular cytoskeleton. this subunit is involved in meiotic sporulation through regulating ime2 expression.
6677	
6678	may play a role in the signal transduction pathway mediated by multiple wnt genes.
6679	
6680	catalyzes the adenylation by atp of the carboxyl- terminal glycine of this.
6681	the heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.
6682	
6683	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
6684	
6685	
6686	probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment.
6687	calcium-binding protein required for t-cell receptor-, fas-, and glucocorticoid-induced cell death. may mediate ca(2+)- regulated signals along the death pathway (by similarity).
6688	
6689	
6690	
6691	
6692	
6693	
6694	
6695	clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
6696	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
6697	
6698	
6699	e3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. regulates apoptosis by catalyzing the polyubiquitination and degradation of mcl1. also ubiquitinates the p53 tumor suppressor and core histones including h1, h2a, h2b, h3 and h4. binds to an upstream initiator-like sequence in the preprodynorphin gene.
6700	
6701	this alpha-adrenergic receptor mediates its action by association with g proteins that activate a phosphatidylinositol- calcium second messenger system.
6702	
6703	
6704	
6705	may play a role in growth and differentiation of tissues involved in metabolic control. may play a regulatory role during g0/g1 transition of cell growth.
6706	
6707	
6708	non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via g-protein coupled receptor (gpcr) occupancy by ligands such as bombesin or lysophosphatidic acid, or via ldl receptor occupancy. plays a potential role in oncogenic transformations resulting in increased kinase activity.
6709	
6710	associates specifically with huntingtin. this binding is enhanced by an expanded polyglutamine repeat.
6711	likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. may play a role in the differentiation of spermatozoa and oocytes.
6712	this protein participates in processes of transmission and amplification of the visual signal. necessary for the formation of a functional phosphodiesterase holoenzyme.
6713	
6714	key enzyme in the regulation of glycerol uptake and metabolism.
6715	
6716	electrogenic sodium/bicarbonate cotransporter with a na(+):hco3(-) stoichiometry varying from 1:2 to 1:3. may regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular ph.
6717	regulates eif4e activity by preventing its assembly into the eif4f complex. mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the map kinase pathway.
6718	regulatory light chain of myosin. does not bind calcium.
6719	plays a role as a receptor for the recognition of mhc class i hla-e molecules by nk cells and some cytotoxic t-cells.
6720	
6721	
6722	
6723	could be a melanogenic enzyme. could represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. release of the soluble form, me20-s, could protect tumor cells from antibody mediated immunity.
6724	
6725	
6726	probably important in the developing nervous system.
6727	stimulates specifically the gtpase activity of ypt6.
6728	
6729	
6730	
6731	stimulates the gtpase activity of tubulin, but does not enhance tubulin heterodimerization. acts as guanine nucleotide dissociation inhibitor for arl3.
6732	a positive regulator of the alternate pathway of complement. it binds to and stabilizes the c3- and c5-convertase enzyme complexes.
6733	
6734	
6735	
6736	
6737	
6738	binds unprenylated rab proteins, presents it to the catalytic rab ggtase dimer, and remains bound to it after the geranylgeranyl transfer reaction. the component a is thought to be regenerated by transferring its prenylated rab back to the donor membrane.
6739	
6740	involved in cytokinesis (potential).
6741	regulation of transcription.
6742	electroneutral exchange of protons for na(+) and k(+) across the mitochondrial inner membrane. contributes to organellar volume and calcium homeostasis.
6743	receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. stimulation by ltd4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. this response is mediated via a g-protein that activates a phosphatidylinositol-calcium second messenger system. the rank order of affinities for the leukotrienes is ltd4 >> lte4 = ltc4 >> ltb4.
6744	
6745	
6746	
6747	
6748	
6749	
6750	
6751	unknown.
6752	controls fundamental aspects of growth and development.
6753	
6754	
6755	tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (by similarity).
6756	removes 5-oxoproline from various penultimate amino acid residues except l-proline (by similarity).
6757	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
6758	
6759	exhibits lysophosphatidic acid acyltransferase activity (lpaat) (by similarity). may promote the activation of caspases and apoptosis.
6760	binds to activated (phosphorylated) protein-tyrosine kinases through its sh2 domain and regulates their kinase activity. during insulin stimulation, it also binds to irs-1.
6761	
6762	stimulates the transcription of various genes by recognizing and binding to a ccaat motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
6763	cleaves peptide substrates on the n-terminus of arginine residues in dibasic pairs.
6764	
6765	
6766	expressed by macrophages in acutely inflammated tissues and in chronic inflammations. seem to be an inhibitor of protein kinases. also expressed in epithelial cells constitutively or induced during dermatoses. may interact with components of the intermediate filaments in monocytes and epithelial cells.
6767	
6768	may be involved in transcriptional regulation.
6769	protein tyrosine phosphatase which stimulates progression from g1 into s phase during mitosis. promotes tumors. inhibits geranylgeranyl transferase type ii activity by blocking the association between rabggta and rabggtb.
6770	
6771	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i (by similarity).
6772	collagen type iv is specific for basement membranes.
6773	plays an important role in the eukaryotic peptide chain initiation process.
6774	this protein is an integral component of basement membranes. it is responsible for the fixed negative electrostatic charge and is involved in the charge-selective ultrafiltration properties. it serves as an attachment substrate for cells.
6775	
6776	probable zinc protease. may mediate cell-cell or cell- matrix interactions. isoform 2 displays alpha-secretase activity for app.
6777	
6778	binds to proliferating cell nuclear antigen. might affect pcna interaction with some cdk (cell division protein kinase) complexes; stimulates dna excision repair in vitro and inhibits entry of cells into s phase.
6779	required for normal golgi structure and for protein transport from the endoplasmic reticulum (er) through the golgi apparatus to the cell surface.
6780	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
6781	nuclear hormone receptor. involved in the retinoic acid response pathway. binds 9-cis retinoic acid (9c-ra).
6782	seems to play a role in junctional plaques.
6783	in contrast with other forms of fmo it does not seem to be a drug-metabolizing enzyme.
6784	5@#$%&->3@#$%& double-stranded dna exonuclease involved in mismatch repair and eventually also in mitotic recombination between direct repeats. also has a minor role in the correction of large dna mismatches that occur in the heteroduplex dna during meiotic recombination at the his4 locus.
6785	
6786	may function as an adapter protein or regulator of ras signaling pathways.
6787	
6788	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
6789	
6790	
6791	may play a functional role in the immune system, as well as in the nervous system. induces b-cells to aggregate and improves their viability in vitro.
6792	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
6793	may play a role in macrophage activation and function.
6794	
6795	
6796	seems to act as a transcriptional repressor.
6797	component of heterochromatin. recognizes and binds histone h3 tails methylated at lys-9, leading to epigenetic repression. can interact with lamin b receptor (lbr). this interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. involved in the formation of functional kinetochore through interaction with mis12 complex proteins.
6798	participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. mediates rac1-dependent reorganization of actin filaments. contributes to the activation of pld2 (by similarity).
6799	participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. mediates rac1-dependent reorganization of actin filaments. contributes to the activation of pld2 (by similarity).
6800	
6801	
6802	
6803	
6804	
6805	
6806	
6807	
6808	
6809	
6810	
6811	
6812	
6813	
6814	plays a role in the formation of functional neural circuits from the early stages of synapse formation. has a role in the development of cns functions involved in locomotor activity.
6815	transcription coregulator that can have both coactivator and corepressor functions. isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid x (rxrs) and thyroid hormone (trs) in a ligand-dependent fashion. in contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin d, progesterone receptor, glucocorticoid nor estrogen. acts as a transcriptional corepressor via its interaction with the nfkb1 nf-kappa-b subunit, possibly by interfering with the transactivation domain of nfkb1. induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. may also act as an inhibitor of cyclin a-associated kinase.
6816	may participate in the obstruction of fluid outflow in the trabecular meshwork.
6817	
6818	
6819	
6820	
6821	
6822	
6823	
6824	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
6825	component of a protein kinase signal transduction cascade. regulates the jnk and erk5 pathways by phosphorylating and activating map2k5 and map2k7. plays a role in caveolae kiss- and-run dynamics (by similarity).
6826	calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction.
6827	may be involved in transcriptional regulation.
6828	able to activate nf-kappa-b 1 by stimulating proteasome- mediated proteolysis of nf-kappa-b 1/p105. plays a role in the cell cycle. the longer form of cot has some transforming activity, although it is much weaker than the activated cot oncoprotein.
6829	
6830	
6831	
6832	
6833	
6834	catalyzes the formation of s-adenosylmethionine from methionine and atp.
6835	
6836	controls the genesis of the spleen. binds to the dna sequence 5@#$%&-ggcggtaagtgg-3@#$%&.
6837	
6838	may act as a molecular switch during maturation of the 40s ribosomal subunit in the nucleolus (by similarity).
6839	
6840	potent plasminogen activator and is clinically used for therapy of thrombolytic disorders.
6841	inhibitor of wnt signaling pathway.
6842	this is a receptor for the tachykinin neuropeptide substance k (neurokinin a). it is associated with g proteins that activate a phosphatidylinositol-calcium second messenger system.
6843	
6844	
6845	
6846	essential for the control of the cell cycle at the g2/m (mitosis) transition.
6847	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
6848	
6849	may have an important and specific function in tumor progression and embryogenesis. cleaves alpha-1-antitrypsin.
6850	may act as a gtpase activating protein for rab family protein(s).
6851	participates in the bidirectional intercellular signaling between the posterior follicle cells and oocyte to establish spatial coordinates that induces axis formation. complex with tsu is essential for cytoplasmic localization of oskar in the posterior pole of oocytes. required for the polarization of the oocyte microtubule cytoskeleton.
6852	
6853	
6854	
6855	catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (ipp) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (dmapp) (by similarity).
6856	receptor for the chemotactic and inflammatory peptide anaphylatoxin c3a. this receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
6857	
6858	
6859	may be involved in cell-cell interactions and recognition.
6860	
6861	receptor for glutamate. the activity of this receptor is mediated by a g-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current.
6862	
6863	
6864	
6865	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
6866	controls reversibly actin polymerization and depolymerization in a ph-sensitive manner. it has the ability to bind g- and f-actin in a 1:1 ratio of cofilin to actin. it is the major component of intranuclear and cytoplasmic actin rods.
6867	thiol protease which is believed to participate in intracellular degradation and turnover of proteins. has also been implicated in tumor invasion and metastasis.
6868	
6869	
6870	
6871	positive regulator of myogenesis. could play a role in mechanical stretch sensing.
6872	involved in the activation cascade of caspases responsible for apoptosis execution. cleaves caspase-1.
6873	plays a major role in ketone body metabolism.
6874	
6875	
6876	type i collagen is a member of group i collagen (fibrillar forming collagen).
6877	
6878	chaperone. isoform 2 may function as an endogenous inhibitory regulator of hsc70 by competing the cochaperones.
6879	
6880	
6881	
6882	
6883	may play a role in the regulation of sterol metabolism. binds a range of oxysterols.
6884	collagen type iii occurs in most soft connective tissues along with type i collagen.
6885	
6886	
6887	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
6888	mediates endoplasmic reticulum to golgi transport (by similarity).
6889	
6890	putative subunit of the beta-cell atp-sensitive potassium channel (katp). regulator of atp-sensitive k+ channels and insulin release.
6891	troponin i is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin atpase activity.
6892	
6893	pth elevates calcium level by dissolving the salts in bone and preventing their renal excretion.
6894	
6895	receptor for hyaluronic acid (ha). mediates cell-cell and cell-matrix interactions through its affinity for ha, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix matalloproteinases (mmps). adhesion with ha plays an important role in cell migration, tumor growth and progression. also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. altered expression or dysfunction causes numerous pathogenic phenotypes. great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
6896	
6897	
6898	receptor for atp and utp coupled to g-proteins that activate a phosphatidylinositol-calcium second messenger system. the affinity range is utp = atp > atp-gamma-s >> 2-methylthio-atp = adp.
6899	c1s b chain is a serine protease that combines with c1q and c1s to form c1, the first component of the classical pathway of the complement system. c1r activates c1s so that it can, in turn, activate c2 and c4.
6900	
6901	catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the c-terminus of several proteins having the c-terminal sequence cys-aliphatic-aliphatic-x. the alpha subunit is thought to participate in a stable complex with the substrate. the beta subunit binds the peptide substrate.
6902	
6903	
6904	
6905	
6906	probably involved in the control of the cell cycle.
6907	
6908	seems to be a intermediate filament associated protein that links endocytic vesicles to microtubules.
6909	
6910	
6911	
6912	
6913	
6914	may play a role in the assembly of ubiquitin ligase complexes and modulate the ubiquitination of target proteins. may be a transcription regulator (potential).
6915	
6916	
6917	
6918	
6919	dna primase is the polymerase that synthesizes small rna primers for the okazaki fragments made during discontinuous dna replication.
6920	
6921	catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. glucokinase has a high km for glucose, and so it is effective only when glucose is abundant. the role of gck is to provide g6p for the synthesis of glycogen. pancreatic glucokinase plays an important role in modulating insulin secretion. hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
6922	
6923	involved in sperm-egg adhesion. upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. the cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. this protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.
6924	plays a role in b-cell proliferation and differentiation. associates with cd5.
6925	
6926	
6927	
6928	
6929	acts on retinol bound on cellular retinol-binding protein (crbp).
6930	
6931	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
6932	calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. may be involved in transcriptional regulation. may be involved in regulation of microtubule dynamics. in vitro, phosphorylates creb1, crebbp, prm2, mef2a, mef2d and stmn1/op18. may be involved in spermatogenesis. may play a role in the consolidation/retention of hippocampus-dependent long-term memory (by similarity).
6933	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
6934	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
6935	
6936	
6937	histones h1 are necessary for the condensation of nucleosome chains into higher order structures.
6938	
6939	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
6940	
6941	inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the e1 alpha subunit, thus contributing to the regulation of glucose metabolism.
6942	stabilizer subunit of the dolichol-phosphate-mannose synthase complex.
6943	
6944	promotes angiogenesis and the proliferation of endothelial cells. able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
6945	pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
6946	
6947	may control phosphatidylinositol concentration in transport vesicles from the subrhabdomeric cisternae (src) to the rhabdomere. may function as a calcium transporter.
6948	actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia.
6949	
6950	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. this subunit is involved in antigen processing to generate class i binding peptides.
6951	
6952	protects the hemoglobin in erythrocytes from oxidative breakdown.
6953	is able to inhibit all four classes of proteinases by a unique @#$%&trapping@#$%& mechanism. this protein has a peptide stretch, called the @#$%&bait region@#$%& which contains specific cleavage sites for different proteinases. when a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. the entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
6954	
6955	controls sodium and chloride ion transport by inhibiting the activity of wnk4, potentially by either phosphorylating the kinase or via an interaction between wnk4 and the autoinhibitory domain of wnk1. wnk4 regulates the activity of the thiazide- sensitive na-cl cotransporter, slc12a3, by phosphorylation. wnk1 may also play a role in actin cytoskeletal reorganization.
6956	
6957	
6958	involved in maintaining the transcriptionally repressive state of genes. modifies chromatin, rendering it heritably changed in its expressibility (by similarity). regulator of cellular lifespan by maintaining the repression of cdkn2a, but not by inducing telomerase activity.
6959	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
6960	involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-lewis x determinant. has a alpha-2,3- sialyltransferase activity toward gal-beta1,4-glcnac structure on glycoproteins and glycolipids. has a restricted substrate specificity, it utilizes gal-beta1,4-glcnac on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-gm1.
6961	essential for the formation of dna replication focal centers; stably associates with foci elements generating binding sites for rp-a. exhibits a magnesium-dependent atp-dependent dna- helicase activity. may be involved in the control of genomic stability (by similarity).
6962	
6963	stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. active in the presence of nad as cofactor but not in the presence of nadp.
6964	transcriptional repressor.
6965	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
6966	
6967	
6968	
6969	
6970	sulfate transporter. may play a role in endochondral bone formation.
6971	transports l-glutamate and also l- and d-aspartate. essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. acts as a symport by cotransporting sodium.
6972	
6973	
6974	
6975	
6976	cytokine. inhibits inflammatory cytokine production. synergizes with il2 in regulating interferon-gamma synthesis. may be critical in regulating inflammatory and immune responses.
6977	
6978	
6979	
6980	the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-coa and co(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (e1), dihydrolipoamide acetyltransferase (e2) and lipoamide dehydrogenase (e3).
6981	component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix.
6982	may play a structural role at sites of cell adhesion in maintaining cell shape and motility. in addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. may be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
6983	
6984	
6985	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
6986	
6987	
6988	tubulin-folding protein; involved in the final step of the tubulin folding pathway.
6989	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii.
6990	
6991	plays a role in neurofilament network integrity. may be involved in modulating axonal architecture during development and in the adult. in vitro, increases the susceptibility of neurofilament-h to calcium-dependent proteases (by similarity). may also function in modulating the keratin network in skin. activates the mapk and elk-1 signal transduction pathway (by similarity).
6992	
6993	binds to and inhibits the transcriptional repressor zbtb33, which may lead to activation of target genes of the wnt signaling pathway (by similarity). may associate with and regulate the cell adhesion properties of both c- and e-cadherins. implicated both in cell transformation by src and in ligand- induced receptor signaling through the egf, pdgf, csf-1 and erbb2 receptors.
6994	
6995	participates in the wnt signaling pathway. implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb and the transcription factor jun. phosphorylates jun at sites proximal to its dna-binding domain, thereby reducing its affinity for dna.
6996	
6997	essential component of the scf (skp1-cul1-f-box protein) e3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. in the scf complex, serves as a rigid scaffold that organizes the skp1-f-box protein and rbx1 subunits. may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
6998	
6999	
7000	essential component of the scf (skp1-cul1-f-box protein) e3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. in the scf complex, serves as a rigid scaffold that organizes the skp1-f-box protein and rbx1 subunits. may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
7001	
7002	
7003	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
7004	
7005	collagen type iv is specific for basement membranes.
7006	c-terminal processed part of pcpe (ct-pcpe) may have an metalloproteinase inhibitory activity.
7007	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
7008	
7009	
7010	may function as a tumor suppressor, inhibiting colony formation, causing g1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
7011	
7012	stimulates specifically the gtpase activity of ypt6.
7013	
7014	catalyzes the o-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. also shortens the biological half-lives of certain neuroactive drugs, like l-dopa, alpha-methyl dopa and isoproterenol.
7015	
7016	stimulator of protein export for nes-containing proteins. also plays a role in the nuclear export of u1 snrna, trna, and mrna (by similarity).
7017	modulates the activity of rho-like proteins and connects extracellular signals to cytoskeletal activities. acts as a gdp- dissociation stimulator protein that stimulates the gdp-gtp exchange activity of rho-like gtpases and activates them. activates rac1, cdc42, and to a lesser extent rhoa (by similarity). affects invasiveness of t-lymphoma cells.
7018	
7019	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of calcium.
7020	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
7021	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
7022	converts specific uridines to psi in a number of trna substrates. acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing trna. involved in regulation of nuclear receptor activity possibly through pseudouridylation of sra1 rna (by similarity).
7023	may belong to a complex displaying n-terminal acetyltransferase activity (by similarity).
7024	
7025	
7026	could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by ngf. may be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (by similarity).
7027	receptor for neuropeptide y and peptide yy. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity. seems to be associated with food intake. could be involved in feeding disorders.
7028	neuronal cell surface protein that may be involved in cell recognition and cell adhesion. may mediate intracellular signaling.
7029	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
7030	collagen type iv is specific for basement membranes. vital for embryonic development.
7031	collagen type iv is specific for basement membranes. vital for embryonic development.
7032	
7033	probably plays a role in anchoring the complex to other cellular components.
7034	
7035	activates apoptosis and interacts selectively with survival-promoting proteins bcl-2 and bcl-x(l).
7036	
7037	transcriptional repressor.
7038	transcriptional repressor.
7039	involved in recruiting unphosphorylated forms of smad2/smad3 to the tgf-beta receptor by controlling their subcellular localization and by interacting and colocalizing with the tgf-beta receptor. phosphorylation of smad2/smad3 induces dissociation from zfyve9 and formation of smad2/smad4 complexes and nuclear translocation.
7040	
7041	
7042	transport of phosphate groups from the cytosol to the mitochondrial matrix. phosphate is cotransported with h(+).
7043	
7044	
7045	
7046	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
7047	activates pro-caspase-1 and pro-caspase-8. potentiates casp8-mediated apoptosis. activates nf-kappa-b.
7048	
7049	
7050	
7051	dna helicase that may play a role in the repair of dna that is damaged by ultraviolet light or other mutagens. exhibits a magnesium-dependent atp-dependent dna-helicase activity that unwinds single- and double-stranded dna in a 3@#$%&-5@#$%& direction.
7052	
7053	calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.
7054	integrin alpha-9/beta-1 is a receptor for vcam1, cytotactin and osteopontin. it recognizes the sequence a-e-i-d-g- i-e-l in cytotactin.
7055	
7056	this enzyme is required for electron transfer from nadp to cytochrome p450 in microsomes. it can also provide electron transfer to heme oxygenase and cytochrome b5. may function to clear the olfactory organ (antennae) from accumulating chemicals.
7057	the enzyme cleaves lys-arg and arg-ser bonds. it activates, in a reciprocal reaction, factor xii after its binding to a negatively charged surface. it also releases bradykinin from hmw kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
7058	binds to the gm-csf promoter. seems to act as a repressor. binds also to full length mrna and to short rna sequences containing the consensus site 5@#$%&-uccauca-3@#$%&. may have a role in translation repression (by similarity).
7059	
7060	histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). in addition, histatins exhibit antibacterial and antifungal activities.
7061	promotes the exchange of ras-bound gdp by gtp. functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development.
7062	mediates estrogen action in various target organs.
7063	id (inhibitor of dna binding) hlh proteins lack a basic dna-binding domain but are able to form heterodimers with other hlh proteins, thereby inhibiting dna binding.
7064	this is the smallest of the 5 chains of the enzymatic component (coupling factor cf(1)) of the mitochondrial atpase complex (by similarity).
7065	
7066	receptor with an affinity for galactose and fucose. could be involved in endocytosis.
7067	
7068	
7069	may modulate the functions ascribed to brca1 in transcriptional regulation, dna repair, and/or cell cycle checkpoint control.
7070	
7071	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1c gives rise to l-type calcium currents. long-lasting (l-type) calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group. they are blocked by dihydropyridines (dhp), phenylalkylamines, benzothiazepines, and by omega-agatoxin-iiia (omega-aga-iiia). they are however insensitive to omega-conotoxin- gvia (omega-ctx-gvia) and omega-agatoxin-iva (omega-aga-iva). calcium channels containing the alpha-1c subunit play an important role in excitation-contraction coupling in the heart. the various isoforms display marked differences in the sensitivity to dhp compounds.
7072	
7073	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
7074	this protein is a component of ribonucleosomes.
7075	receptor for arginine vasopressin. the activity of this receptor is mediated by g proteins which activate a phosphatidyl- inositol-calcium second messenger system. has been involved in social behaviors, including affiliation and attachment.
7076	
7077	this protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.
7078	during embryonic development, some isoforms are essential for proper neuronal differentiation and organization. required for cell polarity; maintenance of apicobasal polarity. plays a critical role at septate junctions in cellular growth control during larval development. the presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
7079	
7080	
7081	type i collagen is a member of group i collagen (fibrillar forming collagen).
7082	involved in late endocytic transport. contributes to the maturation of phagosomes (acidification) (by similarity).
7083	
7084	oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. targets to the golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.
7085	enzyme involved in the biosynthesis of the e-selectin ligand, sialyl-lewis x. catalyzes the transfer of fucose from gdp- beta-fucose to alpha-2,3 sialylated substrates.
7086	
7087	controls phosphatidylcholine synthesis.
7088	
7089	
7090	
7091	
7092	
7093	may be involved in transcriptional regulation.
7094	probable zinc endopeptidase.
7095	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
7096	
7097	insulin-regulated facilitative glucose transporter. binds cytochalasin b in a glucose-inhibitable manner. seems to be a dual-specific sugar transporter as it is inhibitable by fructose (by similarity).
7098	
7099	
7100	sterol sensor. necessary for the proteolytic activation of srebps by site-1 protease in the golgi.
7101	
7102	
7103	
7104	
7105	required for protein translocation and folding in the endoplasmic reticulum (er). functions as a nucleotide exchange factor for the er lumenal chaperone hspa5.
7106	
7107	not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. antigen recognized on a melanoma by autologous cytolytic t-lymphocytes.
7108	regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. the condensin complex probably introduces positive supercoils into relaxed dna in the presence of type i topoisomerases and converts nicked dna into positive knotted forms in the presence of type ii topoisomerases. may target the condensin complex to dna via its c-terminal domain.
7109	involved in ph regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. major proton extruding system driven by the inward sodium ion chemical gradient. plays an important role in signal transduction.
7110	adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. may regulate the formation of clathrin-coated vesicles. isoform 1 could be involved in brain-specific synaptic vesicle recycling.
7111	
7112	
7113	
7114	plays a central role as a glucosyl donor in cellular metabolic pathways.
7115	may play a role at early stages of development of specific neural lineages in most regions of the cns, and of several lineages in the pns. essential for the generation of olfactory and autonomic neurons. activates transcription by binding to the e box (5@#$%&-canntg-3@#$%&).
7116	
7117	
7118	
7119	this is a receptor for interleukin-3.
7120	may act as a specific coactivator for the mammalian tefs.
7121	
7122	may function as a gtpase-activating protein and may play important roles during t-cell activation.
7123	
7124	protein kinase that act on both serine and threonine residues.
7125	
7126	promotes the exchange of cdc42-bound gdp by gtp. controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. cdc24 may be involved in the initial selection and organization of the budding site.
7127	
7128	may act as a gtpase activating protein for rab family protein(s).
7129	binds to actin and affects the structure of the cytoskeleton. at high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. by binding to pip2, it inhibits the formation of ip3 and dg.
7130	orphan receptor.
7131	nociceptin is the ligand of the opioid receptor-like receptor (oprl1). it may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. may be involved in neuronal differentiation and development (by similarity).
7132	putative transcription factor involved in pancreas development and function.
7133	
7134	
7135	
7136	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to the dna sequence 5@#$%&-aa[at]ttttattac-3@#$%&.
7137	probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. may act by preventing binding of positively-activing ccaat factors to promoters. plays an essential role in lung maturation (by similarity).
7138	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
7139	
7140	
7141	possible cell adhesion receptor. it possesses an intrinsic protein tyrosine phosphatase activity (ptpase). it controls motor axon guidance.
7142	this protein is associated with nerve growth. it is a major component of the motile @#$%!growth cones@#$%! that form the tips of elongating axons.
7143	high-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. may also function as an ecotropic retroviral leukemia receptor.
7144	
7145	shows activity also towards tryptophan, aspartate and hydroxykinurenine.
7146	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)- pregnene-3,20-dione, precursors to testosterone and progesterone, respectively.
7147	background potassium channel. rectification is dependent on external potassium concentration. acts as an outwardly rectifying channel but as external potassium levels increase, this is reversed.
7148	minus-end directed microtubule motor. probable kinetochore motor. accumulates just before mitosis at the g2 phase of the cell cycle. probably important for chromosome movement and/or spindle elongation.
7149	receptor for atrial natriuretic peptide. does not have guanylate cyclase activity.
7150	receptor for atp that acts as a ligand gated ion channel. responsible for atp-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. could function in both fast synaptic transmission and the atp-mediated lysis of antigen-presenting cells.
7151	
7152	
7153	
7154	
7155	
7156	activity is required for interleukin 6 (il-6) induced differentiation. may play a role in the growth and differentiation of hematopoietic cells. may be involved in signal transduction in endocardial and arterial endothelial cells.
7157	
7158	
7159	
7160	
7161	
7162	may play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.
7163	promote mitochondrial fission (by similarity).
7164	
7165	
7166	binds to bacterial lipopolysaccharides (lps), has antibacterial activity.
7167	dna-binding protein that specifically binds heat shock promoter elements (hse) and activates transcription. in higher eukaryotes, hsf is unable to bind to the hse unless the cells are heat shocked.
7168	
7169	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
7170	may be involved in transcriptional regulation.
7171	
7172	
7173	
7174	receptor for ecdysone. binds to ecdysone response elements (ecres).
7175	
7176	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to sites in the 5@#$%&-flanking sequence of its coding region with various affinities. the consensus sequences of the high and low affinity binding sites are 5@#$%&-taatga[cg]-3@#$%& and 5@#$%&-ctaatttt- 3@#$%&.
7177	may be involved in transcriptional regulation.
7178	
7179	
7180	the kinesin family may recognize, transport and position their specific cargos in a single type of neuronal cell.
7181	
7182	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
7183	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex.
7184	
7185	potential transcription factor. may mediate some of the neuroprotective peptide vip-associated effects involving normal growth and cancer proliferation.
7186	
7187	
7188	could be involved in oogenesis. involved in the regulation of endosome dynamics. implicated in a novel signal transduction pathway, in which isoform 3 and csk are sequentially activated by rhod to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
7189	unknown. may be involved in differentiation of metanephric precursor cells.
7190	
7191	
7192	
7193	
7194	essential subunit of n-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an asn-x-ser/thr consensus motif in nascent polypeptide chains.
7195	
7196	
7197	
7198	
7199	
7200	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
7201	
7202	
7203	
7204	
7205	
7206	type iv collagen is the major structural component of glomerular basement membranes (gbm), forming a @#$%&chicken-wire@#$%& meshwork together with laminins, proteoglycans and entactin/nidogen.
7207	
7208	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
7209	
7210	component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix.
7211	muscle contraction.
7212	cell autonomous negative regulator of lin-12/notch- mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. may function as part of an e3 complex to target the intracellular domains of lin-12/notch proteins for ubiquitin-dependent degradation.
7213	stimulates chloride conductance when expressed in cells. mediates chloride ion transport across the membrane. it may be a component or a regulator of the chloride channel. it may participate in cellular growth control.
7214	glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. may play an important role in intestinal mucosal growth in the early period of life.
7215	involved in axon growth. plays an essential role in neurite extension of cerebellar granule cells.
7216	probable transcription regulator.
7217	may have a function in the nucleus.
7218	
7219	destroys radicals which are normally produced within the cells and which are toxic to biological systems.
7220	plays a role in lipoprotein assembly and dietary cholesterol absorption. in addition to its acyltransferase activity, it may act as a ligase. may provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
7221	this is a carcinoma-associated protein, probably a mucin.
7222	
7223	essential for cell viability. taf9 and taf9l are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. may have a role in gene regulation associated with apoptosis. tafs are components of the transcription factor iid (tfiid) complex, the tbp-free tafii complex (tftc), the pcaf histone acetylase complex and the staga transcription coactivator-hat complex. tfiid or tftc are essential for the regulation of rna polymerase ii-mediated transcription (by similarity).
7224	
7225	plc-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
7226	may function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.
7227	
7228	
7229	essental for release from glucose repression. it interacts and has functional relationship to the regulatory protein snf4. interacts also with sip1, sip2 and gal83. could phosphorylates cat8.
7230	
7231	adhesion plaque protein. binds alpha-actinin and the crp protein. may be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (by similarity).
7232	transports betaine and gaba. may have a role in regulation of gabaergic transmission in the brain through the reuptake of gaba into presynaptic terminals, as well as in osmotic regulation.
7233	galectin that binds lactose and a related range of sugars. may be involved in the assembly of adherens junctions.
7234	neuronal cell surface protein that may be involved in cell recognition and cell adhesion. may mediate intracellular signaling.
7235	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. displays glutathione peroxidase activity with cumene hydroperoxide.
7236	
7237	
7238	
7239	thought to form a receptor-activated non-selective calcium permeant cation channel. probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or g-protein coupled receptors. has also been shown to be calcium-selective (by similarity). may also be activated by intracellular calcium store depletion.
7240	
7241	
7242	
7243	
7244	
7245	
7246	
7247	
7248	
7249	not known, could be a tyrosine-phosphatase.
7250	
7251	
7252	efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. the bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates.
7253	
7254	
7255	interacts with the internal control region (icr) of approximately 50 bases within the 5s rna genes, is required for correct transcription of these genes by rna polymerase iii. also binds the transcribed 5s rna@#$%&s. may initiate transcription of the 5s ribosomal rna gene and maintain the stability of transcription of other genes.
7256	
7257	
7258	involved in dna excision repair. may play a part in dna damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes.
7259	
7260	involved in active uptake of glycerol driven by electrogenic proton symport.
7261	
7262	
7263	
7264	amidohydrolase that hydrolyzes specifically one of the carboamide linkages in d-pantetheine thus recycling pantothenic acid (vitamin b5) and releasing cysteamine.
7265	
7266	
7267	
7268	binds to the consensus sequence 5@#$%&-aacaaag-3@#$%& and is able to trans-activate transcription via this site (by similarity).
7269	hydrolyzes cerebroside sulfate.
7270	inhibitory regulator of the ras-cyclic amp pathway. stimulates the gtpase of normal but not oncogenic ras p21 (by similarity).
7271	
7272	
7273	
7274	this protein may be involved in b-cell activation. may also be involved in signal transduction and gene regulation.
7275	catalyzes the synthesis of dihydrouridine, a modified base found in the d-loop of most trnas. modifies yeast pre- trna(phe) in vitro at u17.
7276	may be an organic anion pump relevant to cellular detoxification.
7277	involved in gpi-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of gpi (by similarity).
7278	
7279	
7280	
7281	
7282	receptor for the cytotoxic ligand tnfsf10/trail. the adapter molecule fadd recruits caspase-8 to the activated receptor. the resulting death-inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. promotes the activation of nf- kappa-b.
7283	orphan receptor. probable mediator of ebv effects on b lymphocytes or of normal lymphocyte functions.
7284	
7285	may act as scaffold protein.
7286	may be involved in actively transporting phosphate into cells via na(+) cotransport (by similarity).
7287	
7288	the elongation of primed dna templates by dna polymerase delta and epsilon requires the action of the accessory proteins pcna and activator 1. subunit 1 is essential for cell cycle progression. it may associate with components of the dna replication machinery and serve to enhance the efficiency of dna replication.
7289	adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates.
7290	may be involved in transcriptional regulation.
7291	efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an atp-dependent reaction. involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination. the lig4-xrcc4 complex is responsible for the nhej ligation step, and xrcc4 enhances the joining activity of lig4. binding of the lig4-xrcc4 complex to dna ends is dependent on the assembly of the dna- dependent protein kinase complex dna-pk to these dna ends.
7292	
7293	
7294	
7295	
7296	bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (fgf) but inhibits the growth of cultured vascular endothelial cells. may contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development.
7297	part of the dynein complex of respiratory cilia.
7298	calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). it can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.
7299	
7300	
7301	orphan receptor. ligands are likely small molecules, either sharing some similarities with trace amine as, e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of phenylethylamines (such as phenylethanolamine) or being any kind of metabolite of amino acids or biogenic amine neurotransmitters.
7302	
7303	
7304	this protein promotes the gtp-dependent binding of aminoacyl-trna to the a-site of ribosomes during protein biosynthesis.
7305	attaches integral membrane proteins to cytoskeletal elements. also binds to cytoskeletal proteins. required for coordinate assembly of na/ca exchanger, na/k atpase and insp3 receptor at sarcoplasmic reticulum sites in cardiomyocytes.
7306	
7307	
7308	
7309	may be essential for the correct composition of cartilage and bone matrix during development. has no activity toward steroid sulfates.
7310	may act as a transcription factor that could act on to regulate one of the phases of hair growth.
7311	
7312	
7313	
7314	
7315	
7316	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
7317	may act as scaffold protein.
7318	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
7319	
7320	
7321	
7322	receptor for macrophage stimulating protein (msp). has a tyrosine-protein kinase activity.
7323	integrin alpha-1/beta-1 is a receptor for laminin and collagen. it recognizes the proline-hydroxylated sequence g-f-p-g- e-r in collagen.
7324	
7325	plasma membrane t-snare that mediates docking of transport vesicles. necessary for the translocation of slc2a4 from intracellular vesicles to the plasma membrane. may also play a role in docking of synaptic vesicles at presynaptic active zones.
7326	
7327	transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. involved in particular in lens epithelial cell gene regulation and stress responses. may play an important role in lens epithelial to fiber cell terminal differentiation. may play a protective role during stress-induced apoptosis. isoform 2 is a more general and stronger transcriptional coactivator. isoform 2 may also act as an adapter to coordinate pre-mrna splicing. cellular cofactor for lentiviral integration.
7328	necessary for efficient rna polymerase ii transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by s-ii allows the resumption of elongation from the new 3@#$%&terminus.
7329	may play a role in cell differentiation in the intestinal epithelium.
7330	may play an important role in the control of the immune response and during pregnancy (by similarity).
7331	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
7332	
7333	
7334	required for dna recombination, repair and replication. the activity of rp-a is mediated by single-stranded dna binding and protein interactions.
7335	npy is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
7336	may be involved in diverse cell survival mechanisms.
7337	
7338	inter-alpha-trypsin inhibitor, present in plasma and urine, inhibits trypsin, plasmin, and lysosomal granulocytic elastase.
7339	may be involved in transcriptional regulation.
7340	
7341	
7342	
7343	may be involved in transcriptional regulation.
7344	belongs to an adhesion system, probably together with the e-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (ajs). nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
7345	
7346	
7347	
7348	
7349	receptor for the hormone galanin.
7350	could promote homologous recombination at sites of dna damage. rrp1 has apurinic endonuclease and double-stranded dna 3@#$%& exonuclease, activities and carries out single-stranded dna renaturation in a mg(2+)-dependent manner.
7351	may be involved in the nuclear localization pathway of mcm3.
7352	
7353	
7354	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
7355	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel. rho-1 gaba receptor could play a role in retinal neurotransmission.
7356	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
7357	
7358	mediates cellular binding of particles and immune complexes that have activated complement.
7359	
7360	v-snare that mediates vesicle transport pathways through interactions with t-snares on the target membrane. these interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.
7361	
7362	
7363	
7364	
7365	
7366	
7367	transcription repressor capable of inhibiting the transactivation capability of tcf3/e47. may play a role in regulating antigen-dependent b-cell differentiation.
7368	interacts with guanosine triphosphate (gtp)-bound forms of rab6a and rab6b. may act as a motor required for the retrograde rab6 regulated transport of golgi membranes and associated vesicles along microtubles. has a microtubule plus end-directed motility (by similarity).
7369	
7370	
7371	its physiological role is not yet clear.
7372	likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. capable of cleavage at the rx(k/r)r consensus motif.
7373	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to g-alpha subfamily 1 members, with the order g(i)a3 > g(i)a1 > g(o)a >> g(z)a/g(i)a2. activity on g(z)-alpha is inhibited by phosphorylation and palmitoylation of the g-protein.
7374	could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. has guanine nucleotide-binding activity but undetectable intrinsic gtpase activity.
7375	
7376	
7377	
7378	may serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
7379	involved in mediating u snrna export from the nucleus. binds to 5@#$%& capped mrna.
7380	
7381	
7382	component of the peroxisomal translocation machinery with pex14 and pex17. functions as a docking factor for the predominantly cytoplasmic pts1 receptor (pas10/pex5). involved in the import of pts1 and pts2 proteins.
7383	iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones t(3) and t(4).
7384	the glycine cleavage system catalyzes the degradation of glycine.
7385	
7386	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
7387	inhibits human amidolytic and kininogenase activities of tissue kallikrein. inhibition is achieved by formation of an equimolar, heat- and sds-stable complex between the inhibitor and the enzyme, and generation of a small c-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.
7388	
7389	
7390	
7391	specifically phosphorylates the activated forms of g protein-coupled receptors.
7392	may have a role in promoting cell migration (motogen).
7393	
7394	
7395	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
7396	may be a transcription factor involved in regulating the expression of genes active in the s phase during cell cycle progression in t-cells. may be involved in tumor progression (by similarity). represses ela2 transcription.
7397	
7398	the glycine receptor is a neurotransmitter-gated ion channel. binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
7399	this enzyme is required for electron transfer from nadp to cytochrome p450 in microsomes. it can also provide electron transfer to heme oxygenase and cytochrome b5. may function to clear the olfactory organ (antennae) from accumulating chemicals.
7400	clathrin is the major protein of the polyhedral coat of coated pits and vesicles. two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-golgi network.
7401	involved in protein n-glycosylation. essential for the second step of the dolichol-linked oligosaccharide pathway.
7402	
7403	bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. catalyzes the formation of 3- ketoacyl-coa intermediates from both straight-chain and 2-methyl- branched-chain fatty acids (by similarity).
7404	
7405	derived from proteolytic degradation of complement c4, c4a anaphylatoxin is a mediator of local inflammatory process. it induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
7406	
7407	
7408	involved in the presentation of foreign antigens to the immune system.
7409	may play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of tgf-beta1 through interaction with retinoblastoma and the subsequent displacement of e2f-1.
7410	involved in directing the movement of organelles along actin filaments (by similarity).
7411	
7412	
7413	
7414	
7415	
7416	
7417	may convert the inactive conformation of integrin alpha- iib/beta3 to an active form through the binding to the integrin cytoplasmic domain.
7418	intracellular transport of retinol.
7419	
7420	
7421	
7422	catalyzes c14-demethylation of lanosterol; it transforms lanosterol into 4,4@#$%&-dimethyl cholesta-8,14,24-triene-3-beta-ol.
7423	
7424	arm and abl proteins function cooperatively at adherens junctions in both the cns and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone@#$%&s response to midline cues. the ability of pcc/mp2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both slit/robo and abl-dependent signaling pathways.
7425	
7426	
7427	
7428	converts big endothelin-1 to endothelin-1 (by similarity).
7429	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
7430	
7431	
7432	molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
7433	c9 is the final component of the complement system to be added in the assembly of the membrane attack complex. it is able to enter lipid bilayers, forming transmembrane channels.
7434	
7435	phosphorylates microtubule-associated protein 2 (map2). myelin basic protein (mbp), and elk-1; may promote entry in the cell cycle.
7436	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
7437	interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite dna, called the cenp-b box. may organize arrays of centromere satellite dna into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.
7438	may deubiquitinate one or more critical proteins that are involved in the condensation of mitotic chromosomes, possibly acting selectively on histones h2a and h2b, the major ubiquitinated proteins of chromatin. it is able to deubiquitinate histone h2a in vitro, the phosphorylated form of the protein is also enzymatically active.
7439	
7440	
7441	links covalently the heme group to the apoprotein of cytochrome c (by similarity).
7442	
7443	
7444	works in concert with the 5alpha/5beta-steroid reductases to convert steroid hormones into the 3alpha/5alpha and 3alpha/5beta-tetrahydrosteroids. catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5alpha-dht) to 5-alpha-androstane-3alpha,17beta-diol (3-alpha-diol).
7445	protease that catalyzes two essential functions in the sumo pathway: processing of full-length smt3 to its mature form and deconjugation of smt3 from targeted proteins. has an essential role in the g2/m phase of the cell cycle.
7446	has dna hydrolytic activity. does not bind to actin. cleaves chromatin dna to nucleosomal units.
7447	
7448	
7449	histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a central role in histone code. preferentially demethylates mono- and dimethylated h3 lys-9 residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated h3 lys-9. demethylation of lys residue generates formaldehyde and succinate. involved in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes, resulting in h3 lys-9 demethylation and transcriptional activation.
7450	
7451	
7452	
7453	converts lysophosphatidic acid (lpa) into phosphatidic acid by incorporating acyl moiety at the 2 position.
7454	
7455	
7456	
7457	binds to all human somatostatin receptor (sstr) subtypes. it also inhibits camp production induced by forskolin through sstrs.
7458	catalyzes the nadph-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
7459	probable oxidoreductase that acts as a caspase- independent mitochondrial effector of apoptotic cell death. extramitochondrial aif induces nuclear chromatin condensation and large scale dna fragmentation (in vitro).
7460	
7461	acts as a multispecific organic anion pump which can transport nucleotide analogs.
7462	plays a role in dna repair by forming with ddb2 the uv- damaged dna-binding protein complex (uv-ddb). component of the rbx1-cul4-ddb2 ubiquitin ligase.
7463	may be involved in cell growth. probably acts as a terminal oxidase of plasma electron transport from cytosolic nad(p)h via hydroquinones to acceptors at the cell surface. hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. the activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
7464	
7465	
7466	
7467	
7468	iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones t(3) and t(4).
7469	collagen type iii occurs in most soft connective tissues along with type i collagen.
7470	
7471	
7472	catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the c-terminus of several proteins. the beta subunit is responsible for peptide-binding.
7473	
7474	
7475	
7476	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. signaling by wnt-7a allows sexually dimorphic development of the mullerian ducts (by similarity).
7477	kinesin that supports microtubule movement in an atp- dependent manner and has a minus-end directed polarity. plays a crucial role in spindle morphogenesis in male arabidopsis meiosis. in atk1 mutants, male meiosis is defective, producing an abnormal number of microspores of variable sizes.
7478	
7479	
7480	
7481	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
7482	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules.
7483	receptor for msh (alpha, beta and gamma) and acth. this receptor is mediated by g proteins which activate adenylate cyclase.
7484	phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin i. the alpha chain may bind calmodulin.
7485	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
7486	
7487	
7488	catalyzes the conversion of 3@#$%&-phosphate to a 2@#$%&,3@#$%&- cyclic phosphodiester at the end of rna. the mechanism of action of the enzyme occurs in 3 steps: (a) adenylation of the enzyme by atp; (b) the enzyme acts on rna-n3@#$%&p to produce rna-n3@#$%&pp5@#$%&a; (c) a non catalytic nucleophilic attack by the adjacent 2@#$%&hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. the biological role of this enzyme is unknown but it is likely to function in some aspects of cellular rna processing.
7489	plays an important role in the physiology of adrenergic neurons.
7490	protein phosphatase (pp1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. involved in regulation of ionic conductances and long-term synaptic plasticity.
7491	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
7492	transcription activator for a number of liver genes such as afp, albumin, tyrosine aminotransferase, pepck, etc. interacts with the cis-acting regulatory regions of these genes.
7493	
7494	binds dna with high affinity. may also be involved in protein-protein interactions (by similarity).
7495	
7496	
7497	
7498	
7499	
7500	
7501	
7502	may be involved in several stages of intracellular trafficking (by similarity).
7503	major component of the vertebrate myofibrillar m band. binds myosin, titin, and light meromyosin. this binding is dose dependent.
7504	may be involved in transcriptional regulation.
7505	acts as a co-chaperone with an hsp70 protein (by similarity).
7506	
7507	probably involved in maintaining golgi structure.
7508	probably involved in maintaining golgi structure.
7509	contributes to invasiveness in malignant prostate cancer.
7510	
7511	deubiquitinating enzyme which may be involved in brca1 signal transduction pathway.
7512	melanocyte differentiation antigen. may transport substances required for melanin biosynthesis (by similarity).
7513	may be involved in several stages of intracellular trafficking (by similarity).
7514	bifunctional growth-modulating glycoprotein. inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells.
7515	
7516	may be involved in transcriptional regulation.
7517	
7518	
7519	
7520	nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. coactivates expression in an agonist- and af2-dependent manner. involved in the coactivation of different nuclear receptors, such as for steroids (gr and ers), retinoids (rars and rxrs), thyroid hormone (trs), vitamin d3 (vdr) and prostanoids (ppars). probably functions as a general coactivator, rather than just a nuclear receptor coactivator. may also be involved in the coactivation of the nf-kappa-b pathway. may coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
7521	may play a role in host defense against tumors and pathogens. binds z-dna (by similarity).
7522	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
7523	trap proteins are part of a complex whose function is to bind calcium to the er membrane and thereby regulate the retention of er resident proteins.
7524	chloride channel or a regulator or accessory subunit of other proteins that could provide the pore-froming function.
7525	
7526	
7527	
7528	
7529	important negative regulator in hematopoiesis and immune systems; may be involved in ending inflammatory responses through its inhibitory functions. inhibits endothelial nf-kappa-b signaling through a camp-dependent pathway. inhibits tnf-alpha- induced expression of endothelial adhesion molecules. involved in the control of fat metabolism and insulin sensitivity.
7530	
7531	involved in peroxisome biosynthesis and integrity. assembles membrane vesicles before the matrix proteins are translocated. as a docking factor for pex19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
7532	
7533	required maternally for proper expression of other homeotic genes involved in pattern formation, such as ubx.
7534	type i collagen is a member of group i collagen (fibrillar forming collagen).
7535	cleaves a-5@#$%&-ppp-5@#$%&a to yield amp and adp. possible tumor suppressor for specific tissues.
7536	
7537	
7538	required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
7539	removes residual c-terminal arg or lys remaining after initial endoprotease cleavage during prohormone processing. processes proinsulin.
7540	
7541	
7542	transcriptional repressor. binds with max to form a sequence-specific dna-binding protein complex which recognizes the core sequence cac[ga]tg. antagonizes myc transcriptional activity by competing for max (by similarity).
7543	
7544	
7545	
7546	involved in the association of mhc class i with transporter associated with antigen processing (tap) and in the assembly of mhc class i with peptide (peptide loading).
7547	phosphorylates proteins on serine, threonine, and tyrosine. probably associated with cell proliferation.
7548	major role in the synthesis of nucleoside triphosphates other than atp. the atp gamma phosphate is transferred to the ndp beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
7549	
7550	
7551	hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
7552	may be involved in the regulation of gene transcription and chromatin structure.
7553	may be involved in transcriptional regulation.
7554	
7555	
7556	
7557	binds to dna at special at-rich sequences at nuclear matrix- or scaffold-associated regions. thought to recognize the sugar-phosphate structure of double-stranded dna.
7558	
7559	
7560	
7561	
7562	
7563	
7564	
7565	
7566	
7567	
7568	has a strict specificity for hydrolysis of asparaginyl bonds. can also cleave aspartyl bonds slowly, especially under acidic conditions. may be involved in the processing of proteins for mhc class ii antigen presentation in the lysosomal/endosomal system.
7569	
7570	molecular chaperone that functions in the processing and transport of secreted proteins (by similarity).
7571	essential component of the cop9 signalosome complex (csn), a complex involved in various cellular and developmental processes. the csn complex is an essential regulator of the ubiquitin (ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of scf-type e3 ligase complexes, leading to decrease the ubl ligase activity of scf-type complexes such as scf, csa or ddb2. the complex is also involved in phosphorylation of p53/tp53, c-jun/jun, ikappabalpha/nfkbia, itpk1 and irf8/icsbp, possibly via its association with ck2 and pkd kinases. csn- dependent phosphorylation of tp53 and jun promotes and protects degradation by the ubl system, respectively. involved in early stage of neuronal differentiation via its interaction with nif3l1.
7572	
7573	
7574	
7575	
7576	
7577	
7578	
7579	
7580	
7581	modulator of adipocyte lipid metabolism, it coats lipid storage droplets to protect them to be broken down by hormone- sensitive lipase (hsl). its absence may result in leanness.
7582	mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. the receptor recognizes terminal galactose and n-acetylgalactosamine units. after ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. the receptor then returns to the cell membrane surface.
7583	
7584	component of the e3 ubiquitin ligase dcx det1-cop1 complex, which is required for ubiquitination and subsequent degradation of target proteins. the complex is involved in jun ubiquitination and degradation.
7585	
7586	
7587	chaperone protein involved in the assembly of the mitochondrial nadh:ubiquinone oxidoreductase complex (complex i) (by similarity).
7588	
7589	
7590	may be involved in transcriptional regulation.
7591	chemotactic factor for t-lymphocytes but not monocytes or granulocytes. may play a role in t-cell development in thymus and in trafficking and activation of mature t-cells. binds to ccr4.
7592	overproduction suppresses the slow growth phenotype of cpr7 mutant cells.
7593	
7594	
7595	
7596	
7597	
7598	may have a function in cell cycle regulation. binds to and may be involved in the transforming capacity of the adenovirus e1a protein. may act as a tumor suppressor. potent inhibitor of e2f-mediated trans-activation, associates preferentially with e2f5. binds to cyclins a and e.
7599	may function in membrane trafficking. exhibits calcium- dependent phospholipid binding properties (by similarity).
7600	
7601	
7602	
7603	
7604	may be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors (by similarity).
7605	binds to the n-terminal pts2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.
7606	
7607	forms a water-specific channel; mercury-sensitive. not permeable to glycerol or urea.
7608	
7609	type i collagen is a member of group i collagen (fibrillar forming collagen).
7610	
7611	may serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
7612	
7613	promotes caspase-mediated apoptosis. this proapoptotic activity is mediated predominantly through the activation of caspase 9. may be a component of the inflammasome, a protein complex which also includes nalp2, card8 and casp1 and whose function would be the activation of proinflammatory caspases (by similarity).
7614	
7615	
7616	
7617	
7618	mediates estrogen action in various target organs.
7619	
7620	
7621	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
7622	
7623	
7624	
7625	acts as a regulatory subunit of the 26 proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
7626	not known. may be involved in the synthesis of the sugar donor dol-p-man which is required in the synthesis of n-linked and o-linked oligosaccharides and for that of gpi anchors (by similarity).
7627	mediates the binding and degradation of acetylated low density lipoprotein (ac-ldl). mediates heterophilic interactions, suggesting a function as adhesion protein (by similarity).
7628	
7629	may play a role in mediating the heat shock response of some hsp70 genes. it is required for optimal growth of yeast cells at both low and high temperature.
7630	
7631	plays an important role in the normal skeletal development. may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
7632	
7633	muscle contraction.
7634	can degrade casein. could play a role in tissues homeostasis and repair.
7635	
7636	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation by repressing transcription of myocyte enhancer mef2c. during muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.
7637	
7638	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation by repressing transcription of myocyte enhancer mef2c. during muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.
7639	
7640	favors the reduction of estrogens and androgens. also has 20-alpha-hsd activity. uses preferentially nadh.
7641	
7642	chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. signals through ccr2b and ccr3 receptors. plays a role in the accumulation of leukocytes at both sides of allergic and nonallergic inflammation. may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. may play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
7643	promotes attachment of chondrocytes, fibroblasts, and osteoblasts. this binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). may play an important role in the regulation of chondrocyte growth and proliferation (by similarity).
7644	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
7645	may function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism.
7646	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
7647	
7648	
7649	
7650	
7651	
7652	may play a role in intracellular transport of gaba(a) receptors and its interaction with the cytoskeleton (by similarity).
7653	binds to actin and affects the structure of the cytoskeleton. at high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. by binding to pip2, it inhibits the formation of ip3 and dg.
7654	
7655	
7656	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
7657	
7658	endonuclease that specifically degrades the rna of rna- dna hybrids.
7659	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
7660	required for protein transport from the er to the golgi complex.
7661	
7662	
7663	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
7664	
7665	
7666	
7667	
7668	
7669	
7670	
7671	
7672	collagen type iv is specific for basement membranes. vital for embryonic development.
7673	
7674	
7675	transcription factor that binds to the immunoglobulin enchancer mu-e5/ke5-motif. binds to the e-box present in the somatostatin receptor 2 initiator element (sstr2-inr) to activate transcription (by similarity). preferentially binds to either 5@#$%&- acanntgt-3@#$%& or 5@#$%&-ccanntgg-3@#$%&.
7676	common mediator of signal transduction by tgf-beta (transforming growth factor) superfamily; smad4 is the common smad (co-smad). promotes binding of the smad2/smad4/fast-1 complex to dna and provides an activation function required for smad1 or smad2 to stimulate transcription. may act as a tumor suppressor.
7677	specialized low-affinity urea transporter. mediates urea transport in kidney.
7678	catalyzes the reduction of 3-ketodihydrosphingosine (kds) to dihydrosphingosine (dhs).
7679	
7680	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
7681	may be involved in transcriptional regulation.
7682	may be involved in transcriptional regulation.
7683	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
7684	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
7685	
7686	this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of sodium and potassium ions across the plasma membrane. this action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
7687	
7688	receptor for extracellular adenine nucleotides such as atp and adp. in platelets binding to adp leads to mobilization of intracellular calcium ions via activation of phospholipase c, a change in platelet shape, and probably to platelet aggregation.
7689	
7690	molecular calcium binding chaperone promoting folding, oligomeric assembly and quality control in the er via the calreticulin/calnexin cycle. this lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the er. interacts with the dna-binding domain of nr3c1 and mediates its nuclear export.
7691	
7692	could be involved in cell-cell interactions.
7693	
7694	
7695	
7696	
7697	necessary for the catabolism of n-linked carbohydrates released during glycoprotein turnover. cleaves all known types of alpha-mannosidic linkages.
7698	anion-transporting atpase. catalyzes the extrusion of arsenite.
7699	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
7700	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
7701	may be involved in transcriptional regulation.
7702	
7703	sequence specific transcriptional activator which binds to the pu-box, a purine-rich dna sequence (5@#$%&-gaggaa-3@#$%&) that can act as a lymphoid-specific enhancer. promotes development of plasmacytoid dendritic cells (pdcs), also known as type 2 dc precursors (pre-dc2) or natural interferon (ifn)-producing cells. these cells have the capacity to produce large amounts of interferon and block viral replication. may be required for b-cell receptor (bcr) signaling, which is necessary for normal b-cell development and antigenic stimulation.
7704	mediates interferon-stimulated response element (isre) promoter activation. functions as a molecular switch for antiviral activity. dsrna generated during the course of an viral infection leads to irf3 phosphorylation on the c-terminal serine/threonine cluster. this induces a conformational change, leading to its dimerization, nuclear localization and association with creb binding protein (crebbp) to form dsrna-activated factor 1 (draf1), a complex which activates the transcription of genes under the control of isre. the complex binds to the ie and prdiii regions on the ifn-alpha and ifn-beta promoters respectively. irf-3 does not have any transcription activation domains.
7705	
7706	
7707	inhibits nf-kappa-b activation. may participate in a regulatory mechanism that coordinates cellular responses controlled by nf-kappa-b transcription factor. may be a component of the inflammasome, a protein complex which also includes pycard, nalp2 and casp1 and whose function would be the activation of proinflammatory caspases.
7708	
7709	may control regulatory pathways relevant to schizophrenia and to psychotic illness. may play a role in late central nervous system development by modulating epo expression in response to cellular oxygen level (by similarity).
7710	
7711	
7712	
7713	
7714	inhibitor of hgf activator. also inhibits plasmin, plasma and tissue kallikrein, and factor xia.
7715	may be involved in transcriptional regulation.
7716	
7717	may be involved in transcriptional regulation.
7718	component of the drb sensitivity-inducing factor complex (dsif complex), which regulates mrna processing and transcription elongation by rna polymerase ii. dsif positively regulates mrna capping by stimulating the mrna guanylyltransferase activity of rngtt/cap1a. dsif also acts cooperatively with the negative elongation factor complex (nelf complex) to enhance transcriptional pausing at sites proximal to the promoter. transcriptional pausing may facilitate the assembly of an elongation competent rna polymerase ii complex. dsif and nelf promote pausing by inhibition of the transcription elongation factor tfiis/s-ii. tfiis/s-ii binds to rna polymerase ii at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. cleavage of blocked transcripts by rna polymerase ii promotes the resumption of transcription from the new 3@#$%& terminus and may allow repeated attempts at transcription through natural pause sites. dsif can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the hiv- 1 nuclear transcriptional activator, tat. dsif acts to suppress transcriptional pausing in transcripts derived from the hiv-1 ltr and blocks premature release of hiv-1 transcripts at terminator sequences.
7719	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
7720	subunit of the splicing factor sf3a required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex.
7721	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
7722	seems to be required for the activation of 5-lo (5- lipoxygenase). flap could play an essential role in the transfer of arachidonic acid to 5-lo. flap binds to mk-886, a compound that blocks the biosynthesis of leukotrienes.
7723	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
7724	may be a dna-binding protein with a regulatory function. may play an important role in cell death and/or in regulation of cell proliferation.
7725	the gamma-ctf peptide, c30, is a potent enhancer of neuronal apoptosis (by similarity).
7726	non-covalently associates with membrane glycoproteins of the killer-cell inhibitory receptor (kir) family without an itim in their cytoplasmic domain. crosslinking of kir-tyrobp complexes results in cellular activation.
7727	transcription factor that appears to be required for the t-cell-receptor-mediated trans activation of hiv-2 gene expression. binds specifically to two purine-rich motifs in the hiv-2 enhancer. transcriptionally activates the lyn and mouse blk promoters.
7728	
7729	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
7730	putative odorant receptor.
7731	
7732	involved in the metabolism of neuropeptides under 20 amino acid residues long. involved in cytoplasmic peptide degradation. able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.
7733	
7734	could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. essential for embryonic development. protects from radiation and oxidative damage (by similarity).
7735	snare that may function to receive vesicles either from the golgi stack or from the endosome.
7736	snare that may function to receive vesicles either from the golgi stack or from the endosome.
7737	dna-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (ig)/t-cell receptor gene segments. seems to recognize single-stranded dna ends generated by staggered breaks occuring at recombination hot spots.
7738	may be involved in limb tendon and ligament development (by similarity).
7739	this is a receptor for secretin. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
7740	transcriptional modulator activated by bmp (bone morphogenetic proteins) type 1 receptor kinase. smad9 is a receptor-regulated smad (r-smad).
7741	catalyzes the removal of elemental sulfur from cysteine to produce alanine. it supplies the inorganic sulfur for iron- sulfur (fe-s) clusters.
7742	involved in the presentation of foreign antigens to the immune system.
7743	converts testosterone (t) into 5-alpha- dihydrotestosterone (dht) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. it plays a central role in sexual differentiation and androgen physiology.
7744	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
7745	mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient.
7746	
7747	may be involved in protein trafficking.
7748	ampk is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-coa carboxylase. also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-coa reductase and hormone- sensitive lipase. this is a regulatory subunit.
7749	
7750	component of a multi-subunit complex involved in microtubule based vesicle motility. it is associated with the centrosome.
7751	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
7752	non-specific receptor for endothelin 1, 2, and 3. mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system.
7753	this is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
7754	required for the high affinity binding of interleukin 18 (il-18) to its receptor complex (by similarity). together with il18r1 mediates il-18-dependent activation of nf-kappa-b and jnk.
7755	
7756	
7757	
7758	
7759	
7760	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. rna polymerase i is essentially used to transcribe ribosomal dna units.
7761	
7762	
7763	
7764	may function as a ubiquitin-protein or polyubiquitin hydrolase. this deubiquitinating enzyme which functions at the endosome, is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. plays a role in signal transduction for cell growth and myc induction mediated by il-2 and gm-csf. potentiates bmp (bone morphogenetic protein) signaling by antagonizing the inhibitory action of smad6 and smad7.
7765	
7766	ig alpha is the major immunoglobulin class in body secretions. it may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
7767	
7768	likely to play a regulatory role in the development of the ventral forebrain. may play a role in craniofacial patterning and morphogenesis.
7769	likely to play a regulatory role in the development of the ventral forebrain. may play a role in craniofacial patterning and morphogenesis.
7770	
7771	
7772	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
7773	
7774	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
7775	component of the cleavage and polyadenylation specificity factor (cpsf) complex that play a key role in pre-mrna 3@#$%&-end formation, recognizing the aauaaa signal sequence and interacting with poly(a) polymerase and other factors to bring about cleavage and poly(a) addition.
7776	catalyzes the synthesis of the excitotoxin quinolinic acid (quin) from 3-hydroxyanthranilic acid. the direct product of the reaction spontaneously rearrange to quin.
7777	
7778	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
7779	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
7780	may have a function in cell cycle regulation. forms a complex with adenovirus e1a and with sv40 large t antigen. may bind and modulate functionally certain cellular proteins with which t and e1a compete for pocket binding. may act as a tumor suppressor. potent inhibitor of e2f-mediated trans-activation.
7781	
7782	transcriptionally controlled transcription factor. binds to dna sites required for the transcription of alpha 1- antitrypsin, apolipoprotein ciii, transthyretin genes and hnf1- alpha. may be essential for development of the liver, kidney and intestine.
7783	
7784	activates mpt synthase by the atp dependent adenylation of its c-terminal residue (by similarity).
7785	has a role in maintaining calcium homeostasis. catalyzes the nadph-dependent 24-hydroxylation of 25-hydroxyvitamin d(3) in the presence of adrenodoxin and nadph-adrenodoxin reductase.
7786	
7787	part of the complex catalyzing the transfer of n- acetylglucosamine from udp-n-acetylglucosamine to phosphatidylinositol, the first step of gpi biosynthesis.
7788	probable immunoglobulin-like cell surface receptor.
7789	
7790	
7791	this protein is an auxiliary protein of dna polymerase delta and is involved in the control of eukaryotic dna replication by increasing the polymerase@#$%&s processibility during elongation of the leading strand.
7792	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this form has a role in retina signal transduction.
7793	promotes endothelial cell sprouting and actin cytoskeletal reorganization. may be involved in angiogenesis. may function in ca(2+) signaling.
7794	
7795	
7796	component of the escrt-iii complex, which is required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs. the mvb pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. the escrt-iii complex is probably involved in the concentration of mvb cargo. in the escrt-iii complex, it probably serves as an acceptor for escrt-i complex on endosomal membranes. in case of infection, the hiv-1 virus takes advantage of the escrt-iii complex for budding and exocytic cargos of viral proteins, via the association of chmp4 proteins with pdcd6ip/aip1, a protein directly recruited by hiv-1 p6 protein that functions at sites of viral gag assembly and budding.
7797	component of the gpi transamidase complex. may be involved in the recognition of either the gpi attachment signal or the lipid portion of gpi.
7798	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. may play an important role in retinal development.
7799	
7800	collagen type iii occurs in most soft connective tissues along with type i collagen.
7801	
7802	
7803	part of the receptor for interferon gamma. required for signal transduction. this accessory factor is an integral part of the ifn-gamma signal transduction pathway and is likely to interact with gaf, jak1, and/or jak2.
7804	collagen type iii occurs in most soft connective tissues along with type i collagen.
7805	catalyzes the reduction of a wide variety of carbonyl compounds including the antitumor anthracycline antibiotics. can convert prostaglandin e2 to prostaglandin f2-alpha.
7806	
7807	
7808	
7809	transporter for the intake of folate. uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a v-type h(+)-pump.
7810	plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. this phosphodiesterase has a high affinity for cgmp.
7811	
7812	
7813	involved in multiple membrane trafficking steps.
7814	associates with the ig-mu chain to form a molecular complex that is expressed on the surface of pre-b-cells. this complex presumably regulates ig gene rearrangements in the early steps of b-cell differentiation.
7815	
7816	
7817	
7818	
7819	although its physiological function is unclear, it can inhibit neutrophil cathepsin g and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
7820	carrier protein. binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. binds with high affinity to alpha-tocopherol. also binds with a weaker affinity to other tocopherols and to tocotrienols. may have a transcriptional activatory activity via its association with alpha-tocopherol. probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
7821	
7822	probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
7823	
7824	formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. other thiol compounds, besides cyanide, can act as sulfur ion acceptors. also has weak mercaptopyruvate sulfurtransferase (mst) activity (by similarity).
7825	the h1@#$%&/h1.0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division. structurally and functionally the h1@#$%& family appears intermediate with respect to the h1 and h5 families.
7826	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling. phosphorylates dvl1.
7827	
7828	
7829	may be required for the assembly pathway of mitochondrial outer membrane proteins (by similarity).
7830	
7831	responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. plays a role in myoblast differentiation and also in the down- regulation of cyclin d1 in response to hypoxia in adrenal cells suggesting mapk12 may inhibit cell proliferation while promoting differentiation.
7832	
7833	may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of e4tf1. in tumor cell lines, may induce apoptosis.
7834	
7835	may be involved in transcriptional regulation.
7836	involved in transport of cations (potential).
7837	
7838	transcription factor, master regulator of tracheal cell fates in the embryo, necessary for the development of the salivary gland duct and the posterior spiracles. it may induce a general fate of branched tubular structures of epithelial origin. heterodimers of tgo/trh are involved in the control of breathless expression.
7839	required for protein transport from the er to the golgi complex.
7840	involved in the regulation of cell adhesion and in signal transduction through the wnt pathway.
7841	involved in the regulation of cell adhesion and in signal transduction through the wnt pathway.
7842	
7843	
7844	
7845	may be involved in protein transport (by similarity).
7846	
7847	
7848	
7849	general protein kinase capable of phosphorylating several known proteins. phosphorylates tbc1d4. signals downstream of phosphatidylinositol 3-kinase (pi(3)k) to mediate the effects of various growth factors such as platelet-derived growth factor (pdgf), epidermal growth factor (egf), insulin and insulin-like growth factor i (igf-i). plays a role in glucose transport by mediating insulin-induced translocation of the glut4 glucose transporter to the cell surface. mediates the antiapoptotic effects of igf-i. mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4e-bp1 and in insulin-induced activation of p70 s6 kinase. promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.
7850	
7851	microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
7852	has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (drf1). induces microspike formation, in vivo (by similarity). in vitro, stimulates n-wasp- induced arp2/3 complex activation in the absence of cdc42 (by similarity). may play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. implicated in regulation of actin polymerization and cell adhesion.
7853	
7854	
7855	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
7856	possible tumor suppressor.
7857	has a threefold preference for the hydrolysis of atp over adp.
7858	senses changes in the extracellular concentration of calcium ions. the activity of this receptor is mediated by a g- protein that activates a phosphatidylinositol-calcium second messenger system.
7859	
7860	
7861	
7862	
7863	
7864	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
7865	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
7866	plays an important role in fat metabolism. it preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
7867	e3 ubiquitin-protein ligase which accepts ubiquitin from specific e2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. negatively regulates tcr (t-cell receptor), bcr (b- cell receptor) and fcer1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. in naive t-cells, inhibits vav1 activation upon tcr engagement and imposes a requirement for cd28 costimulation for proliferation and il-2 production. also acts by promoting pik3r1/p85 ubiquitination, which impairs its recruitment to the tcr and subsequent activation. in activated t- cells, inhibits plcg1 activation and calcium mobilization upon restimulation and promotes anergy. in b-cells, acts by ubiquitinating syk and promoting its proteasomal degradation. may also be involved in egfr ubiquitination and internalization.
7868	required for assembly of the mitotic spindle. interact with spindle microtubules to produce an outwardly directed force acting upon the poles. following spindle assembly, cin8 and kip1 apparently act to oppose a force that draws separated poles back together. this force seems to be mediate by kar3.
7869	interacts with lrp1/alpha-2-macroglobulin receptor and glycoprotein 330.
7870	general vesicular transport factor required for intercisternal transport in the golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. may well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (by similarity).
7871	
7872	
7873	
7874	c/ebp are dna-binding proteins that recognize two different motifs: the ccaat homology common to many promoters and the enhanced core homology common to many enhancers.
7875	participates in the innate immune response to microbial agents. may be involved in the recognition of ds-rna. acts via myd88 and traf6, leading to nf-kappa-b activation, cytokine secretion and the inflammatory response (by similarity).
7876	
7877	may be involved in the regulation of dopamine release and transport. soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). induces fibrillization of microtubule- associated protein tau. reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation.
7878	cytokine that stimulates the proliferation of t- lymphocytes. stimulation by il-15 requires interaction of il-15 with components of il-2r, including il-2r beta and probably il-2r gamma but not il-2r alpha.
7879	
7880	
7881	
7882	receptor that binds both pdgfa and pdgfb and has a tyrosine-protein kinase activity.
7883	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
7884	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
7885	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
7886	involved in the presentation of foreign antigens to the immune system.
7887	
7888	
7889	
7890	involved in the activation cascade of caspases responsible for apoptosis execution. cleaves poly(adp-ribose) polymerase in vitro, as well as lamins. overexpression promotes programmed cell death (by similarity).
7891	
7892	appears to have dual functions such as cytoplasmic retention of attached nf-kappa-b proteins and generation of p50 by a cotranslational processing. the proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of nfkb1/p105 also appears to occur posttranslationally. p50 binds to the kappa-b consensus sequence 5@#$%&-ggrnnyycc-3@#$%&, located in the enhancer region of genes involved in immune response and acute phase reactions. plays a role in the regulation of apoptosis.
7893	
7894	probable histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a central role in histone code. demethylation of lys residue generates formaldehyde and succinate. may be involved in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes (by similarity).
7895	may play a role in notch signaling (by similarity).
7896	
7897	
7898	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
7899	
7900	vinexin alpha isoform promotes up-regulation of actin stress fiber formation. vinexin beta isoform plays a role in cell spreading and enhances the activation of jnk/sapk in response to egf stimulation by using its third sh3 domain.
7901	
7902	type i collagen is a member of group i collagen (fibrillar forming collagen).
7903	may play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles.
7904	ubiquitin ligase protein which is a component of the n- end rule pathway. recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the n-end rule, leading to their ubiquitination and subsequent degradation.
7905	has e3 ubiquitin ligase activity. the ccr4-not complex functions as general transcription regulation complex.
7906	
7907	required for protein transport from the er to the golgi complex.
7908	ucp are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from atp synthesis. as a result, energy is dissipated in the form of heat.
7909	
7910	
7911	
7912	
7913	
7914	
7915	
7916	
7917	
7918	
7919	
7920	
7921	
7922	may have a role in host defense.
7923	
7924	
7925	heparin-binding protein, with mitogenic activity for fibroblasts.
7926	
7927	
7928	membrane-cytoskeleton linker. the neural-specific isoforms may participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of ranvier and axonal initial segments.
7929	
7930	component of the escrt-iii complex, which is required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs. the mvb pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. the escrt-iii complex is probably involved in the concentration of mvb cargo. in the escrt-iii complex, it probably serves as an acceptor for escrt-i complex on endosomal membranes. in case of infection, the hiv-1 virus takes advantage of the escrt-iii complex for budding and exocytic cargos of viral proteins, via the association of chmp4 proteins with pdcd6ip/aip1, a protein directly recruited by hiv-1 p6 protein that functions at sites of viral gag assembly and budding.
7931	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
7932	
7933	katacalcin is a potent plasma calcium-lowering peptide.
7934	mediates selective neuronal growth and axon targeting. contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. essential for normal growth of the hyppocampal mossy fiber projection (by similarity).
7935	may function as a dna-binding transcription factor. binds to the macrophage-specific tpa-responsive element (mte) of the hmox1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
7936	
7937	vasorelaxant activity. has a cgmp-stimulating activity.
7938	serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. after activation by auto-catalytic cleavage it cleaves c2 and c4, leading to their activation and to the formation of c3 convertase.
7939	
7940	
7941	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
7942	may function as a testis specific transcription factor. binds dna in conjunction with gtf2a2 and tbp (the tata-binding protein) and together with gtf2a2, allows mrna transcription.
7943	
7944	
7945	has antiviral, antibacterial and anticancer activities.
7946	
7947	may regulate the disassembly of focal adhesions. may localize receptor-like tyrosine phosphatases type 2a at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
7948	
7949	
7950	receptor for vegfc. has a tyrosine-protein kinase activity.
7951	transcriptional regulator. isoform ii binds to the promoter region of s15 chorion gene, whereas isoform ii binds to cf2 promoter, thus having a probable autoregulatory role.
7952	converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. it plays a central role in sexual differentiation and androgen physiology.
7953	
7954	
7955	important modulator in the hla class ii restricted antigen presentation pathway by interaction with the hla-dm molecule.
7956	
7957	catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3@#$%&- diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.
7958	seems to act as a glycogen-targeting subunit for pp1. pp1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.
7959	may play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia (by similarity).
7960	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to g(i)-alpha and g(q)-alpha (by similarity).
7961	involved in accumulation of zinc in synaptic vesicles (by similarity).
7962	
7963	
7964	
7965	
7966	binds to the sequences 5@#$%&-aatgtaggtca-3@#$%& and 5@#$%&- ataactaggtca-3@#$%&. acts as a potent competitive repressor of ror alpha function (by similarity).
7967	involved in the degradation of prenylated proteins. cleaves the thioether bond of prenyl-l-cysteines, such as farnesylcysteine and geranylgeranylcysteine.
7968	
7969	
7970	required for membrane traffic to the vacuole.
7971	
7972	
7973	plays a role in transcriptional coactivation.
7974	l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists.
7975	heparin binding mitogenic protein. has neurite extension activity.
7976	incorporated into fibronectin-containing matrix fibers. may play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ecm). could be important for certain developmental processes and contribute to the supramolecular organization of ecm architecture, in particular to those of basement membranes. has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. may play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. could play a significant role in modulating the neurotrophic activities of app, particularly soluble app.
7977	receptor for acidic and basic fibroblast growth factors.
7978	has a transcriptional repressor activity by cooperating with epc1. induces apoptosis by activating jun n-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. may function in male germ cell development. has dna-binding activity and preferentially bound to double-stranded dna (by similarity).
7979	
7980	catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (spp), a lipid mediator with both intra- and extracellular functions. also acts on d-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as d,l-threo-dihydrosphingosine, n,n-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
7981	
7982	
7983	
7984	acts as a receptor for sonic hedgehog (shh), indian hedgehog (ihh) and desert hedgehog (dhh). associates with the smoothened protein (smo) to transduce the hedgehog@#$%&s proteins signal. seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
7985	may be involved in protein trafficking from the plasma membrane to the early endosome (ee) as well as in homotypic fusion of endocytic organelles. mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.
7986	involved in the cornified cell envelope formation. multifunctional epidermal matrix protein.
7987	
7988	
7989	regulates cdk7, the catalytic subunit of the cdk- activating kinase (cak) enzymatic complex. cak activates the cyclin-associated kinases cdc2/cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation. cak complexed to the core-tfiih basal transcription factor activates rna polymerase ii by serine phosphorylation of the repetitive c-terminus domain (ctd) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts. involved in cell cycle control and in rna transcription by rna polymerase ii. its expression and activity are constant throughout the cell cycle.
7990	may function as a transcription factor.
7991	orphan receptor.
7992	microtubule-based anterograde translocator for membranous organelles (by similarity).
7993	
7994	catalyzes the posttranslational formation of 4- hydroxyproline in -xaa-pro-gly- sequences in collagens and other proteins.
7995	
7996	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules (by similarity).
7997	may be involved in transcriptional regulation.
7998	plays an essential role in splicing, either prior to, or during splicing a complex formation.
7999	
8000	could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
8001	
8002	may function as suppressor of malignant melanoma. it may exert its effects through interactions with the cytoskeleton.
8003	may function as suppressor of malignant melanoma. it may exert its effects through interactions with the cytoskeleton.
8004	crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. the beta-2 subunit causes an increase in the plasma membrane surface area and in its folding into microvilli. interacts with tnr may play a crucial role in clustering and regulation of activity of sodium channels at nodes of ranvier.
8005	
8006	
8007	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds 5@#$%& to its own homeobox.
8008	promotes guanine-nucleotide exchange on arf1 and arf3. promotes the activation of arf1/arf3 through replacement of gdp with gtp.
8009	
8010	
8011	
8012	
8013	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
8014	guanine nucleotide-releasing protein that binds to sh3 domain of crk and grb2/ash. transduces signals from crk to activate ras.
8015	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
8016	the 26s protease is involved in the atp-dependent degradation of ubiquitinated proteins. the regulatory (or atpase) complex confers atp dependency and substrate specificity to the 26s complex. positive modulator of tat-mediated transactivation.
8017	essential bifunctional enzyme that catalyzes both the n- deacetylation and the n-sulfation of glucosamine (glcnac) of the glycosaminoglycan in heparan sulfate. modifies the glcnac-glca dissacharide repeating sugar backbone to make n-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. plays a role in determining the extent and pattern of sulfation of heparan sulfate. compared to other ndst enzymes, its presence is absolutely required. participates in biosynthesis of heparan sulfate that can ultimately serve as l- selectin ligands, thereby playing a role in inflammatory response.
8018	
8019	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
8020	interacts with zinc finger protein a20/tnfaip3 and inhibits tnf-induced nf-kappa-b-dependent gene expression by interfering with an rip- or traf2-mediated transactivation signal (by similarity). increases cell surface cd4(t4) antigen expression. interacts with hiv-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. may regulate matrix nuclear localization, both nuclear import of pic (preintegration complex) and export of gag polyprotein and viral genomic rna during virion production.
8021	
8022	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins.
8023	
8024	
8025	phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin i.
8026	thought to be important for regulating terminal differentiation and/or proliferation.
8027	
8028	
8029	
8030	repressor of hla-dra transcription. binds to the x-box motif of mhc class ii genes. may play an important role in regulating the duration of an inflammatory response by limiting the period in which mhc class ii molecules are induced by interferon-gamma. mediates e2-dependent ubiquitination.
8031	type i collagen is a member of group i collagen (fibrillar forming collagen).
8032	does not seem to have ndk kinase activity. confers protection from cell death by bax and alters the cellular levels of several antioxidant enzymes including gpx5. may play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species.
8033	
8034	transcriptional repressor of genes that require a bhlh protein for their transcription (by similarity).
8035	involved in rna splicing. is required for the association of u4/u6 snrnp with u5 snrnp in an early step of spliceosome assembly.
8036	receptor for bradykinin. it is associated with g proteins that activate a phosphatidylinositol-calcium second messenger system.
8037	noh-1s is a voltage-gated proton channel that mediates the h(+) currents of resting phagocytes and other tissues. it participates in the regulation of cellular ph and is blocked by zinc. noh-1l is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct h(+) ions as part of its electron transport mechanism, whereas noh-1s does not contain an electron transport chain.
8038	this transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. it is the rate-limiting enzyme of sterol biosynthesis.
8039	posttranslational modification of specific protein by attachment of biotin. acts on various carboxylases such as acetyl- coa-carboxylase, pyruvate carboxylase, propionyl coa carboxylase, and 3-methylcrotonyl coa carboxylase.
8040	functions as a component of the pcaf complex. the pcaf complex is capable of efficiently acetylating histones in a nucleosomal context. the pcaf complex could be considered as the human version of the yeast saga complex. also known as a coactivator for p53/tp53-dependent transcriptional activation.
8041	catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of nad. it is the rate limiting component in the mammalian nad biosynthesis pathway (by similarity).
8042	mediates selective neuronal growth and axon targeting. contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. essential for normal growth of the hyppocampal mossy fiber projection.
8043	
8044	
8045	
8046	
8047	
8048	
8049	part of a post-splicing multiprotein complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. associates preferentially with mrnas produced by splicing. does not interact with pre-mrnas, introns, or mrnas produced from intronless cdnas. associates with both nuclear mrnas and newly exported cytoplasmic mrnas. complex with magoh is a component of the nonsense mediated decay (nmd) pathway.
8050	
8051	involved in t-cell antigen receptor mediated signaling.
8052	
8053	
8054	the reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of dna to another.
8055	
8056	
8057	
8058	
8059	binds crf and inactivates it. may prevent inappropriate pituitary-adrenal stimulation in pregnancy.
8060	
8061	this receptor binds insulin-like growth factor 1 (igf1) with a high affinity and igf2 with a lower affinity. it has a tyrosine-protein kinase activity, which is necessary for the activation of the igf1-stimulated downstream signaling cascade.
8062	
8063	may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of e4tf1. in tumor cell lines, may induce apoptosis.
8064	transcriptional repressor of a number of genes including sp1 target genes.
8065	
8066	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
8067	il-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of b-cells into ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
8068	involved in ph regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. major proton extruding system driven by the inward sodium ion chemical gradient. plays an important role in signal transduction.
8069	
8070	
8071	
8072	
8073	
8074	
8075	phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
8076	probable transcription factor. may play an important role in recruitment of elf4 into pml nuclear bodies.
8077	major acute phase reactant. apolipoprotein of the hdl complex.
8078	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
8079	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
8080	
8081	
8082	
8083	
8084	
8085	transcriptional regulator that acts as repressor or activator. binds to maf recognition elements (mare). play important roles in coordinating transcription activation and repression by mafk.
8086	
8087	
8088	
8089	
8090	
8091	
8092	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
8093	
8094	may activate nf-kappa-b and jnk and promote apoptosis.
8095	may contribute to the transparency and refractive index of the lens.
8096	
8097	
8098	may play a role in cerebellar development.
8099	binds to the b1a response-element.
8100	
8101	
8102	angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
8103	
8104	stimulates the dissociation of gdp from the ras-related rala and ralb gtpases which allows gtp binding and activation of the gtpases. interacts and acts as an effector molecule for r-ras, h-ras, k-ras, and rap.
8105	may be involved in transcriptional regulation.
8106	involved in cytokinesis (potential).
8107	
8108	
8109	
8110	
8111	
8112	putative odorant receptor.
8113	this proteoglycan is a major component of extracellular matrix of cartilagenous tissues. a major function of this protein is to resist compression in cartilage. it binds avidly to hyaluronic acid via an n-terminal globular region.
8114	
8115	important modulator in the hla class ii restricted antigen presentation pathway by interaction with the hla-dm molecule.
8116	involved in the uptake of gaba and glycine into the synaptic vesicles.
8117	probably involved in rna transcription.
8118	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
8119	
8120	may play an important role in spermatogenesis and/or testis development.
8121	
8122	type i collagen is a member of group i collagen (fibrillar forming collagen).
8123	
8124	
8125	
8126	promotes the exchange of gdp by gtp (by similarity).
8127	
8128	
8129	
8130	
8131	f-actin capping proteins bind in a ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
8132	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells. cadherin 23 may function as hair bundle organizer perhaps by cross-linking the stereocilia (by similarity).
8133	histone h3, along with histone h4, plays a central role in nucleosome formation.
8134	may play a role in normal synaptic function, probably through regulation of ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals. modulator of cacna1f, shifting the activation range to more hyperpolarized voltages (by similarity).
8135	nup98 and nup96 play a role in the bidirectional transport across the nucleoporin complex (npc). the repeat domain in nup98 has a direct role in the transport.
8136	
8137	histone h4, along with histone h3, plays a central role in nucleosome formation.
8138	
8139	may function in chaperone-mediated protein folding.
8140	
8141	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (by similarity). probably encodes a dihydropyridine-insensitive current. vital for survival to adulthood.
8142	
8143	
8144	
8145	
8146	
8147	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
8148	
8149	scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. necessary for recycling of internalized adrb2. was first known to play a role in the regulation of the activity and subcellular location of slc9a3. necessary for camp-mediated phosphorylation and inhibition of slc9a3. may enhance wnt signaling.
8150	likely to play a regulatory role in the development of the ventral forebrain. may play a role in craniofacial patterning and morphogenesis.
8151	
8152	
8153	serine/threonine protein kinase required for spore wall development.
8154	muscle contraction.
8155	
8156	
8157	catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine.
8158	
8159	seems to act as a chloride ion channel.
8160	
8161	
8162	
8163	
8164	
8165	
8166	
8167	
8168	binds to type ii regulatory subunits of protein kinase a. scaffolding protein that assembles several protein kinases and phosphatases on centrosome and golgi apparatus where physiological events can be regulated by phosphorylation state of protein substrates. isoform 4/yotiao is associated with the n-methyl-d- aspartate receptor and is specifically found in the neuromuscular junction (nmj) as well as in neuronal synapses explaining that its role may be to organize postsynaptic specializations.
8169	important modulator in the hla class ii restricted antigen presentation pathway by interaction with the hla-dm molecule.
8170	orphan nuclear receptor.
8171	seems to play a role in testicular function. may be a trophic hormone with a role in testicular descent in fetal life. is a ligand for lgr8 receptor.
8172	hgf is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. it has no detectable protease activity.
8173	
8174	
8175	
8176	
8177	
8178	
8179	
8180	plays a role in the import of cytosolically synthesized preproteins into mitochondria. binds the mature portion of precursor proteins. interacts with cellular components, and possesses weak atpase activity. may be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.
8181	
8182	enhances nf-kappa-b, srf and ap1 transactivation.
8183	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
8184	nuclear hormone receptor. the steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
8185	receptor for glutamate. the activity of this receptor is mediated by a g-protein that activates a phosphatidylinositol- calcium second messenger system. may participate in the central action of glutamate in the cns, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
8186	
8187	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
8188	
8189	may be involved in transcriptional regulation.
8190	
8191	
8192	
8193	
8194	
8195	
8196	may be involved in coupling the protein kinase c and calmodulin signal transduction systems.
8197	
8198	
8199	
8200	
8201	
8202	
8203	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
8204	glandular kallikreins cleave met-lys and arg-ser bonds in kininogen to release lys-bradykinin.
8205	
8206	may be involved in nucleolar-cytoplasmic transport. may play a fundamental role in early embryonic development, particularly in development of the craniofacial complex (by similarity).
8207	acts as a cofactor for xpo1/crm1-mediated nuclear export, perhaps as export complex scaffolding protein. bound to xpo1/crm1, stabilizes the xpo1/crm1-cargo interaction. in the absence of ran-bound gtp prevents binding of xpo1/crm1 to the nuclear pore complex. binds to chc1/rcc1 and increases the guanine nucleotide exchange activity of chc1/rcc1. recruits xpo1/crm1 to chc1/rcc1 in a ran-dependent manner.
8208	
8209	
8210	
8211	
8212	
8213	
8214	
8215	
8216	
8217	
8218	
8219	
8220	
8221	vital for proper neuronal development and hatching.
8222	conversion of dopamine to noradrenaline.
8223	
8224	transcriptional activator; dna-binding protein that specifically recognize the sequence 5@#$%&-yaac[gt]g-3@#$%&. plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
8225	
8226	the normal physiological role of blm hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug blm (a glycopeptide) by hydrolyzing the carboxamide bond of its b- aminoalaninamide moiety thus protecting normal and malignant cells from blm toxicity (by similarity).
8227	
8228	involved in cannabinoid-induced cns effects through g- protein mediated inhibition of adenylate cyclase. could be a receptor for anandamide.
8229	collagen vi acts as a cell-binding protein.
8230	
8231	
8232	
8233	involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole.
8234	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
8235	involved in transcriptional regulation. represses the transcription of a number of genes including gastrin and ornithine decarboxylase. binds to the g-rich box in the enhancer region of these genes.
8236	
8237	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. displays high levels of activity on medium- and long chain acyl coas.
8238	
8239	
8240	
8241	splicing factor that in its dephosphorylated form acts as a general repressor of pre-mrna splicing. seems to interfere with the u1 snrnp 5@#$%&-splice recognition of snrp70. required for splicing repression in m-phase cells and after heat shock. may be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
8242	plays an important role in the regulation of microtubule (mt) dynamics, regulating the density, length distribution and stability of interphase mts. participates in generating polarized mt networks in migrating fibroblasts. required at kinetochores for attached microtubules to exhibit normal dynamic behavior.
8243	collagen type iv is specific for basement membranes. vital for embryonic development.
8244	
8245	plays a major role in ketone body metabolism.
8246	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
8247	
8248	
8249	
8250	involved in transport of proteins from the cis/medial- golgi to the trans-golgi network.
8251	
8252	
8253	
8254	
8255	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes, such as ube2l3/ubcm4, and then transfers it to substrates.
8256	
8257	
8258	
8259	
8260	catalyzes the formation of the neuac-alpha-2,3-gal-beta- 1,4-glcnac-, neuac-alpha-2,3-gal-beta-1,3-glcnac- or neuac-alpha- 2,3-gal-beta-1,3-galnac- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. the highest activity is toward gal-beta-1,3-glcnac and the lowest toward gal-beta-1,3- galnac (by similarity).
8261	involved in cell adhesion. binds to cd166.
8262	
8263	
8264	
8265	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
8266	protection of cells from complement-mediated damage (by similarity).
8267	integrin alpha-x/beta-2 is a receptor for fibrinogen. it recognizes the sequence g-p-r in fibrinogen. it mediates cell-cell interaction during inflammatory responses. it is especially important in monocyte adhesion and chemotaxis.
8268	endothelins are endothelium-derived vasoconstrictor peptides.
8269	
8270	
8271	
8272	the elongin bc complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different e3 ubiquitin ligase complexes, including the von hippel-lindau ubiquitination complex cbc(vhl). by binding to bc- box motifs it seems to link target recruitment subunits, like vhl and members of the socs box family, to cullin/rbx1 modules that activate e2 ubiquitination enzymes.
8273	
8274	
8275	interacts with the viral protein-binding domain of the retinoblastoma protein.
8276	
8277	
8278	may bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. may be under transcriptional regulation of steroid hormones.
8279	
8280	
8281	
8282	
8283	this is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. catalyzes the rate-limiting conversions of tyrosine to dopa, dopa to dopa-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
8284	
8285	
8286	seems to play an essential role in cold-induced suppression of cell proliferation.
8287	
8288	may participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. may control the properties of the membrane associated cytoskeleton.
8289	inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. kcnj13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.
8290	
8291	may regulate the transcription of specific genes during normal development. may play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. implicated in the transduction of shh signal (by similarity).
8292	can act as repulsive axon guidance cues. may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (by similarity).
8293	could be a melanogenic enzyme. could represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. release of the soluble form, me20-s, could protect tumor cells from antibody mediated immunity.
8294	
8295	inhibitor of bone morphogenetic protein (bmp) function, it may regulate bmp responsiveness of osteoblasts and chondrocytes.
8296	
8297	could be involved in cell-cell interactions.
8298	transcriptional coactivator that specifically associates with either oct1 or oct2. it boosts the oct-1 mediated promoter activity and to a lesser extent, that of oct-2. it has no intrinsic dna-binding activity. it recognizes the pou domains of oct1 and oct2. it is essential for the response of b-cells to antigens and required for the formation of germinal centers.
8299	
8300	
8301	seems to act exclusively upon threonine residues (by similarity).
8302	seems to be involved in transcriptional silencing in heterochromatin-like complexes. recognizes and binds histone h3 tails methylated at lys-9, leading to epigenetic repression. may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin b receptor (lbr). involved in the formation of functional kinetochore through interaction with mis12 complex proteins.
8303	
8304	
8305	may be involved in transcriptional regulation.
8306	may serve as a @#$%!flippase@#$%! as well as a glucosyltransferase that transfers glucose to ceramide.
8307	
8308	
8309	
8310	
8311	calcium-dependent mitochondrial solute carrier (by similarity).
8312	nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. involved in the coactivation of different nuclear receptors, such as for steroids (gr and er), retinoids (rars and rxrs), thyroid hormone (trs), vitamin d3 (vdr) and prostanoids (ppars). displays histone acetyltransferase activity. also involved in the coactivation of the nf-kappa-b pathway via its interaction with the nfkb1 subunit.
8313	nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. involved in the coactivation of different nuclear receptors, such as for steroids (gr and er), retinoids (rars and rxrs), thyroid hormone (trs), vitamin d3 (vdr) and prostanoids (ppars). displays histone acetyltransferase activity. also involved in the coactivation of the nf-kappa-b pathway via its interaction with the nfkb1 subunit.
8314	degrades extracellular matrix. exhibits trypsin-like activity as defined by cleavage of synthetic substrates with arg or lys as the p1 site (by similarity).
8315	
8316	
8317	
8318	component of a protein kinase signal transduction cascade. regulates the jnk and erk5 pathways by phosphorylating and activating map2k5 and map2k7 (by similarity). plays a role in caveolae kiss-and-run dynamics.
8319	component of a protein kinase signal transduction cascade. regulates the jnk and erk5 pathways by phosphorylating and activating map2k5 and map2k7 (by similarity). plays a role in caveolae kiss-and-run dynamics.
8320	
8321	
8322	probable atp-binding rna helicase.
8323	required for protein transport from the er to the golgi complex.
8324	
8325	involved in the second step of gpi biosynthesis. de-n- acetylation of n-acetylglucosaminyl-phosphatidylinositol.
8326	sequence-specific rna-binding protein which participates in the control of pre-mrna splicing.
8327	
8328	may play a role in the regulation of protease activities during hematopoiesis.
8329	hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters (by similarity). has antioxidant activity. is not associated with high density lipoprotein. prevents ldl lipid peroxidation, reverses the oxidation of mildly oxidized ldl, and inhibits the ability of mm-ldl to induce monocyte chemotaxis.
8330	probable transcription factor that may have a role in kidney cell differentiation. has a critical role in the development of the urogenital tract, the eyes, and the cns.
8331	
8332	
8333	gtpase activator for the rho, rac and cdc42 proteins, converting them to the putatively inactive gdp-bound state. cdc42 seems to be the preferred substrate.
8334	
8335	
8336	
8337	
8338	component of the origin recognition complex (orc) that binds origins of replication. it has a role in both chromosomal replication and mating type transcriptional silencing. binds to the ars consensus sequence (acs) of origins of replication in an atp-dependent manner.
8339	sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. has no activity toward desulfated n-resulfated heparin.
8340	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i.
8341	interacts with the cytoplasmic tail of nmda receptor subunits and shaker-type potassium channels. required for synaptic plasticity associated with nmda receptor signaling. overexpression or depletion of dlg4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. may reduce the amplitude of accn3 acid-evoked currents by retaining the channel intracellularly. may regulate the intracellular trafficking of adr1b.
8342	
8343	required for protein transport from the er to the golgi complex.
8344	dsp may be an important factor in dentinogenesis. dpp may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.
8345	
8346	
8347	
8348	metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (eet).
8349	
8350	
8351	may act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
8352	
8353	modulator of polycomb-mediated repression, which can be activated either by erk, p38 and jnk. substrate of csbp. in vitro, phosphorylates hspb1, pcgf4 and tcf3.
8354	stimulates the transcription of various genes by recognizing and binding to a ccaat motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
8355	
8356	
8357	
8358	
8359	3-phosphorylates the cellular phosphoinositide ptdins- 4,5-biphosphate (ptdins(4,5)p2) to produce ptdins-3, 4,5- triiphosphate (ptdins(3,4,5)p3). links g-protein coupled receptor activation to the secondary messenger ptdins(3,4,5)p3 production.
8360	stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
8361	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
8362	
8363	
8364	
8365	the hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various nonbile acid organic compounds as well. it is strictly dependent on the extracellular presence of sodium.
8366	
8367	
8368	
8369	
8370	may function in combinations with otx1/2 to specify cell fates in the developing central nervous system.
8371	
8372	receptor for the tridecapeptide neurotensin. it is associated with g proteins that activate a phosphatidylinositol- calcium second messenger system.
8373	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein.
8374	
8375	binds heavy metals. contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. inhibits survival and neurite formation of cortical neurons in vitro.
8376	
8377	
8378	
8379	
8380	
8381	this protein binds preferentially and cooperatively to ss-dna. probably involved in mitochondrial dna replication.
8382	produced by activated monocytes and neutrophils and expressed at sites of inflammation. hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. gro-beta(5-73) shows a highly enhanced hematopoietic activity.
8383	plays an essential role in autophagy (by similarity).
8384	
8385	
8386	
8387	
8388	
8389	
8390	part of the rfx complex that binds to the x-box of mhc ii promoters.
8391	
8392	
8393	
8394	rab4/rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. required for endosome fusion either homotypically or with clathrin coated vesicles. plays a role in the lysosomal trafficking of cathepsin d from the golgi to lysosomes. also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (ptdinsp3).
8395	
8396	type i collagen is a member of group i collagen (fibrillar forming collagen).
8397	
8398	putative odorant receptor. could also be involved in taste perception.
8399	gtp-binding protein with gtpase activity. elicits the formation of f-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (by similarity).
8400	important for bud site selection.
8401	
8402	this protein may be a lipid transport protein in schwann cells.
8403	cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (by similarity).
8404	
8405	oxidizes the coa-esters of 2-methyl-branched fatty acids (by similarity).
8406	noh-1s is a voltage-gated proton channel that mediates the h(+) currents of resting phagocytes and other tissues. it participates in the regulation of cellular ph and is blocked by zinc. noh-1l is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct h(+) ions as part of its electron transport mechanism, whereas noh-1s does not contain an electron transport chain.
8407	receptor for basic fibroblast growth factor. a shorter form of the receptor could be a receptor for fgf1 (afgf).
8408	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
8409	
8410	replaces conventional h2a in a subset of nucleosomes. acts as a polycomb group (pcg) protein required to maintain the transcriptionally repressive state of homeotic genes of the animal throughout development. required for histone h3 lys-9 methylation and histone h4 lys-12 acetylation, two modifications that are essential for heterochromatin formation. also involved in dna double strand break (dsb) repair. essential for early development.
8411	
8412	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
8413	
8414	
8415	
8416	
8417	plays a crucial role in coupling ngf stimulation to the activation of both ephb2 and mapk14 signaling pathways and in ngf- dependent neuronal differentiation.
8418	may play a role during embryogenesis. binds to the dna sequence 5@#$%&-gaaccaccca-3@#$%& which is part of the tre-2s regulatory element that augments the tax-dependent enhancer of human t-cell leukemia virus type 1. implicated in the transduction of shh signal.
8419	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. this component is involved in redox-linked proton pumping.
8420	
8421	
8422	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
8423	
8424	
8425	catalyzes the irreversible nadph-dependent deamination of gmp to imp. it functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of g to a nucleotides, and in maintaining the intracellular balance of a and g nucleotides. plays a role in modulating cellular differentiation.
8426	
8427	inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. may mediate the inhibitory effect of rac1 on endocytosis.
8428	implicated in the suppression of cell death. interacts with the bcl-2 and adenovirus e1b 19 kda proteins.
8429	
8430	involved in dna double strand break (dsb) repair.
8431	
8432	differentially targeted protein that binds to type i and ii regulatory subunits of protein kinase a and anchors them to the mitochondria or the plasma membrane. although the physiological relevance between pka and akaps with mitochondria is not fully understood, one idea is that bad, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored pka. it cannot be excluded too that it may facilitate pka as well as g protein signal transduction, by acting as an adapter for assembling multiprotein complexes. with its rgs domain, it could lead to the interaction to g-alpha proteins, providing a link between the signaling machinery and the downstream kinase (by similarity).
8433	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
8434	
8435	
8436	transcriptional activator that binds to e2f sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. may mediate growth factor- initiated signal transduction. it is likely involved in the early responses of resting cells to growth factor stimulation.
8437	unlikely to play an active role in the humoral immune defense. may have a function in the digestion of bacteria in the food. may be involved in the clearance of bacteria from the larval gut before metamorphosis.
8438	may function in a signal transduction pathway that is restricted to b-lymphoid cells.
8439	
8440	the function of brain maps is essentially unknown. phosphorylated map1b may play a role in the cytoskeletal changes that accompany neurite extension. possibly map1b binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules.
8441	muscle contraction.
8442	may be involved in vesicular trafficking and neurotransmitter release (by similarity).
8443	calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction.
8444	
8445	this hormone from hypothalamus regulates the release of corticotropin from pituitary gland.
8446	induces the collapse and paralysis of neuronal growth cones. could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. binds to the complex neuropilin-1/plexin-1 (by similarity).
8447	binds and exchanges gtp and gdp.
8448	extremely potent competitive inhibitor of camp-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the camp-induced dissociation of its regulatory chains.
8449	
8450	ligand for the t-cell-specific cell surface receptor icos. acts as a costimulatory signal for t-cell proliferation and cytokine secretion; induces also b-cell proliferation and differentiation into plasma cells. could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory t-cell function (by similarity).
8451	may play a role in vesicular transport from endoplasmic reticulum to golgi.
8452	
8453	weak inwardly rectifying potassium channel.
8454	binds to gc box promoters elements and selectively activates mrna synthesis from genes that contain functional recognition sites. can interact with g/c-rich motifs from serotonin receptor promoter.
8455	
8456	
8457	
8458	
8459	
8460	plays a role in transcriptional coactivation.
8461	transcriptional repressor.
8462	participates in the detoxification of a plethora of hydrazine and arylamine drugs. catalyzes the n- or o-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
8463	acts as component of the ccr4-not core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mrna deadenylase involved in mrna turnover.
8464	
8465	
8466	defensins 1/2 have antibiotic, fungicide and antiviral activities.
8467	
8468	
8469	may be an activator of the jnk/sapk pathway. phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
8470	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
8471	
8472	transcription factor required for gene expression specific to photoreceptor cells.
8473	regulates splicing and translation of various rnas. binds to (cug)n triplet repeats and to bruno response elements.
8474	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
8475	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
8476	noncatalytic subunit of the peripheral v1 complex of vacuolar atpase. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
8477	receptor for members of the ephrin-a family.
8478	
8479	
8480	
8481	may play a role in transcriptional regulation. in vitro, is associated with a kinase activity toward both rna polymerase ii c-terminal domain and cdk2 (cak).
8482	
8483	
8484	
8485	
8486	receptor for somatostatins-14 and -28. this receptor is coupled via pertussis toxin sensitive g proteins to inhibition of adenylyl cyclase. in addition it stimulates phosphotyrosine phosphatase and plc via pertussis toxin insensitive as well as sensitive g proteins. in rin-5f cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.
8487	
8488	
8489	it may be responsible for the synthesis of the sequence neuac-alpha-2,3-gal-beta-1,3-galnac- found on sugar chains o- linked to thr or ser and also as a terminal sequence on certain gangliosides. siat4a and siat4b sialylate the same acceptor substrates but exhibit different km values.
8490	
8491	it may be responsible for the synthesis of the sequence neuac-alpha-2,3-gal-beta-1,3-galnac- found on sugar chains o- linked to thr or ser and also as a terminal sequence on certain gangliosides. siat4a and siat4b sialylate the same acceptor substrates but exhibit different km values.
8492	initiates extracellular glutathione (gsh) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular gsh level. it is part of the cell antioxidant defense mechanism. catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. alternatively, glutathione can be hydrolyzed to give cys-gly and gamma glutamate.
8493	
8494	
8495	
8496	
8497	involved in accumulation of zinc in synaptic vesicles.
8498	interacts with dnak and grpe to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnak-independent fashion. unfolded proteins bind initially to dnaj; upon interaction with the dnaj-bound protein, dnak hydrolyzes its bound atp, resulting in the formation of a stable complex. grpe releases adp from dnak; atp binding to dnak triggers the release of the substrate protein, thus completing the reaction cycle. several rounds of atp-dependent interactions between dnaj, dnak and grpe are required for fully efficient folding.
8499	
8500	
8501	collagen type iv is specific for basement membranes.
8502	
8503	may be involved in maintaining golgi structure and in intra-golgi transport (by similarity).
8504	
8505	ph-dependent, voltage insensitive, outwardly rectifying potassium channel. outward rectification is lost at high external k(+) concentrations.
8506	receptor for extracellular adenine nucleotides such as atp and adp. in pancreatic islets, may mediate some of the effects of extracellular atp on insulin secretion.
8507	
8508	transcriptional factor. activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta- globin gene and represses promoters containing sp1-like binding sites inhibiting cell growth.
8509	plays a role in the sorting and targeting of vacuolar proteases.
8510	may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (by similarity).
8511	may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (by similarity).
8512	sequence-selective dna-binding protein. could play an important role in gene regulation.
8513	
8514	
8515	
8516	
8517	palmitoyltransferase specific for vac8. palmitoylates vac8 at one or more of its n-terminal cysteine residues, which is required for its proper membrane localization.
8518	
8519	
8520	
8521	plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (rrp). essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/gaba-mediated synapses (by similarity).
8522	
8523	acts as a microtubule-associated protein which interacts with cytoplasmic microtubules through beta-tubulin.
8524	
8525	
8526	
8527	functions in segment determination through interaction with genes of bithorax (bx-c) and antennapedia (ant-c) complexes. it can behave as an activator of bx-c. involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. shown to bind zinc (in vitro).
8528	
8529	dna repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. may be implicated in interstrand dna cross-link repair and in the maintenance of normal chromosome stability.
8530	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity).
8531	
8532	collagen type iv is specific for basement membranes. vital for embryonic development.
8533	rna-binding factor which binds specifically to the very 3@#$%&utr ends of both histone h1 and h3.3 mrnas, encompassing the polyadenylation signal. might play a central role in the negative regulation of histone variant synthesis in the developing brain (by similarity).
8534	
8535	defensins 1/2 have antibiotic, fungicide and antiviral activities.
8536	
8537	
8538	
8539	
8540	dna repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. may be implicated in interstrand dna cross-link repair and in the maintenance of normal chromosome stability.
8541	
8542	type i collagen is a member of group i collagen (fibrillar forming collagen).
8543	
8544	
8545	major keratinocyte cell envelope protein.
8546	required for transport of secretory proteins from the golgi complex. catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. essential for viability and secretion.
8547	
8548	
8549	can reduce the dialdehyde protein-binding form of aflatoxin b1 (afb1) to the nonbinding afb1 dialcohol. may be involved in protection of liver against the toxic and carcinogenic effects of afb1, a potent hepatocarcinogen (by similarity).
8550	
8551	
8552	phosphorylates microtubule-associated protein 2 (map2). may promote entry in the cell cycle (by similarity).
8553	
8554	
8555	
8556	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to g(i)-alpha and g(o)-alpha, but not to g(s)-alpha. may play a role in regulating the kinetics of signaling in the phototransduction cascade.
8557	influences outgrowth of olfactory axons and migration of lhrh neurons (by similarity).
8558	required for kinetochore localization of bub1.
8559	required for vacuolar assembly and vacuolar traffic.
8560	crystallins are the dominant structural components of the vertebrate eye lens.
8561	required for normal golgi function (by similarity).
8562	
8563	transcription activator which binds specifically to the mef2 element present in the regulatory regions of many muscle- specific genes. controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. may also be involved in neurogenesis and in the development of cortical architecture (by similarity). isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
8564	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
8565	
8566	has antibacterial activity (potential).
8567	
8568	
8569	
8570	
8571	
8572	
8573	
8574	transport of small lipophilic substances (potential).
8575	
8576	
8577	cleaves presequences (transit peptides) from mitochondrial protein precursors (by similarity).
8578	
8579	
8580	
8581	
8582	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
8583	
8584	mediates ubiquitination of cellular proteins.
8585	
8586	
8587	
8588	
8589	
8590	
8591	may inhibit cell replication either by catalyzing the oxidation of estrogen and androgen or by converting cortisone in cortisol.
8592	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
8593	
8594	
8595	
8596	
8597	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
8598	acts as a rac1 guanine nucleotide exchange factor (gef) and can induce membrane ruffling (by similarity).
8599	
8600	
8601	monokine with inflammatory and chemokinetic properties. binds to ccr1, ccr4 and ccr5. one of the major hiv-suppressive factors produced by cd8+ t-cells. recombinant mip-1-alpha induces a dose-dependent inhibition of different strains of hiv-1, hiv-2, and simian immunodeficiency virus (siv).
8602	binds 7-ketocholesterol.
8603	thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
8604	
8605	pyruvate carboxylase catalyzes a 2-step reaction, involving the atp-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
8606	carnitine acetylase is specific for short chain fatty acids. carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. it may be involved as well in the transport of acetyl-coa into mitochondria.
8607	may play a role in the interaction between activated b lymphocytes and dendritic cells in tonsils.
8608	receptor for thyrotropin-releasing hormone. this receptor is mediated by g proteins which activate a phosphatidylinositol-calcium second messenger system.
8609	
8610	
8611	may be involved in transcriptional regulation.
8612	catalyzes the reduction, with the use of nadp, of hydrogen sulfide into sulfite and water (by similarity).
8613	sequence-specific dna-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. ap-2 factors bind to the consensus sequence 5@#$%&-gccnnnggc-3@#$%& and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. they also suppress a number of genes including mcam/muc18, c/ebp alpha and myc. ap-2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
8614	the reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of dna to another.
8615	
8616	may regulate the subcellular localization of cip/waf1.
8617	may regulate the subcellular localization of cip/waf1.
8618	may act as a transcriptional activator. binds the caccc core sequence. may be involved in the differentiation of epithelial cells and may also function in the development of the skeleton and kidney.
8619	
8620	
8621	
8622	
8623	
8624	
8625	
8626	
8627	
8628	
8629	transcription factor, which may be involved in craniofacial development, in odontogenesis and in stomach organogenesis. may have a role in the differentiation of molars from incisors. binds to a regulatory module of the ncam promoter.
8630	
8631	
8632	
8633	component of the polycomb group (pcg) multiprotein prc1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including hox genes, throughout development. pcg prc1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone h2a lys-119, rendering chromatin heritably changed in its expressibility.
8634	
8635	
8636	
8637	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
8638	
8639	
8640	protein phosphatase 1 (pp1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. involved in regulation of ionic conductances and long-term synaptic plasticity. may play an important role in dephosphorylating substrates such as the postsynaptic density-associated ca(2+)/calmodulin dependent protein kinase ii.
8641	
8642	may regulate vesicle trafficking and modulate the subcellular distribution of slc2a4/glut4-vesicles. has parp activity and can modify terf1, and thereby contribute to the regulation of telomere length.
8643	
8644	
8645	sequence-selective dna-binding protein. could play an important role in gene regulation.
8646	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
8647	
8648	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
8649	
8650	
8651	
8652	may function as an adapter molecule that regulates traf3-mediated jnk activation (by similarity).
8653	
8654	forms calcium-sensitive (by similarity) chloride channels. may conduct other physiologically significant anions such as bicarbonate (by similarity).
8655	
8656	type i collagen is a member of group i collagen (fibrillar forming collagen).
8657	associates with ikaros at centromeric heterochromatin.
8658	
8659	
8660	mediates iodide uptake in the thyroid gland.
8661	
8662	
8663	orphan nuclear receptor.
8664	potential mediator of cell growth. pro-apoptotic.
8665	implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2a, regulation of mrna trafficking and stability in association with elavl1, and inhibition of acetyltransferases as part of the inhat (inhibitor of histone acetyltransferases) complex.
8666	
8667	the exact function of this protein is not known. it is probably a receptor with a tyrosine-protein kinase activity.
8668	
8669	receptor for glutamate. the activity of this receptor is mediated by a g-protein that inhibits adenylate cyclase activity.
8670	type i collagen is a member of group i collagen (fibrillar forming collagen).
8671	
8672	
8673	may be involved in transcriptional regulation.
8674	
8675	
8676	
8677	integrin alpha-iib/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. it recognizes the sequence r-g-d in a wide array of ligands. it recognizes the sequence h-h-l-g-g-g-a-k-q-a-g-d-v in fibrinogen gamma chain. following activation integrin alpha- iib/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. this step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
8678	
8679	
8680	
8681	component of the exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity.
8682	
8683	non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via g-protein coupled receptor (gpcr) occupancy by ligands such as bombesin or lysophosphatidic acid, or via ldl receptor occupancy. plays a potential role in oncogenic transformations resulting in increased kinase activity.
8684	
8685	
8686	
8687	
8688	acts as a sequence-specific transcriptional repressor in association with bcl6. may function in a narrow stage or be related to some events in the early b-cell development.
8689	
8690	
8691	
8692	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
8693	possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis (by similarity).
8694	tp and tp5 may play a role in t-cell development and function. tp5 is an immunomodulating pentapeptide.
8695	bifunctional mrna capping enzyme exhibiting rna 5@#$%&- triphosphatase activity in the n-terminal part and mrna guanylyltransferase activity in the c-terminal part. catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5@#$%&-triphosphate end of nascent mrna to yield a diphosphate end, and by transferring the gmp moiety of gtp to the 5@#$%&-diphosphate terminus.
8696	
8697	
8698	may be required for testis development.
8699	major high molecular weight protein of desmosomes. involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
8700	
8701	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction (by similarity).
8702	
8703	
8704	
8705	
8706	
8707	transports l-glutamate; the l-glutamate uptake is sodium- and voltage-dependent and chloride-independent. the eaat5- associated chloride conductance may participate in visual processing.
8708	it has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1. it is essential for growth or germination at 37 degrees celsius. may have a role in the heat shock response. involved in trna splicing and cell separation.
8709	accelerates osteoblast differentiation (by similarity).
8710	
8711	may play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage.
8712	inhibits gdp/gtp exchange reaction of rhob. interacts specifically with the gdp- and gtp-bound forms of post- translationally processed rhob and rhog proteins, both of which show a growth-regulated expression in mammalian cells. stimulates the release of the gdp-bound but not the gtp-bound rhob protein. also inhibits the gdp/gtp exchange of rhob but shows less ability to inhibit the dissociation of prebound gtp.
8713	
8714	transcriptional regulator. isoform ii binds to the promoter region of s15 chorion gene, whereas isoform ii binds to cf2 promoter, thus having a probable autoregulatory role.
8715	required for protein transport from the er to the golgi complex.
8716	
8717	
8718	processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. involved in melanosome transport. may also be required for some polarization process involved in dendrite formation.
8719	mediates transcriptional repression by certain nuclear receptors. part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.
8720	
8721	
8722	
8723	stimulates specifically the gtpase activity of ypt6.
8724	required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors. may bind a rab gtpase such as vps21.
8725	
8726	xenin stimulates exocrine pancreatic secretion. it inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. in the gut, xenin interacts with the neurotensin receptor.
8727	
8728	may be involved in transcriptional regulation.
8729	
8730	stabilizes the cyclin h-cdk7 complex to form a functional cdk-activating kinase (cak) enzymatic complex. cak activates the cyclin-associated kinases cdc2/cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation. cak complexed to the core-tfiih basal transcription factor activates rna polymerase ii by serine phosphorylation of the repetitive c-terminus domain (ctd) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts. involved in cell cycle control and in rna transcription by rna polymerase ii.
8731	transfers a sulfate group to the hydroxyl group at c3 of nonreducing beta-galactosyl residues. acts both on type 1 (gal- beta-1,3-glcnac) and type 2 (gal-beta-1,4-glcnac) chains with similar efficiency.
8732	
8733	
8734	
8735	
8736	
8737	
8738	
8739	
8740	core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal dna. component of several complexes which regulate chromatin metabolism. these include the chromatin assembly factor 1 (caf-1) complex, which is required for chromatin assembly following dna replication and dna repair; the core histone deacetylase (hdac) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodelling and histone deacetylase complex (the nurd complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the prc2/eed-ezh2 complex, which promotes repression of homeotic genes during development.
8741	
8742	
8743	
8744	
8745	
8746	
8747	
8748	
8749	
8750	
8751	
8752	
8753	
8754	caspase-like protease, which plays a central role in the chromosome segregation by cleaving the scc1/rad21 subunit of the cohesin complex at the onset of anaphase. during most of the cell cycle, it is inactivated by different mechanisms.
8755	
8756	
8757	thrombin, which cleaves bonds after arg and lys, converts fibrinogen to fibrin and activates factors v, vii, viii, xiii, and, in complex with thrombomodulin, protein c.
8758	
8759	removes 5-oxoproline from various penultimate amino acid residues except l-proline (by similarity).
8760	acts as a sequence specific dna binding transcriptional activator or repressor. the isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. may be required in conjunction with tp73/p73 for initiation of tp53/p53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. involved in notch signaling by probably inducing jag1 and jag2. plays a role in the regulation of epithelial morphogenesis. the ratio of deltan-type and ta*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. required for limb formation from the apical ectodermal ridge.
8761	
8762	receptor for atrial natriuretic peptide. does not have guanylate cyclase activity.
8763	
8764	
8765	
8766	may function in membrane trafficking. exhibits calcium- dependent phospholipid binding properties (by similarity). may have a role in synaptic plasticity.
8767	involved in gonadal development (by similarity).
8768	
8769	
8770	
8771	
8772	
8773	
8774	
8775	
8776	
8777	
8778	component of multiple cytoplasmic organelles. apparently crucial for their normal development and function. may be involved in intracellular protein sorting.
8779	may be involved in transcriptional regulation.
8780	
8781	lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of nf-kappa-b and its transcriptional activity. induces the processing of nf-kappa-b 2/p100. could act in a receptor-selective manner (by similarity).
8782	
8783	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
8784	
8785	may play a role in neuron-specific rna processing.
8786	l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists.
8787	negative regulator of the heat shock response. negatively affects hsf1 dna-binding activity. may have a role in the suppression of the activation of the stress response during the aging process.
8788	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel. in the uterus, the function of the receptor appears to be related to tissue contractility. the binding of this pi subunit with other gaba(a) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
8789	transports ca(2+) in exchange for either li(+) or na(+), explaining how li(+) catalyzes ca(2+) exchange. in contrast to other members of the family its function is independent of k(+).
8790	
8791	
8792	
8793	transcription factor that is thought to be involved in regulation of organogenesis. may be involved in determination and maintenance of retina formation. binds a 5@#$%&-ggtgtcag-3@#$%& motif present in the are regulatory element of atp1a1. binds a 5@#$%&- tca[ag][ag]ttnc-3@#$%& motif present in the mef3 element in the myogenin promoter, and in the igfbp5 promoter (by similarity). thought to be regulated by association with dach and eya proteins, and seems to be coactivated by eya1, eya2 and eya3 (by similarity).
8794	
8795	
8796	transcriptional repressor.
8797	
8798	
8799	converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. may function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes.
8800	
8801	
8802	
8803	
8804	
8805	transcription factor.
8806	
8807	probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. can be blocked by extracellular barium or cesium.
8808	receptor for msh (alpha, beta and gamma) and acth. the activity of this receptor is mediated by g proteins which activate adenylate cyclase.
8809	
8810	binds to activated cdc42 but does not stimulate its gtpase activity. it associates with calmodulin. could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. may promote neurite outgrowth.
8811	
8812	
8813	
8814	putative atp-dependent rna helicase.
8815	
8816	required for protein transport from the er to the golgi complex.
8817	
8818	integrin alpha-l/beta-2 is a receptor for icam1, icam2, icam3 and icam4. integrins alpha-m/beta-2 and alpha-x/beta-2 are receptors for the ic3b fragment of the third complement component and for fibrinogen. integrin alpha-x/beta-2 recognizes the sequence g-p-r in fibrinogen alpha-chain. integrin alpha-m/beta-2 recognizes p1 and p2 peptides of fibrinogen gamma chain. integrin alpha-m/beta-2 is also a receptor for factor x. integrin alpha- d/beta-2 is a receptor for icam3 and vcam1.
8819	
8820	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
8821	plays an important role in the degradation of some oligopeptides.
8822	
8823	involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole.
8824	cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a bmp-inhibitory mechanism. can regulate nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (by similarity).
8825	cytokine that inhibits the activity of bmp2 and bmp4 in a dose-dependent manner. antagonized bmp4-induced suppression of progesterone production in granulosa cells (by similarity).
8826	
8827	
8828	acts as a low affinity receptor for nicotinic acid and mediate its anti-lipolytic effect through a g(i)-protein-mediated inhibition of adenylyl cyclase. this pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
8829	protein kinase acting as a corepressor of several transcription factors, including smad1 and pou4f1/brn3a and probably nk homeodomain transcription factors. inhibits cell growth and promotes apoptosis. involved in transcriptional activation of tp53 and tp73. phosphorylation of tp53 may be mediated by a tp53-hipk2-axin1 complex. in response to tgfb, cooperates with daxx to activate jnk (by similarity). phosphorylates the antiapoptotic factor ctbp1 and promotes its proteasomal degradation. in the wnt/beta-catenin signaling pathway acts as an intermediate kinase between tak1 and nlk to promote the proteasomal degradation of c-myb.
8830	
8831	
8832	
8833	inhibits factor x (x(a)) directly and, in a xa-dependent way, inhibits viia/tissue factor activity, presumably by forming a quaternary xa/laci/viia/tf complex. it possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
8834	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
8835	
8836	
8837	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
8838	
8839	
8840	
8841	
8842	
8843	
8844	
8845	
8846	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
8847	may have direct activity on the actin cytoskeleton. induces actin polymerization and redistribution. contributes with nck1 and grb2 in the recruitment and activation of wasl. may participate in regulating the subcellular localization of wasl, resulting in the disassembly of stress fibers in favor of filopodia formation (by similarity). plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting wasl to vaccinia virus.
8848	
8849	
8850	
8851	
8852	inhibits nf-kappa-b by complexing with and trapping it in the cytoplasm. however, the unphosphorylated form resynthesized after cell stimulation is able to bind nf-kappa-b allowing its transport to the nucleus and protecting it to further ikba- dependent inactivation. association with inhibitor kappa b- interacting nkiras1 and nkiras2 prevent its phosphorylation rendering it more resistant to degradation, explaining its the slower degradation.
8853	redirects newly synthesized mhc class i heavy chains via the sec61 translocon to the cytosol where they undergo proteasome- dependent destruction. in consequence, infected cells are masked for immune recognition by cytotoxic t-lymphocytes.
8854	may be involved in transcriptional regulation.
8855	
8856	
8857	may be involved in the axonal growth during development by transducing signals from different semaphorins.
8858	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.
8859	
8860	
8861	
8862	
8863	promotes the exchange of ras-bound gdp by gtp.
8864	
8865	
8866	involved in the biosynthesis of gangliosides gm2, gd2 and ga2.
8867	
8868	
8869	
8870	
8871	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (by similarity).
8872	
8873	
8874	type x collagen is a product of hyperthrophic chondrotocytes and has been localized to presumptive mineralization zones of hyaline cartilage.
8875	
8876	sodium-independent transporter of chloride and iodide.
8877	functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit kpnb1. acting autonomously, is thought to serve itself as receptor for nuclear localization signals (nls) and to promote translocation of import substrates through the nuclear pore complex (npc) by an energy requiring, ran-dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. mediates autonomously the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in association with kpnb1 mediates the nuclear import of h1 histone and the ran-binding site of ipo7 is not required but synergizes with that of kpnb1 in importin/substrate complex dissociation. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones. in vitro, mediates the nuclear import of hiv-1 reverse transcription complex (rtc) integrase.
8878	motor required for the retrograde transport of golgi vesicles to the endoplasmic reticulum. has a microtubule plus end- directed motility.
8879	phosphorylase is an important allosteric enzyme in carbohydrate metabolism. enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. however, all known phosphorylases share catalytic and structural properties.
8880	involved in the vesicular transport of biogenic amines.
8881	
8882	may participate in forming intercisternal cross-bridges of the golgi complex.
8883	putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. preferentially binds to alpha2,6-linked sialic acid. the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. in the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their sh2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. induces apoptosis in acute myeloid leukemia (in vitro).
8884	
8885	
8886	
8887	protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function.
8888	
8889	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
8890	
8891	may have an important role in dna metabolism.
8892	
8893	produces atp from adp in the presence of a proton gradient across the membrane. the beta chain is the catalytic subunit.
8894	receptor for glutamate. the activity of this receptor is mediated by a g-protein that inhibits adenylate cyclase activity. may mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
8895	specifically binds to the upstream regulatory region of type i ifn and ifn-inducible mhc class i genes (the interferon consensus sequence (ics)). plays a negative regulatory role in cells of the immune system.
8896	activates e box-dependent transcription in collaboration with tcf3/e47, but the activity is completely antagonized by the negative regulator of neurogenesis hes1. may play a role in the differentiation of subsets of neural cells by activating e box- dependent transcription (by similarity).
8897	
8898	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
8899	
8900	
8901	may function as a signaling adapter protein in lymphocytes (by similarity).
8902	down-regulates the expression of several chemokine receptors. interferes with hiv-1 replication by suppressing tat- induced viral ltr promoter activity.
8903	
8904	implicated in the control of cell fate decisions during development.
8905	
8906	
8907	
8908	receptor that binds both pdgfa and pdgfb and has a tyrosine-protein kinase activity.
8909	the gpib-v-ix complex functions as the von willebrand factor receptor and mediates von willebrand factor-dependent platelet adhesion to blood vessels. the adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. gp-ix may provide for membrane insertion and orientation of gp-ib.
8910	
8911	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
8912	induces stromal cells to produce proinflammatory and hematopoietic cytokines (by similarity).
8913	
8914	
8915	
8916	
8917	
8918	
8919	muscle contraction.
8920	
8921	involved in transcriptional activation and repression of select genes by chromatin remodelling (alteration of dna- nucleosome topology). required for the coactivation of estrogen responsive promoters by swi/snf complexes and the src/p160 family of histone acetyltransferases (hats). also specifically interacts with the corest corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.
8922	
8923	promotes guanine-nucleotide exchange on arf1 and arf3. promotes the activation of arf1/arf3 through replacement of gdp with gtp.
8924	
8925	
8926	
8927	
8928	
8929	
8930	
8931	
8932	
8933	
8934	
8935	
8936	
8937	kinase that may play a role in mitotic regulation.
8938	component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. has a role in the correct positioning of the septum. required for anchoring mad2l1 to the nuclear periphery.
8939	may play a role in terminally differentiated neurons. has a ser/thr-phosphorylating activity for histone h1 (by similarity).
8940	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
8941	essential for transcriptional activity of the hla class ii promoter; activation is via the proximal promoter. no dna binding of in vitro translated ciita was detected. may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal mhc class ii promoter, to elements of the transcription machinery, or both. alternatively it may activate hla class ii transcription by modifying proteins that bind to the mhc class ii promoter.
8942	type i collagen is a member of group i collagen (fibrillar forming collagen).
8943	
8944	
8945	
8946	transport of phosphorylated lysosomal enzymes from the golgi complex and the cell surface to lysosomes. lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low ph mediates the dissociation of the complex. this receptor also binds igf2.
8947	
8948	
8949	inhibits the transcriptional activity of spi1 in a dose- dependent manner (by similarity).
8950	
8951	
8952	acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (by similarity). causes reduced proliferation of b-lymphocytes.
8953	may be involved in collagen fiber assembly (by similarity).
8954	integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis.
8955	
8956	
8957	involved in regulation of actin cytoskeleton organization and endocytosis.
8958	required for protein transport from the er to the golgi complex.
8959	
8960	may function as a transcription factor with dual roles in transcription initiation and termination. binds to two sites, me1a1 and me1a2, within the c-myc promoter having greater affinity for the former. also binds to multiple g/c-rich sites within the promoter of the sp1 family of transcription factors.
8961	may function as a transcription factor with dual roles in transcription initiation and termination. binds to two sites, me1a1 and me1a2, within the c-myc promoter having greater affinity for the former. also binds to multiple g/c-rich sites within the promoter of the sp1 family of transcription factors.
8962	may function as an adapter molecule that regulates traf3-mediated jnk activation (by similarity).
8963	adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. may link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. may play a role in the regulation of secretory granules via its interaction with ptprn.
8964	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
8965	hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
8966	may play a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.
8967	plays an important role in the degradation of dermatan and keratan sulfates.
8968	may bind dna (by similarity).
8969	
8970	
8971	ppiases accelerate the folding of proteins during protein synthesis.
8972	
8973	
8974	
8975	
8976	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
8977	
8978	
8979	
8980	type i collagen is a member of group i collagen (fibrillar forming collagen).
8981	
8982	regulatory protein which represses transcription and augments histone deacetylase activity of hdac1. may have a potential role in tumor suppressor pathways (by similarity).
8983	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
8984	
8985	
8986	may be involved in tissue-specific alternative rna processing events.
8987	
8988	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
8989	probably involved in egf and insulin receptor signaling.
8990	
8991	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
8992	
8993	this is a membrane-bound, calcium-inhibitable adenylyl cyclase.
8994	
8995	
8996	
8997	
8998	involved in the replication of mitochondrial dna.
8999	
9000	
9001	
9002	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
9003	anti-proliferative protein inhibits cell cycle progression from the g0/g1 to s phases.
9004	gtpase-activating protein for the adp ribosylation factor family.
9005	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb.
9006	
9007	
9008	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
9009	
9010	
9011	
9012	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
9013	acts as a low affinity receptor for nicotinic acid and mediate its anti-lipolytic effect through a g(i)-protein-mediated inhibition of adenylyl cyclase. this pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
9014	involved in the transport of chloride ions. may regulate bicarbonate secretion and salvage in epithelial cells by regulating the slc4a7 transporter.
9015	
9016	
9017	putative odorant receptor.
9018	
9019	
9020	
9021	
9022	
9023	may play a role in the regulation of sterol metabolism. binds a range of oxysterols.
9024	may be a regulated effector of stress granule assembly. phosphorylation-dependent sequence-specific endoribonuclease in vitro. cleaves exclusively between cytosine and adenine and cleaves c-myc mrna preferentially at the 3@#$%&utr. atp- and magnesium-dependent helicase. unwinds preferentially partial dna and rna duplexes having a 17 bp annealed portion and either a hanging 3@#$%& tail or hanging tails at both 5@#$%& and 3@#$%& ends. unwinds dna/dna, rna/dna, and rna/rna substrates with comparable efficiency. acts unidirectionally by moving in the 5@#$%& to 3@#$%& direction along the bound single-stranded dna.
9025	the smn complex plays an essential role in spliceosomal snrnp assembly in the cytoplasm and is required for pre-mrna splicing in the nucleus. it may also play a role in the metabolism of snornps.
9026	component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. three proteases; ndl, gd and snk process easter to create active easter. active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the tl receptor in the ventral region of the embryo. promotes heterophilic cellular adhesion. spz c-106 in the hemolymph controls expression of the antifungal peptide drosomycin (drs) by acting as a ligand of tl and inducing an intracellular signaling pathway.
9027	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
9028	
9029	
9030	promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
9031	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
9032	regulator of notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. probably acts both as a positive and negative regulator of notch, depending on the developmental and cell context (by similarity). functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the notch pathway via some ubiquitin ligase activity.
9033	
9034	
9035	
9036	furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the rx(k/r)r consensus motif.
9037	
9038	
9039	
9040	
9041	
9042	rapidly transports ca(2+) during excitation-contraction coupling. ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (by similarity).
9043	
9044	
9045	promotes the exchange of ras-bound gdp by gtp.
9046	
9047	
9048	
9049	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. binds the 7s rna only in presence of srp68. this ribonucleoprotein complex might interact directly with the docking protein in the er membrane and possibly participate in the elongation arrest function.
9050	
9051	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. receptor for tgf-beta.
9052	
9053	this protein is probably a serine/threonine protein kinase.
9054	probable transcription regulator.
9055	probable transcription regulator.
9056	catalyzes the exchange of adp and atp across the mitochondrial inner membrane. may participate in the formation of the permeability transition pore complex (ptpc) responsible for the release of mitochondrial products that triggers apoptosis.
9057	catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of nadph.
9058	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of calcium out of the cell.
9059	
9060	involved in recruiting unphosphorylated forms of smad2/smad3 to the tgf-beta receptor by controlling their subcellular localization and by interacting and colocalizing with the tgf-beta receptor. phosphorylation of smad2/smad3 induces dissociation from zfyve9 and formation of smad2/smad4 complexes and nuclear translocation.
9061	
9062	
9063	
9064	
9065	may play a role in the control of gene expression.
9066	ena/vasp proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodelling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. enah induces the formation of f-actin rich outgrowths in fibroblasts. acts syngeristically with baiap2alpha and downstream of ntn1 to promote filipodia formation. required for the actin-based mobility of listeria monocytogenes (by similarity).
9067	
9068	
9069	
9070	promotes the exchange of ras-bound gdp by gtp.
9071	
9072	
9073	transcriptional repressor.
9074	
9075	component of the u3 small nucleolar ribonucleoprotein. required for the early cleavages at sites a0, a1 and a2 during 18s ribosomal pre-rna processing.
9076	
9077	
9078	muscle contraction.
9079	
9080	
9081	may be a negative regulator of transcription, but can activate transcription when coexpressed with ras, src or mos. forms a ternary complex with the serum response factor and the ets and srf motifs of the fos serum response element.
9082	orphan receptor that binds dna as a monomer to hormone response elements (hre) containing an extended core motif half- site sequence 5@#$%&-aaggtca-3@#$%& in which the 5@#$%& flanking nucleotides participate in determining receptor specificity. may be required for brain development. may be involved in the regulation of retinal development (by similarity).
9083	
9084	neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. the complex formed with nos1 and capon proteins is necessary for specific nitric-oxid functions at a presynaptic level.
9085	
9086	
9087	
9088	
9089	may play a role in the regulation of rna biogenesis and/or mitosis. in vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone h1.
9090	component of cohesin complex, a complex required for the cohesion of sister chromatids after dna replication. the cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. at anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. the cohesin complex may also play a role in spindle pole assembly during mitosis.
9091	
9092	
9093	essential component of the tim23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
9094	may play an important role in ckii- and p60c-src-induced signal transduction cascades (by similarity).
9095	
9096	isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
9097	
9098	
9099	
9100	
9101	may be involved in transcriptional regulation.
9102	fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
9103	
9104	
9105	participates in signal transduction in hematopoietic cells. adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. acts as an e3 ubiquitin-protein ligase, which accepts ubiquitin from specific e2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. recognizes activated receptor tyrosine kinases, including pdgfa, egf and csf1, and terminates signaling.
9106	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
9107	
9108	may play a role in telomeric silencing. acetylates soluble but not nucleosomal h4 at lys-5 and lys-12 and acetylates histone h2a at lys-5. hat1 has intrinsic substrate specificity that modifies lysine in recognition sequence gxgkxg.
9109	
9110	
9111	
9112	
9113	transcriptional repressor.
9114	
9115	
9116	
9117	
9118	
9119	
9120	
9121	
9122	
9123	it is able to complement the radiosensitivity defect of an ataxia telangiectasia (at) fibroblast cell line.
9124	protease that may play a role in t-cell development.
9125	
9126	
9127	involved in the assembly or repair of the [fe-s] clusters present in iron-sulfur proteins. binds iron.
9128	
9129	
9130	
9131	essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.
9132	
9133	
9134	
9135	binds to and inhibits the transcriptional repressor zbtb33, which may lead to activation of target genes of the wnt signaling pathway (by similarity). may associate with and regulate the cell adhesion properties of both c- and e-cadherins. implicated both in cell transformation by src and in ligand- induced receptor signaling through the egf, pdgf, csf-1 and erbb2 receptors.
9136	
9137	
9138	seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. isoform a1 binds only to the receptor edar, while isoform a2 binds exclusively to the receptor xedar.
9139	
9140	this is a receptor for interleukin-9.
9141	may be involved in tissue injury and remodeling. has significant elastolytic activity. can accept large and small amino acids at the p1@#$%& site, but has a preference for leucine. aromatic or hydrophobic residues are preferred at the p1 site, with small hydrophobic residues (preferably alanine) occupying p3.
9142	transcriptional activator. binds the consensus sequence 5@#$%&-dhwattgaytwwd-3@#$%& on a variety of gene promoters such as those of hnf3b and ttr. important for liver genes transcription.
9143	mediates the nuclear export of aminoacylated trnas. in the nucleus binds to trna and to the gtpase ran in its active gtp- bound form. docking of this trimeric complex to the nuclear pore complex (npc) is mediated through binding to nucleoporins. upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of ran-gtp to ran-gdp (induced by ranbp1 and rangap1, respectively) cause release of the trna from the export receptor. xpot then return to the nuclear compartment and mediate another round of transport. the directionality of nuclear export is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus.
9144	receptor for prostacyclin (prostaglandin i2 or pgi2). the activity of this receptor is mediated by g(s) proteins which activate adenylate cyclase.
9145	
9146	
9147	
9148	produces pentose sugars for nucleic acid synthesis and main producer of nadph reducing power.
9149	
9150	may be a dna-binding protein or transcriptional factor.
9151	
9152	
9153	may be involved in collagen fiber assembly (by similarity).
9154	component of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends. also a component of rnase mrp.
9155	
9156	acts as dominant repressor towards other family members. inhibits nf-kappa-b-regulated gene expression. may be required for the initiation and maintenance of the differentiated state.
9157	
9158	
9159	receptor for progesterone (by similarity). may be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) immunotoxicity.
9160	
9161	
9162	
9163	binds dna as a heterodimer with max and represses transcription. binds to the canonical e box sequence 5@#$%&-cacgtg-3@#$%& and, with higher affinity, to 5@#$%&-cacgcg-3@#$%&.
9164	the ube2v2/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through lys- 63. this type of poly-ubiquitination does not lead to protein degradation by the proteasome. mediates transcriptional activation of target genes. plays a role in the control of progress through the cell cycle and differentiation. plays a role in the error-free dna repair pathway and contributes to the survival of cells after dna damage.
9165	this is a receptor for retinoic acid. this metabolite has profound effects on vertebrate development. retinoic acid is a morphogen and is a powerful teratogen. this receptor controls cell function by directly regulating gene expression.
9166	
9167	
9168	
9169	
9170	participates in control of cell volume in low-osmolarity conditions.
9171	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
9172	
9173	
9174	essential for cartilage morphogenesis and joint formation. inhibitor of bone morphogenetic proteins (bmp) signaling which is required for growth and patterning of the neural tube and somite (by similarity).
9175	
9176	
9177	
9178	
9179	in vitro; can phosphorylate exogenous substrates on ser and thr residues. may be involved in the regulation of cellular growth and/or development.
9180	
9181	
9182	
9183	collagen type iii occurs in most soft connective tissues along with type i collagen.
9184	
9185	
9186	involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. may play a role in the specification or differentiation of one or more subsets of epicardial cell types.
9187	
9188	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (by similarity). has angiogenic inhibitor activity. active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture.
9189	
9190	
9191	
9192	
9193	
9194	
9195	binds to regulatory subunit (rii) of protein kinase a. may be involved in establishing polarity in signaling systems or in integrating pka-rii isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by camp (by similarity).
9196	this protein may be involved in b-cell activation. may also be involved in signal transduction and gene regulation.
9197	collagen type iii occurs in most soft connective tissues along with type i collagen.
9198	
9199	gtpase-activating protein for rhoa, and perhaps for cdc42. may be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. acts a tumor suppressor in hepatocellular carcinoma cells.
9200	
9201	
9202	probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. likely to be involved in key signaling pathways crucial for normal limb development. may participate in wnt signaling.
9203	
9204	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
9205	
9206	transcriptional corepressor that binds to a number of transcription factors. inhibits the transcriptional activation mediated by ctnnb1 and tcf family members in wnt signaling. the effects of full-length tle family members may be modulated by association with dominant-negative aes (by similarity).
9207	mediates gpi anchoring in the endoplasmic reticulum, by replacing a protein@#$%&s c-terminal gpi attachment signal peptide with a pre-assembled gpi. during this transamidation reaction, the gpi transamidase forms a carbonyl intermediate with the substrate protein.
9208	
9209	
9210	component of the circadian clock or downstream effector of clock function. exhibits a high amplitude circadian rhythm with maximal levels in early evening. in constant darkness or constant light, the amplitude of the rhythm decreases (by similarity).
9211	cell surface receptor for reelin (reln) and apolipoprotein e (apoe)-containing ligands. lrp8 participates in transmitting the extracellular reelin signal to intracellular signaling processes, by binding to dab1 on its cytoplasmic tail. reelin acts via both the vldl receptor (vldlr) and lrp8 to regulate dab1 tyrosine phosphorylation and microtubule function in neurons. lrp8 has higher affinity for reelin than vldlr. lrp8 is thus a key component of the reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. binds the endoplasmic reticulum resident receptor-associated protein (rap). binds dimers of beta 2-glycoprotein i and may be involved in the suppression of platelet aggregation in the vasculature. highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (phgpx), two proteins required for sperm maturation. may also function as an endocytic receptor.
9212	
9213	
9214	
9215	
9216	
9217	receptor for the mip-3-beta chemokine. probable mediator of ebv effects on b-lymphocytes or of normal lymphocyte functions.
9218	
9219	important in cell-cell recognition. appears to function in leukocyte-endothelial cell adhesion. interacts with the beta-1 integrin vla4 on leukocytes, and mediates both adhesion and signal transduction. the vcam1/vla4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
9220	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity.
9221	
9222	
9223	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes.
9224	necessary for efficient rna polymerase ii transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by s-ii allows the resumption of elongation from the new 3@#$%&terminus.
9225	
9226	terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals.
9227	promotes the exchange of ras-bound gdp by gtp.
9228	
9229	
9230	
9231	
9232	
9233	
9234	
9235	
9236	
9237	
9238	
9239	
9240	essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as notch receptors and app (beta- amyloid precursor protein). it probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
9241	
9242	
9243	probably important in the regulation of neuronal excitability. may underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. kcnq4 channels are blocked by linopirdin, xe991 and bepridil, whereas clofilium is without significant effect. muscarinic agonist oxotremorine-m strongly suppress kcnq4 current in cho cells in which cloned kcnq4 channels were coexpressed with m1 muscarinnic receptors.
9244	
9245	
9246	calcium-binding protein required for t-cell receptor-, fas-, and glucocorticoid-induced cell death. may mediate ca(2+)- regulated signals along the death pathway (by similarity).
9247	
9248	
9249	enhances dna synthesis and may play a role in cell proliferation.
9250	
9251	
9252	major keratinocyte cell envelope protein.
9253	actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (by similarity).
9254	docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. may function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. may play an important role in integrin beta-1 or b cell antigen receptor (bcr) mediated signaling in b- and t-cells. integrin beta-1 stimulation leads to recruitment of various proteins including crk, nck and shptp2 to the tyrosine phosphorylated form.
9255	
9256	
9257	
9258	belongs to an adhesion system, probably together with the e-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (ajs). nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
9259	inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. may mediate the inhibitory effect of rac1 on endocytosis.
9260	
9261	
9262	
9263	
9264	
9265	
9266	catalyzes the removal of elemental sulfur from cysteine to produce alanine. it supplies the inorganic sulfur for iron- sulfur (fe-s) clusters.
9267	calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction.
9268	
9269	plays a role in signal transduction in blood cells. contributes to both cell proliferation and survival and thus provide a selective advantage in tumorigenesis. may affect the structure or silencing of chromatin by phosphorylating hp1 gamma/cbx3.
9270	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
9271	muscle contraction.
9272	
9273	
9274	
9275	
9276	
9277	biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
9278	
9279	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
9280	guanine nucleotide exchange factor that potentially links pathways that signal through rac1, rhoa and cdc42. catalyzes guanine nucleotide exchange on rhoa and cdc42 and interacts specifically with the gtp-bound form of rac1, suggesting that it functions as an effector of rac1. may also participate in axonal transport in the brain. becomes activated and highly tumorigenic by truncation of the n-terminus.
9281	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
9282	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1e gives rise to r-type calcium currents. r-type calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group and are blocked by nickel, and partially by omega-agatoxin-iiia (omega-aga-iiia). they are however insensitive to dihydropyridines (dhp), omega- conotoxin-gvia (omega-ctx-gvia), and omega-agatoxin-iva (omega- aga-iva). calcium channels contaning alpha-1e subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
9283	probable transcription factor that may trigger apoptosis by inducing the expression of genes that are critical for cell death.
9284	
9285	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. psma2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.
9286	
9287	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
9288	
9289	
9290	
9291	
9292	gtpase that associates with pre-60s ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (by similarity).
9293	
9294	
9295	
9296	
9297	
9298	
9299	factor h functions as a cofactor in the inactivation of c3b by factor i and also increases the rate of dissociation of the c3bbb complex (c3 convertase) and the (c3b)nbb complex (c5 convertase) in the alternative complement pathway.
9300	this enzyme scavenge exogenous and endogenous cytidine and 2@#$%&-deoxycytidine for ump synthesis.
9301	
9302	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
9303	
9304	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
9305	
9306	
9307	involved in several cell fate decisions that require cell-cell interactions. it is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10.
9308	general factor that plays a major role in the activation of eukaryotic genes transcribed by rna polymerase ii.
9309	
9310	
9311	
9312	
9313	
9314	
9315	might be involved in the transport of a component required for iron utilization into or out of the mitochondria.
9316	renin is a highly specific endopeptidase, whose only known function is to generate angiotensin i from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
9317	
9318	
9319	may be involved in transcriptional regulation.
9320	receptor for the fc region of complexed or aggregated immunoglobulins gamma. low affinity receptor. involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by b- cells. binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on b-cells (bcr), t-cells (tcr) or via another fc receptor. isoform iib1 fails to mediate endocytosis or phagocytosis. isoform iib2 does not trigger phagocytosis.
9321	
9322	
9323	
9324	
9325	
9326	calcium channel protein which plays an important role in excitation-contraction coupling.
9327	
9328	phosphorylates ptdins, ptdins4p and ptdins(4,5)p2 with a preference for ptdins(4,5)p2.
9329	troponin t is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin atpase activity.
9330	
9331	
9332	
9333	
9334	stimulates the kinase activity of stk38l.
9335	
9336	
9337	
9338	
9339	
9340	binds to gt and gc boxes promoters elements. probable transcriptional activator.
9341	also acts as a tumor suppressor.
9342	negatively modulates the dna binding activity of oct-2 and therefore its transcriptional regulatory activity. could act either by binding to dna octamer or by interacting with oct-2. may also be a modulator of other octamer-binding proteins.
9343	may play a role in the signal transduction pathway mediated by multiple wnt genes.
9344	closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. displays potent endoprotease activity against fibrinogen at acid ph. may play an important role in extracellular matrix degradation.
9345	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
9346	
9347	
9348	
9349	
9350	
9351	not known. binds to rna homopolymers, with a preference for poly(g) and poly(u) and little for poly(a).
9352	
9353	
9354	
9355	may be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
9356	
9357	
9358	present throughout the cell cycle, associates with centromeres at early prophase, and remains associated with the centromere until after telophase (by similarity).
9359	may play a role in regulating the early events of spermatogenesis by binding newly synthesized histones variants and transporting them to the nucleus.
9360	
9361	required for high-affinity binding to nerve growth factor (ngf), neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor (bdnf). known substrates for the trk receptors are shc1, pi 3-kinase, and plc-gamma-1. has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. activates erk1 by either shc1- or plc-gamma-1-dependent signaling pathway.
9362	
9363	
9364	
9365	
9366	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules (by similarity).
9367	pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
9368	
9369	
9370	
9371	involved in tolerance to glucose starvation. phosphorylates atm.
9372	
9373	
9374	
9375	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1h gives rise to t-type calcium currents. t-type calcium channels belong to the @#$%!low-voltage activated (lva)@#$%! group and are strongly blocked by nickel and mibefradil. a particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. t-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. they may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
9376	
9377	
9378	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. lamin a and c are present in equal amounts in the lamina of mammals.
9379	
9380	has chymotrypsin-type protease activity and hypocalcemic activity.
9381	type i collagen is a member of group i collagen (fibrillar forming collagen).
9382	
9383	may play an important role in cell fate determination during lung development and in spermatogenesis (by similarity).
9384	coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (s300-ii) stimulates initiation of transcription. binds to both direct repeats and palindromes of the 5@#$%&-aggtca-3@#$%& motif.
9385	
9386	binds the poly(a) tail of mrna.
9387	this csf induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
9388	
9389	
9390	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.
9391	specific inhibition of calpain (calcium-dependent cysteine protease). plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
9392	tumor-associated antigen.
9393	
9394	
9395	
9396	may play a role in promoting maturation and morphological differentiation of cerebellar neurons.
9397	
9398	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
9399	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters. represses transcription from promoters with atf sites. it may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
9400	
9401	
9402	
9403	dsp may be an important factor in dentinogenesis. dpp may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.
9404	branching enzyme that converts linear into branched poly-n-acetyllactosaminoglycans. introduces the blood group i antigen during embryonic development. it is closely associated with the development and maturation of erythroid cells.
9405	
9406	
9407	type i collagen is a member of group i collagen (fibrillar forming collagen).
9408	
9409	binds and is activated by neuregulins and ntak.
9410	muscle contraction.
9411	
9412	binds to and activates slc9a1/nhe1 in a serum- independent manner, thus increasing ph and protecting cells from serum deprivation-induced death.
9413	
9414	
9415	
9416	
9417	
9418	involved in cell motility. when hyaluronan binds to hmmr, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. may also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (erk) activity.
9419	type i collagen is a member of group i collagen (fibrillar forming collagen).
9420	
9421	tfiif is a general transcription initiation factor that binds to rna polymerase ii and helps to recruit it to the initiation complex in collaboration with tfiib. it promotes transcription elongation. this subunit shows atp-dependent dna- helicase activity.
9422	
9423	
9424	
9425	may play a role in the control of gene expression.
9426	
9427	orphan receptor. the activity of this receptor is mediated by g proteins which activate adenylate cyclase.
9428	has guanylyl cyclase on binding to the beta-1 subunit. the alternatively spliced isoform alpha-2-i acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.
9429	ribonucleoprotein particle composed of a single polypeptide and one of four small rna molecules. it is present in all mammalian cells studied but has no known function (by similarity).
9430	may promote functional cell surface expression of olfactory receptors.
9431	
9432	collagen type iii occurs in most soft connective tissues along with type i collagen.
9433	
9434	capable of removing ubiquitin from ubiquitinated proteins; also capable of removing nedd8 from nedd8 conjugates but has no effect on sentrin-1 conjugates.
9435	
9436	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
9437	
9438	may regulate the transcription of specific genes during normal development. may play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. implicated in the transduction of shh signal (by similarity).
9439	involved in the presentation of foreign antigens to the immune system.
9440	component of the cleavage and polyadenylation specificity factor (cpsf) complex that play a key role in pre-mrna 3@#$%&-end formation, recognizing the aauaaa signal sequence and interacting with poly(a) polymerase and other factors to bring about cleavage and poly(a) addition (by similarity).
9441	
9442	
9443	
9444	transcriptional repressor that binds specifically to the prdi element in the promoter of the beta-interferon gene. drives the maturation of b-lymphocytes into ig secreting cells.
9445	its physiological substrate seems to be the small heat shock protein (hsp27/hsp25). in vitro can phosphorylate glycogen synthase at ser-7 and tyrosine hydroxylase (on ser-19 and ser-40). this kinase phosphorylates ser in the peptide sequence, hyd-x-r- x(2)-s, where hyd is a large hydrophobic residue (by similarity). mediates both erk and p38 mapk/mapk14 dependent neutrophil responses. participates in tnf alpha-stimulated exocytosis of secretory vesicles in neutrophils. plays a role in phagocytosis- induced respiratory burst activity.
9446	may play a role in the response to environmental stress. appears to act upstream of the jun n-terminal pathway.
9447	involved in skeletal muscle regeneration, specifically at the onset of cell fusion. also involved in macrophage-derived giant cells (mgc) and osteoclast formation from mononuclear precursors (by similarity).
9448	plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
9449	
9450	
9451	binds to the fc region of immunoglobulins gamma. high affinity receptor.
9452	
9453	
9454	may be involved in several stages of intracellular trafficking (by similarity).
9455	muscle contraction.
9456	
9457	
9458	ampk is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-coa carboxylase. also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-coa reductase and hormone- sensitive lipase. this is a regulatory subunit, may be a positive regulator of ampk activity. it may also serve as an adapter molecule for the catalytic alpha-subunit.
9459	tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
9460	
9461	
9462	
9463	
9464	
9465	may play some important roles in inflammatory responses. up-regulates il-6 and tnf-alpha and induces apoptosis (by similarity).
9466	
9467	
9468	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. socs3 is involved in negative regulation of cytokines that signal through the jak/stat pathway. inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, lif, erythropoietin, insulin, il12, gcsf and leptin receptors. binding to jak2 inhibits its kinase activity. suppresses fetal liver erythropoiesis. regulates onset and maintenance of allergic responses mediated by t-helper type 2 cells. regulates il-6 signaling in vivo (by similarity).
9469	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
9470	
9471	probably acts as a co-chaperone (by similarity).
9472	probably important in the regulation of neuronal excitability. associates with kcnq3 to form a potassium channel with essentially identical properties to the channel underlying the native m-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. kcnq2/kcnq3 current is blocked by linopirdine and xe991, and activated by the anticonvulsant retigabine. muscarinic agonist oxotremorine-m strongly suppress kcnq2/kcnq3 current in cells in which cloned kcnq2/kcnq3 channels were coexpressed with m1 muscarinic receptors.
9473	may have regulatory role in cell division or differentiation in response to extracellular signals.
9474	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
9475	
9476	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. the produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
9477	mediates b-cell b-cell interactions. may be involved in the localization of b-cells in lymphoid tissues. binds sialylated glycoproteins; one of which is cd45. preferentially binds to alpha2,6-linked sialic acid. the sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of b-cell antigen receptor signaling. plays a role in positive regulation through interaction with src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their sh2 domains that block signal transduction through dephosphorylation of signaling molecules.
9478	
9479	
9480	associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mrna splicing.
9481	
9482	
9483	
9484	
9485	tfiid beta-specific tafii. interacts with tbp, and more strongly with tafii28 and tafii30.
9486	n6-methyltransferase that methylates adenosine residues of some mrnas and is essential to activate sporulation. n6- methyladenosine (m6a), which is present at internal sites of some mrnas, is probably required to initiate sporulation. positive regulator for ime2.
9487	may play a role in cell-cell and cell-matrix interactions. this is a non-catalytic metalloprotease-like protein.
9488	deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. also phosphorylates anti-viral and anti-cancer nucleoside analogs.
9489	adds the first glucose residue to the lipid-linked oligosaccharide precursor for n-linked glycosylation. transfers glucose from dolichyl phosphate glucose (dol-p-glc) onto the lipid-linked oligosaccharide man(9)glcnac(2)-pp-dol.
9490	
9491	potential tumor suppressor. acts as a phosphoinositide 3-phosphatase by regulating ptdins(3,4,5)p3 levels. involved in regulation of the akt1 signaling pathway. the unphosphorylated form cooperates with aip1 to suppress akt1 activation.
9492	
9493	
9494	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes.
9495	
9496	actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells.
9497	not known.
9498	suppresses tnf- and cd40-induced nfkb1 activity at the level of the ikk complex, by inhibiting nfkbia degradation induced by tnf. when associated with pycard, activates casp1, leading to the secretion of mature proinflammatory cytokine il1b. may be a component of the inflammasome, a protein complex which also includes pycard, card8 and casp1 and whose function would be the activation of proinflammatory caspases.
9499	
9500	
9501	
9502	seems to be required for maximal rate of protein biosynthesis. enhances ribosome dissociation into subunits and stabilizes the binding of the initiator met-trna(i) to 40 s ribosomal subunits.
9503	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
9504	inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin a. could play a role during central nervous system development (by similarity).
9505	protein kinase that is involved in mitotic regulation. may have a role at the g2-m transition. may also play a role in meiosis. isoform 1 but not isoform 2 appears to play a role in centrosome splitting. isoform 1 phosphorylates and activates nek11 in g1/s-arrested cells. isoform 2, which is not present in the nucleolus, does not.
9506	activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (apc/c). during telophase and in the subsequent g1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (d-box) and an additional degradation signal termed the ken box including ase1, cdc20, the b-type cyclins clb2 and clb3, the polo-like kinase cdc5 and hsl1, and recruits them in a c-box-dependent manner to the apc/c for ubiquitination and subsequent proteolysis. required for exit from mitosis, cytokinesis and formation of prereplicative complexes in g1. probably is the target of a bub2-dependent spindle checkpoint pathway.
9507	suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. regulates cell death by controlling the mitochondrial membrane permeability. appears to function in a feedback loop system with caspases. inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1).
9508	splicing factor that in its dephosphorylated form acts as a general repressor of pre-mrna splicing. seems to interfere with the u1 snrnp 5@#$%&-splice recognition of snrp70. required for splicing repression in m-phase cells and after heat shock. may be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
9509	
9510	
9511	lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of nf-kappa-b and its transcriptional activity. induces the processing of nf-kappa-b 2/p100. could act in a receptor-selective manner (by similarity).
9512	
9513	converts protoheme ix and farnesyl diphosphate to heme o.
9514	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form.
9515	
9516	
9517	c8 is a constituent of the membrane attack complex. c8 binds to the c5b-7 complex, forming the c5b-8 complex. c5-b8 binds c9 and acts as a catalyst in the polymerization of c9.
9518	
9519	
9520	
9521	
9522	
9523	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
9524	
9525	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
9526	
9527	
9528	
9529	
9530	modulates the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons uaa, uag and uga.
9531	calcium channel protein which plays an important role in excitation-contraction coupling.
9532	binds igf-i and igf-ii with a relatively low affinity. stimulates prostacyclin (pgi2) production.
9533	may be involved in transcriptional regulation.
9534	
9535	
9536	functions as a component of the pcaf complex. the pcaf complex is capable of efficiently acetylating histones in a nucleosomal context. the pcaf complex could be considered as the human version of the yeast saga complex.
9537	
9538	required for protein transport from the er to the golgi complex.
9539	
9540	probable role in regulating transcription of specific genes. may regulate through nfkb1 the expression of the ccl2/mcp-1 chemokine. may play a role in tumor necrosis factor alpha (tnf- alpha) gene expression.
9541	
9542	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. interacts with receptor-regulated smads specific for the bmp pathway, smad1 and smad5, in order to trigger their ubiquitination and degradation and hence their inactivation.
9543	may be involved in transcriptional regulation.
9544	essential for transcriptional activity of the hla class ii promoter; activation is via the proximal promoter. no dna binding of in vitro translated ciita was detected. may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal mhc class ii promoter, to elements of the transcription machinery, or both. alternatively it may activate hla class ii transcription by modifying proteins that bind to the mhc class ii promoter.
9545	forms a high-affinity link between the actin cytoskeleton and the membrane. isoform 2 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation.
9546	may be involved in chromatin remodeling and transcriptional regulation. may have a role in x inactivation.
9547	part of the insoluble cornified cell envelope (ce) of stratified squamous epithelia.
9548	
9549	component of the polycomb group (pcg) multiprotein prc1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including hox genes, throughout development. pcg prc1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone h2a lys-119, rendering chromatin heritably changed in its expressibility.
9550	seems to act exclusively upon threonine residues (by similarity).
9551	arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
9552	transcription factor which binds specifically to the mef2 element present in the regulatory regions of many muscle- specific genes. activates transcription via this element. may be involved in muscle-specific and/or growth factor-related transcription.
9553	
9554	
9555	protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. they compact sperm dna into a highly condensed, stable and inactive complex.
9556	
9557	
9558	may overlap in function with tropomyosin and may be involved in organization of actin filaments. acts as a multicopy suppressor of rho3 mutation. rna-binding protein which may modulate mrna translation. involved in heme regulation of hap1, as a component of the high-molecular-weight complex (hmc).
9559	
9560	
9561	
9562	may be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.
9563	
9564	
9565	
9566	
9567	
9568	
9569	type i collagen is a member of group i collagen (fibrillar forming collagen).
9570	
9571	substrate-recognition component of the scf (skp1-cul1-f- box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. regulates the stability of ctnnb1 and participates in wnt signaling.
9572	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
9573	
9574	
9575	collagen type iii occurs in most soft connective tissues along with type i collagen.
9576	
9577	orphan receptor.
9578	
9579	receptor showing broad specificity for both classical and nonclassical mhc class i molecules.
9580	
9581	
9582	
9583	
9584	downstream regulator in the wnt/frizzled-signaling pathway. associated with cell survival. attenuates p53-mediated apoptosis in response to dna damage through activation of akt kinase. up-regulates the anti-apoptotic bcl-x(l) protein. adheres to skin and melanoma fibroblasts. in vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.
9585	involved in the production of gd3 and gt3 from gm3.
9586	
9587	
9588	
9589	confers strong transcriptional repression to the ap- 2alpha gene. binds to a regulatory element (a32) in the ap-2alpha gene promoter.
9590	
9591	
9592	collagen type iii occurs in most soft connective tissues along with type i collagen.
9593	may be involved in transcriptional regulation.
9594	
9595	may be involved in the regulation of spermatogenesis and sperm maturation (by similarity).
9596	
9597	probably functions in nuclear protein import as nuclear transport receptor. serves as receptor for nuclear localization signals (nls) in cargo substrates. is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (npc) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, ran-dependent mechanism. at the nucleoplasmic side of the npc, ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus (by similarity).
9598	terminal component of the liver microsomal stearyl-coa desaturase system, that utilizes o(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-coa substrates including palmitoyl-coa and stearoyl-coa.
9599	
9600	
9601	
9602	
9603	putative atp-dependent protease.
9604	binds mannose and n-acetylglucosamine in a calcium- dependent manner. is capable of host defense against pathogens, by activating the classical complement pathway independently of the antibody.
9605	catalyzes the n-oxidation of certain primary alkylamines to their oximes via an n-hydroxylamine intermediate. inactive toward certain tertiary amines, such as imipramine or chloropromazine. can catalyze the s-oxidation of methimazole. the truncated form is catalytically inactive.
9606	involved in neurogenesis. also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (by similarity).
9607	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
9608	may function in cell cycle regulation.
9609	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb (by similarity).
9610	
9611	
9612	
9613	
9614	may act as a gtpase activating protein for rab family protein(s).
9615	the beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating g protein inhibition and controlling the alpha-1 subunit membrane targeting.
9616	
9617	
9618	actin-associated protein that may play a role in modulating actin-based shape (by similarity).
9619	
9620	
9621	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes and then transfers it to substrates (by similarity).
9622	
9623	
9624	
9625	
9626	
9627	receptor for atp that acts as a ligand gated ion channel (by similarity).
9628	may be involved in transcriptional regulation.
9629	may play a role in the regulation of psen2 proteolytic processing and apoptosis. together with psen2 involved in modulation of beta-amyloid formation.
9630	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
9631	appears to have dual functions such as cytoplasmic retention of attached nf-kappa-b proteins and generation of p50 by a cotranslational processing. the proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of nfkb1/p105 also appears to occur posttranslationally. p50 binds to the kappa-b consensus sequence 5@#$%&-ggrnnyycc-3@#$%&, located in the enhancer region of genes involved in immune response and acute phase reactions. plays a role in the regulation of apoptosis.
9632	receptor for vegfc. has a tyrosine-protein kinase activity.
9633	
9634	
9635	may be involved in transcriptional regulation. coactivator for steroid receptors.
9636	
9637	
9638	
9639	
9640	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
9641	may play a role in developmental myelination of peripheral nerves.
9642	
9643	required for protein transport from the er to the golgi complex.
9644	
9645	converts lysophosphatidic acid (lpa) into phosphatidic acid by incorporating acyl moiety at the 2 position (by similarity).
9646	
9647	
9648	
9649	may have e3 ubiquitin ligase activity.
9650	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release.
9651	
9652	
9653	
9654	
9655	not yet known, orphan transporter.
9656	may be involved in the initiation of hepatocyte growth (by similarity).
9657	may play an important role during the embryonic development and differentiation of the central nervous system.
9658	
9659	gap class segmentation protein that controls development of head structures.
9660	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
9661	has antibacterial activity (potential).
9662	
9663	
9664	transcription factor that binds to the enhancer element pre-i (positive regulatory element-i) of the il-4 gene. might change the dna-binding specificity of other transcription factors and recruit them to unusual dna sites.
9665	
9666	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
9667	
9668	may associate with cd21. may regulate the release of ca(2+) from intracellular stores.
9669	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (by similarity).
9670	can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
9671	
9672	plays a role in hyaluronan/hyaluronic acid (ha) synthesis.
9673	may be involved in transcriptional regulation.
9674	
9675	important for the resorption of phosphate by the kidney. may be involved in actively transporting phosphate into cells via na(+) cotransport in the renal brush border membrane.
9676	orphan receptor.
9677	has broad nucleoside selectivity (uridine, ademosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes.
9678	
9679	
9680	
9681	
9682	
9683	this is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. catalyzes the rate-limiting conversions of tyrosine to dopa, dopa to dopa-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
9684	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. has a sulfatase activity.
9685	
9686	ph-dependent, voltage-insensitive, background potassium channel protein. rectification direction results from potassium ion concentration on either side of the membrane. acts as an outward rectifier when external potassium concentration is low. when external potassium concentration is high, current is inward.
9687	
9688	participates in the synthesis of thyroid hormones. transfers electrons from adrenodoxin reductase to the cholesterol side chain cleavage cytochrome p450.
9689	
9690	
9691	
9692	required for preprotein translocation (by similarity).
9693	required for preprotein translocation (by similarity).
9694	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb. essential role in the control of rela transcriptional activity in response to tnf.
9695	
9696	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
9697	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
9698	thought to regulate cation conductance. may regulate accn1 and accn3 gating (by similarity).
9699	
9700	
9701	could regulate beta-glucan synthesis. overexpression provides resistance to hm-1 killer toxin.
9702	controls reversibly actin polymerization and depolymerization in a ph-sensitive manner. it has the ability to bind g- and f-actin in a 1:1 ratio of cofilin to actin. it is the major component of intranuclear and cytoplasmic actin rods.
9703	
9704	binds directly to 26s ribosomal rna (by similarity).
9705	major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of ceacam-binding microorganisms, including neissiria, moxarella and haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. responsible for rac1 stimulation in the course of pathogen phagocytosis.
9706	
9707	
9708	central enzyme in the extracellular metabolism of plasma lipoproteins. among other substrates it esterifies the free cholesterol transported in plasma lipoproteins.
9709	gtpase-activating protein for rac1 and perhaps cdc42, but not for rhoa small gtpase. may attenuate rac1 signaling in neurons.
9710	mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. also required for the transfer of beta-barrel precursors from the tom complex to the sorting and assembly machinery (sam complex) of the outer membrane. acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. the timm8-timm13 complex mediates the import of proteins such as timm23, slc25a12/aralar1 and slc25a13/aralar2, while the predominant timm9-timm10 70 kda complex mediates the import of much more proteins. probably necessary for normal neurologic development.
9711	receptor for the fc region of complexed immunoglobulins gamma. low affinity receptor.
9712	
9713	
9714	may be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. may also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
9715	
9716	
9717	
9718	
9719	
9720	
9721	
9722	
9723	calcium-binding protein required for t-cell receptor-, fas-, and glucocorticoid-induced cell death. may mediate ca(2+)- regulated signals along the death pathway (by similarity).
9724	transcription activator that binds dna cooperatively with dp proteins through the e2 recognition site, 5@#$%&-tttc[cg]cgc- 3@#$%& found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the drtf1/e2f complex functions in the control of cell-cycle progression from g1 to s phase. e2f-3 binds specifically to rb1 protein, in a cell-cycle dependent manner.
9725	
9726	may be involved in transcriptional regulation.
9727	associates with ikaros at centromeric heterochromatin.
9728	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
9729	
9730	
9731	
9732	
9733	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
9734	binds to regulatory subunit (rii) of protein kinase a. may be involved in establishing polarity in signaling systems or in integrating pka-rii isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by camp (by similarity).
9735	required for protein transport from the er to the golgi complex.
9736	involved in the activation cascade of caspases responsible for apoptosis execution. cleaves caspase-1.
9737	
9738	probable transcription regulator.
9739	involved in the activation cascade of caspases responsible for apoptosis execution. cleaves caspase-1.
9740	
9741	serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (dsbs), apoptosis and genotoxic stresses such as ionizing ultraviolet a light (uva), thereby acting as a dna damage sensor. recognizes the substrate consensus sequence [s/t-q]. phosphorylates ser-139 of histone variant h2ax/h2afx at double strand breaks (dsbs), thereby regulating dna damage response mechanism. also involved in signal transduction and cell cycle control. may function as a tumor suppressor. necessary for activation of abl1 and sapk. phosphorylates p53/tp53, fancd2, nfkbia, brca1, ctip, nibrin (nbn), terf1, rad9 and dclre1c. may play a role in vesicle and/or protein transport. could play a role in t-cell development, gonad and neurological function.
9742	
9743	dna-binding protein that specifically binds heat shock promoter elements (hse) and activates transcription. also required for growth at normal temperatures.
9744	
9745	receptor for hepatocyte growth factor and scatter factor. has a tyrosine-protein kinase activity.
9746	
9747	involved in the presentation of foreign antigens to the immune system.
9748	
9749	
9750	
9751	
9752	
9753	
9754	
9755	may be required for ribosome biogenesis.
9756	class e vps protein involved in concentration and sorting of cargo proteins of the multivesicular body (mvb) for incorporation into intralumenal vesicles. fusion between endosomes and the vacuole will then target the cargo proteins to the vacuolar lumen. acts as an adapter that recruits the doa4 deubiquitinase to the endosomes, leading to deubiquitination of cargo proteins prior to the lumenal sequestration. its association to the endosomes depends on snf7 and its dissociation requires vps4. interacts functionally with the pkc1p-mitogen-activated protein kinase pathway.
9757	
9758	may be involved in transcriptional regulation.
9759	associated with snrnp u1, u2, u4/u6 and u5.
9760	
9761	
9762	
9763	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
9764	
9765	
9766	in vitro, acts as a receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5).
9767	
9768	
9769	modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. may play a role in synapse formation during brain development.
9770	
9771	
9772	
9773	
9774	the function of subunit 4 is not yet known.
9775	
9776	
9777	may catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of vim-2, lewis a, lewis b, sialyl lewis x and lewis x/ssea-1 antigens. may be involved in blood group lewis determination; lewis-positive (le(+)) individuals have an active enzyme while lewis-negative (le(-)) individuals have an inactive enzyme.
9778	
9779	muscle contraction.
9780	catalyzes the posttranslational formation of 4- hydroxyproline in hypoxia-inducible factor (hif) alpha proteins. hydroxylates hif-1 alpha at pro-564, and hif-2 alpha. functions as a cellular oxygen sensor and, under normoxic conditions, targets hif through the hydroxylation for proteasomal degradation via the von hippel-lindau ubiquitination complex. may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. promotes cell death through a caspase-dependent mechanism (by similarity).
9781	
9782	
9783	
9784	type i collagen is a member of group i collagen (fibrillar forming collagen).
9785	
9786	during lymphocyte development, the genes encoding immunoglobulins and t-cell receptors are assembled from variable (v), diversity (d), and joining (j) gene segments. this combinatorial process, known as v(d)j recombination, allows the generation of an enormous range of binding specificities from a limited amount of genetic information. the rag1/rag2 complex initiates this process by binding to the conserved recombination signal sequences (rss) and introducing a double-strand break between the rss and the adjacent coding segment. these breaks are generated in two steps, nicking of one strand (hydrolysis), followed by hairpin formation (transesterification). rag1/2 has also been shown to function as a transposase in vitro, and to possess rss-independent endonuclease activity (end processing) and hairpin opening. rag1 alone can bind to rss but stable, efficient binding requires rag2. all known catalytic activities require the presence of both proteins.
9787	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. may play an important role in the destruction of aggrecan in arthritic diseases. could also be a critical factor in the exacerbation of neurodegeneration in alzheimer disease. cleaves aggrecan at the 392-glu-|-ala-393 site.
9788	component of the fact complex, a general chromatin factor that acts to reorganize nucleosomes. the fact complex is involved in multiple processes that require dna as a template such as mrna elongation, dna replication and dna repair. during transcription elongation the fact complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. it facilitates the passage of rna polymerase ii and transcription by promoting the dissociation of one histone h2a-h2b dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of rna polymerase ii. the fact complex is probably also involved in phosphorylation of ser-392 of p53/tp53 via its association with ck2 (casein kinase ii). binds specifically to double-stranded dna and at low levels to dna modified by the antitumor agent cisplatin. may potentiate cisplatin-induced cell death by blocking replication and repair of modified dna. also acts as a transcriptional coactivator for p63/tp73l.
9789	catalyzes the first committed step in the biosynthesis of complex n-glycans. it controls conversion of high mannose to complex n-glycans; the final hydrolytic step in the n-glycan maturation pathway.
9790	
9791	seems to promotes the survival of visceral and proprioceptive sensory neurons.
9792	may function in membrane trafficking. exhibits calcium- dependent phospholipid binding properties (by similarity).
9793	type i collagen is a member of group i collagen (fibrillar forming collagen).
9794	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
9795	type i collagen is a member of group i collagen (fibrillar forming collagen).
9796	factor h functions as a cofactor in the inactivation of c3b by factor i and also increases the rate of dissociation of the c3bbb complex (c3 convertase) and the (c3b)nbb complex (c5 convertase) in the alternative complement pathway.
9797	may be involved in transcriptional regulation.
9798	
9799	
9800	motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport (by similarity).
9801	
9802	may be involved in signal transduction as a component of a multimeric receptor complex.
9803	
9804	
9805	editing of the messenger rnas for glutamate receptor (glur) subunits by site-selective adenosine deamination. edits both the glur-b q/r and r/g sites efficiently but converts the adenosine in hotspot1 much less efficiently.
9806	may participate in meiotic recombination.
9807	glycosaminoglycans biosynthesis. involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (udp-glcua) to the common linkage region trisaccharide gal beta 1-3gal beta 1-4xyl covalently bound to a ser residue at the glycosaminylglycan attachment site of proteoglycans. can also play a role in the biosynthesis of l2/hnk- 1 carbohydrate epitope on glycoproteins. shows strict specificity for gal beta1-3gal beta1-4xyl, exhibiting negligible incorporation into other galactoside substrates including galbeta1-3gal beta1-o- benzyl, galbeta1-4glcnac and galbeta1-4glc.
9808	may have a role in promoting tumor progression. may block the tgfb1-enhanced cell growth.
9809	
9810	
9811	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. it is suggested that polr2g contributes to the function of rna polymerase ii in the absence of polr2d either in a manner independent of its association with the enzyme or by directly binding to the enzyme in a manner independent of its association with polr2d.
9812	catalyzes the posttranslational addition of a tyrosine to the c-terminal end of detyrosinated alpha-tubulin.
9813	
9814	probably involved in the metabolism of xenobiotics and of natural substrates.
9815	
9816	mediates endoplasmic reticulum to golgi transport (by similarity).
9817	
9818	bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. catalyzes the formation of 3- ketoacyl-coa intermediates from both straight-chain and 2-methyl- branched-chain fatty acids (by similarity).
9819	involved in the presentation of foreign antigens to the immune system.
9820	
9821	
9822	essential for the control of the cell cycle at the g1/s (start) transition. potentiates the transcriptional activity of atf5.
9823	required for cytoplasm to vacuole transport (cvt) vesicles and autophagosomes completion. necessary for the binding of atg18 to atg9. involved in correct atg9 trafficking through the pre-autophagosomal structure and in peroxisome degradation.
9824	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii.
9825	
9826	ligand for cd2. might facilitate interaction between activated lymphocytes. probably involved in regulating t-cell activation.
9827	
9828	
9829	
9830	
9831	
9832	participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
9833	
9834	calcium-dependent mitochondrial solute carrier (by similarity).
9835	
9836	catalyzes the covalent attachment of ubiquitin to other proteins. required for postreplication repair of uv-damaged dna. may be involved in neurite outgrowth.
9837	inhibitor of wnt signaling pathway (potential).
9838	ubiquitin ligase protein which is a component of the n- end rule pathway. recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the n-end rule, leading to their ubiquitination and subsequent degradation.
9839	adapter protein involved in the toll-like receptor and il-1 receptor signaling pathway in the innate immune response. acts via irak1, irak2 and traf6, leading to nf-kappa-b activation, cytokine secretion and the inflammatory response. increases il-8 transcription. may be involved in myeloid differentiation.
9840	required for anchoring dihydrolipoamide dehydrogenase (e3) to the dihydrolipoamide transacetylase (e2) core of the pyruvate dehydrogenase complexes of eukaryotes. this specific binding is essential for a functional pdh complex.
9841	
9842	
9843	
9844	terminal component of the liver microsomal stearyl-coa desaturase system, that utilizes o(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-coa substrates including palmitoyl-coa and stearoyl-coa.
9845	
9846	involved in accumulation of zinc in synaptic vesicles.
9847	one of the multiple factors required for polyadenylation and 3@#$%&-end cleavage of mammalian pre-mrnas. may be responsible for the interaction of cstf with other factors to form a stable complex on the pre-mrna.
9848	binds specifically and cooperatively to the sph and gt- iic @#$%!enhansons@#$%! (5@#$%&-gtggaatgt-3@#$%&) and activates transcription in vivo in a cell-specific manner. the activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (tif). involved in cardiac development. binds to the m-cat motif.
9849	
9850	
9851	associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mrna splicing (by similarity).
9852	
9853	
9854	
9855	required for protein transport from the er to the golgi complex.
9856	
9857	
9858	
9859	required for meiotic chromosome synapsis and cell cycle progression. may act as a molecular zipper to bring homologous chromosomes in close apposition. zip1 may encode the transverse filaments of the synaptonemal complex.
9860	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
9861	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
9862	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
9863	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
9864	receptor for angiotensin ii. mediates its action by association with g proteins that activate a phosphatidylinositol- calcium second messenger system.
9865	
9866	necessary for the splicing of pre-mrna. it is required for formation of the earliest atp-dependent splicing complex and interacts with spliceosomal components bound to both the 5@#$%& and 3@#$%& splice sites during spliceosome assembly. it also is required for atp-dependent interactions of both u1 and u2 snrnps with pre-mrna (by similarity). can bind to the myelin basic protein (mbp) gene mb3 regulatory region and increase transcription of the mbp promoter in cells derived from the cns.
9867	may play specific roles in sperm maturation or fertilization (by similarity).
9868	
9869	
9870	
9871	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
9872	soluble frizzled-related proteins (sfrps) function as modulators of wnt signaling through direct interaction with wnts. they have a role in regulating cell growth and differentiation in specific cell types. sfrp3/frzb appears to be involved in limb skeletogenesis. antagonist of wnt8 signaling. regulates chondrocyte maturation and long bone development.
9873	
9874	
9875	
9876	
9877	
9878	
9879	may play an important role in lipogenesis.
9880	
9881	
9882	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
9883	
9884	
9885	
9886	camp-dependent and sulfonylurea-sensitive anion transporter. key gatekeeper influencing intracellular cholesterol transport.
9887	
9888	
9889	
9890	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells. cadherin 23 may function as hair bundle organizer perhaps by cross-linking the stereocilia (by similarity).
9891	could have a role in the budding of coatomer-coated and other species of coated vesicles. could bind cargo molecules to collect them into budding vesicles.
9892	
9893	
9894	could have a role in the budding of coatomer-coated and other species of coated vesicles. could bind cargo molecules to collect them into budding vesicles.
9895	may be involved in modulating chromatin formation and contribute to regulation of cell proliferation.
9896	
9897	
9898	atp-binding rna helicase involved in the biogenesis of 60s ribosomal subunits (by similarity).
9899	
9900	
9901	involved in regulation of adherens junction between cells. functions as a guanine nucleotide exchange factor (gef), which activates rap1 small gtpase by exchanging bound gdp for free gtp.
9902	putative neuronal cell surface protein involved in cell- cell-interactions.
9903	
9904	
9905	
9906	produced by activated macrophages, il-1 stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. il-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
9907	
9908	involved in signal transduction through the wnt pathway.
9909	acts on retinol bound on cellular retinol-binding protein (crbp).
9910	e3 ubiquitin ligase protein that mediates monoubiquitination of lys-120 of histone h2b. h2b lys-120 ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone h3 lys-4 and lys- 79 methylation. forms a ubiquitin ligase complex in cooperation with the e2 enzyme ube2e1/ubch6. it thereby plays a central role in histone code and gene regulation. required for transcriptional activation of hox genes.
9911	
9912	
9913	the zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac.
9914	ampk is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-coa carboxylase. also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-coa reductase and hormone- sensitive lipase. this is a regulatory subunit.
9915	catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. key enzyme that regulate the activity state of the bckd complex (by similarity).
9916	
9917	
9918	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
9919	orphan receptor.
9920	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
9921	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
9922	
9923	
9924	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
9925	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
9926	
9927	
9928	functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. upon ligand activation through the released notch intracellular domain (nicd) it forms a transcriptional activator complex with rbp-j kappa and activates genes of the enhancer of split locus. affects the implementation of differentiation, proliferation and apoptotic programs. may regulate branching morphogenesis in the developing vascular system (by similarity).
9929	integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. it recognizes the sequence r-g-d in its ligands.
9930	
9931	probably function in adherens junction. affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons.
9932	
9933	involved in the association of mhc class i with transporter associated with antigen processing (tap) and in the assembly of mhc class i with peptide (peptide loading).
9934	
9935	
9936	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1d gives rise to l-type calcium currents. long-lasting (l-type) calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group. they are blocked by dihydropyridines (dhp), phenylalkylamines, benzothiazepines, and by omega-agatoxin-iiia (omega-aga-iiia). they are however insensitive to omega-conotoxin- gvia (omega-ctx-gvia) and omega-agatoxin-iva (omega-aga-iva).
9937	
9938	
9939	
9940	
9941	
9942	nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity (by similarity).
9943	
9944	transfers the glycosyl residue from udp-glc to the nonreducing end of alpha-1,4-glucan.
9945	core component of nucleosome. nucleosomes wrap and compact dna into chromatin, limiting dna accessibility to the cellular machineries which require dna as a template. histones thereby play a central role in transcription regulation, dna repair, dna replication and chromosomal stability. dna accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodelling.
9946	
9947	
9948	the ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.
9949	
9950	binds to gc box promoters elements and selectively activates mrna synthesis from genes that contain functional recognition sites. can interact with g/c-rich motifs from serotonin receptor promoter.
9951	
9952	regulates exocytosis in mast cells. increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (by similarity).
9953	could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
9954	may be an activator of the jnk/sapk pathway. phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
9955	
9956	
9957	
9958	
9959	
9960	
9961	involved in repair of uv radiation-induced dna damage. catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same dna strand upon exposure to ultraviolet radiation.
9962	
9963	calcium-dependent mitochondrial solute carrier (by similarity).
9964	forms a water-specific channel. implicated in the generation of saliva, tears, and pulmonary secretions.
9965	may participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. transports glutathione conjugates as leukotriene-c4 (ltc4) and n-ethylmaleimide s-glutathione (nem-gs).
9966	
9967	has a beta1,3-n-acetylglucosaminyltransferase activity for type 2 oligosaccharides.
9968	
9969	specific inactivation of trh after its release.
9970	
9971	involved in the association of mhc class i with transporter associated with antigen processing (tap) and in the assembly of mhc class i with peptide (peptide loading).
9972	
9973	
9974	
9975	
9976	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
9977	
9978	
9979	
9980	required for the expression of several liver specific genes. binds to the inverted palindrome 5@#$%&-gttaatnattaac-3@#$%&.
9981	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
9982	promotes the exchange of gdp by gtp. may act as part of a signal transduction system linking the catalytic domains of pam in the lumen of the secretory pathway to cytosolic factors regulating the cytoskeleton and signal transduction pathways.
9983	
9984	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. a ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase c has also been reported. it can bind to at least three additional proteins in a ca(2+)-independent manner; these are neurexins, syntaxin and ap2.
9985	
9986	involved in control of the cell cycle. upon lytic infection of permissive cells, the hsv transactivator protein vp16 associates with hcfc1. binding to hcfc1 activates vp16 for association with the octamer motif-binding protein pou2f1, to form a multiprotein-dna complex responsible for activating transcription of the hsv immediate early genes. also antagonizes transactivation by zbtb17 and gabp2; represses zbtb17 activation of the p15(ink4b) promoter and inhibits its ability to recruit p300. coactivator for egr2 and gabp2. tethers the chromatin modifying set1/ash2 histone h3-k4 methyltrasferase (hmt) and sin3 histone deacetylase (hdac) complexes (involved in the activation and repression of transcription, respectively) together.
9987	
9988	isoform epor-t, missing the cytoplasmic tail, acts as a dominant-negative receptor of epor-mediated signaling.
9989	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. a ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase c has also been reported. it can bind to at least three additional proteins in a ca(2+)-independent manner; these are neurexins, syntaxin and ap2.
9990	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
9991	
9992	involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with mhc class i molecules. also acts as a molecular scaffold for the final stage of mhc class i folding, namely the binding of peptide. nascent mhc class i molecules associate with tap via tapasin. inhibited by the covalent attachment of herpes simplex virus icp47 protein, which blocks the peptide-binding site of tap. inhibited by human cytomegalovirus us6 glycoprotein, which binds to the lumenal side of the tap complex and inhibits peptide translocation by specifically blocking atp-binding to tap1 and prevents the conformational rearrangement of tap induced by peptide binding. inhibited by human adenovirus e3-19k glycoprotein, which binds the tap complex and acts as a tapasin inhibitor, preventing mhc class i/tap association.
9993	high affinity receptor for semaphorins 3c, 3f, vegf-165 and vegf-145 isoforms of vegf, and the plgf-2 isoform of pgf.
9994	
9995	
9996	required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
9997	
9998	
9999	acts as a transcriptional repressor for zinc finger transcription factors egr1 and egr2. isoform 2 lacks repression ability (by similarity).
10000	binds specifically to u7 snrna.
10001	participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. mediates rac1-dependent reorganization of actin filaments. contributes to the activation of pld2 (by similarity).
10002	putative transcription factor.
10003	
10004	
10005	
10006	
10007	
10008	subunit of the splicing factor sf3b required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex. belongs also to the minor u12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mrna intron.
10009	
10010	may play a role in the immune response to viral infection (by similarity).
10011	
10012	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
10013	
10014	muscle contraction.
10015	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
10016	
10017	
10018	probable transcription factor binds to the usf/mltf site and probably recognizes e-box sequences in the heavy-chain immunoglobulin enhancer.
10019	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes (by similarity). plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
10020	may be involved in transcriptional regulation.
10021	
10022	
10023	neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. it causes contraction of smooth muscle.
10024	acts on galnac. also acts as a galactokinase when galactose is present at high concentrations.
10025	
10026	may be involved in several stages of intracellular trafficking (by similarity).
10027	
10028	type i collagen is a member of group i collagen (fibrillar forming collagen).
10029	
10030	
10031	
10032	
10033	probably methylates the guanidino nitrogens of arginyl residues in some proteins. may play a role in transcriptional coactivation.
10034	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. may play an important role in renal tubular function.
10035	important negative regulator in hematopoiesis and immune systems; may be involved in ending inflammatory responses through its inhibitory functions. inhibits endothelial nf-kappa-b signaling through a camp-dependent pathway. inhibits tnf-alpha- induced expression of endothelial adhesion molecules. involved in the control of fat metabolism and insulin sensitivity.
10036	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. rna polymerase i is essentially used to transcribe ribosomal dna units.
10037	associates with cd4 or cd8 and delivers costimulatory signals for the tcr/cd3 pathway.
10038	
10039	
10040	collagen type iv is specific for basement membranes.
10041	required for larval development.
10042	
10043	
10044	
10045	
10046	catalyzes the deimination of arginine residues of proteins. down-regulates histone h3 and h4 arginine methylation, both by preventing arginine methylation by carm1 and hrmt1l2/prmt1 and by converting methylarginine to citrulline.
10047	plays an important role in the regulation of microtubule (mt) dynamics, regulating the density, length distribution and stability of interphase mts. participates in generating polarized mt networks in migrating fibroblasts.
10048	may inhibit both the autophosphorylation of eif2ak2/pkr and the ability of eif2ak2/pkr to catalyze phosphorylation of the eif2a. may inhibit eif2ak3/perk activity (by similarity). co- chaperone of hspa8/hsc70. involved in the unfolded protein response (upr) during er stress. stimulates the atpase activity of hspa8/hsc70.
10049	
10050	
10051	
10052	transcriptional regulator that probably plays an important role in lymphomagenesis.
10053	
10054	has a role in the negative regulation of gluconeogenesis. required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (fbpase).
10055	
10056	
10057	cytokine that binds to tnfrsf6/fas, a receptor that transduces the apoptotic signal into cells. may be involved in cytotoxic t-cell mediated apoptosis and in t-cell development. tnfrsf6/fas-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature t-cells, or both. binding to the decoy receptor tnfrsf6b/dcr3 modulates its effects.
10058	
10059	protein transport. probably involved in vesicular traffic (by similarity).
10060	
10061	
10062	
10063	
10064	
10065	probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. may also participate in functions of the mature nervous system.
10066	promotes apoptosis and activation of nf-kappa-b. required for tnfrsf1a mediated activation of nf-kappa-b.
10067	
10068	
10069	mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons uaa and uag (by similarity).
10070	interacts with zinc finger protein a20/tnfaip3 and inhibits tnf-induced nf-kappa-b-dependent gene expression by interfering with an rip- or traf2-mediated transactivation signal (by similarity). increases cell surface cd4(t4) antigen expression. interacts with hiv-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. may regulate matrix nuclear localization, both nuclear import of pic (preintegration complex) and export of gag polyprotein and viral genomic rna during virion production.
10071	mbp1 binds to the c-myc promoter and acts as a transcriptional repressor. may be a tumor suppressor.
10072	
10073	
10074	
10075	
10076	suppresses neurite outgrowth (by similarity).
10077	not known. binds to the globular @#$%!heads@#$%! of c1q thus inhibiting c1 activation.
10078	
10079	
10080	
10081	
10082	may have a growth inhibitory role.
10083	receptor on natural killer (nk) cells for hla-c alleles. does not inhibit the activity of nk cells.
10084	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
10085	
10086	
10087	
10088	
10089	
10090	
10091	
10092	catalyzes the reduction of 2,5-diketo-d-gluconic acid (25dkg) to 2-keto-l-gulonic acid (2klg). it is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
10093	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release. inhibits both auto-ubiquitination of park2 and ubiquitination of target proteins by park2 (by similarity).
10094	
10095	
10096	
10097	
10098	involved in the control of dna replication.
10099	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
10100	receptor for the tridecapeptide neurotensin. it is associated with g proteins that activate a phosphatidylinositol- calcium second messenger system.
10101	
10102	
10103	
10104	
10105	
10106	
10107	enhances all basic t-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by b-cells. essential both for efficient interaction between t and b-cells and for normal antibody responses to t-cell dependent antigens. does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. prevents the apoptosis of pre- activated t-cells. plays a critical role in cd40-mediated class switching of immunoglobin isotypes (by similarity).
10108	
10109	transcription activator for a number of liver genes such as afp, albumin, tyrosine aminotransferase, pepck, etc. interacts with the cis-acting regulatory regions of these genes.
10110	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
10111	
10112	
10113	mediates camp-dependent signaling triggered by receptor binding to gpcrs. pka activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.
10114	
10115	
10116	
10117	
10118	muscle contraction.
10119	
10120	cell surface proteoglycan that bears heparan sulfate. putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (by similarity).
10121	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
10122	
10123	converts angiotensin i to angiotensin ii by release of the terminal his-leu, this results in an increase of the vasoconstrictor activity of angiotensin. also able to inactivate bradykinin, a potent vasodilator.
10124	
10125	the beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating g protein inhibition and controlling the alpha-1 subunit membrane targeting.
10126	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
10127	binds to the functionally important cef-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin c transcriptional enhancer. may play an important role in the transcriptional program(s) that underlies smooth muscle cell diversity.
10128	
10129	the insulin-like growth factors possess growth-promoting activity. in vitro, they are potent mitogens for cultured cells. igf-ii is influenced by placental lactogen and may play a role in fetal development.
10130	
10131	
10132	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. may catalyze basal processing of intracellular antigens.
10133	
10134	
10135	
10136	
10137	
10138	
10139	reversible hydration of carbon dioxide.
10140	
10141	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
10142	
10143	
10144	
10145	daughterless/achaete-scute complex heterodimers act as transcriptional activators of neural cell fates and are involved in sex determination.
10146	
10147	
10148	collagen type iv is specific for basement membranes.
10149	part of the snapc complex required for the transcription of both rna polymerase ii and iii small-nuclear rna genes. binds to the proximal sequence element (pse), a non-tata-box basal promoter element common to these 2 types of genes. recruits tbp and brf2 to the u6 snrna tata box.
10150	
10151	inhibits activated protein c as well as plasminogen activators.
10152	
10153	
10154	
10155	
10156	
10157	able to inhibit growth in several cell lines (by similarity).
10158	
10159	able to inhibit growth in several cell lines (by similarity).
10160	forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
10161	ligand gated ion channel with relatively high calcium permeability. binding to atp mediates synaptic transmission between neurons and from neurons to smooth muscle. seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of atp, leading to programmed cell death (by similarity).
10162	
10163	catalyzes a dehydrogenation to introduce c5-6 double bond into lathosterol.
10164	orphan nuclear receptor.
10165	receptor for basic fibroblast growth factor. a shorter form of the receptor could be a receptor for fgf1 (afgf).
10166	
10167	
10168	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex. necessary for h(+) conduction (by similarity).
10169	is able to inhibit all four classes of proteinases by a unique @#$%&trapping@#$%& mechanism. this protein has a peptide stretch, called the @#$%&bait region@#$%& which contains specific cleavage sites for different proteinases. when a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. the entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
10170	stimulatory or required for the translocation of secretory proteins across the er membrane.
10171	collagen type iii occurs in most soft connective tissues along with type i collagen.
10172	histones h1 are necessary for the condensation of nucleosome chains into higher order structures.
10173	monokine with inflammatory and chemokinetic properties. binds to ccr1, ccr4 and ccr5. one of the major hiv-suppressive factors produced by cd8+ t-cells. recombinant mip-1-alpha induces a dose-dependent inhibition of different strains of hiv-1, hiv-2, and simian immunodeficiency virus (siv).
10174	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1c gives rise to l-type calcium currents. long-lasting (l-type) calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group. they are blocked by dihydropyridines (dhp), phenylalkylamines, benzothiazepines, and by omega-agatoxin-iiia (omega-aga-iiia). they are however insensitive to omega-conotoxin- gvia (omega-ctx-gvia) and omega-agatoxin-iva (omega-aga-iva). calcium channels containing the alpha-1c subunit play an important role in excitation-contraction coupling in the heart. the various isoforms display marked differences in the sensitivity to dhp compounds.
10175	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1c gives rise to l-type calcium currents. long-lasting (l-type) calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group. they are blocked by dihydropyridines (dhp), phenylalkylamines, benzothiazepines, and by omega-agatoxin-iiia (omega-aga-iiia). they are however insensitive to omega-conotoxin- gvia (omega-ctx-gvia) and omega-agatoxin-iva (omega-aga-iva). calcium channels containing the alpha-1c subunit play an important role in excitation-contraction coupling in the heart. the various isoforms display marked differences in the sensitivity to dhp compounds.
10176	
10177	
10178	likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. may play a role in the differentiation of spermatozoa and oocytes.
10179	
10180	
10181	
10182	involved in the presentation of foreign antigens to the immune system.
10183	
10184	putative transcription activator that may function in lymphoid development and oncogenesis. binds, in vitro, to double- stranded dna.
10185	involved in vitamin d-mediated transcription. can function as a splicing factor in pre-mrna splicing.
10186	general protein kinase capable of phosphorylating several known proteins.
10187	essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. required for vascular development and regulation of angiogenesis, possibly through a vegf signaling pathway. plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (shh) induction in the limb bud. is involved in the development of branchial arches, which give rise to unique structures in the head and neck. binds dna on e-box consensus sequence 5@#$%&-canntg-3@#$%& (by similarity).
10188	type i collagen is a member of group i collagen (fibrillar forming collagen).
10189	component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix.
10190	
10191	
10192	essential component of the tim23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
10193	essential component of the tim23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
10194	
10195	
10196	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
10197	
10198	
10199	serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors creb (camp response element-binding protein) and atf1 (activating transcription factor-1). essential role in the control of rela transcriptional activity in response to tnf. directly represses transcription via phosphorylation of ser-1 of histone h2a. mediates the mitogen- and stress-induced phosphorylation of histone h3 and high mobility group protein 14 (hmg-14).
10200	may be involved in pre-mrna splicing.
10201	type i collagen is a member of group i collagen (fibrillar forming collagen).
10202	
10203	intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate.
10204	kinase that can phosphorylate various inositol polyphosphate such as ins(3,4,5,6)p4 or ins(1,3,4)p3. phosphorylates ins(3,4,5,6)p4 at position 1 to form ins(1,3,4,5,6)p5. this reaction is thought to have regulatory importance, since ins(3,4,5,6)p4 is an inhibitor of plasma membrane ca(2+)-activated cl(-) channels, while ins(1,3,4,5,6)p5 is not. also phosphorylates ins(1,3,4)p3 on o-5 and o-6 to form ins(1,3,4,6)p4, an essential molecule in the hexakisphosphate (insp6) pathway. also acts as an inositol polyphosphate phosphatase that dephosphorylate ins(1,3,4,5)p4 and ins(1,3,4,6)p4 to ins(1,3,4)p3, and ins(1,3,4,5,6)p5 to ins(3,4,5,6)p4. may also act as an isomerase that interconverts the inositol tetraphosphate isomers ins(1,3,4,5)p4 and ins(1,3,4,6)p4 in the presence of adp and magnesium. probably acts as the rate-limiting enzyme of the insp6 pathway. modifies tnf-alpha-induced apoptosis by interfering with the activation of tnfrsf1a-associated death domain.
10205	
10206	participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. also cleaves alpha-2 macroglobulin. may be involved in osteoblast differenciation and/or osteoblast activity in bone (by similarity).
10207	catalyzes the formation of aromatic c18 estrogens from c19 androgens.
10208	induces sprouting in endothelial cells through an autocrine and paracrine action.
10209	
10210	
10211	
10212	not yet known. essential for viability.
10213	
10214	activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (apc/c). during telophase and in the subsequent g1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (d-box) and an additional degradation signal termed the ken box including ase1, cdc20, the b-type cyclins clb2 and clb3, the polo-like kinase cdc5 and hsl1, and recruits them in a c-box-dependent manner to the apc/c for ubiquitination and subsequent proteolysis. required for exit from mitosis, cytokinesis and formation of prereplicative complexes in g1. probably is the target of a bub2-dependent spindle checkpoint pathway.
10215	component of the dendritic ribonucleoprotein particles (rnps) in hippocampal neurons. may play a role in mrna transport.
10216	component of the dendritic ribonucleoprotein particles (rnps) in hippocampal neurons. may play a role in mrna transport.
10217	part of the insoluble cornified cell envelope (ce) of stratified squamous epithelia.
10218	
10219	
10220	
10221	
10222	
10223	plays an important role in the elongation step of protein synthesis.
10224	
10225	
10226	catalyzes the production of gaba.
10227	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
10228	this protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. it may constitute the earliest mammalian endothelial cell lineage marker. probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.
10229	
10230	
10231	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
10232	
10233	contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion.
10234	protection of cells from complement-mediated damage (by similarity).
10235	
10236	
10237	
10238	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (by similarity).
10239	
10240	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (by similarity).
10241	component of the tom (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. together with tom20 and tom22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the tom40 translocation pore.
10242	involved in the replication of mitochondrial dna.
10243	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
10244	
10245	
10246	
10247	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
10248	may be involved in vesicular trafficking and neurotransmitter release (by similarity).
10249	
10250	
10251	
10252	c/ebp is a dna-binding protein that recognizes two different motifs: the ccaat homology common to many promoters and the enhanced core homology common to many enhancers.
10253	may be involved in transcriptional regulation.
10254	
10255	
10256	
10257	
10258	may be involved in peroxisomal proliferation and may regulate peroxisomes division. may mediate binding of coatomer proteins to the peroxisomal membrane.
10259	catalyzes the first committed step in the biosynthesis of complex n-glycans. it controls conversion of high mannose to complex n-glycans; the final hydrolytic step in the n-glycan maturation pathway.
10260	component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. the nua4 complex atpase and helicase activities seem to be, at least in part, contributed by the association of ruvbl1 and ruvbl2 with ep400. nua4 may also play a direct role in dna repair when directly recruited to sites of dna damage. also component of the msin3a complex which acts to repress transcription by deacetylation of nucleosomal histones.
10261	
10262	phosphorylates microtubule-associated protein 2 (map2). may promote entry in the cell cycle.
10263	
10264	
10265	
10266	
10267	
10268	involved in bcr (b-cell antigen receptor)-mediated signaling in b-cells and tcr (t-cell antigen receptor)-mediated t- cell signaling in t-cells. in absence of tcr signaling, may be involved in cd4-mediated inhibition of t-cell activation. couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or mapk activation through the recruitment of plcg2, grb2, grap2, and other signaling molecules.
10269	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
10270	
10271	
10272	
10273	
10274	ppiases accelerate the folding of proteins during protein synthesis.
10275	
10276	polymerase that creates the 3@#$%& poly(a) tail of mrna@#$%&s. also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. may acquire specificity through interaction with a cleavage and polyadenylation specificity factor (cpsf) at its c-terminus.
10277	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. has angiogenic inhibitor activity (by similarity). active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture (by similarity).
10278	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. has angiogenic inhibitor activity (by similarity). active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture (by similarity).
10279	
10280	essential for biological clock functions. determines the period length of circadian and ultradian rhythms; an increase in per dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. the biological cycle depends on the rhythmic formation and nuclear localization of the tim-per complex. light induces the degradation of tim, which promotes elimination of per. nuclear activity of the heterodimer coordinatively regulates per and tim transcription through a negative feedback loop. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition.
10281	
10282	cytokine that binds to tnfrsf1a/tnfr1 and tnfrsf1b/tnfbr. it is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. it is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, under certain conditions it can stimulate cell proliferation and induce cell differentiation.
10283	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
10284	
10285	may play an important role in the progression of epithelial malignancies.
10286	
10287	can activate specifically hydrolysis of gtp bound to rac1 and cdc42, but not rala. mediates atp-dependent transport of s-(2,4-dinitrophenyl)-glutathione (dnp-sg) and doxorubicin (dox) and is the major atp-dependent transporter of glutathione conjugates of electrophiles (gs-e) and dox in erythrocytes. can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon.
10288	in addition to its enzymatic role it could play an important role in the yeast cell morphology.
10289	
10290	
10291	plays a role in the inducible expression of genes. regulates hypertonicity-induced cellular accumulation of osmolytes.
10292	activates apoptosis.
10293	
10294	
10295	
10296	possesses rna 5@#$%&-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. binds to rna. may participate in nuclear mrna metabolism.
10297	orphan receptor.
10298	
10299	
10300	
10301	
10302	tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
10303	cooperates with cdc6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate dna replication. binds dna in a sequence-, strand-, and conformation-independent manner. potential oncogene.
10304	
10305	candidate for the putative colorectal tumor suppressor gene located at 5q21.
10306	
10307	
10308	may serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. weakly activates the map kinase pathway.
10309	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
10310	collagen type iii occurs in most soft connective tissues along with type i collagen.
10311	
10312	required for meiotic chromosome synapsis and cell cycle progression. may act as a molecular zipper to bring homologous chromosomes in close apposition. zip1 may encode the transverse filaments of the synaptonemal complex.
10313	the soluble form is chemotactic for t-cells and monocytes, but not for neutrophils. the membrane-bound form promotes adhesion of those leukocytes to endothelial cells. may play a role in regulating leukocyte adhesion and migration processes at the endothelium. binds to cx3cr1.
10314	tgf alpha is a mitogenic polypeptide that is able to bind to the egf receptor and to act synergistically with tgf beta to promote anchorage-independent cell proliferation in soft agar.
10315	collagen type iii occurs in most soft connective tissues along with type i collagen.
10316	
10317	receptor for tnfsf13b/blys/baff and tnfsf13/april. promotes b-cell survival and plays a role in the regulation of humoral immunity. activates nf-kappa-b and jnk.
10318	
10319	
10320	type i collagen is a member of group i collagen (fibrillar forming collagen).
10321	
10322	
10323	seems to play an essential role in cold-induced suppression of cell proliferation.
10324	
10325	promotes the exchange of gsp1/gsp2-bound gdp by gtp. involved in yeast pheromone response pathway and in mrna metabolism. probably involved in the control of nuclear organization.
10326	
10327	could be a growth factor active in the process of wound healing. acts as a mitogen in the lung. may act in a manner similar to fgf-7.
10328	required for the assembly of f-actin structures, such as stress fibers. depends on the rho-rock cascade for its activity. contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation.
10329	
10330	
10331	
10332	
10333	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
10334	
10335	
10336	
10337	
10338	
10339	
10340	
10341	
10342	associates with ikaros at centromeric heterochromatin.
10343	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity).
10344	
10345	communication between transverse-tubules and sarcoplasmic reticulum. contraction of cardiac muscle is triggered by release of calcium ions from sr following depolarization of t- tubules (by similarity).
10346	
10347	may be involved in the intracellular transport of sterols or other lipids. may bind cholesterol or other sterols (by similarity).
10348	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
10349	may be involved in transcriptional regulation.
10350	activates e box-dependent transcription in collaboration with tcf3/e47, but the activity is completely antagonized by the negative regulator of neurogenesis hes1. may play a role in the differentiation of subsets of neural cells by activating e box- dependent transcription (by similarity).
10351	
10352	
10353	
10354	lacks adp-ribosylation enhancing activity (by similarity).
10355	
10356	
10357	
10358	enzyme which catalyzes the acetylation of polyamines. substrate specificity: norspermidine = spermidine >> spermine > n(1)acetylspermine > putrescine. this highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. also involved in the regulation of polyamine transport out of cells.
10359	
10360	
10361	
10362	
10363	protein tyrosine phosphatase which stimulates progression from g1 into s phase during mitosis. promotes tumors. inhibits geranylgeranyl transferase type ii activity by blocking the association between rabggta and rabggtb.
10364	
10365	receptor for gonadotropin releasing hormone (gnrh) that mediate the action of gnrh to stimulate the secretion of the gonadotropic hormones (lh and fsh). this receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system.
10366	gtp-binding component of the eukaryotic elongation factor 1 complex (eef1). in its active gtp-bound form, binds to and delivers aminoacyl-trna to the a-site of ribosomes during protein biosynthesis. in the presence of a correct codon-anticodon match between the aminoacyl-trna and the a-site codon of the ribosome-bound mrna, the ribosome acts as a gtpase activator and the gtp is hydrolyzed. the inactive gdp-bound form leaves the ribosome and must be recycled by its guanine nucleotide exchange factor (gef) (eef1b subcomplex) before binding another molecule of aminoacyl-trna. required for nuclear export of aminoacyl-trnas. may also be involved in translational quality control by targeting cotranslationally damaged proteins to the proteasome. also exhibits actin filament-binding and -bundling activities and is involved in cytoskeleton organization.
10367	
10368	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
10369	
10370	involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as elk-1. phosphorylates eif4ebp1; required for initiation of translation. phosphorylates microtubule-associated protein 2 (map2) (by similarity).
10371	
10372	
10373	
10374	
10375	sodium-independent, high-affinity transport of large neutral amino acids. involved in cellular amino acid uptake.
10376	possibly acts as a transcriptional regulatory factor.
10377	catalyzes the reduction of the delta-24 double bond of sterol intermediates. protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. also protects against amyloid-beta peptide-induced apoptosis.
10378	likely to be involved in the control of the cell cycle during s phase and g2.
10379	
10380	this receptor is controlled by g proteins. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium (by similarity).
10381	
10382	
10383	
10384	catalyzes the covalent attachment of ubiquitin to other proteins.
10385	
10386	
10387	
10388	may be involved in the synthesis of gangliosides gd1c, gt1a, gq1b and gt3 from gd1a, gt1b, gm1b and gd3 respectively.
10389	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
10390	cleaves the glcnac-asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
10391	
10392	muscle contraction.
10393	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
10394	intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate.
10395	probable atp-binding rna helicase involved in pre-mrna splicing.
10396	fibrogenic lymphokine, that stimulates several biological activities related to scarring. stimulates synthesis of extracellular matrix protein like collagen, fibronectin and hyaluronan and fibroblast proliferation. induces chemotaxis of fibroblasts and smooth muscle cells. enhances wound healing and may be involved in accelerating epithelization by acting as direct mitogen and/or a motogen for epithelial cells (by similarity). may play a role in fibrogenesis associated with certain chronic inflammatory diseases.
10397	probable transcriptional factor (by similarity).
10398	
10399	
10400	participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.
10401	participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.
10402	
10403	transcriptional regulator (by similarity).
10404	
10405	
10406	probable component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. may be required to regulate the atp- dependent activity (by similarity).
10407	may play a regulatory role in synaptic vesicle recycling.
10408	
10409	required for protein transport from the er to the golgi complex.
10410	
10411	
10412	may act as a downstream effector of cdc42 in cytoskeletal reorganization. contributes to the actomyosin contractility required for cell invasion, through the regulation of mypt1 and thus mlc2 phosphorylation (by similarity).
10413	receptor for all-trans- and 11-cis-retinal. binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.
10414	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
10415	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
10416	
10417	may play a role in acinar cell metabolism.
10418	may play a role in lipid exchange and transport throughout the body. may participate in reverse cholesterol transport from peripheral cells to the liver (by similarity).
10419	
10420	
10421	part of the signal peptidase complex (spc), exact function is not known.
10422	
10423	may be involved in transcriptional regulation.
10424	
10425	
10426	receptor with an affinity for galactose and fucose. could be involved in endocytosis (by similarity).
10427	
10428	
10429	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
10430	catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (spp), a lipid mediator with both intra- and extracellular functions. also acts on d-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as d,l-threo-dihydrosphingosine, n,n-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
10431	
10432	involved in pre-mrna splicing.
10433	
10434	
10435	this is a membrane-bound, calcium-inhibitable adenylyl cyclase.
10436	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
10437	
10438	
10439	
10440	
10441	collagen type ii is specific for cartilaginous tissues. it is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
10442	probable rho/rac effector that binds to the gtp-bound forms of rho and rac1. it probably binds p21 with a tighter specificity in vivo. dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. plays an important role in the regulation of cytokinesis and the development of the central nervous system.
10443	functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. upon ligand activation through the released notch intracellular domain (nicd) it forms a transcriptional activator complex with rbp-j kappa and activates genes of the enhancer of split locus. affects the implementation of differentiation, proliferation and apoptotic programs (by similarity). may regulate branching morphogenesis in the developing vascular system.
10444	serves as the first electron transfer protein in all the mitochondrial p450 systems. including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-oh-vitamin d3-24 hydroxylation in the kidney, and sterol c-27 hydroxylation in the liver.
10445	may be involved in transcriptional regulation.
10446	transcriptional activator which recognizes variations of the palindromic sequence 5@#$%&-attcccnngggaatt-3@#$%& (by similarity).
10447	
10448	reversible hydration of carbon dioxide.
10449	
10450	rab effector protein acting as linker between gamma- adaptin, rab4a and rab5a. involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. stimulates rabgef1 mediated nucleotide exchange on rab5a.
10451	
10452	
10453	
10454	isoform epor-t, missing the cytoplasmic tail, acts as a dominant-negative receptor of epor-mediated signaling.
10455	addition of nucleotide-activated sugars directly onto the polypeptide through o-glycosidic linkage with the hydroxyl of serine or threonine.
10456	addition of nucleotide-activated sugars directly onto the polypeptide through o-glycosidic linkage with the hydroxyl of serine or threonine.
10457	the alpha-v integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von willebrand factor. they recognize the sequence r-g-d in a wide array of ligands.
10458	
10459	
10460	
10461	
10462	
10463	
10464	
10465	
10466	
10467	may play a role in vesicle trafficking.
10468	catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. key enzyme that regulate the activity state of the bckd complex (by similarity).
10469	
10470	converts angiotensin i to angiotensin ii by release of the terminal his-leu, this results in an increase of the vasoconstrictor activity of angiotensin. also able to inactivate bradykinin, a potent vasodilator.
10471	binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. may prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
10472	
10473	putative odorant receptor.
10474	
10475	secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
10476	involved in signal transduction through the wnt pathway. promotes beta-catenin@#$%&s transcriptional activity (by similarity).
10477	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity). overexpression may be associated with abnormal proliferation in human breast tissue.
10478	
10479	enhances nf-kappa-b, srf and ap1 transactivation.
10480	
10481	component of the anaphase promoting complex/cyclosome (apc/c), a cell cycle-regulated e3 ubiquitin-protein ligase complex that controls progression through mitosis and the g1 phase of the cell cycle. the apc/c is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating e2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26s proteasome. in early mitosis, the apc/c is activated by cdc20 and targets securin pds1, the b-type cyclin clb5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. in late mitosis and in g1, degradation of clb5 allows activation of the apc/c by cdh1, which is needed to destroy cdc20 and the b-type cyclin clb2 to allow exit from mitosis and creating the low cdk state necessary for cytokinesis and for reforming prereplicative complexes in g1 prior to another round of replication.
10482	muscle contraction.
10483	
10484	suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. regulates cell death by controlling the mitochondrial membrane permeability. appears to function in a feedback loop system with caspases. inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1).
10485	may be involved in protein trafficking.
10486	receptor for extracellular adenine nucleotides such as atp and adp. in platelets binding to adp leads to mobilization of intracellular calcium ions via activation of phospholipase c, a change in platelet shape, and probably to platelet aggregation.
10487	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
10488	
10489	may play a role in the regulation of rna biogenesis and/or mitosis. in vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone h1.
10490	
10491	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
10492	weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
10493	
10494	
10495	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
10496	
10497	binds to the caccc box in the beta-globin gene promoter and activates transcription. probably serves as a general switch factor for erythroid development.
10498	
10499	thyroid receptor interacting proteins (trips) specifically interact with the ligand binding domain of the thyroid receptor (tr). trip3 requires the presence of thyroid hormone for its interaction.
10500	rna-dependent atpase activity. suppressor of a mutant defective in 50s ribosomal subunit assembly. probably interacts with 23s ribosomal rna.
10501	
10502	
10503	essental for release from glucose repression. it interacts and has functional relationship to the regulatory protein snf4. interacts also with sip1, sip2 and gal83. could phosphorylates cat8.
10504	
10505	
10506	
10507	putative odorant receptor.
10508	transcriptional repressor involved in developmental processes. probably plays a role in limb pattern formation.
10509	plays a major role in ketone body metabolism.
10510	
10511	
10512	part of the snapc complex required for the transcription of both rna polymerase ii and iii small-nuclear rna genes. binds to the proximal sequence element (pse), a non-tata-box basal promoter element common to these 2 types of genes. recruits tbp and brf2 to the u6 snrna tata box.
10513	
10514	may regulate the transcription of specific genes during normal development. may play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. implicated in the transduction of shh signal (by similarity).
10515	
10516	could regulate export of the bud site and axial growth sites selection protein axl2 and possibly other secretory proteins from the endoplasmic reticulum in copii-coated vesicles. seems to be required for axial budding pattern in haploid cells.
10517	required for protein transport from the er to the golgi complex.
10518	binds to membranes enriched in phosphatidylinositol-4,5- biphosphate (ptdins(4,5)p2). modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (by similarity). regulates receptor-mediated endocytosis.
10519	
10520	muscle contraction.
10521	
10522	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
10523	
10524	
10525	
10526	probable glycosyltransferase (by similarity).
10527	
10528	
10529	
10530	binds dna through the consensus sequence 5@#$%&-caatg-3@#$%&. may be involved in transcriptional regulation and may play a role in tooth formation (by similarity).
10531	self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
10532	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
10533	
10534	phosphorylates mkk3 (by similarity). activates the p38 map kinase pathway through the specific activation of the upstream mkk3 kinase.
10535	
10536	
10537	essential for recycling gmp and indirectly, cgmp.
10538	
10539	
10540	transcriptional activator. binds to the consensus sequence 5@#$%&-agatag-3@#$%&. acts as a transcriptional activator of anf in cooperation with nkx2-5 (by similarity).
10541	melanocyte differentiation antigen. may transport substances required for melanin biosynthesis (by similarity).
10542	may play a role in intracellular transport of gaba(a) receptors and its interaction with the cytoskeleton (by similarity).
10543	
10544	chaperone that expresses an atpase activity.
10545	catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.
10546	transcription activator that binds dna cooperatively with dp proteins through the e2 recognition site, 5@#$%&-tttc[cg]cgc- 3@#$%& found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the drtf1/e2f complex functions in the control of cell-cycle progression from g1 to s phase. e2f-3 binds specifically to rb1 protein, in a cell-cycle dependent manner.
10547	acts as a scavenger receptor on macrophages, which specifically binds to oxldl (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (by similarity). induces a strong chemotactic response. induces calcium mobilization. binds to cxcr6/bonzo.
10548	
10549	collagen type iv is specific for basement membranes.
10550	functions in post-golgi recycling pathways. acts as a recycling carrier to the cell surface.
10551	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
10552	
10553	
10554	integrin alpha-v/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von willebrand factor. integrin alpha-iib/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. integrins alpha-iib/beta-3 and alpha-v/beta-3 recognize the sequence r-g-d in a wide array of ligands. integrin alpha-iib/beta-3 recognizes the sequence h-h-l-g-g-g-a-k-q-a-g-d-v in fibrinogen gamma chain. following activation integrin alpha- iib/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. this step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
10555	receptor for members of the ephrin-a family. binds to ephrin-a1, -a2, -a3, -a4 and -a5.
10556	may be involved in protein trafficking from the plasma membrane to the early endosome (ee) as well as in homotypic fusion of endocytic organelles. mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.
10557	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
10558	
10559	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
10560	
10561	
10562	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
10563	
10564	
10565	may be involved in transcriptional regulation.
10566	muscle contraction.
10567	inhibitory regulator of the ras-cyclic amp pathway. binds inositol tetrakisphosphate (ip4) with high affinity. might be a specific ip4 receptor.
10568	ligand for members of the frizzled family of seven transmembrane receptors. wnt-3 and wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
10569	
10570	component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase. required for axial elements (ae) in meiotic cells and for assembly of the synaptonemal complex. may be important for testis development and male fertility.
10571	transcriptional regulator that acts as repressor or activator. binds, in-vitro, to nf-e2 binding sites. play important roles in coordinating transcription activation and repression by mafk.
10572	orphan receptor. possible candidate for amine-like g- protein coupled receptor (by similarity).
10573	
10574	has antibacterial activity (potential).
10575	
10576	
10577	
10578	
10579	
10580	
10581	adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. may link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
10582	
10583	involved in the second step of gpi biosynthesis. de-n- acetylation of n-acetylglucosaminyl-phosphatidylinositol.
10584	
10585	
10586	
10587	the h4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
10588	involved in iron cellular uptake. seems to be internalized and then recycled back to the cell membrane. binds a single atom of iron per subunit. could also bind zinc.
10589	hydrolyzes adenosine 5@#$%&-monophosphoramidate substrates such as amp-morpholidate, amp-n-alanine methyl ester, amp-alpha- acetyl lysine methyl ester and amp-nh2 (by similarity).
10590	
10591	
10592	
10593	
10594	
10595	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
10596	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. anchors xpb.
10597	
10598	
10599	receptor for acth. this receptor is mediated by g proteins (g(s)) which activate adenylate cyclase.
10600	
10601	may act as a lysosomal receptor.
10602	
10603	
10604	non-essential protein which is required for efficient n- glycosylation. necessary for maintaining optimal levels of dolichol-linked oligosaccharides. hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. does not act on phosphatidate.
10605	
10606	collagen type iv is specific for basement membranes.
10607	udpgts are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. this isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). it is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
10608	
10609	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. linked to the keratinization of epithelial tissues.
10610	sequence-specific dna-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. ap-2 factors bind to the consensus sequence 5@#$%&-gccnnnggc-3@#$%& and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. they also suppress a number of genes including mcam/muc18, c/ebp alpha and myc. ap-2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
10611	
10612	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
10613	
10614	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
10615	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
10616	
10617	
10618	
10619	
10620	
10621	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. n-cadherin may be involved in neuronal recognition mechanism.
10622	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
10623	favors the reduction of estrogens and androgens. also has 20-alpha-hsd activity. uses preferentially nadh.
10624	involved in the presentation of foreign antigens to the immune system.
10625	
10626	initiates the extrinsic pathway of blood coagulation. serine protease that circulates in the blood in a zymogen form. factor vii is converted to factor viia by factor xa, factor xiia, factor ixa, or thrombin by minor proteolysis. in the presence of tissue factor and calcium ions, factor viia then converts factor x to factor xa by limited proteolysis. factor viia will also convert factor ix to factor ixa in the presence of tissue factor and calcium (by similarity).
10627	specialized low-affinity urea transporter. mediates urea transport in erythrocytes.
10628	may play a fundamental role in early development of cns. may regulate gene expression and development of postmitotic undifferentiated young neurons.
10629	may function as a gtpase-activating protein.
10630	
10631	catalyzes the reduction of 3-ketodihydrosphingosine (kds) to dihydrosphingosine (dhs).
10632	potential iron transporter (by similarity).
10633	putative adhesion molecule that mediates sialic-acid dependent binding to cells. preferentially binds to alpha2,3 and alpha2,6-linked sialic acid. also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl galnac lactotetraoslylceramide). the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. in the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their sh2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. mediates inhibition of natural killer cells cytotoxicity. may play a role in hemopoiesis. inhibits differentiation of cd34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
10634	
10635	
10636	
10637	involved in repair of uv radiation-induced dna damage. catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same dna strand upon exposure to ultraviolet radiation.
10638	this is one of the five types (d1 to d5) of receptors for dopamine. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
10639	necessary for early peroxisomal biogenesis. acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (pmps). binds and stabilizes newly synthesized pmps in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein pex3. excludes cdkn2a from the nucleus and prevents its interaction with mdm2, which results in active degradation of tp53.
10640	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
10641	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
10642	
10643	not known.
10644	protein transport. probably involved in vesicular traffic (by similarity).
10645	
10646	
10647	
10648	could have a part in mechanisms of transcriptional regulation similar to that played by yeast hir1 and hir2 together.
10649	unknown. antigen recognized on a melanoma by autologous cytolytic t-lymphocytes.
10650	involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. may play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. low-affinity receptor for agouti (by similarity). has a critical role in normal myelination in the central nervous system (by similarity).
10651	
10652	
10653	major high molecular weight protein of desmosomes. involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
10654	may be involved in transcriptional regulation.
10655	performs the first committed step in the biosynthesis of isoprenes.
10656	
10657	hydrolyzes an epoxide moiety of leukotriene a4 (lta-4) to form leukotriene b4 (ltb-4). the enzyme also has some peptidase activity.
10658	binds avidly to the au-rich element in fos and il3/interleukin-3 mrnas. in the case of the fos au-rich element, hur binds to a core element of 27 nucleotides that contain auuua, auuuua, and auuuuua motifs.
10659	in adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
10660	
10661	regulator of vesicular trafficking process. required for the sorting of endocytic (egf receptors) cargos. also involved in exocytic cargos of viral proteins of hiv-1 virus. in case of infection by hiv-1 virus, it is recruited to and functions at sites of viral gag assembly and budding. may be involved in cell growth and differentiation. acts as a negative growth regulator.
10662	
10663	
10664	
10665	
10666	may be involved in transcriptional regulation as a repressor. candidate gene for wolf-hirschhorn (4p-) syndrome (whs).
10667	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. this subunit binds to the 18s rrna.
10668	histone h4, along with histone h3, plays a central role in nucleosome formation.
10669	
10670	
10671	receptor for extracellular adenine nucleotides such as atp and adp. in platelets binding to adp leads to mobilization of intracellular calcium ions via activation of phospholipase c, a change in platelet shape, and probably to platelet aggregation.
10672	
10673	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (by similarity).
10674	
10675	
10676	
10677	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
10678	
10679	
10680	involved in the transduction of mitogenic signals from the cell membrane to the nucleus. may play a role in the postsynaptic responses of hippocampal neuron.
10681	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
10682	might act as an inhibitor of spontaneous calcium carbonate precipitation. may be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
10683	hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. does not have reverse activity.
10684	
10685	
10686	segment polarity protein, functions together with arm to transduce the wingless (wg) signal. acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
10687	couples tyrosine kinase signals with the activation of the rho/rac gtpases, thus leading to cell differentiation and/or proliferation.
10688	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
10689	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
10690	
10691	required for the accumulation of coenzyme a in the mitochondrial matrix.
10692	
10693	low affinity receptor which can bind to ngf, bdnf, nt-3, and nt-4. can mediate cell survival as well as cell death of neural cells.
10694	
10695	
10696	
10697	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
10698	
10699	
10700	since they lack a putative transactivation domain, the small mafs behave as transcriptional repressors when they dimerize among themselves. however, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific dna-binding sites. small maf proteins heterodimerize with fos and may act as competitive repressors of the nf-e2 transcription factor. transcription factor, component of erythroid-specific transcription factor nf- e2. activates globin gene expression when associated with nf-e2.
10701	type i collagen is a member of group i collagen (fibrillar forming collagen).
10702	
10703	
10704	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
10705	promotes the exchange of ras-bound gdp by gtp.
10706	ca(2+)-regulated actin-binding protein.
10707	
10708	
10709	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
10710	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
10711	necessary for the catabolism of n-linked carbohydrates released during glycoprotein turnover. cleaves all known types of alpha-mannosidic linkages.
10712	
10713	acts late in the splicing of pre-mrna. mediates the release of the spliced mrna from spliceosomes.
10714	may be involved in transcriptional regulation.
10715	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
10716	
10717	
10718	
10719	receptor for tnfsf11/rankl/trance/opgl; essential for rankl-mediated osteoclastogenesis. involved in the regulation of interactions between t-cells and dendritic cells.
10720	this protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate (by similarity).
10721	may catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. specific for amino acid residues with aromatic side chains in the p1 position. scce cleaves insulin b chain at 6-leu-|-cys-7, 16-tyr-|-leu-17, 25- phe-|-tyr-26, and 26-tyr-|-thr-27. could play a role in the activation of precursors to inflammatory cytokines.
10722	may be a sfc-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear sr protein (non-snrnp splicing factors containing a serine/arginine-rich domain) trafficking and pre-mrna processing.
10723	
10724	
10725	sequence specific transcriptional activator which binds to the pu-box, a purine-rich dna sequence (5@#$%&-gaggaa-3@#$%&) that can act as a lymphoid-specific enhancer. promotes development of plasmacytoid dendritic cells (pdcs), also known as type 2 dc precursors (pre-dc2) or natural interferon (ifn)-producing cells. these cells have the capacity to produce large amounts of interferon and block viral replication. may be required for b-cell receptor (bcr) signaling, which is necessary for normal b-cell development and antigenic stimulation.
10726	
10727	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
10728	
10729	
10730	
10731	
10732	methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (may methylate hnrnpa1 and histones). methylates supt5h.
10733	
10734	
10735	
10736	possesses single-stranded dna-stimulated atpase and atp- dependent dna helicase (5@#$%& to 3@#$%&) activity. component of the nua4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. the nua4 complex atpase and helicase activities seem to be, at least in part, contributed by the association of ruvbl1 and ruvbl2 with ep400. nua4 may also play a direct role in dna repair when recruited to sites of dna damage. ruvbl2 plays an essential role in oncogenic transformation by myc and also modulates transcriptional activation by the lef1/tcf1 -ctnnb1 complex. may also inhibit the transcriptional activity of atf2.
10737	this protein seals, during dna replication, dna recombination and dna repair, nicks in double-stranded dna.
10738	
10739	
10740	
10741	
10742	
10743	component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase. required for axial elements (ae) in meiotic cells and for assembly of the synaptonemal complex. may be important for testis development and male fertility.
10744	
10745	inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin a. could play a role during central nervous system development (by similarity).
10746	
10747	promotes the exchange of ras-bound gdp by gtp.
10748	
10749	
10750	transcriptional activator which recognizes variations of the palindromic sequence 5@#$%&-attcccnngggaatt-3@#$%& (by similarity).
10751	
10752	
10753	may play a role in organizing the actin cytoskeleton of the brain cells.
10754	may be involved in transcriptional regulation.
10755	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
10756	
10757	type i collagen is a member of group i collagen (fibrillar forming collagen).
10758	
10759	
10760	fabp are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-coa esters. fabp2 is probably involved in triglyceride-rich lipoprotein synthesis. binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. fabp2 may also help maintain energy homeostasis by functioning as a lipid sensor.
10761	the association of the dr1/drap1 heterodimer with tbp results in a functional repression of both activated and basal transcription of class ii genes. this interaction precludes the formation of a transcription-competent complex by inhibiting the association of tfiia and/or tfiib with tbp. can bind to dna on its own.
10762	
10763	
10764	
10765	
10766	
10767	calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. receptor propably implicated in the regulation of exocytosis (by similarity).
10768	
10769	
10770	
10771	
10772	binds calmodulin in a calcium dependent manner. may function as scaffolding or signaling protein.
10773	
10774	
10775	
10776	
10777	
10778	
10779	
10780	probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. has been experimentally shown to be able to bind zinc.
10781	
10782	may play a role in macrophage activation and function.
10783	this is a receptor for glucagon-like peptide 1. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
10784	may function as a transcription factor. seems to repress transcription.
10785	
10786	essential for the wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with frizzled for wnt. specific high-affinity receptor for dkk1 and dkk2, but not dkk3. the interaction with dkk1 blocks lrp6-mediated wnt/beta catenin signaling via lrp6 removal via kremen proteins-mediated endocytosis.
10787	receptor for both mineralocorticoids (mc) such as aldosterone and glucocorticoids (gc) such as corticosterone or cortisol. binds to mineralocorticoid response elements (mre) and transactivates target genes. the effect of mc is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
10788	functions as a component of the nuclear pore complex (npc). npc components, collectively referred to as nucleoporins (nups), can play the role of both npc structural components and of docking or interaction partners for transiently associated nuclear transport factors. active directional transport is assured by both, a phe-gly (fg) repeat affinity gradient for these transport factors across the npc and a transport cofactor concentration gradient across the nuclear envelope (gsp1 and gsp2 gtpases associated predominantly with gtp in the nucleus, with gdp in the cytoplasm). nup116 plays an important role in several nuclear export and import pathways including poly(a)+ rna, trna, preribosome, and protein transport.
10789	
10790	
10791	may be implicated in endosomal trafficking, or microtubule dynamics, or both.
10792	tumor-associated antigen.
10793	
10794	
10795	may function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction (by similarity).
10796	rna-binding protein that plays an essential role in spermatogenesis. may act by binding to the 3@#$%&utr of mrnas and regulating their translation.
10797	
10798	
10799	
10800	
10801	
10802	
10803	plays a role in hyaluronan/hyaluronic acid (ha) synthesis.
10804	
10805	
10806	may be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates.
10807	
10808	may have a role in promoting cell migration (motogen).
10809	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
10810	
10811	has no ppiase/rotamase activity.
10812	acts as a negative coregulator for lim homeodomain transcription factors. via the recruitment of the sin3a/histone deacetylase corepressor complex.
10813	
10814	
10815	
10816	
10817	may function in the secretion of milk-fat droplets. may act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (by similarity).
10818	
10819	may play a role in the regulation of plasmin-mediated matrix remodeling. inhibits trypsin, plasmin, factor viia/tissue factor and weakly factor xa. has no effect on thrombin.
10820	transcription factor that binds gc and gt boxes in the d1a, d2 and d3 dopamine receptor promoters and displaces sp1 and sp3 from these sequences. it modulates dopaminergic transmission in the brain by repressing or activating transcription from several different promoters depending on cellular context.
10821	
10822	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. has angiogenic inhibitor activity (by similarity). active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture (by similarity).
10823	
10824	
10825	
10826	dna-binding protein specific to 5@#$%&-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. preferentially binds to the motif (5@#$%&-gggct-3@#$%&). stimulates the transcription of the human neurotropic virus jcv.
10827	high affinity receptor for semaphorins 3c, 3f, vegf-165 and vegf-145 isoforms of vegf, and the plgf-2 isoform of pgf.
10828	
10829	
10830	
10831	receptor for prostaglandin d2 (pgd2). the activity of this receptor is mainly mediated by g(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular camp. a mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate.
10832	it may catalyze the formation of the neuac-alpha-2,3- gal-beta-1,3-galnac- or neuac-alpha-2,3-gal-beta-1,3-glcnac- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. it may be involved in the biosynthesis of the sialyl lewis x determinant.
10833	
10834	promotes guanine-nucleotide exchange on arf1 and arf3. promotes the activation of arf1/arf3 through replacement of gdp with gtp.
10835	targets myosin phosphatase to the actin cytoskeleton. required for the regulation of the actin cytoskeleton by rhoa and rock1. depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. overexpression of mrip as well as its f- actin-binding region leads to disassembly of stress fibers in neuronal cells.
10836	
10837	
10838	
10839	
10840	ubiquitous transcription factor required for a diverse set of processes. it is a component of the ccr4 complex involved in the control of gene expression (by similarity).
10841	
10842	
10843	
10844	
10845	
10846	
10847	transcriptional repressor.
10848	
10849	collagen type iv is specific for basement membranes.
10850	collagen type iv is specific for basement membranes.
10851	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
10852	
10853	
10854	
10855	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.
10856	may be involved in pre-b-cell growth.
10857	
10858	
10859	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
10860	
10861	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
10862	
10863	
10864	this protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
10865	histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a central role in histone code. preferentially demethylates mono- and dimethylated h3 lys-9 residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated h3 lys-9. demethylation of lys residue generates formaldehyde and succinate. involved in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes, resulting in h3 lys-9 demethylation and transcriptional activation.
10866	
10867	
10868	
10869	
10870	
10871	in the nervous system, could hydrolyze atp and other nucleotides to regulate purinergic neurotransmission. hydrolyzes adp only to a marginal extent. the order of activity with different substrates is atp > gtp > ctp = itp > utp >> adp = udp.
10872	histone h4, along with histone h3, plays a central role in nucleosome formation.
10873	
10874	
10875	
10876	protease that regulate the availability of igfs by cleaving igf-binding proteins.
10877	motor for anterograde axonal transport of synaptic vesicle precursors (by similarity).
10878	
10879	
10880	may play an important role in cell growth and/or transcription.
10881	
10882	
10883	
10884	multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. may play an important role in development and differentiation. the function of yy1 as an activator or a repressor is specified by the presence of other proteins. for example it acts as a repressor in absence of adenovirus e1a protein but as an activator in its presence.
10885	
10886	
10887	
10888	
10889	
10890	
10891	catalyzes the initial reaction in o-linked oligosaccharide biosynthesis, the transfer of an n-acetyl-d- galactosamine residue to a serine or threonine residue on the protein receptor. has a broad spectrum of substrates for peptides such as ea2, muc5ac, muc1a, muc1b and muc7.
10892	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
10893	
10894	
10895	this enzyme can be converted from the dehydrogenase form (d) to the oxidase form (o) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups.
10896	
10897	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
10898	nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. involved in the coactivation of different nuclear receptors, such as for steroids (pgr, gr and er), retinoids (rxrs), thyroid hormone (trs) and prostanoids (ppars). also involved in coactivation mediated by stat3, stat5a, stat5b and stat6 transcription factors. displays histone acetyltransferase activity toward h3 and h4; the relevance of such activity remains however unclear. plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. required with ncoa2 to control energy balance between white and brown adipose tissues. required for mediating steroid hormone response. isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
10899	
10900	
10901	implicated in commitment to and/or differentiation of the myocardial lineage. acts as a transcriptional activator of anf in cooperation with gata4 (by similarity).
10902	component of the origin recognition complex (orc) that binds origins of replication. it has a role in both chromosomal replication and mating type transcriptional silencing. binds to the ars consensus sequence (acs) of origins of replication in an atp-dependent manner.
10903	
10904	
10905	
10906	probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. is not an essential protein. involved in substrate recognition in ubiquitin-dependent degradation.
10907	interacts with htr2c and provokes its clustering at the cell surface (by similarity). member of the nmdar signaling complex that may play a role in control of ampar potentiation and synaptic plasticity in excitatory synapses.
10908	centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. may also act as a centrosome maturation factor. may play a role in microtubule nucleation. overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules.
10909	plasma membrane anion exchange protein of wide distribution. mediates at least a part of the cl(-)/hco3(-) exchange in cardiac myocytes. both bae3 and cae3 forms transport cl(-).
10910	binds double-stranded dna. binds dinucleosomes, probably at the linker region between neighboring nucleosomes. plays a role in chromatin remodeling (by similarity). required for the function of some acidic activation domains, which activate transcription from a distant site.
10911	
10912	may be involved in transcriptional regulation.
10913	
10914	divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. macrophage-specific membrane transport function. controls natural resistance to infection with intracellular parasites. pathogen resistance involves sequestration of fe(2+) and mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
10915	stimulates specifically the gtpase activity of ypt6.
10916	
10917	
10918	
10919	may be involved in cell-adhesion. may function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (by similarity).
10920	may be involved in transcriptional regulation.
10921	seems to be involved in the cross-linking of microtubules and microfilaments.
10922	associates with the t-cell antigen receptor zeta chain (cd3z). plays a role in lymphocyte activation.
10923	
10924	
10925	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
10926	
10927	
10928	
10929	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction. interacts with beta-1 and beta-2, but not with beta-3.
10930	required for pre-mrna splicing. can also modulate alternative splicing in vitro.
10931	
10932	involved in axonal outgrowth and fasciculation (by similarity).
10933	may play a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. there are four molecules of fkbp12 per skeletal muscle ryr. ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
10934	
10935	may play a role in the apoptotic pathway or cell-cycle regulation induced by p53 after dna damage.
10936	may play a role in the apoptotic pathway or cell-cycle regulation induced by p53 after dna damage.
10937	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
10938	
10939	
10940	seems to act as an ig mutase which is responsible for immunoglobulin (ig) gene hypermutation.
10941	
10942	
10943	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. receptor for tgf-beta.
10944	
10945	putative odorant receptor.
10946	has a beta1,3-n-acetylglucosaminyltransferase activity for type 2 oligosaccharides.
10947	may be involved in transcriptional regulation.
10948	catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine.
10949	
10950	adapter involved in the tlr4 signaling pathway in the innate immune response. acts via irak2 and traf-6, leading to the activation of nf-kappa-b, mapk1, mapk3 and jnk, resulting in cytokine secretion and the inflammatory response.
10951	
10952	
10953	receptor with an affinity for galactose and fucose. could be involved in endocytosis.
10954	regulator of egfr mediated signal transduction.
10955	
10956	
10957	binds to nfat-like motifs (purine-rich) in the hiv-1 long terminal repeat and in the il-2 promoter. may be involved in both positive and negative regulation of important viral and cellular promoter elements.
10958	
10959	serine protease that shows proteolytic activity against a nonspecific substrate beta-casein. promotes or induces cell death either by direct binding to and inhibition of birc proteins (also called inhibitor of apoptosis proteins, iaps), leading to an increase in caspase activity, or by a birc inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. isoform 2 seems to be proteolytically inactive.
10960	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. interacts specifically with wnt5a to induce the beta- catenin pathway.
10961	
10962	
10963	
10964	enzyme with a broad specificity. dephosphorylates cdk2 and cdk6 in vitro.
10965	
10966	the reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of dna to another.
10967	possible architectural role during spermatogenesis. may be involved in spermatid differentiation.
10968	
10969	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. interacts with receptor-regulated smads specific for the bmp pathway, smad1 and smad5, in order to trigger their ubiquitination and degradation and hence their inactivation.
10970	microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. most probably involved in vesicular trafficking processes, in particular endocytosis.
10971	component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton.
10972	
10973	may participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or glut4 trafficking.
10974	
10975	
10976	
10977	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
10978	
10979	
10980	
10981	
10982	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
10983	
10984	
10985	binds to the promoter regions of proteolipid proteins of the central nervous system. may play a role in the development of neurons and oligodendrogalia in the cns. may regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.
10986	required for genome wide de novo methylation and is essential for development. it modifies dna in a non-processive manner and also methylates non-cpg sites. acts as a transcriptional corepressor for znf238. can actively repress transcription through the recruitment of hdac activity.
10987	implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. may be involved in the regulation of perinuclear intravesicular membrane traffic (by similarity).
10988	
10989	
10990	
10991	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis (by similarity).
10992	receptor for calcitonin-gene-related peptide (cgrp) together with ramp1 and receptor for adrenomedullin together with ramp2 or ramp3 (by similarity). the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
10993	
10994	complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. may form part of a tissue- specific acute response to remodeling stimuli. known to act on mmp-1, mmp-2, mmp-3, mmp-7, mmp-9, mmp-13, mmp-14 and mmp-15.
10995	
10996	
10997	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
10998	receptor for interleukin-12. involved in il12 transduction. binds to il12 with a low affinity.
10999	
11000	
11001	
11002	putative odorant receptor. could also be involved in taste perception.
11003	
11004	
11005	
11006	
11007	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
11008	
11009	may mediate accelerated atp-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
11010	
11011	actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
11012	
11013	
11014	
11015	may play a role in the er-associated degradation of misfolded glycoproteins.
11016	
11017	
11018	cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the glc(2)man(9)glcnac(2) oligosaccharide precursor of immature glycoproteins.
11019	
11020	
11021	
11022	catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine.
11023	catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine.
11024	
11025	
11026	
11027	involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-coa to the tricarboxylic acid cycle. mcm has different functions in other species.
11028	
11029	
11030	might act as an inhibitor of spontaneous calcium carbonate precipitation.
11031	
11032	
11033	
11034	
11035	
11036	
11037	
11038	
11039	this protein is a @#$%!fusion@#$%! protein encoding four enzymatic activities of the pyrimidine pathway (gatase, cpsase, atcase and dhoase).
11040	collagen type iv is specific for basement membranes.
11041	involved in tethering the chromosomes to the spindle pole and in chromosome movement. microtubule-based anterograde translocator for membranous organelles. plus end-directed microtubule sliding activity in vitro (by similarity).
11042	
11043	
11044	rna-binding protein.
11045	arm and abl proteins function cooperatively at adherens junctions in both the cns and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone@#$%&s response to midline cues. the ability of pcc/mp2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both slit/robo and abl-dependent signaling pathways.
11046	one of the essential components for the initiation of protein synthesis. protects formylmethionyl-trna from spontaneous hydrolysis and promotes its binding to the 30s ribosomal subunits. also involved in the hydrolysis of gtp during the formation of the 70s ribosomal complex.
11047	mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (nes) and of rnas. in the nucleus, in association with ranbp3, binds cooperatively to the nes on its target protein and to the gtpase ran in its active gtp-bound form. docking of this complex to the nuclear pore complex (npc) is mediated through binding to nucleoporins. upon transit of an nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of ran-gtp to ran-gdp (induced by ranbp1 and rangap1, respectively) cause release of the cargo from the export receptor. the directionality of nuclear export is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. also mediates the nuclear export of the rev protein of hiv-1 and rex protein of htlv-1. involved in rex dimerization. involved in u3 snorna transport from cajal bodies to nucleoli. binds to late precursor u3 snorna bearing a tmg cap. several virus, among them hiv-1, htlv-1 and influenza a may use it to export their rna genome out of the nucleus.
11048	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
11049	required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
11050	activates the small gtpases arf1, arf5 and arf6. regulates the formation of post-golgi vesicles and modulates constitutive secretion. modulates phagocytosis mediated by fc gamma receptor and arf6. modulates pxn recruitment to focal contacts and cell migration.
11051	
11052	
11053	transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in ras-dependent proliferation. represses mmp1 promoter activity.
11054	supports the intracellular pip pool and to a lesser extent, the pi 4,5-p(2) pool. it generates pip from pi and, to a lesser extent, pi 4,5-p(2) from pi 4-p. there are indications that it phosphorylates the d-5 rather than the d-4 position. has a role in endosome-related membrane trafficking (by similarity).
11055	probably required for kinetochore function, involved in chromosome segregation during mitosis. interacts with retinoblastoma protein (rb), cenp-e and bubr1.
11056	
11057	
11058	structural component of hyaline cartilage and vitreous of the eye.
11059	
11060	hydrolyzes both cyclic amp (camp) and cyclic gmp (cgmp).
11061	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
11062	
11063	may control phosphatidylinositol concentration in transport vesicles from the subrhabdomeric cisternae (src) to the rhabdomere. may function as a calcium transporter.
11064	
11065	
11066	the muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of g proteins. primary transducing effect is pi turnover.
11067	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
11068	
11069	catalyzes the formation of s-adenosylmethionine from methionine and atp.
11070	
11071	promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. inhibits formation of vascular-like structures. may be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
11072	collagen type ii is specific for cartilaginous tissues. it is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
11073	
11074	appears to function in the signal transduction from ras activation to actin cytoskeletal remodelling. suppresses insulin- induced promoter activities through ap1 and sre. mediates rap1- induced adhesion.
11075	
11076	may play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. could play a role in bone osteoclastic resorption. cleaves kiss1 at a gly-|-leu bond.
11077	
11078	
11079	binds to the metal-regulating-element (mre) of metallothionein-1a gene promoter. binding is zinc-dependent.
11080	
11081	
11082	
11083	
11084	synthesis and degradation of fructose 2,6-bisphosphate.
11085	
11086	
11087	
11088	this protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (gpi-anchor) thus releasing these proteins from the membrane.
11089	
11090	
11091	
11092	
11093	acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin g. may prevent elastase-mediated damage to oral and possibly other mucosal tissues (by similarity).
11094	exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity.
11095	
11096	
11097	not known.
11098	stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
11099	represses hepatitis b virus (hbv) core promoter activity and transcription of hbv genes and production of hbv virions. binds to the consensus dna sequence: 5@#$%&-ga[gt]an[cg][ag]cc-3@#$%&. might protect cells from apoptosis. might be involved in pre-mrna splicing (by similarity).
11100	
11101	
11102	
11103	
11104	
11105	important role in the capacity of milk to transport calcium phosphate.
11106	
11107	
11108	
11109	
11110	collagen type iii occurs in most soft connective tissues along with type i collagen.
11111	alters ptprf cellular localization and induces ptprf clustering. may regulate the disassembly of focal adhesions. may localize receptor-like tyrosine phosphatases type 2a at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
11112	presents carbohydrate ligands to selectins. also implicated in tumor cell metastasis.
11113	tumor-associated antigen.
11114	involved in pre-mrna splicing. this protein is associated with snrnp u2. it binds stem loop iv of u2 snrna only in presence of the u2a@#$%& protein.
11115	major component of the vertebrate myofibrillar m band. binds myosin, titin, and light meromyosin. this binding is dose dependent.
11116	
11117	probably plays a role in the development of the brain and the sense organs. can bind to the bcd target sequence (bts): 5@#$%&-tctaatccc-3@#$%&.
11118	
11119	interacts specifically with a number of opioid ligands. receptor for neuropeptides b and w, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals.
11120	the 26s protease is involved in the atp-dependent degradation of ubiquitinated proteins. the regulatory (or atpase) complex confers atp dependency and substrate specificity to the 26s complex (by similarity).
11121	selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
11122	
11123	
11124	
11125	
11126	
11127	
11128	may be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. may play a role in cell migration.
11129	may control phosphatidylinositol concentration in transport vesicles from the subrhabdomeric cisternae (src) to the rhabdomere. may function as a calcium transporter.
11130	has an effect on position-effect variegation.
11131	
11132	
11133	
11134	
11135	may act at junctions between the membrane and the cytoskeleton.
11136	can repress hiv-1 transcription by binding to the hiv-1 long terminal repeat. involved in the regulation of cftr splicing. it promotes cftr exon 9 skipping by binding to the ug repeated motifs in the polymorphic region near the 3@#$%& splice site of this exon. the resulting aberrant splicing is associated with pathological features typical of cystic fibrosis.
11137	
11138	
11139	may play a role in transcriptional regulation. in vitro, is associated with a kinase activity toward both rna polymerase ii c-terminal domain and cdk2 (cak).
11140	
11141	
11142	catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine.
11143	circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. oscillates in antiphase to the cycling observed for period (per) and timeless (tim). according to ref.3, reaches peak abundance within several hours of the dark-light transition at zt0 (zeitgeber 0), whereas ref.1 describes bimodal oscillating expression with maximum at zt5 and zt23. clock-cycle heterodimers activate cycling transcription of per and tim by binding to the e- box (3@#$%&-cacgtg-5@#$%&) present in their promoters. once induced, period and timeless block clock@#$%&s ability to transactivate their promoters.
11144	possible transcription factor. specifically binds to the ct/gc-rich region of the interleukin-3 promoter and mediates tax transactivation of il-3.
11145	essential component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. seems to control the nucleotide-dependent binding of mitochondrial hsp70 to substrate proteins.
11146	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
11147	
11148	
11149	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. may play an important role in the destruction of aggrecan in arthritic diseases. may play a role in proteolytic processing mostly during the peri-implantation period.
11150	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation by repressing transcription of myocyte enhancer mef2c. during muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (by similarity).
11151	may constitute a glutathionine peroxidase-like protective system against oxidative stresses (by similarity).
11152	
11153	receptor for interleukin-7.
11154	
11155	cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and nad (by similarity).
11156	
11157	facilitative glucose transporter (by similarity).
11158	nucleolin is the major nucleolar protein of growing eukaryotic cells. it is found associated with intranucleolar chromatin and preribosomal particles. it induces chromatin decondensation by binding to histone h1. it is thought to play a role in pre-rrna transcription and ribosome assembly.
11159	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
11160	
11161	
11162	protein transport. probably involved in regulated exocytosis (by similarity).
11163	
11164	major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
11165	
11166	may be involved in several stages of intracellular trafficking. could play an important role in the regulation of glucose transport by insulin. may act as a downstream effector of rhoq/tc10 in the regulation of insulin-stimulated glucose transport (by similarity).
11167	protease which specifically processes pro-lysyl oxidase. required for the embryonic development. predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
11168	
11169	
11170	
11171	
11172	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
11173	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
11174	may contribute to the mechanism of contact inhibition of cell growth.
11175	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
11176	
11177	transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. potential role in g2/m cell cycle regulation (by similarity).
11178	
11179	
11180	plays a role in the formation of clathrin-coated invaginations and endocytosis.
11181	
11182	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
11183	probable transcriptional regulator involved in developmental processes. is required for normal development of the pharyngeal arch arteries (by similarity).
11184	
11185	induces the collapse and paralysis of neuronal growth cones. could potentially act as repulsive cues toward specific neuronal populations. binds to neuropilin (by similarity).
11186	
11187	may mediate the transduction of intracellular signals.
11188	may play a role in epithelioid conversion of fibroblasts.
11189	
11190	type i collagen is a member of group i collagen (fibrillar forming collagen).
11191	transcriptional corepressor. may specifically inhibit gene expression when recruited to promoter regions by sequence specific dna-binding proteins such as bcl6 and mllt3. this repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.
11192	
11193	
11194	plays a role in the regulation of ureagenesis by producing variable amounts of n-acetylglutamate (nag), thus modulating carbamoylphosphate synthase i (cpsi) activity.
11195	phosphorylase is an important allosteric enzyme in carbohydrate metabolism. enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. however, all known phosphorylases share catalytic and structural properties.
11196	
11197	
11198	
11199	
11200	
11201	plays a role in the formation of clathrin-coated invaginations and endocytosis.
11202	
11203	implicated in the suppression of cell death. interacts with the bcl-2 and adenovirus e1b 19 kda proteins (by similarity).
11204	probable regulatory protein involved in regulating the response to growth factors.
11205	may mediate translational control and perform an ef3- related function on the ribosome by regulating e2ak4 kinase activity.
11206	primary vitamin b12-binding and transport protein. delivers cobalamin to cells.
11207	
11208	
11209	
11210	
11211	
11212	
11213	
11214	
11215	
11216	
11217	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
11218	regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
11219	
11220	phosphorylates rs domain-containing proteins, such as sfrs1 and sfrs2 on serine residues. role in spliceosome assembly and in mediating the trafficking of splicing factors. appears to mediate hbv core protein phosphorylation which is a prerequisite for pregenomic rna encapsidation into viral capsids.
11221	involved in the transport of proteins between the endosomes and the trans golgi network (by similarity).
11222	
11223	
11224	has a high affinity for both camp and cgmp.
11225	immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. participates also in the recruitment of tyrosine kinase syk.
11226	
11227	
11228	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling. phosphorylates dvl1.
11229	
11230	plays an essential role in cell growth and maintenance of cell morphology.
11231	type i collagen is a member of group i collagen (fibrillar forming collagen).
11232	
11233	
11234	
11235	functions as histone acetyltransferase and regulates transcription via chromatin remodeling. acetylates all four core histones in nucleosomes. histone acetylation gives an epigenetic tag for transcriptional activation. binds to and may be involved in the transforming capacity of the adenovirus e1a protein. mediates camp-gene regulation by binding specifically to phosphorylated creb protein.
11236	
11237	
11238	
11239	microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. most probably involved in vesicular trafficking processes, in particular endocytosis.
11240	
11241	
11242	
11243	transcriptional inhibitor that binds to dna sequence 5@#$%&- cacct-3@#$%& in different promoters (by similarity).
11244	
11245	acrosin is the major protease of mammalian spermatozoa. it is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
11246	visual pigments are the light-absorbing molecules that mediate vision. they consist of an apoprotein, opsin, covalently linked to cis-retinal.
11247	the isoform smdf may play a role in motor and sensory neuron development.
11248	this protein is essential for differentiation. it may play a role in localizing of nanos (a maternal determinant) activity in oocytes. bicd mutations cause nanos mislocalization and thus bicaudal development.
11249	receptor for the cx3c chemokine fractalkine and mediates both its adhesive and migratory functions. acts as coreceptor with cd4 for hiv-1 virus envelope protein (in vitro). isoform 2 and isoform 3 seem to be more potent hiv coreceptors than isoform 1.
11250	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
11251	
11252	
11253	promotes caspase-mediated apoptosis. this proapoptotic activity is mediated predominantly through the activation of caspase 9. may be a component of the inflammasome, a protein complex which also includes nalp2, card8 and casp1 and whose function would be the activation of proinflammatory caspases (by similarity).
11254	histone acetyltransferase which may act as a transcriptional coactivator for runx1 and runx2.
11255	collagen type iii occurs in most soft connective tissues along with type i collagen.
11256	
11257	
11258	
11259	may be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. may also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
11260	reversible hydration of carbon dioxide. its role in saliva is unknown.
11261	
11262	catalyzes the reverse reaction of mono-adp-ribosylation.
11263	transcriptional repressor. mad binds with max to form a sequence-specific dna-binding protein complex which recognizes the core sequence 5@#$%&-cac[ga]tg-3@#$%&. mad thus antagonizes myc transcriptional activity by competing for max.
11264	
11265	transcription termination factor. binds to a 28 bp region within the trna(leu(uur)) gene at a position immediately adjacent to and downstream of the 16s rrna gene, this region comprises a tridecamer sequence critical for directing accurate termination. probably requires one or more components for termination activity.
11266	
11267	involved in early stages of melanosome biogenesis and maturation (by similarity).
11268	
11269	
11270	molecular chaperone; assists the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin (by similarity).
11271	most effectively accelerate the intrinsic gtpase activity of ypt7. it is also active, but to a lesser extent, on ypt31, ypt32 and ypt1. ypt6 and sec4.
11272	involved in early stages of melanosome biogenesis and maturation (by similarity).
11273	
11274	
11275	
11276	
11277	may play a role in germ line formation.
11278	
11279	
11280	
11281	
11282	involved in the presentation of foreign antigens to the immune system.
11283	
11284	
11285	calcium-dependent mitochondrial solute carrier (by similarity).
11286	catalyzes the transfer of sulfate to position 6 of non- reducing n-acetylglucosamine (glcnac) residues within keratan-like structures on n-linked glycans and within mucin-associated glycans that can ultimately serve as l-selectin ligands. l-selectin ligands are present in high endothelial cells (hevs) and play a central role in lymphocyte homing at sites of inflammation. participates in biosynthesis of l-selectin ligand sialyl 6-sulfo lewis x and in lymphocyte homing to peyer patches. has no activity toward o-linked sugars. its substrate specificity may be influenced by its subcellular location. sulfates glcnac residues at terminal, nonreducing ends of oligosaccharide chains.
11287	
11288	
11289	may be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.
11290	regulates transcription in association with tata binding protein (tbp). removes tbp from the tata box in an atp-dependent manner.
11291	induces apoptosis. interacts with viral and cellular anti-apoptosis proteins. can overcome the suppressors bcl-2 and bcl-xl, although high levels of bcl-xl expression will inhibit apoptosis. may function as a tumor suppressor.
11292	collagen type iii occurs in most soft connective tissues along with type i collagen.
11293	appears to be involved in myelination. could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and k(+)-selective (by similarity).
11294	
11295	
11296	
11297	
11298	
11299	transcription activator that binds dna cooperatively with dp proteins through the e2 recognition site, 5@#$%&-tttc[cg]cgc- 3@#$%& found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the drtf1/e2f complex functions in the control of cell-cycle progression from g1 to s phase. e2f-2 binds specifically to rb1 protein, in a cell-cycle dependent manner.
11300	calcium-dependent mitochondrial solute carrier (by similarity).
11301	
11302	
11303	
11304	reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.
11305	
11306	involved in the transport of glutamate across the inner mitochondrial membrane. glutamate is cotransported with h(+).
11307	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
11308	
11309	
11310	
11311	involved in the transduction of mitogenic signals from the cell membrane to the nucleus. part of the ras-dependent signaling pathway from receptors to the nucleus.
11312	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. rna polymerase i is essentially used to transcribe ribosomal dna units.
11313	enzyme with a broad specificity.
11314	
11315	reversible hydration of carbon dioxide. may stimulate the sodium/bicarbonate transporter activity of slc4a4.
11316	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
11317	capable of removing ubiquitin from ubiquitinated proteins; also capable of removing nedd8 from nedd8 conjugates but has no effect on sentrin-1 conjugates.
11318	may play a role in the control of gene expression.
11319	receptor for the cytotoxic ligand trail. lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. may protect cells against trail mediated apoptosis by competing with trail-r1 and r2 for binding to the ligand.
11320	extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. it is directly involved in endoplasmic reticulum-associated degradation (erad) and targets misfolded glycoproteins for degradation in an n-glycan-dependent manner. it lacks mannosidase activity.
11321	collagen type ii is specific for cartilaginous tissues. it is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
11322	
11323	binds to, and destabilizes, ornithine decarboxylase which is then degraded. also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter.
11324	binds to, and destabilizes, ornithine decarboxylase which is then degraded. also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter.
11325	
11326	
11327	
11328	seems to specifically modulate the transactivation activity of wt1.
11329	
11330	
11331	
11332	
11333	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
11334	
11335	
11336	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
11337	receptor for atp that acts as a ligand gated ion channel. responsible for atp-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. could function in both fast synaptic transmission and the atp-mediated lysis of antigen-presenting cells.
11338	
11339	
11340	
11341	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
11342	exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.
11343	
11344	
11345	catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (ipp) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (dmapp) (by similarity).
11346	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
11347	plays a general role in the hierarchies of gene expression leading to metamorphosis.
11348	
11349	protein kinase that act on both serine and threonine residues.
11350	
11351	
11352	
11353	receptor for the hormone galanin. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity.
11354	
11355	
11356	
11357	plays a role in the inducible expression of cytokine genes in t-cells, especially in the induction of the il-2 or il-4 gene transcription. also controls gene expression in embryonic cardiac cells. could regulate not only the activation and proliferation but also the differentiation and programmed death of t-lymphocytes as well as lymphoid and non-lymphoid cells.
11358	
11359	protein transport. probably involved in vesicular traffic (by similarity).
11360	interacts with the cytoplasmic tail of nmda receptor subunits and shaker-type potassium channels. required for synaptic plasticity associated with nmda receptor signaling. overexpression or depletion of dlg4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. may reduce the amplitude of accn3 acid-evoked currents by retaining the channel intracellularly. may regulate the intracellular trafficking of adr1b (by similarity).
11361	seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. seems to demarcate the paranodal region of the axo-glial junction. in association with contactin may have a role in the signaling between axons and myelinating glial cells.
11362	this is an intracellular thiol proteinase inhibitor.
11363	circadian regulator that may act as a transcription factor. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition. expression oscillates with a 24 hour rhythm in the suprachiasmatic nucleus (scn) and the whole eyes. oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. there is a 4 hour time delay between per1 and per2 oscillations. the expression rhythms appear to originate from retina (by similarity).
11364	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
11365	this gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
11366	
11367	
11368	
11369	efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
11370	functions as a histone acetyltransferase (hat) to promote transcriptional activation. has significant histone acetyltransferase activity with core histones (h3 and h4), and also with nucleosome core particles. inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein e1a.
11371	important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. specifically binds to an il-1 response element in the il-6 gene. nf-il6 also binds to regulatory regions of several acute-phase and cytokines genes. it probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. the consensus recognition site is 5@#$%&-t[tg]nngnaa[tg]-3@#$%&.
11372	
11373	
11374	
11375	
11376	this enzyme catalyzes the hydrolysis of the n-terminal peptide bond of an n-acetylated peptide to generate an n- acetylated amino acid and a peptide with a free n-terminus. it preferentially cleaves off ac-ala, ac-met and ac-ser.
11377	may be involved in the regulation of gene expression by covalent modification of histone proteins. the long isoform is a corepressor of estrogen receptor (er). the short isoform binds to er and sequesters it in the cytoplasm and enhances non-genomic responses of er.
11378	
11379	
11380	
11381	
11382	
11383	
11384	
11385	
11386	
11387	
11388	muscle contraction.
11389	
11390	
11391	
11392	
11393	may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes (by similarity).
11394	
11395	
11396	
11397	
11398	
11399	may be involved in transcriptional regulation.
11400	
11401	cell adhesion molecule that binds to cd6. involved in neurite extension by neurons via heterophilic and homophilic interactions. may play a role in the binding of t- and b-cells to activated leukocytes, as well as in interactions between cells of the nervous system.
11402	receptor for a c-c type chemokine. binds to mip-1-alpha, mip-1-beta and rantes and subsequently transduces a signal by increasing the intracellular calcium ions level. may play a role in the control of granulocytic lineage proliferation or differentiation. acts as a coreceptor (cd4 being the primary receptor) for hiv-1 r5 isolates.
11403	stimulates hepatic and intestinal proliferation.
11404	
11405	
11406	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
11407	associated with the mammalian reproductive process. catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
11408	resistance to tetracycline by an active tetracycline efflux. this is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. this protein functions as a metal-tetracycline/h(+) antiporter.
11409	
11410	
11411	may serve as dna-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
11412	
11413	
11414	probable scaffold protein that may be involved in mrna transport (potential).
11415	
11416	
11417	attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to na-k atpase, to the lymphocyte membrane protein gp85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. in skeletal muscle, isoform mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
11418	receptor for neuropeptide y and peptide yy.
11419	
11420	
11421	
11422	
11423	involved in controlling the equilibrium between tubular and stacked structures in the golgi complex (by similarity). co- repressor targeting diverse transcription regulators. has dehydrogenase activity.
11424	involved in controlling the equilibrium between tubular and stacked structures in the golgi complex (by similarity). co- repressor targeting diverse transcription regulators. has dehydrogenase activity.
11425	
11426	transcriptional regulator involved in developmental processes. can activate pomc gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.
11427	may be involved in several stages of intracellular trafficking. act as a gap for galphas.
11428	the h3 subclass of histamine receptors could mediate the histamine signals in cns and peripheral nervous system. signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization.
11429	
11430	
11431	
11432	factor xi triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor ix.
11433	represses transcription by binding to the bte site, a gc-rich dna element, in competition with the activator sp1. it also represses transcription by interacting with the corepressor sin3a and hdac1. activates rantes expression in t-cells.
11434	
11435	
11436	
11437	
11438	
11439	
11440	
11441	may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine.
11442	may be a mediator of localized cell proliferation. as a mitogen it may stimulate cell proliferation and/or angiogenesis.
11443	
11444	probable transcription factor involved in embryogenesis and somatogenesis (by similarity).
11445	
11446	may be involved in transcriptional regulation.
11447	
11448	
11449	
11450	
11451	receptor for atp that acts as a ligand gated ion channel.
11452	
11453	
11454	
11455	
11456	
11457	collagen type iii occurs in most soft connective tissues along with type i collagen.
11458	may be required for testis development.
11459	
11460	plays an important role in the differentiation and development of pancreatic islet beta cells. transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. competes with pax6 for this same promoter binding site. the pax4v isoform appears to be a dominant negative form antagonizing pax4 transcriptional activity.
11461	
11462	may be involved in several stages of intracellular trafficking (by similarity).
11463	
11464	
11465	
11466	
11467	type i collagen is a member of group i collagen (fibrillar forming collagen).
11468	thought to stabilize the calcium channel in an inactivated (closed) state (by similarity).
11469	
11470	
11471	bifunctional enzyme that catalyzes the fourth and fifth sequential steps of coa biosynthetic pathway. the fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coad domain; the fifth reaction is catalyzed by the dephospho-coa kinase, coded by the coae domain. may act as a point of coa biosynthesis regulation.
11472	
11473	thought to form a receptor-activated non-selective calcium permeant cation channel. probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or g-protein coupled receptors. activated by diacylglycerol (dag) in a membrane-delimited fashion, independently of protein kinase c, and by inositol-1,4,5- triphosphate receptors (itpr) with bound ip3. may also be activated by internal calcium store depletion.
11474	
11475	
11476	
11477	
11478	ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. it has ferroxidase activity oxidizing iron(ii) to iron(iii) without releasing radical oxygen species. it is involved in iron transport across the cell membrane.
11479	
11480	stimulates specifically the gtpase activity of ypt6.
11481	this is a receptor for corticotropin releasing factor. shows high-affinity crf binding. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
11482	
11483	
11484	
11485	
11486	hydrolyzes udp-glucose to glucose 1-phosphate and ump and adp-ribose to ribose 5-phosphate and amp. the physiological substrate is probably udp-glucose. poor activity on other substrates such as adp-glucose, cdp-glucose, gdp-glucose and gdp- mannose.
11487	collagen type iii occurs in most soft connective tissues along with type i collagen.
11488	
11489	
11490	
11491	
11492	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
11493	
11494	
11495	
11496	
11497	transcription factor that binds to gc box promoter elements. selectively activates mrna synthesis from genes containing tandem repeats of gc boxes but represses genes with a single gc box.
11498	methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (can methylate hnrnpa1 and histones). methylates supt5h (by similarity).
11499	
11500	regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. the condensin complex probably introduces positive supercoils into relaxed dna in the presence of type i topoisomerases and converts nicked dna into positive knotted forms in the presence of type ii topoisomerases.
11501	anchoring filament protein which is a component of the basement membrane zone. may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. could maintain dermal-epidermal cohesion.
11502	
11503	
11504	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins. probably involved in anxiety and depression.
11505	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
11506	
11507	
11508	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
11509	
11510	interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite dna, called the cenp-b box. may organize arrays of centromere satellite dna into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (by similarity).
11511	
11512	
11513	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. plays an important role in fatty acid metabolism in brain and the acyl-coas produced may be utilized exclusively for the synthesis of the brain lipid.
11514	
11515	may play an accessory role in the regulation of protein biosynthesis.
11516	may function as a phosphatase involved in the regulation of cell growth and differentiation.
11517	
11518	
11519	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
11520	
11521	
11522	
11523	essential for cell viability. taf9 and taf9b are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. may have a role in gene regulation associated with apoptosis. tafs are components of the transcription factor iid (tfiid) complex, the tbp-free tafii complex (tftc), the pcaf histone acetylase complex and the staga transcription coactivator-hat complex. tfiid or tftc are essential for the regulation of rna polymerase ii-mediated transcription.
11524	
11525	
11526	
11527	
11528	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
11529	
11530	
11531	
11532	
11533	
11534	
11535	
11536	tumor suppressor that may be involved in interferon- dependent cell death (by similarity).
11537	may facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery.
11538	has an anti-hypocalcemic action on calcium and phosphate homeostasis.
11539	
11540	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
11541	
11542	
11543	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
11544	implicated in tumor cell metastasis. may function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction.
11545	
11546	
11547	
11548	essential component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. seems to control the nucleotide-dependent binding of mitochondrial hsp70 to substrate proteins.
11549	the cd3 complex mediates signal transduction.
11550	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
11551	probable chloride channel (by similarity).
11552	may be involved in transcriptional regulation.
11553	
11554	
11555	
11556	
11557	
11558	
11559	may be involved in neuronal differentiation.
11560	may be involved in neuronal differentiation.
11561	seems to bind protein kinase c acting as an intracellular receptor to anchor the activated pkc to the cytoskeleton (by similarity).
11562	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potasssium ions may pass in accordance with their electrochemical gradient. may play a role in regulating the secretion of insulin in normal pancreatic islets.
11563	binds the telomeric double-stranded ttaggg repeat. protects against end-to-end fusion of chromosomes and plays a role in successful progression through the cell division cycle.
11564	
11565	
11566	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb.
11567	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
11568	
11569	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis (by similarity).
11570	
11571	
11572	
11573	
11574	this is a probable transcription activator that specifically binds the purine-rich single strand of the pur element located upstream of the myc gene. may play a role in the initiation of dna replication and in recombination.
11575	required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors. may bind a rab gtpase such as vps21.
11576	
11577	
11578	specifically binds to the upstream regulatory region of type i ifn and ifn-inducible mhc class i genes (the interferon consensus sequence (ics)) and activates those genes.
11579	may be involved in transcriptional regulation.
11580	stimulates gtp hydrolysis of members of the rho family. could activates gtpase targets that are known to affect cell migration and outgrowth of axons and dendrites.
11581	
11582	involved in translocation of long-chain fatty acids (lfca) across the plasma membrane. thought to function as the predominant fatty acid protein transporter in heart.
11583	
11584	met- and leu-enkephalins compete with and mimic the effects of opiate drugs. they play a role in a number of physiologic functions, including pain perception and responses to stress.
11585	may have an important role in presynaptic function. may be involved in calcium-dependent neurotransmitter release at nerve endings (by similarity).
11586	
11587	
11588	component of a protein kinase signal transduction cascade. activates the erk and jnk kinase pathways by phosphorylation of map2k1 and map2k4. activates chuk and ikbkb, the central protein kinases of the nf-kappa-b pathway.
11589	
11590	
11591	
11592	
11593	may be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. may play a role in cell migration (by similarity).
11594	class-iv neuronal intermediate filament that is able to self-assemble. it is involved in the morphogenesis of neurons. it may form an independent structural network without the involvement of other neurofilaments or it may cooperate with nf-l to form the filamentous backbone to which nf-m and nf-h attach to form the cross-bridges (by similarity).
11595	
11596	participates in the second step of pre-mrna splicing.
11597	
11598	
11599	
11600	chemotactic factor that attracts skin-associated memory t-lymphocytes. may play a role in mediating homing of lymphocytes to cutaneous sites. binds to ccr10.
11601	may be involved in transcriptional regulation.
11602	probable protein phosphatase (by similarity).
11603	
11604	may be involved in the binding and intracellular trafficking of cobalamin (vitamin b12).
11605	promotes cell survival. blocks dexamethasone-induced apoptosis. mediates survival of postmitotic sertoli cells by suppressing death-promoting activity of bax.
11606	regulates downstream kinases in response to environmental stress. may also have a function in regulating the actin cytoskeleton.
11607	
11608	
11609	
11610	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
11611	serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (dsbs), apoptosis and genotoxic stresses such as ionizing ultraviolet a light (uva), thereby acting as a dna damage sensor. recognizes the substrate consensus sequence [s/t-q]. phosphorylates ser-139 of histone variant h2ax/h2afx at double strand breaks (dsbs), thereby regulating dna damage response mechanism. also involved in signal transduction and cell cycle control. may function as a tumor suppressor. necessary for activation of abl1 and sapk. phosphorylates p53/tp53, fancd2, nfkbia, brca1, ctip, nibrin (nbn), terf1, rad9 and dclre1c. may play a role in vesicle and/or protein transport. could play a role in t-cell development, gonad and neurological function.
11612	may play a role in the assembly of the f1 component of the mitochondrial atp synthase (atpase).
11613	
11614	
11615	terminates the action of gaba by its high affinity sodium-dependent reuptake into presynaptic terminals.
11616	
11617	required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.
11618	may play a role in vesicle trafficking and exocytosis (potential).
11619	binds single-stranded rna. has a high affinity for g- rich and u-rich regions of hnrna. also binds to apob mrna transcripts around the rna editing site.
11620	
11621	non-essential protein involved in fatty acid metabolism.
11622	circadian regulator that acts as a transcription factor. clock-bmal1 heterodimers bind to an e-box element (3@#$%&-cacgtg-5@#$%&), thereby activating transcription of per1, and possibly of other circadian clock proteins. mutant clock and bmal1 form hetereodimers that bind dna, but fail to activate transcription (by similarity).
11623	polymerase that creates the 3@#$%& poly(a) tail of mrna@#$%&s. also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. may acquire specificity through interaction with a cleavage and polyadenylation specificity factor (cpsf) at its c-terminus.
11624	
11625	
11626	
11627	
11628	transcription factor that binds specifically to the distal ras-responsive element (rre) in the calcitonin gene promoter and augment the ras/raf-mediated transcriptional response of that promoter. may be involved in ras/raf-mediated cell differentiation.
11629	
11630	
11631	binds to gtp-bound form of rho and to profilin. acts in a rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. it is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics (by similarity).
11632	
11633	may direct with other members of the subcomplex rna pol iii binding to the tfiiib-dna complex via the interactions between tfiiib and polr3f. may be involved either in the recruitment and stabilization of the subcomplex within rna polymerase iii, or in stimulating catalytic functions of other subunits during initiation.
11634	
11635	the gpib-v-ix complex functions as the von willebrand factor receptor and mediates von willebrand factor-dependent platelet adhesion to blood vessels. the adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis (by similarity).
11636	receptor for somatostatin-14. the activity of this receptor is mediated by g proteins which inhibits adenylyl cyclase. it is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (map) kinase cascade. mediates antiproliferative action of somatostatin in tumor cells.
11637	transcriptional activator that binds to the sterol regulatory element 1 (sre-1) (5@#$%&-atcaccccac-3@#$%&) found in the flanking region of the ldrl and hmg-coa synthase genes.
11638	
11639	plays a role in the notch signaling pathway. activates notch-1 and notch-4 (by similarity).
11640	orphan receptor.
11641	promotes angiogenesis and the proliferation of endothelial cells. able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
11642	
11643	
11644	
11645	may be involved in transcriptional regulation.
11646	probable pseudophosphatase. lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. the pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts.
11647	functions as a histone acetyltransferase (hat) to promote transcriptional activation. acetylation of histones gives a specific tag for epigenetic transcription activation. has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (by similarity).
11648	
11649	receptor for the glial cell line-derived neurotrophic factor, artemin. mediates the artemin-induced autophosphorylation and activation of the ret receptor tyrosine kinase.
11650	receptor for the glial cell line-derived neurotrophic factor, artemin. mediates the artemin-induced autophosphorylation and activation of the ret receptor tyrosine kinase.
11651	could be involved in normal hemopoietic differentiation as well as in erythroid/myeloid lineage switching (by similarity).
11652	
11653	
11654	sodium-ion dependent, high affinity carnitine transporter. involved in the active cellular uptake of carnitine. transports one sodium ion with one molecule of carnitine. also transports organic cations such as tetraethylammonium (tea) without the involvement of sodium. also relative uptake activity ratio of carnitine to tea is 11.3.
11655	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. socs1 is involved in negative regulation of cytokines that signal through the jak/stat3 pathway. through binding to jaks, inhibits their kinase activity. in vitro, also suppresses tec protein- tyrosine activity. appears to be a major regulator of signaling by interleukin 6 (il6) and leukemia inhibitory factor (lif). regulates interferon-gamma mediated sensory neuron survival (by similarity). implicated, through socs box binding, in ubiquitin- dependent protein degradation.
11656	
11657	forms critical branches in o-glycans.
11658	thought to stabilize the calcium channel in an inactivated (closed) state (by similarity).
11659	could function as a cell-adhesion protein. acts as a tumor suppressor. required for correct morphogenesis.
11660	
11661	
11662	
11663	
11664	
11665	
11666	may play a role in tissue-remodeling process occurring in both normal and pathological conditions.
11667	
11668	
11669	required for genome wide de novo methylation and is essential for development.
11670	
11671	
11672	
11673	
11674	
11675	essential for the control of the cell cycle at the late g1 and early s phase.
11676	putative rho/rac effector that binds to the gtp-bound forms of rho and rac1. it probably binds p21 with a tighter specificity in vivo. dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. plays an important role in the regulation of cytokinesis and the development of the central nervous system (by similarity).
11677	may play a role in promoting maturation and morphological differentiation of cerebellar neurons.
11678	may activate nf-kappa-b and jnk and promote apoptosis.
11679	
11680	
11681	
11682	
11683	
11684	possible receptor for triiodothyronine.
11685	
11686	component of a protein kinase signal transduction cascade. activates the csbp2, p38 and jnk mapk pathways, but not the erk pathway. specifically phosphorylates and activates map2k4 and map2k6.
11687	
11688	
11689	required for transport of secretory proteins from the golgi complex. catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. essential for viability and secretion.
11690	
11691	
11692	
11693	collagen type iii occurs in most soft connective tissues along with type i collagen.
11694	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
11695	
11696	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis. regulates the ca(2+)- dependent secretion of norepinephrine in pc12 cells. required for export from the endocytic recycling compartment to the cell surface (by similarity).
11697	
11698	the insulin-like growth factors possess growth-promoting activity. in vitro, they are potent mitogens for cultured cells. igf-ii is influenced by placental lactogen and may play a role in fetal development.
11699	receptor that binds specifically to pdgfb and has a tyrosine-protein kinase activity. phosphorylates tyr residues at the c-terminus of ptpn11 creating a binding site for the sh2 domain of grb2.
11700	may play a role as a mediator of inflammation and angiogenesis.
11701	involved in peroxisome biosynthesis. required for stability of the pts1 receptor. anchored by pex26 to peroxisome membranes, possibly to form heteromeric aaa atpase complexes required for the import of proteins into peroxisomes.
11702	
11703	
11704	
11705	
11706	
11707	
11708	
11709	binds to g-rich structures in 28s rrna and in mrnas. plays a regulatory role in the translation apparatus; inhibits cell-free translation of mrnas.
11710	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
11711	may have a regulatory bifunctional role.
11712	inhibits the transactivation activity of the myod family of myogenic factors and represses myogenesis. acts by associating with myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. can also interfere with the dna-binding activity of myod family members. plays an important role in trophoblast and chondrogenic differentiation (by similarity).
11713	
11714	
11715	important for the resorption of phosphate by the kidney. may be involved in actively transporting phosphate into cells via na(+) cotransport in the renal brush border membrane.
11716	
11717	histone h3, along with histone h4, plays a central role in nucleosome formation.
11718	cross-linked envelope protein of keratinocytes. it is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. all that results in the formation of an insoluble envelope beneath the plasma membrane. can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage.
11719	
11720	
11721	involved in gm1/gd1b/ga1 ganglioside biosynthesis.
11722	
11723	
11724	
11725	type i collagen is a member of group i collagen (fibrillar forming collagen).
11726	probably involved in ubiquitination and subsequent proteasomal degradation of target proteins. plays a role in the polyubiquitination of cdt1 in response to radiation-induced dna damage.
11727	collagen type iii occurs in most soft connective tissues along with type i collagen.
11728	
11729	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
11730	
11731	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. in retina, myosin viia might play a role in trafficking of ribbon- synaptic vesicle complexes and renewal of the outer photoreceptors disks. in inner ear, it might maintain the rigidity of stereocilia during the dynamic movements of the bundle. involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (by similarity).
11732	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
11733	
11734	
11735	
11736	probably involved in lipid transport.
11737	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
11738	the intermediate chains seem to help dynein bind to dynactin 150 kda component. may play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
11739	
11740	
11741	
11742	seems to negatively regulate apoptosis by promoting fadd phosphorylation. enhances androgen receptor-mediated transcription. may act as a transcriptional corepressor for nk homeodomain transcription factors.
11743	derived from proteolytic degradation of complement c4, c4a anaphylatoxin is a mediator of local inflammatory process. it induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
11744	
11745	appears to mediate neuronal differentiation.
11746	acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. one of the activated genes is an inhibitor of cyclin-dependent kinases. apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of bcl-2 expression.
11747	required for perception of chronic pain through nmda receptor signaling. regulates surface expression of nmda receptors in dorsal horn neurons of the spinal cord. interacts with the cytoplasmic tail of nmda receptor subunits as well as inward rectifying potassium channels. involved in regulation of synaptic stability at cholinergic synapses. part of the postsynaptic protein scaffold of excitatory synapses (by similarity).
11748	
11749	
11750	
11751	
11752	
11753	
11754	plays a critical role in catalyzing the release of class ii hla-associated invariant chain-derived peptides (clip) from newly synthesized class ii hla molecules and freeing the peptide binding site for acquisition of antigenic peptides.
11755	
11756	nuclear hormone receptor. involved in the retinoic acid response pathway. binds 9-cis retinoic acid (9c-ra). arf6 acts as a key regulator of the tissue-specific adipocyte p2 (ap2) enhancer (by similarity).
11757	may play an important role in fibrillogenesis by controlling lateral growth of collagen ii fibrils.
11758	component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix.
11759	
11760	
11761	diverse functions during morphogenesis in drosophila. complete loss-of-function mutations lead to late embryonic lethality. certain partial loss-of-function mutations give raise to escaper adults, which have rough eyes associated with changes in cell fate and pattern, misshappen legs and defects in wing structure.
11762	
11763	
11764	transcription factors activated upon intramembrane proteolysis (rip), binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ag][ag]-3@#$%&), a sequence present in many viral and cellular promoters. binds to and requires hcfc1 as a coactivator. activity and expression are suppressed when the hcfc1-creb3 complex binds with zf. participates in lkn-1/ccl15- induced chemotaxis signaling.
11765	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
11766	binds to the basic helix-loop-helix protein tal-1. this interaction seems to be critical for the regulation of red blood cell development.
11767	
11768	required for protein transport from the er to the golgi complex.
11769	transcriptional repressor; binds to the dna sequence 5@#$%&- ccggaagt-3@#$%&. isoform a and isoform c do not seem to have a repressor activity.
11770	
11771	
11772	
11773	transcriptional repressor. binds with max to form a sequence-specific dna-binding protein complex which recognizes the core sequence cac[ga]tg. antagonizes myc transcriptional activity by competing for max (by similarity).
11774	acts as an a-kinase anchoring protein by binding to the type ii regulatory subunit of protein kinase a and anchoring it to the mitochondrion. also involved in synchronization of mitochondrial fission.
11775	
11776	
11777	
11778	
11779	
11780	
11781	
11782	
11783	may play a role in cytoskeletal stability (by similarity).
11784	transcription factor that binds to the octamer motif (5@#$%&-atttgcat-3@#$%&) and activates the promoters of the genes for some small nuclear rnas (snrna) and of genes such as those for histone h2b and immunoglobulins. modulates transcription transactivation by nr3c1, ar and pgr (by similarity).
11785	mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.
11786	required for fusion of er-derived vesicles with the golgi during er-to-golgi protein transport, probably by mediating correct membrane localization of ypt1.
11787	
11788	
11789	it is involved in repression by a1-alpha2 and alpha2 and in other systems as a general repressor of transcription. this protein has no obvious dna-binding domains. it might not interact directly with dna but with dna-bound proteins.
11790	
11791	
11792	
11793	
11794	
11795	probable e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. non essential.
11796	
11797	
11798	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis. regulates the ca(2+)- dependent secretion of norepinephrine in pc12 cells. required for export from the endocytic recycling compartment to the cell surface (by similarity).
11799	this protein is a component of ribonucleosomes. could be needed to organize a concentration gradient of a dorsalizing morphogen (dm) originating in the germinal vesicle. at least one of the isoforms is essential in somatic tissues.
11800	
11801	
11802	
11803	
11804	
11805	
11806	may be involved in several stages of intracellular trafficking.
11807	crystallins are the dominant structural components of the vertebrate eye lens.
11808	
11809	creates a soluble precursor oligosaccharide fuc-alpha ((1,2)galbeta-) called the h antigen which is an essential substrate for the final step in the soluble a and b antigen synthesis pathway. h and se enzymes fucosylate the same acceptor substrates but exhibit different km values.
11810	plays a role in a process governing chromosomal dynamics during mitosis (by similarity).
11811	
11812	
11813	
11814	
11815	
11816	probably required for protein import into peroxisomes. anchors pex1 and pex6 to peroxisome membranes, possibly to form heteromeric aaa atpase complexes required for the import of proteins into peroxisomes. involved in the import of catalase and proteins containing a pts22 target sequence, but not in import of proteins with a pts1 target sequence.
11817	
11818	may be involved in anchoring calsequestrin to the junctional sarcoplasmic reticulum and allowing its functional coupling with the ryanodine receptor (by similarity).
11819	
11820	
11821	
11822	
11823	seems to function in nuclear protein import as nuclear transport receptor. in vitro, mediates the nuclear import of splicing factor sr proteins sfrs1 and sfrs2, by recognizing phosphorylated rs domains.
11824	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins.
11825	essential for embryogenesis, including development of the placenta, heart and liver (by similarity). plays a role in transcriptional coactivation.
11826	
11827	collagen type iii occurs in most soft connective tissues along with type i collagen.
11828	inhibits the transcriptional activity of spi1 in a dose- dependent manner (by similarity).
11829	
11830	
11831	promotes the exchange of gdp by gtp. together with leukocyte antigen-related (lar) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.
11832	
11833	
11834	v-snare that mediates vesicle transport pathways through interactions with t-snares on the target membrane. these interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. may participate in protein trafficking in the secretory pathway.
11835	
11836	
11837	
11838	required for protein transport from the er to the golgi complex.
11839	may play a role in notch signaling (by similarity).
11840	
11841	
11842	
11843	
11844	responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (lps) by phosphorylating a number of transcription factors, such as elk1 and atf2 and several downstream kinases, such as mapkapk2 and mapkapk5. plays a critical role in the production of some cytokines, for example il-6. may play a role in stabilization of epo mrna during hypoxic stress. isoform mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates elk1 and atf2. isoform exip may play a role in the early onset of apoptosis.
11845	cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an l-selectin- independent fashion. has a monoamine oxidase activity.
11846	
11847	may be involved in transcriptional regulation.
11848	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
11849	transcriptional corepressor that binds to a number of transcription factors. inhibits the transcriptional activation mediated by ctnnb1 and tcf family members in wnt signaling. the effects of full-length tle family members may be modulated by association with dominant-negative aes (by similarity).
11850	
11851	
11852	
11853	may be required for neuronal cell differentiation.
11854	subunit of the 26s proteasome which plays a role in ubiquitin-dependent proteolysis.
11855	
11856	may play a role in the regulation of rhoa gtpase by guanine nucleotide-binding alpha-12 (gna12) and alpha-13 (gna13). acts as guanine nucleotide exchange factor (gef) for rhoa gtpase and may act as gtpase-activating protein (gap) for gna12 and gna13.
11857	
11858	transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (by similarity).
11859	
11860	
11861	plays a major role in tight junction-specific obliteration of the intercellular space (by similarity).
11862	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
11863	
11864	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
11865	thought to transport cystine out of lysosomes.
11866	
11867	
11868	
11869	
11870	
11871	activates erythroid-specific, globin gene expression.
11872	probable histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a central role in histone code. demethylation of lys residue generates formaldehyde and succinate. may be involved in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes (by similarity).
11873	
11874	putative transcription factor.
11875	
11876	
11877	
11878	
11879	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
11880	
11881	cytokine that contributes to the inflammatory response in vivo.
11882	may be involved in brain development during embryogenesis.
11883	
11884	
11885	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
11886	protease which processes procollagen c-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. required for the embryonic development. predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
11887	
11888	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
11889	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
11890	may catalyze alpha-1,3 glycosidic linkages involved in the expression of lewis x/ssea-1 and vim-2 antigens.
11891	
11892	
11893	
11894	
11895	
11896	potent tight-binding inhibitor of several g1 cyclin/cdk complexes (cyclin e-cdk2, cyclin d2-cdk4, and cyclin a-cdk2) and, to lesser extent, of the mitotic cyclin b-cdc2. negative regulator of cell proliferation. may play a role in maintenance of the nonproliferative state throughout life.
11897	binds to the receptor tyrosine kinases ephb4 and epha3. may play a role in constraining the orientation of longitudinally projecting axons (by similarity).
11898	
11899	may be involved in the regulation of gene transcription and chromatin structure.
11900	
11901	
11902	
11903	
11904	
11905	
11906	most effectively accelerate the intrinsic gtpase activity of ypt7. it is also active, but to a lesser extent, on ypt31, ypt32 and ypt1. ypt6 and sec4.
11907	
11908	
11909	3@#$%& exoribonuclease required for 5s rrna maturation and for the proper maturation of the 5@#$%& cistron of the trna-arg3 dicistronic gene. involved with rex2 in the maturation of the 5.8s rrna, and with rex2 and rex3, in the 3@#$%& processing of the u5l snrna.
11910	
11911	may be involved in transcriptional regulation.
11912	
11913	may function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction (by similarity).
11914	
11915	
11916	
11917	
11918	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
11919	this rnase has marked specificity towards the 3@#$%& side of uridine nucleotides.
11920	
11921	
11922	
11923	
11924	
11925	
11926	required for the import and folding of small cysteine- containing proteins (small tim) in the mitochondrial intermembrane space (ims). probably acts by forming a redox cycle with gfer/erv1 that involves a disulfide relay system. precursor proteins to be imported into the ims are translocated in their reduced form into the mitochondria. the oxidized form of mia40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the ims (probable).
11927	
11928	
11929	receptor that may play a role in the perception of bitterness and is gustducin-linked. may play a role in sensing the chemical composition of the gastrointestinal content. the activity of this receptor may stimulate alpha gustducin, mediate plc-beta-2 activation and lead to the gating of trpm5 (by similarity).
11930	
11931	
11932	
11933	
11934	
11935	
11936	
11937	binds specifically and cooperatively to the sph and gt- iic @#$%!enhansons@#$%! (5@#$%&-gtggaatgt-3@#$%&) and activates transcription in vivo in a cell-specific manner. the activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (tif). involved in cardiac development. binds to the m-cat motif.
11938	involved in the transduction of mitogenic signals from the cell membrane to the nucleus. may play a role in the postsynaptic responses of hippocampal neuron.
11939	may be a signaling molecule in the induction and patterning of the embryonic brain.
11940	may be involved in transcriptional regulation.
11941	transfers sialic acid from the donor of substrate cmp- sialic acid to galactose containing acceptor substrates.
11942	may play an important role in fibrillogenesis by controlling lateral growth of collagen ii fibrils.
11943	
11944	
11945	
11946	inter-alpha-trypsin inhibitor, present in plasma and urine, inhibits trypsin, plasmin, and lysosomal granulocytic elastase (by similarity).
11947	
11948	involved in rna polymerase iii-mediated transcription. integral, tightly associated component of the dna-binding tfiiic2 subcomplex that directly binds trna and virus-associated rna promoters.
11949	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
11950	
11951	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
11952	
11953	
11954	required for protein transport from the er to the golgi complex.
11955	may play a role in physiologic lymphocyte functions at mucosal sites.
11956	type ii regulatory chains mediate membrane association by binding to anchoring proteins, including the map2 kinase.
11957	may be an adhesion-like molecule with anti-protease activity.
11958	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
11959	component of the cleavage and polyadenylation specificity factor (cpsf) complex that play a key role in pre-mrna 3@#$%&-end formation, recognizing the aauaaa signal sequence and interacting with poly(a) polymerase and other factors to bring about cleavage and poly(a) addition. cpsf4 binds rna polymers with a preference for poly(u).
11960	probably important in cardiac repolarization. associates with kcne1 (mink) to form the i(ks) cardiac potassium current. elicits a rapidly activating, potassium-selective outward current. muscarinic agonist oxotremorine-m strongly suppresses kcnq1/kcne1 current in cho cells in which cloned kcnq1/kcne1 channels were coexpressed with m1 muscarinic receptors. may associate also with kcne3 (mirp2) to form the potassium channel that is important for cyclic amp-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
11961	fosb interacts with jun proteins enhancing their dna binding activity.
11962	
11963	may be involved in cell migration and/or actin cytoskeleton organization. when expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. required for normal lung cell proliferation and alveolus formation at birth. induces platelet aggregation. does not have any effect on folic acid or amino acid transport. does not function as a water channel or as a regulator of aquaporin-type water channels (by similarity).
11964	transcription factor involved in the induction of oxygen regulated genes. binds to core dna sequence 5@#$%&-[ag]cgtg-3@#$%& within the hypoxia response element (hre) of target gene promoters. regulates the vascular endothelial growth factor (vegf) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. may also play a role in the formation of the endothelium that gives rise to the blood brain barrier. potent activator of the tie-2 tyrosine kinase expression. activation seems to require recruitment of transcriptional coactivators such as crebpb and probably ep300. interaction with redox regulatory protein apex seems to activate ctad.
11965	
11966	
11967	
11968	may be involved in transcriptional regulation.
11969	muscle contraction.
11970	
11971	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
11972	integrin alpha-l/beta-2 is a receptor for icam1, icam2, icam3 and icam4. integrins alpha-m/beta-2 and alpha-x/beta-2 are receptors for the ic3b fragment of the third complement component and for fibrinogen. integrin alpha-x/beta-2 recognizes the sequence g-p-r in fibrinogen alpha-chain. integrin alpha-m/beta-2 recognizes p1 and p2 peptides of fibrinogen gamma chain. integrin alpha-m/beta-2 is also a receptor for factor x. integrin alpha- d/beta-2 is a receptor for icam3 and vcam1.
11973	
11974	
11975	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
11976	
11977	
11978	
11979	
11980	catalyzes the hydrolysis of atp coupled with the exchange of h(+) and k(+) ions across the plasma membrane. responsible for acid production in the stomach.
11981	
11982	
11983	
11984	
11985	may have a role in signal-induced cytoskeletal regulation and/or endocytosis (by similarity).
11986	type i collagen is a member of group i collagen (fibrillar forming collagen).
11987	
11988	stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
11989	
11990	component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level.
11991	
11992	involved in transport of cations (potential).
11993	
11994	plays an essential role in tnfsf11-mediated osteoclastogenesis. involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors (by similarity).
11995	histone h4, along with histone h3, plays a central role in nucleosome formation.
11996	
11997	retains nfe2l2/nrf2 in the cytosol thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.
11998	
11999	this protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate (by similarity).
12000	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
12001	
12002	required for fusion of er-derived vesicles with the golgi during er-to-golgi protein transport, probably by mediating correct membrane localization of ypt1.
12003	
12004	
12005	may be involved in transcriptional regulation.
12006	
12007	type i collagen is a member of group i collagen (fibrillar forming collagen).
12008	
12009	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna.
12010	
12011	necessary for the splicing of pre-mrna. binds to the polypyrimidine tract of introns early during spliceosome assembly. required for the export of mrna out of the nucleus, even if the mrna is encoded by an intron-less gene.
12012	splice factor that is required for the first atp- dependent step in spliceosome assembly and for the interaction of u2 snrnp with the branchpoint. has weak rna-dependent atpase activity. required for mrna export.
12013	
12014	
12015	
12016	strong transcriptional activator; dna-binding protein that specifically recognize the sequence 5@#$%&-yaac[gt]g-3@#$%&. could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and b-lymphoid cells.
12017	
12018	
12019	
12020	
12021	
12022	mrs4 suppresses a mitochondrial splice defect in the first intron of the cob gene. it may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). not essential.
12023	involved in cytokinesis (potential). can bind to gtp and exert gtpase activity.
12024	transcriptional activator that binds to the enhancer of the adenovirus e1a gene; the core-binding sequence is 5@#$%&[ac]gga[at]gt-3@#$%&.
12025	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
12026	not yet known.
12027	
12028	
12029	binds and activates tie2 receptor by inducing its tyrosine phosphorylation. implicated in endothelial developmental processes later and distinct from that of vegf. appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. mediates blood vessel maturation/stability. it may play an important role in the heart early development.
12030	
12031	
12032	calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. phosphorylates camk1, camk1d, camk1g and camk4. involved in regulating cell apoptosis. promotes cell survival by phosphorylating akt1/pkb that inhibits pro-apoptotic bad/bcl2-antagonist of cell death.
12033	
12034	buffers cytosolic calcium. may stimulate a membrane ca(2+)-atpase and a 3@#$%&,5@#$%&-cyclic nucleotide phosphodiesterase.
12035	
12036	
12037	
12038	
12039	
12040	
12041	
12042	
12043	
12044	
12045	involved in the synthesis of the gdp-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (by similarity).
12046	
12047	
12048	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
12049	
12050	
12051	not known.
12052	binds to, and destabilizes, ornithine decarboxylase. does not accelerate ornithine decarboxylase degeneration. oaz3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.
12053	
12054	
12055	
12056	
12057	glycosyltransferase required for the biosynthesis of heparan-sulfate. the ext1/ext2 complex possesses substantially higher glycosyltransferase activity than ext1 or ext2 alone. appears to be a tumor suppressor.
12058	
12059	
12060	
12061	cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a bmp antagonist required for early limb outgrowth and patterning in maintaining the fgf4-shh feedback loop. down-regulates the bmp4 signaling in a dose-dependent manner. acts as inhibitor of monocyte chemotaxis (by similarity).
12062	may play a role in the proliferation or differentiation of keratinocytes.
12063	
12064	implicated in the suppression of cell death. interacts with the bcl-2 and adenovirus e1b 19 kda proteins (by similarity).
12065	may play a role in antiviral host defense. protects against infection by a neurovirulent strain of sindbis virus. may play a role in autophagy.
12066	
12067	
12068	
12069	
12070	
12071	its interaction with phyh suggests a role in the development of the central system.
12072	
12073	
12074	extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development (by similarity).
12075	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
12076	
12077	
12078	
12079	may be involved in transcriptional regulation.
12080	negatively regulates tcr (t-cell antigen receptor)- mediated signaling in t-cells. involved in positive selection of t-cells.
12081	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
12082	
12083	one of the major glycoproteins of thymocytes and t lymphocytes. plays a role in the physicochemical properties of the t-cell surface and in lectin binding. presents carbohydrate ligands to selectins. has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. is a counter receptor for sn/siglec-1 (by similarity). during t-cell activation is actively removed from the t-cell-apc (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (by similarity).
12084	
12085	receptor for atp that acts as a ligand gated ion channel.
12086	affects the rate of fibrils formation. may have a primary role in collagen fibrillogenesis (by similarity).
12087	
12088	
12089	
12090	
12091	component c2 which is part of the classical pathway of the complement system is cleaved by activated factor c1 into two fragments: c2b and c2a. c2a, a serine protease, then combines with complement factor 4b to generate the c3 or c5 convertase.
12092	
12093	
12094	
12095	
12096	
12097	
12098	
12099	
12100	receptor for gastrin and cholecystokinin. the ckk-b receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. this receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system (by similarity).
12101	prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
12102	belongs to the 26s multisubunit protease, which is required for ubiquitin-dependent proteolysis. does not bind ubiquitin polymers.
12103	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
12104	specific inhibition of calpain (calcium-dependent cysteine protease). plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
12105	promotes motor nerve regeneration (by similarity). may be involved in intracellular vesicle traffic.
12106	
12107	
12108	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
12109	
12110	
12111	
12112	collagen type iv is specific for basement membranes.
12113	protein phosphatase 1 (pp1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. involved in regulation of ionic conductances and long-term synaptic plasticity. may play an important role in dephosphorylating substrates such as the postsynaptic density-associated ca(2+)/calmodulin dependent protein kinase ii.
12114	binds vldl and transports it into cells by endocytosis. in order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. binding to reelin induces tyrosine phosphorylation of dab1 and modulation of tau phosphorylation (by similarity).
12115	
12116	may be specifically involved in neuronal and hepatic functions. is a c3 toxin-insensitive member of the rho subfamily (by similarity).
12117	expressed by macrophages in chronic inflammations. also expressed in epithelial cells constitutively or induced during dermatoses. may interact with components of the intermediate filaments in monocytes and epithelial cells.
12118	acts as a negative regulator of the proliferation of normal cells by interacting strongly with cdk4 and cdk6. this inhibits their ability to interact with cyclins d and to phosphorylate the retinoblastoma protein.
12119	
12120	acts as a negative regulator of the proliferation of normal cells by interacting strongly with cdk4 and cdk6. this inhibits their ability to interact with cyclins d and to phosphorylate the retinoblastoma protein.
12121	
12122	
12123	required for protein transport from the er to the golgi complex.
12124	may facilitate double-stranded rna-regulated gene expression at the level of post-transcription. can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (gcase) and other mrnas and functions at the initiation phase of gcase mrna translation, probably by inhibiting its binding to polysomes. can regulate protein arginine n- methyltransferase 1 activity. may regulate transcription of the il2 gene during t-cell activation. can promote the formation of stable dna-dependent protein kinase holoenzyme complexes on dna.
12125	guanine nucleotide exchange factor that potentially links pathways that signal through rac1, rhoa and cdc42. catalyzes guanine nucleotide exchange on rhoa and cdc42 and interacts specifically with the gtp-bound form of rac1, suggesting that it functions as an effector of rac1. may also participate in axonal transport in the brain. becomes activated and highly tumorigenic by truncation of the n-terminus (by similarity).
12126	
12127	may act as a charged protein scaffold to promote snrnp assembly or strengthen snrnp-snrnp interactions through nonspecific electrostatic contacts with rna.
12128	
12129	
12130	
12131	
12132	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
12133	
12134	
12135	
12136	receptor for prostaglandin e2 (pge2). the activity of this receptor is mediated by g(s) proteins that stimulate adenylate cyclase. has a relaxing effect on smooth muscle. may play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
12137	cell surface proteoglycan that bears heparan sulfate. may be involved in the development of kidney tubules and of the central nervous system (by similarity).
12138	
12139	
12140	
12141	
12142	
12143	
12144	
12145	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
12146	
12147	
12148	
12149	
12150	
12151	
12152	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
12153	
12154	
12155	protease which specifically processes pro-lysyl oxidase. required for the embryonic development. predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
12156	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
12157	
12158	
12159	
12160	
12161	belongs to an adhesion system, probably together with the e-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (ajs). nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
12162	
12163	
12164	
12165	mediates rac1-dependent reorganization of actin filaments (by similarity). participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
12166	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
12167	may be involved in transcriptional regulation.
12168	likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. may play a role in the differentiation of spermatozoa and oocytes.
12169	likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. may play a role in the differentiation of spermatozoa and oocytes.
12170	outward rectifying potassium channel.
12171	involved in poly(a)+ rna transport.
12172	
12173	appears to be involved in myelination. could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and k(+)-selective (by similarity).
12174	
12175	
12176	
12177	
12178	
12179	required for maturation of the 25s and 5.8s ribosomal rnas. required for proper processing at four distinct sites located within the internal transcribed spacers its1 and its2 and the 3@#$%& external spacer. may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rrna (by similarity).
12180	may be involved in the assembly, secretion and targeting of tgfb1 to sites at which it is stored and/or activated. may play critical roles in controlling and directing the activity of tgfb1. may have a structural role in the extra cellular matrix (ecm).
12181	ileal protein which stimulates gastric acid and pepsinogen secretion. seems to be able to bind to bile salts and bilirubins.
12182	
12183	
12184	
12185	
12186	
12187	
12188	
12189	
12190	involved in pyrimidine base degradation. catalyzes the reduction of uracil and thymine. also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
12191	
12192	
12193	
12194	gtpase activator for the rho, rac and cdc42 proteins, converting them to the putatively inactive gdp-bound state. cdc42 seems to be the preferred substrate.
12195	required for tcr (t-cell antigen receptor)- and pre-tcr- mediated signaling, both in mature t-cells and during their development. involved in fcgr3 (low affinity immunoglobulin gamma fc region receptor iii)-mediated signaling in natural killer cells and fcer1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, pkc activation, mapk activation or cytoskeletal reorganization through the recruitment of plcg1, grb2, grap2, and other signaling molecules.
12196	required for tcr (t-cell antigen receptor)- and pre-tcr- mediated signaling, both in mature t-cells and during their development. involved in fcgr3 (low affinity immunoglobulin gamma fc region receptor iii)-mediated signaling in natural killer cells and fcer1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, pkc activation, mapk activation or cytoskeletal reorganization through the recruitment of plcg1, grb2, grap2, and other signaling molecules.
12197	
12198	dna primase is the polymerase that synthesizes small rna primers for the okazaki fragments made during discontinuous dna replication.
12199	may contribute to the development of sarcomas.
12200	
12201	
12202	catalyzes the nadph-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and l- xylulose. participates in the uronate cycle of glucose metabolism. may play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
12203	
12204	
12205	
12206	
12207	
12208	may play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (nr) and acts in cooperation with ncoa2 and carm1. involved in estrogen hormone signaling. involved in early embryonic development (by similarity). may play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration.
12209	
12210	may function in combinations with otx1/2 to specify cell fates in the developing central nervous system.
12211	
12212	
12213	plays an important role in the regulation of microtubule (mt) dynamics, regulating the density, length distribution and stability of interphase mts. participates in generating polarized mt networks in migrating fibroblasts.
12214	
12215	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna (by similarity).
12216	
12217	muscle contraction.
12218	transcriptional factor. activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta- globin gene and represses promoters containing sp1-like binding sites inhibiting cell growth.
12219	
12220	
12221	nuclease that induces dna fragmentation and chromatin condensation during apoptosis. degrades naked dna and induces apoptotic morphology.
12222	mediates hepatobiliary excretion of numerous organic anions. may function as a cellular cisplatin transporter.
12223	may antagonize nodal signaling (by similarity).
12224	this is the heme a-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
12225	the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the er, via the golgi up to the trans golgi network. coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-er transport of dilysine-tagged proteins. in mammals, the coatomer can only be recruited by membranes associated to adp-ribosylation factors (arfs), which are small gtp-binding proteins; the complex also influences the golgi structural integrity, as well as the processing, activity, and endocytic recycling of ldl receptors (by similarity).
12226	
12227	
12228	
12229	
12230	
12231	inhibitor of serine proteases. its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.
12232	
12233	seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.
12234	binds highly specifically to rhoa, rhoc and rac proteins, but does not appear to catalyze guanine nucleotide exchange (by similarity).
12235	drastically down-regulated in response to pdgf-bb or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. seems to play a role in the development of the embryonic vascular system.
12236	
12237	
12238	
12239	phosphorylates inhibitors of nf-kappa-b thus leading to the dissociation of the inhibitor/nf-kappa-b complex and ultimately the degradation of the inhibitor. may play a special role in the immune response (by similarity).
12240	
12241	involved in exocytosis by regulating a late step in synaptic vesicle fusion. could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (by similarity).
12242	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
12243	
12244	
12245	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules.
12246	
12247	
12248	
12249	probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. may also participate in functions of the mature nervous system.
12250	
12251	
12252	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
12253	can be a regulatory factor required for the differentiation and/or phenotypic maintenance of neurons.
12254	receptor for adenosine. the activity of this receptor is mediated by g proteins which inhibits adenylyl cyclase. possible role in reproduction.
12255	
12256	transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
12257	
12258	
12259	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
12260	
12261	involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. functions as a guanine nucleotide exchange factor (gef), which activates rac rho small gtpases by exchanging bound gdp for free gtp. its gef activity may be enhanced by elmo1.
12262	
12263	
12264	
12265	
12266	
12267	granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. csf- 1 induces cells of the monocyte/macrophage lineage. it plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.
12268	
12269	
12270	glycophorin a is the major intrinsic membrane protein of the erythrocyte. the n-terminal glycosylated segment, which lies outside the erythrocyte membrane, has mn blood group receptors and also binds influenza virus.
12271	growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. binds and activates vegfr-2 (flk1) and vegfr-3 (flt4) receptors.
12272	this tyrosine kinase receptor for fibrillar collagen mediates fibroblast migration and proliferation. contributes to cutaneous wound healing (by similarity).
12273	
12274	inhibitor of the slam self-association. acts by blocking recruitment of the sh2-domain-containing signal-transduction molecule shp-2 to a docking site in the slam cytoplasmic region.
12275	the function of the small subunit is not yet clear.
12276	may be involved in sodium-dependent transport of neutral amino acids or oligopeptides.
12277	
12278	
12279	
12280	critical growth regulator in the pathogenesis of meningiomas.
12281	important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
12282	
12283	involved in the transport of proteins between the endosomes and the trans golgi network.
12284	binds intracellular amyloid-beta. by interacting with amyloid-beta, it may contribute to the neuronal dysfunction associated with alzheimer disease (ad).
12285	
12286	
12287	
12288	possible chloride ion channel.
12289	
12290	
12291	regulates the gdp/gtp exchange reaction of most rab proteins by inhibiting the dissociation of gdp from them, and the subsequent binding of gtp to them.
12292	
12293	may be a signaling adapter molecule involved in p75ntr- mediated apoptosis induced by ngf. plays a role in zinc-triggered neuronal death (by similarity). may play an important role in the pathogenesis of neurogenetic diseases.
12294	guanine nucleotide exchange factor (gef) that modulates the rho family of gtpases. promotes the conversion of some member of the rho family gtpase from the gdp-bound to the gtp-bound form. isoform 1 exhibits no activity toward rhoa, rac1 or cdc42. isoform 2 exhibits decreased gef activity toward cdc42. isoform 3 exhibits a weak but significant activity toward rac1 and cdc42. isoform 4 exhibits significant activity toward rhoa and cdc42. the truncated dbl oncogene is active toward rhoa, rac1 and cdc42.
12295	not known; binds heterotrimeric g proteins.
12296	
12297	
12298	
12299	
12300	
12301	plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity.
12302	component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnrnp). hnrnp play an important role in processing of precursor mrna in the nucleus.
12303	splicing factor that in its dephosphorylated form acts as a general repressor of pre-mrna splicing. seems to interfere with the u1 snrnp 5@#$%&-splice recognition of snrp70. required for splicing repression in m-phase cells and after heat shock. may be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
12304	
12305	
12306	structural component of hyaline cartilage and vitreous of the eye.
12307	component of the origin recognition complex (orc) that binds origins of replication. it has a role in both chromosomal replication and mating type transcriptional silencing. binds to the ars consensus sequence (acs) of origins of replication in an atp-dependent manner.
12308	responsible for the deiodination of t4 (3,5,3@#$%&,5@#$%&- tetraiodothyronine) into t3 (3,5,3@#$%&-triiodothyronine) and of t3 into t2 (3,3@#$%&-diiodothyronine). plays a role in providing a source of plasma t3 by deiodination of t4 in peripheral tissues such as liver and kidney.
12309	
12310	catalytic component of isw1-type complexes, which act by remodelling the chromatin by catalyzing an atp-dependent alteration in the structure of nucleosomal dna. they are involved in coordinating transcriptional repression, activation and elongation phases. the isw1a complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome. the isw1b complex acts within coding regions to control the amount of rna polymerase ii released into productive elongation and to coordinate elongation with termination and pre- mrna processing.
12311	resistance to tetracycline by an active tetracycline efflux. this is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. this protein functions as a metal-tetracycline/h(+) antiporter.
12312	neural extracellular matrix (ecm) protein involved in interactions with different cells and matrix components. these interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. binding to cell surface gangliosides inhibits rgd-dependent integrin-mediated cell adhesion and results in an inhibition of ptk2 (fak) phosphorylation and cell detachment. binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. interaction with cntn1 induces a repulsion of neurons and an inhibition of neurite outgrowth. interacts with scn2b may play a crucial role in clustering and regulation of activity of sodium channels at nodes of ranvier. tnr-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with fn1 and mediate inhibition of cell adhesion and neurite outgrowth. the highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of tnr over the course of development and during synapse maintenance (by similarity).
12313	
12314	component of the cytoplasmic fibrils of the nuclear pore complex implicated in nuclear protein import. its n-terminus is involved in activation of oncogenic kinases.
12315	
12316	binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
12317	
12318	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. srp9 together with srp14 and the alu portion of the srp rna, constitutes the elongation arrest domain of srp. the complex of srp9 and srp14 is required for srp rna binding.
12319	
12320	necessary for scanning and involved in initiation site selection. promotes the assembly of 48s ribosomal complexes at the authentic initiation codon of a conventional capped mrna.
12321	
12322	
12323	
12324	this protein is a component of ribonucleosomes. could be needed to organize a concentration gradient of a dorsalizing morphogen (dm) originating in the germinal vesicle. at least one of the isoforms is essential in somatic tissues.
12325	
12326	
12327	may be involved in transcriptional regulation.
12328	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to g(i)-alpha and g(o)-alpha, but not to g(s)-alpha (by similarity).
12329	major role in the synthesis of nucleoside triphosphates other than atp. the atp gamma phosphate is transferred to the ndp beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
12330	
12331	
12332	catalyzes the oxidation of l-alpha-hydroxy acids as well as, more slowly, that of l-alpha-amino acids.
12333	acyl-coa synthetase involved in bile acid metabolism. proposed to catalyze the first step in the conjugation of c24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their coa thioesters. seems to activate secondary bile acids entering the liver from the enterohepatic circulation. in vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (thca), the c27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
12334	binds unprenylated rab proteins, presents it to the catalytic rab ggtase dimer, and remains bound to it after the geranylgeranyl transfer reaction. the component a is thought to be regenerated by transferring its prenylated rab back to the donor membrane. less effective than rep-1 in supporting prenylation of rab3 family.
12335	
12336	thiol protease. key protease responsible for the removal of the invariant chain from mhc class ii molecules. the bond- specificity of this proteinase is in part similar to the specificities of cathepsin l and cathepsin n.
12337	
12338	
12339	
12340	
12341	acts upon elastin.
12342	
12343	may be involved in transcriptional regulation.
12344	promotes the exchange of ran-bound gdp by gtp. involved in the regulation of onset of chromosome condensation in the s phase. binds to the chromatin. rcc1/ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated dna.
12345	binds to the metal-regulating-element (mre) of metallothionein-1a gene promoter. binding is zinc-dependent (by similarity).
12346	
12347	may be involved in transcriptional regulation.
12348	
12349	could participate in polarized transport, in the assembly and/or the activity of tight junctions.
12350	
12351	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
12352	
12353	sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. controls the reabsorption of sodium in kidney, colon, lung and sweat glands. also plays a role in taste perception.
12354	promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including vega-a, vega-c, mmp1, mmp3, timp1, upa, pai-1 and integrins alpha-3 and alpha-5. cyr61-mediated gene regulation is dependent on heparin-binding. down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
12355	promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including vega-a, vega-c, mmp1, mmp3, timp1, upa, pai-1 and integrins alpha-3 and alpha-5. cyr61-mediated gene regulation is dependent on heparin-binding. down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
12356	required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier. functions as a homophilic cell-adhesion molecule. may play a role in early neuronal differentiation and axon outgrowth.
12357	
12358	
12359	
12360	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
12361	
12362	
12363	
12364	
12365	
12366	
12367	
12368	
12369	lysophoshatidylglycerol (lpg) specific acyltransferase that recognizes various acyl-coas and lpgs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-coas and oleoyl-coa as acyl donors. prefers oleoyl-lpg over palmitoyl-lpg as an acyl receptor and oleoyl-coa over lauroyl-coa as an acyl donor.
12370	putative receptor involved in the development of neural and epithelial tissues.
12371	could be a transcriptional activating factor. functions as a form of i-kappa-b specific for nf-kappa-b p50 subunit inhibiting its translocation to the nucleus.
12372	
12373	
12374	
12375	component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. nua4 may also play a direct role in dna repair when directly recruited to sites of dna damage.
12376	
12377	could be involved in bone formation.
12378	
12379	integrin alpha-8/beta-1 is a receptor for fibronectin and cytotactin. it recognizes the sequence r-g-d in its ligands.
12380	potent transcriptional repressor that binds to the h1 element of the ets2 promoter. may regulate other genes involved in cellular proliferation.
12381	
12382	
12383	
12384	substrate-recognition component of the scf (skp1-cul1-f- box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. regulates the stability of ctnnb1 and participates in wnt signaling.
12385	
12386	
12387	may bind nucleic acids or oligosaccharides.
12388	has broad nucleoside selectivity (uridine, ademosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes.
12389	
12390	
12391	
12392	required for kinetochore localization of bub1.
12393	
12394	sequence-specific dna-binding transcription factor. binds to two specific dna sites located in the promoter region of hoxa4.
12395	
12396	
12397	
12398	pre-mrna processing factor involved in disassembly of spliceosomes after the release of mature mrna.
12399	
12400	recognizes the dna sequence 5@#$%&-attaa-3@#$%&. may play a role in hematopoietic differentiation.
12401	
12402	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release. has anti-apoptotic activity.
12403	in the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (krtap), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. the matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
12404	
12405	putative odorant receptor.
12406	orphan receptor. interaction with rxr shifts rxr from its role as a silent dna-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by lxres. lxres are dr4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. plays an important role in the regulation of cholesterol homeostasis.
12407	protein transport. probably involved in vesicular traffic (by similarity).
12408	
12409	
12410	may affect the rate of fibrils formation (by similarity). may be implicated in the dilatation of the rat cervix.
12411	
12412	
12413	plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. may potently compresse chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly contains 2 nonspecific dsdna-binding sites which may promote dna cross-bridging. exploited by retroviruses for inhibiting self- destructing autointegration of retroviral dna, thereby promoting integration of viral dna into the host chromosome.
12414	
12415	required for fusion of er-derived vesicles with the golgi during er-to-golgi protein transport. may be involved in proper membrane localization of rab gtpases.
12416	
12417	degrades extracellular matrix. proposed to play a role in breast cancer invasion and metastasis. exhibits trypsin-like activity as defined by cleavage of synthetic substrates with arg or lys as the p1 site.
12418	mediator of programmed cell death (apoptosis).
12419	transcriptional coactivator that specifically associates with either oct1 or oct2. it boosts the oct-1 mediated promoter activity and to a lesser extent, that of oct-2. it has no intrinsic dna-binding activity. it recognizes the pou domains of oct1 and oct2. it is essential for the response of b-cells to antigens and required for the formation of germinal centers.
12420	may be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium atpase.
12421	
12422	
12423	
12424	in vitro, acts as a receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5).
12425	
12426	
12427	
12428	
12429	
12430	clp cleaves peptides in various proteins in a process that requires atp hydrolysis. clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.
12431	functions as a component of the pcaf complex. the pcaf complex is capable of efficiently acetylating histones in a nucleosomal context. the pcaf complex could be considered as the human version of the yeast saga complex.
12432	
12433	
12434	
12435	suppresses tnf- and cd40-induced nfkb1 activity at the level of the ikk complex, by inhibiting nfkbia degradation induced by tnf. when associated with pycard, activates casp1, leading to the secretion of mature proinflammatory cytokine il1b. may be a component of the inflammasome, a protein complex which also includes pycard, card8 and casp1 and whose function would be the activation of proinflammatory caspases.
12436	creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
12437	
12438	also exhibits a dipeptidyl-peptidase iv type activity. in vitro, cleaves gly-pro-amc.
12439	this receptor binds insulin and has a tyrosine-protein kinase activity. isoform short has a higher affinity for insulin. mediates the metabolic functions of insulin. binding to insulin stimulates association of the receptor with downstream mediators including irs1 and phosphatidylinositol 3@#$%&-kinase (pi3k). can activate pi3k either directly by binding to the p85 regulatory subunit, or indirectly via irs1.
12440	
12441	the epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.
12442	ribonucleoprotein particle composed of a single polypeptide and one of four small rna molecules. it is present in all mammalian cells studied but has no known function. at least two isoforms are present in nucleated and red blood cells, and tissue specific differences in ro/ssa proteins have been identified. the common feature of these proteins is their ability to bind hy rnas.
12443	binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
12444	
12445	receptor for class i mhc antigens. recognizes a broad spectrum of hla-a, hla-b, hla-c and hla-g alleles. involved in the down-regulation of the immune response and the development of tolerance. competes with cd8a for binding to class i mhc antigens. inhibits fcgr1a-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
12446	
12447	collagen type iii occurs in most soft connective tissues along with type i collagen.
12448	
12449	
12450	promotes apoptosis by activating caspases in the cytochrome c/apaf-1/caspase-9 pathway. acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (iap).
12451	
12452	
12453	thought to stabilize the calcium channel in an inactivated (closed) state (by similarity).
12454	atp-binding rna helicase involved in the biogenesis of 60s ribosomal subunits. required for the normal formation of 18s rrna through the processing of pre-rrnas at sites a0, a1 and a2, and the normal formation of 25s and 5.8s rrnas through the processing of pre-rrnas at sites c1 and c2.
12455	
12456	
12457	
12458	carries out a dual function: signal transduction and activation of transcription. involved in interleukin-4 signalling.
12459	
12460	sequesters mitogen-activated protein kinases (mapks) such as mapk1, mapk3 and mapk14 in the cytoplasm in an inactive form. the mapks bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase a complex releases the mapks for activation and translocation into the nucleus (by similarity).
12461	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to a promoter element of the lactase-phlorizin hydrolase gene.
12462	
12463	may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. oas3 synthesizes preferentially dimeric 2@#$%&,5@#$%&-oligoadenylate molecules. gtp can be an alternative substrate.
12464	may be involved in transcriptional regulation.
12465	
12466	
12467	
12468	
12469	paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.
12470	
12471	receptor for prostaglandin e2 (pge2). the activity of this receptor is mediated by g(q) proteins which activate a phosphatidylinositol-calcium second messenger system. may play a role as an important modulator of renal function. implicated the smooth muscle contractile response to pge2 in various tissues.
12472	
12473	receptor for tnfsf7/cd27l. may play a role in survival of activated t-cells. may play a role in apoptosis through association with siva.
12474	
12475	required for protein transport from the er to the golgi complex.
12476	actin-binding protein involved in motile and morphological processes. inhibits actin polymerization, likely by sequestering g-actin. by capping the barbed ends of filaments, it also regulates motility. seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (by similarity).
12477	
12478	
12479	transcription factor involved in regulating gene activity following the primary growth factor response. binds to the dna sequence 5@#$%&-tga[cg]tca-3@#$%&.
12480	
12481	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
12482	
12483	binds to the c-terminal pts1-type tripeptide peroxisomal targeting signal (skl-type) and plays an essential role in peroxisomal protein import.
12484	
12485	
12486	binds the poly(a) tail of mrna. may be involved in cytoplasmic regulatory processes of mrna metabolism. binds poly(a) with a slightly lower affinity as compared to pabpc1.
12487	orphan receptor.
12488	
12489	
12490	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
12491	
12492	
12493	
12494	
12495	may be involved in the control of the cell cycle at the g1/s (start) and g2/m (mitosis) transitions. may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
12496	component of the exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature nuclear complex. also associated with the gtpase ran. has a 3@#$%&-5@#$%& exonuclease activity.
12497	
12498	
12499	involved in the homologous recombination repair (hrr) pathway of double-stranded dna, thought to repair chromosomal fragmentation, translocations and deletions.
12500	involved in the homologous recombination repair (hrr) pathway of double-stranded dna breaks arising during dna replication or induced by dna-damaging agents. may promote the assembly of presynaptic rad51 nucleoprotein filaments. the rad51b- rad51c dimer exhibits single-stranded dna-dependent atpase activity. the bcdx2 complex binds single-stranded dna, single- stranded gaps in duplex dna and specifically to nicks in duplex dna.
12501	
12502	may be involved in transcriptional regulation.
12503	
12504	gtpase-activating protein for rho family members. may play a role in the reduction of the p21rasgtpase-activating potential of p120gap.
12505	type i collagen is a member of group i collagen (fibrillar forming collagen).
12506	
12507	docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. may serve as an activator of src and a downstream effector. interacts with the sh3 domain of fyn and with crk, src, and yes (by similarity).
12508	may inhibit cell replication either by catalyzing the oxidation of estrogen and androgen or by converting cortisone in cortisol.
12509	
12510	probable transcription factor.
12511	
12512	
12513	probably plays a role in the development of the brain and the sense organs. can bind to the bcd target sequence (bts): 5@#$%&-tctaatccc-3@#$%&.
12514	may play a role in cell cycle regulation. dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. interacts with cyclin- dependent kinases such as cdc2, cdk2 and cdk3. does not interact with cdk4.
12515	phosphorylase is an important allosteric enzyme in carbohydrate metabolism. enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. however, all known phosphorylases share catalytic and structural properties.
12516	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
12517	may be involved in sperm maturation and/or fertilization.
12518	
12519	
12520	may be involved in the regulation of the lipid composition of sperm membranes during the maturation in the epididymis (by similarity).
12521	
12522	responsible for the deiodination of t4 (3,5,3@#$%&,5@#$%&- tetraiodothyronine) into t3 (3,5,3@#$%&-triiodothyronine). essential for providing the brain with appropriate levels of t3 during the critical period of development.
12523	may play a role in germ line formation.
12524	
12525	
12526	acts on galnac. also acts as a galactokinase when galactose is present at high concentrations.
12527	sodium-dependent and purine-selective transporter. exhibits the transport characteristics of the nucleoside transport system cif or n1 subtype (n1/cif) (selective for purine nucleosides and uridine). plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.
12528	
12529	plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. localizes to the interzone of mitotic spindles.
12530	subunit of clathrin-associated adaptor protein complex 2 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. ap-2 complex seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface.
12531	the s.cerevisiae ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-amp.
12532	cleaves the membrane-bound precursor of tnf-alpha at 76- ala-|-val-77 to its mature soluble form. responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-a2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (app). contributes to the normal cleavage of the cellular prion protein. involved in the cleavage of the adhesion molecule l1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. controls also the proteolytic processing of notch and mediates lateral inhibition during neurogenesis (by similarity).
12533	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
12534	thought to regulate cation conductance. may regulate accn1 and accn3 gating (by similarity).
12535	
12536	medin is the main constituent of aortic medial amyloid.
12537	may play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (by similarity).
12538	
12539	may play a regulatory role in synaptic vesicle recycling.
12540	target-derived survival factor for peripheral sensory sympathetic neurons.
12541	involved in regulation of the actin cytoskeleton. may regulate the was actin-bundling activity. bridges the interaction between abl1 and ptpn18 leading to the abl1 dephosphorylation. may play a role as a scaffold protein between ptpn12 and was and allows ptpn12 to dephosphorylate was. has the potential to physically couple cd2 and cd2ap to was. acts downstream of cd2 and cd2ap to recruit was to the t-cell:apc contact site so as to promote the actin polymerization required for synapse induction during t-cell activation (by similarity). down-regulates cd2- stimulated adhesion through the coupling of ptpn12 to cd2.
12542	
12543	
12544	
12545	may be involved in several stages of intracellular trafficking. plays a role in targeting ligand-activated egfr to the lysosomes for degradation after endocytosis from the cell surface and release from the golgi.
12546	
12547	
12548	inhibitor of hgf activator. also acts as an inhibitor of matriptase (st14).
12549	
12550	
12551	stimulates the release of tumor necrosis factor alpha and il-1beta from the monocytic cell line thp-1.
12552	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l.
12553	
12554	may act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (zgm) and aggregated secretory proteins during granule formation in the tgn (by similarity).
12555	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
12556	probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. is not an essential protein. involved in substrate recognition in ubiquitin-dependent degradation.
12557	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l.
12558	
12559	
12560	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
12561	
12562	tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. it seems to be required for cartilage and growth plate development.
12563	
12564	
12565	
12566	type i collagen is a member of group i collagen (fibrillar forming collagen).
12567	involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.
12568	
12569	
12570	
12571	
12572	cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases (by similarity).
12573	3@#$%& exoribonuclease required for 5s rrna maturation and for the proper maturation of the 5@#$%& cistron of the trna-arg3 dicistronic gene. involved with rex2 in the maturation of the 5.8s rrna, and with rex2 and rex3, in the 3@#$%& processing of the u5l snrna.
12574	
12575	cleaves ubiquitin fusion protein substrates. binds to the herpes virus protein vmw110 which may therefore modulate its substrate specificity or activity to stabilize viral proteins.
12576	
12577	plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. interacts with other spliceosomal components, via the rs domains, to form a bridge between the 5@#$%& and 3@#$%& splice site binding components, u1 snrnp and u2af. can stimulate binding of u1 snrnp to a 5@#$%&-splice-site-containing pre-mrna. binds to purine-rich rna sequences, either the octamer, 5@#$%&-rgaagaac-3@#$%& (r=a or g) or the decamers, aggacagagc/aggacgaagc. three copies of the octamer constitute a powerful splicing enhancer in vitro, the asf/sf2 splicing enhancer (ase) which can specifically activate ase- dependent splicing. isoform asf-2 and isoform asf-3 act as splicing repressors.
12578	plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. interacts with other spliceosomal components, via the rs domains, to form a bridge between the 5@#$%& and 3@#$%& splice site binding components, u1 snrnp and u2af. can stimulate binding of u1 snrnp to a 5@#$%&-splice-site-containing pre-mrna. binds to purine-rich rna sequences, either the octamer, 5@#$%&-rgaagaac-3@#$%& (r=a or g) or the decamers, aggacagagc/aggacgaagc. three copies of the octamer constitute a powerful splicing enhancer in vitro, the asf/sf2 splicing enhancer (ase) which can specifically activate ase- dependent splicing. isoform asf-2 and isoform asf-3 act as splicing repressors.
12579	
12580	it has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1. it is essential for growth or germination at 37 degrees celsius. may have a role in the heat shock response. involved in trna splicing and cell separation.
12581	
12582	nmda receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine.
12583	orphan receptor.
12584	appears to mediate neuronal differentiation.
12585	may mediate accelerated atp-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
12586	
12587	
12588	suppresses tnf- and cd40-induced nfkb1 activity at the level of the ikk complex, by inhibiting nfkbia degradation induced by tnf. when associated with pycard, activates casp1, leading to the secretion of mature proinflammatory cytokine il1b. may be a component of the inflammasome, a protein complex which also includes pycard, card8 and casp1 and whose function would be the activation of proinflammatory caspases.
12589	
12590	couples signals from receptor and cytoplasmic tyrosine kinases to the ras signaling pathway.
12591	couples signals from receptor and cytoplasmic tyrosine kinases to the ras signaling pathway.
12592	seems to play a negative regulatory role in prpp synthesis.
12593	muscle contraction.
12594	specific gef for rhoa activation and the regulation of vascular smooth muscle contractility.
12595	
12596	granulin-4 promotes proliferation of the epithelial cell line a431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
12597	
12598	
12599	collagen type ii is specific for cartilaginous tissues. it is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
12600	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
12601	
12602	may play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle.
12603	
12604	
12605	major constituent of messenger ribonucleoprotein particles (mrnps). involved in the regulation of the stability and/or translation of germ cell mrnas. binds to y-box consensus promoter element. binds to full length mrna with high affinity in a sequence-independent manner. binds to short rna sequences containing the consensus site 5@#$%&-uccauca-3@#$%& with low affinity and limited sequence specificity. its binding with maternal mrnas is necessary for its cytoplasmic retention. may mark specific mrnas (those transcribed from y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mrna storage/translational delay (by similarity).
12606	
12607	beta-1,3-galactosyltransferase that transfers galactose from udp-galactose to substrates with a terminal beta-n- acetylglucosamine (beta-glcnac) residue. can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. inactive towards substrates with terminal alpha-n-acetylglucosamine (alpha-glcnac) or alpha-n-acetylgalactosamine (alpha-galnac) residues.
12608	
12609	
12610	involved in the initiation of dna replication. also participates in checkpoint controls that ensure dna replication is completed before mitosis is initiated.
12611	
12612	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
12613	
12614	may function in the assembly or regulation of proteins in the cornified envelope. the lim domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.
12615	suggested to be involved in kindling epileptogenesis and hippocampal plasticity. has a strong proteolytic activity against fibronectin (by similarity).
12616	
12617	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
12618	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to both g(i)-alpha and g(q)- alpha (by similarity).
12619	potential tumor suppressor for renal cell carcinoma.
12620	may play a role in the response to environmental stress. appears to act upstream of the jun n-terminal pathway. may play a role in hematopoietic lineage decisions and growth regulation.
12621	required for normal golgi function (by similarity).
12622	
12623	
12624	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
12625	
12626	
12627	
12628	
12629	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii is composed of at least five proteins: the sec23/24 complex, the sec13/31 complex, and the protein sar1. acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex (by similarity).
12630	forms a voltage-independent potassium channel activated by intracellular calcium. activation is followed by membrane hyperpolarization. thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. the channel is blocked by apamin.
12631	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
12632	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins that stimulate adenylate cyclase.
12633	
12634	
12635	
12636	
12637	activates nf-kappa-b via bcl10.
12638	
12639	receptor for acidic and basic fibroblast growth factors. preferentially binds fgf1.
12640	
12641	
12642	putative odorant receptor.
12643	receptor for tnfsf8/cd30l. may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. regulates gene expression through activation of nf- kappa-b.
12644	
12645	
12646	
12647	
12648	involved in the activation cascade of caspases responsible for apoptosis execution. cleaves poly(adp-ribose) polymerase in vitro, as well as lamins. overexpression promotes programmed cell death (by similarity).
12649	
12650	
12651	
12652	
12653	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
12654	
12655	may be involved in transcriptional regulation.
12656	
12657	
12658	
12659	probable transcription factor. may have a role in myogenesis.
12660	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
12661	
12662	collagen type iv is specific for basement membranes. vital for embryonic development.
12663	muscle contraction.
12664	may be involved in transcriptional regulation.
12665	interacts with dna-repair protein xrcc1 and can correct defective dna strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
12666	
12667	inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. kcnj16 may be involved in the regulation of fluid and ph balance.
12668	receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-msh. this receptor is mediated by g proteins that stimulate adenylate cyclase.
12669	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
12670	
12671	
12672	catalyzes the biosynthesis of phosphatidylinositol (ptdins) as well as ptdins:inositol exchange reaction. may thus act to reduce an excessive cellular ptdins content. the exchange activity is due to the reverse reaction of ptdins synthase and is dependent on cmp, which is tightly bound to the enzyme.
12673	
12674	type i collagen is a member of group i collagen (fibrillar forming collagen).
12675	
12676	
12677	putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. preferentially binds to alpha2,6-linked sialic acid. the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. in the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their sh2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. induces apoptosis in acute myeloid leukemia (in vitro).
12678	
12679	binds to pre-mrna. has high affinity for scaffold- attached region (sar) dna. bind to double- and single-stranded dna and rna.
12680	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to sites in the 5@#$%&-flanking sequence of its coding region with various affinities. the consensus sequences of the high and low affinity binding sites are 5@#$%&-taatga[cg]-3@#$%& and 5@#$%&-ctaatttt- 3@#$%&.
12681	membrane-bound, calcium-inhibitable adenylyl cyclase (by similarity).
12682	involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. may be involved in the release of components of the bilayered coat from the endosomal membrane. the association with escrt-iii complex mediates the atp- dependent disassembly of the escrt-iii complex. in case of infection, the hiv-1 virus takes advantage of it for budding and exocytic cargos of viral proteins.
12683	stimulates the transcription of various genes by recognizing and binding to a ccaat motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
12684	udpgt is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. the major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (dht) > androstane-3alpha,17beta-diol (3alpha-diol) > testosterone > androsterone (adt).
12685	
12686	may act as a zinc-influx transporter.
12687	
12688	
12689	
12690	somewhat implicated in the biogenesis of peroxisomes.
12691	putative adhesion molecule that mediates sialic-acid dependent binding to cells. preferentially binds to alpha2,3 and alpha2,6-linked sialic acid. also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl galnac lactotetraoslylceramide). the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. in the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their sh2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. mediates inhibition of natural killer cells cytotoxicity. may play a role in hemopoiesis. inhibits differentiation of cd34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
12692	granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. this csf induces granulocytes.
12693	
12694	
12695	
12696	
12697	common junctional plaque protein. the membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. the presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.
12698	
12699	
12700	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
12701	catalyzes the nad-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eif-5a precursor protein to form the intermediate deoxyhypusine residue.
12702	this protein is a subunit of the dihydropyridine (dhp) sensitive calcium channel. plays a role in excitation-contraction coupling. the skeletal muscle dhp-sensitive ca(2+) channel may function only as a multiple subunit complex.
12703	
12704	polycomb group (pcg) protein. pcg proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. participates to the etv6-mediated repression. probably plays a role in cell proliferation. overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
12705	
12706	
12707	dorsalizing factor. key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing tgf-beta family bone morphogenetic proteins (bmps) and sequestering them in latent complexes (by similarity).
12708	
12709	
12710	the jnk-interacting protein (jip) group of scaffold proteins selectively mediates jnk signaling by aggregating specific components of the mapk cascade to form a functional jnk signaling module. jip2 inhibits il1 beta-induced apoptosis in insulin-secreting cells. may function as a regulator of vesicle transport, through interations with the jnk-signaling components and motor proteins (by similarity).
12711	
12712	implicated in the control of cell growth.
12713	probable ligand for integrin in the brain. this is a non catalytic metalloprotease-like protein.
12714	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
12715	
12716	
12717	desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
12718	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
12719	kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. phosphorylates preferentially transcription factor atf2.
12720	receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. plays an essential role in leukocyte migration (by similarity).
12721	receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. plays an essential role in leukocyte migration (by similarity).
12722	
12723	plays a role in weight homeostasis. may play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding.
12724	
12725	may be involved in cell-surface proteolysis, cell adhesion or intracellular protein maturation.
12726	
12727	
12728	
12729	
12730	may act as a protease inhibitor to modulate the host immune response against tumor cells.
12731	
12732	produces nitric oxide (no) which is a messenger molecule with diverse functions throughout the body. in macrophages, no mediates tumoricidal and bactericidal actions.
12733	
12734	cysteine protease cleaving the c-terminal amino acid of atg8 to reveal a c-terminal glycine. atg8 ubiquitin-like activity requires the exposure of the glycine at the c-terminus for its conjugation to phosphatidylethanolamine and its insertion to membranes, which is necessary for autophagy. inhibited by n- ethylmaleimide.
12735	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
12736	essential component of the nuclear pore complex. the n- terminal is probably involved in nucleocytoplasmic transport. the c-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex.
12737	
12738	receptor on natural killer (nk) cells for hla-c alleles. does not inhibit the activity of nk cells.
12739	part of the complex catalyzing the transfer of n- acetylglucosamine from udp-n-acetylglucosamine to phosphatidylinositol, the first step of gpi biosynthesis.
12740	
12741	
12742	
12743	interconversion of serine and glycine.
12744	
12745	
12746	probable transcription factor associated with development of alveolar rhabdomyosarcoma.
12747	seems to be involved in the cross-linking of microtubules and microfilaments.
12748	
12749	
12750	induces sprouting in endothelial cells through an autocrine and paracrine action.
12751	
12752	required for membrane traffic to the vacuole.
12753	
12754	
12755	receptor for lysophosphatidic acid (lpa), a mediator of diverse cellular activities. seems to be coupled to the g(i)/g(o), g(12)/g(13), and g(q) families of heteromeric g proteins.
12756	may function as a complex with the chimeric protein runx1/aml1-cbfa2t1/mtg8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). may thus be involved in the repression of aml1-dependent transcription and the induction of g-csf/csf3-dependent cell growth. may be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.
12757	induces disassembly of actin filaments in conjunction with adf/cofilin family proteins (by similarity).
12758	induces disassembly of actin filaments in conjunction with adf/cofilin family proteins (by similarity).
12759	
12760	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. n-cadherin may be involved in neuronal recognition mechanism.
12761	also acts as a tumor suppressor.
12762	
12763	contactins mediate cell surface interactions during nervous system development. has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. probably involved in neuronal activity in the auditory system (by similarity).
12764	
12765	
12766	gtpase-activating protein for rac1 and cdc42. promotes the exchange of rac or cdc42-bound gdp by gtp, thereby activating them. displays serine/threonine kinase activity.
12767	involved in cytokinesis (potential).
12768	gtpase-activating protein for rac and cdc42. promotes the exchange of rac or cdc42-bound gdp by gtp, thereby activating them.
12769	
12770	may have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor.
12771	
12772	
12773	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
12774	may act as a link between cdc42 signaling and regulation of the actin cytoskeleton.
12775	guanine nucleotide exchange factor that interacts with rhoa, but not with rac or cdc42. activates rhoa to promote cytoskeletal contraction and inhibit neurite outgrowth.
12776	
12777	
12778	collagen type iv is specific for basement membranes.
12779	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
12780	
12781	possesses two enzymatic activities: dna synthesis (polymerase) and an exonucleolytic activity that degrades single stranded dna in the 3@#$%& to 5@#$%& direction. required with its accessory proteins (proliferating cell nuclear antigen (pcna) and replication factor c (rfc) or activator 1) for leading strand synthesis. also involved in completing okazaki fragments initiated by the dna polymerase alpha/primase complex.
12782	possesses two enzymatic activities: dna synthesis (polymerase) and an exonucleolytic activity that degrades single stranded dna in the 3@#$%& to 5@#$%& direction. required with its accessory proteins (proliferating cell nuclear antigen (pcna) and replication factor c (rfc) or activator 1) for leading strand synthesis. also involved in completing okazaki fragments initiated by the dna polymerase alpha/primase complex.
12783	
12784	
12785	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
12786	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
12787	
12788	may antagonize nodal signaling and subsequent organization of axial structures during mesodermal patterning (by similarity).
12789	
12790	critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity. phosphorylates phospholamban.
12791	receptor on natural killer (nk) cells for hla-c alleles. does not inhibit the activity of nk cells.
12792	
12793	exhibits outward rectification in a physiological k(+) gradient and mild inward rectification in symmetrical k(+) conditions.
12794	
12795	
12796	required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier. functions as a homophilic cell-adhesion molecule. may play a role in early neuronal differentiation and axon outgrowth.
12797	
12798	
12799	could play a significant role in the signal transduction of hematopoietic cells. may regulate tyrosine kinase activity of src-family members in brain by specifically phosphorylating their c-terminal regulatory tyrosine residue which acts as a negative regulatory site. it may play an inhibitory role in the control of t-cell proliferation.
12800	
12801	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
12802	
12803	
12804	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
12805	
12806	
12807	
12808	putative odorant receptor.
12809	
12810	
12811	
12812	transcriptional repressor.
12813	transcriptional repressor.
12814	does not bind dna by itself. recruits histone deacetylases and dna methyltransferases. acts as transcriptional repressor and plays a role in gene silencing.
12815	
12816	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
12817	produces atp from adp in the presence of a proton gradient across the membrane.
12818	
12819	the alpha-v integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von willebrand factor. they recognize the sequence r-g-d in a wide array of ligands.
12820	serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. promotes neurite extension by inhibiting thrombin. binds heparin.
12821	enzyme involved in the biosynthesis of the e-selectin ligand, sialyl-lewis x. catalyzes the transfer of fucose from gdp- beta-fucose to alpha-2,3 sialylated substrates.
12822	
12823	probable catalytic subunit of a gtpase activating protein that has specificity for rab3 subfamily (rab3a, rab3b, rab3c and rab3d). rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. specifically converts active rab3-gtp to the inactive form rab3-gdp. required for normal eye and brain development. may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and nonsynaptic vesicular release of neurotransmitters.
12824	transports the calcitonin gene-related peptide type 1 receptor (calcrl) to the plasma membrane. acts as a receptor for calcitonin-gene-related peptide (cgrp) together with calcrl.
12825	adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates.
12826	
12827	mediates odorant detection (possibly) via modulation of intracellular camp concentration.
12828	
12829	catalyzes the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. may be involved in the activation of carcinogenic hyroxylamines. shows activity towards p-nitrophenol and n-hydroxy-2-acetylamino- fluorene (n-oh-2aaf).
12830	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
12831	mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient.
12832	
12833	inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. inhibins appear to oppose the functions of activins.
12834	may be involved in transcriptional regulation.
12835	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
12836	
12837	
12838	
12839	
12840	possibly involved in helper t-cell function.
12841	
12842	
12843	pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters. subunit of a quaternary complex that plays a central role in epithelial cell polarization.
12844	may be involved in transcriptional regulation.
12845	
12846	cbf binds to the core site, 5@#$%&-pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, lck, il-3 and gm-csf promoters.
12847	
12848	
12849	
12850	
12851	
12852	
12853	
12854	
12855	
12856	ena/vasp proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodelling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. enah induces the formation of f-actin rich outgrowths in fibroblasts. acts syngeristically with baiap2alpha and downstream of ntn1 to promote filipodia formation. required for the actin-based mobility of listeria monocytogenes (by similarity).
12857	histone methyltransferase. specifically methylates lys-4 of histone h3, inducing di- and tri-methylation, but not monomethylation. plays an important role in transcriptional activation as a member of an rna polymerase complex.
12858	
12859	may have a role in gut contractility or in thymic development and regulation.
12860	binds gtp, gdp and gmp.
12861	may anchor basement membranes to the underlying connective tissue (by similarity).
12862	
12863	chemotactic activity for lymphocytes but not for monocytes or neutrophils.
12864	may play a role in cell-cell recognition and signaling.
12865	also functions as a glutathione peroxidase.
12866	troponin i is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin atpase activity.
12867	
12868	3beta-hsd is a bifunctional enzyme, that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. the 3beta-hsd enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
12869	
12870	
12871	
12872	serine/threonine protein kinase involved in regulating m phase functions during the cell cycle. may also be part of the signaling network controlling cellular adhesion. in vitro, is able to phosphorylate cdc25c and casein.
12873	transcription factor which binds specifically to the mef2 element present in the regulatory regions of many muscle- specific genes. activates transcription via this element. may be involved in muscle-specific and/or growth factor-related transcription.
12874	
12875	stimulates guanine nucleotide exchange of rac and rho but is inactive toward cdc42, tc10, or ras. binds to rac and rho proteins in both the gdp- and guanosine 5@#$%&-3-o-(thio)triphosphate- bound states without detectable affinity for cdc42 or ras. may have a direct role in activation of rac and/or rho and in bringing the activated gtpase to specific target sites such as microtubules.
12876	
12877	acts upon elastin.
12878	binds the poly(a) tail of mrna. may be involved in cytoplasmic regulatory processes of mrna metabolism. can probably bind to cytoplasmic rna sequences other than poly(a) in vivo (by similarity).
12879	
12880	potently contract gastrointestinal (gi) smooth muscle. induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. has little or no effect on a variety of other endothelial and non-endothelial cell types.
12881	induces morphological reversion of a cell line transformed by a ras oncogene. counteracts the mitogenic function of ras, at least partly because it can interact with ras gaps and raf in a competitive manner.
12882	not known.
12883	
12884	amp deaminase plays a critical role in energy metabolism.
12885	
12886	
12887	involved in the inactivation of map kinases. has a specificity for the mapk11/mapk12/mapk13/mapk14 subfamily.
12888	
12889	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (by similarity).
12890	
12891	receptor for tnfsf14/4-1bbl. possibly active during t cell activation.
12892	has antiproliferative properties in human melanoma cells and may contribute to terminal cell differentiation. may also function as a negative regulator of melanoma progression. formation in vivo in nude mice. they found that it selectively induces apoptosis in human breast cancer cells.
12893	possible candidate as a tumor suppressor gene of neuroblastoma. may play an important role in preventing cells from entering the final stage (g1/s) of the transformation process.
12894	
12895	
12896	
12897	seems to play a role in the development or function of the kidney glomerular filtration barrier. may anchor the podocyte slit diaphragm to the actin cytoskeleton.
12898	
12899	this enzyme participates in both the breakdown and synthesis of glucose.
12900	
12901	
12902	
12903	desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
12904	responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-coa carboxylase. it also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-coa reductase. appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular atp levels are depleted and when 5@#$%&-amp rises in response to fuel limitation and/or hypoxia. this is a catalytic subunit.
12905	
12906	a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. in complex with slc9a3r1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. may play a role in the cellular mechanisms associated with multidrug resistance through its interaction with abcc2 and pdzk1ip1. may potentiate the cftr chloride channel activity. may function to connect scarb1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. may be involved in the regulation of proximal tubular na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (by similarity).
12907	binds medium- and long-chain acyl-coa esters with very high affinity and may function as an intracellular carrier of acyl-coa esters (by similarity). may be involved in energy metabolism in a manner that depends on the substrate used for energy production. dbi and its metabolites are involved in the regulation of multiple biological processes.
12908	catalyzes the trans-addition of the three molecules of ipp onto dmapp to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
12909	may be involved in transcriptional regulation.
12910	catalyzes the trans-addition of the three molecules of ipp onto dmapp to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
12911	essential for recycling gmp and indirectly, cgmp.
12912	negatively regulates tgf-beta signaling.
12913	
12914	
12915	
12916	beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of g proteins. this receptor binds epinephrine and norepinephrine with approximately equal affinity.
12917	
12918	motor protein required for establishing a bipolar spindle. blocking of eg5 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.
12919	
12920	may act as a chaperone.
12921	tafs are components of the transcription factor iid (tfiid) complex, pcaf histone acetylase complex and tbp-free tafii complex (tftc). tafs components-tiifd are essential for mediating regulation of rna polymerase transcription. taf5/tafii100 interacts strongly with the histone h4-related taf6/tafii80 and the histone h3-related taf9/tafii31, as well as a stable complex comprised of both taf5/tafii80 and taf6/tafii31. apparently weaker interactions of taf5/tafii100 with tbp, taf1/tafii250, taf11/tafii28, and taf12/tafii20, but not taf7/tafii55, also have been observed.
12922	collagen type iv is specific for basement membranes. vital for embryonic development.
12923	
12924	may be involved in transcriptional regulation.
12925	catalyzes the reversible synthesis of acetylcholine (ach) from acetyl coa and choline at cholinergic synapses.
12926	essential bifunctional enzyme that catalyzes both the n- deacetylation and the n-sulfation of glucosamine (glcnac) of the glycosaminoglycan in heparan sulfate. modifies the glcnac-glca dissacharide repeating sugar backbone to make n-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. plays a role in determining the extent and pattern of sulfation of heparan sulfate.
12927	
12928	
12929	
12930	ligand for members of the frizzled family of seven transmembrane receptors. may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.
12931	
12932	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
12933	involved in the atp-dependent vesicular transport of biogenic amine neurotransmitters. pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. requisite for vesicular amine storage prior to secretion via exocytosis.
12934	
12935	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release. has anti-apoptotic activity.
12936	acid protease active in intracellular protein breakdown. involved in the pathogenesis of several diseases such as breast cancer and possibly alzheimer disease.
12937	
12938	
12939	the substrate transported is not yet known. induces mitochondrial depolarization.
12940	involved in the repair of uv-damaged dna. binds to pyrimidine dimers.
12941	
12942	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
12943	acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.
12944	phosphorylase is an important allosteric enzyme in carbohydrate metabolism. enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. however, all known phosphorylases share catalytic and structural properties.
12945	
12946	
12947	
12948	
12949	may be involved in brain development during embryogenesis.
12950	
12951	
12952	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. has angiogenic inhibitor activity (by similarity). active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture (by similarity).
12953	degrades casein, gelatins of types i, iii, iv, and v, and fibronectin. activates procollagenase.
12954	
12955	
12956	
12957	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
12958	
12959	
12960	
12961	may play a role in vesicular protein sorting, similar to the yeast retromer proteins (by similarity).
12962	
12963	sodium-independent, high affinity transport of large neutral amino acids. has narrower substrate selectivity compared to slc7a5 and slc7a8 and mainly transports branched-chain amino acids and phenylalanine. plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.
12964	
12965	
12966	
12967	
12968	involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
12969	
12970	collagen type iii occurs in most soft connective tissues along with type i collagen.
12971	tumor suppressor that may be involved in interferon- dependent cell death (by similarity).
12972	
12973	may be involved in transcriptional regulation.
12974	
12975	could be involved in the hypothalamic regulation of body weight.
12976	binds to the basic helix-loop-helix protein tal-1. this interaction seems to be critical for the regulation of red blood cell development.
12977	gamma chains make up the fetal hemoglobin f, in combination with alpha chains.
12978	
12979	possible adhesion molecule with a role in early hematopoiesis by mediating attachment to stromal cells. influences the survival and/or proliferation of b-cell precursors. binding to cells requires mn(2+) (by similarity).
12980	
12981	
12982	
12983	
12984	xenin stimulates exocrine pancreatic secretion. it inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. in the gut, xenin interacts with the neurotensin receptor.
12985	participates in signal transduction in hematopoietic cells. adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. acts as an e3 ubiquitin-protein ligase, which accepts ubiquitin from specific e2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. recognizes activated receptor tyrosine kinases, including pdgfa, egf and csf1, and terminates signaling.
12986	regulator of notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. probably acts both as a positive and negative regulator of notch, depending on the developmental and cell context (by similarity). functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the notch pathway via some ubiquitin ligase activity.
12987	atp-dependent 3@#$%&-5@#$%& dna helicase, component of the core- tfiih basal transcription factor, involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. acts by opening dna either around the rna transcription start site or the dna damage.
12988	ca(2+)-regulated actin-binding protein.
12989	
12990	required for the production of circadian rhythms. the biological cycle depends on the rhythmic formation and nuclear localization of the tim-per complex. light induces the degradation of tim, which promotes elimination of per. nuclear activity of the heterodimer coordinatively regulates per and tim transcription through a negative feedback loop. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition.
12991	positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (mrlc). it prevents mir-mediated mrlc ubiquitination and its subsequent proteasomal degradation.
12992	
12993	
12994	putative transcription factor involved in the generation of biological rhythms. activates cycling transcription of period (per) and timeless (tim) by binding to the e-box (3@#$%&-cacgtg-5@#$%&) present in their promoters. cyc mutants don@#$%&t display per and tim cycling, and are completely arrhythmic.
12995	
12996	lacks intrinsic gtpase activity. has a low affinity for gdp, and constitutively binds gtp. control rearrangements of the actin cytoskeleton. induces the rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.
12997	
12998	
12999	inhibitor of protein-phosphatase 1. this protein may be important in hormonal control of glycogen metabolism. hormones that elevate intracellular camp increase i-1 activity in many tissues. i-1 activation may impose camp control over proteins that are not directly phosphorylated by pka. following a rise in intracellular calcium, i-1 is inactivated by calcineurin (or pp2b). does not inhibit type-2 phosphatases.
13000	
13001	may be involved in cytokinesis, motility, and signal transduction (by similarity).
13002	
13003	
13004	transcription termination factor. binds to a 28 bp region within the trna(leu(uur)) gene at a position immediately adjacent to and downstream of the 16s rrna gene, this region comprises a tridecamer sequence critical for directing accurate termination. probably requires one or more components for termination activity.
13005	probable transcription regulator.
13006	
13007	receptor for the heterotrimeric lymphotoxin containing lta and ltb, and for tnfs14/light. promotes apoptosis via traf3 and traf5. may play a role in the development of lymphoid organs.
13008	
13009	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity).
13010	required for protein transport from the er to the golgi complex.
13011	negatively regulates map kinase activation by limiting the formation of raf/mek complexes probably by inactivation of the ksr1 scaffold protein. also acts as a ras responsive e3 ubiquitin ligase that, on activation of ras, is modified by auto- polyubiquitination resulting in the release of inhibition of raf/mek complex formation. may also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
13012	
13013	
13014	
13015	
13016	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
13017	
13018	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
13019	
13020	
13021	
13022	
13023	may mediate the control of various cellular processes by insulin.
13024	
13025	required for normal golgi function (by similarity).
13026	
13027	
13028	transcription factor that binds to gc box promoter elements. activates the transcription of these genes.
13029	
13030	
13031	
13032	may be involved in several stages of intracellular trafficking.
13033	
13034	
13035	
13036	
13037	
13038	
13039	
13040	binds to disheveled (dvl) and rho, and mediates wnt- induced dvl-rho complex formation. may play a role as a scaffolding protein to recruit rho-gdp and rho-gef, thereby, enhancing rho-gtp formation.
13041	induces cartilage and bone formation. also act in mesoderm induction, tooth development, limb formation and fracture repair.
13042	centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. may also act as a centrosome maturation factor. may play a role in microtubule nucleation. overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules.
13043	
13044	plays a role in transcriptional coactivation.
13045	transcription factor required for gene expression specific to photoreceptor cells.
13046	receptor for thyrothropin. plays a central role in controlling thyroid cell metabolism. the activity of this receptor is mediated by g proteins which activate adenylate cyclase. also acts as a receptor for thyrostimulin (gpa2+gpb5).
13047	this essential protein binds to polyadenylated rna and single-stranded dna. it may be involved not only in rna processing but also in transcription regulation. believed to associate directly with nascent rna polymerase ii transcripts and remain associated during subsequent nuclear rna processing reactions.
13048	high affinity receptor for sphingosylphosphorylcholine, coupled to g proteins that stimulate phosphoinositide hydrolysis.
13049	
13050	
13051	
13052	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna.
13053	
13054	
13055	
13056	thought to regulate cation conductance. may regulate accn1 and accn3 gating (by similarity).
13057	
13058	
13059	
13060	may function as an antagonist of fibroblast growth factor (fgf) pathways and may negatively modulate respiratory organogenesis.
13061	transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways (by similarity).
13062	
13063	
13064	may be involved in cell adhesion processes, particularly in the central nervous system.
13065	can phosphorylate the alpha subunit of eif2 and may mediate translational control (by similarity).
13066	transcriptional factor which uses the canonical single or multiple carg boxes dna sequence. acts as a cofactor of serum response factor (srf) and has the potential to modulate srf-target genes. suppresses tnf-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. it may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (by similarity).
13067	
13068	
13069	
13070	
13071	
13072	kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. binds to microtubules and to dna.
13073	subunit of the integral membrane v0 complex of vacuolar atpase. vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.
13074	
13075	adapter molecule for tnfrsf1a/tnfr1 that specifically associates with the cytoplasmic domain of activated tnfrsf1a/tnfr1 mediating its interaction with fadd. overexpression of tradd leads to two major tnf-induced responses, apoptosis and activation of nf-kappa-b.
13076	
13077	
13078	
13079	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
13080	
13081	collagen type ii is specific for cartilaginous tissues. it is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
13082	
13083	
13084	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
13085	proton-conducting pore forming subunit of the membrane integral v0 complex of vacuolar atpase. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
13086	may play a role in 60s ribosomal subunit synthesis (potential).
13087	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
13088	could be involved in the unfolded protein response (upr) pathway. could enhance presenilin-mediated beta-amyloid protein 40 generation.
13089	integrin alpha-l/beta-2 is a receptor for icam1, icam2, icam3 and icam4. it is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic t-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
13090	sodium-dependent glucose transporter (by similarity).
13091	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i (by similarity).
13092	
13093	
13094	hcnp may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. hcnp increases the production of choline acetyltransferase but not acetylcholinesterase. seems to be mediated by a specific receptor (by similarity).
13095	
13096	
13097	
13098	
13099	
13100	
13101	required for the accumulation of coenzyme a in the mitochondrial matrix.
13102	
13103	
13104	
13105	pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
13106	involved in axon growth. plays an essential role in neurite extension of cerebellar granule cells.
13107	
13108	
13109	component of the adaptor complexes which link clathrin to receptors in coated vesicles. clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. ap2b1 is a subunit of the plasma membrane adaptor. the complex binds polyphosphoinositides.
13110	may be a single membrane channel protein acting both as a hydrolase and a translocase. it is the key enzyme in homeostatic regulation of blood glucose levels.
13111	
13112	component of the u5 snrnp complex required for pre-mrna splicing. binds gtp. interacts with prpf8.
13113	seems to act as a scaffold protein in multiple signaling pathways. modulates excitatory synaptic transmission and dendritic spine morphology. binds to actin filaments (f-actin) and shows cross-linking activity. binds along the sides of the f-actin. may play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. believed to target protein phosphatase 1/pp1 to dendritic spines, which are rich in f-actin, and regulates its specificity toward ion channels and other substrates, such as ampa-type and nmda-type glutamate receptors. plays a role in regulation of g-protein coupled receptor signaling, including dopamine d2 receptors and alpha- adrenergic receptors. may establish a signaling complex for dopaminergic neurotransmission through d2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. binds to adra1b and rgs2 and mediates regulation of adra1b signaling. may confer to rac signaling specificity by binding to both, racgefs and rac effector proteins. probably regulates p70 s6 kinase activity by forming a complex with tiam1.
13114	integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and cspg4. alpha- 3/beta-1 may mediate with lgals3 the stimulation by cspg4 of endothelial cells migration.
13115	chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. may be involved in b-cell migration into b-cell follicles in lymph nodes. attracts naive t-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive t-cells, cd4+ and cd8+ t-cells and thus may play a role in both humoral and cell-mediated immunity responses.
13116	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
13117	
13118	
13119	may act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. may be involved in epidermal cell adhesion and epidermal structure and function.
13120	may play a role in the signal transduction pathway mediated by multiple wnt genes.
13121	
13122	converts arachidonic acid to 15s- hydroperoxyeicosatetraenoic acid. also acts on c-12 of arachidonate as well as on linoleic acid.
13123	
13124	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
13125	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
13126	may play a unique role in maintaining the normal corneal epithelial function (by similarity).
13127	receptor for adenosine. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
13128	
13129	nucleolin is the major nucleolar protein of growing eukaryotic cells. it is found associated with intranucleolar chromatin and preribosomal particles. it induces chromatin decondensation by binding to histone h1. it is thought to play a role in pre-rrna transcription and ribosome assembly.
13130	responsible for methylating the 5@#$%&cap structure of mrnas.
13131	
13132	
13133	
13134	
13135	
13136	may be involved in transcriptional regulation.
13137	specialized low-affinity urea transporter. mediates urea transport in erythrocytes.
13138	may act as a protease inhibitor to modulate the host immune response against tumor cells.
13139	
13140	low affinity receptor to n-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. binding of fmlp to the receptor causes activation of neutrophils. this response is mediated via a g-protein that activates a phosphatidylinositol-calcium second messenger system. the activation of lxa4r could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as ltb4 (leukotriene b4).
13141	
13142	may be involved in transcriptional regulation.
13143	stimulates promoter activity in the presence of p49- and p50-nf-kappa-b. neither associates with dna nor with p65-nf-kappa- b.
13144	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
13145	
13146	
13147	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
13148	exhibits a coumarin 7-hydroxylase activity. active in the metabolic activation of hexamethylphosphoramide, n,n- dimethylaniline, 2@#$%&-methoxyacetophenone, n- nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone.
13149	
13150	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
13151	component of the 60-80s u3 small nucleolar ribonucleoprotein (u3 snornp). required for the early cleavages during pre-18s ribosomal rna processing.
13152	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
13153	
13154	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
13155	binds to the fc region of monomeric immunoglobulins gamma. mediates the uptake of igg from milk. possible role in transfer of immunoglobulin g from mother to fetus.
13156	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
13157	
13158	required for vesicular transport between the endoplasmic reticulum and the golgi apparatus.
13159	has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. it accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. act as a cell surface receptor for feline endogenous virus rd114, baboon m7 endogenous virus and type d simian retroviruses.
13160	docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. dok1 appears to be a negative regulator of the insulin signaling pathway.
13161	could have a regulatory function in meiosis.
13162	troponin t is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin atpase activity.
13163	suppressor of clathrin deficiency.
13164	
13165	docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. dok1 appears to be a negative regulator of the insulin signaling pathway.
13166	
13167	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling (by similarity).
13168	plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. binds to the photoreceptor conserved element-i (pce-1/ret 1) in the photoreceptor cell-specific arrestin promoter (by similarity).
13169	plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. binds to the photoreceptor conserved element-i (pce-1/ret 1) in the photoreceptor cell-specific arrestin promoter (by similarity).
13170	
13171	plays a role in transcriptional coactivation. plays a role in nuclear hormone receptor-mediated transactivation.
13172	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
13173	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
13174	cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. may be involved in nervous system development.
13175	
13176	binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer.
13177	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
13178	
13179	
13180	transcriptional repressor.
13181	this protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.
13182	mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. also required for the transfer of beta-barrel precursors from the tom complex to the sorting and assembly machinery (sam complex) of the outer membrane. acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. the timm8-timm13 complex mediates the import of proteins such as timm23, slc25a12/aralar1 and slc25a13/aralar2, while the predominant timm9-timm10 70 kda complex mediates the import of much more proteins.
13183	
13184	
13185	
13186	camp-dependent and sulfonylurea-sensitive anion transporter. key gatekeeper influencing intracellular cholesterol transport.
13187	
13188	
13189	
13190	
13191	involved in rna polymerase iii-mediated transcription. integral, tightly associated component of the dna-binding tfiiic2 subcomplex that directly binds trna and virus-associated rna promoters.
13192	integrins alpha-4/beta-1 (vla-4) and alpha-4/beta-7 are receptors for fibronectin. they recognize one or more domains within the alternatively spliced cs-1 and cs-5 regions of fibronectin. they are also receptors for vcam1. integrin alpha- 4/beta-1 recognizes the sequence q-i-d-s in vcam1. integrin alpha- 4/beta-7 is also a receptor for madcam1. it recognizes the sequence l-d-t in madcam1. on activated endothelial cells integrin vla-4 triggers homotypic aggregation for most vla-4-positive leukocyte cell lines. it may also participate in cytolytic t-cell interactions with target cells.
13193	may have a function in migrating cells.
13194	
13195	stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. active in the presence of nad as cofactor but not in the presence of nadp.
13196	
13197	
13198	
13199	plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. sequence-specific dna-binding protein with a distinct binding specificity.
13200	receptor for interleukin-1 alpha (il-1a), beta (il-1b), and interleukin-1 receptor antagonist protein (il-1ra). binding to the agonist leads to the activation of nf-kappa-b. signaling involves formation of a ternary complex containing il1rap, tollip, myd88, and irak1 or irak2.
13201	
13202	involved in the degradation of prenylated proteins. cleaves the thioether bond of prenyl-l-cysteines, such as farnesylcysteine and geranylgeranylcysteine.
13203	
13204	induces growth and cell cycle arrests at the g1 phase of the cell cycle.
13205	this protein is one of the chains of the nonenzymatic membrane component (f0) of mitochondrial atpase.
13206	
13207	
13208	inactivates histamine by n-methylation. plays an important role in degrading histamine and in regulating the airway response to histamine.
13209	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
13210	may have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.
13211	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
13212	
13213	acts on tyrosine phosphorylated proteins, low-mw aryl phosphates and natural and synthetic acyl phosphates. isoform 3 does not possess phosphatase activity.
13214	
13215	
13216	
13217	atp-dependent rna helicase involved in 40s ribosomal subunit biogenesis. required for the processing and cleavage of 35s pre-rrna at sites a0, a1, and a2, leading to mature 18s rrna.
13218	
13219	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
13220	catalyzes the cleavage of l-kynurenine (l-kyn) and l-3- hydroxykynurenine (l-3ohkyn) into anthranilic (aa) and 3- hydroxyanthranilic acids (3-ohaa), respectively. has a preference for the l-3-hydroxy form. also has cysteine-conjugate-beta-lyase activity (by similarity).
13221	may convert the inactive conformation of integrin alpha- iib/beta3 to an active form through the binding to the integrin cytoplasmic domain.
13222	
13223	
13224	proto-oncogene that may play a role in differentiation and lymphopoiesis. may function as a transcriptional transactivator.
13225	acts at e2f-responsive promoters to integrate signals provided by phd- and/or bromodomain-containing transcription factors (by similarity).
13226	
13227	phosphorylates khdrbs1, khdrbs2, khdrbs3 and stap2/bks. may function as an intracellular signal transducer in epithelial tissues. overexpression in mammary cells leads to mitogenically sensitization to egf, and results in a partially transformed phenotype. its presence in the nucleus appears to be linked to suppression of tumor progression.
13228	
13229	
13230	
13231	plays a role in the import of cytosolically synthesized preproteins into mitochondria. binds the mature portion of precursor proteins. interacts with cellular components, and possesses weak atpase activity. may be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.
13232	receptor for tnfsf5/cd40lg.
13233	
13234	
13235	facilitative glucose transporter. this isoform may be responsible for constitutive or basal glucose uptake. has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
13236	catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. it is responsible for the later stages of cell envelope formation in the epidermis and the hair follicle.
13237	
13238	secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
13239	
13240	initiates extracellular glutathione (gsh) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular gsh level. it is part of the cell antioxidant defense mechanism. catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. alternatively, glutathione can be hydrolyzed to give cys-gly and gamma glutamate.
13241	may have the capacity of recognizing and binding specific classes of odorants, may act as carrier molecules, transporting odorants across the mucus layer to access the receptor sites. may serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing the excess odorant from the mucus to enable new odorant stimuli to be received (by similarity).
13242	adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. may link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. plays an important role in synapse formation and in the organization of utrn and acetylcholine receptors at the neuromuscular synapse. binds to phosphatidylinositol 4,5-biphosphate (by similarity).
13243	
13244	
13245	receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5), susceptibility to infection is correlated to its level of expression and availability at the plasma membrane of cells.
13246	
13247	
13248	
13249	complex that is thought to mediate chromatin assembly in dna replication and dna repair. assembles histone octamers onto replicating dna in vitro. caf-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones h3 and h4 to replicating dna; histones h2a/h2b can bind to this chromatin precursor subsequent to dna replication to complete the histone octamer. the ccr4-not complex functions as general transcription regulation complex.
13250	
13251	transcriptional regulator. may participate in transcriptional regulation through the recruitment of setdb1 histone methyltransferase and subsequent modification of local chromatin structure.
13252	an integral component of the pericentriolar material (pcm).
13253	inhibits gastrointestinal motility and gastric acid secretion. could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (by similarity).
13254	
13255	required for initiation of chromosomal dna replication.
13256	
13257	probable transcriptional regulator that may play a crucial role in embryogenesis.
13258	dephosphorylates and concomitantly deactivates cam- kinase ii activated upon autophosphorylation, and cam-kinases iv and i activated upon phosphorylation by cam-kinase kinase. promotes apoptosis.
13259	may play an important role in the progression of epithelial malignancies.
13260	binds 7-ketocholesterol.
13261	
13262	sodium-dependent glucose transporter (by similarity).
13263	
13264	
13265	may have transport activity.
13266	
13267	type i collagen is a member of group i collagen (fibrillar forming collagen).
13268	
13269	
13270	
13271	may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
13272	
13273	tumor suppressor that may be involved in interferon- dependent cell death (by similarity).
13274	
13275	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
13276	
13277	
13278	
13279	
13280	might be involved in transcellular transport (by similarity).
13281	
13282	
13283	may function in membrane trafficking. exhibits calcium- dependent phospholipid binding properties (by similarity).
13284	
13285	
13286	transcriptional regulator that probably plays an important role in lymphomagenesis.
13287	involved in the hydrolysis of n-acylated or n-acetylated amino acids (except l-aspartate).
13288	
13289	
13290	hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. displays very low levels of activity. associates with and negatively regulates mst1r.
13291	specifically binds poly(g) rna homopolymers in vitro.
13292	visual pigments are the light-absorbing molecules that mediate vision. they consist of an apoprotein, opsin, covalently linked to cis-retinal.
13293	receptor for sema4d. plays a role in rhoa activation and subsequent changes of the actin cytoskeleton. plays a role in axon guidance, invasive growth and cell migration.
13294	
13295	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
13296	
13297	
13298	activates the jun n-terminal pathway through activation of the map kinase kinase map2k7. acts synergistically with prdx3 to regulate the activation of nf-kappa-b in the cytosol. this activation is kinase-dependent and involves activating the ikk complex, the ikbkb-containing complex that phosphorylates inhibitors of nf-kappa-b.
13299	hydrolysis of urea to ammonia and co2.
13300	
13301	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
13302	
13303	activates hepatocyte growth factor (hgf) by converting it from a single chain to a heterodimeric form.
13304	
13305	
13306	
13307	
13308	the enzyme cleaves lys-arg and arg-ser bonds. it activates, in a reciprocal reaction, factor xii after its binding to a negatively charged surface. it also releases bradykinin from hmw kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
13309	component of the elastin-associated microfibrils.
13310	binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. only a small percentage (less than 2%) of the human afp shows estrogen-binding properties.
13311	stimulates gdp/gtp exchange reaction of a group of small gtp-binding proteins (g proteins) including rap1a/rap1b, rhoa, rhob and kras, by stimulating the dissociation of gdp from and the subsequent binding of gtp to each small g protein.
13312	
13313	removes residual c-terminal arg or lys remaining after initial endoprotease cleavage during prohormone processing. processes proinsulin.
13314	
13315	required for ribosome biogenesis. part of a complex which catalyzes pseudouridylation of rrna. this involves the isomerization of uridine such that the ribose is subsequently attached to c5, instead of the normal n1. pseudouridine (@#$%!psi@#$%!) residues may serve to stabilize the conformation of rrnas. essential for growth.
13316	
13317	may be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
13318	essential for the control of the cell cycle at the g1/s (start) and the g2/m (mitosis) transitions.
13319	
13320	binds with high affinity to rna molecules that contain au-rich elements (ares) found within the 3-prime untranslated regions of many protooncogenes and cytokine mrnas. also binds to double- and single-stranded dna sequences in a specific manner and functions a transcription factor. each of the rna-binding domains specifically can bind solely to a single-stranded non-monotonous 5@#$%&-uuag-3@#$%& sequence and also weaker to the single-stranded 5@#$%&- ttaggg-3@#$%& telomeric dna repeat. binding of rrm1 to dna inhibits the formation of dna quadruplex structure which may play a role in telomere elongation. may be involved in translationally coupled mrna turnover. implicated with other rna-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding-region determinant of instability (mcrd) domain.
13321	
13322	may have a role in spermatogenesis.
13323	
13324	
13325	udpgts are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. this isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. it also catalyzes the glucuronidation of endogenous estrogens and androgens.
13326	receptor for vegf or vegfc. has a tyrosine-protein kinase activity. the vegf-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.
13327	collagen type iv is specific for basement membranes. vital for embryonic development.
13328	
13329	
13330	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
13331	
13332	initiates complex n-linked carbohydrate formation. essential for the conversion of high-mannose to hybrid and complex n-glycans.
13333	
13334	
13335	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
13336	involved in transcription.
13337	specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3@#$%&end of 16s rrna in the 30s particle. its inactivation leads to kasugamycin resistance.
13338	
13339	has a transcriptional repressor activity. induces apoptosis by activating jun n-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. may function in male germ cell development. has dna-binding activity and preferentially bound to double- stranded dna (by similarity).
13340	may act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
13341	regulator of vesicular trafficking process. required for the sorting of endocytic (egf receptors) cargos. also involved in exocytic cargos of viral proteins of hiv-1 virus. in case of infection by hiv-1 virus, it is recruited to and functions at sites of viral gag assembly and budding. may be involved in cell growth and differentiation. acts as a negative growth regulator.
13342	
13343	may play a role in growth regulation. is associated with g2/m phase arrest in response to dna damage. may be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (by similarity).
13344	
13345	
13346	may play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.
13347	associates with the cytoplasmic domain of a variety of cadherins. the association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. may play a crucial role in cell differentiation.
13348	
13349	
13350	
13351	beta-endorphin and met-enkephalin are endogenous opiates.
13352	integrin alpha-1/beta-1 is a receptor for laminin and collagen. it recognizes the proline-hydroxylated sequence g-f-p-g- e-r in collagen.
13353	could play a role in the terminal differentiation of the intestine.
13354	
13355	may function as a nuclear transport receptor (by similarity).
13356	receptor for trypsin and trypsin-like enzymes coupled to g proteins that stimulate phosphoinositide hydrolysis. may have a role in the regulation of vascular tone.
13357	
13358	involved in the transport of chloride ions. may regulate bicarbonate secretion and salvage in epithelial cells by regulating the slc4a7 transporter.
13359	
13360	transports cmp-sialic acid from the cytosol into golgi vesicles where glycosyltransferases function.
13361	
13362	
13363	the enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin k-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
13364	converts lysophosphatidic acid (lpa) into phosphatidic acid by incorporating acyl moiety at the 2 position (by similarity).
13365	
13366	
13367	involved in the biosynthesis of molybdopterin precursor z from guanosine.
13368	involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with mhc class i molecules. also acts as a molecular scaffold for the final stage of mhc class i folding, namely the binding of peptide. nascent mhc class i molecules associate with tap via tapasin. inhibited by the covalent attachment of herpes simplex virus icp47 protein, which blocks the peptide-binding site of tap. inhibited by human cytomegalovirus us6 glycoprotein, which binds to the lumenal side of the tap complex and inhibits peptide translocation by specifically blocking atp-binding to tap1 and prevents the conformational rearrangement of tap induced by peptide binding. inhibited by human adenovirus e3-19k glycoprotein, which binds the tap complex and acts as a tapasin inhibitor, preventing mhc class i/tap association. expression of tap1 is down-regulated by human epstein-barr virus vil-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by mhc class i molecules.
13369	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
13370	
13371	
13372	
13373	putative odorant receptor.
13374	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
13375	
13376	
13377	transcription factor that binds to the octamer motif (5@#$%&-atttgcat-3@#$%&). prime candidate for an early developmental control gene.
13378	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
13379	transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. binds dna on the 5@#$%&-ccac[ga]-3@#$%&half of the er stress response element (erse) (5@#$%&-ccaat-n(9)-ccac[ga]-3@#$%&) and of erse ii (5@#$%&-attgg-n-ccacg-3@#$%&). binding to erse requires binding of nf-y to erse. could also be involved in activation of transcription by the serum response factor.
13380	
13381	nuclear hormone receptor. involved in the retinoic acid response pathway. binds 9-cis retinoic acid (9c-ra).
13382	this protein is associated with snrnp u1.
13383	core tafii present in both of the previously described tfiid species which either lack or contain tafii30 (tfiid alpha and tfiid beta respectively).
13384	may be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to dna damage. binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
13385	
13386	
13387	
13388	
13389	probable transcriptional regulator.
13390	transcription factor that binds specifically to the distal ras-responsive element (rre) in the calcitonin gene promoter and augment the ras/raf-mediated transcriptional response of that promoter. may be involved in ras/raf-mediated cell differentiation.
13391	
13392	may be involved in the control of camp-mediated neural activity and camp metabolism in the brain.
13393	required for imaginal cell differentiation, may be involved in hormonal responsiveness during metamorphosis. involved in an inhibitory signaling mechanism to determine the number of cells that will form unicellular sprouts in the trachea. regulated by transcription factor esg. the longer hdc protein is completely functional and the shorter protein carries some function.
13394	
13395	id (inhibitor of dna binding) hlh proteins lack a basic dna-binding domain but are able to form heterodimers with other hlh proteins, thereby inhibiting dna binding.
13396	
13397	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules (by similarity).
13398	
13399	probable motor protein.
13400	
13401	
13402	sugar transporter that specifically mediates the transport of udp-xylose (udp-xyl) and udp-n-acetylglucosamine (udp-glcnac) from cytosol into golgi.
13403	sugar transporter that specifically mediates the transport of udp-xylose (udp-xyl) and udp-n-acetylglucosamine (udp-glcnac) from cytosol into golgi.
13404	
13405	
13406	may be involved in transcriptional regulation.
13407	arm and abl proteins function cooperatively at adherens junctions in both the cns and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone@#$%&s response to midline cues. the ability of pcc/mp2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both slit/robo and abl-dependent signaling pathways.
13408	
13409	
13410	
13411	
13412	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
13413	
13414	
13415	involved in regulation of adherens junction between cells. functions as a guanine nucleotide exchange factor (gef), which activates rap1 small gtpase by exchanging bound gdp for free gtp.
13416	
13417	essential component of the scf (skp1-cul1-f-box protein) e3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. in the scf complex, serves as a rigid scaffold that organizes the skp1-f-box protein and rbx1 subunits. may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
13418	
13419	participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
13420	plays an important role in the differentiation and development of pancreatic islet beta cells. transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. competes with pax6 for this same promoter binding site. the pax4v isoform appears to be a dominant negative form antagonizing pax4 transcriptional activity.
13421	required for vesicular transport from the er to the golgi complex. functions as a snare involved in the docking process of er-derived vesicles with the cis-golgi membrane (by similarity).
13422	
13423	
13424	
13425	
13426	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
13427	
13428	
13429	
13430	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters.
13431	
13432	converts hdl into larger and smaller particles. may play a key role in extracellular phospholipid transport and modulation of hdl particles.
13433	
13434	stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. may bind polyunsaturated fatty acids.
13435	high specificity for fatty acids. highest affinity for c18 chain length. decreasing the chain length or introducing double bonds reduces the affinity. may be involved in keratinocyte differentiation.
13436	
13437	general coactivator that functions cooperatively with tafs and mediates functional interactions between upstream activators and the general transcriptional machinery. binds single-stranded dna.
13438	promotes guanine-nucleotide exchange on arf1, arf5 and arf6. promotes the activation of arf1/arf5/arf6 through replacement of gdp with gtp.
13439	negatively regulates tyrosine hydroxylase activity.
13440	
13441	
13442	may play a role in the apoptotic pathway or cell-cycle regulation induced by p53 after dna damage.
13443	
13444	
13445	
13446	
13447	
13448	protein kinase that plays an important role in cellular stress response. activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic foxo3a. phosphorylates nedd4l, which leads to its inactivation and to the subsequent activation of various channels and transporters such as enac, kv1.3, or eaat1.
13449	the elongin bc complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different e3 ubiquitin ligase complexes, including the von hippel-lindau ubiquitination complex cbc(vhl). by binding to bc- box motifs it seems to link target recruitment subunits, like vhl and members of the socs box family, to cullin/rbx1 modules that activate e2 ubiquitination enzymes.
13450	forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (by similarity).
13451	binds to tie2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. its function may be context-dependent. in the absence of angiogenic inducers, such as vegf, ang2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. in concert with vegf, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
13452	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
13453	
13454	
13455	member of the machinery of polarized transport. required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.
13456	
13457	
13458	
13459	
13460	possible morphogenic cytoskeletal element in spermiogenic differentiation.
13461	
13462	adf augments the expression of the interleukin-2 receptor tac (il2r/p55).
13463	
13464	
13465	involved in dna excision repair. initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region.
13466	required for the binding of mrna to ribosomes. functions in close association with eif4-f and eif4-a. binds near the 5@#$%&- terminal cap of mrna in presence of eif-4f and atp. promotes the atpase activity and the atp-dependent rna unwinding activity of both eif4-a and eif4-f.
13467	induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
13468	
13469	
13470	
13471	
13472	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain (by similarity).
13473	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
13474	transcriptional coactivator stimulating nr5a1 and ligand-dependent nr1h3/lxra and pparg transcriptional activities. enhances the dna-binding activity of atf1, atf2, creb1 and nr5a1. regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. may function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
13475	functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. upon ligand activation through the released notch intracellular domain (nicd) it forms a transcriptional activator complex with rbp-j kappa and activates genes of the enhancer of split locus. affects the implementation of differentiation, proliferation and apoptotic programs. may be important for normal lymphocyte function. in altered form, may contribute to transformation or progression in some t-cell neoplasms. involved in the maturation of both cd4+ and cd8+ cells in the thymus (by similarity).
13476	probable atp-dependent rna helicase (by similarity).
13477	
13478	
13479	
13480	co-chaperone of hsc70. seems to play a role in protein import into mitochondria.
13481	required for protein transport from the er to the golgi complex.
13482	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
13483	
13484	probably involved in iron homeostasis.
13485	
13486	involved in pre-mrna splicing.
13487	
13488	involved in the synthesis of the gdp-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
13489	
13490	
13491	clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
13492	converts arachidonic acid exclusively to 15s- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized.
13493	
13494	protein kinase that act on both serine and threonine residues.
13495	
13496	
13497	
13498	
13499	may antagonize nodal signaling and subsequent organization of axial structures during mesodermal patterning (by similarity).
13500	
13501	responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-coa carboxylase. it also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-coa reductase. appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular atp levels are depleted and when 5@#$%&-amp rises in response to fuel limitation and/or hypoxia. this is a catalytic subunit.
13502	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
13503	hydrolyzes both cyclic amp (camp) and cyclic gmp (cgmp) (by similarity).
13504	
13505	
13506	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
13507	
13508	
13509	required for tcr (t-cell antigen receptor)- and pre-tcr- mediated signaling, both in mature t-cells and during their development. involved in fcgr3 (low affinity immunoglobulin gamma fc region receptor iii)-mediated signaling in natural killer cells and fcer1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, pkc activation, mapk activation or cytoskeletal reorganization through the recruitment of plcg1, grb2, grap2, and other signaling molecules.
13510	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
13511	
13512	
13513	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
13514	
13515	stimulates a migratory response in cd4+ lymphocytes, monocytes, and eosinophils. also induces t-lymphocyte expression of interleukin 2 receptor. ligand for cd4.
13516	
13517	plays a role in membrane trafficking and in homotypic early endosome fusion.
13518	
13519	
13520	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form.
13521	
13522	
13523	
13524	
13525	nuclear hormone receptor. the steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
13526	
13527	
13528	the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the er, via the golgi up to the trans golgi network. coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-er transport of dilysine-tagged proteins. in mammals, the coatomer can only be recruited by membranes associated to adp-ribosylation factors (arfs), which are small gtp-binding proteins; the complex also influences the golgi structural integrity, as well as the processing, activity, and endocytic recycling of ldl receptors (by similarity).
13529	this protein is a transcriptional activator. it may play a role in the formation of segmented structures of the embryo. may play an important role in the normal development of the vertebral column (by similarity).
13530	
13531	plays a role in signal transduction in blood cells. contributes to both cell proliferation and survival and thus provide a selective advantage in tumorigenesis.
13532	signaling adapter that couples activated growth factor receptors to signaling pathway. isoform p46shc and isoform p52shc, once phosphorylated, couple activated receptor tyrosine kinases to ras via the recruitment of the grb2/sos complex and are implicated in the cytoplasmic propagation of mitogenic signals. isoform p46shc and isoform p52shc may thus function as initiators of the ras signaling cascade in various nonneuronal systems. isoform p66shc does not mediate ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. isoform p66shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. the expression of isoform p66shc has been correlated with life span (by similarity).
13533	has an important function as a repair enzyme for proteins that have been inactivated by oxidation. catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
13534	accepts electrons from etf and reduces ubiquinone.
13535	
13536	
13537	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
13538	this receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. it phosphorylates the insulin receptor substrates irs-1 and irs-2.
13539	
13540	ionotropic receptor with a probable role in the modulation of auditory stimuli. agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. the channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. in the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. this may protect against acoustic trauma. may also regulate keratinocyte adhesion.
13541	shows weak transcriptional activatory activity.
13542	
13543	this protein has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. seems to be identical to the elastin-binding protein (ebp), a major component of the non- integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. in elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.
13544	this protein has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. seems to be identical to the elastin-binding protein (ebp), a major component of the non- integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. in elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.
13545	
13546	involved in the pathway that functions to remove an inhibitor (probably synaptotagmin iv) of calcium-triggered exocytosis during the maturation of secretory granules. may be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.
13547	
13548	
13549	tyrosine kinase, that after binding to cdc42, inhibits both its intrinsic and stimulated gtpase activity.
13550	
13551	plasma membrane t-snare that mediates docking of transport vesicles. necessary for the translocation of slc2a4 from intracellular vesicles to the plasma membrane. may also play a role in docking of synaptic vesicles at presynaptic active zones.
13552	
13553	mediates electroneutral potassium-chloride cotransport when activated by cell swelling. may mediate k(+) uptake into deiters@#$%& cells in the cochlea and contribute to k+ recycling in the inner ear. important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of corti. may be required for basolateral cl(-) extrusion in the kidney and contribute to renal acidification (by similarity).
13554	
13555	phosphorylates on ser and thr residues the goodpasture autoantigen (in vitro). isoform 2 seems to be less active.
13556	direct ligand for the erbb4 tyrosine kinase receptor. binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. does not bind to the egf receptor, erbb2 or erbb3 receptors.
13557	
13558	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&. activates transcription of pf4 in complex with meis1.
13559	
13560	
13561	
13562	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes, such as ube2l3/ubcm4, and then transfers it to substrates.
13563	
13564	
13565	
13566	may regulate transcriptional activity.
13567	vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
13568	type i collagen is a member of group i collagen (fibrillar forming collagen).
13569	adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. can bind to fibrinogen, fibronectin, laminin and type v collagen.
13570	receptor that may play a role in the perception of bitterness and is gustducin-linked. may play a role in sensing the chemical composition of the gastrointestinal content. the activity of this receptor may stimulate alpha gustducin, mediate plc-beta-2 activation and lead to the gating of trpm5 (by similarity).
13571	transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. it appears that leucine is the preferred substrate, but all large neutral non-aromatic l-amino acids bind to this transporter. uptake of leucine is sodium- dependent. in contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (by similarity).
13572	acts as a molecular chaperone for pcsk2/pc2, preventing its premature activation in the regulated secretory pathway. binds to inactive pcsk2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. also required for cleavage of pcsk2 but does not appear to be involved in its folding. plays a role in regulating pituitary hormone secretion. the c-terminal peptide inhibits pcsk2 in vitro.
13573	
13574	complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. also mediates erythropoiesis in vitro; but, unlike il-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. known to act on mmp-1, mmp-2, mmp-3, mmp-7, mmp-8, mmp-9, mmp-10, mmp-11, mmp-12, mmp-13 and mmp-16. does not act on mmp-14.
13575	dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. could be involved in a signal transduction pathway necessary for late myogenesis, although its ubiquitous expression suggests a wider function.
13576	dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. could be involved in a signal transduction pathway necessary for late myogenesis, although its ubiquitous expression suggests a wider function.
13577	may suppress the ability of pou3f2 to transactivate the drd1 gene in a pou3f2 dependent manner. can activate transcription directly or via association with the transcription machinery. may be involved in atxn1 mutant-induced cell death. the interaction with atxn1 mutant reduces levels of phosphorylated rna polymerase ii large subunit.
13578	
13579	
13580	
13581	possibly involved in membrane-cytoskeleton interactions of the central nervous system.
13582	mediates b-cell proliferation in the absence of co- stimulus as well as ige production in the presence of il-4. involved in immunoglobulin class switching.
13583	
13584	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
13585	receptor for gastrin releasing peptide (grp). this receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system.
13586	
13587	could be a global transcriptional regulator. modifies gene expression by affecting chromatin (potential).
13588	
13589	
13590	
13591	
13592	
13593	may eliminate potentially toxic dinucleoside polyphosphates during sporulation. most active against diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p6-hexaphosphate (ap6a). can also hydrolyze diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p5-pentaphosphate (ap5a), adenosine 5@#$%&-pentaphosphate, and adenosine 5@#$%&-tetraphosphate are also substrates, but not diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p4-tetraphosphate (ap4a) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. also cleaves a beta-phosphate from the diphosphate groups in pp-insp5 (diphosphoinositol pentakisphosphate) and [pp]2-insp4 (bisdiphosphoinositol tetrakisphosphate).
13594	
13595	
13596	probable transcriptional activator.
13597	
13598	functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. upon ligand activation through the released notch intracellular domain (nicd) it forms a transcriptional activator complex with rbp-j kappa and activates genes of the enhancer of split locus. affects the implementation of differentiation, proliferation and apoptotic programs (by similarity). may play a role during cns development.
13599	binds to 5s ribosomal rna (by similarity).
13600	
13601	
13602	
13603	
13604	high-affinity self-ligand important in bidirectional t- cell to b-cell stimulation. slam-induced signal-transduction events in t-lymphocytes are different from those in b-cells. two modes of slam signaling are likely to exist: one in which the inhibitor sh2d1a acts as a negative regulator and another in which protein-tyrosine phosphatase 2c (ptpn11)-dependent signal transduction operates.
13605	high-affinity self-ligand important in bidirectional t- cell to b-cell stimulation. slam-induced signal-transduction events in t-lymphocytes are different from those in b-cells. two modes of slam signaling are likely to exist: one in which the inhibitor sh2d1a acts as a negative regulator and another in which protein-tyrosine phosphatase 2c (ptpn11)-dependent signal transduction operates.
13606	removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. prefers acyl chain lengths of 14 to 18 carbons.
13607	
13608	cross-linked envelope protein of keratinocytes. it is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. all that results in the formation of an insoluble envelope beneath the plasma membrane.
13609	ligand for the t-cell-specific cell surface receptor icos. acts as a costimulatory signal for t-cell proliferation and cytokine secretion; induces also b-cell proliferation and differentiation into plasma cells. could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory t-cell function (by similarity).
13610	
13611	could be involved in cell-cell interactions.
13612	acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. it is thought to play a key role in cardiovascular homeostasis. helps restore the body@#$%&s salt and water balance. improves heart function.
13613	
13614	
13615	
13616	
13617	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
13618	
13619	
13620	part of a post-splicing multiprotein complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity (by similarity).
13621	type xii collagen interacts with type i collagen- containing fibrils, the col1 domain could be associated with the surface of the fibrils, and the col2 and nc3 domains may be localized in the perifibrillar matrix (by similarity).
13622	binds gtp, gdp and gmp.
13623	transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. binds dna on the 5@#$%&-ccac[ga]-3@#$%&half of the er stress response element (erse) (5@#$%&-ccaat-n(9)-ccac[ga]-3@#$%&) and of erse ii (5@#$%&-attgg-n-ccacg-3@#$%&). binding to erse requires binding of nf-y to erse. could also be involved in activation of transcription by the serum response factor.
13624	involved in tethering the chromosomes to the spindle pole and in chromosome movement. binds to the tail domain of the kif3a/kif3b heterodimer to form a heterotrimeric kif3 complex and may regulate the membrane binding of this complex (by similarity).
13625	interferes with cbl-mediated down-regulation and degradation of receptor-type tyrosine kinases. promotes accumulation of activated target receptors, such as t-cell receptors, egfr and pdgfrb, on the cell surface.
13626	
13627	
13628	an integral component of the pericentriolar material (pcm).
13629	probable glycosyltransferase (by similarity).
13630	involved in mediating interferon-gamma-induced cell death.
13631	
13632	
13633	
13634	
13635	endogenous activator of intestinal guanylate cyclase. it stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. may be a potent physiological regulator of intestinal fluid and electrolyte transport. may be an autocrine/paracrine regulator of intestinal salt and water transport.
13636	
13637	
13638	enhances transcription activation by yy1.
13639	involved in mediating interferon-gamma-induced cell death.
13640	plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-rna interactions required for accurate 3@#$%& splice site selection. recruits u2 snrnp to the branch point. directly mediates interactions between u2af2 and proteins bound to the enhancers and thus may function as a bridge between u2af2 and the enhancer complex to recruit it to the adjacent intron.
13641	
13642	
13643	may play a role in the regulation of pre-mrna splicing.
13644	spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. it associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
13645	not known.
13646	tafs are components of the transcription factor iid (tfiid) complex, pcaf histone acetylase complex and tbp-free tafii complex (tftc). tafs components-tiifd are essential for mediating regulation of rna polymerase transcription.
13647	ras proteins bind gdp/gtp and possess intrinsic gtpase activity.
13648	the association of the dr1/drap1 heterodimer with tbp results in a functional repression of both activated and basal transcription of class ii genes. this interaction precludes the formation of a transcription-competent complex by inhibiting the association of tfiia and/or tfiib with tbp. can bind to dna on its own.
13649	catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. in intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (by similarity).
13650	plays a major role in tight junction-specific obliteration of the intercellular space (by similarity).
13651	
13652	transcriptional activator. binds to fat body-specific enhancers of alcohol dehydrogenase (adh) and yolk protein genes. bbf-2 may play a role in fat body gene expression. it binds the consensus sequence 5@#$%&-t[ac]nacgtan[tg]c-3@#$%&.
13653	
13654	p53-regulated inhibitor of g2/m progression.
13655	
13656	catalyzes the formation of fatty acid-cholesterol esters. plays a role in lipoprotein assembly and dietary cholesterol absorption. in addition to its acyltransferase activity, it may act as a ligase.
13657	peptides at the n-terminal of hc-ii have chemotactic activity for both monocytes and neutrophils.
13658	implicated in the genesis of hemopoietic malignancies. it may play an important role in hemopoietic differentiation. serves as a positive regulator of erythroid differentiation. binds to the lim domain containing protein rhombotin-2.
13659	reversible hydration of carbon dioxide. may stimulate the sodium/bicarbonate transporter activity of slc4a4 (by similarity).
13660	receptor for the fc region of complexed immunoglobulins gamma. low affinity receptor.
13661	plays an important role in spindle pole orientation. interacts and contributes to the functional activity of g(i) alpha proteins. acts to stabilize the apical complex during neuroblast divisions.
13662	
13663	
13664	
13665	involved in molybdenum cofactor biosynthesis.
13666	
13667	guanine-nucleotide-releasing protein that acts on members of the sce4/ypt1/rab subfamily. stimulates gdp release from both ypt1 and rab3a, but is less active on these proteins than on the sec4 protein. might play a general role in vesicular transport.
13668	
13669	
13670	microtubule-based anterograde translocator for membranous organelles. plus end-directed microtubule sliding activity in vitro.
13671	
13672	may play a role in the initial growth and guidance of axons. may be involved in cell adhesion.
13673	
13674	terminal component of the liver microsomal stearyl-coa desaturase system, that utilizes o(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-coa substrates including palmitoyl-coa and stearoyl-coa.
13675	
13676	
13677	produces atp from adp in the presence of a proton gradient across the membrane. the gamma chain is believed to be important in regulating atpase activity and the flow of protons through the cf(0) complex.
13678	
13679	
13680	may play a role in the cellular processing of insulin. may be involved in intercellular peptide signaling.
13681	
13682	
13683	does not act as an allosteric activator of the cholera toxin catalytic subunit.
13684	
13685	involved in redox regulation of the cell. protects radical-sensitive enzymes from oxidative damage by a radical- generating system. acts synergistically with map3k13 to regulate the activation of nf-kappa-b in the cytosol.
13686	may play a role in targeting hzw10 to the kinetochore at prometaphase. part of the mis12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis.
13687	transcriptional activator (by similarity). binds a gc box motif. could play a role in b-cell growth and development.
13688	may play a role in tumor suppression.
13689	
13690	
13691	
13692	
13693	
13694	corepressor targeting diverse transcription regulators (by similarity).
13695	responsible for synthesis of pseudouridine from uracil- 55 in the psi gc loop of transfer rnas.
13696	
13697	
13698	
13699	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
13700	
13701	
13702	the substrate transported is not yet known. induces mitochondrial depolarization.
13703	not known, could be a tyrosine-phosphatase.
13704	part of a post-splicing multiprotein complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity (by similarity).
13705	
13706	promotes the exchange of ras-bound gdp by gtp. this protein positively controls the level of cellular camp at start, the stage at which the yeast cell division cycle is triggered.
13707	
13708	subunit of the splicing factor sf3b required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex. belongs also to the minor u12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mrna intron.
13709	protein transport. probably involved in vesicular traffic (by similarity).
13710	ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. can affect ras signaling at different levels. first, by competing with raf1 protein for binding to activated ras. second, by enhancing signaling from abl1 and abl2, which regulate cytoskeletal remodeling. third, by activating rab5a, possibly by functioning as a guanine nucleotide exchange factor (gef) for rab5a, by exchanging bound gdp for free gtp, and facilitating ras-activated receptor endocytosis.
13711	
13712	
13713	
13714	converts prothrombin to thrombin.
13715	thiol protease that cleaves il-1 beta between an asp and an ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
13716	
13717	catalyzes the transfer of mannose from dol-p-man to lipid-linked oligosaccharides.
13718	essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. required for the assembly of the dynein-dynactin complex onto kinetochores. its association with a snare-like complex suggests a role in membrane traffic between the endoplasmic reticulum and the golgi.
13719	likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the rxxx[kr]r consensus motif.
13720	possibly acts as a transcriptional regulatory factor.
13721	
13722	may be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus.
13723	component of the asymmetric unit membrane (aum); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. may play an important role in regulating the assembly of the aum (by similarity).
13724	component of the asymmetric unit membrane (aum); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. may play an important role in regulating the assembly of the aum (by similarity).
13725	
13726	
13727	
13728	serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
13729	mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. may also be required for the transfer of beta-barrel precursors from the tom complex to the sorting and assembly machinery (sam complex) of the outer membrane. acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
13730	vitamin b12-binding protein. transports cobalamin into cells.
13731	
13732	
13733	
13734	
13735	could be involved in the hypothalamic regulation of body weight.
13736	
13737	
13738	involved in the maintenance of cell wall integrity.
13739	
13740	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. plays a critical role in retinal angiogenesis.
13741	
13742	isoform ankyrin-ipla2-1 and isoform ankyrin-ipla2-2, which lack the catalytic domain, are probably involved in the negative regulation of ipla2 activity.
13743	associates with the ef-tu.gdp complex and induces the exchange of gdp to gtp. it remains bound to the aminoacyl-trna.ef- tu.gtp complex up to the gtp hydrolysis stage on the ribosome (by similarity).
13744	
13745	
13746	
13747	acts as a low affinity receptor for nicotinic acid and mediate its anti-lipolytic effect through a g(i)-protein-mediated inhibition of adenylyl cyclase. this pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
13748	involved in the regulation of structural processes in differentiating and mature neuronal cells (by similarity).
13749	receptor for adrenomedullin. the activity of this receptor is mediated by g proteins which activate adenylate cyclase (by similarity).
13750	binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
13751	
13752	
13753	
13754	
13755	
13756	
13757	may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.
13758	
13759	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
13760	binds to p-, e- and l-selectins. the calcium-dependent high affinity interaction with p-selectin mediates the tethering and rolling of neutrophils and t-lymphocytes on endothelial cells.
13761	
13762	this potassium channel is controlled by g proteins. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. can be blocked by external barium (by similarity).
13763	
13764	
13765	
13766	the s.cerevisiae ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-amp.
13767	
13768	
13769	cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers.
13770	
13771	
13772	
13773	
13774	
13775	
13776	
13777	
13778	catalyzes the initial reaction in o-linked oligosaccharide biosynthesis, the transfer of an n-acetyl-d- galactosamine residue to a serine or threonine residue on the protein receptor. has a broad spectrum of substrates for peptides such as ea2, muc5ac, muc1a, muc1b and muc7.
13779	
13780	
13781	copper chaperone for cytochrome c oxidase (cox). binds two copper ions and deliver them to the cu(a) site of cox (by similarity).
13782	functions in segment determination through interaction with genes of bithorax (bx-c) and antennapedia (ant-c) complexes. it can behave as an activator of bx-c. involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. shown to bind zinc (in vitro).
13783	activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. particularly involved in glucose-dependent regulation of insulin gene transcription. binds preferentially the dna motif 5@#$%&-[ct]taat[tg]-3@#$%&. during development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. at adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
13784	
13785	
13786	
13787	type iv collagen is the major structural component of glomerular basement membranes (gbm), forming a @#$%&chicken-wire@#$%& meshwork together with laminins, proteoglycans and entactin/nidogen.
13788	
13789	
13790	
13791	
13792	suppresses neurite outgrowth (by similarity).
13793	kinase that may play a role in mitotic regulation.
13794	
13795	
13796	
13797	
13798	may function as a housekeeping dna-binding protein that regulates the expression of specific genes. has been shown to bind to the promoters of adenovirus major late protein and cyclin d1 and activate transcription. also has potent growth arrest activity, probably through inhibition of cell cycle progression. required for early embryonic development during gastrulation.
13799	controls reversibly actin polymerization and depolymerization in a ph-sensitive manner. it has the ability to bind g- and f-actin in a 1:1 ratio of cofilin to actin. it is the major component of intranuclear and cytoplasmic actin rods (by similarity).
13800	implicated in immunoproteasome assembly and required for efficient antigen processing. the pa28 activator complex enhances the generation of class i binding peptides by altering the cleavage pattern of the proteasome.
13801	transcription regulatory factor that mediates signaling by type i ifns (ifn-alpha and ifn-beta). following type i ifn binding to cell surface receptors, jak kinases (tyk2 and jak1) are activated, leading to tyrosine phosphorylation of stat1 and stat2. the phosphorylated stats dimerize, associate with isgf3g/irf-9 to form a complex termed isgf3 transcription factor, that enters the nucleus. isgf3 binds to the ifn stimulated response element (isre) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
13802	
13803	
13804	
13805	
13806	component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. also component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport. responsible for the localizing and stabilizing vault rna (vrna) association in the vault ribonucleoprotein particle (by similarity).
13807	spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. it associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
13808	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression.
13809	binds to the il-1 type i receptor following il-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mrna stabilization. isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for il-1 signaling. once phosphorylated, irak1 recruits the adapter protein peli1.
13810	
13811	catalyzes an essential step in the conversion of oligo- mannose to complex n-glycans.
13812	tfiia is a component of the transcription machinery of rna polymerase ii and plays an important role in transcriptional activation. interacts with tbp (the tata-binding protein).
13813	
13814	catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. responsible for cross- linking epidermal proteins during formation of the stratum corneum.
13815	
13816	
13817	
13818	fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. fibrillin-1- containing microfibrils provide long-term force bearing structural support.
13819	
13820	
13821	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. has angiogenic inhibitor activity (by similarity). active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture (by similarity).
13822	
13823	
13824	essential for the control of the cell cycle at the g2/m (mitosis) transition.
13825	
13826	type i collagen is a member of group i collagen (fibrillar forming collagen).
13827	
13828	antagonist of signaling by tgf-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively bmp (bone morphogenetic proteins) signaling by competing with the co-smad smad4 for receptor-activated smad1. smad6 is an inhibitory smad (i-smad) or antagonistic smad.
13829	involved in cytoplasm to vacuole transport (cvt) vesicles and autophagosomes formation. with atg4, may mediate the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton. participates also in membrane fusion events that take place in the early secretory pathway.
13830	
13831	
13832	
13833	muscle contraction.
13834	
13835	
13836	
13837	
13838	transcriptional repressor of genes that require a bhlh protein for their transcription. may act as a negative regulator of myogenesis by inhibiting the functions of myod1 and ash1 (by similarity).
13839	
13840	
13841	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
13842	
13843	
13844	unknown, though mvp is required for normal vault structure. vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport.
13845	
13846	
13847	
13848	implicated as a tumor suppressor. may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. interaction between hamartin and tuberin may facilitate vesicular docking. specifically stimulates the intrinsic gtpase activity of the ras-related protein rap1a and rab5. suggesting a possible mechanism for its role in regulating cellular growth. mutations in tuberin leads to constitutive activation of rap1a in tumors.
13849	
13850	
13851	
13852	could promote homologous recombination at sites of dna damage. rrp1 has apurinic endonuclease and double-stranded dna 3@#$%& exonuclease, activities and carries out single-stranded dna renaturation in a mg(2+)-dependent manner.
13853	
13854	thought to stabilize the calcium channel in an inactivated (closed) state.
13855	
13856	phosphorylates and activates not only pkb/akt, but also pka, pkc-zeta, p70s6k and p90s6k/rsk. may play a general role in signaling processes and in development (by similarity). isoform 3 is catalytically inactive.
13857	
13858	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
13859	may be involved in transcriptional regulation.
13860	may be involved in transcriptional regulation.
13861	
13862	docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. implicated in induction of cell migration. overexpression confers antiestrogen resistance on breast cancer cells.
13863	
13864	integrin alpha-6/beta-4 is a receptor for laminin. it plays a critical structural role in the hemidesmosome of epithelial cells.
13865	
13866	
13867	
13868	
13869	
13870	
13871	may control phosphatidylinositol concentration in transport vesicles from the subrhabdomeric cisternae (src) to the rhabdomere. may function as a calcium transporter.
13872	
13873	involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of dna-nucleosome topology).
13874	
13875	
13876	transfers a sulfuryl group to an n-unsubstituted glucosamine linked to a 2-o-sulfo iduronic acid unit on heparan sulfate. catalyzes the o-sulfation of glucosamine in idoua2s-glcns and also in idoua2s-glcnh2. the substrate-specific o-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to herpes simplex virus-1 (hsv-1) and permits its entry. unlike 3-ost-1, does not convert nonanticoagulant heparan sulfate to anticoagulant heparan sulfate.
13877	
13878	
13879	
13880	
13881	functions as a histone acetyltransferase (hat) to promote transcriptional activation. acetylation of histones gives a specific tag for epigenetic transcription activation. has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles.
13882	in response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. binds to ccr3.
13883	component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the f-actin cytoskeleton and the extracellular matrix.
13884	binds double-stranded dna. binds dinucleosomes, probably at the linker region between neighboring nucleosomes. plays a role in chromatin remodeling (by similarity). required for the function of some acidic activation domains, which activate transcription from a distant site.
13885	
13886	
13887	
13888	
13889	may play a role in germ line formation.
13890	
13891	
13892	
13893	may control phosphatidylinositol concentration in transport vesicles from the subrhabdomeric cisternae (src) to the rhabdomere. may function as a calcium transporter.
13894	
13895	
13896	
13897	
13898	atp citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-coa in many tissues. has a central role in de novo lipid synthesis. in nervous tissue it may be involved in the biosynthesis of acetylcholine.
13899	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
13900	
13901	
13902	
13903	
13904	
13905	the smn complex plays an essential role in spliceosomal snrnp assembly in the cytoplasm and is required for pre-mrna splicing in the nucleus.
13906	the smn complex plays an essential role in spliceosomal snrnp assembly in the cytoplasm and is required for pre-mrna splicing in the nucleus.
13907	
13908	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds to g(t)-alpha. involved in phototransduction; key element in the recovery phase of visual transduction (by similarity).
13909	probably involved in the organization of the actin cytoskeleton. may act downstream of cdc42 to induce actin filament assembly leading to cell shape changes. induces pseudopodia formation, when overexpressed in fibroblasts.
13910	
13911	
13912	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
13913	transcriptional activator. activates the transcription of a number of liver genes such as hnf3b.
13914	catalyzes the removal of elemental sulfur from cysteine to produce alanine. it supplies the inorganic sulfur for iron- sulfur (fe-s) clusters.
13915	may be involved in transcriptional regulation.
13916	
13917	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
13918	
13919	involved in the release of sentrins (potential).
13920	
13921	essential ppiase that regulates mitosis presumably by interacting with nima and attenuating its mitosis-promoting activity. displays a preference for an acidic residue n-terminal to the isomerized proline bond. catalyzing pser/thr-pro cis/trans isomerizations.
13922	directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.
13923	the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-coa and co(2). it contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (e1), lipoamide acyltransferase (e2) and lipoamide dehydrogenase (e3).
13924	is able to inhibit all four classes of proteinases by a unique @#$%&trapping@#$%& mechanism. this protein has a peptide stretch, called the @#$%&bait region@#$%& which contains specific cleavage sites for different proteinases. when a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. the entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
13925	
13926	cytokine that binds to tnfrsf9. induces the proliferation of activated peripheral blood t-cells. may have a role in activation-induced cell death (aicd). may play a role in cognate interactions between t-cells and b-cells/macrophages.
13927	part of the snapc complex required for the transcription of both rna polymerase ii and iii small-nuclear rna genes. binds to the proximal sequence element (pse), a non-tata-box basal promoter element common to these 2 types of genes. recruits tbp and brf2 to the u6 snrna tata box.
13928	
13929	may be involved in transcriptional regulation.
13930	molecular calcium binding chaperone promoting folding, oligomeric assembly and quality control in the er via the calreticulin/calnexin cycle. this lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the er. interacts with the dna-binding domain of nr3c1 and mediates its nuclear export.
13931	type i collagen is a member of group i collagen (fibrillar forming collagen).
13932	
13933	orphan receptor. binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5@#$%&-aggtca-3@#$%& and 4-nt spacing (dr-4).
13934	
13935	
13936	binds specifically to phosphatidylinositol-3-phosphate (ptdins3p), but not to other phosphoinositides.
13937	
13938	catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands.
13939	
13940	binds calmodulin in a calcium dependent manner. may function as scaffolding or signaling protein.
13941	
13942	
13943	may be involved in transcriptional regulation.
13944	troponin i is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin atpase activity.
13945	
13946	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins. necessary for activation of the cdc28 kinase.
13947	
13948	forms a voltage-independent potassium channel that is activated by intracellular calcium. activation is followed by membrane hyperpolarization which promotes calcium influx. the channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
13949	
13950	cytotoxin and helminthotoxin. also induces noncytolytic histamine release from human basophils. involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. the proform acts as a proteinase inhibitor, reducing the activity of pappa.
13951	the function of brain maps is essentially unknown. phosphorylated map1b may play a role in the cytoskeletal changes that accompany neurite extension. possibly map1b binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules.
13952	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
13953	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
13954	
13955	may play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. required for sperm motility and male fertility (by similarity).
13956	regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction.
13957	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
13958	binds specifically to peptidoglycan and is involved in innate immunity.
13959	transcriptional repressor.
13960	heterodimers between tcf3 and tissue-specific basic helix-loop-helix (bhlh) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early b-cell differentiation. dimers bind dna on e-box motifs: 5@#$%&- canntg-3@#$%&. binds to the kappa-e2 site in the kappa immunoglobulin gene enhancer.
13961	
13962	
13963	may be involved in transcriptional regulation.
13964	implicated in brca1-mediated tumor suppression. may, as part of the rna polymerase-2 holoenzyme, function in the cellular response to dna damage. in vitro, inhibits pre-mrna 3@#$%& cleavage.
13965	necessary for sperm flagellar function.
13966	thought to stabilize the calcium channel in an inactivated (closed) state (by similarity). modulates calcium current when coexpressed with cacna1g.
13967	
13968	
13969	mediates odorant detection (possibly) via modulation of intracellular camp concentration.
13970	mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient.
13971	involved in cell wall synthesis where it is required for glycosylation. involved in cell cycle progression through cell- size checkpoint.
13972	
13973	may have a functional role during normal fetal development.
13974	
13975	
13976	transcriptional activator. binds in vitro to the caccc motif of the beta-globin promoter and to the sp1 recognition sequence.
13977	
13978	receptor for interleukin-1 alpha (il-1a), beta (il-1b), and interleukin-1 receptor antagonist protein (il-1ra). binding to the agonist leads to the activation of nf-kappa-b. signaling involves formation of a ternary complex containing il1rap, tollip, myd88, and irak1 or irak2.
13979	this is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of na(+) and k(+) ions across the plasma membrane. the exact function of the beta-3 subunit is not known.
13980	component of a nucleolar small nuclear ribonucleoprotein particle (snornp) thought to participate in the processing and modification of pre-ribosomal rna.
13981	carries out a dual function: signal transduction and activation of transcription. involved in il12 signaling.
13982	single-stranded nucleic acid binding protein that binds preferentially to oligo dc.
13983	
13984	
13985	
13986	plays an important role in the organization of the cytoskeleton. binds to and sequesters actin monomers (g actin) and therefore inhibits actin polymerization (by similarity).
13987	promotes guanine-nucleotide exchange on arf1. promotes the activation of arf through replacement of gdp with gtp.
13988	
13989	
13990	may be involved in embryonic development.
13991	
13992	acts both in vulval induction and sex myoblast migration. presumably interacts with the kinase receptor let-23 and with a target that modifies the ras-like protein let-60.
13993	catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
13994	
13995	may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
13996	orphan receptor.
13997	
13998	
13999	
14000	
14001	
14002	
14003	
14004	acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin g. may prevent elastase-mediated damage to oral and possibly other mucosal tissues (by similarity).
14005	
14006	transfers mannose from gdp-mannose to dolichol monophosphate to form dolichol phosphate mannose (dol-p-man) which is the mannosyl donor in pathways leading to n-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and o- mannosylation of proteins.
14007	
14008	induces cartilage and bone formation. may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. plays a role in calcium regulation and bone homeostasis.
14009	
14010	binds to tyrosine-protein kinase receptor tie2 and activates it.
14011	
14012	
14013	
14014	acts as a factor that allows the dna to undergo a single round of replication per cell cycle. required for dna replication and cell proliferation.
14015	
14016	inhibits papain and cathepsin l but with affinities lower than other cystatins. may play a role in immune regulation through inhibition of a unique target in the hematopoietic system.
14017	
14018	
14019	promotes cell adhesion (by similarity).
14020	
14021	
14022	probable transcriptional regulator protein that binds to dna as dimer and tetramer, but not as a monomer. binds to g- doublets in an a/t-rich environment; the preferred motif is a tandem repeat of 5@#$%&-attggtta-3@#$%& combined with a 5@#$%&-ttatta-3@#$%& box. may be involved in immune regulation.
14023	stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.
14024	may play a role in cell motility and cell adhesion.
14025	
14026	dephosphorylates and concomitantly deactivates cam- kinase ii activated upon autophosphorylation, and cam-kinases iv and i activated upon phosphorylation by cam-kinase kinase. promotes apoptosis.
14027	core component of the hswi/snf complex. this atp- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. the hswi/snf complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. this change in supercoiling would be due to the convertion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. stimulates in vitro the remodeling activity of smarca4/brg1. involved in activation of csf1 promoter. plays a key role in cell-cycle control and causes cell cycle arrest in g0/g1.
14028	muscle contraction.
14029	
14030	
14031	
14032	may play a role in cell proliferation, differentiation and death.
14033	
14034	
14035	has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. could be involved in the resistance to anti-tumor agents. possesses a dithiol-reducing activity.
14036	probably involved in translation.
14037	receptor for somatostatins-14 and -28. this receptor is coupled via pertussis toxin sensitive g proteins to inhibition of adenylyl cyclase.
14038	may be a cytoskeletal regulator.
14039	the l3 protein is a component of the large subunit of cytoplasmic ribosomes.
14040	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
14041	
14042	
14043	
14044	
14045	
14046	major component of the descemet@#$%&s membrane (basement membrane) of corneal endothelial cells.
14047	may be involved in transcriptional regulation.
14048	involved in the repair of mismatches in dna.
14049	
14050	receptor for ccl2, ccl8, ccl13, ccl19, ccl21 and ccl25.
14051	may play a role in the antiviral response of interferon (ifn) by amplifying and enhancing the ifn response through increased expression of select subset of potent antiviral genes. may contribute to cytokine-regulated cell proliferation and differentiation.
14052	e3 ubiquitin ligase protein that mediates ubiquitination and subsequent proteasomal degradation of target proteins. e3 ubiquitin ligases accept ubiquitin from an e2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. mediates e3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential ring domain subunit of larger e3 complexes. triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (pou2af1, pml, ncor1), a cell surface receptor (dcc), an antiapoptotic protein (bag1), and a protein involved in synaptic vesicle function in neurons (syp). it is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. has some overlapping function with siah1. triggers the ubiquitin-mediated degradation of traf2, whereas siah1 can not.
14053	
14054	may play a role in binding dynein to membranous organelles or chromosomes. may associate with the heavy chains in the dynein head where they might regulate enzyme activity (by similarity).
14055	
14056	receptor for extracellular adenine nucleotides such as atp and adp. in pancreatic islets, may mediate some of the effects of extracellular atp on insulin secretion.
14057	
14058	
14059	
14060	
14061	
14062	
14063	involved in transcriptional activation and repression of select genes by chromatin remodelling (alteration of dna- nucleosome topology). required for maximal atpase activity of smarca4/brg1 and for association of the smarca4/brg1 containing remodelling complex baf with chromatin/nuclear matrix. component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. nua4 may also play a direct role in dna repair when recruited to sites of dna damage.
14064	
14065	may act as a negative regulator of ras-mediated mitogenic activity.
14066	receptor for a c-c type chemokine. binds to mip-1-alpha, mip-1-beta and rantes and subsequently transduces a signal by increasing the intracellular calcium ions level.
14067	
14068	
14069	
14070	receptor for ptpns1. may play a role in membrane transport and/or signal transduction. may prevent premature elimination of red blood cells. may be involved in membrane permeability changes induced following virus infection. may play a role in memory formation. has a role in cell adhesion.
14071	
14072	transferrins are iron binding transport proteins which can bind two fe(3+) ions in association with the binding of an anion, usually bicarbonate. it is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. serum transferrin may also have a further role in stimulating cell proliferation.
14073	
14074	
14075	
14076	
14077	
14078	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
14079	regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. serves as a target for the yopt cysteine peptidase from yersinia pestis, vector of the plague, and yersinia pseudotuberculosis, which causes gastrointestinal disorders.
14080	regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. serves as a target for the yopt cysteine peptidase from yersinia pestis, vector of the plague, and yersinia pseudotuberculosis, which causes gastrointestinal disorders.
14081	tetranectin binds to plasminogen and to isolated kringle 4. may be involved in the packaging of molecules destined for exocytosis.
14082	
14083	
14084	
14085	stimulates muscle contractions of specific regions of the gastrointestinal tract. in humans, nmu stimulates contractions of the ileum and urinary bladder.
14086	
14087	could function as a cell-adhesion protein.
14088	
14089	receptor for netrin required for axon guidance. mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. axon repulsion in growth cones may be caused by its association with dcc that may trigger signaling for repulsion. also involved in corticospinal tract axon guidances independently of dcc. it also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (by similarity).
14090	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins that stimulate adenylate cyclase. it has a high affinity for tricyclic psychotropic drugs.
14091	
14092	
14093	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.
14094	
14095	receptor for neuropeptide y and peptide yy. the rank order of affinity of this receptor for pancreatic polypeptides is npy > [pro-34] pyy, pyy and [leu-31, pro-34] npy > npy (2-36) > [ile-31, gln-34] pp and pyy (3-36) > pp > npy free acid.
14096	this protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
14097	the s.cerevisiae ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-amp.
14098	
14099	
14100	pre-mrna processing factor involved in disassembly of spliceosomes after the release of mature mrna (by similarity).
14101	
14102	
14103	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
14104	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. the n-terminus interacts with and regulates xpd whereas an intact c- terminus is required for a successful escape of rnap ii form the promoter.
14105	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
14106	has a glutathione-disulfide oxidoreductase activity in the presence of nadph and glutathione reductase. reduces low molecular weight disulfides and proteins.
14107	involved in transcription.
14108	
14109	part of the ap-3 complex, an adapter-related complex which is not clathrin-associated. the complex is associated with the golgi region as well as more peripheral structures. it facilitates the budding of vesicles from the golgi membrane and may be directly involved in trafficking to lysosomes.
14110	transcriptional activator. binds to the dna sequence 5@#$%&- acaat-3@#$%& and shows a preference for guanine residues surrounding this core motif.
14111	
14112	involved in cell motility. when hyaluronan binds to hmmr, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. may also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (erk) activity.
14113	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
14114	macro-h2a occupies the place of conventional h2a in a subset of nucleosomes where it represses transcription. involved in stable x chromosome inactivation. inhibits the binding of transcription factors and interferes with the activity of remodelling swi/snf complexes. inhibits histone acetylation by ep300 and recruits class i hdacs, which induces an hypoacetylated state of chromatin. in addition, isoform 1, but not isoform 2, binds adp-ribose and o-acetyl-adp-ribose, and may be involved in adp-ribose-mediated chromatin modulation.
14115	may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. in association with the sfpq-nono heteromer may play a role in nuclear retention of defective rnas.
14116	adds the first dol-p-man derived mannose in an alpha 1,3 linkage to man5glcnac2-pp-dol.
14117	
14118	
14119	plays a critical role in mhc class ii antigen processing by stabilizing peptide-free class ii alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class ii takes place.
14120	involved in amino acid efflux from the vacuole to the cytoplasm. capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine.
14121	involved in vesicular protein trafficking.
14122	the transhydrogenation between nadh and nadp is coupled to respiration and atp hydrolysis and functions as a proton pump across the membrane.
14123	integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen c-propeptides, fibronectin and e-cadherin. it recognizes the proline-hydroxylated sequence g-f-p-g-e-r in collagen. it is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
14124	
14125	sequence-selective dna-binding protein. could play an important role in gene regulation.
14126	
14127	
14128	functions as a dosage-dependent inducer in mitotic control. it is a tyrosine protein phosphatase required for progression of the cell cycle. it directly dephosphorylates cdc2 and activate its kinase activity.
14129	this is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity.
14130	
14131	
14132	
14133	
14134	
14135	
14136	
14137	converts lysophosphatidic acid (lpa) into phosphatidic acid by incorporating acyl moiety at the 2 position (by similarity).
14138	
14139	probable e3 ubiquitin-protein ligase required to ubiquitinate some nuclear proteins, and promote their subsequent degradation.
14140	probable c to u editing enzyme whose physiological substrate is not yet known. does not display detectable apob mrna editing. has a low intrinsic cytidine deaminase activity.
14141	growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. binds to the vegfr1/flt-1 and vegfr2/kdr receptors, heparan sulfate and heparin. neuropilin-1 binds isoforms vegf-165 and vegf-145.
14142	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
14143	
14144	histone h3, along with histone h4, plays a central role in nucleosome formation.
14145	histones h1 are necessary for the condensation of nucleosome chains into higher order structures.
14146	
14147	
14148	
14149	
14150	
14151	involved in the presentation of foreign antigens to the immune system.
14152	in cooperation with other chaperones, hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. these chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. they bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (by similarity).
14153	
14154	
14155	may be involved in retrograde transport of early and late endosomes to the late golgi.
14156	receptor for glutamate. the activity of this receptor is mediated by a g-protein that inhibits adenylate cyclase activity.
14157	receptor for neuromedin-b.
14158	
14159	
14160	may play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
14161	
14162	may cooperate with cd180 and tlr4 to mediate the innate immune response to bacterial lipopolysaccharide (lps) and cytokine production. important for efficient cd180 cell surface expression (by similarity).
14163	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
14164	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
14165	orphan receptor.
14166	
14167	
14168	may function as suppressor of malignant melanoma. it may exert its effects through interactions with the cytoskeleton.
14169	
14170	
14171	g protein-coupled receptor that probably associates with the patched protein (ptch) to transduce the hedgehog@#$%&s proteins signal. binding of sonic hedgehog (shh) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (smo).
14172	
14173	
14174	plays a major role in regulating hemoglobin oxygen affinity as a consequence of controlling 2,3-bpg concentration. can also catalyze the reaction of ec 5.4.2.1 (mutase) and ec 3.1.3.13 (phosphatase), but with a reduced activity.
14175	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
14176	might possibly play a role in rna metabolism.
14177	
14178	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
14179	
14180	
14181	
14182	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
14183	catalyzes the n-methylation of tryptamine and structurally related compounds (potential).
14184	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to sites in the 5@#$%&-flanking sequence of its coding region with various affinities. the consensus sequences of the high and low affinity binding sites are 5@#$%&-taatga[cg]-3@#$%& and 5@#$%&-ctaatttt- 3@#$%&.
14185	may act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking (by similarity).
14186	
14187	probable core protein of the multisynthetase complex that serves as a template for the assembly of the supramolecular structure. mediates ubiquitination of fubp1 and its degradation by the proteasome.
14188	required for dna recombination, repair and replication. the activity of rp-a is mediated by single-stranded dna binding and protein interactions.
14189	binds the stem-loop structure of replication-dependent histone pre-mrnas and contributes to efficient 3@#$%& end processing by stabilizing the complex between histone pre-mrna and u7 small nuclear ribonucleoprotein (snrnp). could play an important role in targeting mature histone mrna from the nucleus to the cytoplasm and to the translation machinery. stabilizes mature histone mrna and could be involved in cell-cycle regulation of histone gene expression.
14190	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
14191	may play a functional role in the cell filament networks.
14192	il-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of b-cells into ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
14193	essential for recycling gmp and indirectly, cgmp.
14194	binds to gt and gc boxes promoters elements. probable transcriptional activator.
14195	probable transcription factor, which seems to be involved in the negative regulation of cellular determination and in the differentiation of several lineages including myogenesis, osteogenesis, and neurogenesis. inhibits myogenesis by sequestrating e proteins, inhibiting trans-activation by mef2, and inhibiting dna-binding by myod1 through physical interaction. this interaction probably involves the basic domains of both proteins (by similarity). also represses expression of proinflammatory cytokines such as tnfa and il1b.
14196	probable transcription factor, which seems to be involved in the negative regulation of cellular determination and in the differentiation of several lineages including myogenesis, osteogenesis, and neurogenesis. inhibits myogenesis by sequestrating e proteins, inhibiting trans-activation by mef2, and inhibiting dna-binding by myod1 through physical interaction. this interaction probably involves the basic domains of both proteins (by similarity). also represses expression of proinflammatory cytokines such as tnfa and il1b.
14197	it is able to complement the radiosensitivity defect of an ataxia telangiectasia (at) fibroblast cell line.
14198	it is able to complement the radiosensitivity defect of an ataxia telangiectasia (at) fibroblast cell line.
14199	
14200	
14201	reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin ix alpha, to bilirubin with the concomitant oxidation of a nadh or nadph cofactor.
14202	calcium selective cation channel probably involved in ca(2+) uptake in various tissues, including ca(2+) reabsorption in intestine. the channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. inactivation includes both, a rapid ca(2+)-dependent and a slower ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. in vitro, is slowly inhibited by mg(2+) in a voltage-independent manner. heteromeric assembly with trpv5 seems to modify channel properties. trpv5-trpv6 heteromultimeric concatemers exhibit voltage-dependent gating (by similarity).
14203	
14204	
14205	
14206	may be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides (by similarity).
14207	stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. may bind polyunsaturated fatty acids.
14208	stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. may bind polyunsaturated fatty acids.
14209	
14210	may bind rna.
14211	
14212	
14213	involved in matrix assembly (by similarity).
14214	
14215	could have a role in the differentiation of photoreceptor cells.
14216	
14217	not known, could be a tyrosine-phosphatase.
14218	
14219	probable protease subunit of the cop9 signalosome complex (csn), a complex involved in various cellular and developmental processes. the csn complex is an essential regulator of the ubiquitin (ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the scf-type e3 ligase complexes, leading to decrease the ubl ligase activity of scf-type complexes such as scf, csa or ddb2. the complex is also involved in phosphorylation of p53/tp53, c-jun/jun, ikappabalpha/nfkbia, itpk1 and icsbp, possibly via its association with ck2 and pkd kinases. csn-dependent phosphorylation of tp53 and jun promotes and protects degradation by the ubl system, respectively. in the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. it however has no metalloprotease activity by itself and requires the other subunits of the csn complex. interacts direclty with a large number of proteins that are regulated by the csn complex, confirming a key role in the complex.
14220	
14221	
14222	has chemotactic activity for neutrophils. may play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. in vitro, the processed forms gro- alpha(4-73), gro-alpha(5-73) and gro-alpha(6-73) show a 30-fold higher chemotactic activity.
14223	may be involved in protein transport from golgi to cell surface. the zdhhc9-golga7 complex is a palmitoyltransferase specific for hras and nras.
14224	auxiliary enzyme of beta-oxidation. it participates in the metabolism of unsaturated fatty enoyl-coa esters having double bonds in both even- and odd-numbered positions. catalyzes the nadp-dependent reduction of 2,4-dienoyl-coa to yield trans-3- enoyl-coa.
14225	
14226	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
14227	
14228	
14229	acts as decoy receptor for rankl and thereby neutralizes its function in osteoclastogenesis. inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. bone homeostasis seems to depend on the local rankl/opg ratio. may also play a role in preventing arterial calcification. may act as decoy receptor for trail and protect against apoptosis. trail binding blocks the inhibition of osteoclastogenesis.
14230	
14231	dna-dependent atpase. may modulate chromosome segregation.
14232	
14233	could be a global transcriptional regulator. modifies gene expression by affecting chromatin. may be involved in brain development and facial morphogenesis.
14234	interacts with htr2c and provokes its clustering at the cell surface (by similarity). member of the nmdar signaling complex that may play a role in control of ampar potentiation and synaptic plasticity in excitatory synapses.
14235	may play an important role in b-cell differentiation as well as neural development and spermatogenesis. involved in the regulation of the cd19 gene, a b-lymphoid-specific target gene.
14236	
14237	dna repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. may be implicated in interstrand dna cross-link repair and in the maintenance of normal chromosome stability. candidate tumor suppressor gene.
14238	receptor tyrosine kinase that is a key mediator of agrin@#$%&s action and is involved in neuromuscular junction (nmj) organization (by similarity).
14239	dna repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. may be implicated in interstrand dna cross-link repair and in the maintenance of normal chromosome stability.
14240	orphan nuclear receptor.
14241	
14242	
14243	binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
14244	
14245	
14246	
14247	has antiviral, antibacterial and anticancer activities.
14248	catalyzes the conversion of pgh2 to pgd2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. involved in a variety of cns functions, such as sedation, nrem sleep and pge2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. it is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
14249	
14250	involved in bile acid metabolism. in liver hepatocytes catalyzes the second step in the conjugation of c24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. the major components of bile are cholic acid and chenodeoxycholic acid. in a first step the bile acids are converted to an acyl-coa thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). may catalyze the conjugation of primary or secondary bile acids, or both. the conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. in turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). may also act as an acyl-coa thioesterase that regulates intracellular levels of free fatty acids. in vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-coas to the free fatty acid and coenzyme a (coash), and conjugates glycine to these acyl-coas.
14251	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&.
14252	
14253	derived from proteolytic degradation of complement c5, c5 anaphylatoxin is a mediator of local inflammatory process. it induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. c5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
14254	
14255	receptor for interleukin-11. the receptor systems for il6, lif, osm, cntf, il11 and ct1 can utilize il6st for initiating signal transmission. the il11/il11ra/il6st complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.
14256	
14257	required for protein transport from the er to the golgi complex.
14258	
14259	phosphorylates a large number of substrates in the cytoplasm and the nucleus.
14260	
14261	
14262	
14263	
14264	
14265	
14266	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. the produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
14267	
14268	component of the mediator complex, a complex that can either repress or activate transcription. mediator complexes are essential for basal and regulated expression of nearly all rna polymerase ii-dependent genes. they may act as a bridge, conveying regulatory information from enhancers and other control elements to the promoter. may be part of a complex containing nf2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.
14269	
14270	mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.
14271	
14272	non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via g-protein coupled receptor (gpcr) occupancy by ligands such as bombesin or lysophosphatidic acid, or via ldl receptor occupancy. plays a potential role in oncogenic transformations resulting in increased kinase activity.
14273	
14274	conversion of gdp-d-mannose to gdp-4-keto-6-d- deoxymannose.
14275	receptor for interleukin-12. this subunit is the signaling component coupling to the jak2/stat4 pathway. promotes the proliferation of t-cells as well as nk cells. induces the promotion of t-cells towards the th1 phenotype by strongly enhancing ifn-gamma production.
14276	
14277	responsible for cleaving the alpha-chains of c4b and c3b in the presence of the cofactors c4-binding protein and factor h respectively.
14278	
14279	
14280	
14281	essential component of the scf (skp1-cul1-f-box protein) e3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. in the scf complex, serves as a rigid scaffold that organizes the skp1-f-box protein and rbx1 subunits. may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
14282	plays a role in transcriptional coactivation.
14283	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
14284	
14285	
14286	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
14287	
14288	
14289	receptor for arginine vasopressin. the activity of this receptor is mediated by g proteins which activate a phosphatidyl- inositol-calcium second messenger system.
14290	
14291	catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. has little activity towards prostaglandins a1 and e1.
14292	
14293	
14294	provides cdp-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (ptdins), phosphatidylglycerol, and cardiolipin. overexpression may amplify cellular signaling responses from cytokines. may also play an important role in the signal transduction mechanism of retina and neural cells.
14295	may play a role in organizing the actin cytoskeleton of the brain cells.
14296	may overlap in function with tropomyosin and may be involved in organization of actin filaments. acts as a multicopy suppressor of rho3 mutation. rna-binding protein which may modulate mrna translation. involved in heme regulation of hap1, as a component of the high-molecular-weight complex (hmc).
14297	probable oxidoreductase that acts as a caspase- independent mitochondrial effector of apoptotic cell death. extramitochondrial aif induces nuclear chromatin condensation and large scale dna fragmentation (in vitro).
14298	involved in axon growth. plays an essential role in neurite extension of cerebellar granule cells (by similarity).
14299	may be involved in several stages of intracellular trafficking.
14300	
14301	may serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
14302	
14303	involved in intracellular signal transduction mediated by cytokines and growth factors. when associated with stam, it suppresses dna signaling upon stimulation by il-2 and gm-csf. could be a direct effector of pi3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. may concentrate ubiquitinated receptors within clathrin-coated regions. involved in down- regulation of receptor tyrosine kinase via multivesicular body (mvbs) when complexed with stam. this complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. may contribute to the efficient recruitment of smads to the activin receptor complex.
14304	probable zinc protease. may mediate cell-cell or cell- matrix interactions. isoform 2 displays alpha-secretase activity for app.
14305	
14306	binds opioids in the presence of acidic lipids; probably involved in cell contact.
14307	
14308	required for protein transport from the er to the golgi complex.
14309	
14310	implicated in the control of cell growth. component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals.
14311	catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.
14312	
14313	required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo. induces the formation of visceral mesoderm and the heart in early embryos. required later in embryogenesis for dorsal closure and patterning of the hindgut. also functions postembryonically as a long-range morphogen during imaginal disk development; is responsible for the progression of the morphogenetic furrow during eye development. patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. ensures the correct architecture of wing epithelial cells. has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. required for viability of larvae. essential for the maintenance and division of germline stem cells in the ovary. signals via the type i receptor tkv, the type ii receptor punt, and in some tissues via the type i receptor sax, in a signaling cascade that leads to activation and repression of target genes.
14314	
14315	stabilizer subunit of the dolichol-phosphate-mannose synthase complex.
14316	
14317	
14318	
14319	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
14320	
14321	
14322	
14323	influences outgrowth of olfactory axons and migration of lhrh neurons (by similarity).
14324	aminopeptidases catalyze the hydrolysis of amino acid residues from the n-terminus of peptide or protein substrates. able to cleave angiotensin iii to generate angiotensin iv, a bioactive peptide of the renin-angiotensin pathway. not able to cleave angiotensin i and angiotensin ii. may play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.
14325	
14326	
14327	
14328	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. binds selectively to g(z)-alpha and is inhibited by phosphorylation and palmitoylation of the g- protein.
14329	anticoagulant plasma protein; it is a cofactor to activated protein c in the degradation of coagulation factors va and viiia. it helps to prevent coagulation and stimulating fibrinolysis.
14330	
14331	acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type i immunity (by similarity).
14332	type i collagen is a member of group i collagen (fibrillar forming collagen).
14333	
14334	
14335	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
14336	
14337	probable atpase involved in the assembly or function of nuclear protein complexes. may also be involved in some aspects of microtubule dynamics (by similarity).
14338	
14339	
14340	activates cdc42, a member of the ras-like family of rho- and rac proteins, by exchanging bound gdp for free gtp. plays a role in regulating the actin cytoskeleton and cell shape.
14341	is part of lamellipodial complex that controls rac- dependent acting remodelling (by similarity).
14342	synthesizes cyclic adp-ribose, a second messenger that elicits calcium release from intracellular stores. may be involved in pre-b-cell growth.
14343	
14344	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes, such as ube2l3/ubcm4, and then transfers it to substrates.
14345	
14346	
14347	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
14348	
14349	
14350	receptor for endothelin-1. mediates its action by association with g proteins that activate a phosphatidylinositol- calcium second messenger system. the rank order of binding affinities for et-a is: et1 > et2 >> et3.
14351	sulfate transporter. may play a role in endochondral bone formation.
14352	udpgt is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
14353	
14354	substrate of the antigen receptor-coupled tyrosine kinase. plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. may also be involved in the regulation of gene expression.
14355	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
14356	plays a fundamental role in microtubule-organizing center structure and function.
14357	
14358	involved in the transduction of mitogenic signals from the cell membrane to the nucleus.
14359	not known, seems to be associated with pigmentation.
14360	may overlap in function with tropomyosin and may be involved in organization of actin filaments. acts as a multicopy suppressor of rho3 mutation. rna-binding protein which may modulate mrna translation. involved in heme regulation of hap1, as a component of the high-molecular-weight complex (hmc).
14361	not known, could be a tyrosine-phosphatase.
14362	collagen type iii occurs in most soft connective tissues along with type i collagen.
14363	
14364	activates cdc42, a member of the ras-like family of rho- and rac proteins, by exchanging bound gdp for free gtp. plays a role in regulating the actin cytoskeleton and cell shape.
14365	
14366	
14367	probably involved in connections of major cytoskeletal structures to the plasma membrane.
14368	probably involved in connections of major cytoskeletal structures to the plasma membrane.
14369	
14370	may be involved in a pathway that regulates neural cell differentiation and proliferation. possible role in neuroectodermal cell-cell interaction.
14371	may be required for normally rapid growth.
14372	receptor that may be a component of a cascade required for development of steroidogenic tissues. acts as a dominant negative regulator of transcription mediated by the retinoic acid receptor.
14373	
14374	binds to mbp1, prevents mbp1-mediated transcriptional repression and antagonizes mbp1-mediated cell death. may play a role in vesicular transport from endoplasmic reticulum to golgi.
14375	
14376	
14377	plays a role in transcriptional coactivation.
14378	may be involved in transcriptional regulation.
14379	
14380	
14381	
14382	
14383	binds to the il-1 type i receptor following il-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mrna stabilization. isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for il-1 signaling. once phosphorylated, irak1 recruits the adapter protein peli1.
14384	may eliminate potentially toxic dinucleoside polyphosphates during sporulation. most active against diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p6-hexaphosphate (ap6a). can also hydrolyze diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p5-pentaphosphate (ap5a), adenosine 5@#$%&-pentaphosphate, and adenosine 5@#$%&-tetraphosphate are also substrates, but not diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p4-tetraphosphate (ap4a) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. also cleaves a beta-phosphate from the diphosphate groups in pp-insp5 (diphosphoinositol pentakisphosphate) and [pp]2-insp4 (bisdiphosphoinositol tetrakisphosphate).
14385	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
14386	
14387	
14388	
14389	
14390	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor yy1; increases yy1 repression activity. required to repress transcription of the pou1f1 transcription factor.
14391	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
14392	not essential for b12 transport; however, it is an auxiliary component of the transport system.
14393	
14394	involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26s proteasome (by similarity).
14395	calcitermin possesses antifungal activity against c.albicans and is also active against e.coli and p.aeruginosa but not l.monocytogenes and s.aureus.
14396	cross-linked envelope protein of keratinocytes. it is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. all that results in the formation of an insoluble envelope beneath the plasma membrane.
14397	the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-coa and co(2). it contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (e1), lipoamide acyltransferase (e2) and lipoamide dehydrogenase (e3).
14398	
14399	calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. receptor propably implicated in the regulation of exocytosis (by similarity).
14400	a potent vasoactive substance which is thought to play a key role in cardiovascular homeostasis. has a cgmp-stimulating activity.
14401	involved in meiotic recombination. required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.
14402	
14403	siii, also known as elongin, is a general transcription elongation factor that increases the rna polymerase ii transcription elongation past template-encoded arresting sites. subunit a is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the siii regulatory subunits b and c (elongin bc complex).
14404	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
14405	
14406	involved in dna repair and mitotic recombination. functions in the recombinational dna repair (rad52) pathway. dissociates rad51 from nucleoprotein filaments formed on dsdna. could be involved in the turnover of rad51 protein-dsdna filaments (by similarity). may play also an essential role in telomere length maintenance and telomere capping in mammalian cells.
14407	
14408	
14409	
14410	ligand for cd2. might facilitate interaction between activated lymphocytes. probably involved in regulating t-cell activation.
14411	
14412	moderately selective excitatory receptor for orexin-a and, with a lower affinity, for orexin-b neuropeptide. seems to be exclusively coupled to the g(q) subclass of heteromeric g proteins, which activates the phospholipase c mediated signaling cascade (by similarity).
14413	
14414	
14415	may be involved in ribosome biogenesis as its disruption leads to increased sensitivity to the antibiotic paromomycin.
14416	activates the metallothionein i promoter. binds to the metal responsive element (mre).
14417	may be involved in transcriptional regulation.
14418	
14419	may be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
14420	
14421	adapter protein involved in neuronal nitric-oxide (no) synthesis regulation via its association with nnos/nos1. the complex formed with nos1 and synapsins is necessary for specific no and synapsin functions at a presynaptic level. mediates an indirect interaction between nos1 and rasd1 leading to enhance the ability of nos1 to activate rasd1. competes with dlg4 for interaction with nos1, possibly affecting nos1 activity by regulating the interaction between nos1 and dlg4 (by similarity).
14422	
14423	
14424	required for protein transport from the er to the golgi complex.
14425	could play a role in neuronal development.
14426	
14427	binds unprenylated rab proteins, presents it to the catalytic rab ggtase dimer, and remains bound to it after the geranylgeranyl transfer reaction. the component a is thought to be regenerated by transferring its prenylated rab back to the donor membrane. less effective than rep-1 in supporting prenylation of rab3 family.
14428	
14429	histone demethylase that specifically demethylates lys-9 and lys-36 residues of histone h3, thereby playing a central role in histone code. does not demethylate histone h3 lys-4, h3 lys-27 nor h4 lys-20. demethylates trimethylated h3 lys-9 and h3 lys-36 residue, while it has no activity on mono- and dimethylated residues. demethylation of lys residue generates formaldehyde and succinate. participates in transcriptional repression of ascl2 and e2f-responsive promoters via the recruitment of histone deacetylases and ncor1, respectively.
14430	
14431	
14432	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. combines rna-binding and ppiase activities. may be involved in muscle- and brain-specific processes.
14433	may be involved in growth regulation in hematopoietic cells.
14434	
14435	not known.
14436	
14437	rna-binding protein. required for internal initiation of translation of human rhinovirus rna. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain.
14438	potential oncogene and regulator of latent hiv.
14439	not known; bind selenium.
14440	
14441	plays a role in neurogenesis and neuronal migration (by similarity). necessary for correct formation of mitotic spindles and chromosome separation during mitosis. necessary for cytokinesis and cell proliferation.
14442	
14443	
14444	
14445	collagen type iv is specific for basement membranes. vital for embryonic development.
14446	a scaffold protein that directs casp3 to certain substrates and facilitates their ordered degradation during apoptosis. may also play a role in mediating casp3 cleavage of krt18. regulates degradation of intermediate filaments during apoptosis. may play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of gtf3c3. inhibits dna transcription in vitro (by similarity).
14447	
14448	
14449	thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity. coactivates six1, and seems to coactivate six2, six4 and six5. the repression of precursor cell proliferation in myoblasts by six1 is switched to activation through recruitment of eya3 to the six1-dach1 complex and seems to be dependent on eya3 phosphatase activity (by similarity). may be involved in development of the eye.
14450	acts as positive regulator of androgen receptor- dependent transcription. may function as redox-sensitive chaperone and as sensor for oxidative stress. prevents aggregation of snca. protects neurons against oxidative stress and cell death. plays a role in fertilization. has no proteolytic activity. has weak transforming activity.
14451	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins that stimulate adenylate cyclase. it has a high affinity for tricyclic psychotropic drugs.
14452	
14453	calcium-dependent mitochondrial solute carrier (by similarity).
14454	
14455	
14456	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
14457	
14458	
14459	
14460	cell surface proteoglycan that may bear heparan sulfate (by similarity).
14461	
14462	
14463	
14464	precursors of the cornified envelope of the stratum corneum.
14465	
14466	promotes the exchange of gsp1/gsp2-bound gdp by gtp. involved in yeast pheromone response pathway and in mrna metabolism. probably involved in the control of nuclear organization.
14467	promotes the exchange of gsp1/gsp2-bound gdp by gtp. involved in yeast pheromone response pathway and in mrna metabolism. probably involved in the control of nuclear organization.
14468	may be involved in transcriptional regulation.
14469	
14470	
14471	catalyzes the production of gaba.
14472	
14473	
14474	
14475	
14476	
14477	transcriptional activator which binds to the enhancer of the t-cell receptor alpha and delta genes. binds to the consensus sequence 5@#$%&-agatag-3@#$%&.
14478	
14479	interacts with guanosine triphosphate (gtp)-bound forms of rab6a and rab6b. may act as a motor required for the retrograde rab6 regulated transport of golgi membranes and associated vesicles along microtubles. has a microtubule plus end-directed motility.
14480	binds to the transactivation domain of the adenovirus type 5 e1a 32 kda protein (289r) and inhibits its transactivating activity. may act as tumor suppressor through suppression of adenovirus replication.
14481	
14482	
14483	
14484	important for structural integrity of the central apparatus in the sperm tail and for flagellar motility (by similarity).
14485	
14486	
14487	mrs4 suppresses a mitochondrial splice defect in the first intron of the cob gene. it may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). not essential.
14488	
14489	may play a role in vesicular protein sorting, similar to the yeast retromer proteins.
14490	
14491	forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. the channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mv. the open state has a weak anion selectivity whereas the closed state is cation- selective.
14492	may regulate vesicle function in the growth cone (by similarity).
14493	delivers retinol from the liver stores to the peripheral tissues. in plasma, the rbp-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
14494	probable atpase involved in the assembly or function of nuclear protein complexes. may also be involved in some aspects of microtubule dynamics (by similarity).
14495	
14496	gtpase activator for the rho-type gtpases by converting them to an inactive gdp-bound state (by similarity).
14497	
14498	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. probably binds g- rich sequences in pre-mrnas.
14499	the h2 subclass of histamine receptors mediates gastric acid secretion. also appears to regulate gastrointestinal motility and intestinal secretion. possible role in regulating cell growth and differentiation. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase and, through a separate g protein-dependent mechanism, the phosphoinositide/protein kinase (pkc) signaling pathway (by similarity).
14500	
14501	part of the proton channel of v-atpases (by similarity).
14502	cellular negative regulator of the hepatitis b virus (hbv) x protein.
14503	
14504	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
14505	may be involved in regulating membrane trafficking in the endosomal pathway. overexpression induces endosome aggregation. required to target tom1 to endosomes.
14506	
14507	
14508	
14509	may be a mediator of metastasis suppression in breast carcinoma (by similarity).
14510	may regulate the disassembly of focal adhesions. may localize receptor-like tyrosine phosphatases type 2a at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
14511	may regulate the disassembly of focal adhesions. may localize receptor-like tyrosine phosphatases type 2a at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
14512	
14513	
14514	
14515	cytokine that can act as a growth factor for activated t and nk cells, enhance the lytic activity of nk/lymphokine- activated killer cells, and stimulate the production of ifn-gamma by resting pbmc.
14516	muscle contraction.
14517	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex.
14518	minor apolipoprotein mainly associated with hdl and to a lesser extent with vldl. may also be associated with chylomicrons. important determinant of plasma triglyceride (tg) levels by both being a potent stimulator of apo-cii lipoprotein lipase (lpl) tg hydrolysis and a inhibitor of the hepatic vldl-tg production rate (without affecting the vldl-apob production rate) (by similarity). activates poorly lecithin:cholesterol acyltransferase (lcat) and does not enhance efflux of cholesterol from macrophages.
14519	has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. may play a role as a molecular chaperone and participate in protein folding.
14520	catalyzes the covalent attachment of ubiquitin to other proteins. functions in the e6/e6-ap-induced ubiquitination of p53/tp53.
14521	
14522	binds to the fc region of immunoglobulins epsilon. high affinity receptor. responsible for initiating the allergic response. binding of allergen to receptor-bound ige leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. the same receptor also induces the secretion of important lymphokines.
14523	
14524	
14525	
14526	
14527	involved in normal and neoplastic cell growth.
14528	transcriptional activator involved in t-cell lymphocyte differentiation. necessary for the survival of cd4(+) cd8(+) immature thymocytes. isoforms lacking the n-terminal ctnnb1 binding domain cannot fulfill this role. binds to the t- lymphocyte-specific enhancer element (5@#$%&-wwcaaag-3@#$%&) found in the promoter of the cd3e gene. may also act as feedback transcriptional repressor of ctnnb1 and tcf7l2 target genes. tle1, tle2, tle3 and tle4 repress transactivation mediated by tcf7 and ctnnb1.
14529	
14530	regulator of vesicular trafficking process. required for the sorting of endocytic (egf receptors) cargos. also involved in exocytic cargos of viral proteins of hiv-1 virus. in case of infection by hiv-1 virus, it is recruited to and functions at sites of viral gag assembly and budding. may be involved in cell growth and differentiation. acts as a negative growth regulator.
14531	
14532	
14533	component of the signaling pathway of il-1 and toll-like receptors. inhibits cell activation by microbial products. recruits irak1 to the il-1 receptor complex. inhibits irak1 phosphorylation and kinase activity.
14534	could be involved in the hypothalamic regulation of body weight.
14535	adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. also involved in the il-1 signaling pathway via myd88 and irak kinases. seems to be involved in il-17 signaling (by similarity). mediates activation of nf-kappa-b and jnk. may function as an e3 ubiquitin ligase.
14536	
14537	
14538	may function as a regulatory atpase and be related to secretion/protein trafficking process.
14539	the activated kinase acts on a variety of targets. likely to be the gtpase effector that links the rho-related gtpases to the jnk map kinase pathway. activated by cdc42 and rac1. involved in dissolution of stress fibers and reorganization of focal complexes. activity is inhibited in cells undergoing apoptosis, potentially due to binding of cdc2l1 and cdc2l2.
14540	binds specifically to collagen. could be involved as a chaperone in the biosynthetic pathway of collagen.
14541	couples tyrosine kinase signals with the activation of the rho/rac gtpases, thus leading to cell differentiation and/or proliferation.
14542	probably involved in cell adhesion. receptor for alphaherpesvirus (hsv-1, hsv-2 and pseudorabies virus) entry into cells.
14543	
14544	modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. may play a role in synapse formation during brain development.
14545	
14546	
14547	signal transducer and activator of transcription that mediates signaling by type i ifns (ifn-alpha and ifn-beta). following type i ifn binding to cell surface receptors, jak kinases (tyk2 and jak1) are activated, leading to tyrosine phosphorylation of stat1 and stat2. the phosphorylated stats dimerize, associate with isgf3g/irf-9 to form a complex termed isgf3 transcription factor, that enters the nucleus. isgf3 binds to the ifn stimulated response element (isre) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
14548	
14549	secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.
14550	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
14551	may be involved in transcriptional regulation.
14552	
14553	
14554	acts as a transcriptional repressor for zinc finger transcription factors egr1 and egr2. isoform 2 lacks repression ability (by similarity).
14555	binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
14556	survival-promoting peptide promotes survival of neurons and displays phosphatase activity. it may bind igg.
14557	protein transport. probably involved with ras-related protein rab-3a in synaptic vesicle traffic and/or synaptic vesicle fusion. could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (by similarity).
14558	mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient.
14559	
14560	receptor that may play a role in the perception of bitterness and is gustducin-linked. may play a role in sensing the chemical composition of the gastrointestinal content. the activity of this receptor may stimulate alpha gustducin, mediate plc-beta-2 activation and lead to the gating of trpm5 (by similarity).
14561	receptor for the e.coli heat-stable enterotoxin (e.coli enterotoxin markedly stimulates the accumulation of cgmp in mammalian cells expressing gc-c). also activated by the endogenous peptide guanylin.
14562	in vitro, phosphorylates ptdins and ptdins4p but not ptdins(4,5)p2 (by similarity).
14563	
14564	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
14565	regulatory protein, which plays a central role in chromosome stability, in the p53/tp53 pathway, and dna repair. probably acts by blocking the action of key proteins. during the mitosis, it blocks separase/espl1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. at the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of espl1. its function is however not limited to a blocking activity, since it is required to activate espl1. negatively regulates the transcriptional activity and related apoptosis activity of tp53. the negative regulation of tp53 may explain the strong transforming capability of the protein when it is overexpressed. may also play a role in dna repair via its interaction with ku, possibly by connecting dna damage-response pathways with sister chromatid separation.
14566	involved in platelet activation and aggregation. regulates paranodal junction formation. required for gamete fusion. involved in cell adhesion, cell motility and tumor metastasis.
14567	transports betaine and gaba. may have a role in regulation of gabaergic transmission in the brain through the reuptake of gaba into presynaptic terminals, as well as in osmotic regulation.
14568	
14569	
14570	
14571	
14572	involved in muscle differentiation (myogenic factor). induces fibroblasts to differentiate into myoblasts. probable sequence specific dna-binding protein.
14573	
14574	
14575	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
14576	may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. when overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor (n-linked palmitoyl- (c16) ceramide) in a fumonisin b1-independent manner (by similarity).
14577	integrin alpha-4/beta-7 (peyer patches-specific homing receptor lpam-1) is expected to play a role in adhesive interactions of leukocytes. it is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced cs-1 region of fibronectin. integrin alpha-4/beta-7 is also a receptor for madcam1 and vcam1. it recognizes the sequence l-d-t in madcam1. integrin alpha-e/beta-7 (hml-1) is a receptor for e- cadherin.
14578	regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. confers calcium sensitivity.
14579	
14580	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone (by similarity).
14581	may play a role in apoptosis. may act as a tumor suppressor.
14582	
14583	required for normal vision and courtship behavior in drosophila.
14584	involved in regulating eumelanin and phaeomelanin levels.
14585	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (by similarity). probably encodes a dihydropyridine-insensitive current. vital for survival to adulthood.
14586	involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.
14587	
14588	
14589	ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. this enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the c-terminal glycine of either ubiquitin or nedd8.
14590	involved in microtubule organization by the microtubule organizing center, the spindle pole body (spb). probably part of the microtubule attachment site at the spb.
14591	kinase that may play a role in mitotic regulation.
14592	
14593	
14594	
14595	serine/threonine kinase that phosphorylates thr-18 of p53/tp53 and may thereby prevent the interaction between p53/tp53 and mdm2.
14596	regulates chordin (chrd). may play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis.
14597	essential component of nuclear pore complex. nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport (by similarity).
14598	required maternally for proper expression of other homeotic genes involved in pattern formation, such as ubx.
14599	plays an important role in the de novo pathway of purine nucleotide biosynthesis (by similarity).
14600	
14601	
14602	
14603	
14604	
14605	may be involved in limb tendon and ligament development (by similarity).
14606	mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. may also be required for the transfer of beta-barrel precursors from the tom complex to the sorting and assembly machinery (sam complex) of the outer membrane. acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
14607	may participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.
14608	
14609	
14610	may be involved in several stages of intracellular trafficking.
14611	plays a role in valine and pyrimidine metabolism. binds fatty acyl-coa (by similarity).
14612	growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. it binds to receptor vegfr-1/flt1. plgf-2 binds neuropilin-1 and 2 in a heparin-dependent manner.
14613	angiogenesis inhibitor. inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. this inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. acts in an autocrine manner.
14614	binds the telomeric double-stranded ttaggg repeat and negatively regulates telomere length. involved in the regulation of the mitotic spindle.
14615	
14616	mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.
14617	
14618	
14619	transcriptional repressor of the myelin basic protein gene (mbp). binds to the proximal mb1 element 5@#$%&-ttgtcc-3@#$%& of the mbp promoter. its binding to mb1 and function are inhibited by pura (by similarity).
14620	
14621	
14622	
14623	
14624	
14625	
14626	
14627	
14628	stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
14629	
14630	
14631	
14632	plays a fundamental role in microtubule-organizing center structure and function.
14633	
14634	mediates tetrahydrobiopterin inhibition of gtp cyclohydrolase i. this inhibition is reversed by l-phenylalanine (by similarity).
14635	seems to specifically modulate the transactivation activity of wt1.
14636	
14637	
14638	
14639	guanine nucleotide exchange factor (gef) for rab-3 and cab-1. novel regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release. is also a regulator of the cab-1 synaptic transmission pathway.
14640	
14641	regulates the differentiation and proliferation of normal cells through the regulation of cell death.
14642	unknown, though mvp is required for normal vault structure. vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport.
14643	methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
14644	methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
14645	
14646	
14647	
14648	regulatory subunit of the dimeric ube1c-appbp1 e1 enzyme. e1 activates nedd8 by first adenylating its c-terminal glycine residue with atp, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-ube1c thioester and free amp. e1 finally transfers nedd8 to the catalytic cysteine of ube2m. necessary for cell cycle progression through the s-m checkpoint. overexpression of appbp1 causes apoptosis through deregulation of nedd8 conjugation.
14649	
14650	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
14651	may be an ion-channel regulator. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis. involved in adhesive protein-protein and protein-carbohydrate interactions.
14652	can act as repulsive axon guidance cues. may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (by similarity).
14653	may play a role in cellular adhesion. antigenic protein reactive with antibody k1.
14654	
14655	involved in the trafficking of secretory vesicles from the endoplasmic reticulum (er) to the golgi. regulates correct targeting and tethering of vesicles to target membranes by catalyzing the selective recruitment of proteins required for tethering and fusion onto membranes. vesicular transport depends on shuttling of ypt1 between membrane and cytosol by gdi1, probably by recycling it to its membrane of origin after a vesicle fusion event. required for sorting and transport of proteins from the er through the golgi compartment. also involved in the recycling of membrane proteins.
14656	
14657	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna.
14658	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna.
14659	
14660	
14661	
14662	it may be responsible for the synthesis of the sequence neuac-alpha-2,3-gal-beta-1,3-galnac- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. siat4a and siat4b sialylate the same acceptor substrates but exhibit different km values.
14663	
14664	electrically silent transporter system. mediates sodium and chloride reabsorption.
14665	
14666	phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin i. this isozyme may regulate glycogeneolysis in the testis.
14667	
14668	docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. implicated in induction of cell migration. overexpression confers antiestrogen resistance on breast cancer cells.
14669	binds thyroid hormone. presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.
14670	receptor for the hormone galanin and for galp. the activity of this receptor is mediated by g proteins that activate the phospholipase c/protein kinase c pathway (via gq) and that inhibit adenylyl cyclase (via gi).
14671	necessary for the splicing of pre-mrna. it is required for formation of the earliest atp-dependent splicing complex and interacts with spliceosomal components bound to both the 5@#$%& and 3@#$%& splice sites during spliceosome assembly. it also is required for atp-dependent interactions of both u1 and u2 snrnps with pre-mrna. interacts with other spliceosomal components, via the rs domains, to form a bridge between the 5@#$%& and 3@#$%& splice site binding components, u1 snrnp and u2af. binds to purine-rich rna sequences, either 5@#$%&-agsagagta-3@#$%& (s=c or g) or 5@#$%&-gttcgagta-3@#$%&. can bind to beta-globin mrna and commit it to the splicing pathway.
14672	
14673	putative odorant receptor.
14674	may be involved in neuronal differentiation.
14675	deglycating enzyme which phosphorylates the third carbon of the sugar moiety of ketosamines. may play a role in freeing proteins from ribulosamines or psicosamines.
14676	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex. it has no apparent bacterial homolog and its exact function is unknown.
14677	
14678	
14679	
14680	type i collagen is a member of group i collagen (fibrillar forming collagen).
14681	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
14682	catalyzes the transfer of ptdins and phosphatidylcholine between membranes.
14683	
14684	
14685	transfers a sulfuryl group to an n-unsubstituted glucosamine linked to a 2-o-sulfo iduronic acid unit on heparan sulfate. catalyzes the o-sulfation of glucosamine in idoua2s-glcns and also in idoua2s-glcnh2. the substrate-specific o-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to herpes simplex virus-1 (hsv-1) and permits its entry. unlike 3-ost-1, does not convert nonanticoagulant heparan sulfate to anticoagulant heparan sulfate.
14686	muscle contraction.
14687	integrin alpha-iib/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. it recognizes the sequence r-g-d in a wide array of ligands. it recognizes the sequence h-h-l-g-g-g-a-k-q-a-g-d-v in fibrinogen gamma chain. following activation integrin alpha- iib/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. this step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
14688	band 3 is the major integral glycoprotein of the erythrocyte membrane. band 3 has two functional domains. its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin.
14689	
14690	tubulin is the major constituent of microtubules. gamma tubulin is found at microtubule organizing centers (mtoc) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
14691	
14692	
14693	
14694	
14695	may complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.
14696	somatomedin b is a growth hormone-dependent serum factor with protease-inhibiting activity.
14697	
14698	
14699	
14700	rab effector protein acting as linker between gamma- adaptin, rab4a and rab5a. involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. stimulates rabgef1 mediated nucleotide exchange on rab5a.
14701	
14702	
14703	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii is composed of at least five proteins: the sec23/24 complex, the sec13/31 complex, and the protein sar1. acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex (by similarity).
14704	since they lack a putative transactivation domain, the small mafs behave as transcriptional repressors when they dimerize among themselves. however, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific dna-binding sites. small maf proteins heterodimerize with fos and may act as competitive repressors of the nf-e2 transcription factor. transcription factor, component of erythroid-specific transcription factor nf- e2. activates globin gene expression when associated with nf-e2.
14705	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
14706	
14707	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii is composed of at least five proteins: the sec23/24 complex, the sec13/31 complex, and the protein sar1. acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex (by similarity).
14708	
14709	
14710	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
14711	
14712	activates erythroid-specific, globin gene expression.
14713	functions as a component of the nuclear pore complex (npc). npc components, collectively referred to as nucleoporins (nups), can play the role of both npc structural components and of docking or interaction partners for transiently associated nuclear transport factors. involved in nuclear poly(a)+ rna export and npc biogenesis, it is also required for normal nuclear morphology.
14714	receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic t-lymphocyte (ctl).
14715	mannose-specific lectin. may recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. the lman1-mcfd2 complex forms a specific cargo receptor for the er-to-golgi transport of selected proteins.
14716	receptor for members of the ephrin-a family. binds to ephrin-a1, -a2, -a3, -a4 and -a5.
14717	
14718	
14719	may transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid of n-linked oligosaccharides of glycoproteins and glycolipids. it can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.
14720	
14721	has phospholipase and triglyceride lipase activities. hydrolyzes high density lipoproteins (hdl) more efficiently than other lipoproteins. binds heparin.
14722	
14723	may be involved in transcriptional regulation.
14724	
14725	
14726	may be involved in transcriptional regulation.
14727	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
14728	has an atp-independent isopeptidase activity, cleaving at the c-terminus of the ubiquitin moiety. function late in the proteolytic pathway in conjunction with the 26s proteasome. plays a role in avoiding dna overreplication.
14729	has an atp-independent isopeptidase activity, cleaving at the c-terminus of the ubiquitin moiety. function late in the proteolytic pathway in conjunction with the 26s proteasome. plays a role in avoiding dna overreplication.
14730	probably functions as an alternative splicing regulator. may regulate the mrna splicing of genes such as clk1. may act by regulating members of the clk kinase family (by similarity).
14731	probably functions as an alternative splicing regulator. may regulate the mrna splicing of genes such as clk1. may act by regulating members of the clk kinase family (by similarity).
14732	
14733	
14734	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-golgi network (tgn) and endosomes. the ap complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
14735	
14736	
14737	connects the two cox monomers into the physiological dimeric form (by similarity).
14738	is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. bioactivates 3-methylindole (3mi) by dehydrogenation to the putative electrophile 3-methylene- indolenine.
14739	
14740	
14741	dual specificity kinase that activates the jun kinases mapk8 (jnk1) and mapk9 (jnk2).
14742	
14743	may have a potential role in hypercalcemia of malignancy (by similarity).
14744	
14745	
14746	acts as a factor that allows the dna to undergo a single round of replication per cell cycle. required for dna replication and cell proliferation.
14747	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (by similarity).
14748	stimulates the proliferation of early hematopoietic cells. synergizes well with a number of other colony stimulating factors and interleukins.
14749	
14750	may play a role in germ line formation.
14751	major calcium-binding protein of the golgi. may have a role in calcium homeostasis (by similarity).
14752	does not have a catalytic activity.
14753	
14754	this is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.
14755	specific component of the tight junction (tj) plaque, but might not be an exclusively junctional component. may have a house-keeping rule. may be required for pre-mrna polyadenylation.
14756	
14757	may be involved in transcriptional regulation.
14758	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis. regulates the ca(2+)- dependent secretion of norepinephrine in pc12 cells. required for export from the endocytic recycling compartment to the cell surface (by similarity).
14759	communication between transverse-tubules and sarcoplasmic reticulum. contraction of skeletal muscle is triggered by release of calcium ions from sr following depolarization of t-tubules.
14760	
14761	fibrillarin is a component of a nucleolar small nuclear ribonucleoprotein particle thought to participate in the first step in processing preribosomal rna. it is associated with the u3, u8 and u13 small nuclear rnas.
14762	fibrillarin is a component of a nucleolar small nuclear ribonucleoprotein particle thought to participate in the first step in processing preribosomal rna. it is associated with the u3, u8 and u13 small nuclear rnas.
14763	type i collagen is a member of group i collagen (fibrillar forming collagen).
14764	may be involved in transcriptional regulation.
14765	this glycoprotein, produced by the sertoli cells of the testis, causes regression of the muellerian duct. it is also able to inhibit the growth of tumors derived from tissues of muellerian duct origin.
14766	plays a role in membrane ruffling and assembly of clathrin-coated pits at the synapse. mediates rac1-dependent reorganization of actin filaments (by similarity). participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
14767	may play a role in the regulation of ionic transport. binds calcium.
14768	acts preferentially on the c-jun n-terminal kinase (jnk) and p38 mapks. plays an important role in the heavy metal stress response by negatively regulating the kgb-1 (jnk-like) and the pmk-1 (p38-type) mapk signaling pathways.
14769	
14770	has a beta1,3-n-acetylglucosaminyltransferase activity for type 2 oligosaccharides.
14771	may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. when overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor (n-linked stearoyl- (c18) ceramide) in a fumonisin b1-independent manner (by similarity).
14772	
14773	
14774	inhibitory regulator of the ras-cyclic amp pathway.
14775	inhibits nf-kappa-b by complexing with and trapping it in the cytoplasm. however, the unphosphorylated form resynthesized after cell stimulation is able to bind nf-kappa-b allowing its transport to the nucleus and protecting it to further ikba- dependent inactivation. association with inhibitor kappa b- interacting nkiras1 and nkiras2 prevent its phosphorylation rendering it more resistant to degradation, explaining its the slower degradation.
14776	may act as soluble receptor for class i mhc antigens.
14777	
14778	
14779	required for membrane traffic to the vacuole.
14780	required for membrane traffic to the vacuole.
14781	may be involved in transcriptional regulation.
14782	orphan receptor.
14783	may be important for the development of vital and immunocompetent organs.
14784	binds medium- and long-chain acyl-coa esters with very high affinity and may function as an intracellular carrier of acyl-coa esters. it is also able to displace diazepam from the benzodiazepine (bzd) recognition site located on the gaba type a receptor. it is therefore possible that this protein also acts as a neuropeptide to modulate the action of the gaba receptor.
14785	lph splits lactose in the small intestine.
14786	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. receptor for activin.
14787	this protein binds the camp response element (cre), a sequence present in many viral and cellular promoters. creb stimulates transcription on binding to the cre.
14788	
14789	has a higher affinity for cgmp than for camp.
14790	
14791	
14792	activator of cdk5/tpkii.
14793	
14794	may play a regulatory role in synaptic vesicle recycling.
14795	receptor for interleukin-1 alpha (il-1a), beta (il-1b), and interleukin-1 receptor antagonist protein (il-1ra).
14796	
14797	together with the ste20-related adaptor-alpha (strad alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of stk11.
14798	
14799	
14800	gtpase-activating protein for p21-rac and a phorbol ester receptor. may play an important role in neuronal signal- transduction mechanisms.
14801	
14802	
14803	component of the escrt-iii complex, which is required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs. the mvb pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. the escrt-iii complex is probably involved in the concentration of mvb cargo. required for sorting/trafficking of egf receptor. in case of infection, the hiv-1 virus takes advantage of the escrt-iii complex for budding and exocytic cargos of viral proteins.
14804	produced by activated macrophages, il-1 stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. il-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
14805	
14806	this protein binds free fatty acids and their coenzyme a derivatives, bilirubin, and some other small molecules in the cytoplasm; it may be involved in intracellular lipid transport.
14807	catalyzes the methylation of glycine by using s- adenosylmethionine (adomet) to form n-methylglycine (sarcosine) with the concomitant production of s-adenosylhomocysteine (adohcy). possible crucial role in the regulation of tissue concentration of adomet and of metabolism of methionine.
14808	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation via its interaction with the myocyte enhancer factors such as mef2a, mef2c and mef2d.
14809	
14810	apolipoprotein b is a major protein constituent of chylomicrons (apo b-48), ldl (apo b-100) and vldl (apo b-100). apo b-100 functions as a recognition signal for the cellular binding and internalization of ldl particles by the apob/e receptor.
14811	
14812	ppiases accelerate the folding of proteins during protein synthesis.
14813	hydrolyzes a variety of proteins.
14814	
14815	
14816	
14817	component of the cop9 signalosome complex (csn), a complex involved in various cellular and developmental processes. the csn complex is an essential regulator of the ubiquitin (ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of scf-type e3 ligase complexes, leading to decrease the ubl ligase activity of scf-type complexes such as scf, csa or ddb2. the complex is also involved in phosphorylation of p53/tp53, c-jun/jun, ikappabalpha/nfkbia, itpk1 and irf8/icsbp, possibly via its association with ck2 and pkd kinases. csn-dependent phosphorylation of tp53 and jun promotes and protects degradation by the ubl system, respectively.
14818	
14819	histones h1 are necessary for the condensation of nucleosome chains into higher order structures.
14820	involved in the activation cascade of caspases responsible for apoptosis execution. at the onset of apoptosis it proteolytically cleaves poly(adp-ribose) polymerase (parp) at a 216-asp-|-gly-217 bond. cleaves and activates sterol regulatory element binding proteins (srebps) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. cleaves and activates caspase-6, -7 and -9. involved in the cleavage of huntingtin.
14821	
14822	
14823	collagen type ii is specific for cartilaginous tissues. it is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
14824	
14825	
14826	
14827	may function in the secretion of milk-fat droplets. may act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (by similarity).
14828	binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
14829	plays an important role in control of proteasome function. inhibits the hydrolysis of protein and peptide substrates by the 20s proteasome. also inhibits the activation of the proteasome by the proteasome regulatory proteins pa700 and pa28.
14830	required for 60s ribosomal subunit biogenesis.
14831	
14832	
14833	involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.
14834	performs a specialized role during sperm development and maturation.
14835	might support glycosylation reactions in the golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. hydrolyzes preferentially nucleoside 5@#$%&-diphosphates, nucleoside 5@#$%&-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5@#$%&-monophosphates. the order of activity with different substrates is gdp > idp >> udp = cdp >> adp (by similarity).
14836	implicated in the level of global muscle contraction and cardiac function. phosphorylates a specific serine in the n- terminus of a myosin light chain.
14837	
14838	binds activated protein c. enhances protein c activation by the thrombin-thrombomodulin complex; plays a role in the protein c pathway controlling blood coagulation.
14839	
14840	makes part of tfiid is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. potentiates transcriptional activation by the af-2s of the retinoic acid, vitamin d3 and thyroid hormone.
14841	overexpression impairs serum-induced cell cycle progression from the g0/g1 to s phase.
14842	
14843	
14844	
14845	
14846	
14847	
14848	probably methylates the guanidino nitrogens of arginyl residues in some proteins. may play a role in transcriptional coactivation.
14849	probable protease. seems to be capable of activating enac.
14850	
14851	
14852	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
14853	
14854	may be an important signaling intermediate between tgfb receptors and map3k7/tak1. may play an important role in mammalian embryogenesis.
14855	
14856	binds to the 5@#$%&stem-loop of u4 snrna and may play a role in the late stage of spliceosome assembly. the protein undergoes a conformational change upon rna-binding.
14857	
14858	
14859	
14860	
14861	
14862	high affinity receptor for triiodothyronine.
14863	probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. may also participate in functions of the mature nervous system.
14864	
14865	intracellular transport of retinol.
14866	receptor for slit1 and slit2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. in axon growth cones, the silencing of the attractive effect of ntn1 by slit2 may require the formation of a robo1-dcc complex. may be required for lung development.
14867	may mediate accelerated atp-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
14868	
14869	
14870	
14871	inhibitory regulator of the ras-cyclic amp pathway. binds inositol tetrakisphosphate (ip4).
14872	arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
14873	
14874	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
14875	
14876	binds to the il-1 type i receptor following il-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mrna stabilization.
14877	
14878	
14879	
14880	possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane (by similarity).
14881	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes.
14882	
14883	
14884	has gtpase activity. may mediate the membrane association of sr alpha (by similarity).
14885	
14886	
14887	
14888	
14889	
14890	
14891	
14892	lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.
14893	
14894	required for assembly of the mitotic spindle. interact with spindle microtubules to produce an outwardly directed force acting upon the poles. following spindle assembly, cin8 and kip1 apparently act to oppose a force that draws separated poles back together. this force seems to be mediate by kar3.
14895	
14896	
14897	
14898	sulfate transporter. may play a role in endochondral bone formation.
14899	
14900	
14901	
14902	possible adhesion molecule with a role in early hematopoiesis by mediating attachment to stromal cells. influences the survival and/or proliferation of b-cell precursors. binding to cells requires mn(2+) (by similarity).
14903	negatively regulates bone density. antagonizes the ability of certain osteogenic bmps to induce osteoprogenitor differentitation and ossification.
14904	
14905	
14906	
14907	
14908	component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity.
14909	converts pro-anp to anp. cleaves pro-anp specifically between arg-123 and ser-124.
14910	
14911	
14912	
14913	
14914	
14915	
14916	
14917	
14918	
14919	
14920	core tafii present in both of the previously described tfiid species which either lack or contain tafii30 (tfiid alpha and tfiid beta respectively).
14921	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
14922	
14923	guanine nucleotide exchange factor that interacts with rhoa, but not with rac or cdc42. activates rhoa to promote cytoskeletal contraction and inhibit neurite outgrowth.
14924	participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. also cleaves alpha-2 macroglobulin. may be involved in osteoblast differenciation and/or osteoblast activity in bone (by similarity).
14925	may be involved in transcriptional regulation.
14926	
14927	adapter protein which binds ubiquitin and may regulate the activation of nfkb1 by tnf-alpha, nerve growth factor (ngf) and interleukin-1. may play a role in titin/ttn downstream signaling in muscle cells. may regulate signaling cascades through ubiquitination. may be involved in cell differentiation, apoptosis, immune response and regulation of k(+) channels.
14928	
14929	enterostatin has a biological activity as a satiety signal.
14930	
14931	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
14932	
14933	
14934	could function as a cell-adhesion protein. acts as a tumor suppressor. required for correct morphogenesis.
14935	
14936	involved in the regulation of homocysteine metabolism. converts betaine and homocysteine to dimethylglycine and methionine, respectively. this reaction is also required for the irreversible oxidation of choline.
14937	this protein participates in processes of transmission and amplification of the visual signal.
14938	signal-recognition-particle assembly, binds directly to 7s rna and mediates binding of the 54 kda subunit of the srp.
14939	promotes the exchange of gdp by gtp. may act as part of a signal transduction system linking the catalytic domains of pam in the lumen of the secretory pathway to cytosolic factors regulating the cytoskeleton and signal transduction pathways.
14940	
14941	
14942	appears to be required for normal postnatal skeletal growth and cartilage homeostasis.
14943	receptor that is activated by both amino acids and extracellular concentration of calcium ions. the activity of this receptor is mediated by a g-protein that activates a phosphatidylinositol-calcium second messenger system. senses changes in the extracellular concentration of calcium ions, suggesting that it may mediate extracellular calcium-sensing responses in osteoblasts. osteocalin, stimulates its activity in presence of calcium. has a lower affinity for calcium than casr. also acts as a receptor for amino acids, with a preference for basic amino acids such as l-lys, l-arg and l-ornithine. its affinity for amino acids suggests that it may act as a regulatory component of the urea cycle.
14944	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
14945	
14946	
14947	shows weak transcriptional activatory activity. transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide.
14948	
14949	protein tyrosine phosphatase which stimulates progression from g1 into s phase during mitosis. may play a role in the development and maintenance of differentiating epithelial tissues. enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
14950	growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. binds to the vegfr1/flt-1 and vegfr2/kdr receptors, heparan sulfate and heparin. neuropilin-1 binds isoforms vegf-165 and vegf-145.
14951	
14952	
14953	
14954	
14955	may contribute to the development of sarcomas.
14956	
14957	in response to ifn-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin f2-alpha (pgf), and thus prevent lysis of the corpus luteum and maintain the pregnancy.
14958	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
14959	
14960	
14961	
14962	
14963	
14964	
14965	transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (@#$%&gcat@#$%&) and (@#$%&taat@#$%&), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. positively regulates the genes under the control of corticotropin-releasing hormone (crh) and crh ii promoters (by similarity).
14966	
14967	
14968	
14969	
14970	
14971	
14972	may be involved in transcriptional regulation.
14973	
14974	converts sphingomyelin to ceramide. hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-pc) and 1-o-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). the physiological substrate seems to be lyso-paf.
14975	transcriptional activator that binds with high affinity to the t-cell enhancer motif 5@#$%&-aacaaag-3@#$%& motif.
14976	
14977	catalyzes the formation of an hydroxyacyl-coa by addition of water on enoyl-coa. also exhibits 3-hydroxyacyl-coa epimerase and 3-hydroxyacyl-coa dehydrogenase activities. involved in the aerobic and anaerobic degradation of long-chain fatty acids.
14978	
14979	
14980	type i collagen is a member of group i collagen (fibrillar forming collagen).
14981	
14982	during embryonic development, some isoforms are essential for proper neuronal differentiation and organization. required for cell polarity; maintenance of apicobasal polarity. plays a critical role at septate junctions in cellular growth control during larval development. the presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
14983	calcium-dependent mitochondrial aspartate and glutamate carrier. may have a function in the urea cycle.
14984	
14985	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to sites in the 5@#$%&-flanking sequence of its coding region with various affinities. the consensus sequences of the high and low affinity binding sites are 5@#$%&-taatga[cg]-3@#$%& and 5@#$%&-ctaatttt- 3@#$%&.
14986	calcium channel protein which plays an important role in excitation-contraction coupling.
14987	
14988	
14989	
14990	
14991	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
14992	
14993	
14994	
14995	
14996	
14997	
14998	stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers (by similarity).
14999	acts as a positive regulator of apoptosis.
15000	
15001	
15002	likely to play role in the modification of cellular properties that underlie long-term plasticity. binds to agar matrix in a calcium-dependent manner (by similarity).
15003	
15004	binds the poly(a) tail of mrna. may be involved in cytoplasmic regulatory processes of mrna metabolism. its function in translational initiation regulation can either be enhanced by paip1 or repressed by paip2. can probably bind to cytoplasmic rna sequences other than poly(a) in vivo. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain.
15005	involved in dna repair and mitotic recombination. may play an active role in recombination processes in concert with other members of the rad52 epistasis group.
15006	
15007	probable transcriptional activator in the premeiotic germ cells. it binds to the sequences 5@#$%&-aacaat-@#$%&3 or 5@#$%&-aacaaag- 3@#$%& (by similarity).
15008	receptor for interferon gamma. two receptors bind one interferon gamma dimer.
15009	probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation during skeletal muscle atrophy.
15010	
15011	
15012	may be involved in meiosis or the maturation of germ cells.
15013	converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single arg-val bond in plasminogen. by controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. play a direct role in facilitating neuronal migration.
15014	has antimicrobial activity.
15015	
15016	immediate-early protein likely to play a role in cell growth regulation (by similarity).
15017	promotes guanine-nucleotide exchange on arf1 and arf3. promotes the activation of arf1/arf3 through replacement of gdp with gtp.
15018	
15019	transcriptional activator. recognizes and binds to the dna sequence 5@#$%&-tgt[gt][gt]att-3@#$%&. required for induction of the goosecoid (gsc) promoter by tgf-beta or activin signaling. forms a transcriptionally active complex containing fast-1/smad2/smad4 on a site on the gsc promoter called tare (tgf-beta/activin response element) (by similarity).
15020	
15021	
15022	induces bone formation in conjunction with tgf-beta-1 or tgf-beta-2.
15023	
15024	negatively regulates matrix metalloproteinase-9 (mmp-9) by suppressing mmp-9 secretion and by direct inhibition of its enzymatic activity. reck down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. appears to also regulate mmp-2 and mt1-mmp, which are involved in cancer progression.
15025	necessary for the fragmentation of golgi stacks during mitosis and for their reassembly after mitosis. involved in the formation of the transitional endoplasmic reticulum (ter). the transfer of membranes from the endoplasmic reticulum to the golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (ter). vesicle budding from the ter is an atp-dependent process. the ternary complex containing ufd1l, vcp and nploc4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the er to the cytoplasm, where they are degraded by the proteasome. the nploc4-ufd1l-vcp complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (by similarity).
15026	resistance to tetracycline by an active tetracycline efflux. this is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. this protein functions as a metal-tetracycline/h(+) antiporter.
15027	transcriptional corepressor that binds to a number of transcription factors. inhibits the transcriptional activation mediated by pax5, and by ctnnb1 and tcf family members in wnt signaling. the effects of full-length tle family members may be modulated by association with dominant-negative aes (by similarity).
15028	binds free retinal and cellular retinol-binding protein- bound retinal. can convert/oxidize retinaldehyde to retinoic acid (by similarity).
15029	may be the negative regulator of ets1 and may inhibit nuclear factor-kappab activation.
15030	
15031	specific growth arrest protein involved in growth suppression. blocks entry to s phase. prevents cycling of normal and transformed cells.
15032	
15033	
15034	
15035	jana and janb regulate somatic sex differentiation.
15036	
15037	
15038	cleaves dna at double-stranded (dg)n.(dc)n and at single-stranded (dc)n tracts. in addition to deoxyribonuclease activities, also has ribonuclease (rnase) and rnase h activities. capable of generating the rna primers required by dna polymerase gamma to initiate replication of mitochondrial dna (by similarity).
15039	receptor for interleukin-11. the receptor systems for il6, lif, osm, cntf, il11 and ct1 can utilize il6st for initiating signal transmission. the il11/il11ra/il6st complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.
15040	
15041	
15042	may play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.
15043	
15044	
15045	
15046	necessary for elongation and maintenance of stereocilia in the inner and outer hair cells in the organ of corti in the inner ear (by similarity).
15047	
15048	
15049	
15050	
15051	
15052	protein phosphatase (pp1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. involved in regulation of ionic conductances and long-term synaptic plasticity.
15053	splits dipeptides with a prolyl or hydroxyprolyl residue in the c-terminal position. plays an important role in collagen metabolism because the high level of iminoacids in collagen.
15054	catalyzes the covalent attachment of ubiquitin to other proteins. in association with the e3 enzyme bre1 and lge1, it plays a role in transcription regulation by catalyzing the monoubiquitination of lys-123 of histone h2b leading to the trimethylation of histone h3 lys-4 by compass, the localization of the paf1 complex to the chromatin and the silencing of telomeric- associated genes. in association with the e3 enzyme rad18, it catalyzes the monoubiquitination of pol30 lys-164, involved in postreplication repair of uv-damaged dna. the ubc2-rad18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine. in association with the e3 enzyme ubr1, is involved in n-end rule-dependent protein degradation. also involved in sporulation.
15055	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
15056	may be involved in redox reactions associated with the formation of disulfide bonds. may contribute to the quality control of protein folding in the endoplasmic reticulum (by similarity).
15057	
15058	
15059	the crk-i and crk-ii forms differ in their biological activities. crk-ii has less transforming activity than crk-i. crk- ii mediates attachment-induced mapk8 activation, membrane ruffling and cell motility in a rac-dependent manner. involved in phagocytosis of apoptotic cells and cell motility via its interaction with dock1 and dock4.
15060	pore-forming (alpha) subunit of voltage-gated potassium channel. elicits a slowly activating, rectifying current (by similarity). channel properties may be modulated by camp and subunit assembly.
15061	specifically recognizes the xenobiotic response element (xre).
15062	
15063	
15064	binds to f-actin in a calcium-independent manner. has no direct effect on actin depolymerization.
15065	
15066	converts arachidonic acid to 12r- hydroperoxyeicosatetraenoic acid (12r-hpete).
15067	a metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. may also play a role in the metabolism of the vasodilator bradykinin.
15068	
15069	may play a role in rna metabolism.
15070	seems to be involved in p53/tp53 activation and p53/tp53-dependent apoptotic pathways, probably by enhancing acetylation of p53/tp53. component of a msina-like corepressor complex, which probably is involved in deacetylation of nucleosomal histones. ing1l activity seems to be modulated by binding to phosphoinositides (ptdinsps).
15071	
15072	promotes guanine-nucleotide exchange on arf1 and arf5. promotes the activation of arf through replacement of gdp with gtp.
15073	may play a role in chondrocyte differentiation and may also influence cervix development. functions as a repressor with the rat prolactin promoter in vivo.
15074	
15075	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
15076	
15077	does not have a carbonic anhydrase catalytic activity.
15078	catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. mao-a preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-ht), norepinephrine and epinephrine.
15079	histone demethylase that specifically demethylates lys- 36 of histone h3, thereby playing a central role in histone code. preferentially demethylates dimethylated h3 lys-36 residue while it has weak or no activity for mono- and tri-methylted h3 lys-36. demethylation of lys residue generates formaldehyde and succinate. may also recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation.
15080	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
15081	acts as guanine nucleotide exchange factor (gef) for rhoa gtpase. may be involved in activation of the sapk/jnk pathway (by similarity).
15082	
15083	
15084	muscle contraction.
15085	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
15086	thought to stabilize the calcium channel in an inactivated (closed) state.
15087	
15088	
15089	neural cell adhesion molecule.
15090	
15091	may be involved in transcriptional regulation.
15092	receptor for neurturin. mediates the nrtn-induced autophosphorylation and activation of the ret receptor. also able to mediate gdnf signaling through the ret tyrosine kinase receptor.
15093	
15094	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
15095	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
15096	
15097	
15098	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
15099	
15100	
15101	
15102	appears to be involved in the development of the central nervous system specifying regional identities in the development of the forebrain and spinal cord. can recognize, bind and transactivate the np (nearly palindromic) target sequence present in the engrailed gene regulatory region.
15103	
15104	
15105	
15106	
15107	component of the cop9 signalosome complex (csn), a complex involved in various cellular and developmental processes. the csn complex is an essential regulator of the ubiquitin (ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of scf-type e3 ligase complexes, leading to decrease the ubl ligase activity of scf-type complexes such as scf, csa or ddb2. the complex is also involved in phosphorylation of p53/tp53, c-jun/jun, ikappabalpha/nfkbia, itpk1 and icsbp, possibly via its association with ck2 and pkd kinases. csn-dependent phosphorylation of tp53 and jun promotes and protects degradation by the ubl system, respectively. has some glucocorticoid receptor- responsive activity.
15108	
15109	
15110	component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. three proteases; ndl, gd and snk process easter to create active easter. active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the tl receptor in the ventral region of the embryo. promotes heterophilic cellular adhesion. spz c-106 in the hemolymph controls expression of the antifungal peptide drosomycin (drs) by acting as a ligand of tl and inducing an intracellular signaling pathway.
15111	could act as a modulator of transcription.
15112	may play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. seems to demarcate the juxtaparanodal region of the axo-glial junction.
15113	
15114	
15115	acts as an actin bundling protein. may play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
15116	
15117	
15118	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
15119	
15120	controls sodium and chloride ion transport by inhibiting the activity of wnk4, potentially by either phosphorylating the kinase or via an interaction between wnk4 and the autoinhibitory domain of wnk1. wnk4 regulates the activity of the thiazide- sensitive na-cl cotransporter, slc12a3, by phosphorylation. wnk1 may also play a role in actin cytoskeletal reorganization.
15121	
15122	
15123	glycosyltransferase that initiates the elongation of o- linked fucose residues attached to egf-like repeats in the extracellular domain of notch molecules. may be involved in limb formation and in neurogenesis (by similarity).
15124	
15125	required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
15126	may act in the sexual differentiation pathway (by similarity).
15127	
15128	nmda receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine. this protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. it mediates neuronal functions in glutamate neurotransmission. is involved in the cell surface targeting of nmda receptors (by similarity).
15129	receptor for tnfsf13/april and tnfsf13b/tall1/baff/blys that binds both ligands with similar high affinity. mediates calcineurin-dependent activation of nf-at, as well as activation of nf-kappa-b and ap-1. involved in the stimulation of b- and t- cell function and the regulation of humoral immunity.
15130	
15131	
15132	
15133	type i collagen is a member of group i collagen (fibrillar forming collagen).
15134	necessary for spliceosome assembly and for pre-mrna splicing.
15135	
15136	
15137	involved in cytokinesis (potential).
15138	
15139	aminopeptidase with broad substrate specificity to several peptides. involved in proteolytic events essential for cell growth and viability. may act as regulator of neuropeptide activity (by similarity).
15140	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1b gives rise to n-type calcium currents. n-type calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group and are blocked by omega-conotoxin-gvia (omega-ctx-gvia) and by omega-agatoxin- iiia (omega-aga-iiia). they are however insensitive to dihydropyridines (dhp), and omega-agatoxin-iva (omega-aga-iva). calcium channels containing alpha-1b subunit may play a role in directed migration of immature neurons.
15141	
15142	
15143	may be involved in transcriptional regulation.
15144	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes.
15145	
15146	during embryonic development, some isoforms are essential for proper neuronal differentiation and organization. required for cell polarity; maintenance of apicobasal polarity. plays a critical role at septate junctions in cellular growth control during larval development. the presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
15147	positive-acting transcription factor that binds to the immunoglobulin enchancer mue3 motif. it binds also very well to a usf/mltf site. binding of tfe3 to dna induces dna binding.
15148	receptor for grf, coupled to g proteins which activate adenylyl cyclase. stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.
15149	
15150	not known, could be a tyrosine-phosphatase.
15151	could be involved in oogenesis. involved in the regulation of endosome dynamics. implicated in a novel signal transduction pathway, in which isoform 3 and csk are sequentially activated by rhod to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
15152	catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. mao-b preferentially degrades benzylamine and phenylethylamine.
15153	catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. mao-b preferentially degrades benzylamine and phenylethylamine.
15154	acts as a rac1 guanine nucleotide exchange factor (gef).
15155	
15156	
15157	appears to be involved in normal eye anterior-chamber and lens development. transcription factor which may be involved in developmental determination of the mesda.
15158	may be involved in several stages of intracellular trafficking (by similarity).
15159	
15160	
15161	
15162	
15163	
15164	this is the major myelin protein from the central nervous system. it plays an important role in the formation or maintenance of the multilamellar structure of myelin.
15165	binds as a monomer with high affinity to interleukin 13 (il13), but not to il4.
15166	
15167	
15168	
15169	
15170	
15171	
15172	catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in rab proteins with an -xxcc, -xcxc and -ccxx c-terminal, such as rab1a, rab3a and rab5a respectively.
15173	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l.
15174	involved in the retrieval of endoplasmic reticulum membrane proteins from the early golgi compartment (by similarity).
15175	
15176	plays a role as a transcriptional repressor during development. may play a role in the control of cell survival. overexpression of rere recruits bax to the nucleus particularly to pod and triggers caspase-3 activation, leading to cell death.
15177	receptor for netrin required for axon guidance. mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. its association with unc5 proteins may trigger signaling for axon repulsion. it also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. implicated as a tumor suppressor gene.
15178	
15179	interacts strongly with cdk6, weakly with cdk4. inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein rb.
15180	binds specifically to peptidoglycan and is involved in innate immunity. function in intracellular killing of bacteria. the soluble form triggers apoptosis in vitro.
15181	
15182	orphan receptor.
15183	e3 ubiquitin ligase protein that mediates monoubiquitination of lys-119 of histone h2a, thereby playing a central role in histone code and gene regulation. h2a lys-119 ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in x chromosome inactivation of female mammals. may be involved in the initiation of both imprinted and random x inactivation. essential component of the polycomb group (pcg) multiprotein prc1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including hox genes, throughout development. pcg prc1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. acts as the main e3 ubiquitin ligase on histone h2a of the prc1 complex, while ring1 and pcgf4/bmi1 may rather act as a modulator of rnf2/ring2 activity.
15184	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna.
15185	
15186	important for the overall degradation of proteins in lysosomes. essential for adult male and female fertility. may play a role in digestion.
15187	
15188	
15189	
15190	
15191	serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. after activation by auto-catalytic cleavage it cleaves c2 and c4, leading to their activation and to the formation of c3 convertase.
15192	recognizes and binds the palindromic sequence 5@#$%&- ttggcnnnnngccaa-3@#$%& present in viral and cellular promoters and in the origin of replication of adenovirus type 2. these proteins are individually capable of activating transcription and replication.
15193	binds gtp, gdp and gmp. hydrolyzes gtp very efficiently; gdp rather than gmp is the major reaction product.
15194	binds to the sequence 5@#$%&-aacaat-3@#$%& (by similarity).
15195	
15196	receptor for the fc region of complexed or aggregated immunoglobulins gamma. low affinity receptor. involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by b- cells. binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on b-cells (bcr), t-cells (tcr) or via another fc receptor. isoform iib1 fails to mediate endocytosis or phagocytosis. isoform iib2 does not trigger phagocytosis.
15197	may contribute to the transcriptional control of cell growth and differentiation. antagonizes transcriptional activation and cellular transformation by the adenovirus e1a protein. the transcriptional control activity of cell growth requires interaction with igf2r.
15198	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1s gives rise to l-type calcium currents. long-lasting (l-type) calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group. they are blocked by dihydropyridines (dhp), phenylalkylamines, benzothiazepines, and by omega-agatoxin-iiia (omega-aga-iiia). they are however insensitive to omega-conotoxin- gvia (omega-ctx-gvia) and omega-agatoxin-iva (omega-aga-iva). calcium channels containing the alpha-1s subunit play an important role in excitation-contraction coupling in skeletal muscle.
15199	
15200	
15201	may play a role in carrying and orienting carbohydrate, as well as having a more specific role.
15202	
15203	
15204	enhances transcription activation by yy1.
15205	phosphorylates serine- and arginine-rich (sr) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable sr proteins to control rna splicing. phosphorylates serines, threonines and tyrosines (by similarity).
15206	
15207	plays an important role in the de novo pathway of purine nucleotide biosynthesis.
15208	participates in the innate immune response to microbial agents. mediates detection of bacterial flagellins. acts via myd88 and traf6, leading to nf-kappa-b activation, cytokine secretion and the inflammatory response.
15209	induces cartilage and bone formation. may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. plays a role in calcium regulation and bone homeostasis (by similarity).
15210	
15211	
15212	transcriptional regulator with a possible role in patterning of mesoderm during development (by similarity).
15213	
15214	
15215	
15216	
15217	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
15218	
15219	catalyzes the covalent attachment of ubiquitin to other proteins (by similarity).
15220	
15221	
15222	
15223	the association of the dr1/drap1 heterodimer with tbp results in a functional repression of both activated and basal transcription of class ii genes. this interaction precludes the formation of a transcription-competent complex by inhibiting the association of tfiia and/or tfiib with tbp. can bind to dna on its own.
15224	
15225	
15226	required for dna recombination, repair and replication. the activity of rp-a is mediated by single-stranded dna binding and protein interactions.
15227	
15228	
15229	
15230	
15231	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
15232	
15233	may control the transcriptional activity of c-myc. stimulates the activation of e box-dependent transcription by c- myc.
15234	
15235	
15236	part of the complex catalyzing the transfer of n- acetylglucosamine from udp-n-acetylglucosamine to phosphatidylinositol, the first step of gpi biosynthesis.
15237	may have a special functional role during embryogenesis and in adult hematopoietic cells. binds to ubiquitin.
15238	
15239	
15240	
15241	the soluble isoform 2 binds vegf-165 and appears to inhibit its binding to cells. it may also induce apoptosis by sequestering vegf-165. may bind as well various members of the semaphorin family. its expression has an averse effect on blood vessel number and integrity.
15242	orphan receptor; possibly for a chemokine.
15243	microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (by similarity).
15244	muscle contraction.
15245	enhances the androgen receptor transcriptional activity in prostate cancer cells. ligand-independent coactivator of the peroxisome proliferator-activated receptor (ppar) gamma.
15246	enhances the androgen receptor transcriptional activity in prostate cancer cells. ligand-independent coactivator of the peroxisome proliferator-activated receptor (ppar) gamma.
15247	
15248	
15249	catalyzes the first step in the removal of the two c-4 methyl groups of 4,4-dimethylzymosterol.
15250	
15251	
15252	
15253	
15254	
15255	
15256	common junctional plaque protein. the membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. the presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.
15257	potential iron transporter (by similarity).
15258	may have a role in potentiating calcium ion-dependent signaling.
15259	
15260	
15261	
15262	
15263	
15264	
15265	
15266	may neutralize hydrolytic enzymes.
15267	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
15268	
15269	
15270	may be involved in transcriptional regulation.
15271	
15272	
15273	collagen type iv is specific for basement membranes.
15274	may donate electrons to ubiquinone.
15275	thought to play some role in anchoring or stabilizing the nicotinic acetylcholine receptor at synaptic sites. it may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin.
15276	involved in the biogenesis of peroxisomes.
15277	involved in amino acid efflux from the vacuole to the cytoplasm. capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine.
15278	
15279	
15280	may play a role in mrna splicing. may also bind to dna.
15281	
15282	apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated fas (cd95) or tnfr-1 receptors. the resulting aggregate called the death-inducing signaling complex (disc) performs caspase-8 proteolytic activation. active caspase-8 initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
15283	
15284	ensures, in conjunction with srp, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.
15285	has anti-angiogenic properties.
15286	inhibits generation of il-1beta by interacting with caspase-1 and preventing its association with rip2.
15287	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
15288	actin cross-linking/gelling protein (by similarity). involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
15289	actin cross-linking/gelling protein (by similarity). involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
15290	
15291	
15292	
15293	
15294	component of pre-mrna cleavage complex ii and of the trna splicing endonuclease complex.
15295	associates with pyk2 in lymphoid cells. may regulate signaling at sites of adhesion.
15296	
15297	involved in normal and neoplastic cell growth.
15298	
15299	major acute phase reactant. apolipoprotein of the hdl complex.
15300	
15301	
15302	
15303	may be involved in gene regulation within neural lineage cells potentially by direct dna binding or by binding to other transcription factors.
15304	
15305	
15306	involved in oxygen transport from the lung to the various peripheral tissues.
15307	provides the precursors necessary for dna synthesis. catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
15308	glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to g3p and the corresponding alcohols.
15309	
15310	binds specifically to gtp-rho. may serve as a target for rho. it has no enzymatic activity. it may interact with some cytoskeletal component upon rho binding or relay a rho signal to other molecules.
15311	binds specifically to gtp-rho. may serve as a target for rho. it has no enzymatic activity. it may interact with some cytoskeletal component upon rho binding or relay a rho signal to other molecules.
15312	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
15313	involved in the biosynthesis of gangliosides gm2, gd2 and ga2.
15314	
15315	
15316	part of the proton channel of v-atpases (by similarity).
15317	catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
15318	probably involved in synaptic functions in the cns.
15319	
15320	
15321	
15322	regulatory subunit of the cyclin-dependent kinase pair (cdk9/cyclin-t1) complex, also called positive transcription elongation factor b (p-tefb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the ctd (carboxy-terminal domain) of the large subunit of rna polymerase ii (rnap ii). binds also to the transactivation domain of the hiv-1 nuclear transcriptional activator, tat. it is probably the cis-acting transactivation response element (tar) rna-binding cofactor for tat. also serves as an essential cofactor for hiv 2-tat and simian immunodeficiency virus (african mandrill) tat function.
15323	
15324	component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. nua4 may also play a direct role in dna repair when recruited to sites of dna damage.
15325	binds to hiv-1 tar rna located in the long terminal repeat (ltr). acts synergistic with viral tat protein in hiv-1 expression activation. binds preferentially tar and other double- stranded rnas with g+c-rich characteristics.
15326	this protein is one of the chains of the nonenzymatic membrane component (f0) of mitochondrial atpase.
15327	
15328	
15329	
15330	
15331	regulates tat transactivation activity through direct interaction. may be a cellular factor for hiv-1 gene expression and viral replication.
15332	may have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.
15333	
15334	component of the elastin-associated microfibrils.
15335	
15336	f-actin capping proteins bind in a ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. may play a role in the morphogenesis of spermatid.
15337	
15338	class-iv neuronal intermediate filament that is able to self-assemble. it is involved in the morphogenesis of neurons. it may form an independent structural network without the involvement of other neurofilaments or it may cooperate with nf-l to form the filamentous backbone to which nf-m and nf-h attach to form the cross-bridges (by similarity).
15339	
15340	involved in 40s ribosomal subunit biogenesis. it seems to play a role a methylation reaction in pre-rrna processing (by similarity).
15341	
15342	
15343	required for the establishment or function of the nervous system.
15344	plays a role in pre-mrna alternative splicing by regulating spliceosome assembly.
15345	
15346	involved in muscle differentiation (myogenic factor). induces fibroblasts to differentiate into myoblasts. probable sequence specific dna-binding protein.
15347	involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (nk) cells, and platelets.
15348	
15349	
15350	
15351	
15352	
15353	binds specifically to the dna sequence 5@#$%&-aacaat-3@#$%&. activates transcription of col2a1 and agc1 in vitro.
15354	
15355	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
15356	may act as a tumor suppressor.
15357	catalyzes the hydrolysis of atp coupled with the exchange of h(+) and k(+) ions across the plasma membrane. responsible for potassium absorption in various tissues.
15358	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
15359	probably involved in nervous system development and function.
15360	
15361	
15362	
15363	component of the anaphase promoting complex/cyclosome (apc/c), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the g1 phase of the cell cycle.
15364	may act as a gtpase activating protein for rab family protein(s).
15365	
15366	
15367	prevents the aggregation of denatured proteins in cells under severe stress, on which the atp levels decrease markedly. inhibits hspa8/hsc70 atpase and chaperone activities (by similarity).
15368	
15369	
15370	required for cytoplasm to vacuole transport (cvt) vesicles and autophagosomes completion. necessary for the binding of atg18 to atg9. involved in correct atg9 trafficking through the pre-autophagosomal structure and in peroxisome degradation.
15371	inhibitor of serine proteases. the primary target is elastase, but also has a moderate affinity for plasmin and thrombin.
15372	
15373	the smn complex plays an essential role in spliceosomal snrnp assembly in the cytoplasm and is required for pre-mrna splicing in the nucleus.
15374	lipid transport protein in adipocytes. binds both long chain fatty acid and retinoic acid.
15375	
15376	may be a component of one of the vesicle trafficking pathways. may interact functionally with ras2 protein.
15377	
15378	
15379	
15380	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules.
15381	
15382	
15383	
15384	potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. key regulator of adherens junction integrity and differentiation that may be involved in cdh1-mediated adhesion and signaling in epithelial cells.
15385	acts on epoxides (alkene oxides, oxiranes) and arene oxides. plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. also determines steady-state levels of physiological mediators. has low phosphatase activity.
15386	
15387	
15388	implicated in the control of cell fate decisions during development.
15389	involved in embryogenesis and cell differentiation.
15390	may play a role in notch signaling (by similarity).
15391	ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. covalent attachment to its substrates requires prior activation by the e1 complex ube1c- appbp1 and linkage to the e2 enzyme ube2m. attachment of nedd8 to cullins activates their associated e3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
15392	acts as a transcriptional repressor. may be involved in dna damage-inducible cell cycle arrests (checkpoints).
15393	
15394	
15395	
15396	cpsf plays a key role in pre-mrna 3@#$%&-end formation, recognizing the aauaaa signal sequence and interacting with poly(a)polymerase and other factors to bring about cleavage and poly(a) addition (by similarity).
15397	this enzyme is involved in nucleotide metabolism: it produces dump, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dutp so that uracil cannot be incorporated into dna.
15398	
15399	
15400	stimulates smooth muscle contraction in a manner similar to that of bombesin.
15401	receptor for neurotrophin-3 (nt-3). this is a tyrosine- protein kinase receptor. known substrates for the trk receptors are shc1, pi-3 kinase, and plcg1. the different isoforms do not have identical signaling properties.
15402	
15403	hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-coa thioesters. it is an important enzyme in hdl metabolism. hepatic lipase binds heparin.
15404	
15405	
15406	regulation of the apolipoprotein a-i gene transcription. binds to dna site a.
15407	
15408	broad specificity aminopeptidase. plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. may play a critical role in the pathogenesis of cholesterol gallstone disease. may be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the cns. found to cleave antigen peptides bound to major histocompatibility complex class ii molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. is also implicated as a regulator of il-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. also serves as a receptor for human coronavirus serogroup 1 (hcov-229e) in a species-specific manner. mediates as well human cytomegalovirus (hcmv) infection.
15409	participates in dna replication and repair. exhibits a magnesium-dependent atp-dependent dna-helicase activity that unwinds single- and double-stranded dna in a 3@#$%&-5@#$%& direction.
15410	putative odorant receptor.
15411	
15412	
15413	phosphorylates inhibitors of nf-kappa-b thus leading to the dissociation of the inhibitor/nf-kappa-b complex and ultimately the degradation of the inhibitor. may play a special role in the immune response.
15414	may have a role in checkpoint signaling during mitosis (by similarity). enhances tp53-mediated transcriptional activation. binds to sites of dna damage. plays a role in the response to dna damage.
15415	
15416	may participate in a common dna damage response pathway associated with the activation of homologous recombination and double-strand break repair. binds to single and double stranded dna and exhibits dna-dependent atpase activity. underwinds duplex dna and forms helical nucleoprotein filaments.
15417	
15418	
15419	pa2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
15420	
15421	
15422	regulates the differentiation and proliferation of normal cells through the regulation of cell death.
15423	unknown, though mvp is required for normal vault structure. vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport.
15424	high affinity permease for methionine.
15425	
15426	
15427	probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture.
15428	
15429	
15430	has both an apurinic and/or apyrimidinic endonuclease activity and a dna n-glycosylase activity. incises damaged dna at cytosines, thymines and guanines. acts on a damaged strand, 5@#$%& from the damaged site. required for the repair of both oxidative dna damage and spontaneous mutagenic lesions.
15431	
15432	
15433	
15434	
15435	
15436	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
15437	possesses a trypsin-like cleavage specificity (by similarity).
15438	
15439	
15440	part of the nucleoporin complex; required for correct nuclear pore assembly.
15441	probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. may act as a tumor suppressor.
15442	
15443	may be involved in transcriptional regulation.
15444	septins are gtpases involved in cytokinesis that assemble into filaments and form a ring at the cleavage site. may act by recruiting myo1 and hof1, a protein involved in septation, to the site of cleavage. septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
15445	
15446	component of the swr1 complex which mediates the atp- dependent exchange of histone h2a for the h2a variant hzt1 leading to transcriptional regulation of selected genes by chromatin remodeling. involved in chromosome stability.
15447	reversible hydration of carbon dioxide.
15448	the mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, zp1, zp2, zp3, and zp4. zp2 may act as a secondary sperm receptor.
15449	may be involved in transcriptional regulation.
15450	probably involved in the control of the cell cycle. interacts with a yet unknown type of cyclin. can phosphorylate histone h1.
15451	involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. plays a role in the assembly of the exocyst.
15452	involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. plays a role in the assembly of the exocyst.
15453	involved in the transduction of mitogenic signals from the cell membrane to the nucleus.
15454	may initiate a process leading to the deglycation of fructoselysine and of glycated proteins. may play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (dmf), fructoselysine, fructoseglycine, fructose and glycated lysozyme.
15455	essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. gp30 is a potential ligand for this receptor. not activated by egf, tgf- alpha and amphiregulin.
15456	
15457	the major targets of this inhibitor are plasmin and trypsin, but it also inactivates chymotrypsin.
15458	catalyzes the transfer of ptdins and phosphatidylcholine between membranes.
15459	this protein is a subunit of the dihydropyridine (dhp) sensitive calcium channel. plays a role in excitation-contraction coupling. the skeletal muscle dhp-sensitive ca(2+) channel may function only as a multiple subunit complex.
15460	plays a role in the formation of clathrin-coated invaginations and endocytosis.
15461	
15462	muscle contraction.
15463	
15464	band 3 is the major integral glycoprotein of the erythrocyte membrane. band 3 has two functional domains. its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin.
15465	may play a role in antiviral host defense. protects against infection by a neurovirulent strain of sindbis virus. may play a role in autophagy.
15466	chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. augments monocyte anti-tumor activity. has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
15467	probable sugar transporter (by similarity).
15468	
15469	
15470	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
15471	
15472	
15473	
15474	
15475	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity).
15476	circadian regulator that may act as a transcription factor. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition. seems to be the pacemaker component which responds to light and mediates photic entrainment. in the suprachiasmatic nucleus (scn), it behaves like a day-type oscillator, with maximum expression during the light period. oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. there is a 4 hour time delay between per1 and per2 oscillations. the expression rhythms appear to originate from retina. negatively regulates clock-arntl/bmal1-induced transactivation (by similarity).
15477	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
15478	hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. it is important for proliferation during certain stages of b-cell maturation.
15479	component of the polycomb group (pcg) multiprotein prc1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including hox genes, throughout development. pcg prc1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone h2a lys-119, rendering chromatin heritably changed in its expressibility.
15480	
15481	
15482	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
15483	
15484	
15485	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i (by similarity).
15486	
15487	
15488	processively dephosphorylates ser-2 and ser-5 of the heptad repeats ysptsps in the c-terminal domain of the largest rna polymerase ii subunit. this promotes the activity of rna polymerase ii.
15489	plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. binds to the photoreceptor conserved element-i (pce-1/ret 1) in the photoreceptor cell-specific arrestin promoter.
15490	
15491	protein phosphatase that specifically mediates dephosphorylation of ser-473 of akt1, a protein that regulate the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. dephosphorylation of ser- 473 of akt1 triggers apoptosis and suppression of tumor growth. may act as a negative regulator of k-ras signaling in the membrane rafts.
15492	carries 11-cis-retinol and 11-cis-retinaldehyde as endogenous ligands and may be a functional component of the visual cycle.
15493	laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha- 6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-fak and p80, (3) differentiation of keratinocytes.
15494	catalyzes the ferrous insertion into protoporphyrin ix.
15495	
15496	plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
15497	
15498	
15499	
15500	
15501	forms a complex with a krab-domain transcription factor and increases the efficiency of krab-mediated repression. silences transcription through an interaction with hp1 proteins. acts as a corepressor of transcription for the krab zinc finger proteins and as a moderator of the repression activity. may play a role as a coactivator for cebpb and nr3c1 in the transcriptional activation of the alpha-1-acid glycoprotein gene (by similarity).
15502	
15503	the smn complex plays an essential role in spliceosomal snrnp assembly in the cytoplasm and is required for pre-mrna splicing in the nucleus.
15504	
15505	interacts strongly with cdk4 and cdk6.
15506	
15507	
15508	is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. bioactivates 3-methylindole (3mi) by dehydrogenation to the putative electrophile 3-methylene- indolenine.
15509	
15510	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
15511	may mediate activation of casp1 via asc and promote activation of nf-kappa-b via ikk.
15512	interacts with hsp70 and can stimulate its atpase activity. stimulates the association between hsc70 and hip.
15513	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
15514	catalyzes the oxidative decarboxylation of glutaryl-coa to crotonyl-coa and co(2) in the degradative pathway of l-lysine, l-hydroxylysine, and l-tryptophan metabolism. it uses electron transfer flavoprotein as its electron acceptor. the short isoform is inactive.
15515	
15516	orphan receptor. binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5@#$%&-aggtca-3@#$%& and 4-nt spacing (dr-4).
15517	may be involved in processing of pneumocyte surfactant precursors.
15518	
15519	
15520	catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. may also function as a transporter of branched chain alpha-keto acids.
15521	
15522	
15523	suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. regulates cell death by controlling the mitochondrial membrane permeability. appears to function in a feedback loop system with caspases. inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1).
15524	
15525	may be involved in transcriptional regulation.
15526	
15527	catalyzes the transfer of sulfate to position 4 of non- reducing n-acetylgalactosamine (galnac) residues in both n-glycans and o-glycans. required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. only active against terminal galnacbeta1,galnacbeta. not active toward chondroitin.
15528	catalyzes the transfer of sulfate to position 4 of non- reducing n-acetylgalactosamine (galnac) residues in both n-glycans and o-glycans. required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. only active against terminal galnacbeta1,galnacbeta. not active toward chondroitin.
15529	functions as an e3-type small ubiquitin-like modifier (sumo) ligase, stabilizing the interaction between ube2i and the substrate, and as a sumo-tethering factor. plays a crucial role as a transcriptional coregulation in various cellular pathways, including the stat pathway, the p53 pathway, the wnt pathway and the steroid hormone signaling pathway. involved in gene silencing.
15530	dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. enhances the transcriptional activity of tcf1/hnf1a. inhibits epithelial cell migration. mediates colon carcinoma cell survival in mitogen-poor environments.
15531	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
15532	may be involved in transcriptional regulation.
15533	
15534	subunit of the splicing factor sf3a required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex.
15535	
15536	supports the survival of sympathetic neurons in culture. may regulate the development and maintenance of the cns. might control the size of non-neuronal cell population such as haemopoietic cells.
15537	
15538	
15539	
15540	
15541	
15542	may be involved in the death receptor and granzyme b apoptotic pathways. may function as a downstream signal transducer of cell death.
15543	transcription factor.
15544	
15545	required maternally for proper expression of other homeotic genes involved in pattern formation, such as ubx.
15546	
15547	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
15548	
15549	
15550	
15551	part of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends. may function with rpp38 to coordinate the nucleolar targeting and/or assembly of rnase p.
15552	may be involved in transcriptional regulation.
15553	binds dna. interacts with chromatin via matrix attachment regions (mars). likely to participate in nuclear architecture by connecting chromatin with the nuclear matrix and potentially with the nuclear envelope (by similarity).
15554	
15555	6-o-sulfation enzyme which catalyzes the transfer of sulfate from 3@#$%&-phosphoadenosine 5@#$%&-phosphosulfate (paps) to position 6 of the n-sulfoglucosamine residue (glcns) of heparan sulfate.
15556	component of the 39s subunit of mitochondrial ribosome.
15557	
15558	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the p170 subunit of eif3.
15559	may be involved in the control of a single round of dna replication during s phase. binds to chromatin during g1 and detach from it during s phase as if it licenses the chromatin to replicate.
15560	by its binding to cytohesin-1 (pscd1), it modifies activation of arfs by pscd1 and its precise function may be to sequester pscd1 in the cytoplasm.
15561	
15562	may function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment (by similarity).
15563	
15564	interacts with mapk kinases and regulates activation of map kinases. does not display kinase activity (by similarity).
15565	
15566	implicated in neuroendocrine secretory processes. may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. seems to lack intrinsic enzyme activity. may play a role in the regulation of secretory granules via its interaction with sntb2.
15567	
15568	might act as an inhibitor of spontaneous calcium carbonate precipitation. may be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
15569	
15570	may act as a mediator of stress-activated signals.
15571	
15572	serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as tnf-alpha. appears to act upstream of the jun n-terminal pathway.
15573	rna-binding protein. possesses nucleolytic activity against cytotoxic lymphocyte target cells. may be involved in apoptosis.
15574	promotes the exchange of cdc42-bound gdp by gtp. controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. cdc24 may be involved in the initial selection and organization of the budding site.
15575	palmitoyltransferase specific for vac8. palmitoylates vac8 at one or more of its n-terminal cysteine residues, which is required for its proper membrane localization.
15576	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
15577	muscle contraction.
15578	responsible for the reduction of the keto group on the c-3 of sterols.
15579	
15580	mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient.
15581	
15582	
15583	
15584	appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor (by similarity). activates eif2ak2 in absence of double stranded rna (dsrna).
15585	
15586	
15587	ga733 tumor-associated antigen gene family may function as growth factor receptors.
15588	
15589	ph-dependent, voltage-insensitive, background potassium channel protein. rectification direction results from potassium ion concentration on either side of the membrane. acts as an outward rectifier when external potassium concentration is low. when external potassium concentration is high, current is inward.
15590	was first identified based on its probable role in the regulation of pituitary gene transcription. binds to the prolactin gene (prl) promoter and seems to activate transcription. guanine nucleotide exchange factor that activates sara2. required for the formation of copii transport vesicles from the er (by similarity).
15591	
15592	
15593	transporter for alanine, serine, cysteine, and threonine. exhibits sodium dependence.
15594	involved in cytokinesis (potential). can bind to gtp and exert gtpase activity.
15595	
15596	
15597	extremely potent competitive inhibitor of camp-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the camp-induced dissociation of its regulatory chains (by similarity).
15598	acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin g. may prevent elastase-mediated damage to oral and possibly other mucosal tissues.
15599	may be involved in transcriptional regulation.
15600	plays a role in the inducible expression of cytokine genes in t-cells, especially in the induction of the il-2, il-3, il-4, tnf-alpha or gm-csf.
15601	
15602	
15603	required for 60s ribosomal subunit biogenesis.
15604	
15605	
15606	
15607	
15608	
15609	thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. this complex is responsible for the conversion of protein c to the activated protein c (protein ca). once evolved, protein ca scissions the activated cofactors of the coagulation mechanism, factor va and factor viiia, and thereby reduces the amount of thrombin generated.
15610	
15611	
15612	
15613	probably involved in the control of the cell cycle. interacts with cyclins a, b3, d, or e. activity of cdk2 is maximal during s phase and g2.
15614	activates progelatinase a. may also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. cleaves partially fibronectin, but not collagen type i, nor laminin (by similarity).
15615	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
15616	
15617	
15618	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
15619	does not have cyclase activity. plays a role in 40s- ribosomal-subunit biogenesis in the early pre-rrna processing steps at sites a0, a1 and a2 that are required for proper maturation of the 18s rna (by similarity).
15620	
15621	folate-dependent enzyme, that displays both transferase and deaminase activity. serves to channel one-carbon units from formiminoglutamate to the folate pool.
15622	inhibits gtp exchange on ran. forms a ran-gtp-ranbp1 trimeric complex. increase gtp hydrolysis induced by the ran gtpase activating protein rangap1. may act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
15623	
15624	the expression of mif at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. also acts as a phenylpyruvate tautomerase.
15625	
15626	
15627	might normally function as a repressor. ews-fusion- proteins (efps) may play a role in the tumorigenic process. they may disturb gene expression by mimicking, or interfering with the normal function of ctd-polii within the transcription initiation complex. they may also contribute to an aberrant activation of the fusion protein target genes.
15628	probably involved in connections of major cytoskeletal structures to the plasma membrane. high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (by similarity).
15629	
15630	glycosyltransferase which participates in glycosylation of alpha-dystroglycan. may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. may be involved in the addition of a repeated disaccharide unit.
15631	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the subunit p170 of eif- 3.
15632	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the subunit p170 of eif- 3.
15633	
15634	it is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. catalyzes the addition of n-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of n-linked sugar chains. it is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.
15635	transcription factor that binds to and transactivates the tshb promoter. binds to a minimal dna-binding sequence 5@#$%&- [tc][ag][ag]tta[tc][ag]-3@#$%&.
15636	
15637	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
15638	
15639	catalyzes the reversible phosphorolysis of thymidine. the produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
15640	
15641	
15642	the soluble isoform 2 binds vegf-165 and appears to inhibit its binding to cells. it may also induce apoptosis by sequestering vegf-165. may bind as well various members of the semaphorin family. its expression has an averse effect on blood vessel number and integrity.
15643	
15644	
15645	
15646	
15647	this coatomer complex protein, essential for golgi budding and vesicular trafficking, is a selective binding protein (rack) for protein kinase c, epsilon type. it binds to golgi membranes in a gtp-dependent manner (by similarity).
15648	
15649	may mediate accelerated atp-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
15650	
15651	may play a role in regulation of differentiation. in vitro, binds rna, preferentially to both poly(g) and poly(u). overexpressed, blocks differentiation of k562 leukemia cells following treatment with phorbol esters or sodium butyrate without affecting proliferation.
15652	exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in trnas with gu(n) anticodons (trna-asp, -asn, -his and -tyr). after this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (by similarity).
15653	cytokine that can act as a growth factor for activated t and nk cells, enhance the lytic activity of nk/lymphokine- activated killer cells, and stimulate the production of ifn-gamma by resting pbmc.
15654	receptor for c-c type chemokines including scya2/mcp-1, scy3/mip-1-alpha, scya5/rantes and scya7/mcp-3.
15655	inhibitory regulator of the ras-cyclic amp pathway. binds inositol tetrakisphosphate (ip4).
15656	arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
15657	hydrolyzes a variety of proteins.
15658	
15659	induces apoptosis (by similarity).
15660	
15661	intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate.
15662	
15663	
15664	involved in the base excision repair (ber) pathway, by catalyzing the poly(adp-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in dna metabolism. this modification follows dna damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of dna strand breaks. may link the dna damage surveillance network to the mitotic fidelity checkpoint. negatively influences the g1/s cell cycle progression without interfering with centrosome duplication.
15665	
15666	could function as a cell-adhesion protein. acts as a tumor suppressor. required for correct morphogenesis.
15667	proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.
15668	
15669	
15670	
15671	
15672	
15673	the compass (set1c) complex specifically methylates lys- 4 of histone h3, which subsequently plays a role in telomere length maintenance.
15674	probable hormone.
15675	involved in cell wall synthesis where it is required for glycosylation. involved in cell cycle progression through cell- size checkpoint.
15676	
15677	
15678	
15679	
15680	converts big endothelin-1 to endothelin-1 (by similarity).
15681	
15682	
15683	forms critical branches in o-glycans.
15684	component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane (by similarity).
15685	has a negative effect on cell proliferation (by similarity).
15686	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
15687	
15688	involved in the activation cascade of caspases responsible for apoptosis execution. at the onset of apoptosis it proteolytically cleaves poly(adp-ribose) polymerase (parp) at a 216-asp-|-gly-217 bond. cleaves and activates sterol regulatory element binding proteins (srebps) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. cleaves and activates caspase-6, -7 and -9. involved in the cleavage of huntingtin.
15689	
15690	required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. it inhibits the activity of the anaphase promoting complex by sequestering cdc20 until all chromosomes are aligned at the metaphase plate.
15691	probable transcription factor that binds to the dna sequence 5@#$%&-cnaattag-3@#$%&.
15692	
15693	may play a role in germ line formation.
15694	cooperates with ly96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. acts via myd88 and traf6, leading to nf-kappa-b activation, cytokine secretion and the inflammatory response. may also promote apoptosis in response to lipoproteins. recognizes mycoplasmal macrophage-activating lipopeptide-2kd (malp-2), soluble tuberculosis factor (stf), phenol-soluble modulin (psm) and b.burgdorferi outer surface protein a lipoprotein (ospa-l) cooperatively with tlr6.
15695	
15696	visual signal transduction is mediated by a g-protein coupled cascade using cgmp as second messenger. this protein can be activated by cyclic gmp which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
15697	positive effector of bcr-stimulated responses. couples the b-cell antigen receptor (bcr) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase c-gamma-dependent pathway, when phosphorylated on tyr-342 and tyr-346. thus the differential phosphorylation of syk can determine the pathway by which bcr is coupled to the regulation of intracellular calcium ion (by similarity).
15698	furnishes a means for formation of correctly charged gln-trna(gln) through the transamidation of misacylated glu- trna(gln) in the mitochondria. the reaction takes place in the presence of glutamine and atp through an activated gamma-phospho- glu-trna(gln) (potential).
15699	could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.
15700	
15701	
15702	
15703	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
15704	
15705	calcium-dependent, calmodulin-stimulated protein phosphatase. this subunit may have a role in the calmodulin activation of calcineurin. dephosphorylates hspb1 and ssh1.
15706	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
15707	
15708	
15709	involved in mediating interferon-gamma-induced cell death.
15710	
15711	required for protein transport from the er to the golgi complex.
15712	inhibitor of actin polymerization.
15713	receptor for acidic fibroblast growth factor. does not bind to basic fibroblast growth factor. binds fgf19.
15714	
15715	
15716	
15717	
15718	plays a role in autophagy (by similarity). atg12- conjugating enzyme (e2-like enzyme), likely serves as an atg5- recognition molecule.
15719	involved in transport from the endoplasmic reticulum to the golgi apparatus. activated by the guanine nucleotide exchange factor preb. involved in the selection of the protein cargo and the assembly of the copii coat complex.
15720	excises uracil residues from the dna which can arise as a result of misincorporation of dump residues by dna polymerase or due to deamination of cytosine.
15721	acts as a transcription factor. represses transcription of map1a in non-neuronal cells but not in neuronal cells.
15722	
15723	type x collagen is a product of hyperthrophic chondrotocytes and has been localized to presumptive mineralization zones of hyaline cartilage.
15724	type x collagen is a product of hyperthrophic chondrotocytes and has been localized to presumptive mineralization zones of hyaline cartilage.
15725	
15726	
15727	plays a role in tight junctions and adherens junctions.
15728	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
15729	bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. catalyzes the formation of 3- ketoacyl-coa intermediates from both straight-chain and 2-methyl- branched-chain fatty acids.
15730	converts molybdopterin precursor z into molybdopterin. this requires the incorporation of two sulfur atoms into precursor z to generate a dithiolene group.
15731	thought to form a receptor-activated non-selective calcium permeant cation channel. probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or g-protein coupled receptors. activated by diacylglycerol (dag) (by similarity). may also be activated by intracellular calcium store depletion.
15732	
15733	
15734	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
15735	
15736	
15737	stimulates hepatic and intestinal proliferation.
15738	type i collagen is a member of group i collagen (fibrillar forming collagen).
15739	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
15740	
15741	
15742	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel. rho-2 gaba receptor could play a role in retinal neurotransmission.
15743	
15744	
15745	
15746	
15747	
15748	
15749	
15750	histone h3, along with histone h4, plays a central role in nucleosome formation.
15751	may be involved in transcriptional regulation.
15752	histone h3, along with histone h4, plays a central role in nucleosome formation.
15753	putative odorant receptor.
15754	
15755	may be involved in cell-cell interactions and recognition.
15756	
15757	cytokine that binds to ltbr/tnfrsf3. may play a specific role in immune response regulation. provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. isoform 2 is probably non-functional.
15758	mediates interactions of advanced glycosylation end products (age). these are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. receptor for amyloid beta peptide.
15759	probable guanine nucleotide exchange factor. putative effector of ras and/or rap. associates with the gtp-bound form of rap 1a and h-ras in vitro (by similarity).
15760	
15761	
15762	
15763	
15764	the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-coa and co(2). it contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (e1), lipoamide acyltransferase (e2) and lipoamide dehydrogenase (e3).
15765	
15766	specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3@#$%&end of 16s rrna in the 30s particle. its inactivation leads to kasugamycin resistance.
15767	muscle contraction.
15768	
15769	binds to the n-terminal pts2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.
15770	not known; potential regulator of cellular growth.
15771	
15772	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
15773	subunit of the peripheral v1 complex of vacuolar atpase essential for assembly or catalytic function. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
15774	interacts selectively in vitro with the af2-activating domain of the estrogen receptors. association with dna-bound estrogen receptors requires the presence of estradiol.
15775	can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses. may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
15776	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
15777	
15778	acts as a factor that allows the dna to undergo a single round of replication per cell cycle. required for dna replication and cell proliferation. required for s-phase checkpoint activation upon uv-induced damage.
15779	
15780	
15781	
15782	
15783	the intermediate chains seem to help dynein bind to dynactin 150 kda component. may play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
15784	
15785	plays a role in u6 snrnp assembly and function. binds to the 3@#$%& end of u6 snrna, thereby facilitating u4/u6 duplex formation in vitro.
15786	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to sites in the 5@#$%&-flanking sequence of its coding region with various affinities. the consensus sequences of the high and low affinity binding sites are 5@#$%&-taatga[cg]-3@#$%& and 5@#$%&-ctaatttt- 3@#$%&.
15787	hgf is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. it has no detectable protease activity.
15788	hgf is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. it has no detectable protease activity.
15789	involved in the repair of mismatches in dna.
15790	
15791	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
15792	
15793	
15794	
15795	acts as an actin bundling protein (by similarity).
15796	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes and then transfers it to substrates (by similarity).
15797	cleaves dna at double-stranded (dg)n.(dc)n and at single-stranded (dc)n tracts. in addition to deoxyribonuclease activities, also has ribonuclease (rnase) and rnase h activities. capable of generating the rna primers required by dna polymerase gamma to initiate replication of mitochondrial dna (by similarity).
15798	
15799	interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. can also catalyze the reaction of ec 5.4.2.4 (synthase) and ec 3.1.3.13 (phosphatase), but with a reduced activity.
15800	
15801	
15802	
15803	
15804	binds to cntf. the alpha chain provides the receptor specificity.
15805	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
15806	adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (hat), which gives a specific tag for epigenetic transcription activation. plays a central role in myc (c-myc) transcription activation, and also participates in cell transformation by myc. required for p53/tp53-, e2f1- and e2f4-mediated transcription activation. also involved in transcription activation mediated by the adenovirus e1a, a viral oncoprotein that deregulates transcription of key genes. probably acts by linking transcription factors such as e1a, myc or e2f1 to hat complexes such as staga thereby allowing transcription activation. probably not required in the steps following histone acetylation in processes of transcription activation. may be required for the mitotic checkpoint and normal cell cycle progression.
15807	may be involved in transcriptional regulation.
15808	
15809	collagen type iv is specific for basement membranes.
15810	recruits tfiih to the initiation complex and stimulates the rna polymerase ii c-terminal domain kinase and dna-dependent atpase activities of tfiih. both tfiih and tfiie are required for promoter clearance by rna polymerase.
15811	
15812	component of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends. also a component of rnase mrp.
15813	involved in dna repair and mitotic recombination. may play an active role in recombination processes in concert with other members of the rad52 epistasis group.
15814	this protein also expresses aconitase activity.
15815	
15816	this protein also expresses aconitase activity.
15817	component of the large subunit of mitochondrial ribosome.
15818	has an antitumor activity.
15819	
15820	mediates estrogen action in various target organs.
15821	cooperates with tlr4 in the innate immune response to bacterial lipopolysaccharide (lps), and with tlr2 in the response to cell wall components from gram-positive and gram-negative bacteria. enhances tlr4-dependent activation of nf-kappa-b. cells expressing both md2 and tlr4, but not tlr4 alone, respond to lps.
15822	receptor-activated non-selective cation channel involved in detection of sensations such as cold, pain or sounds perception. involved in cold nociception by being activated by cold temperature below 17 degrees celsius, which is close to the noxious cold threshold. not involved in menthol sensation. also involved in pain sensation triggered by mustard oil or capsaicin, the pungent ingredient in chilli peppers, by being activated by these products. also acts as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (thc), the psychoactive component of marijuana. may be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. probably operated by a phosphatidylinositol second messenger system (by similarity).
15823	golgi auto-antigen; probably involved in maintaining cis-golgi structure.
15824	inhibitor of wnt signaling pathway.
15825	two step nadp-dependent conversion of gdp-4-dehydro-6- deoxy-d-mannose to gdp-fucose, involving an epimerase and a reductase reaction.
15826	
15827	has a potent tumor cell motility-stimulating activity.
15828	type i collagen is a member of group i collagen (fibrillar forming collagen).
15829	may function in membrane trafficking. exhibits calcium- dependent phospholipid binding properties (by similarity). seems to have a protein kinase activity.
15830	may play a role in macrophage activation and function.
15831	may be implicated in biomineralization processes. has a function in binding of osteoblasts via the alpha(v)beta(3)- integrin (by similarity).
15832	oxidation of 5,6-dihydroxyindole-2-carboxylic acid (dhica) into indole-5,6-quinone-2-carboxylic acid. may regulate or influence the type of melanin synthesized.
15833	
15834	phosphorylates znf622 and may contribute to its redirection to the nucleus. may be involved in the inhibition of spliceosome assembly during mitosis.
15835	
15836	
15837	
15838	
15839	transcriptional corepressor that binds to a number of transcription factors. inhibits the transcriptional activation mediated by pax5, and by ctnnb1 and tcf family members in wnt signaling. the effects of full-length tle family members may be modulated by association with dominant-negative aes (by similarity).
15840	calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. this protein regulates phospholipase a2 activity. it seems to bind from two to four calcium ions with high affinity.
15841	important for the overall degradation of proteins in lysosomes.
15842	
15843	
15844	produced by macrophages, ifn-alpha have antiviral activities. interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
15845	
15846	a49 is easily dissociated from the rest of pol a (pol i), producing the form a*, which shows impaired transcriptional activity and increased sensitivity to alpha-amanitin. the function of a49 might be linked to the rnase h activity that was found associated with this subunit.
15847	
15848	
15849	
15850	conversion of folates to polyglutamate derivatives. this allows tissues to concentrate folate at higher levels than in plasma.
15851	
15852	may act as a gtpase activating protein for rab family protein(s).
15853	
15854	may serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins (by similarity).
15855	
15856	
15857	involved in the biosynthesis of ganglioside gd1a from gm1b. transfers cmp-neuac with an alpha-2,6-linkage to galnac residue on neuac-alpha-2,3-gal-beta-1,3-galnac of glycoproteins and glycolipids. prefers glycoproteins to glycolipids (by similarity).
15858	
15859	
15860	binds specifically and noncooperatively to the sph and gt-iic @#$%!enhansons@#$%! (5@#$%&-gtggaatgt-3@#$%&) and activates transcription. binds to the m-cat motif (by similarity).
15861	
15862	protein transport. probably involved with ras-related protein rab-3a in synaptic vesicle traffic and/or synaptic vesicle fusion. could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
15863	communication between transverse-tubules and sarcoplasmic reticulum. contraction of skeletal muscle is triggered by release of calcium ions from sr following depolarization of t-tubules (by similarity).
15864	
15865	appears to function in modulating the activity of the immune system during the acute-phase reaction.
15866	involved in the maturation of asn-linked oligosaccharides. trim a single alpha-1,2-linked mannose residue from man(9)glcnac(2) to produce man(8)glcnac(2). the only product is the man(8)glcnac(2) isomer b, the form lacking the middle-arm terminal alpha 1,2-mannose. it may be involved in glycoprotein quality control since it is important to target misfolded glycoproteins for degradation.
15867	
15868	
15869	thrombin, which cleaves bonds after arg and lys, converts fibrinogen to fibrin and activates factors v, vii, viii, xiii, and, in complex with thrombomodulin, protein c.
15870	
15871	may be involved in transcriptional regulation.
15872	sodium-phosphate symporter. active in early growth phase.
15873	
15874	mediator of diverse signals that repress rna polymerase iii transcription. inhibits the de novo assembly of tfiiib onto dna (by similarity).
15875	
15876	
15877	adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. may link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
15878	putative target protein of adp-ribosylation factor.
15879	receptor for members of the ephrin-b family. binds to ephrin-b1 and -b2.
15880	
15881	binds to and inhibits the transcriptional repressor zbtb33, which may lead to activation of target genes of the wnt signaling pathway (by similarity). may associate with and regulate the cell adhesion properties of both c- and e-cadherins. implicated both in cell transformation by src and in ligand- induced receptor signaling through the egf, pdgf, csf-1 and erbb2 receptors.
15882	
15883	
15884	may be involved in the regulation of gene expression by covalent modification of histone proteins. the long isoform is a corepressor of estrogen receptor (er). the short isoform binds to er and sequesters it in the cytoplasm and enhances non-genomic responses of er.
15885	
15886	inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (by similarity).
15887	
15888	pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces.
15889	apo(a) is the main constituent of lipoprotein(a) (lp(a)). it has serine proteinase activity and is able of autoproteolysis. inhibits tissue-type plasminogen activator 1. lp(a) may be a ligand for megalin/gp 330.
15890	
15891	
15892	thrombin, which cleaves bonds after arg and lys, converts fibrinogen to fibrin and activates factors v, vii, viii, xiii, and, in complex with thrombomodulin, protein c.
15893	the elongation of primed dna templates by dna polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (pcna) and activator 1.
15894	
15895	associates with cyclin g and cdk5. seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by hsc70 in non-neuronal cells. expression oscillates slightly during the cell cycle, peaking at g1 (by similarity).
15896	probable motor protein.
15897	neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. may play a role in formation or maintenance of synaptic junctions. may mediate intracellular signaling.
15898	
15899	
15900	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes, such as ube2l3/ubcm4, and then transfers it to substrates.
15901	participates in the detoxification of a plethora of hydrazine and arylamine drugs. catalyzes the n- or o-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
15902	
15903	
15904	
15905	
15906	plays a role in the formation of functional neural circuits from the early stages of synapse formation. has a role in the development of cns functions involved in locomotor activity.
15907	protein transport. probably involved in vesicular traffic (by similarity).
15908	reversible hydration of carbon dioxide.
15909	cell type-specific subunit of tfiid that may function as a gene-selective coactivator in certain cells. tfiid is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
15910	transcriptional repressor.
15911	binds highly specifically to rhoa, rhoc and rac proteins, but does not appear to catalyze guanine nucleotide exchange (by similarity).
15912	synthesis and degradation of fructose 2,6-bisphosphate.
15913	
15914	participates in processes of transmission and amplification of the visual signal. cgmp-pdes are the effector molecules in g-protein-mediated phototransduction in vertebrate rods and cones.
15915	
15916	may play a role in junctional plaques.
15917	this protein promotes the gtp-dependent binding of aminoacyl-trna to the a-site of ribosomes during protein biosynthesis.
15918	
15919	
15920	plays a role as an intracellular lectin in the early secretory pathway. interacts with n-acetyl-d-galactosamine and high-mannose type glycans and may also bind to o-linked glycans. involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (by similarity).
15921	involved in the presentation of foreign antigens to the immune system.
15922	may be involved in transcriptional regulation.
15923	
15924	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
15925	haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes.
15926	
15927	possible cell adhesion receptor. it possesses an intrinsic protein tyrosine phosphatase activity (ptpase). it controls motor axon guidance.
15928	
15929	serine/threonine-protein kinase that acts as a molecular sensor for dna damage. involved in dna nonhomologous end joining (nhej) required for double-strand break (dsb) repair and v(d)j recombination. must be bound to dna to express its catalytic properties. promotes processing of hairpin dna structures in v(d)j recombination by activation of the hairpin endonuclease artemis (dclre1c). the assembly of the dna-pk complex at dna ends is also required for the nhej ligation step. required to protect and align broken ends of dna. may also act as a scaffold protein to aid the localization of dna repair proteins to the site of damage. found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. also involved in modulation of transcription. recognizes the substrate consensus sequence [s/t- q]. phosphorylates ser-139 of histone variant h2ax/h2afx, thereby regulating dna damage response mechanism. phosphorylates dclre1c, c1d, c-abl/abl1, histone h1, hspca, c-jun/jun, p53/tp53, parp1, pou2f1, dhx9, srf, xrcc1, xrcc1, xrcc4, xrcc5, xrcc6, wrn, c- myc/myc and rfa2.
15930	
15931	
15932	nmda receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine. this protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. it mediates neuronal functions in glutamate neurotransmission. is involved in the cell surface targeting of nmda receptors (by similarity).
15933	histones h1 are necessary for the condensation of nucleosome chains into higher order structures.
15934	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. binds to bmp-7, bmp-2 and, less efficiently, bmp-4. binding is weak but enhanced by the presence of type i receptors for bmps.
15935	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
15936	
15937	
15938	
15939	may enhance the cell surface expression of odorant receptors (by similarity).
15940	transcriptional activator that binds to dna sequences containing the consensus 5@#$%&-wgga-3@#$%&. transactivates promoters of the hematopoietic growth factor genes csf2, il3, il8, and of the bovine lysozyme gene. acts synergistically with runx1 to transactivate the il3 promoter. also transactivates the prf1 promoter in natural killer (nk) cells. plays a role in the development and function of nk and nk t-cells and in innate immunity.
15941	
15942	
15943	may enhance the cell surface expression of odorant receptors (by similarity).
15944	not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. antigen recognized on a melanoma by autologous cytolytic t-lymphocytes.
15945	
15946	
15947	may be involved in er/golgi transport and vesicular traffic.
15948	
15949	may be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction.
15950	
15951	binds rna.
15952	
15953	
15954	
15955	
15956	key enzyme in the regulation of glycerol uptake and metabolism.
15957	promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. interaction with flna may allow neuroblast migration from the ventricular zone into the cortical plate. tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (by similarity).
15958	
15959	plays an important role in the organization of the cytoskeleton. binds to and sequesters actin monomers (g actin) and therefore inhibits actin polymerization (by similarity).
15960	
15961	may play a role in organizing the actin cytoskeleton.
15962	
15963	
15964	
15965	
15966	
15967	this enzyme is specific for acyl chain lengths of 4 to 16.
15968	may play a role in axon guidance (by similarity).
15969	
15970	
15971	initiates complex n-linked carbohydrate formation. essential for the conversion of high-mannose to hybrid and complex n-glycans.
15972	can interact with dna and histones and may scavenge nuclear material released from damaged circulating cells. may also function as a calcium-dependent lectin.
15973	
15974	potentiates but cannot initiate fas-induced apoptosis.
15975	
15976	may play a role in regulating interactions between dynein and p150-glued, and the cellular substrates for dynein- mediated motility (such as organelles) (by similarity).
15977	binds specifically to peptidoglycan and is involved in innate immunity. function in intracellular killing of bacteria. the soluble form triggers apoptosis in vitro.
15978	
15979	
15980	peripherin are class-iii neuronal intermediate filament proteins.
15981	
15982	probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as notch receptors and app (beta-amyloid precursor protein). requires the other members of the gamma-secretase complex to have a protease activity. may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. may function in the cytoplasmic partitioning of proteins.
15983	
15984	plays an important role in the eukaryotic peptide chain initiation process (by similarity).
15985	this isozyme may play a role in skeletal mineralization.
15986	
15987	
15988	
15989	
15990	transfers a sulfuryl group to an n-unsubstituted glucosamine linked to a 2-o-sulfo iduronic acid unit on heparan sulfate. unlike 3-ost-1, does not convert nonanticoagulant heparan sulfate to anticoagulant heparan sulfate (by similarity).
15991	expressed on cytokine induced endothelial cells and mediates their binding to leukocytes. the ligand recognized by elam-1 is sialyl-lewis x (alpha(1->3)fucosylated derivatives of polylactosamine that are found at the nonreducing termini of glycolipids).
15992	
15993	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form. this protein may be involved in the regulation of b-cell activation and proliferation.
15994	
15995	
15996	3beta-hsd is a bifunctional enzyme, that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. the 3beta-hsd enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
15997	
15998	
15999	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
16000	forms calcium-sensitive chloride channels. may conduct other physiologically significant anions such as bicarbonate (by similarity).
16001	enhances transcription activation by yy1.
16002	
16003	functions in post-golgi recycling pathways. acts as a recycling carrier to the cell surface.
16004	
16005	
16006	isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
16007	
16008	
16009	
16010	
16011	catalyzes the covalent attachment of ubiquitin to other proteins (by similarity).
16012	
16013	
16014	
16015	
16016	promotes the exchange of ras-bound gdp by gtp.
16017	trafficking protein from a constitutively recycling pathway (by similarity).
16018	controls the classical pathway of complement activation. it binds as a cofactor to c3b/c4b inactivator (c3bina), which then hydrolyzes the complement fragment c4b. it also accelerates the degradation of the c4bc2a complex (c3 convertase) by dissociating the complement fragment c2a. alpha chain binds c4b. it interacts also with anticoagulant protein s and with serum amyloid p component.
16019	
16020	
16021	catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. has little activity towards prostaglandins a1 and e1.
16022	participates in pre-mrna splicing. may play a role in the assembly of the u4/u5/u6 tri-snrnp complex.
16023	
16024	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
16025	required for centriole duplication. inhibition of centriole duplication leading to defects in cytokinesis.
16026	
16027	
16028	
16029	receptor for both octopamine and tyramine, invertebrate neurotransmitters, and neuromodulators. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase. the rank order of potency for agonists is tyramine > octopamine > dopamine > epinephrine > norepinephrine > serotonin > histamine. for antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > cyproheptadine > dihydroergotamine > clonidine > synephrine. tyramine has a functional role in the olfactory system as a neurotransmitter or a neuromodulator.
16030	cartilage matrix protein is a major component of the extracellular matrix of nonarticular cartilage. it binds to collagen.
16031	required for centriole duplication. inhibition of centriole duplication leading to defects in cytokinesis.
16032	
16033	involved in intracellular vesicle trafficking.
16034	collagen type iii occurs in most soft connective tissues along with type i collagen.
16035	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator.
16036	
16037	integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence g-f-p-g-e-r in collagen. integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-v/beta-1 are receptors for fibronectin. alpha-4/beta-1 recognizes one or more domains within the alternatively spliced cs-1 and cs-5 regions of fibronectin. integrin alpha-5/beta-1 is a receptor for fibrinogen. integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. integrin alpha-4/beta-1 is a receptor for vcam1. it recognizes the sequence q-i-d-s in vcam1. integrin alpha-9/beta-1 is a receptor for vcam1, cytotactin and osteopontin. it recognizes the sequence a-e-i-d-g-i-e-l in cytotactin. integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and cspg4. alpha-3/beta-1 may mediate with lgals3 the stimulation by cspg4 of endothelial cells migration. integrin alpha-v/beta-1 is a receptor for vitronectin. beta-1 integrins recognize the sequence r-g-d in a wide array of ligands. isoform beta-1b interferes with isoform beta-1a resulting in a dominant negative effect on cell adhesion and migration (in vitro).
16038	
16039	binds medium- and long-chain acyl-coa esters with very high affinity and may function as an intracellular carrier of acyl-coa esters. it is also able to displace diazepam from the benzodiazepine (bzd) recognition site located on the gaba type a receptor. it is therefore possible that this protein also acts as a neuropeptide to modulate the action of the gaba receptor.
16040	not known. may play a role in regulating the circulating activity of cytokines as it binds to il-1, il-2 and tnf with high affinity.
16041	may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes (by similarity).
16042	
16043	crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. important in mediating the effect of ldl (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-coa reductase and activation of endogenous cellular cholesteryl ester formation.
16044	dna-binding protein that binds to the 5@#$%&-aata[ct]-3@#$%& core sequence. probably acts as a transcription regulator. represses the cytomegalovirus enhancer. overexpression leads to induction of smooth muscle marker genes, suggesting that it may act as a regulator of smooth muscle cell differentiation and proliferation. may be involved in lipid stores.
16045	repair polymerase. involved in base excision repair (ber) responsible for repair of lesions that give rise to abasic (ap) sites in dna. has both dna polymerase and terminal transferase activities. has a 5@#$%&-deoxyribose-5-phosphate lyase (drp lyase) activity.
16046	binds to the lim domain of a wide variety of lim domain- containing transcription factors. may be involved in the development of motor neurons.
16047	may have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. preferentially hydrolyzes inosine 5-prime-monophosphate (imp) and other purine nucleotides.
16048	
16049	
16050	receptor for prolactin-releasing peptide (prrp). implicated in lactation, regulation of food intake and pain-signal processing.
16051	
16052	protease that regulate the availability of igfs by cleaving igf-binding proteins.
16053	metabolizes several precarcinogens, drugs, and solvents to reactive metabolites.
16054	nad-dependent histone deacetylase involved in telomeric silencing. histone deacetylase proteins act via the formation of large multiprotein complexes that are responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. restores silencing at hmr in sir2 mutants when overexpressed. required to repress middle sporulation genes during vegetative growth. acts as a sensor of nad(+) levels and regulator of nad(+) biosynthesis. regulates the gene expression of de novo nad(+) biosynthesis genes.
16055	
16056	may be involved in transcriptional regulation.
16057	
16058	
16059	
16060	
16061	protects the body from potent vasoactive and inflammatory peptides containing c-terminal arg or lys (such as kinins or anaphylatoxins) which are released into the circulation.
16062	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (by similarity). probably encodes a dihydropyridine-insensitive current. vital for survival to adulthood.
16063	
16064	
16065	ras proteins bind gdp/gtp and possess intrinsic gtpase activity.
16066	catalyzes the transfer of sulfate to position 6 of galactose (gal) residues of keratan. has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. the sulfotransferase activity on sialyl lacnac structures is much higher than the corresponding desialylated substrate, and only internal gal residues are sulfated. may function in the sulfation of sialyl n-acetyllactosamine oligosaccharide chains attached to glycoproteins. participates in biosynthesis of selectin ligands. selectin ligands are present in high endothelial cells (hevs) and play a central role in lymphocyte homing at sites of inflammation.
16067	
16068	
16069	
16070	does not act as an allosteric activator of the cholera toxin catalytic subunit. component of a regulated secretory pathway involved in ca(2+)-dependent release of acetylcholine.
16071	
16072	activates the jun n-terminal pathway. required for serum-stimulated cell proliferation and for mitogen and cytokine activation of mapk14 (p38), mapk3 (erk) and mapk8 (jnk1). plays a role in mitogen-stimulated phosphorylation and activation of braf, but does not phosphorylate braf directly. influences microtubule organization during the cell cycle.
16073	probably plays an important role in neuronal membrane skeleton.
16074	mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. less sensitive than slc29a1 to inhibition by nitrobenzylthioinosine (nbmpr), dipyridamole, dilazep and draflazine.
16075	involved in redox regulation of the cell. can reduce h(2)o(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
16076	
16077	one of the multiple factors required for polyadenylation and 3@#$%&-end cleavage of mammalian pre-mrnas.
16078	the long isoform may play a role in neural and glial cell adhesion in the developing embryo. the short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. vital for embryonic development. essential for septate junctions. septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. required for the blood-brain barrier formation.
16079	may be involved in several stages of intracellular trafficking (by similarity).
16080	apoptotic suppressor. the bir motifs region interacts with tnf receptor associated factors 1 and 2 (traf1 and traf2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (tnfr2).
16081	binds to dna sequences containing the consensus nucleotide core sequence ggaa.
16082	l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists.
16083	probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. also required for the transfer of beta-barrel precursors from the tom complex to the sorting and assembly machinery (sam complex) of the outer membrane. acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (by similarity).
16084	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. this receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. it is a cation-specific, but otherwise relatively nonselective, ion channel.
16085	
16086	the cd3 complex mediates signal transduction.
16087	tetrapolymerization of the monopyrrole pbg into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
16088	catalyzes a dehydrogenation to introduce c5-6 double bond into lathosterol.
16089	may play a role in tumorigenesis as a tumor suppressor. altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis.
16090	
16091	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
16092	appears to play a role in the switch from cap-dependent to ires-mediated translation during mitosis, apoptosis and viral infection. cleaved by some caspases and viral proteases.
16093	
16094	
16095	
16096	
16097	
16098	
16099	may regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. might be involved in the regulation of general functions of integrins.
16100	
16101	
16102	
16103	
16104	may play a role in transporting nutrient from the gut lumen across the gutlining epithelial cell layer.
16105	
16106	
16107	
16108	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. in retina, myosin viia might play a role in trafficking of ribbon- synaptic vesicle complexes and renewal of the outer photoreceptors disks. in inner ear, it might maintain the rigidity of stereocilia during the dynamic movements of the bundle. involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (by similarity).
16109	
16110	
16111	promotes the exchange of gdp by gtp. together with leukocyte antigen-related (lar) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.
16112	golgi auto-antigen; probably involved in maintaining golgi structure.
16113	
16114	
16115	probably involved in the control of the cell cycle. interacts with cyclins a, b3, d, or e. activity of cdk2 is maximal during s phase and g2.
16116	
16117	
16118	seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit kpnb1. acting autonomously, is thought to serve itself as receptor for nuclear localization signals (nls) and to promote translocation of import substrates through the nuclear pore complex (npc) by an energy requiring, ran-dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. in vitro mediates the nuclear import of srp19.
16119	
16120	methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
16121	
16122	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression.
16123	orphan receptor. it may be an important receptor for signals controlling growth and differenciation of specific embryonic tissues (by similarity).
16124	acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
16125	cysteine protease required for autophagy, which cleaves the c-terminal part of either map1lc3, gabarapl2 or gabarap, allowing the liberation of form i. a subpopulation of form i is subsequently converted to a smaller form (form ii). form ii, with a revealed c-terminal glycine, is considered to be the phosphatidylethanolamine (pe)-conjugated form, and has the capacity for the binding to autophagosomes.
16126	
16127	
16128	receptor that may play a role in the perception of bitterness and is gustducin-linked. may play a role in sensing the chemical composition of the gastrointestinal content. the activity of this receptor may stimulate alpha gustducin, mediate plc-beta-2 activation and lead to the gating of trpm5 (by similarity).
16129	receptor that may play a role in the perception of bitterness and is gustducin-linked. may play a role in sensing the chemical composition of the gastrointestinal content. the activity of this receptor may stimulate alpha gustducin, mediate plc-beta-2 activation and lead to the gating of trpm5 (by similarity).
16130	
16131	orphan receptor.
16132	
16133	required for protein transport from the er to the golgi complex.
16134	probable e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. non essential.
16135	
16136	
16137	plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. the tripartite complex composed of lin7 (lin7a, lin7b or lin7c), cask and apba1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. ensures the proper localization of grin2b (subunit 2b of the nmda receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. required to localize kir2 channels, gaba transporter (slc6a12) and egfr/erbb1, erbb2, erbb3 and erbb4 to the basolateral membrane of epithelial cells.
16138	
16139	removes the amino-terminal methionine from nascent proteins.
16140	may function as signal-transmitting receptor.
16141	orphan receptor.
16142	
16143	binds to the sequence element 5@#$%&-aacgaccgaccttgag-3@#$%& of the enhancer ii of hepatitis b virus genes, a critical cis-element of their expression and regulation. may be responsable for the liver-specific activity of enhancer ii, probably in combination with other hepatocyte transcription factors. key regulator of cholesterol 7-alpha-hydroxylase gene (cyp7a) expression in liver. may also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
16144	
16145	
16146	
16147	
16148	cytokine that binds to tnfrsf11b/opg and to tnfrsf11a/rank. osteoclast differentiation and activation factor. augments the ability of dendritic cells to stimulate naive t-cell proliferation. may be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
16149	
16150	may function as a transcription factor.
16151	component of the proteolytic cascade acting downstream of the 26s proteasome in the ubiquitin-proteasome pathway. may be able to complement the 26s proteasome function to some extent under conditions in which the latter is inhibited (by similarity).
16152	receptor for the fl cytokine. has a tyrosine-protein kinase activity.
16153	
16154	ubiquitin-like modifier protein which binds to a number of as yet unidentified target proteins.
16155	part of a multiprotein post-splicing mrnp complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. binds spliced mrna upstream of exon-exon junctions.
16156	
16157	
16158	may play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. may modulate sc6a1/gat1-mediated gaba uptake by stabilizing the transporter. required for localization of vil2 to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (by similarity).
16159	
16160	polymerase that creates the 3@#$%& poly(a) tail of mrna@#$%&s. also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. may acquire specificity through interaction with a cleavage and polyadenylation specificity factor (cpsf) at its c-terminus.
16161	
16162	transcriptional activator binding to the e-box 1 core sequence of the e-cadherin promoter gene; the core-binding sequence is 5@#$%&caggtg-3@#$%&. capable of reversing ctbp1-mediated transcription repression. also participates in the regulation of alternative pre-mrna splicing. associates to spliced mrna within 60 nt upstream of the 5@#$%& splice sites. involved in the establishment and maintenance of epithelia cell-cell adhesion. potential tumor suppressor for renal cell carcinoma.
16163	required for pseudopod elongation in transformed cells.
16164	
16165	sodium-independent exchanger of cationic and large neutral amino acids.
16166	
16167	guanine nucleotide exchange factor that potentially links pathways that signal through rac1, rhoa and cdc42. catalyzes guanine nucleotide exchange on rhoa and cdc42 and interacts specifically with the gtp-bound form of rac1, suggesting that it functions as an effector of rac1. may also participate in axonal transport in the brain. becomes activated and highly tumorigenic by truncation of the n-terminus (by similarity).
16168	may be involved in transcriptional regulation.
16169	
16170	
16171	
16172	
16173	
16174	
16175	
16176	
16177	
16178	component of the cleavage and polyadenylation specificity factor (cpsf) complex that play a key role in pre-mrna 3@#$%&-end formation, recognizing the aauaaa signal sequence and interacting with poly(a) polymerase and other factors to bring about cleavage and poly(a) addition.
16179	
16180	electrically silent transporter system. mediates sodium and chloride reabsorption. plays a vital role in the regulation of ionic balance and cell volume.
16181	
16182	
16183	
16184	
16185	
16186	
16187	positive effector of bcr-stimulated responses. couples the b-cell antigen receptor (bcr) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase c-gamma-dependent pathway, when phosphorylated on tyr-342 and tyr-346. thus the differential phosphorylation of syk can determine the pathway by which bcr is coupled to the regulation of intracellular calcium ion.
16188	recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (by similarity).
16189	it is involved in repression by a1-alpha2 and alpha2 and in other systems as a general repressor of transcription. this protein has no obvious dna-binding domains. it might not interact directly with dna but with dna-bound proteins.
16190	
16191	binds preferentially single-stranded dna and unwinds double stranded dna.
16192	binds preferentially single-stranded dna and unwinds double stranded dna.
16193	
16194	may be involved in transcriptional regulation.
16195	potent inhibitor of cell death. isoform bcl-x(l) anti- apoptotic activity is inhibited by association with siva isoform 1. inhibits activation of caspases (by similarity). appears to regulate cell death by blocking the voltage-dependent anion channnel (vdac) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. the bcl-x(s) isoform promotes apoptosis.
16196	
16197	transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (upr). acts during endoplasmic reticulum stress (er) by activating unfolded protein response (upr) target genes via direct binding to the upr element (upre). binds dna preferably to the cre-like element 5@#$%&- gatgacgtg[tg]n(3)[at]t-3@#$%&, and also to some tpa response elements (tre). binds to the hla dr-alpha promoter. binds to the tax- responsive element (tre) of htlv-i.
16198	
16199	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
16200	desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
16201	
16202	
16203	key enzyme in the regulation of glycerol uptake and metabolism.
16204	key enzyme in the regulation of glycerol uptake and metabolism.
16205	
16206	collagen type ii is specific for cartilaginous tissues. it is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
16207	vinexin alpha isoform promotes up-regulation of actin stress fiber formation. vinexin beta isoform plays a role in cell spreading and enhances the activation of jnk/sapk in response to egf stimulation by using its third sh3 domain.
16208	
16209	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
16210	involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. may play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. low-affinity receptor for agouti (by similarity). has a critical role in normal myelination in the central nervous system (by similarity).
16211	
16212	may play a role in protein processing in limb, cardiac and reproductive system development.
16213	
16214	
16215	
16216	
16217	
16218	
16219	
16220	
16221	
16222	may be involved in transcriptional regulation. coactivator for steroid receptors.
16223	
16224	
16225	
16226	
16227	
16228	
16229	
16230	
16231	
16232	
16233	
16234	this protein promotes the gtp-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome.
16235	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
16236	
16237	
16238	
16239	binds to splice sites in pre-mrna and regulates splice site selection. binds and stabilizes cytoplasmic mrna. contributes to the regulation of translation by modulating the interaction between the mrna and eukaryotic initiation factors (by similarity). binds to promoters that contain a y-box (5@#$%&- ctgattggccaa-3@#$%&), such as hla class ii genes. regulates the transcription of numerous genes. promotes separation of dna strands that contain mismatches or are modified by cisplatin. has endonucleolytic activity and can introduce nicks or breaks into double-stranded dna (in vitro). may play a role in dna repair.
16240	required for 60s ribosomal subunit biogenesis.
16241	
16242	
16243	
16244	
16245	
16246	
16247	
16248	
16249	
16250	
16251	
16252	
16253	
16254	
16255	transcriptional activator that binds to the upstream enhancer region (ccac box) of myoglobin gene. has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli.
16256	
16257	tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. it seems to be required for cartilage and growth plate development.
16258	
16259	
16260	
16261	
16262	
16263	
16264	
16265	
16266	
16267	
16268	the s.cerevisiae ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-amp.
16269	
16270	
16271	transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. potential role in g2/m cell cycle regulation (by similarity).
16272	may play a key role in signal transduction and growth control.
16273	ubiquitin ligase protein which is a component of the n- end rule pathway. recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the n-end rule, leading to their ubiquitination and subsequent degradation.
16274	
16275	
16276	
16277	can act as repulsive axon guidance cues. may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.
16278	
16279	transcriptional inhibitor that binds to dna sequence 5@#$%&- cacct-3@#$%& in different promoters (by similarity).
16280	
16281	associates with cyclin g and cdk5. seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by hsc70 in non-neuronal cells. expression oscillates slightly during the cell cycle, peaking at g1 (by similarity).
16282	
16283	
16284	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
16285	
16286	
16287	general activator of rna polymerase which utilizes different tfiiib complexes at structurally distinct promoters. the isoform 1 is involved in the transcription of trna, adenovirus va1, 7sl and 5s rna. isoform 2 is required for transcription of the u6 promoter.
16288	
16289	
16290	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
16291	it may serve as a negative regulator of t-cell receptor (tcr) signaling via inhibition of calcineurin. interacts with and inhibits calcineurin-mediated signal transduction. cabin 1 is specific for the activated form of calcineurin, their interaction is dependent on both pkc and calcium signals.
16292	probably acts as a regulator of other genes. forms a complex with adenovirus e1a and with sv40 large t antigen. acts as a tumor suppressor. may bind and modulate functionally certain cellular proteins with which t and e1a compete for pocket binding. potent inhibitor of e2f-mediated trans-activation. recruits and targets histone methyltransferase suv39h1 leading to epigenetic transcriptional repression. inhibits the intrinsic kinase activity of taf1.
16293	
16294	
16295	catalyzes the 6-electron oxidation of protoporphyrinogen ix to form protoporphyrin ix.
16296	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. this protein may mediate formation of the complex between cytochromes c and c1.
16297	
16298	
16299	
16300	
16301	
16302	
16303	sodium-phosphate symporter. active in early growth phase.
16304	single-stranded nucleic acid binding protein that binds preferentially to oligo dc.
16305	
16306	catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.
16307	transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney (by similarity).
16308	
16309	
16310	
16311	
16312	the cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
16313	catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (ipp) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (dmapp).
16314	
16315	receptor for all-trans- and 11-cis-retinal. binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.
16316	corepressor targeting diverse transcription regulators (by similarity).
16317	displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols.
16318	
16319	causes the formation of thin, actin-rich surface projections called filopodia. functions cooperatively with cdc42 and rac to generate additional structures, increasing the diversity of actin-based morphology.
16320	causes the formation of thin, actin-rich surface projections called filopodia. functions cooperatively with cdc42 and rac to generate additional structures, increasing the diversity of actin-based morphology.
16321	
16322	
16323	desmuslin is a type-vi intermediate filament which may function as a mechanical support to the muscle fibers by making a linkage between the extracellular matrix via the dystrophin- associated protein complex (dapc) and the z-disk.
16324	component of the cornified envelope of keratinocytes. may link the cornified envelope to desmosomes and intermediate filaments.
16325	
16326	
16327	may play a role in the proliferation or differentiation of keratinocytes.
16328	
16329	
16330	acts as a negative regulator of entry into mitosis (g2 to m transition) by two mechanisms. catalyzes the inhibitory phosphorylation of the cdc2 kinase specifically when the latter is complexed to cyclins. phosphorylation of cdc2 occurs predominantly on thr-14 (and maybe also to a lesser degree on tyr-15). may also inhibit mitotic entry by cytoplasmic retention of cdc2/ccnb1 complexes.
16331	may be involved in n-glycosylation through its association with n-oligosaccharyl transferase.
16332	
16333	dna- and rna binding protein, involved in several nuclear processes. essential pre-mrna splicing factor required early in spliceosome formation and for splicing catalytic step ii, probably as an heteromer with nono. binds to pre-mrna in spliceosome c complex, and specifically binds to intronic polypyrimidine tracts. interacts with u5 snrna, probably by binding to a purine-rich sequence located on the 3@#$%& side of u5 snrna stem 1b. may be involved in a pre-mrna coupled splicing and polyadenylation process as component of a snrnp-free complex with snrpa/u1a. the sfpq-nono heteromer associated with matr3 may play a role in nuclear retention of defective rnas. sfpq may be involved in homologous dna pairing; in vitro, promotes the invasion of ssdna between a duplex dna and produces a d-loop formation. the sfpq-nono heteromer may be involved in dna unwinding by modulating the function of topoisomerase i/top1; in vitro, stimulates dissociation of top1 from dna after cleavage and enhances its jumping between separate dna helices. the sfpq-nono heteromer may be involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination and may stabilize paired dna ends; in vitro, the complex strongly stimulates dna end joining, binds directly to the dna substrates and cooperates with the ku70/g22p1-ku80/xrcc5 (ku) dimer to establish a functional preligation complex. sfpq is involved in transcriptional regulation. transcriptional repression is probably mediated by an interaction of sfpq with sin3a and subsequent recruitment of histone deacetylases (hdacs). the sfpq-nono/sf-1 complex binds to the cyp17 promoter and regulates basal and camp- dependent transcriptional avtivity. sfpq isoform long binds to the dna binding domains (dbd) of nuclear hormone receptors, like rxra and probably thra, and acts as transcriptional corepressor in absence of hormone ligands. binds the dna sequence 5@#$%&-ctgagtc-3@#$%& in the insulin-like growth factor response element (igfre) and inhibits igf-i-stimulated transcriptional activity.
16334	
16335	
16336	
16337	
16338	
16339	may play a role in granule-membrane fusion and degranulation.
16340	potential tumor suppressor. acts as a phosphoinositide 3-phosphatase by regulating ptdins(3,4,5)p3 levels. involved in regulation of the akt1 signaling pathway. the unphosphorylated form cooperates with aip1 to suppress akt1 activation.
16341	
16342	histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a central role in histone code. preferentially demethylates mono- and dimethylated h3 lys-9 residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated h3 lys-9. demethylation of lys residue generates formaldehyde and succinate. involved in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes, resulting in h3 lys-9 demethylation and transcriptional activation.
16343	
16344	
16345	
16346	
16347	controls phosphatidylcholine synthesis.
16348	functions as a calcium permeable cation channel. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis.
16349	induces disassembly of actin filaments in conjunction with adf/cofilin family proteins (by similarity).
16350	
16351	racemization of 2-methyl-branched fatty acid coa esters. responsible for the conversion of pristanoyl-coa and c27-bile acyl-coas to their (s)-stereoisomers.
16352	
16353	
16354	
16355	
16356	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
16357	
16358	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
16359	
16360	
16361	participates in the folding of proteins containing disulfide bonds (by similarity).
16362	role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. may have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (by similarity).
16363	
16364	
16365	may be involved in several stages of intracellular trafficking. could play an important role in the regulation of glucose transport by insulin. may act as a downstream effector of rhoq/tc10 in the regulation of insulin-stimulated glucose transport (by similarity).
16366	
16367	acts as a receptor for sonic hedgehog (shh), indian hedgehog (ihh) and desert hedgehog (dhh). associates with the smoothened protein (smo) to transduce the hedgehog@#$%&s proteins signal. seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
16368	
16369	
16370	
16371	during embryonic development, some isoforms are essential for proper neuronal differentiation and organization. required for cell polarity; maintenance of apicobasal polarity. plays a critical role at septate junctions in cellular growth control during larval development. the presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
16372	the association of the dr1/drap1 heterodimer with tbp results in a functional repression of both activated and basal transcription of class ii genes. this interaction precludes the formation of a transcription-competent complex by inhibiting the association of tfiia and/or tfiib with tbp. can bind to dna on its own.
16373	the pr65 subunit of protein phosphatase 2a serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory b subunit.
16374	receptor for il-10; binds il-10 with a high affinity.
16375	cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the peyer patches and the intestinal lamina propria. it can bind both integrin alpha-4/beta-7 and l-selectin, regulating both the passage and retention of leukocytes. isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of l- selectin binding.
16376	
16377	may play a role in vesicular protein sorting, similar to the yeast retromer proteins (by similarity).
16378	transcriptionally controlled transcription factor. binds to dna sites required for the transcription of alpha 1- antitrypsin, apolipoprotein ciii, transthyretin genes and hnf1- alpha. may be essential for development of the liver, kidney and intestine.
16379	
16380	
16381	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein.
16382	may function as an antagonist of fibroblast growth factor (fgf) pathways and may negatively modulate respiratory organogenesis.
16383	
16384	
16385	
16386	
16387	
16388	
16389	
16390	
16391	
16392	
16393	hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
16394	
16395	neuroleukin is a neurotrophic factor for spinal and sensory neurons.
16396	
16397	
16398	
16399	transcription factor that seems to function synergistically with the pou domain protein tst-1/oct6/scip. could confer cell specificity to the function of other transcription factors in developing and mature glia (by similarity).
16400	interacts with slp-76 to regulate nf-at activation. binds to tyrosine-phosphorylated shc.
16401	
16402	
16403	
16404	
16405	
16406	
16407	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
16408	promotes guanine-nucleotide exchange on arf1 and arf3. promotes the activation of arf1/arf3 through replacement of gdp with gtp.
16409	membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. binds to calmodulin.
16410	
16411	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
16412	
16413	
16414	
16415	
16416	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
16417	necessary for centrosome duplication.
16418	
16419	
16420	
16421	
16422	
16423	
16424	
16425	not yet known, orphan transporter.
16426	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
16427	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
16428	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
16429	
16430	
16431	
16432	involved in the presentation of foreign antigens to the immune system.
16433	the substrate transported is not yet known. induces mitochondrial depolarization.
16434	
16435	
16436	
16437	
16438	
16439	
16440	
16441	
16442	
16443	
16444	
16445	
16446	
16447	
16448	
16449	
16450	
16451	
16452	
16453	
16454	
16455	
16456	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
16457	
16458	catalyzes the cyclization of (s)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
16459	
16460	e3 ubiquitin ligase protein that is required for specification of r7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of tramtrack (ttk). e3 ubiquitin ligases accept ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cells in the eye, leading to the differentiation of cells into neurons. also involved in external sensory organ development.
16461	
16462	
16463	
16464	
16465	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
16466	igf-1 leads to the activation of akt3, which may play a role in regulating cell survival. capable of phosphorylating several known proteins. truncated isoform 2/pkb gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
16467	
16468	associated with snrnp u1, u2, u4/u6 and u5.
16469	
16470	
16471	cytochalasin b-sensitive carrier. seems to function primarily as a fructose transporter.
16472	adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. may regulate the formation of clathrin-coated vesicles. isoform 1 could be involved in brain-specific synaptic vesicle recycling.
16473	synthesis and degradation of fructose 2,6-bisphosphate.
16474	the heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.
16475	
16476	
16477	
16478	related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. it has intrinsic gtpase and atpase activities. may play an important role in transcription catalyzed by rna polymerase i (by similarity).
16479	isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
16480	
16481	
16482	
16483	
16484	
16485	not known.
16486	
16487	
16488	
16489	in the nervous system, could hydrolyze atp and other nucleotides to regulate purinergic neurotransmission. hydrolyzes adp only to a marginal extent.
16490	
16491	
16492	
16493	
16494	
16495	
16496	
16497	required for proper activation of rho gtpases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via nmda receptors. non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (paf) by removing the acetyl group at the sn-2 position (by similarity). positively regulates the activity of the minus-end directed microtubule motor protein dynein. may enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. required for several dynein- and microtubule-dependent processes such as the maintenace of golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. during nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. may also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.
16498	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
16499	
16500	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
16501	may function as a transcription factor. seems to repress transcription.
16502	
16503	component of the adaptor complexes which link clathrin to receptors in coated vesicles. clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. ap2s1/ap17 is a subunit of the plasma membrane adaptor. the complex binds polyphosphoinositides.
16504	
16505	
16506	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
16507	
16508	involved in the presentation of foreign antigens to the immune system.
16509	
16510	
16511	
16512	
16513	seems to mediate adhesion by cell surface integrin binding. may serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment.
16514	
16515	
16516	
16517	may have a special functional role during embryogenesis and in adult hematopoietic cells. binds to ubiquitin.
16518	may play a role in the initial growth and guidance of axons. may be involved in cell adhesion.
16519	catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
16520	catalyzes the initial reaction in o-linked oligosaccharide biosynthesis, the transfer of an n-acetyl-d- galactosamine residue to a serine or threonine residue on the protein receptor. has activity toward hiv envelope glycoprotein gp120, ea2, muc2 and muc5. probably glycosylates fibronectin in vivo. plays a central role in phosphate homeostasis.
16521	
16522	
16523	
16524	
16525	
16526	may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of e4tf1. in tumor cell lines, may induce apoptosis.
16527	
16528	part of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends.
16529	may play a structural role at sites of cell adhesion in maintaining cell shape and motility. in addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. may be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
16530	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
16531	
16532	
16533	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase c. it could help neuronal cells to establish short- term memory.
16534	cam-kinase ii (camk2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.
16535	
16536	catalyzes the cleavage of l-kynurenine (l-kyn) and l-3- hydroxykynurenine (l-3ohkyn) into anthranilic (aa) and 3- hydroxyanthranilic acids (3-ohaa), respectively. has a preference for the l-3-hydroxy form. also has cysteine-conjugate-beta-lyase activity (by similarity).
16537	
16538	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
16539	transcriptional activator that binds to the upstream enhancer region (ccac box) of myoglobin gene. has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli.
16540	
16541	component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level.
16542	component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level.
16543	acts as a receptor for sonic hedgehog (shh), indian hedgehog (ihh) and desert hedgehog (dhh). associates with the smoothened protein (smo) to transduce the hedgehog@#$%&s proteins signal. seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
16544	
16545	
16546	
16547	
16548	
16549	thiol protease. has dipeptidylpeptidase activity. can act as both an exopeptidase and endopeptidase. activates serine proteases such as elastase, cathepsin g and granzymes a and b. can also activate neuraminidase and factor xiii.
16550	apoptotic suppressor. the bir motifs region interacts with tnf receptor associated factors 1 and 2 (traf1 and traf2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (tnfr2).
16551	
16552	
16553	orphan receptor.
16554	
16555	
16556	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. receptor for anti-muellerian hormone.
16557	
16558	
16559	
16560	
16561	
16562	
16563	endopeptidase that degrades various components of the extracellular matrix. may activate progelatinase a.
16564	
16565	plays a role in the formation of functional neural circuits from the early stages of synapse formation. has a role in the development of cns functions involved in locomotor activity.
16566	
16567	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
16568	
16569	
16570	transcription factor that binds to the interleukin-6 (il-6)-responsive elements identified in the promoters of various acute-phase protein genes.
16571	essential role in pre-mrna splicing.
16572	binds ldl, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. in order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
16573	
16574	
16575	receptor on natural killer (nk) cells for hla-c alleles. does not inhibit the activity of nk cells.
16576	may be involved in several stages of intracellular trafficking (by similarity).
16577	may be involved in the nuclear localization pathway of mcm3.
16578	
16579	
16580	
16581	
16582	
16583	
16584	
16585	
16586	dorsalizing factor. key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing tgf-beta family bone morphogenetic proteins (bmps) and sequestering them in latent complexes (by similarity).
16587	
16588	
16589	
16590	
16591	
16592	functions in nuclear protein import as an adapter protein for nuclear receptor kpnb1. binds specifically and directly to substrates containing either a simple or bipartite nls motif. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. in vitro, mediates the nuclear import of human cytomegalovirus ul84 by recognizing a nonclassical nls. in vitro, mediates the nuclear import of human cytomegalovirus ul84 by recognizing a nonclassical nls.
16593	
16594	
16595	terminates the action of gaba by its high affinity sodium-dependent reuptake into presynaptic terminals (by similarity).
16596	
16597	potential tumor suppressor. acts as a phosphoinositide 3-phosphatase by regulating ptdins(3,4,5)p3 levels. involved in regulation of the akt1 signaling pathway. the unphosphorylated form cooperates with aip1 to suppress akt1 activation.
16598	
16599	
16600	
16601	
16602	
16603	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex. necessary for h(+) conduction (by similarity).
16604	
16605	receptor for the mcp-1, mcp-3 and mcp-4 chemokines. transduces a signal by increasing the intracellular calcium ions level. alternative coreceptor with cd4 for hiv-1 infection.
16606	
16607	
16608	
16609	
16610	
16611	
16612	
16613	
16614	
16615	
16616	
16617	
16618	
16619	
16620	
16621	inhibits endothelial cell migartion (in vitro). may be involved in g protein-linked signaling (by similarity).
16622	
16623	
16624	
16625	
16626	implicated in the early stage of ectopic ossification.
16627	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
16628	
16629	
16630	
16631	
16632	
16633	transcriptional repressor.
16634	
16635	
16636	
16637	
16638	
16639	
16640	
16641	muscle contraction.
16642	probable atp-binding rna helicase.
16643	
16644	
16645	
16646	
16647	anticoagulant plasma protein; it is a cofactor to activated protein c in the degradation of coagulation factors va and viiia. it helps to prevent coagulation and stimulating fibrinolysis.
16648	
16649	
16650	required for normal golgi structure and for protein transport from the endoplasmic reticulum (er) through the golgi apparatus to the cell surface.
16651	overproduction suppresses the slow growth phenotype of cpr7 mutant cells.
16652	probably important in cardiac repolarization. associates with kcne1 (mink) to form the i(ks) cardiac potassium current. elicits a rapidly activating, potassium-selective outward current. muscarinic agonist oxotremorine-m strongly suppresses kcnq1/kcne1 current in cho cells in which cloned kcnq1/kcne1 channels were coexpressed with m1 muscarinic receptors. may associate also with kcne3 (mirp2) to form the potassium channel that is important for cyclic amp-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
16653	probably important in cardiac repolarization. associates with kcne1 (mink) to form the i(ks) cardiac potassium current. elicits a rapidly activating, potassium-selective outward current. muscarinic agonist oxotremorine-m strongly suppresses kcnq1/kcne1 current in cho cells in which cloned kcnq1/kcne1 channels were coexpressed with m1 muscarinic receptors. may associate also with kcne3 (mirp2) to form the potassium channel that is important for cyclic amp-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
16654	
16655	plays a role in apical endocytosis/recycling. may be implicated in transport between the plasma membrane and early endosomes.
16656	nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. coactivates expression in an agonist- and af2-dependent manner. involved in the coactivation of different nuclear receptors, such as for steroids (gr and ers), retinoids (rars and rxrs), thyroid hormone (trs), vitamin d3 (vdr) and prostanoids (ppars). probably functions as a general coactivator, rather than just a nuclear receptor coactivator. may also be involved in the coactivation of the nf-kappa-b pathway. may coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
16657	
16658	possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis (by similarity).
16659	
16660	
16661	interacts with dna-repair protein xrcc1 and can correct defective dna strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
16662	
16663	
16664	
16665	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (by similarity).
16666	
16667	
16668	
16669	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein.
16670	thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. in vitro it binds mhc, f-actin and native thin filaments, and modifies the activity of actin-activated myosin atpase. it may modulate muscle contraction or may play a more structural role.
16671	fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, dna, and actin. fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. interaction with tnr mediates inhibition of cell adhesion and neurite outgrowth (by similarity).
16672	
16673	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
16674	apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. acts as an inhibitor of tnfrsf6 mediated apoptosis. a proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (disc) thereby blocking further recruitment and processing of caspase-8 at the complex. full length and shorter isoforms have been shown either to induce apoptosis or to reduce tnfrsf-triggered apoptosis. lacks enzymatic (caspase) activity.
16675	involved in t-cell antigen receptor mediated signaling.
16676	
16677	may act as a gtpase activating protein for rab family protein(s).
16678	
16679	
16680	
16681	vinexin alpha isoform promotes up-regulation of actin stress fiber formation. vinexin beta isoform plays a role in cell spreading and enhances the activation of jnk/sapk in response to egf stimulation by using its third sh3 domain.
16682	may play a role in growth regulation and in negative regulation of cell cycle progesssion.
16683	
16684	
16685	component of adherens-type cell-cell and cell-matrix junctions. lacks phosphoglucomutase activity.
16686	involved in the regulation of growth and apoptosis. mediates activation of stress-responsive mtk1/mekk4 mapkkk.
16687	
16688	component of the cleavage factor im complex (cfim) that plays a key role in pre-mrna 3@#$%& processing. involved in association with nudt21/cpsf5 in pre-mrna 3@#$%&-end poly(a) site cleavage and poly(a) addition. cpsf6 binds to cleavage and polyadenylation rna substrates.
16689	function in general translation initiation by promoting the binding of the formylmethionine-trna to ribosomes. seems to function along with eif-2.
16690	
16691	
16692	
16693	
16694	may be involved in transcriptional regulation.
16695	type i collagen is a member of group i collagen (fibrillar forming collagen).
16696	
16697	plays an important role in control of proteasome function. inhibits the hydrolysis of protein and peptide substrates by the 20s proteasome. also inhibits the activation of the proteasome by the proteasome regulatory proteins pa700 and pa28.
16698	lif has the capacity to induce terminal differentiation in leukemic cells. its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
16699	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
16700	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
16701	
16702	
16703	
16704	thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity. coactivates six1, and seems to coactivate six2, six4 and six5. the repression of precursor cell proliferation in myoblasts by six1 is switched to activation through recruitment of eya3 to the six1-dach1 complex and seems to be dependent on eya3 phosphatase activity (by similarity). may be involved in development of the eye.
16705	protein transport. probably involved in vesicular traffic (by similarity).
16706	
16707	
16708	subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-golgi network (tgn) to the endosomal-lysosomal system.
16709	
16710	
16711	
16712	
16713	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
16714	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
16715	
16716	
16717	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
16718	
16719	implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. may be involved in the regulation of perinuclear intravesicular membrane traffic (by similarity).
16720	binds with high affinity to rna molecules that contain au-rich elements (ares) found within the 3-prime untranslated regions of many protooncogenes and cytokine mrnas. also binds to double- and single-stranded dna sequences in a specific manner and functions a transcription factor. each of the rna-binding domains specifically can bind solely to a single-stranded non-monotonous 5@#$%&-uuag-3@#$%& sequence and also weaker to the single-stranded 5@#$%&- ttaggg-3@#$%& telomeric dna repeat. binding of rrm1 to dna inhibits the formation of dna quadruplex structure which may play a role in telomere elongation. may be involved in translationally coupled mrna turnover. implicated with other rna-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding-region determinant of instability (mcrd) domain.
16721	
16722	
16723	
16724	may act as scaffold protein.
16725	
16726	phosphorylates serine- and arginine-rich (sr) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable sr proteins to control rna splicing. phosphorylates serines, threonines and tyrosines. required for the regulation of alternative splicing of mapt/tau.
16727	may be involved in cell-cell interactions and recognition.
16728	in cooperation with other chaperones, hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. these chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. they bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
16729	
16730	binds to g-rich structures in 28s rrna and in mrnas. plays a regulatory role in the translation apparatus; inhibits cell-free translation of mrnas.
16731	mediates down-regulation of protein synthesis in response to various stress conditions by the phosphorylation of eif2s1 at ser-48 and ser-51. protein synthesis is inhibited at the level of initiation.
16732	
16733	
16734	growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. binds to the vegfr1/flt-1 and vegfr2/kdr receptors, heparan sulfate and heparin. neuropilin-1 binds isoforms vegf-165 and vegf-145.
16735	activates pro-caspase-1 and pro-caspase-8. potentiates casp8-mediated apoptosis. activates nf-kappa-b.
16736	
16737	
16738	gap class segmentation protein that controls development of head structures.
16739	
16740	
16741	
16742	
16743	essential for the control of the cell cycle at the g1/s (start) transition.
16744	
16745	receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxldl) by vascular endothelial cells. oxldl is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. its association with oxldl induces the activation of nf-kappa-b through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (no) release, monocyte adhesion and apoptosis. in addition to binding oxldl, it acts as a receptor for the hsp70 protein involved in antigen cross-presentation to naive t-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. also acts as a receptor for advanced glycation end (age) products, activated platelets, monocytes, apoptotic cells and both gram-negative and gram- positive bacteria.
16746	
16747	
16748	
16749	tumor-associated antigen.
16750	catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the c-terminus of several proteins. the beta subunit is responsible for peptide-binding.
16751	
16752	
16753	
16754	required for protein transport from the er to the golgi complex.
16755	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
16756	
16757	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
16758	thyroid hormone-binding protein. probably transports thyroxine from the bloodstream to the brain.
16759	
16760	does not act as an allosteric activator of the cholera toxin catalytic subunit (by similarity).
16761	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation by repressing transcription of myocyte enhancer mef2c. during muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.
16762	
16763	chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. signals through ccr2b and ccr3 receptors. plays a role in the accumulation of leukocytes at both sides of allergic and nonallergic inflammation. may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. may play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
16764	component of the dendritic ribonucleoprotein particles (rnps) in hippocampal neurons. may play a role in mrna transport.
16765	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
16766	adf augments the expression of the interleukin-2 receptor tac (il2r/p55).
16767	has phospholipase and triglyceride lipase activities. hydrolyzes high density lipoproteins (hdl) more efficiently than other lipoproteins. binds heparin.
16768	
16769	putative adhesion molecule that mediates sialic-acid dependent binding to cells. preferentially binds to alpha2,3- or 2,6-linked sialic acid. the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
16770	
16771	chemotactic for eosinophils and basophils. binds to ccr3.
16772	
16773	
16774	putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.
16775	dephosphorylates and concomitantly deactivates cam- kinase ii activated upon autophosphorylation, and cam-kinases iv and i activated upon phosphorylation by cam-kinase kinase. promotes apoptosis.
16776	
16777	involved in intracellular signal transduction mediated by cytokines and growth factors. when associated with stam, it suppresses dna signaling upon stimulation by il-2 and gm-csf. could be a direct effector of pi3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. may concentrate ubiquitinated receptors within clathrin-coated regions. involved in down- regulation of receptor tyrosine kinase via multivesicular body (mvbs) when complexed with stam. this complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. may contribute to the efficient recruitment of smads to the activin receptor complex.
16778	atp-dependent rna helicase. acts as a cofactor for xpo1- mediated nuclear export of incompletely spliced hiv-1 rev rnas. also involved in hiv-1 replication. interacts specifically with hepatitis c virus core protein resulting in a change in intracellular location.
16779	
16780	involved in the transport of proteins between the endosomes and the trans golgi network (by similarity).
16781	
16782	
16783	may act as a scaffolding protein within caveolar membranes. interacts directly with g-protein alpha subunits and can functionally regulate their activity (by similarity).
16784	
16785	
16786	
16787	may be involved in transcriptional regulation.
16788	
16789	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
16790	
16791	
16792	
16793	may be involved in transcriptional regulation.
16794	
16795	
16796	necessary for efficient rna polymerase ii transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by s-ii allows the resumption of elongation from the new 3@#$%&terminus.
16797	
16798	
16799	
16800	
16801	
16802	
16803	
16804	
16805	
16806	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
16807	
16808	
16809	
16810	
16811	
16812	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
16813	
16814	
16815	
16816	gtpase-activating protein for rac1 and cdc42. promotes the exchange of rac or cdc42-bound gdp by gtp, thereby activating them. displays serine/threonine kinase activity.
16817	
16818	
16819	
16820	
16821	
16822	
16823	
16824	
16825	
16826	
16827	
16828	component of the mrn complex, which plays a central role in double-strand break (dsb) repair, dna recombination, maintenance of telomere integrity and meiosis. the complex possesses single-strand endonuclease activity and double-strand- specific 3@#$%&-5@#$%& exonuclease activity, which are provided by mre11a. rad50 may be required to bind dna ends and hold them in close proximity. this could facilitate searches for short or long regions of sequence homology in the recombining dna templates, and may also stimulate the activity of dna ligases and/or restrict the nuclease activity of mre11a to prevent nucleolytic degradation past a given point. the complex may also be required for dna damage signaling via activation of the atm kinase. in telomeres the mrn complex may modulate t-loop formation.
16829	
16830	
16831	
16832	plays an important role in the regulation of microtubule (mt) dynamics, regulating the density, length distribution and stability of interphase mts. participates in generating polarized mt networks in migrating fibroblasts.
16833	possibly acts as a transcriptional regulatory factor.
16834	
16835	
16836	regulatory subunit of a gtpase activating protein that has specificity for rab3 subfamily (rab3a, rab3b, rab3c and rab3d). rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. rab3 gtpase-activating complex specifically converts active rab3-gtp to the inactive form rab3- gdp. required for normal eye and brain development. may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and nonsynaptic vesicular release of neurotransmitters.
16837	plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-rna interactions required for accurate 3@#$%& splice site selection. recruits u2 snrnp to the branch point. directly mediates interactions between u2af2 and proteins bound to the enhancers and thus may function as a bridge between u2af2 and the enhancer complex to recruit it to the adjacent intron.
16838	septins are gtpases involved in cytokinesis that assemble into filaments and form a ring at the cleavage site. may act by recruiting myo1 and hof1, a protein involved in septation, to the site of cleavage. septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
16839	plays a role in papillomavirus genes transcription.
16840	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
16841	could be a global transcriptional regulator. modifies gene expression by affecting chromatin. may be involved in brain development and facial morphogenesis.
16842	catalyzes the covalent attachment of ubiquitin to other proteins. in association with the e3 enzyme bre1 and lge1, it plays a role in transcription regulation by catalyzing the monoubiquitination of lys-123 of histone h2b leading to the trimethylation of histone h3 lys-4 by compass, the localization of the paf1 complex to the chromatin and the silencing of telomeric- associated genes. in association with the e3 enzyme rad18, it catalyzes the monoubiquitination of pol30 lys-164, involved in postreplication repair of uv-damaged dna. the ubc2-rad18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine. in association with the e3 enzyme ubr1, is involved in n-end rule-dependent protein degradation. also involved in sporulation.
16843	
16844	
16845	
16846	
16847	may be involved in transcriptional regulation.
16848	acts as a regulatory subunit of the 26 proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
16849	
16850	this protein mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient. it is a tetrodotoxin-resistant na(+) channel isoform. this channel is responsible for the initial upstroke of the action potential in the electrocardiogram.
16851	essential multidomain scaffolding protein required for normal development (by similarity). recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. may play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.
16852	transcriptional repressor.
16853	transcriptional activator (by similarity). binds a gc box motif. could play a role in b-cell growth and development.
16854	may be involved in transcriptional regulation.
16855	
16856	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
16857	it is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. catalyzes the addition of n-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of n-linked sugar chains. it is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.
16858	cleaves ubiquitin fusion protein substrates. binds to the herpes virus protein vmw110 which may therefore modulate its substrate specificity or activity to stabilize viral proteins.
16859	probable transcriptional regulator involved in developmental processes.
16860	catalyzes the posttranslational methylation of isoprenylated c-terminal cysteine residues.
16861	functions in nuclear protein import as an adapter protein for nuclear receptor kpnb1. binds specifically and directly to substrates containing either a simple or bipartite nls motif. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus.
16862	
16863	
16864	
16865	
16866	
16867	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
16868	probable scaffold protein that may be involved in mrna transport (potential).
16869	
16870	transcriptional activator required for the development of normal hearing, sense of balance and kidney function. required for the expression of slc26a4/pds, jag1 and coch in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. also required for the expression of slc4a1/ae1, slc4a9/ae4, atp6v1b1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (by similarity).
16871	
16872	probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. is not an essential protein. involved in substrate recognition in ubiquitin-dependent degradation.
16873	
16874	enhances caspase-9-mediated apoptosis. induces nf-kappa- b activity via rick (cardiak, rip2) and ikk-gamma. confers responsiveness to intracellular bacterial lipopolysaccharides (lps).
16875	
16876	may be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system (by similarity).
16877	can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses. may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
16878	
16879	catalyzes the phosphorylation of phosphatidylinositol-4- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol-4,5-biphosphate. acts downstream of stt4, but in a pathway that does not involve pkc1. may be involved in the organization of the actin cytoskeleton.
16880	receptor tyrosine kinase that is a key mediator of agrin@#$%&s action and is involved in neuromuscular junction (nmj) organization (by similarity).
16881	receptor for the hormone galanin. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity.
16882	
16883	
16884	
16885	may play a role in the regulation of psen2 proteolytic processing and apoptosis. together with psen2 involved in modulation of beta-amyloid formation.
16886	functions as a sorting receptor in the golgi compartment and as a clearance receptor on the cell surface. required for protein transport from the golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (m6pr). also required for protein transport from the golgi apparatus to the endosomes. promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of bdnf (probdnf) and ngfb (prongfb). also acts as a receptor for neurotensin. may promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular lpl. probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter slc2a4/glut4 (glut4 storage vesicles, or gsvs). these vesicles provide a stable pool of slc2a4 and confer increased responsiveness to insulin. may also mediate transport from the endoplasmic reticulum to the golgi.
16887	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release. inhibits both auto-ubiquitination of park2 and ubiquitination of target proteins by park2 (by similarity).
16888	catalyzes c14-demethylation of lanosterol; it transforms lanosterol into 4,4@#$%&-dimethyl cholesta-8,14,24-triene-3-beta-ol.
16889	
16890	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. mct2 is a high affinity pyruvate transporter.
16891	
16892	catalyzes the covalent attachment of ubiquitin to other proteins. mediates the selective degradation of short-lived and abnormal proteins. functions in the e6/e6-ap-induced ubiquitination of p53/tp53.
16893	
16894	
16895	
16896	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1a gives rise to p and/or q-type calcium currents. p/q-type calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group and are blocked by the funnel toxin (ftx) and by the omega-agatoxin- iva (omega-aga-iva). they are however insensitive to dihydropyridines (dhp), and omega-conotoxin-gvia (omega-ctx-gvia).
16897	muscle contraction.
16898	degrades extracellular matrix. exhibits trypsin-like activity as defined by cleavage of synthetic substrates with arg or lys as the p1 site (by similarity).
16899	
16900	essential for the proper assembly of the glomerular and tubular basement membranes in kidney (by similarity).
16901	
16902	probable atp-dependent rna helicase. may play a role in spermatogenesis.
16903	
16904	
16905	
16906	
16907	
16908	
16909	transcription factor that binds to the octamer motif (5@#$%&-atttgcat-3@#$%&). thought to be involved in early embryogenesis and neurogenesis.
16910	cellular role is not yet known.
16911	
16912	receptor involved in the costimulatory signal essential for t-lymphocyte proliferation and interleukin 2 production, by binding cd28 or ctla-4. may play a critical role in the early events of t-cell activation and costimulation of naive t-cells, such as deciding between immunity and anergy that is made by t- cells within 24 hours after activation. isoform 2 interferes with the formation of cd86 clusters, and thus acts as a negative regulator of t-cell activation.
16913	
16914	regulatory light chain of myosin. does not bind calcium.
16915	
16916	seems to have a role in retrograde membrane traffic at the level of the golgi complex.
16917	essential multidomain scaffolding protein required for normal development (by similarity). recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. may play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.
16918	
16919	in vitro, acts as a receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5).
16920	probable morphogenetic role. may play a role in limb- pattern formation. in osteoblasts, suppresses transcription driven by the osteocalcin fgf response element (ocfre).
16921	probable morphogenetic role. may play a role in limb- pattern formation. in osteoblasts, suppresses transcription driven by the osteocalcin fgf response element (ocfre).
16922	
16923	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
16924	protein transport. regulator of membrane traffic from the golgi apparatus towards the endoplasmic reticulum (er). has a low gtpase activity.
16925	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
16926	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
16927	
16928	
16929	
16930	plays a role in apical endocytosis/recycling. may be implicated in transport between the plasma membrane and early endosomes.
16931	inhibitor of protein-phosphatase 1. this protein may be important in hormonal control of glycogen metabolism. hormones that elevate intracellular camp increase i-1 activity in many tissues. i-1 activation may impose camp control over proteins that are not directly phosphorylated by pka. following a rise in intracellular calcium, i-1 is inactivated by calcineurin (or pp2b). does not inhibit type-2 phosphatases.
16932	
16933	
16934	
16935	
16936	may be a negative regulator of transcription, but can activate transcription when coexpressed with ras, src or mos. forms a ternary complex with the serum response factor and the ets and srf motifs of the fos serum response element.
16937	stimulates the proliferation of mast cells. able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. mediates also cell-cell adhesion. acts synergistically with other cytokines, probably interleukins.
16938	may play a role in junctional plaques.
16939	may play a role in germ line formation.
16940	acts at e2f-responsive promoters to integrate signals provided by phd- and/or bromodomain-containing transcription factors (by similarity).
16941	probable transcription factor. may play an important role in recruitment of elf4 into pml nuclear bodies.
16942	medin is the main constituent of aortic medial amyloid.
16943	may be involved in transcriptional regulation.
16944	
16945	
16946	
16947	shows chemotactic activity for monocytes, resting t- lymphocytes, and neutrophils, but not for activated lymphocytes. inhibits proliferation of myeloid progenitor cells in colony formation assays. this protein can bind heparin. binds ccr1. ccl23(19-99), ccl23(22-99), ccl23(27-99), ccl23(30-99) are more potent chemoattractants than the small inducible cytokine a23.
16948	regulates the gdp/gtp exchange reaction of the rho proteins by inhibiting the dissociation of gdp from them, and the subsequent binding of gtp to them (by similarity).
16949	required for protein transport from the er to the golgi complex.
16950	
16951	
16952	
16953	
16954	binds to the dendritic targeting element and may play a role in mrna trafficking (by similarity). part of a ternary complex that binds to the downstream control sequence (dcs) of the pre-mrna. mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. may interact with single- stranded dna from the far-upstream element (fuse). may activate gene expression. also involved in degradation of inherently unstable mrnas that contain au-rich elements (ares) in their 3@#$%& untranslated regions, possibly by recruiting degradation machinery to are-containing mrnas.
16955	
16956	
16957	involved in cdc48-dependent protein degradation through the ubiquitin/proteasome pathway. direct or indirect positive regulator of glc7 activity.
16958	
16959	involved in tethering the chromosomes to the spindle pole and in chromosome movement. microtubule-based anterograde translocator for membranous organelles. plus end-directed microtubule sliding activity in vitro (by similarity).
16960	has peptide-independent atpase activity.
16961	
16962	responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. may play a role in the transport of porphyrins and heme.
16963	stimulates the gtpase activity of tubulin, but does not enhance tubulin heterodimerization. acts as guanine nucleotide dissociation inhibitor for arl3.
16964	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
16965	unknown. may be involved in differentiation of metanephric precursor cells.
16966	
16967	involved in mitochondrial transcription regulation. required for accurate and efficient promoter recognition by the mitochondrial rna polymerase. activates transcription by binding immediately upstream of transcriptional start sites. is able to unwind and bend dna.
16968	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
16969	
16970	in the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (krtap), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. the matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
16971	
16972	
16973	
16974	involved in the ubiquitination and subsequent proteasomal degradation via the von hippel-lindau ubiquitination complex. seems to act as target recruitment subunit in the e3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (hif) under normoxic conditions. involved in transcriptional repression through interaction with hif1a, hif1an and histone deacetylases.
16975	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
16976	
16977	
16978	
16979	
16980	
16981	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
16982	the soluble isoform 2 binds vegf-165 and appears to inhibit its binding to cells. it may also induce apoptosis by sequestering vegf-165. may bind as well various members of the semaphorin family. its expression has an averse effect on blood vessel number and integrity.
16983	
16984	
16985	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
16986	
16987	
16988	specific receptor for the autocrine motility factor.
16989	
16990	may be involved in the secretory process of mast cells and may play some role in signal transduction pathways.
16991	
16992	
16993	
16994	
16995	
16996	
16997	
16998	
16999	
17000	
17001	stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers (by similarity).
17002	
17003	
17004	
17005	
17006	
17007	
17008	
17009	electrically silent transporter system. mediates sodium and chloride reabsorption. plays a vital role in the regulation of ionic balance and cell volume.
17010	muscle contraction.
17011	motor for anterograde axonal transport of synaptic vesicle precursors (by similarity).
17012	
17013	may play a role in nucleosome assembly by neutralizing basic proteins such as a and b core hnrnps (by similarity).
17014	
17015	
17016	
17017	probable e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. non essential.
17018	acts on galnac. also acts as a galactokinase when galactose is present at high concentrations.
17019	
17020	
17021	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
17022	
17023	
17024	
17025	may function in the secretion of milk-fat droplets. may act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (by similarity).
17026	binds single-stranded rna. has a high affinity for g- rich and u-rich regions of hnrna. also binds to apob mrna transcripts around the rna editing site.
17027	binds to isre-like element (interferon-stimulated response element) of myc p2 promoter.
17028	
17029	
17030	
17031	
17032	binds specifically to oligomers of e-box motifs. may play important roles during development of the nervous system as well as in other organ systems.
17033	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
17034	activates erythroid-specific, globin gene expression.
17035	reversible hydration of carbon dioxide.
17036	
17037	
17038	
17039	interacts with c-terminus of pcna. 5@#$%& phosphate residue is required for binding of the n-terminal dna-binding domain to duplex dna, suggesting a role in recognition of non-primer template dna structures during replication and/or repair.
17040	transcriptional corepressor that binds to a number of transcription factors. inhibits the transcriptional activation mediated by ctnnb1 and tcf family members in wnt signaling. the effects of full-length tle family members may be modulated by association with dominant-negative aes (by similarity).
17041	
17042	rapidly transports ca(2+) during excitation-contraction coupling. ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
17043	contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.
17044	vimentins are class-iii intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.
17045	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of the calcium.
17046	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of the calcium.
17047	the soluble isoform 2 binds vegf-165 and appears to inhibit its binding to cells. it may also induce apoptosis by sequestering vegf-165. may bind as well various members of the semaphorin family. its expression has an averse effect on blood vessel number and integrity.
17048	the 83 kda subunit binds and stabilizes the catalytic subunit at 37 degrees celsius and keeps it in circulation. under some circumstances it may be an allosteric modifier of the catalytic subunit.
17049	
17050	
17051	
17052	muscle contraction.
17053	this protein promotes the gtp-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome (by similarity).
17054	could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by ngf. may be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (by similarity).
17055	involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. shows high catalytic efficiency for hydrolysis of 4-methyumbelliferyl acetate, heroin and 6-monoacetylmorphine.
17056	may be involved in transcriptional regulation.
17057	
17058	may act at junctions between the membrane and the cytoskeleton.
17059	contributes to the lung@#$%&s defense against inhaled microorganisms. binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. it could participate in the extracellular reorganization or turnover of pulmonary surfactant.
17060	
17061	functions in the early steps of protein synthesis by forming a ternary complex with gtp and initiator trna. this complex binds to a 40s ribosomal subunit, followed by mrna binding to form a 43s preinitiation complex. junction of the 60s ribosomal subunit to form the 80s initiation complex is preceded by hydrolysis of the gtp bound to eif-2 and release of an eif-2-gdp binary complex. in order for eif-2 to recycle and catalyze another round of initiation, the gdp bound to eif-2 must exchange with gtp by way of a reaction catalyzed by eif-2b.
17062	
17063	
17064	glycosyltransferase that initiates the elongation of o- linked fucose residues attached to egf-like repeats in the extracellular domain of notch molecules. may be involved in limb formation and in neurogenesis (by similarity).
17065	
17066	may play a regulatory role in synaptic vesicle recycling.
17067	
17068	major component of the descemet@#$%&s membrane (basement membrane) of corneal endothelial cells.
17069	
17070	involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26s proteasome (by similarity).
17071	catalyzes the reaction that attaches fucose through an o-glycosidic linkage to a conserved serine or threonine residue in thrombospondin type 1 repeats.
17072	
17073	capable of removing ubiquitin from ubiquitinated proteins; also capable of removing nedd8 from nedd8 conjugates but has no effect on sentrin-1 conjugates.
17074	may be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
17075	
17076	
17077	isoform gamma is a site-specific single-strand endoribonuclease that cleaves single strand rna 3@#$%& to purines and pyrimidines in a+u-rich regions. it generates 5@#$%&-phosphate termini at the site of cleavage. this isoform does not inhibit pp-1. may be implicated in mrna splicing.
17078	
17079	
17080	
17081	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis (by similarity).
17082	this protein is a minor sialoglycoprotein in human erythrocyte membranes. the blood group gerbich antigens and receptors for plasmodium falciparum merozoites are most likely located within the extracellular domain. glycophorin c plays an important role in regulating the stability of red cells.
17083	
17084	
17085	isoform c is proteolytically inactive.
17086	may be involved in the physiological processes of brain function. has no dipeptidyl aminopeptidase activity. may modulate the cell surface expression and the activity of the potassium channel kcnd2 (by similarity).
17087	adds a myristoyl group to the n-terminal glycine residue of certain cellular and viral proteins.
17088	
17089	may be involved in several stages of intracellular trafficking (by similarity).
17090	
17091	cleaves the propeptides of type i and ii collagen prior to fibril assembly. does not act on type iii collagen. may also play a role in development that is independent of its role in collagen biosynthesis.
17092	
17093	may play a role in the development and maintenance of the vertebrate nervous system.
17094	may be involved in macrophage-mediated cellular proliferation. it is mitogenic for fibroblasts and smooth muscle but not endothelial cells. it is able to bind egf receptors with higher affinity than egf itself and is a far more potent mitogen for smooth muscle cells than egf. also acts as a diphtheria toxin receptor.
17095	
17096	may activate cdc42, a member of the ras-like family of rho- and rac proteins, by exchanging bound gdp for free gtp. may play a role in regulating the actin cytoskeleton and cell shape (by similarity).
17097	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
17098	
17099	
17100	
17101	essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.
17102	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
17103	
17104	
17105	muscle contraction.
17106	
17107	inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. inhibins appear to oppose the functions of activins.
17108	
17109	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. isoform serca2a is involved in the regulation of the contraction/relaxation cycle.
17110	
17111	polymerase that creates the 3@#$%& poly(a) tail of mrna@#$%&s. also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. may acquire specificity through interaction with a cleavage and polyadenylation specificity factor (cpsf) at its c-terminus.
17112	
17113	
17114	adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. can bind to fibrinogen, fibronectin, laminin, type v collagen and integrins alpha-v/beta-1, alpha- v/beta-3 and alpha-iib/beta-3.
17115	
17116	
17117	function in general translation initiation by promoting the binding of the formylmethionine-trna to ribosomes. seems to function along with eif-2.
17118	
17119	
17120	
17121	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
17122	
17123	atp-dependent rna helicase involved nonsense-mediated mrna decay and ribosome biogenesis through rrna processing.
17124	may play some role in mitochondrial processes.
17125	inhibits nf-kappa-b activation. may participate in a regulatory mechanism that coordinates cellular responses controlled by nf-kappa-b transcription factor. may be a component of the inflammasome, a protein complex which also includes pycard, nalp2 and casp1 and whose function would be the activation of proinflammatory caspases.
17126	
17127	
17128	acts on phosphatidylinositol (ptdins) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate.
17129	probably involved in the organization of the actin cytoskeleton. induced membrane extensions in fibroblasts.
17130	
17131	
17132	
17133	
17134	
17135	
17136	
17137	
17138	
17139	immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. participates also in the recruitment of tyrosine kinase syk.
17140	
17141	
17142	
17143	
17144	
17145	
17146	
17147	
17148	
17149	
17150	
17151	
17152	
17153	
17154	
17155	
17156	
17157	
17158	
17159	
17160	
17161	
17162	
17163	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
17164	
17165	
17166	
17167	component of adherens-type cell-cell and cell-matrix junctions. lacks phosphoglucomutase activity.
17168	
17169	
17170	
17171	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
17172	plays a role in modulation of e3 ubiquitin ligase activity of the 2 subunit brca1/bard1 complex.
17173	
17174	
17175	
17176	transcription factor that binds to the octamer motif (5@#$%&-atttgcat-3@#$%&). prime candidate for an early developmental control gene.
17177	
17178	
17179	
17180	
17181	
17182	
17183	implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.
17184	
17185	
17186	
17187	involved in the presentation of foreign antigens to the immune system.
17188	
17189	
17190	
17191	
17192	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
17193	motor required for the retrograde transport of golgi vesicles to the endoplasmic reticulum. has a microtubule plus end- directed motility.
17194	involved in the biogenesis of rrna (by similarity).
17195	
17196	
17197	required for protein transport from the er to the golgi complex.
17198	
17199	
17200	
17201	
17202	
17203	
17204	
17205	
17206	molecular chaperone. has atpase activity (by similarity).
17207	
17208	catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. has little activity towards prostaglandins a1 and e1.
17209	orphan receptor.
17210	component of a protein kinase signal transduction cascade. activates the jnk, but not erk or p38 kinase pathways.
17211	
17212	
17213	sequence-specific rna-binding protein which participates in the control of pre-mrna splicing.
17214	catalyzes the reaction that attaches fucose through an o-glycosidic linkage to a conserved serine or threonine residue in thrombospondin type 1 repeats.
17215	
17216	
17217	core component of nucleosome. nucleosomes wrap and compact dna into chromatin, limiting dna accessibility to the cellular machineries which require dna as a template. histones thereby play a central role in transcription regulation, dna repair, dna replication and chromosomal stability. dna accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodelling.
17218	arm and abl proteins function cooperatively at adherens junctions in both the cns and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone@#$%&s response to midline cues. the ability of pcc/mp2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both slit/robo and abl-dependent signaling pathways.
17219	can unwind double-stranded rna (helicase) and can fold or introduce a secondary structure to a single-stranded rna (foldase). functions as cofactor for c-jun-activated transcription (by similarity).
17220	
17221	
17222	
17223	
17224	3@#$%&-exoribonuclease that has a preference for poly(a) tails of mrnas, thereby efficiently degrading poly(a) tails. exonucleolytic degradation of the poly(a) tail is often the first step in the decay of eukaryotic mrnas and is also used to silence certain maternal mrnas translationally during oocyte maturation and early embryonic development. interacts with both the 3@#$%&-end poly(a) tail and the 5@#$%&-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(a) tails. involved in nonsense-mediated mrna decay, a critical process of selective degradation of mrnas that contain premature stop codons. also involved in degradation of inherently unstable mrnas that contain au-rich elements (ares) in their 3@#$%& untranslated regions, possibly via its interaction with khsrp. probably mediates the removal of poly(a) tails of ares mrnas, which constitutes the first step of destabilization.
17225	
17226	may be involved in transcriptional regulation.
17227	
17228	
17229	
17230	
17231	involved in dna double strand break (dsb) repair.
17232	
17233	
17234	septins are gtpases involved in cytokinesis that assemble into filaments and form a ring at the cleavage site. may act by recruiting myo1 and hof1, a protein involved in septation, to the site of cleavage. septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
17235	
17236	
17237	
17238	a probable role in alternative splice site selection during pre-mrna splicing.
17239	receptor for obesity factor (leptin). on ligand binding, mediates signaling through jak2/stat3. involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. may play a role in reproduction. can also mediate the erk/fos signaling pathway (by similarity).
17240	
17241	
17242	
17243	
17244	
17245	phosphorylase is an important allosteric enzyme in carbohydrate metabolism. enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. however, all known phosphorylases share catalytic and structural properties.
17246	catalyzes the covalent attachment of ubiquitin to other proteins. mediates the selective degradation of short-lived and abnormal proteins.
17247	most upstream protease of the activation cascade of caspases responsible for the tnfrsf6/fas mediated and tnfrsf1a induced cell death. binding to the adapter molecule fadd recruits it to either receptor. the resulting aggregate called death- inducing signaling complex (disc) performs casp8 proteolytic activation. the active dimeric enzyme is then liberated from the disc and free to activate downstream apoptotic proteases. proteolytic fragments of the n-terminal propeptide (termed cap3, cap5 and cap6) are likely retained in the disc. cleaves and activates casp3, casp4, casp6, casp7, casp9 and casp10. may participate in the gzmb apoptotic pathways. cleaves adprt. hydrolyzes the small-molecule substrate, ac-asp-glu-val-asp-|-amc. likely target for the cowpox virus crma death inhibitory protein. isoforms 5, 6, 7 and 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
17248	
17249	
17250	required for pseudopod elongation in transformed cells.
17251	receptor for a c-c type chemokine. binds to mip-1-alpha, mip-1-delta, rantes, and mcp-3 and, less efficiently, to mip-1- beta or mcp-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. responsible for affecting stem cell proliferation.
17252	inhibits the auto- and transphosphorylation activity of btk. plays a negative regulatory role in btk-related cytoplasmic signaling in b-cells. may be involved in bcr-induced apoptotic cell death.
17253	component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. three proteases; ndl, gd and snk process easter to create active easter. active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the tl receptor in the ventral region of the embryo. promotes heterophilic cellular adhesion. spz c-106 in the hemolymph controls expression of the antifungal peptide drosomycin (drs) by acting as a ligand of tl and inducing an intracellular signaling pathway.
17254	
17255	probably has no proteolytic activity, since crucial aa characteristic of serine proteases catalytic sites are not conserved.
17256	may play a role in organizing the actin cytoskeleton.
17257	
17258	may regulate vesicle function in the growth cone (by similarity).
17259	
17260	
17261	
17262	stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers (by similarity).
17263	
17264	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
17265	
17266	
17267	
17268	
17269	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. this receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. it is a cation-specific, but otherwise relatively nonselective, ion channel.
17270	
17271	
17272	probably required for protein import into peroxisomes. anchors pex1 and pex6 to peroxisome membranes, possibly to form heteromeric aaa atpase complexes required for the import of proteins into peroxisomes. involved in the import of catalase and proteins containing a pts22 target sequence, but not in import of proteins with a pts1 target sequence.
17273	probably required for protein import into peroxisomes. anchors pex1 and pex6 to peroxisome membranes, possibly to form heteromeric aaa atpase complexes required for the import of proteins into peroxisomes. involved in the import of catalase and proteins containing a pts22 target sequence, but not in import of proteins with a pts1 target sequence.
17274	
17275	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. this receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. it is a cation-specific, but otherwise relatively nonselective, ion channel.
17276	
17277	prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (er). binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (srp), which normally targets nascent secretory peptides to the er. also reduces the inherent affinity of ribosomes for protein translocation sites in the er membrane (m sites). may act as a specific coactivator for jun, binding to dna and stabilizing the interaction of jun homodimers with target gene promoters.
17278	molecular chaperone that functions in the processing and transport of secreted proteins (by similarity).
17279	
17280	
17281	
17282	
17283	the s.cerevisiae ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-amp.
17284	
17285	
17286	possesses a trypsin-like cleavage specificity.
17287	
17288	
17289	may be signaling molecules that resemble neuropeptides. ligand for alpha-neurexins (by similarity).
17290	accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. alters functional properties of kv1.4.
17291	in the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (krtap), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. the matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
17292	
17293	
17294	not known.
17295	
17296	may be involved in transcriptional regulation.
17297	
17298	capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.
17299	binds to the caccc box in the beta-globin gene promoter and activates transcription (by similarity).
17300	transcriptional repressor.
17301	protein kinase that plays an important role in cellular stress response. activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic foxo3a. phosphorylates nedd4l, which leads to its inactivation and to the subsequent activation of various channels and transporters such as enac, kv1.3, or eaat1.
17302	destroys radicals which are normally produced within the cells and which are toxic to biological systems.
17303	probably methylates the guanidino nitrogens of arginyl residues in some proteins. may play a role in transcriptional coactivation.
17304	
17305	
17306	dna- and rna binding protein, involved in several nuclear processes. binds the conventional octamer sequence in double stranded dna. also binds single-stranded dna and rna at a site independent of the duplex site (by similarity). involved in pre-mrna splicing, probably as an heterodimer with sfpq. interacts with u5 snrna, probably by binding to a purine-rich sequence located on the 3@#$%& side of u5 snrna stem 1b. the sfpq-nono heteromer associated with matr3 may play a role in nuclear retention of defective rnas. the sfpq-nono heteromer may be involved in dna unwinding by modulating the function of topoisomerase i/top1. the sfpq-nono heteromer may be involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination and may stabilize paired dna ends. in vitro, the complex strongly stimulates dna end joining, binds directly to the dna substrates and cooperates with the ku70/g22p1-ku80/xrcc5 (ku) dimer to establish a functional preligation complex. nono is involved in transcriptional regulation. the sfpq-nono-nr5a1/sf-1 complex binds to the cyp17 promoter and regulates basal and camp-dependent transcriptional avtivity. nono binds to an enhancer element in long terminal repeats of endogenous intracisternal a particles (iaps) and activates transcription (by similarity).
17307	
17308	
17309	
17310	
17311	
17312	
17313	
17314	
17315	
17316	
17317	
17318	
17319	
17320	plays an important role in the elongation step of protein synthesis.
17321	
17322	
17323	
17324	
17325	
17326	
17327	
17328	
17329	
17330	
17331	binds to and inhibits the transcriptional repressor zbtb33, which may lead to activation of target genes of the wnt signaling pathway (by similarity). may associate with and regulate the cell adhesion properties of both c- and e-cadherins. implicated both in cell transformation by src and in ligand- induced receptor signaling through the egf, pdgf, csf-1 and erbb2 receptors.
17332	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. displays high levels of activity on medium- and long chain acyl coas.
17333	gtpase-activating protein for rac1 and cdc42. promotes the exchange of rac or cdc42-bound gdp by gtp, thereby activating them. displays serine/threonine kinase activity.
17334	
17335	
17336	
17337	
17338	
17339	
17340	
17341	
17342	
17343	
17344	may be involved in transcriptional regulation.
17345	
17346	type i collagen is a member of group i collagen (fibrillar forming collagen).
17347	works in concert with the 5alpha/5beta-steroid reductases to convert steroid hormones into the 3alpha/5alpha and 3alpha/5beta-tetrahydrosteroids. catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5alpha-dht) to 5-alpha-androstane-3alpha,17beta-diol (3-alpha-diol).
17348	
17349	
17350	
17351	
17352	
17353	
17354	
17355	
17356	
17357	
17358	
17359	
17360	
17361	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
17362	
17363	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb (by similarity).
17364	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
17365	
17366	
17367	
17368	
17369	
17370	plays a role in papillomavirus genes transcription.
17371	
17372	essential for biological clock functions. determines the period length of circadian and ultradian rhythms; an increase in per dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. the biological cycle depends on the rhythmic formation and nuclear localization of the tim-per complex. light induces the degradation of tim, which promotes elimination of per. nuclear activity of the heterodimer coordinatively regulates per and tim transcription through a negative feedback loop. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition.
17373	catalyzes three sequential methylation of phosphatidylethanolamine (pe) by adomet, thus producing phosphatidylcholine (pc).
17374	
17375	
17376	component of the fact complex, a general chromatin factor that acts to reorganize nucleosomes. the fact complex is involved in multiple processes that require dna as a template such as mrna elongation, dna replication and dna repair. during transcription elongation the fact complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. it facilitates the passage of rna polymerase ii and transcription by promoting the dissociation of one histone h2a-h2b dimer from the nucleosome, then subsequently promotes the reestablishement of the nucleosome following the passage of rna polymerase ii. transcription elongation is promoted by the repression of transcription initiation from cryptic sites. also acts in establishing transcription initiation complexes and promotes spt15/tbp-binding to a tata box. together with replication factor-a protein (rpa), fact may play a role in nucleosome deposition during dna replication.
17377	gtp-binding protein with gtpase activity. elicits the formation of f-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (by similarity).
17378	
17379	promotes the exchange of cdc42-bound gdp by gtp. controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. cdc24 may be involved in the initial selection and organization of the budding site.
17380	
17381	
17382	
17383	may be involved in dna repair.
17384	
17385	
17386	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
17387	may mediate the control of various cellular processes by insulin.
17388	converts big endothelin-1 to endothelin-1.
17389	receptor for angiotensin ii. mediates its action by association with g proteins that activate a phosphatidylinositol- calcium second messenger system.
17390	
17391	
17392	
17393	
17394	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
17395	
17396	
17397	
17398	phosphorylates inhibitors of nf-kappa-b thus leading to the dissociation of the inhibitor/nf-kappa-b complex and ultimately the degradation of the inhibitor. also phosphorylates ncoa3 (by similarity).
17399	
17400	reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. involved in intracellular redox signaling.
17401	
17402	
17403	
17404	
17405	
17406	
17407	may act as a zinc-influx transporter.
17408	
17409	
17410	
17411	may be involved in transcriptional regulation.
17412	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
17413	
17414	
17415	potassium channel activated by both membrane depolarization or increase in cytosolic ca(2+) that mediates export of k(+). it is also activated by the concentration of cytosolic mg(2+). its activation dampens the excitatory events that elevate the cytosolic ca(2+) concentration and/or depolarize the cell membrane. it therefore contributes to repolarization of the membrane potential. plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. in smooth muscles, its activation by high level of ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. in cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. kinetics of kcnma1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. highly sensitive to both iberiotoxin (ibtx) and charybdotoxin (ctx).
17416	transcriptional activator which recognizes variations of the palindromic sequence 5@#$%&-attcccnngggaatt-3@#$%&.
17417	
17418	
17419	
17420	
17421	
17422	
17423	involved in accumulation of zinc in synaptic vesicles.
17424	
17425	binds to activated (phosphorylated) protein-tyrosine kinases through its sh2 domain and regulates their kinase activity. during insulin stimulation, it also binds to irs-1.
17426	required only in the female germ line. it is important for oocyte formation and in the specification of the posterior structures of the embryo.
17427	
17428	
17429	
17430	
17431	
17432	
17433	
17434	serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as tnf-alpha. appears to act upstream of the jun n-terminal pathway.
17435	involved in the ubiquitination and subsequent proteasomal degradation via the von hippel-lindau ubiquitination complex. seems to act as target recruitment subunit in the e3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (hif) under normoxic conditions. involved in transcriptional repression through interaction with hif1a, hif1an and histone deacetylases.
17436	
17437	
17438	
17439	involved in mediating u snrna export from the nucleus. binds to 5@#$%& capped mrna.
17440	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. this subunit is involved in antigen processing to generate class i binding peptides.
17441	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
17442	
17443	
17444	
17445	
17446	interacts with naf1 and inhibits tnf-induced nf-kappa-b- dependent gene expression by interfering with an rip- or traf2- mediated transactivation signal. inhibitor of programmed cell death. has a role in the function of the lymphoid system and may contribute to the in vivo effects of tnf (by similarity). has deubiquitinating activity that is directed towards lys-48 or lys- 63-linked polyubiquitin chains.
17447	
17448	
17449	
17450	this inhibitor acts as @#$%&bait@#$%& for tissue plasminogen activator, urokinase, and protein c. its rapid interaction with tpa may function as a major control point in the regulation of fibrinolysis.
17451	
17452	
17453	
17454	
17455	possible architectural role during spermatogenesis. may be involved in spermatid differentiation.
17456	
17457	appears to mediate interactions between cells and the extracellular matrix. substrate-adhesion molecule that appears to inhibit cell migration. may play a role in supporting the growth of epithelial tumors.
17458	
17459	
17460	involved in transport from the endoplasmic reticulum to the golgi apparatus (by similarity).
17461	
17462	
17463	type i collagen is a member of group i collagen (fibrillar forming collagen).
17464	involved in repair of uv radiation-induced dna damage. catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same dna strand upon exposure to ultraviolet radiation.
17465	binds to membranes enriched in phosphatidylinositol-4,5- biphosphate (ptdins(4,5)p2). modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (by similarity). regulates receptor-mediated endocytosis.
17466	
17467	binds to membranes enriched in phosphatidylinositol-4,5- biphosphate (ptdins(4,5)p2). modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (by similarity). regulates receptor-mediated endocytosis.
17468	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1c gives rise to l-type calcium currents. long-lasting (l-type) calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group. they are blocked by dihydropyridines (dhp), phenylalkylamines, benzothiazepines, and by omega-agatoxin-iiia (omega-aga-iiia). they are however insensitive to omega-conotoxin- gvia (omega-ctx-gvia) and omega-agatoxin-iva (omega-aga-iva). calcium channels containing the alpha-1c subunit play an important role in excitation-contraction coupling in the heart. the various isoforms display marked differences in the sensitivity to dhp compounds.
17469	binds to the il-1 type i receptor following il-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mrna stabilization. the kinase activity of this enzyme may not be required for il-1 signaling. once phosphorylated, irak1 recruits the adapter protein peli1.
17470	activates cdc42, a member of the ras-like family of rho- and rac proteins, by exchanging bound gdp for free gtp. plays a role in regulating the actin cytoskeleton and cell shape.
17471	
17472	
17473	
17474	ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. covalent attachment to its substrates requires prior activation by the e1 complex ube1c- appbp1 and linkage to the e2 enzyme ube2m. attachment of nedd8 to cullins activates their associated e3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
17475	
17476	the activated kinase acts on a variety of targets. likely to be the gtpase effector that links the rho-related gtpases to the jnk map kinase pathway. activated by cdc42 and rac1. involved in dissolution of stress fibers and reorganization of focal complexes. activity is inhibited in cells undergoing apoptosis, potentially due to binding of cdc2l1 and cdc2l2 (by similarity).
17477	high affinity permease for methionine.
17478	
17479	collagen type iii occurs in most soft connective tissues along with type i collagen.
17480	
17481	
17482	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&. activates transcription of pf4 in complex with meis1.
17483	may be involved in transcriptional regulation.
17484	mannose-specific lectin. may recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. the lman1-mcfd2 complex forms a specific cargo receptor for the er-to-golgi transport of selected proteins.
17485	
17486	
17487	may be a member of a yet unidentified signaling pathway and it may act as a tumor-suppressor.
17488	
17489	may play a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. there are four molecules of fkbp12 per skeletal muscle ryr. ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
17490	
17491	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
17492	
17493	
17494	
17495	cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (by similarity).
17496	
17497	
17498	
17499	
17500	may be involved in neurite outgrowth.
17501	
17502	
17503	muscle contraction.
17504	isoform 4 may play a role in spermatogenesis.
17505	
17506	
17507	
17508	
17509	
17510	
17511	
17512	
17513	
17514	
17515	
17516	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. displays high levels of activity on medium- and long chain acyl coas.
17517	
17518	
17519	inhibits nf-kappa-b by complexing with and trapping it in the cytoplasm. however, the unphosphorylated form resynthesized after cell stimulation is able to bind nf-kappa-b allowing its transport to the nucleus and protecting it to further ikba- dependent inactivation. association with inhibitor kappa b- interacting nkiras1 and nkiras2 prevent its phosphorylation rendering it more resistant to degradation, explaining its the slower degradation.
17520	
17521	
17522	
17523	
17524	
17525	
17526	
17527	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
17528	
17529	
17530	
17531	
17532	
17533	
17534	
17535	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
17536	
17537	
17538	
17539	
17540	
17541	
17542	
17543	
17544	
17545	in vitro, acts as a receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5).
17546	
17547	
17548	
17549	
17550	
17551	
17552	
17553	
17554	involved in the presentation of foreign antigens to the immune system.
17555	
17556	
17557	gtpase-activating protein for rac1 and cdc42. promotes the exchange of rac or cdc42-bound gdp by gtp, thereby activating them. displays serine/threonine kinase activity.
17558	
17559	
17560	membrane-cytoskeleton linker. the neural-specific isoforms may participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of ranvier and axonal initial segments.
17561	catalyzes the cyclization of (s)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
17562	plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with rims1, rims2, cacna1d and cacna1b (by similarity).
17563	
17564	
17565	
17566	
17567	
17568	could have a regulatory function in meiosis.
17569	
17570	
17571	
17572	
17573	
17574	it has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1. it is essential for growth or germination at 37 degrees celsius. may have a role in the heat shock response. involved in trna splicing and cell separation.
17575	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. lamin a and c are present in equal amounts in the lamina of mammals.
17576	
17577	
17578	this is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
17579	
17580	
17581	
17582	
17583	
17584	
17585	
17586	
17587	has a transcriptional repressor activity by cooperating with epc1. induces apoptosis by activating jun n-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. may function in male germ cell development. has dna-binding activity and preferentially bound to double-stranded dna (by similarity).
17588	
17589	
17590	involved in vesicular protein trafficking.
17591	
17592	
17593	
17594	
17595	
17596	
17597	
17598	
17599	required for protein transport from the er to the golgi complex.
17600	
17601	
17602	
17603	
17604	
17605	
17606	
17607	
17608	may have a role in the regulation of spermatogenesis.
17609	
17610	
17611	
17612	may be involved in transcriptional regulation.
17613	
17614	required for left-right (l-r) asymmetry determination of organ systems in mammals. may play a role in endometrial bleeding.
17615	
17616	intracellular transport of retinol.
17617	
17618	
17619	this is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
17620	atp-dependent rna helicase involved in 40s ribosomal subunit biogenesis. required for the processing and cleavage of 35s pre-rrna at sites a0, a1, and a2, leading to mature 18s rrna.
17621	
17622	receptor for udp-glucose and other udp-sugar coupled to g-proteins. not activated by atp, adp, utp or atp.
17623	
17624	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
17625	may function as a tumor suppressor, inhibiting colony formation, causing g1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
17626	transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. binds to the consensus sequence 5@#$%&-agatag-3@#$%&.
17627	
17628	rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. it may also have a role in the development of malignancy and the growth progression of some tumors.
17629	essential component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. seems to control the nucleotide-dependent binding of mitochondrial hsp70 to substrate proteins.
17630	may be involved in transcriptional regulation.
17631	
17632	putative target protein of adp-ribosylation factor.
17633	
17634	
17635	catalyzes the adenylation by atp of the carboxyl- terminal glycine of this.
17636	
17637	may be involved in transcriptional regulation. plays a role during development and organogenesis as well as in the function of the adult central nervous system (by similarity).
17638	may act as a specific coactivator for the mammalian tefs (by similarity).
17639	histone h4, along with histone h3, plays a central role in nucleosome formation.
17640	seems to play an important role in erythropoiesis.
17641	
17642	
17643	
17644	interacts with naf1 and inhibits tnf-induced nf-kappa-b- dependent gene expression by interfering with an rip- or traf2- mediated transactivation signal. inhibitor of programmed cell death. has a role in the function of the lymphoid system and may contribute to the in vivo effects of tnf (by similarity). has deubiquitinating activity that is directed towards lys-48 or lys- 63-linked polyubiquitin chains.
17645	
17646	
17647	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
17648	
17649	probably involved in the control of the cell cycle. interacts with d-type g1 cyclins.
17650	
17651	
17652	mediates the splicing of pre-mrna by binding to the stem loop i region of u1-snrna.
17653	
17654	
17655	
17656	inhibits vascular endothelial growth and angiogenesis (in vitro).
17657	
17658	part of the ap-3 complex, an adaptor-related complex which is not clathrin-associated. the complex is associated with the golgi region as well as more peripheral structures. it facilitates the budding of vesicles from the golgi membrane and may be directly involved in trafficking to lysosomes.
17659	putative atp-dependent protease.
17660	
17661	
17662	
17663	
17664	
17665	degrades ubl1 and smt3h2 conjugates and releases the monomers. acts on sumoylated pml.
17666	part of a complex implicated in the control of actin polymerization in cells.
17667	
17668	
17669	isoform gch-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.
17670	
17671	may play an integral structural role in elastic-fiber architectural organization and/or assembly.
17672	kinase that can phosphorylate various inositol polyphosphate such as ins(3,4,5,6)p4 or ins(1,3,4)p3. phosphorylates ins(3,4,5,6)p4 at position 1 to form ins(1,3,4,5,6)p5. this reaction is thought to have regulatory importance, since ins(3,4,5,6)p4 is an inhibitor of plasma membrane ca(2+)-activated cl(-) channels, while ins(1,3,4,5,6)p5 is not. also phosphorylates ins(1,3,4)p3 on o-5 and o-6 to form ins(1,3,4,6)p4, an essential molecule in the hexakisphosphate (insp6) pathway. also acts as an inositol polyphosphate phosphatase that dephosphorylate ins(1,3,4,5)p4 and ins(1,3,4,6)p4 to ins(1,3,4)p3, and ins(1,3,4,5,6)p5 to ins(3,4,5,6)p4. may also act as an isomerase that interconverts the inositol tetraphosphate isomers ins(1,3,4,5)p4 and ins(1,3,4,6)p4 in the presence of adp and magnesium. probably acts as the rate-limiting enzyme of the insp6 pathway. modifies tnf-alpha-induced apoptosis by interfering with the activation of tnfrsf1a-associated death domain.
17673	
17674	probable transcriptional regulator involved in developmental processes. could be required for specification of paraxial mesoderm structures during gastrulation (by similarity).
17675	
17676	may play an important role in cell fate determination during lung development and in spermatogenesis (by similarity).
17677	
17678	may be involved in transcriptional regulation.
17679	involved in redox regulation of the cell. reduces peroxides with reducing equivalents provided through the thioredoxin system. it is not able to receive electrons from glutaredoxin. may play an important role in eliminating peroxides generated during metabolism. might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of h(2)o(2).
17680	produces atp from adp in the presence of a proton gradient across the membrane.
17681	cytochromes p450 are a group of heme-thiolate monooxygenases. this enzyme requires molecular oxygen and nadph for the omega-hydroxylation of ltb4, a potent chemoattractant for polymorphonuclear leukocytes.
17682	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
17683	
17684	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems. the g(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli.
17685	
17686	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
17687	
17688	dorsalizing factor. key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing tgf-beta family bone morphogenetic proteins (bmps) and sequestering them in latent complexes.
17689	stimulates specifically the gtpase activity of ypt6.
17690	
17691	
17692	
17693	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
17694	
17695	may be an organic anion pump relevant to cellular detoxification.
17696	binds preferentially single-stranded dna and unwinds double stranded dna.
17697	
17698	associates with the t-cell antigen receptor zeta chain (cd3z). plays a role in lymphocyte activation.
17699	
17700	
17701	
17702	
17703	
17704	
17705	
17706	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
17707	may be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. may also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
17708	may be involved in transcriptional regulation.
17709	
17710	
17711	
17712	involved in the presentation of foreign antigens to the immune system.
17713	
17714	tumor-associated antigen.
17715	
17716	
17717	
17718	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
17719	
17720	
17721	
17722	may play a role in the response to environmental stress. appears to act upstream of the jun n-terminal pathway.
17723	
17724	
17725	
17726	
17727	
17728	inhibitor of bone morphogenetic protein (bmp) function, it may regulate bmp responsiveness of osteoblasts and chondrocytes.
17729	
17730	
17731	
17732	
17733	
17734	
17735	
17736	molecular chaperone. has atpase activity (by similarity).
17737	osteostatin is a potent inhibitor of osteoclastic bone resorption.
17738	
17739	
17740	
17741	
17742	
17743	
17744	
17745	has an atp-independent isopeptidase activity, cleaving at the c-terminus of the ubiquitin moiety. in vitro, isoform 2, but not isoform 3, shows deubiquitinating activity.
17746	receptor for grf, coupled to g proteins which activate adenylyl cyclase. stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.
17747	
17748	
17749	involved in the regulation of growth and apoptosis. mediates activation of stress-responsive mtk1/mekk4 mapkkk.
17750	communication between transverse-tubules and sarcoplasmic reticulum. contraction of skeletal muscle is triggered by release of calcium ions from sr following depolarization of t-tubules.
17751	could function as a cell-adhesion protein. acts as a tumor suppressor. required for correct morphogenesis.
17752	
17753	
17754	
17755	dna-binding protein that binds to the 5@#$%&-aata[ct]-3@#$%& core sequence. probably acts as a transcription regulator. represses the cytomegalovirus enhancer. overexpression leads to induction of smooth muscle marker genes, suggesting that it may act as a regulator of smooth muscle cell differentiation and proliferation. may be involved in lipid stores.
17756	
17757	
17758	
17759	
17760	
17761	
17762	
17763	
17764	
17765	
17766	
17767	
17768	mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.
17769	
17770	plays a central role in dna repair by facilitating cellular response to dna repair. required for appropriate cell cycle arrests after ionizing irradiation in both the s-phase and the g2 phase of the cell cycle. involved in transcriptional regulation of p21 in response to dna damage. required for fancd2 targeting to sites of dna damage. may function as a transcriptional regulator. mediates e2-dependent ubiquitination (by similarity).
17771	
17772	type i collagen is a member of group i collagen (fibrillar forming collagen).
17773	
17774	atp-dependent specificity component of the clp protease. it directs the protease to specific substrates. can perform chaperone functions in the absence of clpp (by similarity).
17775	
17776	
17777	
17778	
17779	
17780	
17781	major keratinocyte cell envelope protein.
17782	sequence-specific rna-binding protein that regulates translation and mrna stability by binding the 3@#$%& untranslated regions (utrs) of mrna targets. may be required to support proliferation and self-renewal of stem cells (by similarity).
17783	
17784	component of a putative tumor-recognition complex. involved in the function of nk cells.
17785	could be involved in the control of plant growth and development. phosphorylates two ribosomal proteins, p14 and p16.
17786	
17787	
17788	
17789	
17790	
17791	forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
17792	initiates the extrinsic pathway of blood coagulation. serine protease that circulates in the blood in a zymogen form. factor vii is converted to factor viia by factor xa, factor xiia, factor ixa, or thrombin by minor proteolysis. in the presence of tissue factor and calcium ions, factor viia then converts factor x to factor xa by limited proteolysis. factor viia will also convert factor ix to factor ixa in the presence of tissue factor and calcium.
17793	
17794	
17795	catalyzes the covalent attachment of ubiquitin to other proteins. in association with the e3 enzyme bre1 and lge1, it plays a role in transcription regulation by catalyzing the monoubiquitination of lys-123 of histone h2b leading to the trimethylation of histone h3 lys-4 by compass, the localization of the paf1 complex to the chromatin and the silencing of telomeric- associated genes. in association with the e3 enzyme rad18, it catalyzes the monoubiquitination of pol30 lys-164, involved in postreplication repair of uv-damaged dna. the ubc2-rad18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine. in association with the e3 enzyme ubr1, is involved in n-end rule-dependent protein degradation. also involved in sporulation.
17796	
17797	carries out a dual function: signal transduction and activation of transcription. binds to the gas element and activates prl-induced transcription.
17798	transcription factor which binds specifically to the mef2 element present in the regulatory regions of many muscle- specific genes. activates transcription via this element. may be involved in muscle-specific and/or growth factor-related transcription.
17799	
17800	may be involved in transcriptional regulation.
17801	transcription factor that binds gc and gt boxes in the d1a, d2 and d3 dopamine receptor promoters and displaces sp1 and sp3 from these sequences. it modulates dopaminergic transmission in the brain by repressing or activating transcription from several different promoters depending on cellular context.
17802	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
17803	
17804	
17805	somewhat implicated in the biogenesis of peroxisomes.
17806	promotes the exchange of ras-bound gdp by gtp.
17807	
17808	binds the sequence 5@#$%&-atcaatcaa-3@#$%&. acts as a transcriptional activator of pf4 in complex with meis1. converted into a potent transcriptional activator by the (1;19) translocation. may have a role in steroidogenesis and, subsequently, sexual development and differentiation.
17809	
17810	
17811	
17812	
17813	
17814	
17815	regulatory subunit of the cyclin-dependent kinase pair (cdk9/cyclin t) complex, also called positive transcription elongation factor b (p-tefb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the ctd (carboxy-terminal domain) of the large subunit of rna polymerase ii (rnap ii). does not bind efficiently to the transactivation domain of the hiv-1 nuclear transcriptional activator, tat.
17816	
17817	inhibitor of protein-phosphatase 1.
17818	
17819	
17820	the glycine cleavage system catalyzes the degradation of glycine.
17821	regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. serves as a target for the yopt cysteine peptidase from yersinia pestis, vector of the plague, and yersinia pseudotuberculosis, which causes gastrointestinal disorders.
17822	essential component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. seems to control the nucleotide-dependent binding of mitochondrial hsp70 to substrate proteins.
17823	recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. involved in the degradation of cyclin e, notch1 released notch intracellular domain (nicd), and probably psen1.
17824	
17825	sodium-ion dependent, high affinity carnitine transporter. involved in the active cellular uptake of carnitine. transports one sodium ion with one molecule of carnitine. also transports organic cations such as tetraethylammonium (tea) without the involvement of sodium. also relative uptake activity ratio of carnitine to tea is 11.3.
17826	
17827	involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. substrates include pomc, renin, enkephalin, dynorphin, somatostatin and insulin.
17828	
17829	contactins mediate cell surface interactions during nervous system development. has some neurite outgrowth-promoting activity (by similarity).
17830	
17831	histone h3, along with histone h4, plays a central role in nucleosome formation.
17832	may play an important role in the apoptotic process, possibly within the modified cytoskeleton. its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.
17833	
17834	
17835	
17836	
17837	redirects newly synthesized mhc class i heavy chains via the sec61 translocon to the cytosol where they undergo proteasome- dependent destruction. in consequence, infected cells are masked for immune recognition by cytotoxic t-lymphocytes.
17838	insulin-regulated facilitative glucose transporter. binds cytochalasin b in a glucose-inhibitable manner. seems to be a dual-specific sugar transporter as it is inhibitable by fructose (by similarity).
17839	the function of brain maps is essentially unknown. phosphorylated map1b may play a role in the cytoskeletal changes that accompany neurite extension. possibly map1b binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules.
17840	adf augments the expression of the interleukin-2 receptor tac (il2r/p55).
17841	binds medium- and long-chain acyl-coa esters with very high affinity and may function as an intracellular carrier of acyl-coa esters. it is also able to displace diazepam from the benzodiazepine (bzd) recognition site located on the gaba type a receptor. it is therefore possible that this protein also acts as a neuropeptide to modulate the action of the gaba receptor.
17842	
17843	
17844	
17845	
17846	functions in mitochondrial and peroxisomal division probably by regulating membrane fission. enzyme hydrolyzing gtp that oligomerizes to form ring-like structures and is able to remodel membranes. may also play a role on organelles of the secretory pathway.
17847	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
17848	required for membrane traffic to the vacuole.
17849	may play an integral structural role in elastic-fiber architectural organization and/or assembly.
17850	transcription factor capable of interacting with purine rich repeats (ga repeats). necessary for the expression of the adenovirus e4 gene.
17851	cooperates with cdc6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate dna replication. binds dna in a sequence-, strand-, and conformation-independent manner. potential oncogene.
17852	may be involved in transcriptional regulation.
17853	may be involved in transcriptional regulation.
17854	thiolesterase that catalyzes the hydrolysis of s-d- lactoyl-glutathione to form glutathione and d-lactic acid.
17855	
17856	
17857	
17858	
17859	
17860	may be involved in transcriptional regulation.
17861	udpgt is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. the major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (dht) > androstane-3alpha,17beta-diol (3alpha-diol) > testosterone > androsterone (adt).
17862	catalyzes the covalent attachment of ubiquitin to other proteins.
17863	
17864	
17865	stimulates specifically the gtpase activity of ypt6.
17866	
17867	required for intramitochondrial proteolysis. catalyzes the initial steps of protein degradation.
17868	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
17869	
17870	
17871	
17872	
17873	
17874	
17875	
17876	
17877	
17878	guanine nucleotide exchange factor that interacts with rhoa, but not with rac or cdc42. activates rhoa to promote cytoskeletal contraction and inhibit neurite outgrowth.
17879	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
17880	
17881	participates in the regulation of gene transcription. binds dna both in a non-specific manner and also specifically to recognizes the core sequence 5@#$%&-cac[ga]tg-3@#$%&. seems to activate the transcription of growth-related genes.
17882	required for protein transport from the er to the golgi complex.
17883	involved in pre-mrna splicing. is required together with atp and at least one other factor, for the first cleavage-ligation reaction. interacts directly with the pre-mrna.
17884	
17885	
17886	
17887	
17888	may be involved in transcriptional regulation.
17889	actin-binding protein involved in motile and morphological processes. inhibits actin polymerization, likely by sequestering g-actin. by capping the barbed ends of filaments, it also regulates motility. seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (by similarity).
17890	
17891	
17892	
17893	binds pre-mrna and nucleates the assembly of 40s hnrnp particles. single hnrpc tetramers bind 230-240 nucleotides. trimers of hnrpc tetramers bind 700 nucleotides. may play a role in the early steps of spliceosome assembly and pre-mrna splicing. interacts with poly-u tracts in the 3@#$%& or 5@#$%& untranslated regions of mrna and modulates the stability and the level of translation of bound mrna molecules.
17894	
17895	
17896	may be a controller of the mitotic cell cycle. involved in the blood cell development.
17897	subunit of atp-sensitive potassium channels (katp). can form cardiac and smooth muscle-type katp channels with kir6.2. kir6.2 forms the channel pore while sur2 is required for activation and regulation.
17898	
17899	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
17900	
17901	
17902	
17903	
17904	
17905	
17906	
17907	
17908	
17909	
17910	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
17911	
17912	
17913	
17914	
17915	
17916	
17917	
17918	
17919	
17920	
17921	required for protein transport from the er to the golgi complex.
17922	involved in matrix assembly (by similarity).
17923	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
17924	
17925	
17926	
17927	
17928	involved in calcium binding and microtubule stabilization.
17929	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. may be implicated in the folding, transport, and assembly of proteins. may play an important role in the regulation of pre-mrna splicing.
17930	growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. binds to the vegfr1/flt-1 and vegfr2/kdr receptors, heparan sulfate and heparin. neuropilin-1 binds isoforms vegf-165 and vegf-145.
17931	activates cdc42, a member of the ras-like family of rho- and rac proteins, by exchanging bound gdp for free gtp. plays a role in regulating the actin cytoskeleton and cell shape.
17932	
17933	transports l-glutamate and also l- and d-aspartate. seems to act as a symport by cotransporting sodium.
17934	this is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
17935	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
17936	gtpase activator for the rho-type gtpases by converting them to an inactive gdp-bound state (by similarity).
17937	component of the cytoplasmic fibrils of the nuclear pore complex implicated in nuclear protein import. its n-terminus is involved in activation of oncogenic kinases.
17938	
17939	
17940	
17941	has acyl-coa ligase activity for long-chain and very- long-chain fatty acids. does not exhibit fatty acid transport activity (by similarity).
17942	this small ubiquitous enzyme is essential for maintenance and cell growth.
17943	stabilizer subunit of the dolichol-phosphate-mannose synthase complex.
17944	
17945	component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. three proteases; ndl, gd and snk process easter to create active easter. active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the tl receptor in the ventral region of the embryo. promotes heterophilic cellular adhesion. spz c-106 in the hemolymph controls expression of the antifungal peptide drosomycin (drs) by acting as a ligand of tl and inducing an intracellular signaling pathway.
17946	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes and then transfers it to substrates (by similarity).
17947	may play a role in microtubule-mediated transport or vesicle function.
17948	possible adhesion molecule with a role in early hematopoiesis by mediating attachment to stromal cells. influences the survival and/or proliferation of b-cell precursors. binding to cells requires mn(2+) (by similarity).
17949	udpgt is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
17950	promotes the exchange of ras-bound gdp by gtp.
17951	
17952	
17953	the protein is required for polarized cell growth.
17954	transcriptional activator. binds to fat body-specific enhancers of alcohol dehydrogenase (adh) and yolk protein genes. bbf-2 may play a role in fat body gene expression. it binds the consensus sequence 5@#$%&-t[ac]nacgtan[tg]c-3@#$%&.
17955	
17956	
17957	
17958	
17959	specifically hydroxylates an asp or asn residue in certain epidermal growth factor-like (egf) domains of a number of proteins.
17960	it may catalyze the formation of the neuac-alpha-2,3- gal-beta-1,3-galnac- or neuac-alpha-2,3-gal-beta-1,3-glcnac- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. it may be involved in the biosynthesis of the sialyl lewis x determinant.
17961	
17962	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
17963	
17964	
17965	
17966	
17967	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
17968	
17969	promotes guanine-nucleotide exchange on arf1 and arf5. promotes the activation of arf through replacement of gdp with gtp.
17970	may be involved in transcriptional regulation.
17971	may be involved in transcriptional regulation.
17972	
17973	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
17974	
17975	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
17976	probably plays a role in facilitating the assembly of multimeric protein complexes inside the er.
17977	
17978	stimulates the dissociation of gdp from the ras-related rala and ralb gtpases which allows gtp binding and activation of the gtpases. interacts and acts as an effector molecule for r-ras, h-ras, k-ras, and rap.
17979	
17980	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
17981	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
17982	plays a role in biomineralization. seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. thought to play a major role in the structural organization and mineralization of developing enamel.
17983	
17984	
17985	inhibits the binding of prostaglandin f2-alpha (pgf2- alpha) to its specific fp receptor, by decreasing the receptor number rather than the affinity constant. functional coupling with the prostaglandin f2-alpha receptor seems to occur.
17986	involved in the inactivation of map kinases. has a specificity for the mapk11/mapk12/mapk13/mapk14 subfamily.
17987	cysteine protease cleaving the c-terminal amino acid of atg8 to reveal a c-terminal glycine. atg8 ubiquitin-like activity requires the exposure of the glycine at the c-terminus for its conjugation to phosphatidylethanolamine and its insertion to membranes, which is necessary for autophagy. inhibited by n- ethylmaleimide.
17988	
17989	
17990	
17991	
17992	
17993	
17994	accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. all three isoforms alter the functional properties of kv1.4 and kv1.5. isoform kvb1.2 has no effect on kv1.1, kv1.2 or kv2.1.
17995	
17996	
17997	
17998	has chemotactic activity for neutrophils. may play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. in vitro, the processed form gro-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
17999	general transcription factor. btf3 can form a stable complex with rna polymerase ii. required for the initiation of transcription.
18000	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling. phosphorylates ctnnb1 on ser-45.
18001	pp2a can modulate the activity of phosphorylase b kinase casein kinase 2, mitogen-stimulated s6 kinase, and map-2 kinase. can dephosphorylate sv40 large t antigen and p53. dephosphorylates sv40 large t antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. the c subunit was most active, followed by the ac form, which was more active than the abc form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. dephosphorylation by the ac form, but not c or abc form is inhibited by small t antigen.
18002	may have an important role in regulating the access of circulating igfs to the tissues.
18003	responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain.
18004	
18005	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
18006	jana and janb regulate somatic sex differentiation.
18007	
18008	
18009	
18010	
18011	
18012	
18013	endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). may also play a role in neovascularization or angiogenesis. hydrolyzes collagen type iv, laminin, nidogen, nascin-c isoform, fibronectin, and type i gelatin.
18014	
18015	
18016	cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
18017	transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. crucial in the maintenance of the thyroid differentiation phenotype. may play a role in lung development and surfactant homeostasis.
18018	
18019	could have a regulatory function in meiosis.
18020	
18021	
18022	
18023	
18024	
18025	
18026	
18027	
18028	mediates the binding and degradation of acetylated low density lipoprotein (ac-ldl). mediates heterophilic interactions, suggesting a function as adhesion protein (by similarity).
18029	
18030	
18031	
18032	
18033	required for vesicular transport between the endoplasmic reticulum and the golgi apparatus.
18034	
18035	transcription factor required for gene expression specific to photoreceptor cells.
18036	potent transcriptional repressor that binds to the h1 element of the ets2 promoter. may regulate other genes involved in cellular proliferation.
18037	
18038	plays a general role in the hierarchies of gene expression leading to metamorphosis.
18039	plays a general role in the hierarchies of gene expression leading to metamorphosis.
18040	
18041	
18042	
18043	
18044	may be involved in the pdh (pyruvate dehydrogenase complex) bypass.
18045	
18046	not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
18047	
18048	
18049	
18050	
18051	
18052	
18053	
18054	receptor for tnfsf6/faslg. the adapter molecule fadd recruits caspase-8 to the activated receptor. the resulting death- inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. fas- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature t-cells, or both. the secreted isoforms 2 to 6 block apoptosis (in vitro).
18055	may regulate the transcription of specific genes during normal development. may play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. implicated in the transduction of shh signal (by similarity).
18056	
18057	
18058	
18059	may be involved in transcriptional regulation.
18060	component of the anaphase promoting complex/cyclosome (apc/c), a cell cycle-regulated e3 ubiquitin ligase that controls progression through mitosis and the g1 phase of the cell cycle.
18061	
18062	probably involved in connections of major cytoskeletal structures to the plasma membrane.
18063	
18064	
18065	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
18066	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
18067	
18068	
18069	
18070	
18071	
18072	
18073	
18074	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
18075	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
18076	
18077	
18078	
18079	
18080	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells. cadherin 23 may function as hair bundle organizer perhaps by cross-linking the stereocilia (by similarity).
18081	
18082	
18083	
18084	
18085	
18086	could function as a cell-adhesion protein. acts as a tumor suppressor. required for correct morphogenesis.
18087	
18088	
18089	
18090	
18091	has e3 ubiquitin ligase activity. the ccr4-not complex functions as general transcription regulation complex.
18092	
18093	
18094	
18095	appears to play a role in cell sterol metabolism. it may function to protect cells from over-accumulation of cholesterol.
18096	
18097	
18098	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
18099	transcription factor that binds to and transactivates the tshb promoter. binds to a minimal dna-binding sequence 5@#$%&- [tc][ag][ag]tta[tc][ag]-3@#$%&.
18100	
18101	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
18102	necessary for efficient rna polymerase ii transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by s-ii allows the resumption of elongation from the new 3@#$%&terminus.
18103	
18104	
18105	
18106	
18107	
18108	
18109	
18110	the major proteolytic product p15 bid allows the release of cytochrome c (by similarity). isoform 1, isoform 2 and isoform 4 induce ice-like proteases and apoptosis. isoform 3 does not induce apoptosis. counters the protective effect of bcl-2.
18111	
18112	may play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.
18113	
18114	
18115	
18116	
18117	
18118	
18119	regulatory light chain of myosin. does not bind calcium.
18120	
18121	deubiquitinating enzyme.
18122	
18123	protection of cells from complement-mediated damage (by similarity).
18124	may play a role in neuron-specific rna processing.
18125	protein tyrosine phosphatase which stimulates progression from g1 into s phase during mitosis. promotes tumors. inhibits geranylgeranyl transferase type ii activity by blocking the association between rabggta and rabggtb.
18126	
18127	
18128	associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. it may function in the assembly and/or transport of ribosome.
18129	
18130	
18131	
18132	
18133	
18134	has greatest activity toward short branched chain acyl- coa derivative such as (s)-2-methylbutyryl-coa, isobutyryl-coa, and 2-methylhexanoyl-coa as well as toward short straight chain acyl-coas such as butyryl-coa and hexanoyl-coa. can use valproyl- coa as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent.
18135	may act as a dnase and a rnase (potential).
18136	
18137	
18138	the beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating g protein inhibition and controlling the alpha-1 subunit membrane targeting.
18139	may be involved in transcriptional regulation.
18140	
18141	
18142	
18143	acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin g. may prevent elastase-mediated damage to oral and possibly other mucosal tissues.
18144	probably involved in the organization of the actin cytoskeleton. may act downstream of cdc42 to induce actin filament assembly leading to cell shape changes. induces pseudopodia formation, when overexpressed in fibroblasts.
18145	
18146	binds and activates the enhancer (delta-a element) of the cd3-delta gene. functions in the specification and the maturation of the t-lymphocyte. also interacts with a critical control element in the tdt (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of b- and t-cell development.
18147	
18148	
18149	dimethylates a single guanine residue at position 26 of most trnas using s-adenosyl-l-methionine as donor of the methyl groups. required for the modification of both mitochondrial and cytoplasmic trnas.
18150	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking among different compartments. modulates vesicle budding and uncoating within the golgi complex. deactivation induces the redistribution of the entire golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. in its gtp-bound form, its triggers the association with coat proteins with the golgi membrane. the hydrolysis of arf1-bound gtp, which is mediated by arfgaps proteins, is required for dissociation of coat proteins from golgi membranes and vesicles.
18151	
18152	catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. has little activity towards prostaglandins a1 and e1.
18153	required maternally for proper expression of other homeotic genes involved in pattern formation, such as ubx.
18154	may modulate calcium-mediated postsynaptic signals (by similarity).
18155	
18156	transporter for alanine, serine, cysteine, and threonine. exhibits sodium dependence.
18157	regulatory light chain of myosin. does not bind calcium.
18158	acts as a transcriptional repressor for zinc finger transcription factors egr1 and egr2 (by similarity).
18159	
18160	has a dehydrogenase activity on palmitoyl-coa (c16:0) and stearoyl-coa (c18:0). it is three times more active on palmitoyl-coa then on stearoyl-coa. has little activity on octanoyl-coa (c8:0), butyryl-coa (c4:0) or isovaleryl-coa (5:0).
18161	required for protein transport from the er to the golgi complex.
18162	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
18163	
18164	
18165	
18166	
18167	stimulates the gtpase activity of ras. nf1 shows greater affinity for ras gap, but lower specific activity. may be a regulator of ras activity.
18168	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
18169	
18170	
18171	required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.
18172	involved in the maintenance of proper dna topology and chromosome integrity via annealing of single-stranded dna breaks. modulates dna polymerase delta during replication or replication- associated repair. may function as a modulator for sgs1 when dna is damaged.
18173	may be involved in transcriptional regulation.
18174	
18175	
18176	
18177	
18178	binds the telomeric double-stranded ttaggg repeat and negatively regulates telomere length. involved in the regulation of the mitotic spindle.
18179	acts as decoy receptor for rankl and thereby neutralizes its function in osteoclastogenesis. inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. bone homeostasis seems to depend on the local rankl/opg ratio. may also play a role in preventing arterial calcification. may act as decoy receptor for trail and protect against apoptosis. trail binding blocks the inhibition of osteoclastogenesis.
18180	may serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins (by similarity).
18181	
18182	
18183	
18184	
18185	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
18186	
18187	
18188	
18189	interferes with cbl-mediated down-regulation and degradation of receptor-type tyrosine kinases. promotes accumulation of activated target receptors, such as t-cell receptors, egfr and pdgfrb, on the cell surface.
18190	actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells.
18191	required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
18192	membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. it plays a role in fatty-acid desaturation and is also involved in several steps of the sterol biosynthesis pathway, particularly in the 4- demethylation of the 4,4@#$%&-dimethyl zymosterol.
18193	essential for the control of the cell cycle at the g1/s (start) transition.
18194	minor apolipoprotein that associates with ldl. inhibits cholesteryl ester transfer protein (cetp) activity and appears to be an important regulator of cholesterol transport. also associates to a lesser degree with vldl, apo-ai and apo-aii.
18195	receptor for mica, micb, ulbp1, ulbp2, ulbp3 (ulbp2>ulbp1>ulbp3) and ulbp4. plays a role as a receptor for the recognition of mhc class i hla-e molecules by nk cells and some cytotoxic t-cells. involved in the immune surveillance exerted by t- and b-lymphocytes.
18196	
18197	may be involved in vesicular trafficking and neurotransmitter release (by similarity).
18198	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
18199	
18200	
18201	
18202	
18203	
18204	
18205	may be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. may play a role in cell migration (by similarity).
18206	
18207	exhibits outward rectification in a physiological k(+) gradient and mild inward rectification in symmetrical k(+) conditions.
18208	involved in the biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (moad).
18209	
18210	required for membrane traffic to the vacuole.
18211	
18212	involved in maintaining the transcriptionally repressive state of genes. modifies chromatin, rendering it heritably changed in its expressibility (by similarity). regulator of cellular lifespan by maintaining the repression of cdkn2a, but not by inducing telomerase activity.
18213	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
18214	
18215	
18216	
18217	
18218	possible transcription factor.
18219	may be involved in transcriptional regulation.
18220	
18221	
18222	molecular chaperone. has atpase activity (by similarity).
18223	
18224	
18225	performs a specialized role during sperm development and maturation.
18226	
18227	
18228	may be involved in transcriptional regulation.
18229	
18230	
18231	isoform b has an accelerated gef-independent gdp/gtp exchange and an impaired gtp hydrolysis, which is restored partially by gtpase-activating proteins. it is able to bind to the gtpase-binding domain of pak but not full-length pak in a gtp- dependent manner, suggesting that the insertion does not completely abolish effector interaction.
18232	
18233	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein (by similarity).
18234	may mediate uptake of degraded synaptic material which could play an important role in synaptic remodeling. can mediate the neuronal and glial uptake of the snake venom toxin taipoxin (by similarity).
18235	
18236	
18237	
18238	
18239	transcriptional repressor.
18240	
18241	
18242	
18243	
18244	
18245	
18246	
18247	
18248	
18249	
18250	
18251	
18252	
18253	
18254	
18255	may act as a mediator of stress-activated signals.
18256	
18257	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
18258	
18259	
18260	
18261	
18262	
18263	
18264	
18265	
18266	
18267	
18268	
18269	
18270	
18271	
18272	
18273	
18274	
18275	
18276	
18277	
18278	
18279	
18280	
18281	may be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors (potential).
18282	possibly acts as a transcriptional regulatory factor.
18283	regulates myosin phosphatase activity. augments ca(2+) sensitivity of the contractile apparatus.
18284	facilitative glucose transporter (by similarity).
18285	
18286	
18287	
18288	cell autonomous negative regulator of lin-12/notch- mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. may function as part of an e3 complex to target the intracellular domains of lin-12/notch proteins for ubiquitin-dependent degradation.
18289	
18290	necessary for efficient rna polymerase ii transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by s-ii allows the resumption of elongation from the new 3@#$%&terminus.
18291	
18292	
18293	plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine.
18294	plays a role in photoreceptor morphogenesis in the retina. may maintain cell polarization and adhesion.
18295	
18296	may be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium atpase.
18297	
18298	can degrade casein. could play a role in tissues homeostasis and repair.
18299	
18300	probable adapter protein involved in signaling pathways. interacts with the sh2 and sh3 domains of various signaling proteins when it is phosphorylated. may promotes fyn activation, possibly by disrupting intramolecular sh3-dependent interactions (by similarity).
18301	
18302	inhibits nf-kappa-b activation. may participate in a regulatory mechanism that coordinates cellular responses controlled by nf-kappa-b transcription factor. may be a component of the inflammasome, a protein complex which also includes pycard, nalp2 and casp1 and whose function would be the activation of proinflammatory caspases.
18303	
18304	
18305	
18306	probably involved in connections of major cytoskeletal structures to the plasma membrane. high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (by similarity).
18307	
18308	
18309	
18310	necessary for early peroxisomal biogenesis. acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (pmps). binds and stabilizes newly synthesized pmps in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein pex3. excludes cdkn2a from the nucleus and prevents its interaction with mdm2, which results in active degradation of tp53.
18311	plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. this phosphodiesterase has high affinity for camp and may be involved in specific signaling in the thyroid gland.
18312	inhibits the transcriptional activity of spi1 in a dose- dependent manner (by similarity).
18313	
18314	
18315	katacalcin is a potent plasma calcium-lowering peptide.
18316	may be involved in several stages of intracellular trafficking. overexpression of snx15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the tgn.
18317	
18318	may play an important role during the embryonic development and differentiation of the central nervous system.
18319	probable transcription factor. may play an important role in recruitment of elf4 into pml nuclear bodies.
18320	
18321	transcription regulator that acts as a key regulator of lineage commitment of immature t-cell precursors. necessary and sufficient for commitment of cd4 lineage, while its absence causes cd8 commitment. development of immature t-cell precursors (thymocytes) to either the cd4 helper or cd8 killer t-cell lineages correlates precisely with their t-cell receptor specificity for major histocompatibility complex class ii or class i molecules, respectively. transcriptional repressor of the collagen col1a1 and col1a2 genes. may also function as a repressor of fibronectin and possibly other extracellular matrix genes (by similarity).
18322	not known. may be involved in the synthesis of the sugar donor dol-p-man which is required in the synthesis of n-linked and o-linked oligosaccharides and for that of gpi anchors (by similarity).
18323	plays a role in the import of cytosolically synthesized preproteins into mitochondria. binds the mature portion of precursor proteins. interacts with cellular components, and possesses weak atpase activity. may be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.
18324	may function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.
18325	
18326	
18327	e3 ubiquitin ligase protein that mediates monoubiquitination of lys-119 of histone h2a, thereby playing a central role in histone code and gene regulation. h2a lys-119 ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in x chromosome inactivation of female mammals. may be involved in the initiation of both imprinted and random x inactivation. essential component of the polycomb group (pcg) multiprotein prc1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including hox genes, throughout development. pcg prc1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. acts as the main e3 ubiquitin ligase on histone h2a of the prc1 complex, while ring1 and pcgf4/bmi1 may rather act as a modulator of rnf2/ring2 activity.
18328	associates with cd4 or cd8 and delivers costimulatory signals for the tcr/cd3 pathway.
18329	important for the overall degradation of proteins in lysosomes. essential for adult male and female fertility. may play a role in digestion.
18330	
18331	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
18332	
18333	
18334	receptor for interleukin-1 alpha (il-1a), beta (il-1b), and interleukin-1 receptor antagonist protein (il-1ra). binding to the agonist leads to the activation of nf-kappa-b. signaling involves formation of a ternary complex containing il1rap, tollip, myd88, and irak1 or irak2.
18335	
18336	
18337	component of the asymmetric unit membrane (aum); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. may play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through aum/cytoskeletal interactions (by similarity).
18338	
18339	
18340	activates transcription from class ii mhc promoters. recognizes x-boxes. mediates cooperative binding between rfx and nf-y. rfx binds the x1 box of mhc-ii promoters.
18341	
18342	
18343	catalyzes the covalent attachment of ubiquitin to other proteins. required for postreplication repair of uv-damaged dna. may be involved in neurite outgrowth.
18344	regulates the dimerization of homeodomain protein hnf-1- alpha and enhances its transcriptional activity.
18345	
18346	constitutes one of the e3 ubiquitin ligase proteins that mediate monoubiquitination of lys-119 of histone h2a, thereby playing a central role in histone code and gene regulation. h2a lys-119 ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in x chromosome inactivation of female mammals. essential component of the polycomb group (pcg) multiprotein prc1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including hox genes, throughout development. pcg prc1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. compared to rnf2/ring2, it does not have the main e3 ubiquitin ligase activity on histone h2a, and it may rather act as a modulator of rnf2/ring2 activity.
18347	
18348	
18349	
18350	
18351	
18352	transcriptional repressor.
18353	interacts with the viral protein-binding domain of the retinoblastoma protein.
18354	mrs4 suppresses a mitochondrial splice defect in the first intron of the cob gene. it may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). not essential.
18355	may be involved in transcriptional regulation.
18356	plays a role in tight junctions and adherens junctions.
18357	may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with gtp-binding proteins. essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. can interact with syntaxins 1, 2, and 3 but not syntaxin 4. may play a role in determining the specificity of intracellular fusion reactions.
18358	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
18359	
18360	
18361	
18362	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. utilizes a wide range of saturated fatty acids with a preference for c16-c18 unsaturated fatty acids (by similarity).
18363	may function as an adapter in striated muscle to couple protein kinase c-mediated signaling via its lim domains to the cytoskeleton.
18364	
18365	may be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. able to restore partial locomotion and axonal fasciculation to c.elegans unc-76 mutants in germ-line transformation experiments.
18366	
18367	
18368	links t-cell receptor activation signal to phospholipase c-gamma-1, grb-2 and phosphatidylinositol 3-kinase (by similarity).
18369	
18370	tfiia is a component of the transcription machinery of rna polymerase ii and plays an important role in transcriptional activation. interacts with tbp (the tata-binding protein).
18371	
18372	component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. also component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport. responsible for the localizing and stabilizing vault rna (vrna) association in the vault ribonucleoprotein particle (by similarity).
18373	receptor for extracellular adenine nucleotides such as atp and adp. in pancreatic islets, may mediate some of the effects of extracellular atp on insulin secretion.
18374	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
18375	may be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. may also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
18376	
18377	
18378	
18379	
18380	
18381	
18382	
18383	
18384	forms a water-specific channel. osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
18385	transcriptional modulator activated by tgf-beta and activin type 1 receptor kinase. smad2 is a receptor-regulated smad (r-smad). may act as a tumor suppressor in colorectal carcinoma.
18386	
18387	
18388	
18389	
18390	
18391	subunit of the splicing factor sf3a required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex.
18392	
18393	
18394	in cooperation with other chaperones, hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. these chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. they bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
18395	
18396	
18397	has a beta1,3-n-acetylglucosaminyltransferase activity for type 2 oligosaccharides.
18398	may play a role in neural crest cell migration into the third and fourth pharyngeal pouches.
18399	dephosphorylates proteins phosphorylated on ser, thr, and tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate.
18400	receptor for interleukin-2. this beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of il2.
18401	
18402	
18403	inhibitor of the slam self-association. acts by blocking recruitment of the sh2-domain-containing signal-transduction molecule shp-2 to a docking site in the slam cytoplasmic region.
18404	synthesis and degradation of fructose 2,6-bisphosphate.
18405	
18406	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
18407	
18408	
18409	
18410	
18411	
18412	
18413	
18414	probable dna-repair protein.
18415	
18416	
18417	required for protein transport from the er to the golgi complex.
18418	
18419	
18420	plays a major role in ketone body metabolism.
18421	type i collagen is a member of group i collagen (fibrillar forming collagen).
18422	
18423	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
18424	
18425	
18426	transports l-glutamate; the l-glutamate uptake is sodium- and voltage-dependent and chloride-independent. the eaat5- associated chloride conductance may participate in visual processing.
18427	
18428	
18429	
18430	
18431	
18432	endostatin potently inhibits endothelial cell proliferation and angiogenesis. may inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
18433	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. the n-terminus interacts with and regulates xpd whereas an intact c- terminus is required for a successful escape of rnap ii form the promoter.
18434	
18435	
18436	transcriptional regulator involved in development.
18437	
18438	
18439	
18440	
18441	
18442	
18443	
18444	
18445	
18446	mediates transcriptional repression by certain nuclear receptors. part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.
18447	
18448	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
18449	
18450	
18451	
18452	
18453	
18454	
18455	
18456	
18457	
18458	
18459	
18460	
18461	
18462	
18463	
18464	
18465	
18466	
18467	
18468	
18469	
18470	
18471	
18472	
18473	transcriptional repressor that binds to the promoter region of target genes. plays a role in the regulation of the cell cycle and of the wnt pathway. binds preferentially to the sequence 5@#$%&-ttcattcattca-3@#$%&. binding to the h1f0 promoter is enhanced by interaction with rb1. disrupts the interaction between dna and tcf4.
18474	
18475	non-catalytic subunit of the trna-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-trna. it cleaves pre-trna at the 5@#$%& and 3@#$%& splice sites to release the intron. the products are an intron and two trna half-molecules bearing 2@#$%&,3@#$%& cyclic phosphate and 5@#$%&-oh termini. there are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the trna body. the trna splicing endonuclease is also involved in mrna processing via its association with pre-mrna 3@#$%& end processing factors, establishing a link between pre-trna splicing and pre-mrna 3@#$%& end formation, suggesting that the endonuclease subunits function in multiple rna-processing events.
18476	may be involved in transcriptional regulation.
18477	
18478	may be involved in transcriptional regulation.
18479	thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (caz) which regulates neurotransmitter release. seems to act together with bsn. may recruit liprin-alpha proteins to the caz.
18480	
18481	
18482	
18483	
18484	
18485	
18486	
18487	
18488	
18489	
18490	
18491	
18492	
18493	may constitute a novel regulatory system for basal transcription. negatively regulates abt1 (by similarity).
18494	
18495	
18496	may have an important role in presynaptic function. may be involved in calcium-dependent neurotransmitter release at nerve endings (by similarity).
18497	
18498	
18499	
18500	essential for the development of polarized epithelia and for cell polarity associated with asymmetric cell division of neuroblasts during development. isoform p78 has an essential role in control of cell proliferation and differentiation during development and could act as tumor suppressor. isoform p217 has an accessory function in this respect.
18501	
18502	
18503	catalyzes the deimination of arginine residues of proteins (by similarity).
18504	may be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.
18505	
18506	
18507	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
18508	chemotactic for interleukin-activated t-cells but not unstimulated t-cells, neutrophils or monocytes. induces calcium release in activated t-cells. binds to cxcr3. may play an important role in cns diseases which involve t-cell recruitment. may play a role in skin immune responses.
18509	regulatory subunit of the calcium activated potassium kcnma1 (maxik) channel. modulates the calcium sensitivity and gating kinetics of kcnma1, thereby contributing to kcnma1 channel diversity. increases the apparent ca(2+)/voltage sensitivity of the kcnma1 channel. it also modifies kcnma1 channel kinetics and alters its pharmacological properties. it slows down the activation and the deactivation kinetics of the channel. acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to kcnma1. its presence is also a requirement for internal binding of the kcnma1 channel opener dehydrosoyasaponin i (dhs-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (e2). increases the binding activity of charybdotoxin (ctx) toxin to kcnma1 peptide blocker by increasing the ctx association rate and decreasing the dissociation rate.
18510	
18511	segment polarity protein, functions together with arm to transduce the wingless (wg) signal. acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
18512	fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
18513	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation by repressing transcription of myocyte enhancer mef2c. during muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (by similarity).
18514	has a high affinity for both camp and cgmp.
18515	involved in directing the movement of organelles along actin filaments (by similarity).
18516	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
18517	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna.
18518	
18519	synthesis and degradation of fructose 2,6-bisphosphate.
18520	receptor for acidic and basic fibroblast growth factors.
18521	binds mannose and n-acetylglucosamine in a calcium- dependent manner. is capable of host defense against pathogens, by activating the classical complement pathway independently of the antibody.
18522	
18523	transcriptional activator. binds to the sph motif of small nuclear rna (snrna) gene promoters.
18524	may be involved in several stages of intracellular trafficking. overexpression of snx15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the tgn.
18525	may contribute to the transparency and refractive index of the lens.
18526	
18527	
18528	may mediate the control of various cellular processes by insulin.
18529	
18530	probable transcription factor. may play an important role in recruitment of elf4 into pml nuclear bodies.
18531	
18532	
18533	
18534	
18535	
18536	
18537	
18538	binds to the 23s rrna (by similarity).
18539	precursors of the cornified envelope of the stratum corneum.
18540	likely to be an important mediator of ventricular differentiation during cardiac development.
18541	cell adhesion molecule with an important role in the development of the nervous system. involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. binds to axonin on neurons.
18542	
18543	type i collagen is a member of group i collagen (fibrillar forming collagen).
18544	type i collagen is a member of group i collagen (fibrillar forming collagen).
18545	
18546	
18547	
18548	has a higher affinity for cgmp than for camp.
18549	
18550	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters.
18551	receptor for interleukin 18 (il-18). binding to the agonist leads to the activation of nf-kappa-b.
18552	cellular role is not yet known.
18553	
18554	
18555	
18556	
18557	
18558	may have a role in promoting tumor progression. may block the tgfb1-enhanced cell growth.
18559	this enzyme catalyzes the hydrolysis of the n-terminal peptide bond of an n-acetylated peptide to generate an n- acetylated amino acid and a peptide with a free n-terminus. it preferentially cleaves off ac-ala, ac-met and ac-ser.
18560	required for the fusion of plasma membranes and early endosomes.
18561	
18562	
18563	may contribute to the alteration of neural cellular mechanisms (by similarity).
18564	
18565	involved in controlling the equilibrium between tubular and stacked structures in the golgi complex (by similarity). co- repressor targeting diverse transcription regulators. has dehydrogenase activity.
18566	not known, the c-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.
18567	factor that induces terminal differentiation of late- developing b-cells to immunoglobulin secreting cells.
18568	
18569	
18570	
18571	
18572	
18573	involved in transcription.
18574	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
18575	
18576	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
18577	sequence-specific dna-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. ap-2 factors bind to the consensus sequence 5@#$%&-gccnnnggc-3@#$%& and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. they also suppress a number of genes including mcam/muc18, c/ebp alpha and myc. ap-2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
18578	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
18579	
18580	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&. activates transcription of pf4 in complex with meis1.
18581	
18582	
18583	tp and tp5 may play a role in t-cell development and function. tp5 is an immunomodulating pentapeptide.
18584	transport of phosphorylated lysosomal enzymes from the golgi complex and the cell surface to lysosomes. lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low ph mediates the dissociation of the complex.
18585	in the intracellular compartments, may function as a channel or small molecule transporter.
18586	transcription factor that binds to gc box promoter elements. activates the transcription of these genes.
18587	gtpase-activating protein for rhoa, and perhaps for cdc42. may be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. acts a tumor suppressor in hepatocellular carcinoma cells.
18588	
18589	
18590	
18591	
18592	
18593	putative odorant receptor.
18594	
18595	major role in the synthesis of nucleoside triphosphates other than atp (by similarity).
18596	
18597	
18598	
18599	receptor for tnfsf11/rankl/trance/opgl; essential for rankl-mediated osteoclastogenesis. involved in the regulation of interactions between t-cells and dendritic cells.
18600	component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity.
18601	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
18602	possible role in vesicle-mediated transport. may be involved in proper membrane localization of rab gtpases.
18603	
18604	
18605	collagen type iv is specific for basement membranes. vital for embryonic development.
18606	
18607	a metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. may also play a role in the metabolism of the vasodilator bradykinin.
18608	
18609	
18610	
18611	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
18612	
18613	implicated in brca1-mediated tumor suppression. may, as part of the rna polymerase-2 holoenzyme, function in the cellular response to dna damage. in vitro, inhibits pre-mrna 3@#$%& cleavage.
18614	tumor suppressor. it blocks the growth, invasion, and metastatic properties of mammary tumors. as it does not undergo the s (stressed) to r (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
18615	
18616	
18617	
18618	
18619	
18620	
18621	
18622	
18623	
18624	
18625	
18626	
18627	
18628	
18629	may be involved in transcriptional regulation.
18630	
18631	
18632	
18633	
18634	
18635	
18636	
18637	
18638	
18639	
18640	
18641	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
18642	
18643	
18644	
18645	
18646	
18647	
18648	
18649	exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper b into subunit i (by similarity).
18650	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
18651	
18652	
18653	
18654	
18655	
18656	
18657	
18658	
18659	
18660	
18661	
18662	
18663	
18664	
18665	
18666	
18667	can act as repulsive axon guidance cues. may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (by similarity).
18668	
18669	
18670	
18671	
18672	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
18673	
18674	
18675	this multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. at the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. may therefore cause structural modifications of exofacial proteins. inside the cell, seems to form/rearrange disulfide bonds of nacent proteins. at high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. at low concentrations, facilitates aggregation (antichaperone activity). may be involved with other chaperones in the structural modification of the tg precursor in hormone biogenesis. also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein mttp.
18676	
18677	
18678	
18679	
18680	
18681	component of the circadian clock or downstream effector of clock function. exhibits a high amplitude circadian rhythm with maximal levels in early evening. in constant darkness or constant light, the amplitude of the rhythm decreases (by similarity).
18682	
18683	appears to mediate interactions between cells and the extracellular matrix. substrate-adhesion molecule that appears to inhibit cell migration. may play a role in supporting the growth of epithelial tumors.
18684	
18685	cd2 interacts with lymphocyte function-associated antigen (lfa-3) and cd48/bcm1 to mediate adhesion between t-cells and other cell types. cd2 is implicated in the triggering of t- cells, the cytoplasmic domain is implicated in the signaling function.
18686	cd2 interacts with lymphocyte function-associated antigen (lfa-3) and cd48/bcm1 to mediate adhesion between t-cells and other cell types. cd2 is implicated in the triggering of t- cells, the cytoplasmic domain is implicated in the signaling function.
18687	plasma membrane anion exchange protein of wide distribution. mediates at least a part of the cl(-)/hco3(-) exchange in cardiac myocytes. both bae3 and cae3 forms transport cl(-).
18688	
18689	
18690	
18691	binds to both dna and rna in vitro, with a stronger binding capacity for rna. may represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (by similarity).
18692	may be involved in protein transport (by similarity).
18693	
18694	it has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1. it is essential for growth or germination at 37 degrees celsius. may have a role in the heat shock response. involved in trna splicing and cell separation.
18695	
18696	receptor for glucocorticoids (gc). has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (gre) and as a modulator of other transcription factors. affects inflammatory responses, cellular proliferation and differentiation in target tissues. could act as a coactivator for stat5-dependent transcription upon growth hormone (gh) stimulation and could reveal an essential role of hepatic gr in the control of body growth.
18697	transcription factor that binds to the octamer motif (5@#$%&-atttgcat-3@#$%&). prime candidate for an early developmental control gene.
18698	
18699	
18700	
18701	in the process of mrna degradation, may play a role in mrna decapping.
18702	may be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. acts as a transcription activator/factor. could maintain the noradrenergic phenotype.
18703	may be involved in transcriptional regulation.
18704	
18705	
18706	
18707	
18708	inhibits gdp/gtp exchange reaction of rhob. interacts specifically with the gdp- and gtp-bound forms of post- translationally processed rhob and rhog proteins, both of which show a growth-regulated expression in mammalian cells. stimulates the release of the gdp-bound but not the gtp-bound rhob protein. also inhibits the gdp/gtp exchange of rhob but shows less ability to inhibit the dissociation of prebound gtp.
18709	
18710	
18711	
18712	may play a role in the molecular organization of synapses and neuronal cell signaling. could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. may induce enrichment of psd-95/sap90 at the plasma membrane.
18713	as an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
18714	possible role in transport between endoplasmic reticulum and golgi (by similarity).
18715	
18716	
18717	
18718	
18719	
18720	
18721	catalyzes the formation of fatty acid-cholesterol esters. plays a role in lipoprotein assembly and dietary cholesterol absorption. in addition to its acyltransferase activity, it may act as a ligase.
18722	
18723	central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. together with tom22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the tom40 translocation pore (by similarity).
18724	
18725	
18726	
18727	
18728	
18729	
18730	
18731	the glycine receptor is a neurotransmitter-gated ion channel. binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
18732	
18733	may be a mediator of localized cell proliferation. as a mitogen it may stimulate cell proliferation and/or angiogenesis.
18734	receptor for endothelin-1. mediates its action by association with g proteins that activate a phosphatidylinositol- calcium second messenger system. the rank order of binding affinities for et-a is: et1 > et2 >> et3.
18735	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
18736	
18737	
18738	
18739	
18740	
18741	
18742	transcriptional repressor.
18743	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
18744	may participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. may control the properties of the membrane associated cytoskeleton.
18745	
18746	may be involved in transcriptional regulation.
18747	receptor for the cytotoxic ligand tnfsf10/trail. the adapter molecule fadd recruits caspase-8 to the activated receptor. the resulting death-inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. promotes the activation of nf- kappa-b.
18748	
18749	may be involved in transcriptional regulation.
18750	
18751	inhibitor of wnt signaling pathway (potential).
18752	
18753	
18754	
18755	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
18756	stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. active in the presence of nad as cofactor but not in the presence of nadp.
18757	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes (by similarity).
18758	
18759	required for the binding of mrna to ribosomes. functions in close association with eif4-f and eif4-a. binds near the 5@#$%&- terminal cap of mrna in presence of eif-4f and atp. promotes the atpase activity and the atp-dependent rna unwinding activity of both eif4-a and eif4-f.
18760	
18761	component of the exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature nuclear complex. also associated with the gtpase ran. has a 3@#$%&-5@#$%& exonuclease activity.
18762	
18763	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb (by similarity).
18764	may play a role in notch signaling (by similarity).
18765	multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. may play an important role in development and differentiation. the function of yy1 as an activator or a repressor is specified by the presence of other proteins. for example it acts as a repressor in absence of adenovirus e1a protein but as an activator in its presence.
18766	
18767	deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. also phosphorylates anti-viral and anti-cancer nucleoside analogs.
18768	attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to na-k atpase, to the lymphocyte membrane protein gp85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. in skeletal muscle, isoform mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
18769	
18770	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
18771	activates erythroid-specific, globin gene expression.
18772	can activate specifically hydrolysis of gtp bound to rac1 and cdc42, but not rala. mediates atp-dependent transport of s-(2,4-dinitrophenyl)-glutathione (dnp-sg) and doxorubicin (dox) and is the major atp-dependent transporter of glutathione conjugates of electrophiles (gs-e) and dox in erythrocytes. can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon.
18773	calmodulin mediates the control of a large number of enzymes and other proteins by ca(2+). among the enzymes to be stimulated by the calmodulin-ca(2+) complex are a number of protein kinases and phosphatases.
18774	
18775	transcriptional activator. able to bind to two different type of dna binding sites. isoform foxj2.l behaves as a more potent transactivator than foxj2.s.
18776	
18777	
18778	
18779	may be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. may play a role in cell migration.
18780	essential subunit of n-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an asn-x-ser/thr consensus motif in nascent polypeptide chains.
18781	probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. may act by preventing binding of positively-activing ccaat factors to promoters. plays an essential role in lung maturation (by similarity).
18782	
18783	may participate in the obstruction of fluid outflow in the trabecular meshwork.
18784	
18785	plays a role in apical endocytosis/recycling.
18786	
18787	also acts as a tumor suppressor.
18788	
18789	
18790	
18791	may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes (by similarity).
18792	
18793	works in concert with the 5alpha/5beta-steroid reductases to convert steroid hormones into the 3alpha/5alpha and 3alpha/5beta-tetrahydrosteroids. catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5alpha-dht) to 5-alpha-androstane-3alpha,17beta-diol (3-alpha-diol).
18794	
18795	required for protein transport from the er to the golgi complex.
18796	
18797	
18798	may play a role in a erbb3-regulated signal transduction pathway. seems be involved in growth regulation. acts a corepressor of the androgen receptor (ar) and is regulated by the erbb3 ligand neuregulin-1/heregulin (hrg). inhibits transcription of some e2f1-regulated promoters, probably by recruiting histone acetylase (hat) activity. binds rna. associates with 28s, 18s and 5.8s mature rrnas, several rrna precursors and probably u3 small nucleolar rna. may be involved in regulation of intermediate and late steps of rrna processing. may be involved in ribosome assembly (by similarity). mediates cap-independent translation of specific viral iress (internal ribosomal entry site). together with ptbp1 is required for the translation initiation on the foot- and-mouth disease virus (fmdv) ires.
18799	probable transporter. the nucleotide-binding fold acts as an atp-binding subunit with atpase activity.
18800	
18801	
18802	
18803	
18804	
18805	
18806	
18807	
18808	selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
18809	the intermediate chains seem to help dynein bind to dynactin 150 kda component. may play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
18810	may be involved in transcriptional regulation.
18811	
18812	
18813	
18814	hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin a.
18815	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
18816	muscle contraction.
18817	
18818	
18819	
18820	may be involved in transcriptional regulation.
18821	
18822	
18823	
18824	
18825	
18826	
18827	plays an important role in the eukaryotic peptide chain initiation process.
18828	unknown. may be involved in sperm differentiation and proliferation.
18829	mitochondrial rhomboid serine protease processing the mitochondrial membrane fusion regulator mgm1, and the cytochrome c peroxidase (ccp1). required for tim11 stability, atp synthase complex assembly, mitochondrial morphology, cytochrome c (cyc1) storage and mitochondrial genome maintenance.
18830	may regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous f-actin. the localized formation of tara and trio complexes coordinates the amount of f-actin present in stress fibers. may also serve as a linker protein to recruit proteins required for f-actin formation and turnover.
18831	catalyzes the conversion of pgh2 to pgd2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. involved in a variety of cns functions, such as sedation, nrem sleep and pge2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. it is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
18832	
18833	
18834	component of the 60-80s u3 small nucleolar ribonucleoprotein (u3 snornp). required for the early cleavages during pre-18s ribosomal rna processing.
18835	
18836	
18837	
18838	
18839	
18840	
18841	
18842	
18843	
18844	
18845	
18846	
18847	
18848	
18849	beta-hexosaminidase a is responsible for the degradation of gm2 gangliosides, and a variety of other molecules containing terminal n-acetyl hexosamines, in the brain and other tissues. the form b is active against certain oligosaccharides. the form s has no measurable activity.
18850	plays an adhesive role by integrating collagen bundles. it is probably associated with the surface of interstitial collagen fibrils via col1. the col2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large n-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (by similarity).
18851	phosphorylates and activates not only pkb/akt, but also pka, pkc-zeta, p70s6k and p90s6k/rsk. may play a general role in signaling processes and in development (by similarity). isoform 3 is catalytically inactive.
18852	c1q associates with the proenzymes c1r and c1s to yield c1, the first component of the serum complement system. the collagen-like regions of c1q interact with the ca(2+)-dependent c1r(2)c1s(2) proenzyme complex, and efficient activation of c1 takes place on interaction of the globular heads of c1q with the fc regions of igg or igm antibody present in immune complexes.
18853	rna-binding protein that binds to several small cytoplasmic rna molecules known as y rnas. may stabilize these rnas from degradation.
18854	has antiproliferative properties in human melanoma cells and may contribute to terminal cell differentiation. may also function as a negative regulator of melanoma progression. formation in vivo in nude mice. they found that it selectively induces apoptosis in human breast cancer cells.
18855	inhibitor of the caspase-activated dnase (dff40).
18856	
18857	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
18858	3-phosphorylates the cellular phosphoinositide ptdins- 4,5-biphosphate (ptdins(4,5)p2) to produce ptdins-3, 4,5- triiphosphate (ptdins(3,4,5)p3). links g-protein coupled receptor activation to the secondary messenger ptdins(3,4,5)p3 production.
18859	
18860	
18861	required for pre-mrna splicing. can also modulate alternative splicing in vitro.
18862	
18863	possible cell adhesion receptor. it possesses an intrinsic protein tyrosine phosphatase activity (ptpase). it controls motor axon guidance.
18864	
18865	
18866	ppiases accelerate the folding of proteins during protein synthesis.
18867	
18868	
18869	pa2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
18870	
18871	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
18872	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
18873	unknown, though mvp is required for normal vault structure. vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport.
18874	
18875	promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. the c-terminus binds axonal microtubules while the n- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. the short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
18876	may have a role in spermatogenesis (by similarity).
18877	
18878	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
18879	inhibitor of the wnt signaling pathway. down-regulates beta-catenin. probably facilitate the phosphorylation of beta- catenin and apc by gsk3b (by similarity).
18880	glycosyltransferase involved in the elongation of o- linked ligands to activate notch signaling. possesses fucose- specific beta-1,3-n-acetylglucosaminyltransferase activity.
18881	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. may be important in urinary concentrating mechanisms.
18882	
18883	
18884	
18885	
18886	
18887	
18888	could play a role in neuronal development.
18889	implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2a, regulation of mrna trafficking and stability in association with elavl1, and inhibition of acetyltransferases as part of the inhat (inhibitor of histone acetyltransferases) complex (by similarity).
18890	straight-chain enoyl-coa thioesters from c4 up to at least c16 are processed, although with decreasing catalytic rate.
18891	
18892	
18893	interacts with dnak and grpe to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnak-independent fashion. unfolded proteins bind initially to dnaj; upon interaction with the dnaj-bound protein, dnak hydrolyzes its bound atp, resulting in the formation of a stable complex. grpe releases adp from dnak; atp binding to dnak triggers the release of the substrate protein, thus completing the reaction cycle. several rounds of atp-dependent interactions between dnaj, dnak and grpe are required for fully efficient folding.
18894	provides the precursors necessary for dna synthesis. catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
18895	
18896	
18897	may mediate the control of various cellular processes by insulin. when phosphorylated by the insulin receptor binds specifically to various cellular proteins containing sh2 domains such as phosphatidylinositol 3-kinase p85 subunit or grb2. activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (by similarity).
18898	
18899	receptor for extracellular adenine nucleotides such as atp and adp. in platelets binding to adp leads to mobilization of intracellular calcium ions via activation of phospholipase c, a change in platelet shape, and probably to platelet aggregation.
18900	
18901	
18902	forms part of the dystrophin-associated protein complex (dapc) which may link the cytoskeleton to the extracellular matrix. alpha-dystroglycan functions as a laminin receptor. binds to several types of arenaviruses. is a target for the entry of mycobacterium leprae into peripheral nerve schwann cells.
18903	converts monoacylglycerides to free fatty acids and glycerol. hydrolyzes 2-arachidonoylglycerol, a putative endocannabinoid (by similarity).
18904	binds differentially to the sh3 domains of certain proteins of signal transduction pathways. binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
18905	binds with high affinity to rna molecules that contain au-rich elements (ares) found within the 3-prime untranslated regions of many protooncogenes and cytokine mrnas. also binds to double- and single-stranded dna sequences in a specific manner and functions a transcription factor. each of the rna-binding domains specifically can bind solely to a single-stranded non-monotonous 5@#$%&-uuag-3@#$%& sequence and also weaker to the single-stranded 5@#$%&- ttaggg-3@#$%& telomeric dna repeat. binding of rrm1 to dna inhibits the formation of dna quadruplex structure which may play a role in telomere elongation. may be involved in translationally coupled mrna turnover. implicated with other rna-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding-region determinant of instability (mcrd) domain.
18906	
18907	
18908	required for protein transport from the er to the golgi complex.
18909	
18910	
18911	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
18912	
18913	
18914	
18915	
18916	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
18917	
18918	
18919	
18920	the 26s protease is involved in the atp-dependent degradation of ubiquitinated proteins. the regulatory (or atpase) complex confers atp dependency and substrate specificity to the 26s complex. interacts with the orphan nuclear hormone receptor mb67.
18921	
18922	
18923	
18924	
18925	
18926	may play a role in normal anterior-chamber and lens development.
18927	
18928	motor protein required for establishing a bipolar spindle. blocking of eg5 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.
18929	
18930	may have a role in germline development.
18931	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity (by similarity).
18932	
18933	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
18934	
18935	microtubule-dependent motor required for slow axonal transport of neurofilament proteins (nfh, nfm and nfl) (by similarity).
18936	
18937	acts on epoxides (alkene oxides, oxiranes) and arene oxides. plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. also determines steady-state levels of physiological mediators. has phosphatase activity (by similarity).
18938	
18939	
18940	
18941	
18942	catalyzes the covalent attachment of ubiquitin-like protein sumo-1 to other proteins.
18943	
18944	receptor for progesterone (by similarity). may be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) immunotoxicity.
18945	receptor for progesterone (by similarity). may be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) immunotoxicity.
18946	chemotactic for lymphocytes and monocytes. is a ligand for ccr1, ccr3 and ccr5. is an inhibitor of hiv-1-infection. the processed form ld78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is very potent inhibitor of hiv-1- infection. ld78-beta(3-70) is also a ligand for ccr1, ccr3 and ccr5.
18947	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
18948	
18949	
18950	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
18951	
18952	receptor for trypsin and trypsin-like enzymes coupled to g proteins that stimulate phosphoinositide hydrolysis.
18953	
18954	
18955	
18956	
18957	plasma membrane-associated small gtpase which cycles between an active gtp-bound and inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. seems to be involved in the regulation of the nadph oxidase.
18958	
18959	involved in postreplication repair of uv-damaged dna. postreplication repair functions in gap-filling of a daughter strand on replication of damaged dna (potential).
18960	acts as a rac1 guanine nucleotide exchange factor (gef).
18961	
18962	receptor for glutamate. l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists.
18963	
18964	
18965	
18966	
18967	
18968	
18969	
18970	required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and acts as leaky capper, slowing both polymerization and depolymerization. protects the growing actin fiber from tight capping proteins and so increases the time of elongation and the total amount of f-actin. may organize microtubules by mediating spindle positioning and movement in the budding process. potential target of the rho family members.
18971	the enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin k-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
18972	
18973	
18974	inhibits endothelial cell migartion (in vitro). may be involved in g protein-linked signaling (by similarity).
18975	
18976	
18977	
18978	
18979	
18980	
18981	
18982	
18983	
18984	
18985	
18986	
18987	
18988	
18989	
18990	may be involved in transcriptional regulation.
18991	
18992	
18993	
18994	
18995	
18996	essential for transcriptional activity of the hla class ii promoter; activation is via the proximal promoter. no dna binding of in vitro translated ciita was detected. may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal mhc class ii promoter, to elements of the transcription machinery, or both. alternatively it may activate hla class ii transcription by modifying proteins that bind to the mhc class ii promoter.
18997	
18998	
18999	muscle contraction.
19000	
19001	
19002	
19003	
19004	
19005	
19006	probable glucose transporter.
19007	
19008	
19009	
19010	may mediate a process in spermatogenesis or may play a role in sex ratio distortion.
19011	
19012	
19013	
19014	
19015	
19016	
19017	
19018	
19019	favors the reduction of estrogens and androgens. also has 20-alpha-hsd activity. uses preferentially nadh.
19020	
19021	
19022	
19023	receptor for interleukin-2.
19024	
19025	
19026	isoform 4 may play a role in spermatogenesis.
19027	
19028	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. socs2 appears to be a negative regulator in the growth hormone/igf1 signaling pathway.
19029	plus end-directed microtubule-dependent motor protein involved in mannnose-6-phosphate receptor (m6pr) transport to the plasma membrane (by similarity).
19030	
19031	
19032	
19033	
19034	plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations (by similarity).
19035	
19036	
19037	
19038	transcriptional repressor of a number of genes including sp1 target genes.
19039	
19040	circadian regulator that may act as a transcription factor. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition. the expression rhythms appear to originate from retina (by similarity).
19041	may be involved in transcriptional regulation. coactivator for steroid receptors.
19042	orphan nuclear receptor.
19043	
19044	required for the production of circadian rhythms. the biological cycle depends on the rhythmic formation and nuclear localization of the tim-per complex. light induces the degradation of tim, which promotes elimination of per. nuclear activity of the heterodimer coordinatively regulates per and tim transcription through a negative feedback loop. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition.
19045	probable helicase involved in mitochondrial functions. required for rapid turnover of mrnas containing a premature translational termination codon.
19046	mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient.
19047	required for protein transport from the er to the golgi complex.
19048	
19049	receptor for obesity factor (leptin). on ligand binding, mediates signaling through jak2/stat3. involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. may play a role in reproduction. can also mediate the erk/fos signaling pathway (by similarity).
19050	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. receptor for activin a, activin b and inhibin a.
19051	
19052	clathrin is the major protein of the polyhedral coat of coated pits and vesicles. two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-golgi network.
19053	
19054	
19055	binds specifically to peptidoglycan and is involved in innate immunity. function in intracellular killing of bacteria. the soluble form triggers apoptosis in vitro.
19056	
19057	likely to play an important role in intracellular protein and peptide metabolism.
19058	
19059	
19060	
19061	
19062	
19063	
19064	transports l-glutamate and also l- and d-aspartate. essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. acts as a symport by cotransporting sodium. negatively regulated by arl6ip5 (by similarity).
19065	appears to function in the signal transduction from ras activation to actin cytoskeletal remodelling. suppresses insulin- induced promoter activities through ap1 and sre. mediates rap1- induced adhesion.
19066	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
19067	
19068	
19069	
19070	
19071	function in general translation initiation by promoting the binding of the formylmethionine-trna to ribosomes. seems to function along with eif-2.
19072	
19073	regulates chordin (chrd). may play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis.
19074	
19075	
19076	this gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
19077	may be involved in transcriptional regulation.
19078	
19079	
19080	lif has the capacity to induce terminal differentiation in leukemic cells. its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
19081	
19082	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
19083	may play a role in signal transduction cascades in terminally differentiated cells.
19084	
19085	
19086	mono-heme cytochrome b. may act as a mediator of low potential couples in an electron flow through cardiac complex ii. is involved in system ii of the mitochondrial electron transport chain which is responsible for transferring electrons from succinate to ubiquinone (coenzyme q).
19087	
19088	
19089	involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. the multiple transmembrane domains and lumenal hydrophilic domains of the cholinephosphotransferase might participate in the transport process.
19090	
19091	
19092	
19093	
19094	
19095	
19096	provides the precursors necessary for dna synthesis. catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
19097	
19098	type i collagen is a member of group i collagen (fibrillar forming collagen).
19099	probably involved in a neuron-specific signal transduction.
19100	
19101	
19102	
19103	
19104	
19105	transcriptional repressor. binds with max to form a sequence-specific dna-binding protein complex which recognizes the core sequence cac[ga]tg. antagonizes myc transcriptional activity by competing for max (by similarity).
19106	
19107	
19108	
19109	
19110	likely involved in the mobilization of calcium as a result of the tcr/cd3 complex interaction. binds to cyclophilin b.
19111	
19112	
19113	
19114	
19115	
19116	
19117	
19118	may be involved in the regulation of specific developmental processes in the cns.
19119	plays a functional role in insulin and igf-i signaling. may serve to positively link the insulin and igf-i receptors to an uncharacterized mitogenic signaling pathway. interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. the interaction is mediated by the sh2 domain. also binds activated platelet-derived growth factor receptor and epidermal growth factor receptor.
19120	
19121	
19122	forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (by similarity).
19123	receptor-activated non-selective cation channel involved in detection of sensations such as cold, pain or sounds perception. involved in cold nociception by being activated by cold temperature below 17 degrees celsius, which is close to the noxious cold threshold. not involved in menthol sensation. also involved in pain sensation triggered by mustard oil or capsaicin, the pungent ingredient in chilli peppers, by being activated by these products. also acts as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (thc), the psychoactive component of marijuana. may be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. probably operated by a phosphatidylinositol second messenger system (by similarity).
19124	
19125	camp-dependent and sulfonylurea-sensitive anion transporter. key gatekeeper influencing intracellular cholesterol transport.
19126	binds to gc box promoters elements and selectively activates mrna synthesis from genes that contain functional recognition sites.
19127	
19128	
19129	putative odorant receptor.
19130	necessary for the atp-dependent first step of spliceosome assembly. binds to the intron branch point sequence (bps) 5@#$%&-uacuaac-3@#$%& of the pre-mrna. may act as transcription repressor.
19131	
19132	
19133	
19134	
19135	has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (cns) neurons. binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (by similarity).
19136	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. may be important in urinary concentrating mechanisms.
19137	
19138	transfers a sulfuryl group to an n-unsubstituted glucosamine linked to a 2-o-sulfo iduronic acid unit on heparan sulfate. catalyzes the o-sulfation of glucosamine in idoua2s-glcns and also in idoua2s-glcnh2. the substrate-specific o-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to herpes simplex virus-1 (hsv-1) and permits its entry. unlike 3-ost-1, does not convert nonanticoagulant heparan sulfate to anticoagulant heparan sulfate.
19139	may have a role in neuroendocrine differentiation.
19140	may act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking (by similarity).
19141	may be involved in spermatogenesis.
19142	
19143	
19144	
19145	
19146	may be involved in constitutive membrane trafficking including dynein-dependent intracellular vesicle transport. in vitro, binds calcium and phospholipids (by similarity).
19147	
19148	
19149	receptor for extracellular adenine nucleotides such as atp and adp. in platelets binding to adp leads to mobilization of intracellular calcium ions via activation of phospholipase c, a change in platelet shape, and probably to platelet aggregation.
19150	protein transport. probably involved in regulated exocytosis (by similarity).
19151	cytokine that binds to tnfrsf3/ltbr. binding to the decoy receptor tnfrsf6b modulates its effects. activates nfkb, stimulates the proliferation of t-cells, and inhibits growth of the adenocarcinoma ht-29. acts as a receptor for herpes simplex virus.
19152	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
19153	human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin s but that differ in their specificity due to amino acid sequence differences. cystatin sn, with a pi of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase i than is cystatin s, although both inhibit ficin equally well.
19154	transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. potential role in g2/m cell cycle regulation (by similarity).
19155	phosphorylates microtubule-associated protein 2 (map2). myelin basic protein (mbp), and elk-1; may promote entry in the cell cycle.
19156	
19157	
19158	
19159	
19160	seems to be required for maximal rate of protein biosynthesis. enhances ribosome dissociation into subunits and stabilizes the binding of the initiator met-trna(i) to 40 s ribosomal subunits.
19161	
19162	may function as a signaling adapter protein in lymphocytes (by similarity).
19163	chromosomal protein that binds to methylated dna. it can bind specifically to a single methyl-cpg pair. it is not influenced by sequences flanking the methyl-cpgs. mediates transcriptional repression through interaction with histone deacetylase and the corepressor sin3a.
19164	seems to be required for maximal rate of protein biosynthesis. enhances ribosome dissociation into subunits and stabilizes the binding of the initiator met-trna(i) to 40 s ribosomal subunits.
19165	aminopeptidase n is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
19166	
19167	
19168	
19169	serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors creb (camp response element-binding protein) and atf1 (activating transcription factor-1). essential role in the control of rela transcriptional activity in response to tnf. directly represses transcription via phosphorylation of ser-1 of histone h2a. mediates the mitogen- and stress-induced phosphorylation of histone h3 and high mobility group protein 14 (hmg-14).
19170	
19171	
19172	
19173	mediates transcriptional repression by certain nuclear receptors. part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.
19174	
19175	may function as a transcription factor.
19176	
19177	
19178	
19179	
19180	
19181	
19182	
19183	
19184	
19185	
19186	may be an ion-channel regulator. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis. involved in adhesive protein-protein and protein-carbohydrate interactions.
19187	
19188	
19189	
19190	
19191	could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. pro-apoptotic protein that functions intracellularly upstream of jnk activation and cytochrome c release.
19192	
19193	
19194	
19195	
19196	
19197	
19198	
19199	may be involved in transcriptional regulation.
19200	adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates.
19201	
19202	
19203	
19204	
19205	
19206	
19207	
19208	
19209	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
19210	
19211	
19212	
19213	
19214	
19215	
19216	
19217	
19218	
19219	atp-dependent rna helicase (potential).
19220	
19221	
19222	
19223	
19224	
19225	
19226	
19227	
19228	
19229	may participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. may control the properties of the membrane associated cytoskeleton.
19230	
19231	
19232	vinexin alpha isoform promotes up-regulation of actin stress fiber formation. vinexin beta isoform plays a role in cell spreading and enhances the activation of jnk/sapk in response to egf stimulation by using its third sh3 domain.
19233	
19234	dual specificity protein phosphatase. may be involved in the control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules (polyglucosans).
19235	
19236	may be involved in regulating membrane trafficking in the endosomal pathway. overexpression induces endosome aggregation. required to target tom1 to endosomes.
19237	
19238	adapter protein, which negatively regulates t-cell receptor (tcr) signaling. inhibits t-cell antigen-receptor induced activation of nuclear factor of activated t-cells. involved in the negative regulation of positive selection and mitosis of t-cells. may act by linking signaling proteins such as zap70 with cbl, leading to a cbl dependent degradation of signaling proteins.
19239	involved in the regulation of growth and apoptosis. mediates activation of stress-responsive mtk1/mekk4 mapkkk.
19240	the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-coa and co(2). it contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (e1), lipoamide acyltransferase (e2) and lipoamide dehydrogenase (e3).
19241	
19242	
19243	responsible for the synthesis of complex-type n-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
19244	
19245	
19246	
19247	
19248	component of the escrt-iii complex, which is required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs. the mvb pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. the escrt-iii complex is probably involved in the concentration of mvb cargo. required for sorting/trafficking of egf receptor. in case of infection, the hiv-1 virus takes advantage of the escrt-iii complex for budding and exocytic cargos of viral proteins.
19249	may participate in forming intercisternal cross-bridges of the golgi complex.
19250	required for protein transport from the er to the golgi complex.
19251	
19252	component of the inner kinetochore plate. required for normal kinetochore assembly.
19253	angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
19254	
19255	
19256	
19257	
19258	
19259	
19260	component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity.
19261	
19262	may be involved in the regulation of gene expression by covalent modification of histone proteins. the long isoform is a corepressor of estrogen receptor (er). the short isoform binds to er and sequesters it in the cytoplasm and enhances non-genomic responses of er.
19263	may be involved in the regulation of gene expression by covalent modification of histone proteins. the long isoform is a corepressor of estrogen receptor (er). the short isoform binds to er and sequesters it in the cytoplasm and enhances non-genomic responses of er.
19264	
19265	
19266	
19267	
19268	transcription factor involved in regulating gene activity following the primary growth factor response. binds to the dna sequence 5@#$%&-tga[cg]tca-3@#$%&.
19269	
19270	acts as a cofactor for xpo1/crm1-mediated nuclear export, perhaps as export complex scaffolding protein. bound to xpo1/crm1, stabilizes the xpo1/crm1-cargo interaction. in the absence of ran-bound gtp prevents binding of xpo1/crm1 to the nuclear pore complex. binds to chc1/rcc1 and increases the guanine nucleotide exchange activity of chc1/rcc1. recruits xpo1/crm1 to chc1/rcc1 in a ran-dependent manner.
19271	
19272	
19273	
19274	
19275	
19276	collagen type iii occurs in most soft connective tissues along with type i collagen.
19277	
19278	involved in cytokinesis (potential).
19279	
19280	
19281	
19282	
19283	
19284	
19285	
19286	responsible for the synthesis of complex-type n-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. can produce lactose.
19287	sodium-dependent glucose transporter (by similarity).
19288	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
19289	
19290	thiol protease. key protease responsible for the removal of the invariant chain from mhc class ii molecules. the bond- specificity of this proteinase is in part similar to the specificities of cathepsin l and cathepsin n.
19291	bifunctional subunit.
19292	
19293	
19294	dna-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (ig)/t-cell receptor gene segments. seems to recognize single-stranded dna ends generated by staggered breaks occuring at recombination hot spots.
19295	
19296	involved in mediating interferon-gamma-induced cell death.
19297	
19298	integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen c-propeptides, fibronectin and e-cadherin. it recognizes the proline-hydroxylated sequence g-f-p-g-e-r in collagen. it is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
19299	
19300	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
19301	may be involved in nucleolar-cytoplasmic transport. may play a fundamental role in early embryonic development, particularly in development of the craniofacial complex (by similarity).
19302	
19303	
19304	
19305	
19306	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
19307	
19308	inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the e1 alpha subunit, thus contributing to the regulation of glucose metabolism.
19309	
19310	
19311	
19312	the elongin bc complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different e3 ubiquitin ligase complexes, including the von hippel-lindau ubiquitination complex cbc(vhl). by binding to bc- box motifs it seems to link target recruitment subunits, like vhl and members of the socs box family, to cullin/rbx1 modules that activate e2 ubiquitination enzymes.
19313	
19314	
19315	
19316	
19317	
19318	spermine-binding protein is an androgen regulated ventral prostate glycoprotein that binds various polyamines.
19319	hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. does not have reverse activity.
19320	
19321	
19322	gtpase-activating protein (gap) for arf1 and arf5, which also shows strong gtpase activity. isoform 1 participates to the prevention of neuronal apoptosis by enhancing pi3 kinase activity. it aids the coupling of metabotropic glutamate receptor 1 (grm1) to cytoplasmic pi3 kinase by interacting with homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of ngf by activating nuclear pi3 kinase. isoform 2 does not stimulate pi3 kinase but may protect cells from apoptosis by stimulating akt. it also regulates the adapter protein 1 (ap-1)-dependent trafficking of proteins in the endosomal system.
19323	
19324	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (by similarity). probably encodes a dihydropyridine-insensitive current. vital for survival to adulthood.
19325	
19326	
19327	
19328	
19329	acts as the target for the cell-cycle arrest and immunosuppressive effects of the fkbp12-rapamycin complex.
19330	
19331	
19332	cytokine that binds to tnfrsf13b/taci and to tnfrsf17/bcma. may be implicated in the regulation of tumor cell growth. may be involved in monocyte/macrophage-mediated immunological processes.
19333	
19334	
19335	produces atp from adp in the presence of a proton gradient across the membrane. the alpha chain is a regulatory subunit.
19336	inhibits urokinase-type plasminogen activator. the monocyte derived pai-2 is distinct from the endothelial cell- derived pai-1.
19337	
19338	important for bud site selection.
19339	
19340	
19341	
19342	
19343	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
19344	may mediate a process in spermatogenesis or may play a role in sex ratio distortion.
19345	
19346	
19347	
19348	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. may be involved in the remodeling of the actin cytoskeleton. binds actin with high affinity both in the absence and presence of atp and its mechanochemical activity is inhibited by calcium ions. also acts as a gtpase activating protein on rho.
19349	probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. may mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. probably recognizes in a calcium-dependent manner high mannose n-linked oligosaccharides in a variety of pathogen antigens, including hiv-1 gp120, hiv-2 gp120, siv gp120, ebolavirus glycoproteins, hcv e2, and human sars coronavirus protein s. is a receptor for icam3, probably by binding to mannose-like carbohydrates. is presumably a coreceptor for the sars coronavirus.
19350	
19351	putative receptor involved in the development of neural and epithelial tissues.
19352	
19353	
19354	
19355	binds to activated cdc42 and rac1 but does not seem to stimulate their gtpase activity. associates with calmodulin.
19356	excises uracil residues from the dna which can arise as a result of misincorporation of dump residues by dna polymerase or due to deamination of cytosine.
19357	
19358	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters.
19359	
19360	v-snare that mediates vesicle transport pathways through interactions with t-snares on the target membrane. these interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.
19361	
19362	
19363	
19364	
19365	
19366	
19367	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
19368	
19369	
19370	
19371	
19372	
19373	
19374	
19375	
19376	plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates (by similarity).
19377	binds to all human somatostatin receptor (sstr) subtypes. it also inhibits camp production induced by forskolin through sstrs.
19378	
19379	
19380	
19381	
19382	
19383	
19384	transcriptional repressor.
19385	component of the transcription factor sl1/tifib complex involved in the assembly of the pic (preinitiation complex). recruits rna polymerase i to the rrna gene promoter via interaction with rrn3.
19386	
19387	
19388	
19389	
19390	
19391	
19392	
19393	
19394	
19395	neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. regulation of neurotransmitter release. the complex formed with nos1 and capon proteins is necessary for specific nitric-oxid functions at a presynaptic level.
19396	
19397	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
19398	
19399	
19400	
19401	
19402	
19403	
19404	
19405	may be involved in transcriptional regulation.
19406	
19407	
19408	
19409	
19410	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
19411	
19412	
19413	
19414	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
19415	
19416	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
19417	transports pantothenate, biotin and lipoate in the presence of sodium.
19418	
19419	
19420	
19421	binds the sequence 5@#$%&-atcaatcaa-3@#$%&. acts as a transcriptional activator of pf4 in complex with meis1. converted into a potent transcriptional activator by the (1;19) translocation. may have a role in steroidogenesis and, subsequently, sexual development and differentiation.
19422	
19423	
19424	
19425	may participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.
19426	
19427	may act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking (by similarity).
19428	
19429	maintains high levels of reduced glutathione in the cytosol.
19430	
19431	transcriptional regulator. isoform ii binds to the promoter region of s15 chorion gene, whereas isoform ii binds to cf2 promoter, thus having a probable autoregulatory role.
19432	
19433	catalyzes the exchange of adp and atp across the mitochondrial inner membrane.
19434	
19435	relieves dna strain that arise during duplication of mitochondrial dna.
19436	
19437	
19438	delays the onset of cell spreading in the early stages of cell adhesion to fibronectin. also involved in calcium- dependent exocytosis from pc12 cells.
19439	
19440	
19441	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis (by similarity).
19442	possesses intrinsic atp-dependent nucleosome remodelling activity. this activity may be required for transcriptional activation or repression of specific target promoters (by similarity). these may include the serpine1 and hiv-1 promoters and the sv40 enhancer, to which this protein can bind directly.
19443	
19444	
19445	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
19446	
19447	
19448	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (by similarity).
19449	
19450	
19451	may be involved in transcriptional regulation.
19452	
19453	
19454	
19455	may function in the secretion of milk-fat droplets. may act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (by similarity).
19456	
19457	
19458	blocks the elongation and depolymerization of the actin filaments at the pointed end. the tmod/tm complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (by similarity).
19459	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
19460	
19461	
19462	
19463	
19464	in vitro; can phosphorylate exogenous substrates on ser and thr residues. may be involved in the regulation of cellular growth and/or development.
19465	
19466	
19467	
19468	possible receptor for triiodothyronine.
19469	in a snrnp-free form (sf-a) may be involved in coupled pre-mrna splicing and polyadenylation process.
19470	in a snrnp-free form (sf-a) may be involved in coupled pre-mrna splicing and polyadenylation process.
19471	
19472	
19473	essential for cartilage morphogenesis and joint formation. inhibitor of bone morphogenetic proteins (bmp) signaling which is required for growth and patterning of the neural tube and somite (by similarity).
19474	
19475	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
19476	
19477	
19478	
19479	pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces.
19480	involved in neurodegeneration.
19481	
19482	
19483	
19484	blocks ras-mediated inhibition of integrin activation and modulates the erk map kinase cascade. inhibits rps6ka3 activities by retaining it in the cytoplasm (by similarity). inhibits both tnfrsf6- and tnfrsf1a-mediated casp8 activity and apoptosis. regulates glucose transport by controlling both the content of slc2a1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of slc2a4 from the cell interior to the surface.
19485	
19486	may play a role in macrophage activation and function.
19487	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
19488	
19489	
19490	the muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of g proteins. primary transducing effect is pi turnover.
19491	
19492	may function as a phosphatase involved in the regulation of cell growth and differentiation.
19493	may act as a scaffolding protein within caveolar membranes. interacts directly with g-protein alpha subunits and can functionally regulate their activity. may also regulate voltage-gated potassium channels.
19494	
19495	positive effector of the eif-2-alpha kinase activity of gcn2.
19496	required for preprotein translocation (by similarity).
19497	
19498	has chemotactic activity for neutrophils. may play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. in vitro, the processed form gro-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
19499	
19500	
19501	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling. phosphorylates ctnnb1 on ser-45.
19502	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
19503	the heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.
19504	
19505	
19506	protein tyrosine phosphatase which stimulates progression from g1 into s phase during mitosis. may play a role in the development and maintenance of differentiating epithelial tissues. enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
19507	
19508	
19509	
19510	orphan receptor.
19511	
19512	required for membrane traffic to the vacuole.
19513	cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. may play an important role in the development of the nervous system (by similarity).
19514	
19515	catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a thr-glu-tyr sequence located in map kinases. activates erk1 and erk2 map kinases.
19516	required for protein transport from the er to the golgi complex.
19517	orphan receptor.
19518	neuronal calcium sensor, regulator of g protein-coupled receptor phosphorylation in a calcium dependent manner. directly regulates grk1 (rhok), but not grk2 to grk5. can substitute for calmodulin (by similarity).
19519	involved in high-affinity copper uptake.
19520	
19521	component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. nua4 may also play a direct role in dna repair when directly recruited to sites of dna damage.
19522	
19523	
19524	
19525	
19526	component of e3 ubiquitin ligase complexes, including the cbc(vhl) (cul2-elonging bc-vhl) complex, which mediates the ubiquitination of hypoxia-inducible factor (hif). may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
19527	muscle contraction.
19528	
19529	may have a role in chylomicrons and vldl secretion and catabolism. required for efficient activation of lipoprotein lipase by apoc-ii; potent activator of lcat. apoa-iv is a major component of hdl and chylomicrons.
19530	cytokine receptor that binds to blc. blr1 exerts possibly a regulatory function in burkitt lymphoma (bl) lymphomagenesis and/or b-cell differentiation. it is a potential candidate for cell-cell interaction, and activation of mature b- lymphocytes in lymphatic tissues.
19531	component of pre-mrna cleavage complex ii and of the trna splicing endonuclease complex.
19532	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters.
19533	
19534	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
19535	involved in 40s ribosomal subunit biogenesis. it seems to play a role a methylation reaction in pre-rrna processing (by similarity).
19536	required for normal vision and courtship behavior in drosophila.
19537	high-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. may also function as an ecotropic retroviral leukemia receptor.
19538	
19539	
19540	
19541	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
19542	
19543	likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
19544	
19545	
19546	
19547	involved in the second step of gpi biosynthesis. de-n- acetylation of n-acetylglucosaminyl-phosphatidylinositol.
19548	
19549	may act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. may be involved in epidermal cell adhesion and epidermal structure and function.
19550	component of the adaptor complexes which link clathrin to receptors in coated vesicles. clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. ap2b1 is a subunit of the plasma membrane adaptor. the complex binds polyphosphoinositides.
19551	adhesion molecule that binds to leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2).
19552	
19553	
19554	
19555	mediates b-cell b-cell interactions. may be involved in the localization of b-cells in lymphoid tissues. binds sialylated glycoproteins; one of which is cd45. preferentially binds to alpha2,6-linked sialic acid. the sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of b-cell antigen receptor signaling. plays a role in positive regulation through interaction with src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their sh2 domains that block signal transduction through dephosphorylation of signaling molecules.
19556	
19557	
19558	
19559	
19560	
19561	
19562	
19563	unknown.
19564	
19565	in addition to its role as a glycolytic enzyme, it seems that pgk-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
19566	modulates the activity of rho-like proteins and connects extracellular signals to cytoskeletal activities. acts as a gdp- dissociation stimulator protein that stimulates the gdp-gtp exchange activity of rho-like gtpases and activates them. activates rac1, cdc42, and to a lesser extent rhoa (by similarity). affects invasiveness of t-lymphoma cells.
19567	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
19568	
19569	
19570	plays an adhesive role by integrating collagen bundles. it is probably associated with the surface of interstitial collagen fibrils via col1. the col2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large n-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (by similarity).
19571	
19572	
19573	cleaves ubiquitin fusion protein substrates. binds to the herpes virus protein vmw110 which may therefore modulate its substrate specificity or activity to stabilize viral proteins.
19574	
19575	
19576	component of adherens-type cell-cell and cell-matrix junctions. lacks phosphoglucomutase activity.
19577	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes.
19578	
19579	
19580	putative odorant receptor.
19581	
19582	has n-acetylated-alpha-linked-acidic dipeptidase (naaladase) activity. also exhibits a dipeptidyl-peptidase iv type activity. inactivate the peptide neurotransmitter n- acetylaspartylglutamate.
19583	processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. involved in melanosome transport. may also be required for some polarization process involved in dendrite formation.
19584	
19585	
19586	nmda receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine.
19587	
19588	
19589	
19590	
19591	
19592	involved in the transduction of mitogenic signals from the cell membrane to the nucleus. may play a role in the postsynaptic responses of hippocampal neuron.
19593	
19594	tumor-associated antigen.
19595	promotes the exchange of gdp by gtp. together with leukocyte antigen-related (lar) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.
19596	
19597	
19598	
19599	
19600	
19601	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
19602	
19603	
19604	mediator of diverse signals that repress rna polymerase iii transcription. inhibits the de novo assembly of tfiiib onto dna (by similarity).
19605	
19606	
19607	
19608	
19609	
19610	
19611	
19612	
19613	
19614	
19615	binds to the fc region of immunoglobulins gamma. high affinity receptor.
19616	
19617	
19618	
19619	
19620	
19621	
19622	
19623	
19624	
19625	could act as a modulator of transcription.
19626	
19627	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
19628	
19629	may be involved in transcriptional regulation.
19630	implicated in development of nervous system and pancreatic endocrine cells.
19631	
19632	
19633	required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors. may bind a rab gtpase such as vps21.
19634	
19635	might act as an e3 ubiquitin-protein ligase, or as part of the e3 complex, which accepts ubiquitin from specific e2 ubiquitin-conjugating enzymes, such as ube2l3/ubcm4, and then transfers it to substrates.
19636	promotes angiogenesis and the proliferation of endothelial cells. able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
19637	binds to gc box promoters elements and selectively activates mrna synthesis from genes that contain functional recognition sites.
19638	
19639	one of the multiple factors required for polyadenylation and 3@#$%&-end cleavage of mammalian pre-mrnas.
19640	
19641	
19642	
19643	
19644	
19645	overproduction suppresses the slow growth phenotype of cpr7 mutant cells.
19646	may play a role in developmental myelination of peripheral nerves.
19647	this is one of the five types (d1 to d5) of receptors for dopamine. the activity of this receptor is mediated by g proteins which inhibit adenylyl cyclase.
19648	tumor-associated antigen.
19649	visual signal transduction is mediated by a g-protein coupled cascade using cgmp as second messenger. this protein can be activated by cyclic gmp which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
19650	
19651	
19652	plays a role in transcriptional coactivation.
19653	
19654	
19655	troponin t is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin atpase activity.
19656	
19657	acts as a regulator of traf function by maintaining them in a latent state. overexpression inhibits traf2-mediated nf- kappa-b activation signaled by cd40, tnfr1 and tnfr2. blocks traf2 binding to lmp1 and inhibits lmp1-mediated nf-kappa-b activation.
19658	
19659	
19660	
19661	
19662	regulates intracellular concentrations of taurine and glutamate. negatively modulates slc1a1/eaac1 glutamate transport activity by decreasing its affinity for glutamate. may be involved in membrane traffic (by similarity).
19663	
19664	produced by activated monocytes and neutrophils and expressed at sites of inflammation. hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. gro-beta(5-73) shows a highly enhanced hematopoietic activity.
19665	collagen type iv is specific for basement membranes. vital for embryonic development.
19666	
19667	probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment.
19668	
19669	involved in translocation of long-chain fatty acids (lfca) across the plasma membrane. appears to be the principal fatty acid transporter in small intestinal enterocytes. plays a role in the formation of the epidermal barrier. required for fat absorption in early embryogenesis. has acyl-coa ligase activity for long-chain and very-long-chain fatty acids (by similarity).
19670	
19671	
19672	putative odorant receptor.
19673	
19674	
19675	
19676	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
19677	
19678	plays a role in the inducible expression of cytokine genes in t-cells, especially in the induction of the il-2 or il-4 gene transcription. also controls gene expression in embryonic cardiac cells. could regulate not only the activation and proliferation but also the differentiation and programmed death of t-lymphocytes as well as lymphoid and non-lymphoid cells.
19679	may be involved in transcriptional regulation.
19680	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
19681	binds differentially to the sh3 domains of certain proteins of signal transduction pathways. this protein binds preferentially to the abl1 proto-oncogene, src and grb2. shows gap activity for rac-related proteins but not for rho- or ras-related proteins. it inhibits pdgf-induced membrane ruffling mediated by rac (by similarity).
19682	
19683	
19684	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking among different compartments. modulates vesicle budding and uncoating within the golgi complex. deactivation induces the redistribution of the entire golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. in its gtp-bound form, its triggers the association with coat proteins with the golgi membrane. the hydrolysis of arf1-bound gtp, which is mediated by arfgaps proteins, is required for dissociation of coat proteins from golgi membranes and vesicles.
19685	
19686	
19687	
19688	
19689	
19690	
19691	required for protein transport from the er to the golgi complex.
19692	
19693	binds with high affinity to rna molecules that contain au-rich elements (ares) found within the 3@#$%& untranslated regions of many protooncogenes and cytokine mrnas. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain (by similarity).
19694	transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. retinyl esters are storage forms of vitamin a. lrat plays a critical role in vision. it provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.
19695	class-iii adh is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of s-(hydroxymethyl) glutathione.
19696	
19697	functions in nuclear protein import as nuclear transport receptor. serves as receptor for nuclear localization signals (nls) in cargo substrates. is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (npc) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus (by similarity). involved in nuclear import of m9- containing proteins. in vitro, binds directly to the m9 region of the heterogeneous nuclear ribonucleoproteins (hnrnp), a1 and a2 and mediates their nuclear import. appears also to be involved in hnrnp a1/a2 nuclear export. mediates the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones, and srp19.
19698	adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. can bind to fibrinogen, fibronectin, laminin and type v collagen.
19699	has a transcriptional repressor activity. induces apoptosis by activating jun n-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. may function in male germ cell development. has dna-binding activity and preferentially bound to double- stranded dna (by similarity).
19700	
19701	
19702	probable e3 ubiquitin-protein ligase required to ubiquitinate some nuclear proteins, and promote their subsequent degradation.
19703	unknown.
19704	
19705	
19706	this protein may be a lipid transport protein in schwann cells.
19707	not known, could be a tyrosine-phosphatase.
19708	may be involved in meiosis or the maturation of germ cells.
19709	
19710	may play a functional role in the immune system, as well as in the nervous system. induces b-cells to aggregate and improves their viability in vitro.
19711	
19712	synthesis and degradation of fructose 2,6-bisphosphate.
19713	
19714	
19715	
19716	neuronal cell surface protein that may be involved in cell recognition and cell adhesion. may mediate intracellular signaling.
19717	
19718	glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to g3p and the corresponding alcohols.
19719	
19720	
19721	
19722	
19723	
19724	
19725	visual pigments are the light-absorbing molecules that mediate vision. they consist of an apoprotein, opsin, covalently linked to cis-retinal.
19726	
19727	
19728	
19729	
19730	
19731	
19732	prohibitin inhibits dna synthesis. it has a role in regulating proliferation. as yet it is unclear if the protein or the mrna exhibits this effect. may play a role in regulating mitochondrial respiration activity and in aging.
19733	
19734	nuclear hormone receptor. high affinity receptor for triiodothyronine.
19735	exhibits outward rectification in a physiological k(+) gradient and mild inward rectification in symmetrical k(+) conditions.
19736	
19737	
19738	
19739	irreversible conversion of delta-1-pyrroline-5- carboxylate (p5c), derived either from proline or ornithine, to glutamate. this is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. the preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
19740	
19741	
19742	
19743	
19744	
19745	not known, associated with cell differentiation.
19746	
19747	
19748	
19749	involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. activates rac1 and rac2 small gtpases, probably by functioning as a guanine nucleotide exchange factor (gef), which exchanges bound gdp for free gtp. may also participate in il2 transcriptional activation via the activation of rac2.
19750	
19751	
19752	
19753	
19754	
19755	involved in serum exerting lectin activity. binds glcnac.
19756	
19757	
19758	
19759	
19760	
19761	
19762	
19763	
19764	
19765	cell surface proteoglycan that bears heparan sulfate.
19766	
19767	
19768	
19769	
19770	
19771	prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
19772	prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
19773	
19774	
19775	
19776	
19777	
19778	
19779	
19780	
19781	required for protein transport from the er to the golgi complex.
19782	
19783	sequence-selective dna-binding protein (by similarity).
19784	
19785	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
19786	
19787	
19788	
19789	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
19790	
19791	
19792	required for protein transport from the er to the golgi complex.
19793	
19794	functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. upon ligand activation through the released notch intracellular domain (nicd) it forms a transcriptional activator complex with rbp-j kappa and activates genes of the enhancer of split locus. affects the implementation of differentiation, proliferation and apoptotic programs. may regulate branching morphogenesis in the developing vascular system (by similarity).
19795	
19796	fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. fibrillin-1- containing microfibrils provide long-term force bearing structural support.
19797	putative receptor involved in the development of neural and epithelial tissues.
19798	
19799	
19800	
19801	e3 ubiquitin-protein ligase that accepts ubiquitin from the e2 ubiquitin-conjugating enzyme ube2d1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. it can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
19802	
19803	
19804	
19805	
19806	
19807	
19808	acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. one of the activated genes is an inhibitor of cyclin-dependent kinases. apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of bcl-2 expression.
19809	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
19810	type i collagen is a member of group i collagen (fibrillar forming collagen).
19811	
19812	mediates cellular binding of particles and immune complexes that have activated complement.
19813	
19814	
19815	involved in the release of sentrins (potential).
19816	specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3@#$%&end of 16s rrna in the 30s particle. its inactivation leads to kasugamycin resistance.
19817	specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3@#$%&end of 16s rrna in the 30s particle. its inactivation leads to kasugamycin resistance.
19818	
19819	may modulate the action of some growth factors on cell proliferation and differentiation. binds heparin (by similarity).
19820	essential component of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. when overexpressed in cells induces the formation of cytoplasmic annulate lamellae (al) (by similarity).
19821	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
19822	
19823	
19824	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
19825	
19826	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
19827	may be involved in transcriptional regulation.
19828	connects the two cox monomers into the physiological dimeric form (by similarity).
19829	catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. in intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (by similarity).
19830	
19831	
19832	
19833	
19834	this enzyme is required for electron transfer from nadp to cytochrome p450 in microsomes. it can also provide electron transfer to heme oxygenase and cytochrome b5. may function to clear the olfactory organ (antennae) from accumulating chemicals.
19835	
19836	
19837	
19838	
19839	
19840	
19841	
19842	
19843	
19844	
19845	may function as a transcriptional factor to modulate chondrogenesis in response to the camp pathway.
19846	terminates the action of gaba by its high affinity sodium-dependent reuptake into presynaptic terminals.
19847	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
19848	necessary for spliceosome assembly and for pre-mrna splicing.
19849	
19850	protein transport. probably involved in vesicular traffic (by similarity).
19851	major isoenzyme hydrolyzing the calcium-mobilizing second messenger ins(1,4,5)p3, this is a signal-terminating reaction.
19852	
19853	
19854	suppresses the insulin receptor and egfr-transduced mapk signaling pathway, but does not inhibit mapk activation by a constitutively active mutant ras. probably impairs the formation of gtp-ras.
19855	appears to mediate neuronal differentiation.
19856	
19857	
19858	
19859	
19860	
19861	
19862	required for vesicular transport from the er to the golgi complex. functions as a snare involved in the docking process of er-derived vesicles with the cis-golgi membrane (by similarity).
19863	
19864	hydrolyzes preferentially nucleoside 5@#$%&-diphosphates, nucleoside 5@#$%&-triphosphates are hydrolyzed only to a minor extent. the order of activity with different substrates is udp >> gdp = cdp = tdp, amp, adp, atp and ump are not substrates. preferred substrates for isoform 2 are ctp, udp, cdp, gtp and gdp, while isoform 1 utilizes utp and ttp.
19865	auxiliary enzyme of beta-oxidation. it participates in the metabolism of unsaturated fatty enoyl-coa esters having double bonds in both even- and odd-numbered positions. catalyzes the nadp-dependent reduction of 2,4-dienoyl-coa to yield trans-3- enoyl-coa.
19866	
19867	may serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
19868	
19869	
19870	
19871	plays a role in cytoplasmic trafficking of rna. binds to the cis-acting response element, a2re.
19872	creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
19873	in vitro, acts as a receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5).
19874	this antigen is associated with early stages of melanoma tumor progression. may play a role in growth regulation.
19875	may play a role in the er-associated degradation of misfolded glycoproteins.
19876	essential for the control of the cell cycle at the g1/s (start) transition.
19877	
19878	
19879	not known.
19880	
19881	probably involved in rna transcription.
19882	
19883	
19884	tfiia is a component of the transcription machinery of rna polymerase ii and plays an important role in transcriptional activation. interacts with tbp (the tata-binding protein).
19885	
19886	
19887	could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. may contribute to the metastatic phenotype.
19888	may be involved in transcriptional regulation.
19889	
19890	the crk-i and crk-ii forms differ in their biological activities. crk-ii has less transforming activity than crk-i. crk- ii mediates attachment-induced mapk8 activation, membrane ruffling and cell motility in a rac-dependent manner. involved in phagocytosis of apoptotic cells and cell motility via its interaction with dock1 and dock4.
19891	gp-ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the a1 domain of von willebrand factor, which is already bound to the subendothelium.
19892	inhibits ipf1/pdx1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (by similarity). in complex with cul3, involved in ubiquitination of both pcgf4 and h2afy.
19893	this protein mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient. this sodium channel may be present in both denervated and innervated skeletal muscle.
19894	
19895	
19896	
19897	
19898	facilitative glucose transporter (by similarity).
19899	provides cdp-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.
19900	
19901	
19902	unknown.
19903	
19904	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
19905	
19906	
19907	
19908	
19909	
19910	
19911	may be involved in acetic acid export.
19912	
19913	
19914	
19915	
19916	type i collagen is a member of group i collagen (fibrillar forming collagen).
19917	
19918	
19919	
19920	binds specifically to the dna sequence 5@#$%&-aacaat-3@#$%&. activates transcription of col2a1 and agc1 in vitro.
19921	
19922	
19923	
19924	
19925	
19926	
19927	
19928	
19929	hgf is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. it has no detectable protease activity.
19930	
19931	activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (apc/c). during telophase and in the subsequent g1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (d-box) and an additional degradation signal termed the ken box including ase1, cdc20, the b-type cyclins clb2 and clb3, the polo-like kinase cdc5 and hsl1, and recruits them in a c-box-dependent manner to the apc/c for ubiquitination and subsequent proteolysis. required for exit from mitosis, cytokinesis and formation of prereplicative complexes in g1. probably is the target of a bub2-dependent spindle checkpoint pathway.
19932	
19933	
19934	
19935	
19936	
19937	
19938	
19939	
19940	has growth-suppressing activity, induces arrest in g1 phase upon controlled expression.
19941	
19942	
19943	
19944	
19945	
19946	
19947	
19948	
19949	
19950	thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. in vitro it binds mhc, f-actin and native thin filaments, and modifies the activity of actin-activated myosin atpase. it may modulate muscle contraction or may play a more structural role.
19951	
19952	
19953	
19954	
19955	
19956	
19957	
19958	may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (by similarity).
19959	
19960	type i collagen is a member of group i collagen (fibrillar forming collagen).
19961	
19962	oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
19963	integrin alpha-v/beta-8 is a receptor for fibronectin.
19964	
19965	
19966	
19967	
19968	
19969	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
19970	calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic ca(2+) signaling.
19971	may be involved in bmp2-induced transcription (by similarity).
19972	
19973	
19974	
19975	acts as a sequence specific dna binding transcriptional activator or repressor. the isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. may be required in conjunction with tp73/p73 for initiation of tp53/p53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. involved in notch signaling by probably inducing jag1 and jag2. plays a role in the regulation of epithelial morphogenesis. the ratio of deltan-type and ta*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. required for limb formation from the apical ectodermal ridge.
19976	
19977	
19978	may regulate transcription of class ii genes through association with the rna polymerase ii-srb complex.
19979	
19980	
19981	cleaves the c-terminal propeptides of procollagen i, ii and iii. induces cartilage and bone formation.
19982	factor h functions as a cofactor in the inactivation of c3b by factor i and also increases the rate of dissociation of the c3bbb complex (c3 convertase) and the (c3b)nbb complex (c5 convertase) in the alternative complement pathway.
19983	
19984	
19985	may play an important role in the capacity of cells to respond to and cope with changes in their environment. may play a role in tissue remodeling and defense against pathogens.
19986	
19987	transport of phosphorylated lysosomal enzymes from the golgi complex and the cell surface to lysosomes. lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low ph mediates the dissociation of the complex. this receptor also binds igf2.
19988	receptor for members of the ephrin-a family. binds to ephrin-a1, -a4 and -a5. binds more poorly to ephrin-a2 and -a3. may play a role in a signal transduction process involved in hindbrain pattern formation.
19989	signal transducer and activator of transcription that mediates signaling by interferons (ifns). following type i ifn (ifn-alpha and ifn-beta) binding to cell surface receptors, jak kinases (tyk2 and jak1) are activated, leading to tyrosine phosphorylation of stat1 and stat2. the phosphorylated stats dimerize, associate with isgf3g/irf-9 to form a complex termed isgf3 transcription factor, that enters the nucleus. isgf3 binds to the ifn stimulated response element (isre) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. in response to type ii ifn (ifn-gamma), stat1 is tyrosine- and serine-phosphorylated. it then forms a homodimer termed ifn-gamma-activated factor (gaf), migrates into the nucleus and binds to the ifn gamma activated sequence (gas) to drive the expression of the target genes, inducing a cellular antiviral state.
19990	
19991	
19992	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. the n-terminus interacts with and regulates xpd whereas an intact c- terminus is required for a successful escape of rnap ii form the promoter.
19993	
19994	
19995	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
19996	
19997	
19998	
19999	
20000	
20001	this protein mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
20002	
20003	
20004	
20005	
20006	
20007	may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. when overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor (n-linked stearoyl- (c18) ceramide) in a fumonisin b1-independent manner (by similarity).
20008	after binding acetylcholine, the achr responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
20009	
20010	
20011	may hydrolyze fatty acids from s-acylated cysteine residues in proteins such as trimeric g alpha proteins or hras. has lysophospholipase activity (by similarity).
20012	may serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
20013	required for efficient splicing and pre-mrna nuclear retention.
20014	
20015	
20016	removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. prefers acyl chain lengths of 14 to 18 carbons.
20017	can repress hiv-1 transcription by binding to the hiv-1 long terminal repeat. involved in the regulation of cftr splicing. it promotes cftr exon 9 skipping by binding to the ug repeated motifs in the polymorphic region near the 3@#$%& splice site of this exon. the resulting aberrant splicing is associated with pathological features typical of cystic fibrosis.
20018	
20019	may play a role in the regulation of t and b-lymphocyte development and signal transduction.
20020	
20021	
20022	
20023	oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. targets to the golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.
20024	
20025	
20026	in peripheral tissues, the h1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
20027	
20028	interacts with lrp1/alpha-2-macroglobulin receptor and glycoprotein 330.
20029	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
20030	involved in neutrophil activation. in vitro, ena-78(8- 78) and ena-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.
20031	
20032	
20033	
20034	
20035	catalyzes the irreversible nadph-dependent deamination of gmp to imp. it functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of g to a nucleotides, and in maintaining the intracellular balance of a and g nucleotides.
20036	
20037	may be involved in several stages of intracellular trafficking.
20038	
20039	
20040	type i collagen is a member of group i collagen (fibrillar forming collagen).
20041	promotes the fragmentation of the mitochondrial network and its perinuclear clustering. can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. also mediates peroxisomal fission.
20042	
20043	
20044	
20045	
20046	
20047	
20048	collagen type iii occurs in most soft connective tissues along with type i collagen.
20049	
20050	involved in the specific phosphorylation of microtubule- associated proteins for tau, map2 and map4. phosphorylates cdc25c on ser-216.
20051	
20052	
20053	mediates homophilic cell-cell adhesion.
20054	
20055	
20056	
20057	apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated fas (cd95) or tnfr-1 receptors. the resulting aggregate called the death-inducing signaling complex (disc) performs caspase-8 proteolytic activation. active caspase-8 initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
20058	
20059	nuclease that induces dna fragmentation and chromatin condensation during apoptosis. degrades naked dna and induces apoptotic morphology.
20060	essential for the control of the cell cycle at the g1/s (start) transition.
20061	
20062	hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. may contribute to the native pacemaker currents in heart (if) and in neurons (ih). activated by camp. may mediate responses to sour stimuli.
20063	
20064	
20065	
20066	proton-conducting pore forming subunit of the membrane integral v0 complex of vacuolar atpase. v-atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
20067	fibrogenic lymphokine, that stimulates several biological activities related to scarring. stimulates synthesis of extracellular matrix protein like collagen, fibronectin and hyaluronan and fibroblast proliferation. induces chemotaxis of fibroblasts and smooth muscle cells. enhances wound healing and may be involved in accelerating epithelization by acting as direct mitogen and/or a motogen for epithelial cells (by similarity). may play a role in fibrogenesis associated with certain chronic inflammatory diseases.
20068	
20069	
20070	
20071	adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. preferentially binds to alpha2,3- linked sialic acid (by similarity).
20072	
20073	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
20074	
20075	
20076	
20077	
20078	possible transcription factor.
20079	
20080	binds il13 with a low affinity. together with il4r-alpha can form a functional receptor for il13. also serves as an alternate accessory protein to the common cytokine receptor gamma chain for il4 signaling, but cannot replace the function of gamma c in allowing enhanced il2 binding activity.
20081	
20082	may function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. may therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin.
20083	
20084	
20085	
20086	
20087	
20088	unknown.
20089	
20090	binds gtp, gdp and gmp. hydrolyzes gtp very efficiently; gdp rather than gmp is the major reaction product.
20091	
20092	
20093	
20094	
20095	
20096	nonessential protein required for the fusion of er- derived transport vesicles with the golgi complex. can be replaced by sft2.
20097	
20098	
20099	
20100	
20101	
20102	
20103	
20104	
20105	
20106	
20107	prevents motor-neuron apoptosis induced by a variety of signals.
20108	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
20109	gtpase-activating protein for rac1 and cdc42. promotes the exchange of rac or cdc42-bound gdp by gtp, thereby activating them. displays serine/threonine kinase activity.
20110	
20111	
20112	
20113	
20114	
20115	
20116	
20117	
20118	
20119	
20120	
20121	
20122	
20123	
20124	
20125	
20126	
20127	
20128	
20129	
20130	
20131	
20132	
20133	
20134	
20135	
20136	
20137	
20138	involved in dna double strand break (dsb) repair.
20139	possibly acts as a transcriptional regulatory factor.
20140	the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-coa and co(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (e1), dihydrolipoamide acetyltransferase (e2) and lipoamide dehydrogenase (e3).
20141	involved in several cell fate decisions that require cell-cell interactions. it is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10.
20142	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
20143	nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity (by similarity).
20144	transcription factor which binds specifically to the mef2 element present in the regulatory regions of many muscle- specific genes. activates transcription via this element. may be involved in muscle-specific and/or growth factor-related transcription.
20145	
20146	may be involved in transcriptional regulation.
20147	histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a role in histone code. does not demethylate histone h3 lys-4, h3 lys-27, h3 lys-36 nor h4 lys-20. only able to demethylate trimethylated h3 lys-9, with a weaker activity than jmjd2a, jmjd2c and jmjd2d. demethylation of lys residue generates formaldehyde and succinate.
20148	
20149	calcium-dependent, calmodulin-stimulated protein phosphatase. this subunit may have a role in the calmodulin activation of calcineurin. dephosphorylates hspb1 and ssh1.
20150	
20151	binds the ligand binding domain of the thyroid receptor (thrb) in the presence of triiodothyronine and enhances thrb- modulated transcription. golgi auto-antigen; probably involved in maintaining cis-golgi structure.
20152	calcium-regulated non-lysosomal thiol-protease (by similarity).
20153	
20154	fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
20155	
20156	
20157	
20158	
20159	
20160	
20161	muscle contraction.
20162	
20163	
20164	involved in complement regulation. can associate with lipoproteins and may play a role in lipid metabolism.
20165	trap proteins are part of a complex whose function is to bind calcium to the er membrane and thereby regulate the retention of er resident proteins.
20166	
20167	
20168	
20169	may play a role in the signal transduction pathway mediated by multiple wnt genes.
20170	cooperates with md-2 and tlr4 to mediate the innate immune response to bacterial lipopolysaccharide (lps). acts via myd88, tirap and traf6, leading to nf-kappa-b activation, cytokine secretion and the inflammatory response. up-regulates cell surface molecules, including adhesion molecules.
20171	prevents motor-neuron apoptosis induced by a variety of signals.
20172	
20173	
20174	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
20175	transforms 5-carboxymethyl-2-hydroxy-muconic semialdehyde (chms) into 5-carboxymethyl-2-hydroxy-muconic acid (chm).
20176	
20177	
20178	may play a role in developmental myelination of peripheral nerves.
20179	putative odorant receptor.
20180	
20181	xenin stimulates exocrine pancreatic secretion. it inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. in the gut, xenin interacts with the neurotensin receptor.
20182	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
20183	this is one of the five types (d1 to d5) of receptors for dopamine. the activity of this receptor is mediated by g proteins which inhibit adenylyl cyclase.
20184	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression.
20185	
20186	
20187	could regulate beta-glucan synthesis. overexpression provides resistance to hm-1 killer toxin.
20188	
20189	essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. gp30 is a potential ligand for this receptor. not activated by egf, tgf- alpha and amphiregulin.
20190	
20191	may be involved in transcriptional regulation.
20192	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
20193	inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. may be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles (by similarity).
20194	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. this subunit has a chymotrypsin-like activity.
20195	could function as a cell-adhesion protein. acts as a tumor suppressor. required for correct morphogenesis.
20196	required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
20197	binds to the fc region of immunoglobulins gamma. high affinity receptor.
20198	
20199	
20200	the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-coa and co(2). it contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (e1), lipoamide acyltransferase (e2) and lipoamide dehydrogenase (e3).
20201	
20202	
20203	
20204	
20205	this protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.
20206	
20207	involved in cell growth regulation. may be involved in the regulation of mitogenic signals and control of cell proliferation. involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (rtk) type, in particular egfr (by similarity).
20208	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
20209	
20210	may be involved in regulating membrane trafficking in the endosomal pathway. overexpression induces endosome aggregation. required to target tom1 to endosomes.
20211	
20212	transports l-glutamate and also l- and d-aspartate. essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. acts as a symport by cotransporting sodium.
20213	
20214	has a transcriptional repressor activity by cooperating with epc1. induces apoptosis by activating jun n-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. may function in male germ cell development. has dna-binding activity and preferentially bound to double-stranded dna (by similarity).
20215	component of the circadian clock or downstream effector of clock function. exhibits a high amplitude circadian rhythm with maximal levels in early evening. in constant darkness or constant light, the amplitude of the rhythm decreases (by similarity).
20216	may be involved in transcriptional regulation.
20217	accessory protein for the calcitonin gene-related peptide (cgrp) receptor. it modulates cgrp responsiveness in a variety of tissues.
20218	
20219	
20220	
20221	palmitoyltransferase specific for vac8. palmitoylates vac8 at one or more of its n-terminal cysteine residues, which is required for its proper membrane localization.
20222	
20223	
20224	
20225	
20226	enhances map3k1 oligomerization, which may relieve amino-terminal mediated map3k1 autoinhibition and lead to activation following autophosphorylation. may play a role in the regulation of vesicle targeting or fusion.
20227	chaperone. isoform 2 may function as an endogenous inhibitory regulator of hsc70 by competing the cochaperones.
20228	component of the signaling pathway of il-1 and toll-like receptors. inhibits cell activation by microbial products. recruits irak1 to the il-1 receptor complex. inhibits irak1 phosphorylation and kinase activity.
20229	probably plays a role in anchoring the complex to other cellular components.
20230	
20231	
20232	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
20233	orphan receptor.
20234	
20235	
20236	required for membrane traffic to the vacuole.
20237	
20238	part of the snapc complex required for the transcription of both rna polymerase ii and iii small-nuclear rna genes. binds to the proximal sequence element (pse), a non-tata-box basal promoter element common to these 2 types of genes. recruits tbp and brf2 to the u6 snrna tata box.
20239	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes.
20240	part of the ap-3 complex, an adapter-related complex which is not clathrin-associated. the complex is associated with the golgi region as well as more peripheral structures. it facilitates the budding of vesicles from the golgi membrane and may be directly involved in trafficking to lysosomes.
20241	component of the cleavage factor im (cfim) complex that plays a key role in pre-mrna 3@#$%& processing. involved in association with cpsf6 in pre-mrna 3@#$%&-end poly(a) site cleavage and poly(a) addition. nudt21/cpsf5 binds to cleavage and polyadenylation rna substrates.
20242	
20243	type i collagen is a member of group i collagen (fibrillar forming collagen).
20244	
20245	
20246	
20247	
20248	3-phosphorylates the cellular phosphoinositide ptdins- 4,5-biphosphate (ptdins(4,5)p2) to produce ptdins-3, 4,5- triiphosphate (ptdins(3,4,5)p3). links g-protein coupled receptor activation to the secondary messenger ptdins(3,4,5)p3 production.
20249	
20250	receptor on natural killer (nk) cells for hla-c alleles. does not inhibit the activity of nk cells.
20251	
20252	this is the smallest of the 5 chains of the enzymatic component (coupling factor cf(1)) of the mitochondrial atpase complex (by similarity).
20253	potential tumor suppressor. acts as a kras-specific effector protein. may promote apoptosis and cell cycle arrest.
20254	may participate in meiotic recombination.
20255	binds il13 with a low affinity. together with il4r-alpha can form a functional receptor for il13. also serves as an alternate accessory protein to the common cytokine receptor gamma chain for il4 signaling, but cannot replace the function of gamma c in allowing enhanced il2 binding activity.
20256	binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. may mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
20257	necessary for the synthesis of n-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in gpi-anchor biosynthesis.
20258	
20259	
20260	
20261	
20262	
20263	involved in several cell fate decisions that require cell-cell interactions. it is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10.
20264	
20265	may act as a gtpase activating protein for rab family protein(s).
20266	
20267	
20268	
20269	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
20270	
20271	
20272	
20273	may have a role in promoting cell migration (motogen).
20274	type i collagen is a member of group i collagen (fibrillar forming collagen).
20275	camp-dependent and sulfonylurea-sensitive anion transporter. key gatekeeper influencing intracellular cholesterol transport.
20276	receptor for all-trans- and 11-cis-retinal. binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.
20277	
20278	probable transcription regulator.
20279	
20280	
20281	
20282	
20283	
20284	
20285	
20286	
20287	
20288	
20289	
20290	
20291	gamma chains make up the fetal hemoglobin f, in combination with alpha chains.
20292	acts as a regulatory subunit of the 26 proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
20293	
20294	thought to form a receptor-activated non-selective calcium permeant cation channel. probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or g-protein coupled receptors. seems to be also activated by intracellular calcium store depletion.
20295	
20296	
20297	
20298	
20299	
20300	
20301	
20302	
20303	
20304	
20305	
20306	
20307	
20308	
20309	
20310	
20311	may play a role in the initial growth and guidance of axons. may be involved in cell adhesion.
20312	
20313	
20314	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
20315	type iv collagen is the major structural component of glomerular basement membranes (gbm), forming a @#$%&chicken-wire@#$%& meshwork together with laminins, proteoglycans and entactin/nidogen.
20316	
20317	
20318	transfers a sulfuryl group to an n-unsubstituted glucosamine linked to a 2-o-sulfo iduronic acid unit on heparan sulfate. unlike 3-ost-1, does not convert nonanticoagulant heparan sulfate to anticoagulant heparan sulfate (by similarity).
20319	
20320	
20321	
20322	
20323	
20324	
20325	
20326	
20327	
20328	probably involved in connections of major cytoskeletal structures to the plasma membrane.
20329	muscle contraction.
20330	
20331	muscle contraction.
20332	probable adapter protein involved in signaling pathways. interacts with the sh2 and sh3 domains of various signaling proteins when it is phosphorylated. may promotes fyn activation, possibly by disrupting intramolecular sh3-dependent interactions (by similarity).
20333	
20334	may act as a tumor suppressor.
20335	
20336	
20337	
20338	
20339	
20340	
20341	
20342	sulfate transporter. may play a role in endochondral bone formation.
20343	circadian regulator that may act as a transcription factor. behaves as a negative element in circadian transcriptional loop. does not appear to bind dna, suggesting indirect transcriptional inhibition. the expression rhythms appear to originate from retina (by similarity).
20344	
20345	
20346	
20347	may play a role in the signal transduction pathway mediated by multiple wnt genes.
20348	
20349	
20350	type xii collagen interacts with type i collagen- containing fibrils, the col1 domain could be associated with the surface of the fibrils, and the col2 and nc3 domains may be localized in the perifibrillar matrix (by similarity).
20351	involved in cytokinesis (potential).
20352	
20353	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
20354	ucp are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. as a result, energy is dissipated in the form of heat. may play a role in the modulation of tissue respiratory control. participates in thermogenesis and energy balance.
20355	mediates the na(+)-independent transport of organic anions such as sulfobromophthalein (bsp) and conjugated (taurocholate) and unconjugated (cholate) bile acids (by similarity).
20356	
20357	
20358	phosphorylates on ser and thr residues the goodpasture autoantigen (in vitro). isoform 2 seems to be less active.
20359	
20360	
20361	calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. phosphorylates camk1, camk1d, camk1g and camk4. involved in regulating cell apoptosis. promotes cell survival by phosphorylating akt1/pkb that inhibits pro-apoptotic bad/bcl2-antagonist of cell death.
20362	
20363	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
20364	
20365	may be involved in transcriptional regulation.
20366	induces a hyperpolarization-activated chloride current when expressed in xenopus oocytes. may be a modulator capable of activating endogenous oocyte channels.
20367	
20368	catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. has little activity towards prostaglandins a1 and e1.
20369	
20370	
20371	acts at e2f-responsive promoters to integrate signals provided by phd- and/or bromodomain-containing transcription factors (by similarity).
20372	
20373	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
20374	
20375	plays an important role in fat metabolism. it preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
20376	inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (by similarity).
20377	
20378	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
20379	potentiates but cannot initiate fas-induced apoptosis.
20380	
20381	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
20382	inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. may mediate the inhibitory effect of rac1 on endocytosis.
20383	protein tyrosine phosphatase which stimulates progression from g1 into s phase during mitosis. may play a role in the development and maintenance of differentiating epithelial tissues. enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
20384	binds rna in vitro. may be involved in rna metabolism. the expansion of the polyglutamine tract may alter this function.
20385	
20386	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
20387	
20388	granzyme b inhibitor.
20389	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
20390	specifically hydroxylates an asp or asn residue in certain epidermal growth factor-like (egf) domains of a number of proteins.
20391	
20392	necessary for the fragmentation of golgi stacks during mitosis and for their reassembly after mitosis. involved in the formation of the transitional endoplasmic reticulum (ter). the transfer of membranes from the endoplasmic reticulum to the golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (ter). vesicle budding from the ter is an atp-dependent process. the ternary complex containing ufd1l, vcp and nploc4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the er to the cytoplasm, where they are degraded by the proteasome. the nploc4-ufd1l-vcp complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (by similarity).
20393	
20394	
20395	potential tumor suppressor. acts as a kras-specific effector protein. may promote apoptosis and cell cycle arrest.
20396	thrombin, which cleaves bonds after arg and lys, converts fibrinogen to fibrin and activates factors v, vii, viii, xiii, and, in complex with thrombomodulin, protein c.
20397	may catalyze alpha-1,3 glycosidic linkages involved in the expression of lewis x/ssea-1 and vim-2 antigens.
20398	
20399	
20400	
20401	chaperone. isoform 2 may function as an endogenous inhibitory regulator of hsc70 by competing the cochaperones.
20402	
20403	
20404	
20405	
20406	plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. inhibits membrane fusion between transport vesicles and the plasma membrane. may modulate the assembly of trans-snare complexes between transport vesicles and the plasma membrane. inhibits translocation of glut4 from intracellular vesicles to the plasma membrane. competes with stxbp1 for stx1 binding (by similarity).
20407	
20408	accessory protein for mhc class-ii antigen/t-cell receptor interaction. may regulate t-cell activation. induces the aggregation of lipid rafts.
20409	
20410	
20411	
20412	
20413	
20414	
20415	phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin i. this isozyme may regulate glycogeneolysis in the testis.
20416	
20417	catalyzes the covalent attachment of ubiquitin to other proteins. may be involved in degradation of muscle-specific proteins.
20418	
20419	likely to play a regulatory role in the development of the ventral forebrain. may play a role in craniofacial patterning and morphogenesis.
20420	plays a role in apoptosis. suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. binding of cytochrome c to apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
20421	
20422	dual specificity kinase. is activated by cytokines and environmental stress in vivo. catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the map kinase p38.
20423	
20424	transcription factor that specifically binds to the octamer motif (5@#$%&-atttgcat-3@#$%&). regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. modulates transcription transactivation by nr3c1, ar and pgr.
20425	
20426	
20427	
20428	
20429	
20430	
20431	
20432	involved in cytokinesis (potential).
20433	cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. converts leukotriene c4 (ltc4) to leukotriene d4 (ltd4).
20434	this enzyme is required for electron transfer from nadp to cytochrome p450 in microsomes. it can also provide electron transfer to heme oxygenase and cytochrome b5.
20435	
20436	may play a role in meiosis as well as in neuron differentiation and/or function (by similarity).
20437	
20438	
20439	
20440	
20441	
20442	
20443	
20444	involved in vesicular protein trafficking.
20445	plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine.
20446	
20447	
20448	
20449	
20450	
20451	
20452	
20453	
20454	
20455	
20456	
20457	
20458	
20459	involved in the presentation of foreign antigens to the immune system.
20460	
20461	
20462	transcriptional repressor.
20463	
20464	arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
20465	
20466	
20467	
20468	
20469	
20470	
20471	
20472	
20473	
20474	
20475	
20476	
20477	may have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor.
20478	immediate-early protein likely to play a role in cell growth regulation (by similarity).
20479	
20480	
20481	
20482	
20483	
20484	
20485	
20486	
20487	
20488	
20489	transcriptional regulator that acts as repressor or activator. binds, in-vitro, to nf-e2 binding sites. play important roles in coordinating transcription activation and repression by mafk.
20490	
20491	
20492	may play a key role in signal transduction and growth control.
20493	
20494	
20495	
20496	
20497	
20498	plays a role in the formation of clathrin-coated invaginations and endocytosis.
20499	stimulates a migratory response in cd4+ lymphocytes, monocytes, and eosinophils. also induces t-lymphocyte expression of interleukin 2 receptor. ligand for cd4.
20500	
20501	
20502	stimulates the transcription of various genes by recognizing and binding to a ccaat motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
20503	
20504	
20505	
20506	
20507	
20508	may have an e3 ubiquitin ligase activity. may play a significant role in mediating the biological activity of the hiv-1 tat protein in vivo. binds specifically to the activation domain of hiv-1 tat and can also interact with the hiv-2 and eiav tat proteins in vivo.
20509	
20510	
20511	putative odorant receptor.
20512	
20513	
20514	
20515	
20516	
20517	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
20518	
20519	possible involvement in extravasation of leukocytes.
20520	may play a role in the regulation of hemostasis. the soluble form may have inhibitory properties towards coagulation factors. may interact with cellular g-protein signaling pathways. may bind to the dna 5@#$%&-gtcacatg-3@#$%&(cdei box).
20521	
20522	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
20523	
20524	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. displays high levels of activity on medium- and long chain acyl coas.
20525	ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. covalent attachment to its substrates requires prior activation by the e1 complex ube1c- appbp1 and linkage to the e2 enzyme ube2m. attachment of nedd8 to cullins activates their associated e3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
20526	may be an activator of the jnk/sapk pathway. phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
20527	
20528	
20529	
20530	activates the small gtpases arf1, arf5 and arf6. regulates the formation of post-golgi vesicles and modulates constitutive secretion. modulates phagocytosis mediated by fc gamma receptor and arf6. modulates pxn recruitment to focal contacts and cell migration.
20531	may be involved in transcriptional regulation.
20532	putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. preferentially binds to alpha2,6-linked sialic acid. the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. in the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their sh2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. induces apoptosis in acute myeloid leukemia (in vitro).
20533	the h3 subclass of histamine receptors could mediate the histamine signals in cns and peripheral nervous system. signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization.
20534	
20535	
20536	
20537	
20538	
20539	
20540	receptor for prostaglandin f2-alpha (pgf2-alpha). the activity of this receptor is mediated by g proteins which activate a phosphatidylinositol-calcium second messenger system. initiates luteolysis in the corpus luteum (by similarity).
20541	may stabilize hdl (high density lipoprotein) structure by its association with lipids, and affect the hdl metabolism.
20542	
20543	
20544	
20545	involved in muscle differentiation (myogenic factor). induces fibroblasts to differentiate into myoblasts. activates muscle-specific promoters. interacts with and is inhibited by the twist protein. this interaction probably involves the basic domains of both proteins (by similarity).
20546	
20547	probably important in the developing nervous system.
20548	promotes the exchange of cdc42-bound gdp by gtp. controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. cdc24 may be involved in the initial selection and organization of the budding site.
20549	
20550	
20551	
20552	
20553	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex.
20554	
20555	
20556	chemotactic for monocytes and t-lymphocytes. binds to cxcr3.
20557	may be involved in several stages of intracellular trafficking (by similarity).
20558	
20559	
20560	regulates intra- and extracellular levels of inorganic pyrophosphate (ppi), probably functioning as ppi transporter.
20561	
20562	
20563	
20564	
20565	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
20566	acts as an a-kinase anchoring protein by binding to the type ii regulatory subunit of protein kinase a and anchoring it to the mitochondrion. also involved in synchronization of mitochondrial fission.
20567	
20568	fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
20569	essential component of the scf (skp1-cul1-f-box protein) e3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. in the scf complex, serves as a rigid scaffold that organizes the skp1-f-box protein and rbx1 subunits. may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
20570	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
20571	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
20572	
20573	
20574	
20575	probably involved in the control of the cell cycle. interacts with cyclins a, b3, d, or e. activity of cdk2 is maximal during s phase and g2.
20576	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
20577	
20578	binds to the fc region of immunoglobulins epsilon. high affinity receptor. responsible for initiating the allergic response. binding of allergen to receptor-bound ige leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. the same receptor also induces the secretion of important lymphokines.
20579	
20580	
20581	
20582	exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities.
20583	
20584	amp deaminase plays a critical role in energy metabolism.
20585	
20586	the insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.
20587	
20588	
20589	may be involved in modulating chromatin formation and contribute to regulation of cell proliferation.
20590	
20591	isoform c is proteolytically inactive.
20592	presents carbohydrate ligands to selectins. also implicated in tumor cell metastasis.
20593	
20594	angiogenesis inhibitor. inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. this inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. acts in an autocrine manner.
20595	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
20596	
20597	may play an important role in fibrillogenesis by controlling lateral growth of collagen ii fibrils.
20598	
20599	
20600	
20601	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
20602	suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. regulates cell death by controlling the mitochondrial membrane permeability. appears to function in a feedback loop system with caspases. inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1).
20603	
20604	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters. it binds to a tax-responsive enhancer element in the long terminal repeat of htlv-i.
20605	involved in the transcriptional regulation of genes required for mesoderm differentiation. probably plays a role in limb pattern formation.
20606	
20607	promotes cell adhesion (by similarity).
20608	
20609	has deoxyribonuclease activity. it is endonucleolytic with single-strand and exonucleolytic with double-strand dna. may play an important role in cell development as well as dna repair and recombination.
20610	
20611	catalyzes the transfer of ptdins and phosphatidylcholine between membranes.
20612	
20613	
20614	suppresses neurite outgrowth (by similarity).
20615	
20616	involved in the transport of proteins between the endosomes and the trans golgi network.
20617	
20618	integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis.
20619	
20620	
20621	
20622	required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors. may bind a rab gtpase such as vps21.
20623	
20624	
20625	
20626	seems to be a intermediate filament associated protein that links endocytic vesicles to microtubules.
20627	
20628	
20629	sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. controls the reabsorption of sodium in kidney, colon, lung and sweat glands. also plays a role in taste perception.
20630	
20631	
20632	
20633	
20634	
20635	a spliceosome-associated protein; may play a role in cross-intron bridging of u1 and u2 snrnps in the mammalian a complex.
20636	
20637	
20638	involved in calcium binding and microtubule stabilization.
20639	
20640	
20641	
20642	
20643	
20644	
20645	
20646	
20647	
20648	
20649	
20650	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
20651	
20652	
20653	
20654	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
20655	
20656	
20657	
20658	
20659	
20660	
20661	
20662	
20663	appears to mediate interactions between cells and the extracellular matrix. substrate-adhesion molecule that appears to inhibit cell migration. may play a role in supporting the growth of epithelial tumors.
20664	
20665	
20666	
20667	
20668	
20669	
20670	
20671	
20672	
20673	
20674	
20675	
20676	
20677	
20678	
20679	
20680	
20681	
20682	
20683	this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of sodium and potassium ions across the plasma membrane. this action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
20684	not yet known, orphan transporter.
20685	
20686	
20687	
20688	
20689	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules.
20690	
20691	
20692	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
20693	
20694	
20695	
20696	essential for the development of polarized epithelia and for cell polarity associated with asymmetric cell division of neuroblasts during development. isoform p78 has an essential role in control of cell proliferation and differentiation during development and could act as tumor suppressor. isoform p217 has an accessory function in this respect.
20697	
20698	
20699	
20700	
20701	
20702	
20703	
20704	tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. phosphorylates stat6, irs1, irs2 and pi3k.
20705	
20706	strong transcriptional activator; dna-binding protein that specifically recognize the sequence 5@#$%&-yaac[gt]g-3@#$%&. could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and b-lymphoid cells.
20707	
20708	type iv collagen is the major structural component of glomerular basement membranes (gbm), forming a @#$%&chicken-wire@#$%& meshwork together with laminins, proteoglycans and entactin/nidogen.
20709	
20710	
20711	
20712	
20713	extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. regulates microtubule function in neurons and neuronal migration. affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. enzymatic activity is important for the modulation of cell adhesion. binding to the extracellular domains of lipoprotein receptors vldlr and apoer2 induces tyrosine phosphorylation of dab1 and modulation of tau phosphorylation (by similarity).
20714	
20715	plays a role in the toxic effects of organotins.
20716	
20717	saposin d is a specific sphingomyelin phosphodiesterase activator (ec 3.1.4.12).
20718	
20719	implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.
20720	
20721	
20722	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (by similarity). probably encodes a dihydropyridine-insensitive current. vital for survival to adulthood.
20723	electrically silent transporter system. mediates sodium and chloride reabsorption.
20724	
20725	have a function in liver regeneration and spermatogenesis (by similarity).
20726	
20727	
20728	transports nucleotide sugars from the cytosol into golgi vesicles where glycosyltransferases function.
20729	
20730	
20731	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
20732	f-actin capping proteins bind in a ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
20733	required for normal golgi morphology and function.
20734	involved in muscle differentiation (myogenic factor). induces fibroblasts to differentiate into myoblasts. probable sequence specific dna-binding protein.
20735	the association of the dr1/drap1 heterodimer with tbp results in a functional repression of both activated and basal transcription of class ii genes. this interaction precludes the formation of a transcription-competent complex by inhibiting the association of tfiia and/or tfiib with tbp. can bind to dna on its own.
20736	
20737	
20738	gfap, a class-iii intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
20739	
20740	catalyzes the conjugation of leukotriene a4 with reduced glutathione to form leukotriene c4.
20741	
20742	structural component of hyaline cartilage and vitreous of the eye.
20743	
20744	involved in the presentation of foreign antigens to the immune system.
20745	shows weak transcriptional activatory activity. transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide.
20746	
20747	
20748	
20749	
20750	
20751	
20752	
20753	
20754	
20755	works in concert with the 5alpha/5beta-steroid reductases to convert steroid hormones into the 3alpha/5alpha and 3alpha/5beta-tetrahydrosteroids. catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5alpha-dht) to 5-alpha-androstane-3alpha,17beta-diol (3-alpha-diol).
20756	
20757	
20758	
20759	this is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of na(+) and k(+) ions across the plasma membrane. the exact function of the beta-2 subunit is not known.
20760	collagen type iv is specific for basement membranes. vital for embryonic development.
20761	
20762	
20763	involved in microtubule organization by the microtubule organizing center, the spindle pole body (spb). probably part of the microtubule attachment site at the spb.
20764	ubiquitin-like modifier protein which binds to a number of as yet unidentified target proteins.
20765	
20766	
20767	may enhance gap-43 expression by binding to the ngf- regulatory region of its mrna (by similarity).
20768	
20769	
20770	cerebellin exerts neuromodulatory functions. directly stimulates norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.
20771	
20772	induces cardiac myocyte hypertrophy in vitro. binds to and activates the ilst/gp130 receptor.
20773	may be required for cell division and may have a role during g1 or s phase.
20774	involved in the targeting and/or fusion of transport vesicles to their target membrane.
20775	may play a role in antiviral host defense. protects against infection by a neurovirulent strain of sindbis virus. may play a role in autophagy.
20776	component of the smcc mediator complex, a complex that can either repress or activate transcription. mediator complexes are essential for basal and regulated expression of nearly all rna polymerase ii-dependent genes. they may act as a bridge, conveying regulatory information from enhancers and other control elements to the promoter. the smcc mediator complex can also act independently of the rna polymerase ii ctd.
20777	
20778	
20779	activates the jnk pathway. plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. phosphorylates and inactivates the protein phosphatase ssh1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. decreased cofilin activity may lead to stabilization of actin filaments.
20780	
20781	may play a role in the regulation of ionic transport. binds calcium.
20782	binds to cytidine clusters in double-stranded dna.
20783	the gamma-ctf peptides as well as the caspase-cleaved peptides, including c31, are potent enhancers of neuronal apoptosis.
20784	
20785	
20786	
20787	unknown.
20788	
20789	factor viii, along with calcium and phospholipid, acts as a cofactor for factor ixa when it converts factor x to the activated form, factor xa.
20790	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
20791	
20792	
20793	
20794	
20795	
20796	
20797	has an effect on position-effect variegation.
20798	may play a role in prolonged long term-potentiation (ltp) maintenance (by similarity).
20799	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex.
20800	
20801	
20802	
20803	
20804	
20805	
20806	
20807	
20808	
20809	
20810	
20811	
20812	
20813	
20814	band 3 is the major integral glycoprotein of the erythrocyte membrane. band 3 has two functional domains. its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin.
20815	may function as an antagonist of fibroblast growth factor (fgf) pathways and may negatively modulate respiratory organogenesis.
20816	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&. activates transcription of pf4 in complex with meis1.
20817	
20818	
20819	
20820	
20821	
20822	
20823	
20824	
20825	
20826	
20827	
20828	transcription factor which binds specifically to the mef2 element present in the regulatory regions of many muscle- specific genes. activates transcription via this element. may be involved in muscle-specific and/or growth factor-related transcription.
20829	
20830	
20831	
20832	
20833	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. combines rna-binding and ppiase activities (by similarity).
20834	
20835	
20836	
20837	
20838	
20839	
20840	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
20841	
20842	
20843	
20844	
20845	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling. phosphorylates ctnnb1 on ser-45.
20846	catalyzes the phosphorylation of phosphatidylinositol-4- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol-4,5-biphosphate.
20847	part of the complex catalyzing the transfer of n- acetylglucosamine from udp-n-acetylglucosamine to phosphatidylinositol, the first step of gpi biosynthesis.
20848	mediates the voltage-dependent potassium ion permeability of excitable membranes. channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
20849	eliminates the production of nonsense-containing rnas (by similarity).
20850	
20851	3@#$%&-to-5@#$%& exoribonuclease specific for small oligoribonucleotides. active on small (primarily </=5 nucleotides in length) single-stranded rna and dna oligomers. may have a role for cellular nucleotide recycling.
20852	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems. the g(o) protein function is not clear.
20853	
20854	hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
20855	
20856	
20857	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
20858	
20859	
20860	receptor for the lysosphingolipid sphingosine 1- phosphate (s1p). s1p is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. when expressed in rat htc4 hepatoma cells, is capable of mediating s1p-induced cell proliferation and suppression of apoptosis.
20861	
20862	calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. it may act in assisting protein assembly and/or in the retention within the er of unassembled protein subunits. it seems to play a major role in the quality control apparatus of the er by the retention of incorrectly folded proteins.
20863	
20864	
20865	may be associated with the transformation of neuroendocrine cells.
20866	
20867	
20868	
20869	
20870	component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity.
20871	
20872	
20873	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
20874	may be involved in transcriptional regulation.
20875	bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. catalyzes the formation of 3- ketoacyl-coa intermediates from both straight-chain and 2-methyl- branched-chain fatty acids (by similarity).
20876	
20877	
20878	
20879	
20880	
20881	
20882	may be involved in transcriptional regulation.
20883	
20884	
20885	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein (by similarity).
20886	
20887	transcription activator that binds dna cooperatively with dp proteins through the e2 recognition site, 5@#$%&-tttc[cg]cgc- 3@#$%& found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the drtf1/e2f complex functions in the control of cell-cycle progression from g1 to s phase. e2f-4 binds with high affinity to p107 and p130. in some instances, can also bind rb protein.
20888	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling.
20889	
20890	integrin alpha-v/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von willebrand factor. integrin alpha-iib/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. integrins alpha-iib/beta-3 and alpha-v/beta-3 recognize the sequence r-g-d in a wide array of ligands. integrin alpha-iib/beta-3 recognizes the sequence h-h-l-g-g-g-a-k-q-a-g-d-v in fibrinogen gamma chain. following activation integrin alpha- iib/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. this step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
20891	
20892	
20893	may be involved in several stages of intracellular trafficking (by similarity).
20894	may be involved in transcriptional regulation.
20895	required for synthesis of pyridoxal-5-phosphate from vitamin b6.
20896	
20897	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. displays glutathione peroxidase activity with cumene hydroperoxide.
20898	shows chemotactic activity for monocytes, resting t- lymphocytes, and neutrophils, but not for activated lymphocytes. inhibits proliferation of myeloid progenitor cells in colony formation assays. this protein can bind heparin. binds ccr1. ccl23(19-99), ccl23(22-99), ccl23(27-99), ccl23(30-99) are more potent chemoattractants than the small inducible cytokine a23.
20899	receptor for atp that acts as a ligand gated ion channel. responsible for atp-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. could function in both fast synaptic transmission and the atp-mediated lysis of antigen-presenting cells.
20900	
20901	ubiquitin-like protein which binds to a wide range of target proteins. does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. plays a role in a number of cellular processes such as nuclear transport, dna replication and repair, mitosis and signal transduction. involved in targeting rangap1 to the nuclear pore complex protein ranbp2.
20902	
20903	
20904	may play a role in cell-cell recognition and signaling.
20905	protein kinase that is involved in mitotic regulation. may have a role at the g2-m transition. may also play a role in meiosis. isoform 1 but not isoform 2 appears to play a role in centrosome splitting. isoform 1 phosphorylates and activates nek11 in g1/s-arrested cells. isoform 2, which is not present in the nucleolus, does not.
20906	involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. mediates its effects by interactions with a number of other regulators of apoptosis. isoform 1 inhibits apoptosis while isoform 2 promotes it.
20907	required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier. functions as a homophilic cell-adhesion molecule. may play a role in early neuronal differentiation and axon outgrowth.
20908	
20909	catalyzes the production of gaba.
20910	
20911	acts as a transcriptional regulator of pax6. acts as a transcriptional activator of pf4 in complex with pbx1 or pbx2. required for hematopoiesis, megakaryocyte lineage development and vascular patterning. may function as a cofactor for hoxa7 and hoxa9 in the induction of myeloid leukemias.
20912	calcium/calmodulin-dependent enzyme responsible for smooth muscle contraction via phosphorylation of a specific serine in the n-terminus of myosin light chains (mlc), an event that facilitates myosin interaction with actin filaments. central determinant in the development of vascular permeability and tissue edema formation. in the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. critical participant in signaling sequences that result in fibroblast apoptosis.
20913	may play a role in the regulation of pre-mrna splicing.
20914	may act as a scaffolding protein within caveolar membranes. interacts directly with g-protein alpha subunits and can functionally regulate their activity. may also regulate voltage-gated potassium channels.
20915	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems. transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cgmp-phosphodiesterase.
20916	
20917	receptor for neuropeptide y and peptide yy. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity. seems to be associated with food intake. could be involved in feeding disorders.
20918	
20919	
20920	
20921	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. binds poly(rg).
20922	
20923	general coactivator that functions cooperatively with tafs and mediates functional interactions between upstream activators and the general transcriptional machinery. binds single-stranded dna.
20924	
20925	
20926	involved in peroxisome biosynthesis and integrity. assembles membrane vesicles before the matrix proteins are translocated. as a docking factor for pex19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
20927	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex.
20928	
20929	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
20930	
20931	
20932	
20933	
20934	
20935	
20936	may participate in diverse steps of neurogenesis. binds calcium.
20937	may be involved in the regulation of spermatogenesis and sperm maturation (by similarity).
20938	
20939	
20940	ensures, in conjunction with srp, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.
20941	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. this receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. it is a cation-specific, but otherwise relatively nonselective, ion channel.
20942	upstream regulator of interferon-induced serine/threonine protein kinase r (pkr). may block the pkr- inhibitory function of p58ipk, resulting in restoration of kinase activity and suppression of cell growth.
20943	
20944	may be involved in fusion of er-derived transport vesicles with the golgi complex.
20945	
20946	
20947	
20948	
20949	
20950	inhibits activated protein c as well as plasminogen activators.
20951	
20952	
20953	acetyltransferase enzyme. acetylates histones, giving a specific tag for transcriptional activation. also acetylates non- histone proteins, like ncoa3 coactivator. mediates camp-gene regulation by binding specifically to phosphorylated creb protein. cbp, as coactivator, augments the activity of phosphorylated creb to activate transcription of camp-responsive genes.
20954	
20955	
20956	
20957	
20958	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
20959	may play a role in germ line formation.
20960	
20961	senses unfolded proteins in the lumen of the endoplasmic reticulum via its n-terminal domain which leads to enzyme auto- activation. the active endoribonuclease domain splices xbp1 mrna to generate a new c-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
20962	
20963	
20964	involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. may be involved in the release of components of the bilayered coat from the endosomal membrane. the association with escrt-iii complex mediates the atp- dependent disassembly of the escrt-iii complex. in case of infection, the hiv-1 virus takes advantage of it for budding and exocytic cargos of viral proteins.
20965	
20966	
20967	
20968	
20969	
20970	
20971	
20972	
20973	adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. may link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. plays an important role in synapse formation and in the organization of utrn and acetylcholine receptors at the neuromuscular synapse. binds to phosphatidylinositol 4,5-biphosphate (by similarity).
20974	receptor for il10 and il22. serves as an accessory chain essential for the active il10 receptor complex and to initiate il10-induced signal transduction events.
20975	
20976	stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.
20977	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
20978	this protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate (by similarity).
20979	
20980	
20981	
20982	stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
20983	
20984	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
20985	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
20986	
20987	
20988	
20989	
20990	
20991	tumor-associated antigen.
20992	
20993	
20994	
20995	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (by similarity).
20996	
20997	
20998	
20999	
21000	
21001	
21002	
21003	
21004	
21005	
21006	
21007	
21008	probable e3 ubiquitin ligase protein, which mediates ubiquitination and subsequent proteasomal degradation of target proteins. may function as a facilitator or regulator of transcriptional activation by myc. may have a role during synaptogenesis.
21009	
21010	
21011	
21012	
21013	binds the poly(a) tail of mrna. may be involved in cytoplasmic regulatory processes of mrna metabolism. its function in translational initiation regulation can either be enhanced by paip1 or repressed by paip2. can probably bind to cytoplasmic rna sequences other than poly(a) in vivo. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain (by similarity).
21014	
21015	
21016	
21017	
21018	it is involved in repression by a1-alpha2 and alpha2 and in other systems as a general repressor of transcription. this protein has no obvious dna-binding domains. it might not interact directly with dna but with dna-bound proteins.
21019	
21020	
21021	
21022	
21023	
21024	
21025	
21026	
21027	catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a thr-glu-tyr sequence located in map kinases. activates the erk1 and erk2 map kinases.
21028	
21029	
21030	
21031	
21032	
21033	
21034	required for protein transport from the er to the golgi complex.
21035	
21036	
21037	
21038	
21039	
21040	
21041	
21042	
21043	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
21044	
21045	
21046	
21047	
21048	
21049	probable pseudophosphatase. lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. the pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts.
21050	
21051	ligand for cd2. might facilitate interaction between activated lymphocytes. probably involved in regulating t-cell activation.
21052	
21053	
21054	
21055	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. receptor for tgf-beta. may bind activin as well.
21056	
21057	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
21058	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
21059	
21060	this is a receptor for retinoic acid. this metabolite has profound effects on vertebrate development. retinoic acid is a morphogen and is a powerful teratogen. this receptor controls cell function by directly regulating gene expression.
21061	involved in transcription.
21062	
21063	collagen type iii occurs in most soft connective tissues along with type i collagen.
21064	
21065	
21066	
21067	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form.
21068	
21069	
21070	required for protein transport from the er to the golgi complex.
21071	
21072	component of a protein kinase signal transduction cascade. activates the csbp2, p38 and jnk mapk pathways, but not the erk pathway. specifically phosphorylates and activates map2k4 and map2k6.
21073	
21074	functions as a sorting receptor in the golgi compartment and as a clearance receptor on the cell surface. required for protein transport from the golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (m6pr). also required for protein transport from the golgi apparatus to the endosomes. promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of bdnf (probdnf) and ngfb (prongfb). also acts as a receptor for neurotensin. may promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular lpl. probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter slc2a4/glut4 (glut4 storage vesicles, or gsvs). these vesicles provide a stable pool of slc2a4 and confer increased responsiveness to insulin. may also mediate transport from the endoplasmic reticulum to the golgi.
21075	
21076	
21077	component of pa700, an atp-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20s proteasome) of the 26s complex. specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone t3-independent manner) and with retinoid x receptor (rxr). could be e3 ubiquitin- protein ligase which accepts ubiquitin from an e2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
21078	type i collagen is a member of group i collagen (fibrillar forming collagen).
21079	signal-transducing molecule. may have a common pathway with il6st. the soluble form inhibits the biological activity of lif by blocking its binding to receptors on target cells.
21080	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
21081	
21082	
21083	
21084	
21085	
21086	
21087	
21088	specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.
21089	plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. could be an adhesion molecule active in neural crest cells during embryonic development. acts as surface receptor that triggers tyrosine phosphorylation of fyn and ptk2, and a transient increase in the intracellular calcium concentration.
21090	
21091	plays an important role in the regulation of glutamine catabolism.
21092	
21093	
21094	
21095	
21096	
21097	possesses a trypsin-like cleavage specificity (by similarity).
21098	
21099	
21100	
21101	
21102	
21103	necessary for efficient rna polymerase ii transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by s-ii allows the resumption of elongation from the new 3@#$%&terminus.
21104	
21105	
21106	may be involved in assembly and membrane stacking of the golgi cisternae, and in the process by which golgi stacks reform after mitotic breakdown. may regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane tgfa.
21107	
21108	
21109	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
21110	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. socs5 is involved in regulating t-helper cell differentiation by inhibition of the il4 signaling pathway which promotes differentiation into the th2 phenotype. can also partially inhibit il6 and lif signaling (by similarity).
21111	component of the nuclear body, also known as nuclear domain 10, pml oncogenic domain, and kr body. may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.
21112	promotes the exchange of gdp by gtp (by similarity).
21113	
21114	
21115	does not act as an allosteric activator of the cholera toxin catalytic subunit. component of a regulated secretory pathway involved in ca(2+)-dependent release of acetylcholine.
21116	
21117	
21118	
21119	
21120	
21121	
21122	seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. may play a role in receptor clustering and cytoskeletal polarity in the junction between t- cell and antigen-presenting cell. may anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus.
21123	
21124	
21125	
21126	
21127	
21128	type i collagen is a member of group i collagen (fibrillar forming collagen).
21129	
21130	
21131	implicated as a tumor suppressor. may have a function in vesicular transport. interaction between hamartin and tuberin may facilitate vesicular docking.
21132	probable atpase involved in the assembly or function of nuclear protein complexes. may also be involved in some aspects of microtubule dynamics (by similarity).
21133	
21134	muscle contraction.
21135	
21136	
21137	may play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.
21138	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
21139	
21140	
21141	type i collagen is a member of group i collagen (fibrillar forming collagen).
21142	
21143	non-specific receptor for endothelin 1, 2, and 3. mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system.
21144	
21145	
21146	
21147	binds calmodulin in a calcium dependent manner. may function as scaffolding or signaling protein.
21148	
21149	
21150	
21151	
21152	
21153	catalyzes the conversion of gamma-aminobutyrate and l- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. can also convert delta-aminovalerate and beta-alanine.
21154	
21155	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
21156	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
21157	transcription factor, probably binds to the inverted palindrome 5@#$%&-gttaatnattaac-3@#$%&.
21158	
21159	
21160	
21161	may antagonize nodal signaling and subsequent organization of axial structures during mesodermal patterning (by similarity).
21162	
21163	
21164	
21165	complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. may form part of a tissue- specific acute response to remodeling stimuli. known to act on mmp-1, mmp-2, mmp-3, mmp-7, mmp-9, mmp-13, mmp-14 and mmp-15.
21166	not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
21167	conversion of sulfated steroid precursors to estrogens during pregnancy.
21168	
21169	
21170	
21171	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
21172	
21173	
21174	may belong to a complex displaying n-terminal acetyltransferase activity (by similarity).
21175	
21176	
21177	transcriptional activator which binds to the enhancer of the t-cell receptor alpha and delta genes. binds to the consensus sequence 5@#$%&-agatag-3@#$%&.
21178	
21179	collagen vi acts as a cell-binding protein.
21180	
21181	
21182	
21183	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
21184	
21185	
21186	
21187	
21188	
21189	
21190	
21191	
21192	
21193	
21194	
21195	
21196	
21197	
21198	
21199	
21200	
21201	
21202	tumor-associated antigen.
21203	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
21204	
21205	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
21206	
21207	
21208	
21209	
21210	
21211	
21212	
21213	
21214	
21215	
21216	
21217	binds to g-rich structures in 28s rrna and in mrnas. plays a regulatory role in the translation apparatus; inhibits cell-free translation of mrnas.
21218	important modulator in the hla class ii restricted antigen presentation pathway by interaction with the hla-dm molecule.
21219	
21220	
21221	
21222	
21223	
21224	
21225	
21226	
21227	
21228	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
21229	
21230	
21231	
21232	probably involved in membrane protein trafficking (by similarity).
21233	
21234	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
21235	
21236	
21237	
21238	
21239	may be involved in transcriptional regulation.
21240	component of the nua4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. the nua4 complex atpase and helicase activities seem to be, at least in part, contributed by the association of ruvbl1 and ruvbl2 with ep400. nua4 may also play a direct role in dna repair when directly recruited to sites of dna damage. also component of the msin3a complex which acts to repress transcription by deacetylation of nucleosomal histones.
21241	negatively regulates tyrosine hydroxylase activity.
21242	
21243	
21244	required for meiotic chromosome synapsis and cell cycle progression. may act as a molecular zipper to bring homologous chromosomes in close apposition. zip1 may encode the transverse filaments of the synaptonemal complex.
21245	
21246	
21247	
21248	
21249	
21250	
21251	
21252	
21253	phosphorylates microtubule-associated protein 2 (map2). may promote entry in the cell cycle (by similarity).
21254	suggested to be involved in kindling epileptogenesis and hippocampal plasticity. has a strong proteolytic activity against fibronectin (by similarity).
21255	mediates the nuclear export of proteins (cargos) with broad substrate specificity. in the nucleus binds cooperatively to its cargo and to the gtpase ran in its active gtp-bound form. docking of this trimeric complex to the nuclear pore complex (npc) is mediated through binding to nucleoporins. upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of ran-gtp to ran-gdp (induced by ranbp1 and rangap1, respectively) cause release of the cargo from the export receptor. xpo4 then return to the nuclear compartment and mediate another round of transport. the directionality of nuclear export is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus.
21256	required for assembly and activity of the vacuolar atpase. potential role in differential targeting and regulation of the enzyme for a specific organelle (by similarity).
21257	may be involved in n-glycosylation through its association with n-oligosaccharyl transferase.
21258	
21259	type xii collagen interacts with type i collagen- containing fibrils, the col1 domain could be associated with the surface of the fibrils, and the col2 and nc3 domains may be localized in the perifibrillar matrix (by similarity).
21260	
21261	
21262	
21263	fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, dna, and actin. fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. interaction with tnr mediates inhibition of cell adhesion and neurite outgrowth (by similarity).
21264	
21265	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
21266	
21267	probably involved in nervous system development and function.
21268	
21269	
21270	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
21271	
21272	
21273	in the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (krtap), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. the matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
21274	
21275	
21276	orphan receptor.
21277	
21278	in the nervous system, could hydrolyze atp and other nucleotides to regulate purinergic neurotransmission. could also be implicated in the prevention of platelet aggregation. hydrolyzes atp and adp equally well.
21279	
21280	
21281	major acute phase reactant. apolipoprotein of the hdl complex.
21282	dorsalizing factor. key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing tgf-beta family bone morphogenetic proteins (bmps) and sequestering them in latent complexes (by similarity).
21283	
21284	
21285	
21286	converts specific uridines to psi in a number of trna substrates. acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing trna. involved in regulation of nuclear receptor activity possibly through pseudouridylation of sra1 rna (by similarity).
21287	
21288	sodium-independent, high-affinity transport of large neutral amino acids. involved in cellular amino acid uptake.
21289	
21290	
21291	
21292	stimulates adenylate cyclase in pituitary cells.
21293	may be involved in transcriptional regulation.
21294	
21295	
21296	it may serve as a negative regulator of t-cell receptor (tcr) signaling via inhibition of calcineurin. interacts with and inhibits calcineurin-mediated signal transduction. cabin 1 is specific for the activated form of calcineurin, their interaction is dependent on both pkc and calcium signals.
21297	
21298	
21299	may serve as dna-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
21300	
21301	
21302	
21303	
21304	involved in sperm motility. its absence is associated with genetic background dependent male infertility. infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (by similarity).
21305	
21306	catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in rab proteins with an -xxcc, -xcxc and -ccxx c-terminal, such as rab1a, rab3a and rab5a respectively.
21307	guanine-nucleotide-releasing protein that acts on members of the sce4/ypt1/rab subfamily. stimulates gdp release from both ypt1 and rab3a, but is less active on these proteins than on the sec4 protein. might play a general role in vesicular transport.
21308	lysophoshatidylglycerol (lpg) specific acyltransferase that recognizes various acyl-coas and lpgs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-coas and oleoyl-coa as acyl donors. prefers oleoyl-lpg over palmitoyl-lpg as an acyl receptor and oleoyl-coa over lauroyl-coa as an acyl donor.
21309	involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. mediates its effects by interactions with a number of other regulators of apoptosis. isoform 1 inhibits apoptosis while isoform 2 promotes it.
21310	involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. mediates its effects by interactions with a number of other regulators of apoptosis. isoform 1 inhibits apoptosis while isoform 2 promotes it.
21311	
21312	
21313	
21314	serine protease that shows proteolytic activity against a nonspecific substrate beta-casein. promotes or induces cell death either by direct binding to and inhibition of birc proteins (also called inhibitor of apoptosis proteins, iaps), leading to an increase in caspase activity, or by a birc inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. isoform 2 seems to be proteolytically inactive.
21315	calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction.
21316	type i collagen is a member of group i collagen (fibrillar forming collagen).
21317	may play a role in the control of gene expression.
21318	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form.
21319	
21320	receptor for oxytocin. the activity of this receptor is mediated by g proteins which activate a phosphatidylinositol- calcium second messenger system.
21321	
21322	
21323	supplies the nucleotide substrate for thymidylate synthetase.
21324	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. binds poly(rg).
21325	
21326	may facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery.
21327	
21328	
21329	may function in the secretion of milk-fat droplets. may act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (by similarity).
21330	srf is a transcription factor that binds to the serum response element (sre), a short sequence of dyad symmetry located 300 bp to the 5@#$%& of the site of transcription initiation of some genes (such as fos).
21331	could be involved in cell-cell interactions.
21332	
21333	amidohydrolase that hydrolyzes specifically one of the carboamide linkages in d-pantetheine thus recycling pantothenic acid (vitamin b5) and releasing cysteamine.
21334	
21335	acts as a positive regulator of apoptosis.
21336	
21337	
21338	
21339	
21340	
21341	involved in the splicing process and participates in early heat shock-induced splicing arrest. due to their great structural variations the different isoforms may possess different functions in the splicing reaction.
21342	muscle contraction.
21343	may play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage.
21344	
21345	does not act as an allosteric activator of the cholera toxin catalytic subunit (by similarity).
21346	
21347	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling (by similarity).
21348	atp-dependent rna helicase (potential).
21349	
21350	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
21351	
21352	
21353	could regulate proteolytic events associated with testicular germ cell maturation.
21354	
21355	
21356	
21357	
21358	conversion of sulfated steroid precursors to estrogens during pregnancy.
21359	probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. can be blocked by extracellular barium and cesium.
21360	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems. g(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. may be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.
21361	may function as a transcription factor. seems to repress transcription.
21362	
21363	essential component of the nuclear pore complex. the n- terminal is probably involved in nucleocytoplasmic transport. the c-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex.
21364	may function in the process of apoptosis.
21365	may antagonize nodal signaling and subsequent organization of axial structures during mesodermal patterning (by similarity).
21366	this protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.
21367	
21368	
21369	platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. binding of this growth factor to its affinity receptor elicits a variety of cellular responses. it is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heal the wound.
21370	adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. alpha adaptin is a subunit of the plasma membrane adaptor. binds polyphosphoinositides (by similarity).
21371	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
21372	transcriptional activator that binds to dna sequences containing the consensus 5@#$%&-wgga-3@#$%&. transactivates promoters of the hematopoietic growth factor genes csf2, il3, il8, and of the bovine lysozyme gene. acts synergistically with runx1 to transactivate the il3 promoter. also transactivates the prf1 promoter in natural killer (nk) cells. plays a role in the development and function of nk and nk t-cells and in innate immunity.
21373	
21374	
21375	high affinity receptor for activated thrombin coupled to g proteins that stimulate phosphoinositide hydrolysis.
21376	
21377	
21378	
21379	
21380	receptor for members of the ephrin-a family. binds to ephrin-a1, -a2, -a3, -a4 and -a5.
21381	
21382	
21383	
21384	
21385	transcription factor that binds preferentially to a variant of the octamer motif (5@#$%&-atgataat-3@#$%&) (by similarity).
21386	transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. potential role in g2/m cell cycle regulation (by similarity).
21387	
21388	probable serine hydrolase. may be related to cell muscle hypertrophy.
21389	
21390	
21391	may be involved in transcriptional regulation.
21392	
21393	type i collagen is a member of group i collagen (fibrillar forming collagen).
21394	
21395	
21396	
21397	
21398	
21399	
21400	
21401	required for the accumulation of coenzyme a in the mitochondrial matrix.
21402	
21403	
21404	
21405	
21406	
21407	
21408	
21409	
21410	
21411	
21412	hgf is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. it has no detectable protease activity.
21413	
21414	
21415	
21416	
21417	
21418	
21419	
21420	
21421	
21422	
21423	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
21424	
21425	
21426	
21427	
21428	
21429	cbf binds to the core site, 5@#$%&-pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, lck, il-3 and gm-csf promoters. the alpha subunit binds dna and appears to have a role in the development of normal hematopoiesis. isoform aml-1l interferes with the transactivation activity of runx1. acts synergistically with elf4 to transactivate the il-3 promoter and with elf2 to transactivate the mouse blk promoter. inhibits myst4- dependent transcriptional activation.
21430	
21431	
21432	
21433	
21434	
21435	responsible for the deiodination of t4 (3,5,3@#$%&,5@#$%&- tetraiodothyronine) into t3 (3,5,3@#$%&-triiodothyronine). essential for providing the brain with appropriate levels of t3 during the critical period of development.
21436	
21437	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
21438	
21439	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
21440	
21441	
21442	
21443	
21444	dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. probably plays a central role at and after the meiotic phase of spermatogenesis (by similarity).
21445	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators.
21446	
21447	
21448	
21449	
21450	aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
21451	
21452	
21453	subunit of the splicing factor sf3a required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex.
21454	
21455	
21456	
21457	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
21458	carries out a dual function: signal transduction and activation of transcription. binds to the gas element and activates prl-induced transcription.
21459	
21460	
21461	
21462	
21463	
21464	
21465	may be involved in transcriptional regulation.
21466	
21467	displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosi and complement fixation through its calcium-dependent binding to phosphorylcholine. can interact with dna and histones and may scavenge nuclear material released from damaged circulating cells.
21468	
21469	
21470	plays a role as a transcriptional repressor during development. may play a role in the control of cell survival. overexpression of rere recruits bax to the nucleus particularly to pod and triggers caspase-3 activation, leading to cell death.
21471	active on amp and damp with atp as a donor. when gtp is used as phosphate donor, the enzyme phosphorylates amp, cmp, and to a small extent dcmp.
21472	
21473	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
21474	may function as a growth and differentiation factor involved in neuritogenesis. may induce erbb3 activation.
21475	
21476	
21477	
21478	
21479	probably involved in the control of the cell cycle. interacts with cyclins a, b3, d, or e. activity of cdk2 is maximal during s phase and g2.
21480	
21481	seems to act as a transcriptional repressor.
21482	
21483	receptor for brain-derived neurotrophic factor (bdnf), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (ngf). involved in the development and/or maintenance of the nervous system. this is a tyrosine-protein kinase receptor. known substrates for the trk receptors are shc1, pi-3 kinase, and plc- gamma-1.
21484	straight-chain enoyl-coa thioesters from c4 up to at least c16 are processed, although with decreasing catalytic rate.
21485	
21486	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis (by similarity).
21487	dorsalizing factor. key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing tgf-beta family bone morphogenetic proteins (bmps) and sequestering them in latent complexes (by similarity).
21488	
21489	may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.
21490	receptor for the hormone galanin. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity.
21491	
21492	may contribute to sister chromatid cohesion (by similarity).
21493	general activator of rna polymerase which utilizes different tfiiib complexes at structurally distinct promoters. the isoform 1 is involved in the transcription of trna, adenovirus va1, 7sl and 5s rna. isoform 2 is required for transcription of the u6 promoter.
21494	integrin alpha-x/beta-2 is a receptor for fibrinogen. it recognizes the sequence g-p-r in fibrinogen. it mediates cell-cell interaction during inflammatory responses. it is especially important in monocyte adhesion and chemotaxis.
21495	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
21496	
21497	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
21498	hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
21499	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
21500	may be involved in transcriptional regulation.
21501	converts lysophosphatidic acid (lpa) into phosphatidic acid by incorporating acyl moiety at the 2 position (by similarity).
21502	
21503	
21504	
21505	may play a role in an as yet undefined retina-specific signal transduction. could binds to photoactivated-phosphorylated red/green opsins.
21506	may eliminate potentially toxic dinucleoside polyphosphates during sporulation. most active against diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p6-hexaphosphate (ap6a). can also hydrolyze diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p5-pentaphosphate (ap5a), adenosine 5@#$%&-pentaphosphate, and adenosine 5@#$%&-tetraphosphate are also substrates, but not diadenosine 5@#$%&,5@#$%&@#$%&@#$%&-p1,p4-tetraphosphate (ap4a) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. also cleaves a beta-phosphate from the diphosphate groups in pp-insp5 (diphosphoinositol pentakisphosphate) and [pp]2-insp4 (bisdiphosphoinositol tetrakisphosphate).
21507	
21508	
21509	creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
21510	
21511	in vitro; can phosphorylate histones h3 and h2b on ser and thr residues. may be involved in the regulation of cellular growth and/or development.
21512	
21513	implicated in the genesis of hemopoietic malignancies. it may play an important role in hemopoietic differentiation. serves as a positive regulator of erythroid differentiation. binds to the lim domain containing protein rhombotin-2.
21514	guanine-nucleotide-releasing protein that acts on members of the sce4/ypt1/rab subfamily. stimulates gdp release from both ypt1 and rab3a, but is less active on these proteins than on the sec4 protein. might play a general role in vesicular transport.
21515	
21516	
21517	
21518	
21519	single stranded dna-dependent atp-dependent helicase. has a role in chromosome translocation. the dna helicase ii complex binds preferentially to fork-like ends of double-stranded dna in a cell cycle-dependent manner. it works in the 3@#$%&-5@#$%& direction. binding to dna may be mediated by p70. involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination. the ku p70/p86 dimer acts as regulatory subunit of the dna-dependent protein kinase complex dna-pk by increasing the affinity of the catalytic subunit prkdc to dna by 100-fold. the ku p70/p86 dimer is probably involved in stabilizing broken dna ends and bringing them together. the assembly of the dna-pk complex to dna ends is required for the nhej ligation step. in association with narg1, the ku p70/p86 dimer binds to the osteocalcin promoter and activates osteocalcin expression.
21520	
21521	
21522	
21523	
21524	acts as a transcriptional repressor. may play a role in limb-pattern formation. acts in cranofacial development and specifically in odontogenesis.
21525	necessary for cellular interactions with laminin and the extracellular matrix.
21526	endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. cleaves heparan sulfate proteoglycans (hspgs) into heparan sulfate side chains and core proteoglycans. also implicated in the extravasation of leukocytes and tumor cell lines. due to its contribution to metastasis and angiogenesis, it is considered to be a potential target for anti- cancer therapies.
21527	supplies the nucleotide substrate for thymidylate synthetase.
21528	
21529	
21530	
21531	may be involved in visual system development.
21532	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. the n-terminus interacts with and regulates xpd whereas an intact c- terminus is required for a successful escape of rnap ii form the promoter.
21533	
21534	may function in the secretion of milk-fat droplets. may act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (by similarity).
21535	
21536	srf is a transcription factor that binds to the serum response element (sre), a short sequence of dyad symmetry located 300 bp to the 5@#$%& of the site of transcription initiation of some genes (such as fos).
21537	prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
21538	not known; potential regulator of cellular growth.
21539	
21540	
21541	
21542	
21543	promote mitochondrial fission (by similarity).
21544	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
21545	
21546	
21547	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
21548	thought to be required for maintaining cell proliferation.
21549	
21550	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
21551	
21552	
21553	transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. potential role in g2/m cell cycle regulation (by similarity).
21554	morphine modulating peptides. have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. neuropeptide ff potentiates and sensitizes accn2 and accn3 channels.
21555	
21556	probable serine protease.
21557	this protein mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
21558	seems to be required for the activation of 5-lo (5- lipoxygenase). flap could play an essential role in the transfer of arachidonic acid to 5-lo. flap binds to mk-886, a compound that blocks the biosynthesis of leukotrienes.
21559	binds to heparin. induces cell attachment and spreading and plays a role in cell adhesion.
21560	
21561	binds to disheveled (dvl) and rho, and mediates wnt- induced dvl-rho complex formation. may play a role as a scaffolding protein to recruit rho-gdp and rho-gef, thereby, enhancing rho-gtp formation.
21562	may play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. may modulate sc6a1/gat1-mediated gaba uptake by stabilizing the transporter. required for localization of vil2 to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (by similarity).
21563	seems to act exclusively upon threonine residues (by similarity).
21564	
21565	as a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. recruits pip5k1c to focal adhesion plaques and strongly activates its kinase activity (by similarity).
21566	
21567	transcriptional repressor binding to promoters of vertebrate c-myc gene. also binds to the plk and pim1 promoters. may prevent the access of transcriptional activators to enhancers. also acts as a transcriptional activator of app. involved in different aspects of gene regulation including promoter activation or repression, hormone-responsive gene silencing, methylation- dependent chromatin insulation, and genomic imprinting. seems to act as tumor suppressor.
21568	
21569	
21570	gtpase-activating protein for the adp ribosylation factor family. may serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting pak1 to adhesions and the leading edge of lamellipodia. sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes.
21571	
21572	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
21573	
21574	could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. pro-apoptotic protein that functions intracellularly upstream of jnk activation and cytochrome c release.
21575	
21576	may be involved in transcriptional regulation.
21577	
21578	
21579	
21580	component of the asymmetric unit membrane (aum); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. may play an important role in aum-cytoskeleton interaction in terminally differentiated urothelial cells. it also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (by similarity).
21581	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
21582	
21583	could be a global transcriptional regulator. modifies gene expression by affecting chromatin. may be involved in brain development and facial morphogenesis.
21584	
21585	
21586	
21587	
21588	
21589	
21590	
21591	essential component of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. when overexpressed in cells induces the formation of cytoplasmic annulate lamellae (al) (by similarity).
21592	
21593	orphan receptor.
21594	muscle contraction.
21595	
21596	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
21597	
21598	
21599	
21600	
21601	
21602	
21603	
21604	recognizes and binds the 7-methylguanosine-containing mrna cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mrnas secondary structures.
21605	
21606	
21607	
21608	
21609	recognizes the ribosomal rna gene promoter and activates transcription mediated by rna polymerase i through cooperative interactions with the species-specific factor sl1. it binds specifically to the upstream control element.
21610	
21611	
21612	
21613	may be involved in transcriptional regulation.
21614	
21615	
21616	
21617	
21618	
21619	
21620	
21621	
21622	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
21623	mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons uaa and uag (by similarity).
21624	
21625	potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.
21626	
21627	
21628	
21629	
21630	
21631	
21632	
21633	
21634	
21635	
21636	
21637	
21638	signaling adapter that couples activated growth factor receptors to signaling pathway. isoform p46shc and isoform p52shc, once phosphorylated, couple activated receptor tyrosine kinases to ras via the recruitment of the grb2/sos complex and are implicated in the cytoplasmic propagation of mitogenic signals. isoform p46shc and isoform p52shc may thus function as initiators of the ras signaling cascade in various nonneuronal systems. isoform p66shc does not mediate ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. isoform p66shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. the expression of isoform p66shc has been correlated with life span (by similarity).
21639	
21640	potential guanine nucleotide exchange factor (gef). gef proteins activate some small gtpases by exchanging bound gdp for free gtp.
21641	
21642	
21643	
21644	
21645	
21646	probably involved in nervous system development and function.
21647	3beta-hsd is a bifunctional enzyme, that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. the 3beta-hsd enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
21648	
21649	forms a high-affinity link between the actin cytoskeleton and the membrane. isoform 2 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation.
21650	
21651	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
21652	
21653	
21654	
21655	cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions (by similarity).
21656	
21657	
21658	
21659	
21660	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
21661	fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly.
21662	involved in transport factor (ran-gtp, karyopherin)- mediated protein import via the f-g repeat-containing domain which acts as a docking site for substrates. could also have isomerase or chaperone activity and may bind rna or dna. component of the nuclear export pathway. specific docking site for the nuclear export factor exportin-1.
21663	required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
21664	binds dna as a heterodimer with max and represses transcription. binds to the canonical e box sequence 5@#$%&-cacgtg-3@#$%& and, with higher affinity, to 5@#$%&-cacgcg-3@#$%&.
21665	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
21666	
21667	
21668	palmitoyltransferase specific for vac8. palmitoylates vac8 at one or more of its n-terminal cysteine residues, which is required for its proper membrane localization.
21669	
21670	
21671	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
21672	
21673	
21674	
21675	
21676	
21677	
21678	
21679	
21680	
21681	hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
21682	implicated in immunoproteasome assembly and required for efficient antigen processing. the pa28 activator complex enhances the generation of class i binding peptides by altering the cleavage pattern of the proteasome.
21683	
21684	probable immunoglobulin-like cell surface receptor.
21685	
21686	may be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors (potential).
21687	
21688	this isozyme may play a role in skeletal mineralization.
21689	
21690	responsible for the synthesis of complex-type n-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. can produce lactose.
21691	
21692	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
21693	catalyzes the initial reaction in o-linked oligosaccharide biosynthesis, the transfer of an n-acetyl-d- galactosamine residue to a serine or threonine residue on the protein receptor. has a broad spectrum of substrates for peptides such as ea2, muc5ac, muc1a, muc1b. probably involved in o-linked glycosylation of the immunoglobulin a1 (iga1) hinge region.
21694	
21695	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems. g(k) is the stimulatory g protein of receptor- regulated k(+) channels.
21696	bifunctional subunit.
21697	inhibitory regulator of the ras-cyclic amp pathway. binds inositol tetrakisphosphate (ip4).
21698	
21699	
21700	histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). in addition, histatins exhibit antibacterial and antifungal activities.
21701	
21702	replaces conventional h2a in a subset of nucleosomes. may be involved in the formation of constitutive heterochromatin. may be required for chromosome segregation during cell division.
21703	
21704	
21705	
21706	
21707	may play a role in cell-cell and cell-matrix interactions. may contribute to various neuronal mechanisms in the central nervous system.
21708	hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
21709	
21710	calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. is not activated by phorbol esters or diaglycerol. may play a role in the secretory response to nutrients. involved in cell polarization processes and the formation of epithelial tight junctions.
21711	important modulator in the hla class ii restricted antigen presentation pathway by interaction with the hla-dm molecule.
21712	
21713	
21714	catalyzes the addition of n-acetylglucosamine in beta 1- 6 linkage to the alpha-linked mannose of biantennary n-linked oligosaccharides. it is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.
21715	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
21716	
21717	
21718	may have an important role in presynaptic function. may be involved in calcium-dependent neurotransmitter release at nerve endings (by similarity).
21719	likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. capable of cleavage at the rx(k/r)r consensus motif.
21720	calcium-dependent mitochondrial solute carrier (by similarity).
21721	could be involved in the hypothalamic regulation of body weight.
21722	
21723	
21724	the epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.
21725	not known.
21726	sequence-specific transcriptional activator. recognizes the dna sequence 5@#$%&-c[ca]ggaagt-3@#$%&.
21727	hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. does not have reverse activity.
21728	can transform nih 3t3 cells from a human stomach tumor (hst) and from karposi@#$%&s sarcoma (ks3). it has a mitogenic activity.
21729	helicase; has atpase activity.
21730	
21731	suppressor of apoptosis.
21732	
21733	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. this receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system. this receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.
21734	functions in the early steps of protein synthesis by forming a ternary complex with gtp and initiator trna. this complex binds to a 40s ribosomal subunit, followed by mrna binding to form a 43s preinitiation complex. junction of the 60s ribosomal subunit to form the 80s initiation complex is preceded by hydrolysis of the gtp bound to eif-2 and release of an eif-2-gdp binary complex. in order for eif-2 to recycle and catalyze another round of initiation, the gdp bound to eif-2 must exchange with gtp by way of a reaction catalyzed by eif-2b.
21735	
21736	may be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.
21737	transcriptional repressor binding to promoters of vertebrate c-myc gene. also binds to the plk and pim1 promoters. may prevent the access of transcriptional activators to enhancers. also acts as a transcriptional activator of app. involved in different aspects of gene regulation including promoter activation or repression, hormone-responsive gene silencing, methylation- dependent chromatin insulation, and genomic imprinting. seems to act as tumor suppressor.
21738	
21739	
21740	
21741	required for proper activation of rho gtpases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via nmda receptors. non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (paf) by removing the acetyl group at the sn-2 position (by similarity). positively regulates the activity of the minus-end directed microtubule motor protein dynein. may enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. required for several dynein- and microtubule-dependent processes such as the maintenace of golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. during nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. may also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.
21742	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters.
21743	
21744	
21745	
21746	
21747	recognizes and binds the palindromic sequence 5@#$%&- ttggcnnnnngccaa-3@#$%& present in viral and cellular promoters and in the origin of replication of adenovirus type 2. these proteins are individually capable of activating transcription and replication.
21748	
21749	has a role in maintaining calcium homeostasis. catalyzes the nadph-dependent 24-hydroxylation of 25-hydroxyvitamin d(3) in the presence of adrenodoxin and nadph-adrenodoxin reductase.
21750	
21751	unknown.
21752	the s.cerevisiae ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-amp.
21753	
21754	
21755	
21756	
21757	
21758	may be involved in spermatogenesis.
21759	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules.
21760	
21761	
21762	
21763	
21764	
21765	
21766	
21767	may be involved in transcriptional regulation.
21768	
21769	
21770	
21771	
21772	inhibitory effect on stress fiber organization. may down-regulate rho-like gtpase in hematopoietic cells.
21773	
21774	
21775	
21776	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
21777	
21778	
21779	may be a regulated effector of stress granule assembly. phosphorylation-dependent sequence-specific endoribonuclease in vitro. cleaves exclusively between cytosine and adenine and cleaves c-myc mrna preferentially at the 3@#$%&utr. atp- and magnesium-dependent helicase. unwinds preferentially partial dna and rna duplexes having a 17 bp annealed portion and either a hanging 3@#$%& tail or hanging tails at both 5@#$%& and 3@#$%& ends. unwinds dna/dna, rna/dna, and rna/rna substrates with comparable efficiency. acts unidirectionally by moving in the 5@#$%& to 3@#$%& direction along the bound single-stranded dna.
21780	tumor-associated antigen.
21781	
21782	
21783	
21784	may be involved in transcriptional regulation.
21785	may be involved in transcriptional regulation.
21786	
21787	
21788	
21789	
21790	
21791	involved in transport of phospholipids (potential).
21792	
21793	
21794	
21795	
21796	
21797	
21798	
21799	
21800	
21801	
21802	
21803	
21804	
21805	
21806	
21807	
21808	this proteoglycan is a major component of extracellular matrix of cartilagenous tissues. a major function of this protein is to resist compression in cartilage. it binds avidly to hyaluronic acid via an n-terminal globular region.
21809	
21810	
21811	
21812	
21813	nmda receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine.
21814	
21815	
21816	
21817	
21818	
21819	
21820	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
21821	
21822	may be involved in transcriptional regulation.
21823	
21824	
21825	
21826	involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. may represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. interacts with the sh2 domain of grb2. may phosphorylate the voltage-gated potassium channel protein kv1.2. its activation is highly correlated with the stimulation of c-jun n-terminal kinase activity.
21827	may act as a gtpase activating protein for rab family protein(s) (potential).
21828	
21829	f-actin capping proteins bind in a ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
21830	
21831	
21832	
21833	
21834	required for the uptake of taurine.
21835	part of the complex catalyzing the transfer of n- acetylglucosamine from udp-n-acetylglucosamine to phosphatidylinositol, the first step of gpi biosynthesis.
21836	
21837	
21838	general protein kinase capable of phosphorylating several known proteins.
21839	it may serve as a negative regulator of t-cell receptor (tcr) signaling via inhibition of calcineurin. interacts with and inhibits calcineurin-mediated signal transduction. cabin 1 is specific for the activated form of calcineurin, their interaction is dependent on both pkc and calcium signals.
21840	involved in the biosynthesis of gangliosides gm2, gd2 and ga2.
21841	
21842	
21843	
21844	
21845	regulator of notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. probably acts both as a positive and negative regulator of notch, depending on the developmental and cell context (by similarity). functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the notch pathway via some ubiquitin ligase activity.
21846	
21847	
21848	this protein is a component of ribonucleosomes. could be needed to organize a concentration gradient of a dorsalizing morphogen (dm) originating in the germinal vesicle. at least one of the isoforms is essential in somatic tissues.
21849	promotes neurite outgrowth of both axons and dendrites (by similarity).
21850	
21851	probably plays a role in the development of the brain and the sense organs. can bind to the bcd target sequence (bts): 5@#$%&-tctaatccc-3@#$%&.
21852	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation via its interaction with the myocyte enhancer factors such as mef2a, mef2c and mef2d.
21853	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation via its interaction with the myocyte enhancer factors such as mef2a, mef2c and mef2d.
21854	
21855	
21856	
21857	
21858	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
21859	plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. this phosphodiesterase is highly specific for camp and may have a role in muscle signal transduction.
21860	could be a global transcriptional regulator. modifies gene expression by affecting chromatin. may be involved in brain development and facial morphogenesis.
21861	interacts strongly with cdk4 and cdk6. potent inhibitor. potential effector of tgf-beta induced cell cycle arrest.
21862	
21863	this protein binds the camp response element (cre), a sequence present in many viral and cellular promoters. crem alpha, beta, and gamma isoforms are antagonists of the camp transcriptional response, while the delta isoform is an activator.
21864	
21865	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
21866	
21867	
21868	
21869	
21870	
21871	
21872	
21873	
21874	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
21875	
21876	converts multiple adenosines to inosines and creates i/u mismatched base pairs in double-helical rna substrates without apparent sequence specificity. has been found to modify more frequently adenosines in au-rich regions, probably due to the relative ease of melting a/u base pairs as compared to g/c pairs. functions to modify viral rna genomes and may be responsible for hypermutation of certain negative-stranded viruses. edits the messenger rnas for glutamate receptor (glur) subunits by site- selective adenosine deamination. produces low-level editing at the glur-b q/r site, but edits efficiently at the r/g site and hotspot1. binds to short interfering rnas (sirna) without editing them and suppresses sirna-mediated rna interference. binds to ilf3/nf90 and upregulates ilf3-mediated gene expression.
21877	essential for vacuolar protein sorting. function in membrane traffic between the golgi and the vacuole.
21878	inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. inhibits degradation of mdm2. can reverse mdm2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions.
21879	activates the small gtpases arf1, arf5 and arf6. regulates the formation of post-golgi vesicles and modulates constitutive secretion. modulates phagocytosis mediated by fc gamma receptor and arf6. modulates pxn recruitment to focal contacts and cell migration.
21880	
21881	probable transcription factor associated with development of alveolar rhabdomyosarcoma.
21882	not known, associated with cell differentiation.
21883	
21884	transcriptional repressor that play an important role in the specification and differentiation of lung epithelium.
21885	
21886	
21887	may be involved in transcriptional regulation.
21888	
21889	
21890	synthesis and degradation of fructose 2,6-bisphosphate.
21891	electroneutral sodium- and bicarbonate-dependent cotransporter with a na(+):hco3(-) 1:1 stoichiometry. regulates intracellular ph and may play a role in bicarbonate salvage in secretory epithelia. may also have an associated sodium channel activity.
21892	muscle contraction.
21893	
21894	
21895	serum albumin, the main protein of plasma, has a good binding capacity for water, ca(2+), na(+), k(+), fatty acids, hormones, bilirubin and drugs. its main function is the regulation of the colloidal osmotic pressure of blood.
21896	
21897	
21898	involved in cannabinoid-induced cns effects. acts by inhibiting adenylate cyclase. could be a receptor for anandamide. isoform 2 and isoform 3 have altered ligand binding.
21899	
21900	
21901	
21902	
21903	
21904	
21905	attaches integral membrane proteins to cytoskeletal elements. also binds to cytoskeletal proteins. required for coordinate assembly of na/ca exchanger, na/k atpase and insp3 receptor at sarcoplasmic reticulum sites in cardiomyocytes.
21906	
21907	
21908	belongs to the 26s multisubunit protease, which is required for ubiquitin-dependent proteolysis. does not bind ubiquitin polymers.
21909	collagen type iv is specific for basement membranes.
21910	a rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (erc) to the plasma membrane. also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (ptdinsp3) and phosphatidic acid (pa).
21911	
21912	receptor for neuropeptide y and peptide yy. the rank order of affinity of this receptor for pancreatic polypeptides is pp, pp (2-36) and [ile-31, gln-34] pp > [pro-34] pyy > pyy and [leu-31, pro-34] npy > npy > pyy (3-36) and npy (2-36) > pp (13- 36) > pp (31-36) > npy free acid.
21913	
21914	
21915	may participate in regulatory interactions between microtubules and the cell cycle.
21916	may act as a receptor in regulating t-cell proliferation. cd5 interacts with cd72/lyb-2.
21917	
21918	
21919	tumor suppressor that may be involved in interferon- dependent cell death (by similarity).
21920	
21921	
21922	receptor for tnfsf2/tnf-alpha and homotrimeric tnfsf1/lymphotoxin-alpha. the adapter molecule fadd recruits caspase-8 to the activated receptor. the resulting death-inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. contributes to the induction of noncytocidal tnf effects including anti-viral state and activation of the acid sphingomyelinase.
21923	
21924	regulates myosin phosphatase activity.
21925	promotes the exchange of gsp1/gsp2-bound gdp by gtp. involved in yeast pheromone response pathway and in mrna metabolism. probably involved in the control of nuclear organization.
21926	snare involved in a vesicular transport step within the golgi stack.
21927	promotes adhesion of endothelial cells through interaction of integrins and the rgd motif. could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling.
21928	ca(2+)-dependent modulation of synaptic efficacy.
21929	
21930	scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. necessary for camp-mediated phosphorylation and inhibition of slc9a3. may also act as scaffold protein in the nucleus.
21931	may be involved in transcriptional regulation.
21932	
21933	
21934	
21935	appears to have dual functions such as cytoplasmic retention of attached nf-kappa-b proteins and generation of p50 by a cotranslational processing. the proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of nfkb1/p105 also appears to occur posttranslationally. p50 binds to the kappa-b consensus sequence 5@#$%&-ggrnnyycc-3@#$%&, located in the enhancer region of genes involved in immune response and acute phase reactions. plays a role in the regulation of apoptosis.
21936	
21937	
21938	
21939	
21940	suppressor of clathrin deficiency.
21941	
21942	heterodimers between tcf3 and tissue-specific basic helix-loop-helix (bhlh) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early b-cell differentiation. dimers bind dna on e-box motifs: 5@#$%&- canntg-3@#$%&. binds to the kappa-e2 site in the kappa immunoglobulin gene enhancer.
21943	
21944	responsible for the synthesis of complex-type n-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
21945	
21946	
21947	
21948	transcription activator for a number of liver genes such as afp, albumin, tyrosine aminotransferase, pepck, etc. interacts with the cis-acting regulatory regions of these genes.
21949	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
21950	
21951	
21952	terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. may play a role in regulation of glycine levels in nmda receptor-mediated neurotransmission.
21953	
21954	critical component of the membrane-bound oxidase of phagocytes that generates superoxide. it is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic nadph across the plasma membrane to molecular oxygen on the exterior. also functions as a voltage-gated proton channel that mediates the h(+) currents of resting phagocytes. it participates in the regulation of cellular ph and is blocked by zinc.
21955	binds to the receptor tyrosine kinases ephb1 and epha1. binds to, and induce the collapse of, commissural axons/growth cones in vitro. may play a role in constraining the orientation of longitudinally projecting axons (by similarity).
21956	
21957	
21958	
21959	
21960	
21961	major component of the descemet membrane (basement membrane) of corneal endothelial cells.
21962	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
21963	binds medium- and long-chain acyl-coa esters with very high affinity and may function as an intracellular carrier of acyl-coa esters (by similarity).
21964	
21965	microtubule-binding motor protein probably involved in neuronal axonal transport. in vitro, has a plus-end directed motor activity (by similarity).
21966	could regulate beta-glucan synthesis. overexpression provides resistance to hm-1 killer toxin.
21967	
21968	
21969	
21970	
21971	tumor-associated antigen.
21972	
21973	
21974	
21975	
21976	
21977	
21978	integrin alpha-x/beta-2 is a receptor for fibrinogen. it recognizes the sequence g-p-r in fibrinogen. it mediates cell-cell interaction during inflammatory responses. it is especially important in monocyte adhesion and chemotaxis.
21979	
21980	putative transcription activator that may function in lymphoid development and oncogenesis. binds, in vitro, to double- stranded dna.
21981	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
21982	
21983	
21984	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
21985	
21986	type i collagen is a member of group i collagen (fibrillar forming collagen).
21987	
21988	
21989	regulates the gdp/gtp exchange reaction of the rho proteins by inhibiting the dissociation of gdp from them, and the subsequent binding of gtp to them (by similarity).
21990	
21991	
21992	
21993	
21994	
21995	may be involved in transcriptional regulation.
21996	
21997	
21998	
21999	
22000	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.
22001	strong transcriptional activator; dna-binding protein that specifically recognize the sequence 5@#$%&-yaac[gt]g-3@#$%&. could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and b-lymphoid cells.
22002	
22003	
22004	
22005	
22006	
22007	may be involved in cell-cell interactions and recognition.
22008	
22009	
22010	
22011	
22012	
22013	
22014	
22015	
22016	
22017	
22018	
22019	transcriptional inhibitor that binds to dna sequence 5@#$%&- cacct-3@#$%& in different promoters (by similarity).
22020	
22021	receptor for a c-c type chemokine. binds to eotaxin, eotaxin-3, mcp-3, mcp-4, rantes and mip-1 delta. subsequently transduces a signal by increasing the intracellular calcium ions level. alternative coreceptor with cd4 for hiv-1 infection.
22022	
22023	
22024	
22025	
22026	
22027	
22028	
22029	
22030	
22031	
22032	
22033	
22034	
22035	binds to tie2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. its function may be context-dependent. in the absence of angiogenic inducers, such as vegf, ang2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. in concert with vegf, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
22036	
22037	
22038	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator.
22039	calcium-dependent mitochondrial aspartate and glutamate carrier. may have a function in the urea cycle.
22040	electroneutral sodium- and bicarbonate-dependent cotransporter with a na(+):hco3(-) 1:1 stoichiometry. regulates intracellular ph and may play a role in bicarbonate salvage in secretory epithelia. may also have an associated sodium channel activity.
22041	
22042	
22043	
22044	may play a role in the specification of neuronal cell types.
22045	may function in cell cycle regulation.
22046	
22047	
22048	
22049	may act as a regulator of synaptic vesicle exocytosis by controlling the availability of snap25 for the snare complex formation (by similarity).
22050	
22051	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
22052	
22053	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
22054	necessary for the catabolism of n-linked carbohydrates released during glycoprotein turnover. cleaves all known types of alpha-mannosidic linkages.
22055	
22056	
22057	cytokine that drives rapid clonal expansion of naive but not memory cd4(+) t-cells. it also strongly synergizes with il-12 to trigger ifn-gamma production of naive cd4(+) t-cells. mediates its biologic effects through the cytokine receptor wsx-1/tccr.
22058	involved in maintaining the transcriptionally repressive state of genes. modifies chromatin, rendering it heritably changed in its expressibility (by similarity).
22059	
22060	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
22061	
22062	
22063	
22064	nuclease that induces dna fragmentation and chromatin condensation during apoptosis. degrades naked dna and induces apoptotic morphology.
22065	
22066	
22067	binds gtp, gdp and gmp.
22068	trafficking protein from a constitutively recycling pathway (by similarity).
22069	promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including vega-a, vega-c, mmp1, mmp3, timp1, upa, pai-1 and integrins alpha-3 and alpha-5. cyr61-mediated gene regulation is dependent on heparin-binding. down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
22070	
22071	
22072	
22073	
22074	
22075	
22076	
22077	type i collagen is a member of group i collagen (fibrillar forming collagen).
22078	regulates intra- and extracellular levels of inorganic pyrophosphate (ppi), probably functioning as ppi transporter.
22079	this protein is a component of ribonucleosomes.
22080	
22081	binds to the 23s rrna (by similarity).
22082	component of the large subunit of mitochondrial ribosome (potential).
22083	
22084	transcription activator for a number of liver genes such as afp, albumin, tyrosine aminotransferase, pepck, etc. interacts with the cis-acting regulatory regions of these genes.
22085	
22086	
22087	
22088	
22089	
22090	
22091	
22092	
22093	
22094	interacts with the viral protein-binding domain of the retinoblastoma protein.
22095	
22096	may modulate the internalization of beta-amyloid precursor protein.
22097	
22098	
22099	
22100	
22101	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes (by similarity).
22102	transcriptional repressor; binds to the dna sequence 5@#$%&- ccggaagt-3@#$%&.
22103	may be a regulatory site in cholesterol biosynthetic pathway.
22104	required for the expression of several liver specific genes. binds to the inverted palindrome 5@#$%&-gttaatnattaac-3@#$%&.
22105	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
22106	
22107	involved in embryogenesis and cell differentiation.
22108	
22109	controls reversibly actin polymerization and depolymerization in a ph-sensitive manner. it has the ability to bind g- and f-actin in a 1:1 ratio of cofilin to actin. it is the major component of intranuclear and cytoplasmic actin rods (by similarity).
22110	
22111	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (by similarity).
22112	necessary for centrosome duplication.
22113	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&. activates transcription of pf4 in complex with meis1.
22114	
22115	
22116	catalyzes the deacetylation of n-acetylaspartic acid (naa) to produce acetate and l-aspartate. naa occurs in high concentration in brain and its hydrolysis naa plays a significant part in the maintenance of intact white matter. in other tissues it act as a scavenger of naa from body fluids.
22117	
22118	
22119	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
22120	
22121	
22122	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis. regulates the ca(2+)- dependent secretion of norepinephrine in pc12 cells. required for export from the endocytic recycling compartment to the cell surface (by similarity).
22123	
22124	cell surface proteoglycan that bears heparan sulfate.
22125	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
22126	
22127	
22128	
22129	inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the e1 alpha subunit, thus contributing to the regulation of glucose metabolism.
22130	
22131	
22132	
22133	
22134	regulates synaptic membrane exocytosis (by similarity).
22135	
22136	
22137	probably involved in the repair of mismatches in dna.
22138	
22139	
22140	
22141	this protein is a component of ribonucleosomes.
22142	
22143	
22144	type i collagen is a member of group i collagen (fibrillar forming collagen).
22145	promotes guanine-nucleotide exchange on arf1, arf3 and arf6. promotes the activation of arf through replacement of gdp with gtp.
22146	receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5), susceptibility to infection is correlated to its level of expression and availability at the plasma membrane of cells.
22147	
22148	
22149	
22150	binds to splice sites in pre-mrna and regulates splice site selection. binds and stabilizes cytoplasmic mrna. contributes to the regulation of translation by modulating the interaction between the mrna and eukaryotic initiation factors (by similarity). binds to promoters that contain a y-box (5@#$%&- ctgattggccaa-3@#$%&), such as hla class ii genes. regulates the transcription of numerous genes. promotes separation of dna strands that contain mismatches or are modified by cisplatin. has endonucleolytic activity and can introduce nicks or breaks into double-stranded dna (in vitro). may play a role in dna repair.
22151	
22152	
22153	
22154	transcriptional factor which uses the canonical single or multiple carg boxes dna sequence. acts as a cofactor of serum response factor (srf) and has the potential to modulate srf-target genes. suppresses tnf-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. it may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (by similarity).
22155	
22156	binds directly to 26s ribosomal rna (by similarity).
22157	
22158	
22159	
22160	
22161	
22162	
22163	
22164	
22165	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii is composed of at least five proteins: the sec23/24 complex, the sec13/31 complex, and the protein sar1. acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex (by similarity).
22166	
22167	
22168	
22169	
22170	
22171	
22172	
22173	
22174	
22175	
22176	
22177	
22178	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins that stimulate adenylate cyclase. this receptor is implicated in the regulation of mammalian circadian rhythms.
22179	
22180	
22181	
22182	
22183	
22184	
22185	may be involved in transcriptional regulation.
22186	
22187	
22188	
22189	necessary for elongation and maintenance of stereocilia in the inner and outer hair cells in the organ of corti in the inner ear (by similarity).
22190	
22191	
22192	
22193	
22194	
22195	
22196	involved in the biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (moad).
22197	
22198	
22199	seems to act as a scaffold protein in multiple signaling pathways. modulates excitatory synaptic transmission and dendritic spine morphology. binds to actin filaments (f-actin) and shows cross-linking activity. binds along the sides of the f-actin. may play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. believed to target protein phosphatase 1/pp1 to dendritic spines, which are rich in f-actin, and regulates its specificity toward ion channels and other substrates, such as ampa-type and nmda-type glutamate receptors. plays a role in regulation of g-protein coupled receptor signaling, including dopamine d2 receptors and alpha- adrenergic receptors. may establish a signaling complex for dopaminergic neurotransmission through d2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. binds to adra1b and rgs2 and mediates regulation of adra1b signaling. may confer to rac signaling specificity by binding to both, racgefs and rac effector proteins. probably regulates p70 s6 kinase activity by forming a complex with tiam1.
22200	
22201	
22202	
22203	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
22204	neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
22205	involved in the presentation of foreign antigens to the immune system.
22206	
22207	plays a role in apoptosis. suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. binding of cytochrome c to apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
22208	
22209	
22210	sulfate transporter. may play a role in endochondral bone formation.
22211	heparin-binding protein, with mitogenic activity for fibroblasts.
22212	reversible hydration of carbon dioxide. its role in saliva is unknown.
22213	may be involved in transcriptional regulation.
22214	binds to the fc region of immunoglobulins gamma. low affinity receptor. by binding to igg it initiates cellular responses against pathogens and soluble antigens.
22215	
22216	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
22217	
22218	lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. it acts at a late stage of megakaryocyte development. it may be the major physiological regulator of circulating platelets.
22219	necessary for cellular interactions with laminin and the extracellular matrix.
22220	
22221	
22222	
22223	essential protein involved in the second catalytic step of pre-mrna splicing. involved in the selection of 3@#$%&l-type splice sites; this selection could be done via a 3@#$%& splice site-binding factor, prp16.
22224	
22225	
22226	
22227	down-regulates signaling from heterotrimeric g-proteins by increasing the gtpase activity of the alpha subunits, thereby driving them into their inactive gdp-bound form. down-regulates g- protein-mediated release of inositol phosphates and activation of map kinases.
22228	
22229	may play a role in apoptosis. may act as a tumor suppressor.
22230	core component of nucleosome. nucleosomes wrap and compact dna into chromatin, limiting dna accessibility to the cellular machineries which require dna as a template. histones thereby play a central role in transcription regulation, dna repair, dna replication and chromosomal stability. dna accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodelling.
22231	implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2a, regulation of mrna trafficking and stability in association with elavl1, and inhibition of acetyltransferases as part of the inhat (inhibitor of histone acetyltransferases) complex.
22232	catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (srebps). other known substrates are bdnf and atf6.
22233	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
22234	
22235	may have potent implications in lung endothelial cell- leukocyte interactions.
22236	
22237	stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
22238	receptor for the tridecapeptide neurotensin. it is associated with g proteins that activate a phosphatidylinositol- calcium second messenger system.
22239	
22240	
22241	specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
22242	
22243	
22244	
22245	
22246	plays a role in the insulin signaling pathway.
22247	
22248	
22249	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
22250	f-actin capping proteins bind in a ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
22251	
22252	low concentration of a soluble form of interleukin-6 receptor acts as an agonist of il6 activity.
22253	component of pre-mrna cleavage complex ii and of the trna splicing endonuclease complex.
22254	probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment.
22255	mediates gpi anchoring in the endoplasmic reticulum, by replacing a protein@#$%&s c-terminal gpi attachment signal peptide with a pre-assembled gpi. during this transamidation reaction, the gpi transamidase forms a carbonyl intermediate with the substrate protein.
22256	
22257	
22258	fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
22259	likely to play an important role in intracellular protein and peptide metabolism.
22260	
22261	transcriptional repressor. mad binds with max to form a sequence-specific dna-binding protein complex which recognizes the core sequence 5@#$%&-cac[ga]tg-3@#$%&. mad thus antagonizes myc transcriptional activity by competing for max.
22262	stimulates the kinase activity of stk38 and stk38l.
22263	
22264	
22265	
22266	
22267	
22268	
22269	probable scaffold protein that may be involved in mrna transport (potential).
22270	
22271	
22272	
22273	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
22274	plays a role in the physiological regulation of the intracellular coa concentration (by similarity).
22275	
22276	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity.
22277	
22278	this is a carcinoma-associated protein, probably a mucin.
22279	
22280	
22281	cell surface proteoglycan that bears heparan sulfate.
22282	interacts with functionally mature hetero-oligomeric progesterone receptor complexes along with hsp90 and tebp.
22283	one of the major pre-mrna-binding proteins. binds tenaciously to poly(c) sequences. likely to play a role in the nuclear metabolism of hnrnas, particularly for pre-mrnas that contain cytidine-rich sequences. can also bind poly(c) single- stranded dna.
22284	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
22285	
22286	may be involved in cell-surface proteolysis, cell adhesion or intracellular protein maturation.
22287	
22288	
22289	
22290	
22291	transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types.
22292	
22293	macrophage-specific membrane transport. important in metal transport, in particular iron.
22294	
22295	
22296	component of the sin3-repressing complex. enhances the ability of sin3-hdac1-mediated transcriptional repression. when tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins.
22297	plays a role in valine and pyrimidine metabolism. binds fatty acyl-coa.
22298	
22299	interacts with the e6 protein of the cancer-associated human papillomavirus types 16 and 18. the e6/e6-ap complex binds to and targets the p53 tumor-suppressor protein for ubiquitin- mediated proteolysis. it is an e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. it can target itself for ubiquitination in vitro and efficiently promotes its own degradation in vivo. it appears that only unmodified e6-ap molecules can bind efficiently to p53 in the presence of the hpv e6 oncoprotein.
22300	catalyzes the first committed step in the biosynthesis of complex n-glycans. it controls conversion of high mannose to complex n-glycans; the final hydrolytic step in the n-glycan maturation pathway.
22301	the soluble form is chemotactic for t-cells and monocytes, but not for neutrophils. the membrane-bound form promotes adhesion of those leukocytes to endothelial cells. may play a role in regulating leukocyte adhesion and migration processes at the endothelium. binds to cx3cr1.
22302	heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
22303	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
22304	
22305	
22306	
22307	
22308	dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. could be involved in a signal transduction pathway necessary for late myogenesis, although its ubiquitous expression suggests a wider function.
22309	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
22310	igf-binding proteins prolong the half-life of the igfs and have been shown to either inhibit or stimulate the growth promoting effects of the igfs on cell culture. they alter the interaction of igfs with their cell surface receptors.
22311	
22312	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
22313	
22314	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
22315	
22316	involved in translocation of long-chain fatty acids (lfca) across the plasma membrane. the lfca import appears to be hormone-regulated in a tissue-specific manner. in adipocytes, but not myocytes, insulin induces a rapid translocation of fatp1 from intracellular compartments to the plasma membrane, paralleled by increased lfca uptake. may act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. plays a pivotal role in regulating available lfca substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. may be involved in regulation of cholesterol metabolism. has acyl-coa ligase activity for long-chain and very-long-chain fatty acids.
22317	may participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. may function as a regulatory subunit of ion channels.
22318	oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
22319	
22320	
22321	
22322	receptor for wnt proteins. most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk- 3 kinase, nuclear accumulation of beta-catenin and activation of wnt target genes. a second signaling pathway involving pkc and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for wnt-mediated inactivation of gsk-3 kinase. both pathways seem to involve interactions with g-proteins. may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
22323	binds to the 5@#$%&stem-loop of u4 snrna and may play a role in the late stage of spliceosome assembly. the protein undergoes a conformational change upon rna-binding.
22324	
22325	
22326	
22327	
22328	not known, could be a tyrosine-phosphatase.
22329	
22330	
22331	
22332	
22333	
22334	
22335	negatively regulates tyrosine hydroxylase activity.
22336	
22337	
22338	
22339	nuclear hormone receptor. the steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
22340	anticoagulant plasma protein; it is a cofactor to activated protein c in the degradation of coagulation factors va and viiia. it helps to prevent coagulation and stimulating fibrinolysis.
22341	
22342	
22343	
22344	
22345	
22346	
22347	
22348	participates in the regulation of gene transcription. binds dna both in a non-specific manner and also specifically to recognizes the core sequence 5@#$%&-cac[ga]tg-3@#$%&. seems to activate the transcription of growth-related genes.
22349	
22350	zinc metalloprotease. exhibits aminopeptidase activity against neurogranin in vitro. does not hydrolyze angiotensin-2.
22351	
22352	
22353	
22354	promotes the exchange of ras-bound gdp by gtp. this protein positively controls the level of cellular camp at start, the stage at which the yeast cell division cycle is triggered.
22355	
22356	
22357	
22358	
22359	probable component of the protein complex eif4f, which is involved in the recognition of the mrna cap, atp-dependent unwinding of 5@#$%&-terminal secondary structure and recruitment of mrna to the ribosome. thought to be a functional homolog of eif4g1.
22360	may have a growth inhibitory role.
22361	
22362	
22363	
22364	
22365	
22366	
22367	
22368	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
22369	
22370	
22371	
22372	
22373	
22374	
22375	
22376	
22377	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2). icam3 is also a ligand for integrin alpha-d/beta-2.
22378	
22379	
22380	
22381	
22382	
22383	might normally function as a repressor. ews-fusion- proteins (efps) may play a role in the tumorigenic process. they may disturb gene expression by mimicking, or interfering with the normal function of ctd-polii within the transcription initiation complex. they may also contribute to an aberrant activation of the fusion protein target genes.
22384	sequence-specific transcriptional activator. recognizes the dna sequence 5@#$%&-c[ca]ggaagt-3@#$%&.
22385	might normally function as a repressor. ews-fusion- proteins (efps) may play a role in the tumorigenic process. they may disturb gene expression by mimicking, or interfering with the normal function of ctd-polii within the transcription initiation complex. they may also contribute to an aberrant activation of the fusion protein target genes.
22386	
22387	
22388	
22389	
22390	
22391	catalyzes the cyclization of (s)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
22392	
22393	collagen type iv is specific for basement membranes.
22394	
22395	
22396	
22397	
22398	
22399	
22400	
22401	
22402	
22403	terminal component of the liver microsomal stearyl-coa desaturase system, that utilizes o(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-coa substrates including palmitoyl-coa and stearoyl-coa.
22404	may be involved in transcriptional regulation.
22405	
22406	band 3 is the major integral glycoprotein of the erythrocyte membrane. band 3 has two functional domains. its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin.
22407	converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an nad-dependent reaction.
22408	
22409	
22410	acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. one of the activated genes is an inhibitor of cyclin-dependent kinases. apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of bcl-2 expression.
22411	
22412	required for the methylation step in diphthamide biosynthesis (by similarity).
22413	may play a role in the control of gene expression.
22414	
22415	
22416	
22417	involved in control of the cell cycle. upon lytic infection of permissive cells, the hsv transactivator protein vp16 associates with hcfc1. binding to hcfc1 activates vp16 for association with the octamer motif-binding protein pou2f1, to form a multiprotein-dna complex responsible for activating transcription of the hsv immediate early genes. also antagonizes transactivation by zbtb17 and gabp2; represses zbtb17 activation of the p15(ink4b) promoter and inhibits its ability to recruit p300. coactivator for egr2 and gabp2. tethers the chromatin modifying set1/ash2 histone h3-k4 methyltrasferase (hmt) and sin3 histone deacetylase (hdac) complexes (involved in the activation and repression of transcription, respectively) together.
22418	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex (by similarity).
22419	produced by macrophages, ifn-alpha have antiviral activities. interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
22420	regulates beta-adrenergic receptor function. beta- arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate g(s) proteins.
22421	
22422	intracellular transport of retinol.
22423	protein phosphatase 1 (pp1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. involved in regulation of ionic conductances and long-term synaptic plasticity. may play an important role in dephosphorylating substrates such as the postsynaptic density-associated ca(2+)/calmodulin dependent protein kinase ii.
22424	implicated in commitment to and/or differentiation of the myocardial lineage. acts as a transcriptional activator of anf in cooperation with gata4.
22425	splice factor that is required for the first atp- dependent step in spliceosome assembly and for the interaction of u2 snrnp with the branchpoint. has weak rna-dependent atpase activity. required for mrna export.
22426	phosphorylates specifically ribosomal protein s6 in response to insulin or several classes of mitogens.
22427	muscle contraction.
22428	may be involved in transcriptional regulation.
22429	transcriptional repressor binding to promoters of vertebrate c-myc gene. also binds to the plk and pim1 promoters. may prevent the access of transcriptional activators to enhancers. also acts as a transcriptional activator of app. involved in different aspects of gene regulation including promoter activation or repression, hormone-responsive gene silencing, methylation- dependent chromatin insulation, and genomic imprinting. seems to act as tumor suppressor.
22430	egf stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture.
22431	
22432	
22433	
22434	may be responsible for potassium buffering action of glial cells in the brain. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. can be blocked by extracellular barium and cesium (by similarity).
22435	
22436	resistance to tetracycline by an active tetracycline efflux. this is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. this protein functions as a metal-tetracycline/h(+) antiporter.
22437	this protein mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
22438	lysosomal serine protease with tripeptidyl-peptidase i activity. may act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. requires substrates with an unsubstituted n-terminus (by similarity).
22439	ph-dependent, voltage-insensitive, background potassium channel protein. rectification direction results from potassium ion concentration on either side of the membrane. acts as an outward rectifier when external potassium concentration is low. when external potassium concentration is high, current is inward.
22440	regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. confers calcium sensitivity.
22441	collagen type iv is specific for basement membranes.
22442	transfers sialic acid from the donor of substrate cmp- sialic acid to galactose containing acceptor substrates.
22443	
22444	
22445	syntaxin that may be involved in targeting and fusion of golgi-derived retrograde transport vesicles with the er.
22446	
22447	cellular negative regulator of the hepatitis b virus (hbv) x protein.
22448	
22449	
22450	
22451	signal-recognition-particle assembly, binds directly to 7s rna and mediates binding of the 54 kda subunit of the srp.
22452	h2afx is a basal histone. histones are basic nuclear proteins that are required to maintain the nucleosome structure of the chromosomal fiber in eukaryotes. required for checkpoint- mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of dna double strand breaks (dsbs) specifically when modified by c-terminal phosphorylation.
22453	
22454	
22455	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1@#$%&-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. the enzyme also hydroxylates etoposide.
22456	
22457	
22458	cleaves the c-terminal propeptides of procollagen i, ii and iii. induces cartilage and bone formation.
22459	
22460	
22461	
22462	
22463	one of the major pre-mrna-binding proteins. binds tenaciously to poly(c) sequences. likely to play a role in the nuclear metabolism of hnrnas, particularly for pre-mrnas that contain cytidine-rich sequences. can also bind poly(c) single- stranded dna.
22464	
22465	
22466	muscle contraction.
22467	
22468	
22469	helicase; has atpase activity.
22470	
22471	plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
22472	
22473	involved in regulating eumelanin and phaeomelanin levels.
22474	
22475	the soluble form is chemotactic for t-cells and monocytes, but not for neutrophils. the membrane-bound form promotes adhesion of those leukocytes to endothelial cells. may play a role in regulating leukocyte adhesion and migration processes at the endothelium. binds to cx3cr1.
22476	
22477	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
22478	
22479	transcriptional activator that binds to the sterol regulatory element 1 (sre-1) (5@#$%&-atcaccccac-3@#$%&). has dual sequence specificity, binding to both an e-box motif (5@#$%&-atcacgtga-3@#$%&) and to sre-1 (5@#$%&-atcaccccac-3@#$%&). regulates the transcription of genes for sterol biosynthesis and the ldl receptor gene.
22480	
22481	
22482	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
22483	collagen type iii occurs in most soft connective tissues along with type i collagen.
22484	
22485	
22486	regulatory factor essential for mhc class ii genes expression. binds to the x boxes of mhc class ii genes. also binds to an inverted repeat (enh1) required for hepatitis b virus genes expression and to the most upstream element (alpha) of the rpl30 promoter.
22487	
22488	
22489	may facilitate pttg1 nuclear translocation.
22490	
22491	essential for cell viability. taf9 and taf9l are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. may have a role in gene regulation associated with apoptosis. tafs are components of the transcription factor iid (tfiid) complex, the tbp-free tafii complex (tftc), the pcaf histone acetylase complex and the staga transcription coactivator-hat complex. tfiid or tftc are essential for the regulation of rna polymerase ii-mediated transcription (by similarity).
22492	may be involved in cell growth. probably acts as a terminal oxidase of plasma electron transport from cytosolic nad(p)h via hydroquinones to acceptors at the cell surface. hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. the activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
22493	
22494	exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper b into subunit i (by similarity).
22495	the heterodimer with hif1a or epas1/hif2a functions as a transcriptional regulator of the adaptive response to hypoxia.
22496	may participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.
22497	vital for proper neuronal development and hatching.
22498	
22499	
22500	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
22501	
22502	
22503	
22504	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
22505	
22506	
22507	receptor for extracellular adenine nucleotides such as atp and adp. in pancreatic islets, may mediate some of the effects of extracellular atp on insulin secretion.
22508	
22509	
22510	
22511	
22512	
22513	
22514	
22515	
22516	
22517	
22518	
22519	
22520	stimulates specifically the gtpase activity of ypt6.
22521	
22522	
22523	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
22524	
22525	
22526	possibly acts as a transcriptional regulatory factor.
22527	
22528	
22529	
22530	
22531	
22532	
22533	
22534	
22535	
22536	
22537	
22538	
22539	
22540	
22541	
22542	
22543	
22544	
22545	
22546	
22547	
22548	
22549	
22550	
22551	
22552	
22553	
22554	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial @#$%!stem cells@#$%!.
22555	
22556	
22557	
22558	
22559	
22560	
22561	
22562	
22563	
22564	acts as a microtubule-associated protein which interacts with cytoplasmic microtubules through beta-tubulin.
22565	
22566	polycomb group (pcg) protein. pcg proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. participates to the etv6-mediated repression. probably plays a role in cell proliferation. overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
22567	complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. may form part of a tissue- specific acute response to remodeling stimuli. known to act on mmp-1, mmp-2, mmp-3, mmp-7, mmp-9, mmp-13, mmp-14 and mmp-15.
22568	calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.
22569	
22570	transcription factor which binds specifically to the mef2 element present in the regulatory regions of many muscle- specific genes. activates transcription via this element. may be involved in muscle-specific and/or growth factor-related transcription.
22571	
22572	
22573	may function as a transcription factor. seems to repress transcription.
22574	catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (by similarity).
22575	
22576	plays a role in pre-mrna alternative splicing by regulating spliceosome assembly.
22577	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems. the g(o) protein function is not clear.
22578	this protein is a minor sialoglycoprotein in erythrocyte membranes.
22579	interconverts glcnac-6-p and glcnac-1-p.
22580	
22581	acts as an adapter protein of the fyn and sh2-domain- containing leukocyte protein-76 (slp76) signaling cascades in t cells. modulates the expression of interleukin-2 (il-2).
22582	
22583	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
22584	
22585	
22586	central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. together with tom22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the tom40 translocation pore (by similarity).
22587	required for the first step of diphtamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from s-adenosyl-l- methionine to a histidine residue. diphthamide is a post- translational modification of histidine which occurs in elongation factor 2.
22588	
22589	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
22590	
22591	
22592	
22593	
22594	
22595	
22596	catalyzes the removal of sialic acid (n-acetylneuramic acid) moities from glycoproteins and glycolipids. to be active, it is strictly dependent on its presence in the multienzyme complex. appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
22597	
22598	component of the origin recognition complex (orc) that binds origins of replication. it has a role in both chromosomal replication and mating type transcriptional silencing. binds to the ars consensus sequence (acs) of origins of replication in an atp-dependent manner.
22599	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
22600	
22601	
22602	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the complex p170-eif3.
22603	
22604	component of the exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature nuclear complex. also associated with the gtpase ran. has a 3@#$%&-5@#$%& exonuclease activity.
22605	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
22606	may play a role in promoting maturation and morphological differentiation of cerebellar neurons.
22607	
22608	
22609	may play a role in host defense against tumors and pathogens. binds z-dna (by similarity).
22610	converts inositol hexakisphosphate (insp6) to diphosphoinositol pentakisphosphate (insp7/pp-insp5). converts 1,3,4,5,6-pentakisphosphate (insp5) to pp-insp4.
22611	may have a specific function in the mechanism or regulation of t-cell cytolytic activity.
22612	regulatory subunit of glucosidase ii.
22613	implicated in tumor cell metastasis. may function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction.
22614	
22615	converts big endothelin-1 to endothelin-1.
22616	
22617	
22618	
22619	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb.
22620	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. active on 1- chloro-2,4-dinitrobenzene.
22621	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. active on 1- chloro-2,4-dinitrobenzene.
22622	
22623	
22624	interacts with mapk kinases and regulates activation of map kinases. does not display kinase activity (by similarity).
22625	involved in cell wall synthesis where it is required for glycosylation. involved in cell cycle progression through cell- size checkpoint.
22626	
22627	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
22628	binds to actin and affects the structure of the cytoskeleton. at high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. by binding to pip2, it inhibits the formation of ip3 and dg.
22629	catalytic subunit of the peripheral v1 complex of vacuolar atpase. v-atpase vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
22630	transfers sialic acid from the donor of substrate cmp- sialic acid to galactose containing acceptor substrates.
22631	
22632	associates with cyclin g and cdk5. seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by hsc70 in non-neuronal cells. expression oscillates slightly during the cell cycle, peaking at g1.
22633	
22634	
22635	
22636	catalyzes the conjugation of leukotriene a4 with reduced glutathione to form leukotriene c4.
22637	involved with pre-mrna processing. forms complexes (ribonucleosomes) with at least 20 other different hnrnp and heterogeneous nuclear rna in the nucleous.
22638	signal-transducing molecule. may have a common pathway with il6st. the soluble form inhibits the biological activity of lif by blocking its binding to receptors on target cells.
22639	amine transporter. terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
22640	branching enzyme that converts linear into branched poly-n-acetyllactosaminoglycans. introduces the blood group i antigen during embryonic development. it is closely associated with the development and maturation of erythroid cells.
22641	catalyzes the s-methylation of thiopurine drugs such as 6-mercaptopurine.
22642	
22643	tubulin-folding protein; involved in the final step of the tubulin folding pathway.
22644	mediates estrogen action in various target organs.
22645	inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. receptor for beta-endorphin.
22646	may function as part of a signaling pathway that acts to regulate the size of the body fat depot. an increase in the level of lep may act directly or indirectly on the cns to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
22647	
22648	thiol protease which is believed to participate in intracellular degradation and turnover of proteins. has also been implicated in tumor invasion and metastasis.
22649	
22650	
22651	
22652	
22653	acts as a gtpase activating protein for rab5a. involved in receptor trafficking. in complex with eps8 inhibits internalization of egfr.
22654	binds to actin and plays an important role in the assembly of the z-disk.
22655	
22656	actin cross-linking/gelling protein (by similarity). involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
22657	secretory vesicle-specific electron transport protein.
22658	single stranded dna-dependent atp-dependent helicase. has a role in chromosome translocation. the dna helicase ii complex binds preferentially to fork-like ends of double-stranded dna in a cell cycle-dependent manner. it works in the 3@#$%&-5@#$%& direction. binding to dna may be mediated by p70. involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination. the ku p70/p86 dimer acts as regulatory subunit of the dna-dependent protein kinase complex dna-pk by increasing the affinity of the catalytic subunit prkdc to dna by 100-fold. the ku p70/p86 dimer is probably involved in stabilizing broken dna ends and bringing them together. the assembly of the dna-pk complex to dna ends is required for the nhej ligation step. required for osteocalcin gene expression (by similarity).
22659	the insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.
22660	excises uracil residues from the dna which can arise as a result of misincorporation of dump residues by dna polymerase or due to deamination of cytosine.
22661	
22662	
22663	
22664	
22665	catalyzes the hydrolysis of gtp bound to the 40s ribosomal initiation complex (40s.mrna.met-trna[f].eif-2.gtp) with the subsequent joining of a 60s ribosomal subunit resulting in the release of eif-2 and the guanine nucleotide. the subsequent joining of a 60s ribosomal subunit results in the formation of a functional 80s initiation complex (80s.mrna.met-trna[f]).
22666	component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. the nua4 complex atpase and helicase activities seem to be, at least in part, contributed by the association of ruvbl1 and ruvbl2 with ep400. nua4 may also play a direct role in dna repair when directly recruited to sites of dna damage. also component of the msin3a complex which acts to repress transcription by deacetylation of nucleosomal histones.
22667	may be involved in transcriptional regulation.
22668	
22669	overproduction suppresses the slow growth phenotype of cpr7 mutant cells.
22670	potential central metabolic regulator.
22671	
22672	
22673	haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes.
22674	rab effector protein acting as linker between gamma- adaptin, rab4a and rab5a. involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. stimulates rabgef1 mediated nucleotide exchange on rab5a.
22675	may be involved in transcriptional regulation.
22676	
22677	inter-alpha-trypsin inhibitor, present in plasma and urine, inhibits trypsin, plasmin, and lysosomal granulocytic elastase (by similarity).
22678	may act as a calcium-sensitive regulator of exocytosis in exocrine tissues. it binds to syntaxin at low calcium concentrations and dissociates at concentrations known to stimulate exocytosis.
22679	
22680	
22681	collagen type iv is specific for basement membranes.
22682	has a tumor-suppressor role for nes1 in breast and prostate cancer.
22683	may function as a cell-type specific modulator for g protein-mediated cell signaling.
22684	cochaperone that binds directly to hsc70 and hsp70 and regulates their atpase activity.
22685	functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. upon ligand activation through the released notch intracellular domain (nicd) it forms a transcriptional activator complex with rbp-j kappa and activates genes of the enhancer of split locus. affects the implementation of differentiation, proliferation and apoptotic programs (by similarity). may play a role during cns development.
22686	the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the er, via the golgi up to the trans golgi network. coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-er transport of dilysine-tagged proteins. in mammals, the coatomer can only be recruited by membranes associated to adp-ribosylation factors (arfs), which are small gtp-binding proteins; the complex also influences the golgi structural integrity, as well as the processing, activity, and endocytic recycling of ldl receptors (by similarity).
22687	phosphorylates a large number of substrates in the cytoplasm and the nucleus.
22688	
22689	may act in the sexual differentiation pathway (by similarity).
22690	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. isoform alpha-1i gives rise to t-type calcium currents. t-type calcium channels belong to the @#$%!low-voltage activated (lva)@#$%! group and are strongly blocked by nickel and mibefradil. a particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. t-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. they may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. gates in voltage ranges similar to, but higher than alpha 1g or alpha 1h (by similarity).
22691	
22692	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of calcium.
22693	adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. preferentially binds to alpha2,3- linked sialic acid (by similarity).
22694	
22695	
22696	
22697	catalyzes the removal of elemental sulfur from cysteine to produce alanine. it supplies the inorganic sulfur for iron- sulfur (fe-s) clusters.
22698	
22699	may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
22700	
22701	
22702	
22703	
22704	
22705	
22706	
22707	type i collagen is a member of group i collagen (fibrillar forming collagen).
22708	
22709	
22710	this protein is a component of ribonucleosomes. could be needed to organize a concentration gradient of a dorsalizing morphogen (dm) originating in the germinal vesicle. at least one of the isoforms is essential in somatic tissues.
22711	
22712	
22713	
22714	
22715	
22716	
22717	
22718	
22719	
22720	
22721	implicated in the suppression of cell death. interacts with the bcl-2 and adenovirus e1b 19 kda proteins (by similarity).
22722	
22723	
22724	
22725	
22726	
22727	
22728	
22729	
22730	
22731	
22732	
22733	
22734	muscle contraction.
22735	
22736	
22737	
22738	
22739	
22740	
22741	
22742	may be involved in the regulation of gene expression by covalent modification of histone proteins. the long isoform is a corepressor of estrogen receptor (er). the short isoform binds to er and sequesters it in the cytoplasm and enhances non-genomic responses of er.
22743	major glycoprotein of vascular endothelium. may play a critical role in the binding of endothelial cells to integrins and/or other rgd receptors.
22744	
22745	
22746	
22747	
22748	
22749	subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-golgi network (tgn) to the endosomal-lysosomal system.
22750	
22751	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. participates in pre-mrna splicing. may play a role in the assembly of the u4/u5/u6 tri-snrnp complex. may act as a chaperone.
22752	
22753	
22754	
22755	
22756	muscle contraction.
22757	
22758	this oncogene is expressed in neonatal brain. fgf-5 can transform nih 3t3 cells.
22759	
22760	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
22761	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
22762	
22763	
22764	required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.
22765	the classic group of mbp isoforms (isoform 4-isoform 14) are with plp the most abundant protein components of the myelin membrane in the cns. they have a role in both its formation and stabilization. the smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. the non- classic group of mbp isoforms (isoform 1-isoform 3/golli-mbps) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in t- cells and neural cells. differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.
22766	
22767	
22768	
22769	
22770	associated with the mammalian reproductive process. catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
22771	collagen type iii occurs in most soft connective tissues along with type i collagen.
22772	
22773	
22774	3@#$%&-exoribonuclease that has a preference for poly(a) tails of mrnas, thereby efficiently degrading poly(a) tails. exonucleolytic degradation of the poly(a) tail is often the first step in the decay of eukaryotic mrnas and is also used to silence certain maternal mrnas translationally during oocyte maturation and early embryonic development. interacts with both the 3@#$%&-end poly(a) tail and the 5@#$%&-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(a) tails. involved in nonsense-mediated mrna decay, a critical process of selective degradation of mrnas that contain premature stop codons. also involved in degradation of inherently unstable mrnas that contain au-rich elements (ares) in their 3@#$%& untranslated regions, possibly via its interaction with khsrp. probably mediates the removal of poly(a) tails of ares mrnas, which constitutes the first step of destabilization.
22775	
22776	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
22777	
22778	
22779	
22780	
22781	sodium-dependent amino acid/proton antiporter. mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. also recognizes histidine, asparagine and alanine. may mediate amino acid transport in either direction under physiological conditions. may play a role in nitrogen metabolism and synaptic transmission.
22782	calcium channel protein which plays an important role in excitation-contraction coupling.
22783	may be involved in transcriptional regulation as a repressor. candidate gene for wolf-hirschhorn (4p-) syndrome (whs).
22784	voltage-gated chloride channel. chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase c. it could help neuronal cells to establish short- term memory.
22785	histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). in addition, histatins exhibit antibacterial and antifungal activities.
22786	
22787	
22788	has a role in pre-mrna splicing. phosphorylates sf2/asf.
22789	
22790	
22791	
22792	
22793	
22794	
22795	potential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes.
22796	
22797	
22798	
22799	
22800	
22801	rna-binding protein. associated to polysomes and might be involved in the transport of mrna from the nucleus to the cytoplasm.
22802	exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper b into subunit i (by similarity).
22803	
22804	
22805	
22806	may constitute a novel regulatory system for basal transcription. negatively regulates abt1 (by similarity).
22807	
22808	
22809	
22810	
22811	
22812	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell.
22813	
22814	this protein is a component of ribonucleosomes. could be needed to organize a concentration gradient of a dorsalizing morphogen (dm) originating in the germinal vesicle. at least one of the isoforms is essential in somatic tissues.
22815	
22816	
22817	
22818	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the transport of calcium out of the cell.
22819	protein phosphatase (pp1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. involved in regulation of ionic conductances and long-term synaptic plasticity.
22820	cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. also permeable for ca(2+), li(+) and k(+). generates a biphasic current with a fast inactivating and a slow sustained phase. mediates glutamate-independent ca(2+) entry into neurons upon acidosis. this ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. heteromeric channel assembly seems to modulate channel properties.
22821	
22822	rna-binding protein. possesses nucleolytic activity against cytotoxic lymphocyte target cells. may be involved in apoptosis.
22823	
22824	
22825	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
22826	receptor for steroids (potential).
22827	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
22828	actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (by similarity).
22829	
22830	transports cmp-sialic acid from the cytosol into golgi vesicles where glycosyltransferases function.
22831	
22832	responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. plays a role in the regulation of protein translation by phosphorylating and inactivating eef2k.
22833	
22834	cytokine that inhibits the activity of bmp2 and bmp4 in a dose-dependent manner. antagonized bmp4-induced suppression of progesterone production in granulosa cells (by similarity).
22835	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
22836	
22837	mediates estrogen action in various target organs.
22838	has no ubiquitin ligase activity on its own. the ube2v2/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through lys-62. this type of poly-ubiquitination does not lead to protein degradation by the proteasome. mediates transcriptional activation of target genes. plays a role in the control of progress through the cell cycle and differentiation. plays a role in the error-free dna repair pathway and contributes to the survival of cells after dna damage.
22839	
22840	
22841	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
22842	involved in dna excision repair. may play a part in dna damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes.
22843	catalyzes the posttranslational formation of 4- hydroxyproline in -xaa-pro-gly- sequences in collagens and other proteins.
22844	
22845	
22846	not known, could be a tyrosine-phosphatase.
22847	receptor-proximal protein kinase regulating integrin- mediated signal transduction. may act as a mediator of inside-out integrin signaling. focal adhesion protein part of the complex ilk-pinch. this complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also akt1 and gsk3b.
22848	
22849	
22850	involved in repair of uv radiation-induced dna damage. catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same dna strand upon exposure to ultraviolet radiation.
22851	
22852	
22853	this is a receptor for the anterior pituitary hormone prolactin.
22854	
22855	
22856	
22857	one of the major glycoproteins of thymocytes and t lymphocytes. plays a role in the physicochemical properties of the t-cell surface and in lectin binding. presents carbohydrate ligands to selectins. has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. is a counter receptor for sn/siglec-1 (by similarity). during t-cell activation is actively removed from the t-cell-apc (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (by similarity).
22858	
22859	
22860	
22861	
22862	
22863	functions as a component of the nuclear pore complex (npc). npc components, collectively referred to as nucleoporins (nups), can play the role of both npc structural components and of docking or interaction partners for transiently associated nuclear transport factors. involved in nuclear poly(a)+ rna export and npc biogenesis, it is also required for normal nuclear morphology.
22864	
22865	binds specifically to phosphatidylinositol-3-phosphate (ptdins3p), but not to other phosphoinositides.
22866	methylates cpg residues. preferentially methylates hemimethylated dna. it is responsible for maintaining methylation patterns established in development. mediates transcriptional repression by direct binding to hdac2.
22867	phosphorylates a large number of substrates in the cytoplasm and the nucleus.
22868	involved in the homologous recombination repair (hrr) pathway of double-stranded dna breaks arising during dna replication or induced by dna-damaging agents. the bcdx2 complex binds single-stranded dna, single-stranded gaps in duplex dna and specifically to nicks in duplex dna.
22869	binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate.
22870	
22871	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
22872	
22873	
22874	required for protein transport from the endoplasmic reticulum to the golgi complex (by similarity).
22875	involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. activates rac1 and rac2 small gtpases, probably by functioning as a guanine nucleotide exchange factor (gef), which exchanges bound gdp for free gtp. may also participate in il2 transcriptional activation via the activation of rac2.
22876	
22877	could regulate proteolytic events associated with testicular germ cell maturation.
22878	catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of nad. it is the rate limiting component in the mammalian nad biosynthesis pathway (by similarity).
22879	
22880	
22881	part of the dynein complex of respiratory cilia.
22882	
22883	type i collagen is a member of group i collagen (fibrillar forming collagen).
22884	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
22885	
22886	
22887	
22888	
22889	
22890	
22891	binds to isre-like element (interferon-stimulated response element) of myc p2 promoter.
22892	
22893	
22894	aminopeptidase with broad substrate specificity to several peptides. involved in proteolytic events essential for cell growth and viability. may act as regulator of neuropeptide activity (by similarity).
22895	
22896	
22897	
22898	
22899	
22900	
22901	
22902	may be involved in transcriptional regulation.
22903	
22904	
22905	
22906	
22907	
22908	
22909	
22910	the jnk-interacting protein (jip) group of scaffold proteins selectively mediates jnk signaling by aggregating specific components of the mapk cascade to form a functional jnk signaling module. required for jnk activation in response to excitotoxic stress. cytoplasmic mapk8ip1 causes inhibition of jnk- regulated activity by retaining jnk in the cytoplasm and inhibiting jnk phosphorylation of c-jun. may also participate in apoer2-specific reelin signaling. directly, or indirectly, regulates glut2 gene expression and beta-cell function. appears to have a role in cell signaling in mature and developing nerve terminals. may function as a regulator of vesicle transport, through interactions with the jnk-signaling components and motor proteins (by similarity). functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.
22911	
22912	
22913	may be involved in transcriptional regulation.
22914	
22915	
22916	
22917	
22918	
22919	
22920	
22921	
22922	
22923	
22924	
22925	binds to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation. inhibits the phosphorylation of nucleosomal histones h3 and h2a by rps6ka5/msk1 and rps6ka3/rsk2 (by similarity).
22926	
22927	
22928	
22929	
22930	
22931	
22932	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
22933	
22934	
22935	
22936	
22937	
22938	
22939	
22940	collagen type iv is specific for basement membranes.
22941	
22942	
22943	
22944	
22945	
22946	
22947	
22948	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
22949	
22950	
22951	
22952	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes.
22953	could regulate beta-glucan synthesis. overexpression provides resistance to hm-1 killer toxin.
22954	
22955	transcriptional factor which uses the canonical single or multiple carg boxes dna sequence. acts as a cofactor of serum response factor (srf) and has the potential to modulate srf-target genes. suppresses tnf-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. it may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (by similarity).
22956	electroneutral exchange of protons for na(+) and k(+) across the mitochondrial inner membrane. contributes to organellar volume and calcium homeostasis.
22957	may act as a specific coactivator for the mammalian tefs (by similarity).
22958	
22959	
22960	involved in pyrimidine base degradation. catalyzes the reduction of uracil and thymine. also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
22961	
22962	
22963	
22964	tyrosine kinase of the non-receptor type, involved in the ifn-alpha/beta/gamma signal pathway. kinase partner for the interleukin (il)-2 receptor.
22965	
22966	
22967	
22968	
22969	could regulate beta-glucan synthesis. overexpression provides resistance to hm-1 killer toxin.
22970	promotes the exchange of gdp by gtp (by similarity).
22971	may function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins.
22972	probably involved in the repair of mismatches in dna.
22973	
22974	
22975	blocks ras-mediated inhibition of integrin activation and modulates the erk map kinase cascade. inhibits rps6ka3 activities by retaining it in the cytoplasm (by similarity). inhibits both tnfrsf6- and tnfrsf1a-mediated casp8 activity and apoptosis. regulates glucose transport by controlling both the content of slc2a1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of slc2a4 from the cell interior to the surface.
22976	
22977	functions as a myeloid and b-cell proto-oncogene. may play important roles in leukemogenesis and hematopoiesis. an essential factor in lymphopoiesis, is required for b-cell formation in fetal liver. may function as a modulator of the transcriptional repression activity of arp1 (by similarity).
22978	
22979	
22980	receptor for neuropeptide y and peptide yy. the rank order of affinity of this receptor for pancreatic polypeptides is npy = pyy >= npy (2-36) = [leu-31, pro-34] npy > npy (13-36) > pp. the activity of this receptor is mediated by g proteins that inhibits adenylate cyclase activity.
22981	
22982	
22983	
22984	
22985	
22986	
22987	mediates ubiquitination of cellular proteins.
22988	may play a role in fertility and microtubule formation through interaction with ranbp9.
22989	
22990	chemoattractant active on t-lymphocytes, monocytes, but not neutrophils. sdf-1-beta(3-72) and sdf-1-alpha(3-67) show a reduced chemotactic activity. binding to cell surface proteoglycans seems to inhibit formation of sdf-1-alpha(3-67) and thus to preserve activity on local sites.
22991	
22992	
22993	
22994	
22995	
22996	serine protease. hydrolyzes the peptides n-t-boc-gln- ala-arg-amc and n-t-boc-gln-gly-arg-amc and, to a lesser extent, n-t-boc-ala-phe-lys-amc and n-t-boc-val-leu-lys-amc. has a preference for substrates with an arg instead of a lys residue in position p1.
22997	plays a role in the formation of functional neural circuits from the early stages of synapse formation. has a role in the development of cns functions involved in locomotor activity.
22998	
22999	
23000	type i collagen is a member of group i collagen (fibrillar forming collagen).
23001	
23002	
23003	
23004	
23005	
23006	dna- and rna binding protein, involved in several nuclear processes. binds the conventional octamer sequence in double stranded dna. also binds single-stranded dna and rna at a site independent of the duplex site (by similarity). involved in pre-mrna splicing, probably as an heterodimer with sfpq. interacts with u5 snrna, probably by binding to a purine-rich sequence located on the 3@#$%& side of u5 snrna stem 1b. the sfpq-nono heteromer associated with matr3 may play a role in nuclear retention of defective rnas. the sfpq-nono heteromer may be involved in dna unwinding by modulating the function of topoisomerase i/top1. the sfpq-nono heteromer may be involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination and may stabilize paired dna ends. in vitro, the complex strongly stimulates dna end joining, binds directly to the dna substrates and cooperates with the ku70/g22p1-ku80/xrcc5 (ku) dimer to establish a functional preligation complex. nono is involved in transcriptional regulation. the sfpq-nono-nr5a1/sf-1 complex binds to the cyp17 promoter and regulates basal and camp-dependent transcriptional avtivity. nono binds to an enhancer element in long terminal repeats of endogenous intracisternal a particles (iaps) and activates transcription (by similarity).
23007	participates in the apoptotic response to dna damage. when overproduced, activates transcription from p53-responsive promoters and induces apoptosis. may be a tumor suppressor protein.
23008	
23009	synthesis and degradation of fructose 2,6-bisphosphate.
23010	type i collagen is a member of group i collagen (fibrillar forming collagen).
23011	
23012	
23013	
23014	could act as a core histone necessary for the assembly of centromeres. may replace one or both copies of histone h3 in a certain set of centromeric nucleosomes.
23015	gtpase-activating protein for the adp ribosylation factor family (probable). binds phosphatidylinositol 3,4,5- trisphosphate (ptdinsp3) and inositol 1,3,4,5-tetrakisphosphate (insp4).
23016	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
23017	
23018	may be involved in regulating membrane traffic to and from trans-golgi network.
23019	cleaves the distal alpha 1,2-linked glucose residue from the glc(3)man(9)glcnac(2) oligosaccharide precursor in a highly specific manner.
23020	component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. has a role in the correct positioning of the septum. required for anchoring mad2l1 to the nuclear periphery.
23021	
23022	dna repair enzyme that incises dna at 8-oxog residues. excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-n- methylformamidopyrimidine (fapy) from damaged dna. has a beta- lyase activity that nicks dna 3@#$%& to the lesion.
23023	
23024	crystallins are the dominant structural components of the vertebrate eye lens.
23025	
23026	adds the first dol-p-man derived mannose in an alpha 1,3 linkage to man5glcnac2-pp-dol.
23027	
23028	
23029	calcium-dependent, calmodulin-stimulated protein phosphatase. this subunit may have a role in the calmodulin activation of calcineurin. dephosphorylates hspb1 and ssh1.
23030	
23031	plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. exerts it highest activity toward 3-hydroxybutyryl-coa.
23032	
23033	
23034	
23035	
23036	
23037	may play a role during cellular proliferation and c-myc- mediated transformation (by similarity).
23038	associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mrna splicing.
23039	phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
23040	
23041	
23042	
23043	
23044	probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. may act as a tumor suppressor.
23045	regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. confers calcium sensitivity.
23046	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
23047	
23048	receptor for brain-derived neurotrophic factor (bdnf), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (ngf). involved in the development and/or maintenance of the nervous system. this is a tyrosine-protein kinase receptor. known substrates for the trk receptors are shc1, pi-3 kinase, and plc- gamma-1.
23049	negatively regulates matrix metalloproteinase-9 (mmp-9) by suppressing mmp-9 secretion and by direct inhibition of its enzymatic activity. reck down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. appears to also regulate mmp-2 and mt1-mmp, which are involved in cancer progression.
23050	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
23051	
23052	
23053	component of multiple cytoplasmic organelles. apparently crucial for their normal development and function. may be involved in intracellular protein sorting.
23054	
23055	
23056	
23057	the muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of g proteins. primary transducing effect is pi turnover.
23058	
23059	
23060	replaces conventional h2a in a subset of nucleosomes. may be involved in the formation of constitutive heterochromatin. may be required for chromosome segregation during cell division.
23061	efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an atp-dependent reaction. involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination. the lig4-xrcc4 complex is responsible for the nhej ligation step, and xrcc4 enhances the joining activity of lig4. binding of the lig4-xrcc4 complex to dna ends is dependent on the assembly of the dna- dependent protein kinase complex dna-pk to these dna ends.
23062	efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an atp-dependent reaction. involved in dna nonhomologous end joining (nhej) required for double-strand break repair and v(d)j recombination. the lig4-xrcc4 complex is responsible for the nhej ligation step, and xrcc4 enhances the joining activity of lig4. binding of the lig4-xrcc4 complex to dna ends is dependent on the assembly of the dna- dependent protein kinase complex dna-pk to these dna ends.
23063	
23064	
23065	catalyzes the hydrolysis of gtp bound to the 40s ribosomal initiation complex (40s.mrna.met-trna[f].eif-2.gtp) with the subsequent joining of a 60s ribosomal subunit resulting in the release of eif-2 and the guanine nucleotide. the subsequent joining of a 60s ribosomal subunit results in the formation of a functional 80s initiation complex (80s.mrna.met-trna[f]).
23066	
23067	
23068	
23069	
23070	
23071	
23072	may have a function in cell cycle regulation. binds to and may be involved in the transforming capacity of the adenovirus e1a protein. may act as a tumor suppressor. potent inhibitor of e2f-mediated trans-activation, associates preferentially with e2f5. binds to cyclins a and e.
23073	this is a membrane-bound, calcium-inhibitable adenylyl cyclase.
23074	clathrin is the major protein of the polyhedral coat of coated pits and vesicles. two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-golgi network.
23075	
23076	
23077	binds to nfat-like motifs (purine-rich) in the hiv-1 long terminal repeat and in the il-2 promoter. may be involved in both positive and negative regulation of important viral and cellular promoter elements.
23078	transcriptional activator that binds to the enhancer of the adenovirus e1a gene; the core-binding sequence is 5@#$%&[ac]gga[at]gt-3@#$%&.
23079	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
23080	required for protein import into peroxisomes.
23081	catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in map kinase p38 exclusively.
23082	
23083	
23084	suggested to be involved in kindling epileptogenesis and hippocampal plasticity. has a strong proteolytic activity against fibronectin (by similarity).
23085	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2). icam3 is also a ligand for integrin alpha-d/beta-2.
23086	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2). icam3 is also a ligand for integrin alpha-d/beta-2.
23087	acts as dominant repressor towards other family members. inhibits nf-kappa-b-regulated gene expression. may be required for the initiation and maintenance of the differentiated state.
23088	
23089	
23090	involved in protein-protein interactions at adherens junctions.
23091	
23092	
23093	receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-coa oxidase and activates its transcription. it therefore controls the peroxisomal beta-oxidation pathway of fatty acids.
23094	may play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. seems to demarcate the juxtaparanodal region of the axo-glial junction.
23095	
23096	
23097	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
23098	
23099	
23100	
23101	
23102	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
23103	
23104	
23105	
23106	rna-binding protein. possesses nucleolytic activity against cytotoxic lymphocyte target cells. may be involved in apoptosis.
23107	
23108	terminal component of the liver microsomal stearyl-coa desaturase system, that utilizes o(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-coa substrates including palmitoyl-coa and stearoyl-coa.
23109	
23110	
23111	transcriptional repressor. mxi1 binds with max to form a sequence-specific dna-binding protein complex which recognizes the core sequence 5@#$%&-cac[ga]tg-3@#$%&. mxi1 thus antagonizes myc transcriptional activity by competing for max.
23112	
23113	
23114	essential component of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. when overexpressed in cells induces the formation of cytoplasmic annulate lamellae (al) (by similarity).
23115	
23116	
23117	
23118	
23119	gtpase-activating protein (gap) for arf1 and arf5, which also shows strong gtpase activity. isoform 1 participates to the prevention of neuronal apoptosis by enhancing pi3 kinase activity. it aids the coupling of metabotropic glutamate receptor 1 (grm1) to cytoplasmic pi3 kinase by interacting with homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of ngf by activating nuclear pi3 kinase. isoform 2 does not stimulate pi3 kinase but may protect cells from apoptosis by stimulating akt. it also regulates the adapter protein 1 (ap-1)-dependent trafficking of proteins in the endosomal system.
23120	
23121	type i collagen is a member of group i collagen (fibrillar forming collagen).
23122	
23123	
23124	
23125	
23126	involved in the presentation of foreign antigens to the immune system.
23127	
23128	
23129	capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.
23130	
23131	
23132	
23133	
23134	
23135	
23136	this protein is associated with sn-rnp u2. it helps the a@#$%& protein to bind stem loop iv of u2 snrna (by similarity).
23137	
23138	
23139	
23140	
23141	component of the bactericidal ra-reactive factor rarf which specifically binds to ra and r2 polysaccharides expressed by certain enterobacteria. it triggers the activation of complement cascade by activating the c4 and c2 components. it activates the c4 component by cleaving the alpha-chain of c4.
23142	
23143	
23144	
23145	
23146	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules (by similarity).
23147	
23148	
23149	
23150	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. receptor for bmp-2 and bmp-4.
23151	
23152	vinexin alpha isoform promotes up-regulation of actin stress fiber formation. vinexin beta isoform plays a role in cell spreading and enhances the activation of jnk/sapk in response to egf stimulation by using its third sh3 domain.
23153	
23154	
23155	
23156	not essential for b12 transport; however, it is an auxiliary component of the transport system.
23157	transcriptional repressor.
23158	
23159	
23160	
23161	promotes the exchange of ras-bound gdp by gtp.
23162	ca(2+)-regulated actin-binding protein.
23163	
23164	transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. binds dna on the 5@#$%&-ccac[ga]-3@#$%&half of the er stress response element (erse) (5@#$%&-ccaat-n(9)-ccac[ga]-3@#$%&) and of erse ii (5@#$%&-attgg-n-ccacg-3@#$%&). binding to erse requires binding of nf-y to erse. could also be involved in activation of transcription by the serum response factor.
23165	this protein is essential for differentiation. it may play a role in localizing of nanos (a maternal determinant) activity in oocytes. bicd mutations cause nanos mislocalization and thus bicaudal development.
23166	
23167	binds to cytidine clusters in double-stranded dna.
23168	not known, could be a tyrosine-phosphatase.
23169	receptor for members of the ephrin-a family.
23170	inhibitory regulator of the ras-cyclic amp pathway.
23171	
23172	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
23173	putative rna helicase involved in the second step of rna splicing. may promote one or more conformational changes in the dynamic network of rna-rna interactions in the spliceosome. appears to catalyze an atp-dependent unwinding of u4/u6 rna duplices.
23174	
23175	
23176	
23177	
23178	
23179	
23180	
23181	
23182	
23183	
23184	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. l is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes.
23185	
23186	
23187	
23188	functions in segment determination through interaction with genes of bithorax (bx-c) and antennapedia (ant-c) complexes. it can behave as an activator of bx-c. involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. shown to bind zinc (in vitro).
23189	
23190	general activator of rna polymerase iii transcription.
23191	
23192	
23193	
23194	
23195	this is a probable transcription activator that specifically binds the purine-rich single strand of the pur element located upstream of the c-myc gene. may play a role in the initiation of dna replication and in recombination.
23196	
23197	
23198	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. active on long chain acyl-coas.
23199	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l.
23200	functions in post-golgi recycling pathways. acts as a recycling carrier to the cell surface.
23201	involved in nucleolar processing of pre-18s ribosomal rna. has a role in the nuclear export of 40s pre-ribosomal subunit to the cytoplasm (by similarity).
23202	receptor for thyrothropin. plays a central role in controlling thyroid cell metabolism. the activity of this receptor is mediated by g proteins which activate adenylate cyclase. also acts as a receptor for thyrostimulin (gpa2+gpb5).
23203	plays a role in transcriptional coactivation.
23204	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
23205	
23206	promotes the exchange of gdp by gtp. together with leukocyte antigen-related (lar) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.
23207	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
23208	binds to the intracellular domain of tumor necrosis factor type 1 receptor. the binding domain of trap1 and trap2 resides outside the death domain of tnfr1.
23209	may be involved in vesicular trafficking and neurotransmitter release.
23210	receptor for vegf, vegfb and pgf. has a tyrosine-protein kinase activity. the vegf-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. isoform sflt1 may have an inhibitory role in angiogenesis.
23211	
23212	involved in cytokinesis (potential).
23213	
23214	
23215	
23216	may function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding mad2l1 after it has become dissociated from the mad2l1-cdc20 complex.
23217	drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively. binds f-actin.
23218	stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. may bind polyunsaturated fatty acids.
23219	
23220	transcription factor that, in osteoblasts, activates the decoy receptor for rankl, tnfrsf11b, which in turn regulates osteoclast differentiation. acts in synergy with the wnt- responsive lef1/ctnnb1 pathway. recognizes variations of the palindromic sequence 5@#$%&-attcccnngggaatt-3@#$%&.
23221	regulates eif4e activity by preventing its assembly into the eif4f complex. mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the map kinase pathway.
23222	
23223	
23224	
23225	
23226	
23227	
23228	
23229	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
23230	may convert the inactive conformation of integrin alpha- iib/beta3 to an active form through the binding to the integrin cytoplasmic domain.
23231	
23232	may be an ion-channel regulator. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis. involved in adhesive protein-protein and protein-carbohydrate interactions.
23233	
23234	
23235	
23236	presumably involved in the processing and regular turnover of intracellular proteins. catalyzes the removal of unsubstituted n-terminal amino acids from various peptides.
23237	
23238	
23239	
23240	
23241	
23242	
23243	
23244	
23245	participates in processes of transmission and amplification of the visual signal. cgmp-pdes are the effector molecules in g-protein-mediated phototransduction in vertebrate rods and cones.
23246	
23247	
23248	
23249	
23250	
23251	transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. binds dna on the 5@#$%&-ccac[ga]-3@#$%&half of the er stress response element (erse) (5@#$%&-ccaat-n(9)-ccac[ga]-3@#$%&) and of erse ii (5@#$%&-attgg-n-ccacg-3@#$%&). binding to erse requires binding of nf-y to erse. could also be involved in activation of transcription by the serum response factor.
23252	may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. in association with the sfpq-nono heteromer may play a role in nuclear retention of defective rnas.
23253	
23254	
23255	
23256	
23257	
23258	probably involved in connections of major cytoskeletal structures to the plasma membrane.
23259	collagen type iv is specific for basement membranes.
23260	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
23261	
23262	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
23263	binds gtp, gdp and gmp.
23264	
23265	chemotactic activity for lymphocytes but not for monocytes or neutrophils.
23266	igf-1 leads to the activation of akt3, which may play a role in regulating cell survival. capable of phosphorylating several known proteins. truncated isoform 2/pkb gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
23267	
23268	
23269	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii is composed of at least five proteins: the sec23/24 complex, the sec13/31 complex, and the protein sar1. acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex (by similarity).
23270	
23271	
23272	highly potent vasoconstrictor.
23273	
23274	
23275	
23276	
23277	
23278	
23279	may play a role in transcriptional regulation. binds to and activates cyclin-dependent kinase cdk8 that phosphorylates the ctd (carboxy-terminal domain) of the large subunit of rna polymerase ii (rnap ii).
23280	
23281	
23282	probably plays a role in the formation and regulation of the tight junction (tj) paracellular permeability barrier.
23283	
23284	
23285	
23286	
23287	
23288	required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.
23289	
23290	
23291	
23292	
23293	transcription factor that specifically binds to the octamer motif (5@#$%&-atttgcat-3@#$%&). regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. modulates transcription transactivation by nr3c1, ar and pgr.
23294	likely to play a regulatory role in the development of the ventral forebrain. may play a role in craniofacial patterning and morphogenesis.
23295	involved in iron cellular uptake. seems to be internalized and then recycled back to the cell membrane. binds a single atom of iron per subunit. could also bind zinc.
23296	
23297	
23298	
23299	
23300	
23301	
23302	receptor for the c-x-c chemokine cxcl16. used as a coreceptor by sivs and by strains of hiv-2 and m-tropic hiv-1.
23303	transcriptional repressor that play an important role in the specification and differentiation of lung epithelium.
23304	
23305	
23306	calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. is not activated by phorbol esters or diaglycerol. may play a role in the secretory response to nutrients. involved in cell polarization processes and the formation of epithelial tight junctions.
23307	
23308	
23309	
23310	
23311	
23312	
23313	
23314	
23315	
23316	has a negative effect on cell proliferation (by similarity).
23317	
23318	
23319	may play a role in organizing centrosomal microtubules. may act as a tumor suppressor protein. may represent a tumor progression marker.
23320	
23321	may act as a downstream effector of cdc42 in cytoskeletal reorganization. contributes to the actomyosin contractility required for cell invasion, through the regulation of mypt1 and thus mlc2 phosphorylation (by similarity).
23322	
23323	
23324	
23325	
23326	
23327	
23328	
23329	
23330	
23331	activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (apc/c). during telophase and in the subsequent g1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (d-box) and an additional degradation signal termed the ken box including ase1, cdc20, the b-type cyclins clb2 and clb3, the polo-like kinase cdc5 and hsl1, and recruits them in a c-box-dependent manner to the apc/c for ubiquitination and subsequent proteolysis. required for exit from mitosis, cytokinesis and formation of prereplicative complexes in g1. probably is the target of a bub2-dependent spindle checkpoint pathway.
23332	can act on substrates such as myelin basic protein and histone 2a on serine and threonine residues (by similarity).
23333	
23334	
23335	
23336	
23337	
23338	involved in pre-mrna splicing. facilitates the cooperative formation of u2/u6 helix ii in association with stem ii in the spliceosome. binds to rna.
23339	
23340	
23341	
23342	
23343	
23344	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
23345	
23346	
23347	
23348	
23349	
23350	thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity. coactivates six1, and seems to coactivate six2, six4 and six5. the repression of precursor cell proliferation in myoblasts by six1 is switched to activation through recruitment of eya3 to the six1-dach1 complex and seems to be dependent on eya3 phosphatase activity (by similarity). may be involved in development of the eye.
23351	
23352	
23353	
23354	
23355	
23356	probably plays a role in anchoring the complex to other cellular components.
23357	
23358	
23359	
23360	
23361	
23362	orphan nuclear receptor. binds dna as a monomer to hormone response elements (hre) containing a single core motif half-site preceded by a short a-t-rich sequence. this isomer binds to the consensus sequence 5@#$%&-[at][ta]a[at][cgt]taggtca-3@#$%&.
23363	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
23364	
23365	probable transcriptional activator in the premeiotic germ cells. it binds to the sequences 5@#$%&-aacaat-@#$%&3 or 5@#$%&-aacaaag- 3@#$%& (by similarity).
23366	
23367	
23368	
23369	
23370	demethylates proteins that have been reversibly carboxymethylated. demethylates ppp2cb (in vitro).
23371	
23372	
23373	
23374	
23375	
23376	
23377	
23378	involved in cell adhesion. may be involved in the attachment of the actin-based microfilaments to the plasma membrane.
23379	
23380	
23381	
23382	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking; may modulate vesicle budding and uncoating within the golgi apparatus.
23383	
23384	initiates the extrinsic pathway of blood coagulation. serine protease that circulates in the blood in a zymogen form. factor vii is converted to factor viia by factor xa, factor xiia, factor ixa, or thrombin by minor proteolysis. in the presence of tissue factor and calcium ions, factor viia then converts factor x to factor xa by limited proteolysis. factor viia will also convert factor ix to factor ixa in the presence of tissue factor and calcium (by similarity).
23385	
23386	
23387	
23388	
23389	
23390	
23391	
23392	
23393	seems to have a role in retrograde membrane traffic at the level of the golgi complex.
23394	enhances ar-mediated transactivation. transactivation decreases as the poly-gln length within ar increases.
23395	
23396	
23397	
23398	
23399	acts as a positive regulator of apoptosis.
23400	
23401	
23402	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
23403	
23404	
23405	essential component of the scf (skp1-cul1-f-box protein) e3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. in the scf complex, serves as a rigid scaffold that organizes the skp1-f-box protein and rbx1 subunits. may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
23406	
23407	
23408	
23409	
23410	
23411	
23412	
23413	
23414	differentially targeted protein that binds to type i and ii regulatory subunits of protein kinase a and anchors them to the mitochondria or the plasma membrane. although the physiological relevance between pka and akaps with mitochondria is not fully understood, one idea is that bad, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored pka. it cannot be excluded too that it may facilitate pka as well as g protein signal transduction, by acting as an adapter for assembling multiprotein complexes. with its rgs domain, it could lead to the interaction to g-alpha proteins, providing a link between the signaling machinery and the downstream kinase (by similarity).
23415	
23416	
23417	required for the fusion of plasma membranes and early endosomes.
23418	
23419	
23420	
23421	
23422	
23423	
23424	
23425	
23426	
23427	
23428	splicing factor that in its dephosphorylated form acts as a general repressor of pre-mrna splicing. seems to interfere with the u1 snrnp 5@#$%&-splice recognition of snrp70. required for splicing repression in m-phase cells and after heat shock. may be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
23429	
23430	
23431	
23432	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
23433	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. socs1 is involved in negative regulation of cytokines that signal through the jak/stat3 pathway. through binding to jaks, inhibits their kinase activity. in vitro, also suppresses tec protein- tyrosine activity. appears to be a major regulator of signaling by interleukin 6 (il6) and leukemia inhibitory factor (lif). regulates interferon-gamma mediated sensory neuron survival (by similarity). implicated, through socs box binding, in ubiquitin- dependent protein degradation.
23434	
23435	
23436	
23437	
23438	
23439	
23440	
23441	belongs to the exosome, a rna-processing complex, which is at least involved in the 3@#$%& processing of the 7s pre-rrna to the mature 5.8s rrna. exhibits a 3@#$%&-5@#$%& exoribonuclease activity (by similarity).
23442	
23443	
23444	
23445	probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. may play a role in determining or maintaining the identities of a small subset of visual system neurons.
23446	probably involved in maintaining golgi structure.
23447	involved in axon growth. plays an essential role in neurite extension of cerebellar granule cells.
23448	
23449	
23450	hydrolysis of the deoxyribose n-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged dna polymer formed by alkylation lesions.
23451	it may be responsible for the synthesis of the sequence neuac-alpha-2,3-gal-beta-1,3-galnac- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. siat4a and siat4b sialylate the same acceptor substrates but exhibit different km values.
23452	
23453	
23454	
23455	
23456	
23457	
23458	
23459	
23460	
23461	
23462	acetyltransferase enzyme. acetylates histones, giving a specific tag for transcriptional activation. also acetylates non- histone proteins, like ncoa3 coactivator. mediates camp-gene regulation by binding specifically to phosphorylated creb protein. cbp, as coactivator, augments the activity of phosphorylated creb to activate transcription of camp-responsive genes (by similarity).
23463	
23464	
23465	can stimulate e2f-dependent transcription. binds dna cooperatively with e2f family members through the e2 recognition site, 5@#$%&-tttc[cg]cgc-3@#$%&, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the dp2/e2f complex functions in the control of cell-cycle progression from g1 to s phase. the e2f-1/dp complex appears to mediate both cell proliferation and apoptosis.
23466	
23467	involved in pre-mrna splicing.
23468	
23469	
23470	
23471	
23472	may be involved in retrograde transport of early and late endosomes to the late golgi.
23473	promotes infectivity of neisseria gonorrhoeae in epithelial cells by phosphorylating mcp/cd46.
23474	responsible for methylating the 5@#$%&cap structure of mrnas.
23475	
23476	
23477	
23478	
23479	
23480	
23481	
23482	
23483	
23484	elongation factor that can increase the catalytic rate of rna polymerase ii transcription by suppressing transient pausing by the polymerase at multiple sites along the dna.
23485	may be involved in n-glycosylation through its association with n-oligosaccharyl transferase.
23486	
23487	facilitative glucose transporter. probably a neuronal glucose transporter.
23488	putative adhesion molecule that mediates sialic-acid dependent binding to cells. binds equally to alpha2,3-linked and alpha2,6-linked sialic acid. the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
23489	
23490	
23491	this protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.
23492	
23493	functions as an e3-type small ubiquitin-like modifier (sumo) ligase, stabilizing the interaction between ube2i and the substrate, and as a sumo-tethering factor. plays a crucial role as a transcriptional coregulation in various cellular pathways, including the stat pathway, the p53 pathway, the wnt pathway and the steroid hormone signaling pathway. involved in gene silencing.
23494	
23495	
23496	
23497	
23498	catalyzes the isomerization of prostaglandin h2 to prostacyclin (= prostaglandin i2).
23499	
23500	
23501	
23502	
23503	
23504	
23505	eif-2 functions in the early steps of protein synthesis by forming a ternary complex with gtp and initiator trna. this complex binds to a 40s ribosomal subunit, followed by mrna binding to form a 43s preinitiation complex. junction of the 60s ribosomal subunit to form the 80s initiation complex is preceded by hydrolysis of the gtp bound to eif-2 and release of an eif-2-gdp binary complex. in order for eif-2 to recycle and catalyze another round of initiation, the gdp bound to eif-2 must exchange with gtp by way of a reaction catalyzed by eif-2b.
23506	
23507	highly specific for ethanolamine phosphorylation. may be a rate-controlling step in phosphatidylathanolamine biosynthesis (by similarity).
23508	
23509	
23510	
23511	
23512	plays a role in cytoplasmic trafficking of rna. binds to the cis-acting response element, a2re.
23513	plays a role in cytoplasmic trafficking of rna. binds to the cis-acting response element, a2re.
23514	
23515	
23516	
23517	
23518	
23519	
23520	
23521	
23522	
23523	
23524	collagen type iii occurs in most soft connective tissues along with type i collagen.
23525	
23526	
23527	
23528	
23529	
23530	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein.
23531	
23532	
23533	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
23534	
23535	
23536	
23537	may play a structural role at sites of cell adhesion in maintaining cell shape and motility. in addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. may be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
23538	collagen type iv is specific for basement membranes.
23539	
23540	
23541	
23542	
23543	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
23544	
23545	
23546	
23547	
23548	
23549	
23550	
23551	
23552	
23553	
23554	
23555	
23556	
23557	
23558	
23559	catalyzes the formation of aromatic c18 estrogens from c19 androgens.
23560	
23561	
23562	
23563	
23564	may play a role in cell-cycle regulation during the transition from gamete to embryo (by similarity).
23565	
23566	
23567	involved in cell growth regulation. may be involved in the regulation of mitogenic signals and control of cell proliferation. involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (rtk) type, in particular egfr (by similarity).
23568	
23569	potential transcription factor. may mediate some of the neuroprotective peptide vip-associated effects involving normal growth and cancer proliferation.
23570	
23571	
23572	
23573	may be involved in transcriptional regulation.
23574	
23575	
23576	
23577	
23578	
23579	
23580	part of a multiprotein post-splicing mrnp complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. binds spliced mrna upstream of exon-exon junctions.
23581	
23582	
23583	
23584	
23585	
23586	phosphorylates specifically ribosomal protein s6 in response to insulin or several classes of mitogens.
23587	
23588	
23589	stimulates the transcription of various genes by recognizing and binding to a ccaat motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
23590	may be involved in transferrin trafficking. likely to power actin-based membrane trafficking in many physiologically crucial tissues.
23591	may be involved in transcriptional regulation.
23592	
23593	
23594	may be involved in transcriptional regulation.
23595	
23596	
23597	
23598	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. probably binds g- rich sequences in pre-mrnas.
23599	
23600	glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to g3p and the corresponding alcohols.
23601	
23602	
23603	
23604	
23605	
23606	
23607	
23608	
23609	protein kinase acting as a corepressor of several transcription factors, including smad1 and pou4f1/brn3a and probably nk homeodomain transcription factors. inhibits cell growth and promotes apoptosis. involved in transcriptional activation of tp53 and tp73. phosphorylation of tp53 may be mediated by a tp53-hipk2-axin1 complex. in response to tgfb, cooperates with daxx to activate jnk. phosphorylates the antiapoptotic factor ctbp1 and promotes its proteasomal degradation. in the wnt/beta-catenin signaling pathway acts as an intermediate kinase between tak1 and nlk to promote the proteasomal degradation of c-myb (by similarity).
23610	
23611	
23612	this small ubiquitous enzyme is essential for maintenance and cell growth.
23613	
23614	
23615	
23616	
23617	
23618	
23619	
23620	
23621	plays a critical role in catalyzing the release of class ii hla-associated invariant chain-derived peptides (clip) from newly synthesized class ii hla molecules and freeing the peptide binding site for acquisition of antigenic peptides.
23622	
23623	
23624	
23625	
23626	
23627	
23628	
23629	
23630	
23631	
23632	
23633	
23634	
23635	collagen type iii occurs in most soft connective tissues along with type i collagen.
23636	
23637	
23638	
23639	
23640	
23641	
23642	associated with snrnp u1, u2, u4/u6 and u5.
23643	binds the telomeric double-stranded ttaggg repeat and negatively regulates telomere length. involved in the regulation of the mitotic spindle.
23644	
23645	
23646	
23647	
23648	
23649	
23650	
23651	
23652	
23653	
23654	
23655	
23656	
23657	
23658	
23659	
23660	
23661	
23662	
23663	
23664	
23665	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
23666	
23667	cytokine that binds to tnfrsf1a/tnfr1 and tnfrsf1b/tnfbr. it is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. it is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, under certain conditions it can stimulate cell proliferation and induce cell differentiation.
23668	enhances map3k1 oligomerization, which may relieve amino-terminal mediated map3k1 autoinhibition and lead to activation following autophosphorylation. may play a role in the regulation of vesicle targeting or fusion.
23669	high affinity receptor for semaphorins 3c, 3f, vegf-165 and vegf-145 isoforms of vegf, and the plgf-2 isoform of pgf.
23670	
23671	
23672	
23673	
23674	
23675	
23676	probably involved in cell adhesion. receptor for alphaherpesvirus (hsv-1, hsv-2 and pseudorabies virus) entry into cells.
23677	
23678	
23679	
23680	
23681	catalyzes the covalent attachment of ubiquitin to other proteins. seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (by similarity).
23682	
23683	collagen type iii occurs in most soft connective tissues along with type i collagen.
23684	
23685	
23686	
23687	
23688	
23689	
23690	factor that represses transcription. it binds to the gc- rich sequences (5@#$%&-gcggggc-3@#$%&) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters.
23691	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
23692	
23693	catalyzes the transfer of ptdins and phosphatidylcholine between membranes.
23694	the soluble isoform 2 binds vegf-165 and appears to inhibit its binding to cells. it may also induce apoptosis by sequestering vegf-165. may bind as well various members of the semaphorin family. its expression has an averse effect on blood vessel number and integrity.
23695	
23696	
23697	
23698	plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine.
23699	
23700	
23701	
23702	
23703	
23704	
23705	
23706	
23707	aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
23708	
23709	
23710	
23711	
23712	
23713	
23714	rna-binding protein. required for internal initiation of translation of human rhinovirus rna. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain.
23715	
23716	
23717	
23718	
23719	
23720	
23721	
23722	
23723	
23724	activator of cdk5/tpkii.
23725	
23726	the zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac.
23727	
23728	
23729	
23730	
23731	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
23732	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
23733	
23734	
23735	
23736	regulates the activity of the map kinase family in response to changes in the cellular environment. pyst2-s may act as a negative regulator of pyst2-l although it is unclear whether this is by competing for transcription, translation or activation factors.
23737	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
23738	
23739	
23740	positively regulates a late step in synaptic vesicle exocytosis. also involved in glucose-induced secretion of insulin by pancreatic beta-cells (by similarity).
23741	
23742	
23743	may play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung (by similarity).
23744	the 3beta-hsd enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. hsd vii is active against four 7alpha-hydroxylated sterols. does not metabolize several different c(19/21) steroids as substrates. involved in bile acid synthesis.
23745	
23746	
23747	
23748	
23749	
23750	
23751	in vitro, acts as a receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5).
23752	
23753	may be involved in autophagy-related processes (by similarity).
23754	phosphorylates specifically ribosomal protein s6 in response to insulin or several classes of mitogens.
23755	
23756	
23757	
23758	
23759	
23760	actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells.
23761	
23762	
23763	
23764	binds ldl, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. in order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
23765	
23766	may play a role in the control of gene expression.
23767	
23768	
23769	
23770	
23771	
23772	
23773	
23774	
23775	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules (by similarity).
23776	
23777	
23778	
23779	
23780	
23781	conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (dhea) and androstenedione. catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. involved in sexual development during fetal life and at puberty.
23782	
23783	
23784	
23785	
23786	binds to activated (phosphorylated) protein-tyrosine kinases through its sh2 domain and regulates their kinase activity. during insulin stimulation, it also binds to irs-1.
23787	receptor for il-10; binds il-10 with a high affinity.
23788	
23789	
23790	
23791	
23792	
23793	activates apoptosis and interacts selectively with survival-promoting proteins bcl-2 and bcl-x(l).
23794	
23795	transcriptional repressor.
23796	probable serine protease.
23797	
23798	
23799	
23800	oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
23801	
23802	
23803	
23804	
23805	the electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- coa dehydrogenases, glutaryl-coa and sarcosine dehydrogenase. it transfers the electrons to the main mitochondrial respiratory chain via etf-ubiquinone oxidoreductase (etf dehydrogenase).
23806	
23807	
23808	
23809	
23810	
23811	
23812	e3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by map3k3. potentiates mekk3-mediated activation of the nf-kappa-b, jun/ap1 and ddit3 transcriptional regulators. induces apoptosis when overexpressed.
23813	
23814	component of the peroxisomal translocation machinery with pex13 and pex17. interacts with both the pts1 and pts2 receptors. binds directly to pex17.
23815	
23816	
23817	
23818	protein kinase that act on both serine and threonine residues.
23819	binds to the camp response element and activates transcription.
23820	
23821	srf is a transcription factor that binds to the serum response element (sre), a short sequence of dyad symmetry located 300 bp to the 5@#$%& of the site of transcription initiation of some genes (such as fos).
23822	
23823	
23824	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
23825	
23826	
23827	
23828	
23829	
23830	
23831	
23832	
23833	
23834	
23835	
23836	
23837	complex that is thought to mediate chromatin assembly in dna replication and dna repair. assembles histone octamers onto replicating dna in vitro. caf-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones h3 and h4 to replicating dna; histones h2a/h2b can bind to this chromatin precursor subsequent to dna replication to complete the histone octamer. chaf1a binds to histones h3 and h4. it may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic dna replication foci (by similarity). the ccr4-not complex functions as general transcription regulation complex.
23838	may have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor.
23839	
23840	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression.
23841	type i collagen is a member of group i collagen (fibrillar forming collagen).
23842	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems. the g(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli.
23843	involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. may play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. low-affinity receptor for agouti (by similarity). has a critical role in normal myelination in the central nervous system (by similarity).
23844	binds specifically to the dna sequence 5@#$%&-aacaat-3@#$%&. activates transcription of col2a1 and agc1 in vitro.
23845	
23846	
23847	
23848	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
23849	
23850	promotes the exchange of ras-bound gdp by gtp.
23851	
23852	
23853	protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. necessary for apoptotic membrane blebbing. plays a role in smooth muscle contraction. required for centromere positioning and centromere- dependent exit from mitosis (by similarity).
23854	
23855	
23856	
23857	
23858	may play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. required for sperm motility and male fertility (by similarity).
23859	
23860	
23861	
23862	
23863	
23864	
23865	
23866	
23867	reversible hydration of carbon dioxide.
23868	
23869	
23870	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. combines rna-binding and ppiase activities. may be involved in muscle- and brain-specific processes.
23871	
23872	
23873	may be required for dna interstrand cross-link repair.
23874	
23875	
23876	
23877	
23878	receptor with high affinity for tnfsf2/tnf-alpha and approximately 5-fold lower affinity for homotrimeric tnfsf1/lymphotoxin-alpha. the traf1/traf2 complex recruits the apoptotic suppressors birc2 and birc3 to tnfrsf1b/tnfr2. this receptor mediates most of the metabolic effects of tnf-alpha. isoform 2 blocks tnf-alpha-induced apoptosis, which suggests that it regulates tnf-alpha function by antagonizing its biological activity.
23879	
23880	
23881	
23882	
23883	cytokine that binds to tnfrsf6/fas, a receptor that transduces the apoptotic signal into cells. may be involved in cytotoxic t-cell mediated apoptosis and in t-cell development. tnfrsf6/fas-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature t-cells, or both. binding to the decoy receptor tnfrsf6b/dcr3 modulates its effects.
23884	
23885	
23886	prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
23887	
23888	
23889	
23890	
23891	
23892	promotes the exchange of ras-bound gdp by gtp. this protein positively controls the level of cellular camp at start, the stage at which the yeast cell division cycle is triggered.
23893	
23894	
23895	
23896	calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction.
23897	trap proteins are part of a complex whose function is to bind calcium to the er membrane and thereby regulate the retention of er resident proteins. may be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
23898	
23899	
23900	
23901	
23902	
23903	
23904	
23905	required for protein transport from the er to the golgi complex.
23906	required for the uptake of taurine.
23907	
23908	subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-golgi network (tgn) to the endosomal-lysosomal system.
23909	
23910	
23911	required for neural tube formation. essential for normal heart development and function. acts as a transcriptional repressor of anf by binding to both gata4 and nkx2-5 and repressing their transcriptional activator activities. participates in the negative regulation of cell proliferation signaling (by similarity).
23912	major airway glycoprotein.
23913	
23914	plays a central role as a glucosyl donor in cellular metabolic pathways.
23915	
23916	
23917	
23918	
23919	
23920	
23921	may act as a lysosomal receptor.
23922	
23923	
23924	
23925	
23926	
23927	
23928	inactivates paf by removing the acetyl group at the sn-2 position. this is a catalytic subunit. plays an important role during the development of brain.
23929	
23930	
23931	
23932	
23933	
23934	protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function.
23935	
23936	
23937	
23938	
23939	this is a receptor for retinoic acid. this metabolite has profound effects on vertebrate development. retinoic acid is a morphogen and is a powerful teratogen. this receptor controls cell function by directly regulating gene expression.
23940	
23941	
23942	
23943	
23944	
23945	
23946	
23947	
23948	
23949	one gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low mw diffuse from one cell to a neighboring cell. may play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.
23950	
23951	
23952	
23953	
23954	
23955	
23956	receptor for members of the ephrin-b family.
23957	may act as a tumor suppressor.
23958	
23959	attaches integral membrane proteins to cytoskeletal elements. also binds to cytoskeletal proteins. required for coordinate assembly of na/ca exchanger, na/k atpase and insp3 receptor at sarcoplasmic reticulum sites in cardiomyocytes.
23960	
23961	
23962	may play a role in intracellular transport of gaba(a) receptors and its interaction with the cytoskeleton (by similarity).
23963	f-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. this is a bundling protein (by similarity).
23964	
23965	
23966	
23967	
23968	
23969	
23970	
23971	
23972	
23973	
23974	
23975	
23976	
23977	
23978	
23979	
23980	
23981	
23982	
23983	
23984	
23985	growth factor for endothelial cells. vegf-b167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of vegf-b186 is regulated by proteolysis.
23986	may be involved in transcriptional regulation. coactivator for steroid receptors.
23987	
23988	
23989	
23990	
23991	
23992	may be involved in transcriptional regulation.
23993	
23994	
23995	
23996	
23997	
23998	
23999	
24000	
24001	
24002	
24003	
24004	
24005	may function in membrane trafficking. exhibits calcium- dependent phospholipid binding properties (by similarity).
24006	regulates myosin phosphatase activity.
24007	
24008	probably involved in synaptic functions in the cns.
24009	
24010	collagen type iv is specific for basement membranes.
24011	binds to cug triplet repeat expansion dsrna (by similarity).
24012	
24013	
24014	
24015	
24016	facilitative glucose transporter (by similarity).
24017	functions as a master transcriptional regulator of the adaptive response to hypoxia. under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. binds to core dna sequence 5@#$%&-[ag]cgtg-3@#$%& within the hypoxia response element (hre) of target gene promoters. activation requires recruitment of transcriptional coactivators such as crebpb and ep300. activity is enhanced by interaction with both, ncoa1 or ncoa2. interaction with redox regulatory protein apex seems to activate ctad and potentiates activation by ncoa1 and crebbp.
24018	
24019	
24020	
24021	thiol protease which is believed to participate in intracellular degradation and turnover of proteins. has also been implicated in tumor invasion and metastasis.
24022	
24023	
24024	
24025	catalyzes the irreversible nadph-dependent deamination of gmp to imp. it functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of g to a nucleotides, and in maintaining the intracellular balance of a and g nucleotides. plays a role in modulating cellular differentiation.
24026	
24027	mediates endoplasmic reticulum to golgi transport (by similarity).
24028	
24029	
24030	
24031	
24032	
24033	
24034	
24035	
24036	
24037	
24038	
24039	
24040	
24041	
24042	produces nitric oxide (no) which is a messenger molecule with diverse functions throughout the body. in macrophages, no mediates tumoricidal and bactericidal actions.
24043	may be involved in transcriptional regulation.
24044	gtp-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an adp- ribosyltransferase. involved in protein trafficking among different compartments. modulates vesicle budding and uncoating within the golgi complex. deactivation induces the redistribution of the entire golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. in its gtp-bound form, its triggers the association with coat proteins with the golgi membrane. the hydrolysis of arf1-bound gtp, which is mediated by arfgaps proteins, is required for dissociation of coat proteins from golgi membranes and vesicles.
24045	
24046	
24047	
24048	drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. may also be linked to the malignant phenotype.
24049	
24050	
24051	
24052	
24053	
24054	
24055	favors the reduction of estrogens and androgens. also has 20-alpha-hsd activity. uses preferentially nadh.
24056	
24057	
24058	
24059	
24060	
24061	
24062	
24063	
24064	receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-coa oxidase and activates its transcription. it therefore controls the peroxisomal beta-oxidation pathway of fatty acids.
24065	inhibits primary neurogenesis. may be required to divert neurons along a specific differentiation pathway. plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (by similarity).
24066	may be involved in transcriptional regulation.
24067	
24068	
24069	
24070	
24071	
24072	
24073	
24074	transcriptional activator. binds to fat body-specific enhancers of alcohol dehydrogenase (adh) and yolk protein genes. bbf-2 may play a role in fat body gene expression. it binds the consensus sequence 5@#$%&-t[ac]nacgtan[tg]c-3@#$%&.
24075	
24076	
24077	collagen type iii occurs in most soft connective tissues along with type i collagen.
24078	
24079	
24080	
24081	
24082	adenosylhomocysteine is a competitive inhibitor of s- adenosyl-l-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
24083	
24084	
24085	
24086	
24087	
24088	recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (by similarity).
24089	
24090	glandular kallikreins cleave met-lys and arg-ser bonds in kininogen to release lys-bradykinin.
24091	
24092	
24093	
24094	
24095	
24096	
24097	receptor for vegf, vegfb and pgf. has a tyrosine-protein kinase activity. the vegf-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. isoform sflt1 may have an inhibitory role in angiogenesis.
24098	cell surface proteoglycan that bears heparan sulfate. may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. may play a role in the modulation of igf2 interactions with its receptor and thereby modulate its function. may regulate growth and tumor predisposition.
24099	
24100	
24101	l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists. this receptor binds kainate > quisqualate = glutamate >> ampa.
24102	l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists. this receptor binds kainate > quisqualate = glutamate >> ampa.
24103	serum albumin, the main protein of plasma, has a good binding capacity for water, ca(2+), na(+), k(+), fatty acids, hormones, bilirubin and drugs. its main function is the regulation of the colloidal osmotic pressure of blood.
24104	essential component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. recruits mitochondrial hsp70 to drive protein translocation into the matrix using atp as an energy source.
24105	acts as a transcriptional repressor.
24106	
24107	
24108	this is a calmodulin-sensitive adenylyl cyclase. may be involved in regulatory processes in the central nervous system. it may play a role in memory acquisition and learning.
24109	
24110	
24111	
24112	
24113	
24114	
24115	
24116	
24117	
24118	involved in the morphogenesis of the adult appendages. gtpase-activating protein for p21-rac. promotes the exchange of rac-bound gdp by gtp.
24119	
24120	
24121	this protein is a minor sialoglycoprotein in human erythrocyte membranes. the blood group gerbich antigens and receptors for plasmodium falciparum merozoites are most likely located within the extracellular domain. glycophorin c plays an important role in regulating the stability of red cells.
24122	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
24123	
24124	
24125	
24126	involved in ph regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. major proton extruding system driven by the inward sodium ion chemical gradient. plays an important role in signal transduction.
24127	involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26s proteasome (by similarity).
24128	
24129	
24130	
24131	
24132	
24133	
24134	
24135	
24136	
24137	
24138	
24139	putative odorant receptor.
24140	
24141	
24142	binds to gt and gc boxes promoters elements. probable transcriptional activator.
24143	
24144	
24145	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
24146	inhibitor of protein-phosphatase 1.
24147	
24148	
24149	
24150	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
24151	
24152	probable transcription regulator.
24153	
24154	
24155	
24156	
24157	
24158	
24159	
24160	
24161	
24162	
24163	
24164	
24165	transcriptional repressor.
24166	cytokine that binds to tnfrsf9. induces the proliferation of activated peripheral blood t-cells. may have a role in activation-induced cell death (aicd). may play a role in cognate interactions between t-cells and b-cells/macrophages.
24167	
24168	
24169	
24170	
24171	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
24172	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
24173	
24174	
24175	
24176	
24177	cytokine that binds to tnfrsf8/cd30. induces proliferation of t-cells.
24178	subunit of the splicing factor sf3a required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex.
24179	
24180	
24181	
24182	
24183	
24184	
24185	
24186	
24187	
24188	
24189	
24190	
24191	
24192	
24193	
24194	
24195	
24196	
24197	
24198	
24199	
24200	
24201	
24202	
24203	receptor on natural killer (nk) cells for hla-c alleles. does not inhibit the activity of nk cells.
24204	
24205	
24206	signaling adapter that couples activated growth factor receptors to signaling pathway. isoform p46shc and isoform p52shc, once phosphorylated, couple activated receptor tyrosine kinases to ras via the recruitment of the grb2/sos complex and are implicated in the cytoplasmic propagation of mitogenic signals. isoform p46shc and isoform p52shc may thus function as initiators of the ras signaling cascade in various nonneuronal systems. isoform p66shc does not mediate ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. isoform p66shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. the expression of isoform p66shc has been correlated with life span (by similarity).
24207	
24208	tumor suppressor. it blocks the growth, invasion, and metastatic properties of mammary tumors. as it does not undergo the s (stressed) to r (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
24209	
24210	
24211	
24212	regulates the differentiation and proliferation of normal cells through the regulation of cell death.
24213	histone h3, along with histone h4, plays a central role in nucleosome formation.
24214	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
24215	
24216	
24217	
24218	may be involved in the physiological processes of brain function. has no dipeptidyl aminopeptidase activity. may modulate the cell surface expression and the activity of the potassium channel kcnd2 (by similarity).
24219	
24220	
24221	
24222	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
24223	
24224	
24225	
24226	
24227	
24228	
24229	
24230	
24231	
24232	
24233	component of a protein kinase signal transduction cascade. regulates the jnk and erk5 pathways by phosphorylating and activating map2k5 and map2k7. plays a role in caveolae kiss- and-run dynamics (by similarity).
24234	
24235	
24236	
24237	
24238	the soluble isoform 2 binds vegf-165 and appears to inhibit its binding to cells. it may also induce apoptosis by sequestering vegf-165. may bind as well various members of the semaphorin family. its expression has an averse effect on blood vessel number and integrity.
24239	
24240	motor for anterograde axonal transport of synaptic vesicle precursors (by similarity).
24241	
24242	
24243	
24244	
24245	
24246	
24247	
24248	
24249	
24250	
24251	
24252	
24253	
24254	branching enzyme that converts linear into branched poly-n-acetyllactosaminoglycans. introduces the blood group i antigen during embryonic development. it is closely associated with the development and maturation of erythroid cells.
24255	
24256	receptor for atrial natriuretic peptide (anp), brain natriuretic peptide (bnp), and c-type natriuretic peptide (cnp). has guanylate cyclase activity on binding of ligand. the activation order seems to be cnp > bnp > anp.
24257	
24258	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
24259	
24260	may be involved in transcriptional regulation. coactivator for steroid receptors.
24261	calcium-binding protein. may have a role in calcium homeostasis.
24262	
24263	
24264	
24265	
24266	
24267	
24268	
24269	
24270	calcium-binding protein required for t-cell receptor-, fas-, and glucocorticoid-induced cell death. may mediate ca(2+)- regulated signals along the death pathway (by similarity).
24271	
24272	
24273	tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. phosphorylates stat6, irs1, irs2 and pi3k.
24274	
24275	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
24276	
24277	causes the formation of thin, actin-rich surface projections called filopodia. functions cooperatively with cdc42 and rac to generate additional structures, increasing the diversity of actin-based morphology.
24278	gfap, a class-iii intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
24279	muscle contraction.
24280	
24281	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
24282	
24283	may function as a complex with the chimeric protein runx1/aml1-cbfa2t1/mtg8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). may thus be involved in the repression of aml1-dependent transcription and the induction of g-csf/csf3-dependent cell growth. may be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.
24284	
24285	integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence g-f-p-g-e-r in collagen. integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-v/beta-1 are receptors for fibronectin. alpha-4/beta-1 recognizes one or more domains within the alternatively spliced cs-1 and cs-5 regions of fibronectin. integrin alpha-5/beta-1 is a receptor for fibrinogen. integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. integrin alpha-4/beta-1 is a receptor for vcam1. it recognizes the sequence q-i-d-s in vcam1. integrin alpha-9/beta-1 is a receptor for vcam1, cytotactin and osteopontin. it recognizes the sequence a-e-i-d-g-i-e-l in cytotactin. integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and cspg4. alpha-3/beta-1 may mediate with lgals3 the stimulation by cspg4 of endothelial cells migration. integrin alpha-v/beta-1 is a receptor for vitronectin. beta-1 integrins recognize the sequence r-g-d in a wide array of ligands. isoform beta-1b interferes with isoform beta-1a resulting in a dominant negative effect on cell adhesion and migration (in vitro).
24286	
24287	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
24288	
24289	
24290	
24291	
24292	
24293	
24294	
24295	
24296	
24297	
24298	
24299	
24300	
24301	may be an ion-channel regulator. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis. involved in adhesive protein-protein and protein-carbohydrate interactions.
24302	stimulates transcription from the hsp70 promoter.
24303	
24304	
24305	
24306	
24307	
24308	
24309	
24310	
24311	
24312	
24313	
24314	
24315	
24316	
24317	
24318	
24319	
24320	
24321	in addition to its role as a glycolytic enzyme, it seems that pgk-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
24322	
24323	binds to disheveled (dvl) and rho, and mediates wnt- induced dvl-rho complex formation. may play a role as a scaffolding protein to recruit rho-gdp and rho-gef, thereby, enhancing rho-gtp formation.
24324	
24325	
24326	
24327	
24328	adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. can bind to fibrinogen, fibronectin, laminin and type v collagen.
24329	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. utilizes a wide range of saturated fatty acids with a preference for c16-c18 unsaturated fatty acids (by similarity).
24330	mediates electroneutral potassium-chloride cotransport when activated by cell swelling. may mediate k(+) uptake into deiters@#$%& cells in the cochlea and contribute to k+ recycling in the inner ear. important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of corti. may be required for basolateral cl(-) extrusion in the kidney and contribute to renal acidification (by similarity).
24331	
24332	
24333	
24334	
24335	
24336	may play a role in cell-cycle regulation during the transition from gamete to embryo (by similarity).
24337	
24338	integrin alpha-9/beta-1 is a receptor for vcam1, cytotactin and osteopontin. it recognizes the sequence a-e-i-d-g- i-e-l in cytotactin.
24339	
24340	
24341	
24342	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
24343	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
24344	involved in the regulation of cell adhesion and in signal transduction through the wnt pathway.
24345	
24346	rapidly hydrolyzes choline released into the synapse.
24347	
24348	
24349	binds and activates tie2 receptor by inducing its tyrosine phosphorylation. implicated in endothelial developmental processes later and distinct from that of vegf. appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. mediates blood vessel maturation/stability. it may play an important role in the heart early development.
24350	
24351	cleaves the c-terminal propeptides of procollagen i, ii and iii. induces cartilage and bone formation.
24352	
24353	
24354	
24355	
24356	
24357	
24358	
24359	
24360	
24361	gtpase-activating protein for the adp ribosylation factor family (by similarity).
24362	potassium channel activated by both membrane depolarization or increase in cytosolic ca(2+) that mediates export of k(+). it is also activated by the concentration of cytosolic mg(2+). its activation dampens the excitatory events that elevate the cytosolic ca(2+) concentration and/or depolarize the cell membrane. it therefore contributes to repolarization of the membrane potential. plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. in smooth muscles, its activation by high level of ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. in cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. kinetics of kcnma1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. highly sensitive to both iberiotoxin (ibtx) and charybdotoxin (ctx).
24363	
24364	
24365	
24366	
24367	
24368	this receptor is controlled by g proteins. inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. the inward rectification is mainly due to the blockage of outward current by internal magnesium. can be blocked by extracellular barium and cesium (by similarity).
24369	
24370	
24371	
24372	
24373	
24374	
24375	plays an important role in the degradation of dermatan and keratan sulfates.
24376	
24377	
24378	
24379	involved in ubiquitination and subsequent proteasomal degradation of target proteins. plays a role in the polyubiquitination of cdt1 in response to radiation-induced dna damage.
24380	transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. crucial in the maintenance of the thyroid differentiation phenotype. may play a role in lung development and surfactant homeostasis.
24381	
24382	probably involved in the repair of mismatches in dna.
24383	
24384	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
24385	
24386	
24387	
24388	the protein is required for polarized cell growth.
24389	
24390	
24391	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna (by similarity).
24392	
24393	
24394	
24395	
24396	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
24397	
24398	
24399	
24400	
24401	
24402	
24403	the function of the small subunit is not yet clear.
24404	
24405	
24406	
24407	probable inhibitory regulator of the ras-cyclic amp pathway.
24408	
24409	
24410	
24411	
24412	
24413	
24414	
24415	
24416	
24417	
24418	part of the postsynaptic scaffold in neuronal cells.
24419	acts upon elastin.
24420	
24421	
24422	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (by similarity). this protein may be involved in maturation and/or post-transcriptional regulation of mrna. may play a role in control of cell cycle progression. may have tumor suppressor function. regulates dna topoisomerase ii binding protein (topbp1) for the dna damage response. plays an essential role in extraembryonic development.
24423	integrin alpha-l/beta-2 is a receptor for icam1, icam2, icam3 and icam4. integrins alpha-m/beta-2 and alpha-x/beta-2 are receptors for the ic3b fragment of the third complement component and for fibrinogen. integrin alpha-x/beta-2 recognizes the sequence g-p-r in fibrinogen alpha-chain. integrin alpha-m/beta-2 recognizes p1 and p2 peptides of fibrinogen gamma chain. integrin alpha-m/beta-2 is also a receptor for factor x. integrin alpha- d/beta-2 is a receptor for icam3 and vcam1.
24424	
24425	
24426	collagen type iii occurs in most soft connective tissues along with type i collagen.
24427	
24428	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes (by similarity).
24429	
24430	probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as notch receptors and app (beta-amyloid precursor protein). requires the other members of the gamma-secretase complex to have a protease activity. may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. may function in the cytoplasmic partitioning of proteins.
24431	
24432	binds to the gm-csf promoter. seems to act as a repressor. binds also to full length mrna and to short rna sequences containing the consensus site 5@#$%&-uccauca-3@#$%&. may have a role in translation repression (by similarity).
24433	
24434	
24435	directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mrna localization and the establishment of cell polarity.
24436	
24437	
24438	
24439	oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
24440	terminal component of the liver microsomal stearyl-coa desaturase system, that utilizes o(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-coa substrates including palmitoyl-coa and stearoyl-coa.
24441	
24442	
24443	
24444	involved in the maturation of asn-linked oligosaccharides. progressively trim alpha-1,2-linked mannose residues from man(9)glcnac(2) to produce man(5)glcnac(2).
24445	
24446	
24447	
24448	fabp are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-coa esters.
24449	
24450	associated with snrnp u1, u2, u4/u6 and u5.
24451	
24452	
24453	
24454	involved in intracellular signal transduction mediated by cytokines and growth factors. probably acts via its association with ubiquitinated cargo proteins on the early endosome participates in their sorting for trafficking to the lysosome. upon il-2 and gm-csl stimulation, it plays a role in signaling leading to dna synthesis and c-myc induction. may also play a in t-cell development (by similarity).
24455	
24456	catalyzes the posttranslational addition of a tyrosine to the c-terminal end of detyrosinated alpha-tubulin.
24457	
24458	
24459	
24460	
24461	
24462	
24463	
24464	
24465	
24466	
24467	gtpase-activating protein for rac1 and perhaps cdc42, but not for rhoa small gtpase. may attenuate rac1 signaling in neurons.
24468	
24469	
24470	
24471	gtpase-activating protein for the adp ribosylation factor family (potential).
24472	
24473	
24474	inhibitor of protein-phosphatase 1.
24475	
24476	tumor-associated antigen.
24477	
24478	the long isoform may play a role in neural and glial cell adhesion in the developing embryo. the short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. vital for embryonic development. essential for septate junctions. septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. required for the blood-brain barrier formation.
24479	
24480	
24481	
24482	
24483	
24484	essential subunit of n-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an asn-x-ser/thr consensus motif in nascent polypeptide chains.
24485	
24486	
24487	
24488	
24489	
24490	may be involved in transcriptional regulation.
24491	
24492	
24493	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. receptor for bmps/op-1.
24494	
24495	
24496	
24497	
24498	
24499	
24500	
24501	may play a role in the control of gene expression.
24502	this enzyme condenses acetyl-coa with acetoacetyl-coa to form hmg-coa, which is the substrate for hmg-coa reductase.
24503	
24504	low concentration of a soluble form of interleukin-6 receptor acts as an agonist of il6 activity.
24505	
24506	
24507	
24508	
24509	
24510	
24511	
24512	
24513	
24514	involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. binds to a palindromic site (called t site) and activates gene transcription when bound to such a site.
24515	
24516	
24517	
24518	
24519	
24520	seems to act exclusively upon threonine residues (by similarity).
24521	
24522	
24523	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
24524	
24525	
24526	
24527	
24528	
24529	
24530	
24531	subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. the ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
24532	
24533	mediates the splicing of pre-mrna by binding to the loop i region of u1-snrna. the truncated isoforms cannot bind u1-snrna.
24534	part of the tip60 chromatin-remodelling complex which is involved in dna repair. upon induction of dna double-strand breaks, this complex acetylates phosphorylated h2av in nucleosomes and exchanges it with unmodified h2av.
24535	this protein promotes the gtp-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome.
24536	
24537	
24538	
24539	
24540	part of the ap-3 complex, an adaptor-related complex which is not clathrin-associated. the complex is associated with the golgi region as well as more peripheral structures. it facilitates the budding of vesicles from the golgi membrane and may be directly involved in trafficking to lysosomes.
24541	
24542	
24543	
24544	may function in membrane trafficking. exhibits calcium- dependent phospholipid binding properties (by similarity). seems to have a protein kinase activity.
24545	
24546	may play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
24547	
24548	
24549	insulin-regulated facilitative glucose transporter. binds cytochalasin b in a glucose-inhibitable manner. seems to be a dual-specific sugar transporter as it is inhibitable by fructose (by similarity).
24550	involved in the maintenance of proximal germ cells by supporting their proliferation. probably regulates translation of specific mrnas by associating with the 3@#$%& untranslated regions (utrs) of mrna targets (by similarity).
24551	
24552	aldhs play a major role in the detoxification of alcohol-derived acetaldehyde. they are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
24553	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
24554	
24555	
24556	
24557	
24558	
24559	
24560	involved in t-cell antigen receptor mediated signaling.
24561	
24562	
24563	
24564	
24565	
24566	
24567	
24568	
24569	
24570	
24571	
24572	
24573	
24574	
24575	
24576	
24577	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
24578	
24579	
24580	
24581	
24582	
24583	
24584	
24585	
24586	
24587	
24588	
24589	
24590	
24591	
24592	
24593	
24594	
24595	
24596	
24597	may be involved in transcriptional regulation.
24598	
24599	
24600	
24601	
24602	
24603	
24604	
24605	
24606	motor required for the retrograde transport of golgi vesicles to the endoplasmic reticulum. has a microtubule plus end- directed motility.
24607	
24608	may act as a molecular switch during maturation of the 40s ribosomal subunit in the nucleolus (by similarity).
24609	sodium-phosphate symporter. active in early growth phase.
24610	
24611	
24612	
24613	
24614	
24615	
24616	
24617	
24618	
24619	regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating rho-like gtpases. is likely a factor in the cascade of rac1 or cdc42 in the neurons.
24620	
24621	
24622	
24623	
24624	
24625	
24626	
24627	
24628	
24629	
24630	
24631	
24632	integrin alpha-iib/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. it recognizes the sequence r-g-d in a wide array of ligands. it recognizes the sequence h-h-l-g-g-g-a-k-q-a-g-d-v in fibrinogen gamma chain. following activation integrin alpha- iib/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. this step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
24633	
24634	
24635	
24636	
24637	
24638	
24639	
24640	may be involved in the physiological processes of brain function. has no dipeptidyl aminopeptidase activity. may modulate the cell surface expression and the activity of the potassium channel kcnd2 (by similarity).
24641	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
24642	
24643	collagen type iii occurs in most soft connective tissues along with type i collagen.
24644	
24645	
24646	
24647	
24648	
24649	not known. used by poliovirus to bind and enter the cell.
24650	
24651	
24652	
24653	
24654	
24655	
24656	
24657	
24658	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
24659	recognizes and binds the palindromic sequence 5@#$%&- ttggcnnnnngccaa-3@#$%& present in viral and cellular promoters and in the origin of replication of adenovirus type 2. these proteins are individually capable of activating transcription and replication.
24660	
24661	involved in cdc48-dependent protein degradation through the ubiquitin/proteasome pathway. direct or indirect positive regulator of glc7 activity.
24662	
24663	
24664	
24665	
24666	
24667	
24668	cbf binds to the core site, 5@#$%&-pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, lck, il-3 and gm-csf promoters. the alpha subunit binds dna and appears to have a role in the development of normal hematopoiesis. isoform aml-1l interferes with the transactivation activity of runx1. acts synergistically with elf4 to transactivate the il-3 promoter and with elf2 to transactivate the mouse blk promoter. inhibits myst4- dependent transcriptional activation.
24669	required for synthesis of pyridoxal-5-phosphate from vitamin b6.
24670	
24671	
24672	
24673	
24674	
24675	
24676	during embryonic development, some isoforms are essential for proper neuronal differentiation and organization. required for cell polarity; maintenance of apicobasal polarity. plays a critical role at septate junctions in cellular growth control during larval development. the presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
24677	component of cohesin complex, a complex required for the cohesion of sister chromatids after dna replication. the cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. at anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. the cohesin complex may also play a role in spindle pole assembly during mitosis.
24678	required for protein transport from the er to the golgi complex.
24679	
24680	
24681	
24682	
24683	
24684	
24685	
24686	integrin alpha-1/beta-1 is a receptor for laminin and collagen. it recognizes the proline-hydroxylated sequence g-f-p-g- e-r in collagen.
24687	transcription factor that activates the expression of the eif2s1 (eif2-alpha) gene. links the transcriptional modulation of key metabolic genes to cellular growth and development. implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial dna transcription and replication.
24688	
24689	
24690	
24691	
24692	
24693	
24694	
24695	
24696	
24697	
24698	
24699	
24700	may transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of n-linked oligosaccharides of glycoproteins and may be involved in psa (polysialic acid) expression.
24701	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
24702	
24703	
24704	
24705	
24706	
24707	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. srp9 together with srp14 and the alu portion of the srp rna, constitutes the elongation arrest domain of srp. the complex of srp9 and srp14 is required for srp rna binding.
24708	
24709	
24710	
24711	
24712	
24713	
24714	
24715	suppresses neurite outgrowth (by similarity).
24716	
24717	essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.
24718	
24719	
24720	
24721	
24722	
24723	
24724	
24725	
24726	
24727	
24728	
24729	binds the sequence 5@#$%&-atcaatcaa-3@#$%&. acts as a transcriptional activator of pf4 in complex with meis1. converted into a potent transcriptional activator by the (1;19) translocation. may have a role in steroidogenesis and, subsequently, sexual development and differentiation.
24730	
24731	
24732	may be involved in the final steps of mitochondrial differentiation within the flagellum.
24733	
24734	
24735	
24736	
24737	
24738	
24739	
24740	
24741	
24742	
24743	phosphorylates serine- and arginine-rich (sr) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable sr proteins to control rna splicing. phosphorylates serines, threonines and tyrosines (by similarity).
24744	sodium-independent, high-affinity transport of large neutral amino acids. has higher affinity for l-phenylalanine that lat1. l-alanine is transported at physiological concentrations. plays a role in basolateral (re)absorption of neutral amino acids.
24745	
24746	
24747	
24748	
24749	
24750	
24751	
24752	represses hepatitis b virus (hbv) core promoter activity and transcription of hbv genes and production of hbv virions. binds to the consensus dna sequence: 5@#$%&-ga[gt]an[cg][ag]cc-3@#$%&. might protect cells from apoptosis. might be involved in pre-mrna splicing (by similarity).
24753	
24754	
24755	
24756	
24757	type i collagen is a member of group i collagen (fibrillar forming collagen).
24758	
24759	
24760	
24761	
24762	
24763	tumor-associated antigen.
24764	high specificity for fatty acids. highest affinity for c18 chain length. decreasing the chain length or introducing double bonds reduces the affinity. may be involved in keratinocyte differentiation.
24765	
24766	
24767	
24768	may be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
24769	transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+) (by similarity).
24770	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
24771	catalyzes the s-methylation of thiopurine drugs such as 6-mercaptopurine.
24772	
24773	
24774	
24775	
24776	
24777	
24778	
24779	
24780	
24781	
24782	
24783	
24784	
24785	
24786	
24787	
24788	
24789	
24790	
24791	
24792	
24793	
24794	
24795	
24796	
24797	
24798	may be involved in transcriptional regulation.
24799	
24800	
24801	
24802	
24803	
24804	
24805	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
24806	
24807	
24808	mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient. it is a tetrodotoxin-sensitive na(+) channel isoform. plays a role in pain mechanisms, especially in the development of inflammatory pain (by similarity).
24809	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
24810	
24811	
24812	type i collagen is a member of group i collagen (fibrillar forming collagen).
24813	guanine nucleotide exchange factor (gef) for rap1a, rap1b and rap2b gtpases. does not interact with camp or cgmp.
24814	
24815	
24816	
24817	
24818	
24819	
24820	
24821	
24822	
24823	
24824	
24825	
24826	
24827	
24828	
24829	
24830	
24831	
24832	
24833	the gamma subunit has a critical role in allowing the ige fc receptor to reach the cell surface.
24834	
24835	
24836	
24837	may be involved in transcriptional regulation.
24838	
24839	
24840	microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. most probably involved in vesicular trafficking processes, in particular endocytosis.
24841	likely to play a regulatory role in the development of the ventral forebrain. may play a role in craniofacial patterning and morphogenesis.
24842	binds to dna at special at-rich sequences at nuclear matrix- or scaffold-associated regions. thought to recognize the sugar-phosphate structure of double-stranded dna.
24843	may be involved in transcriptional regulation.
24844	
24845	
24846	
24847	similar to that of somatotropin.
24848	transcriptional repressor.
24849	
24850	protein kinase acting as a corepressor of several transcription factors, including smad1 and pou4f1/brn3a and probably nk homeodomain transcription factors. inhibits cell growth and promotes apoptosis. involved in transcriptional activation of tp53 and tp73. phosphorylation of tp53 may be mediated by a tp53-hipk2-axin1 complex. in response to tgfb, cooperates with daxx to activate jnk. phosphorylates the antiapoptotic factor ctbp1 and promotes its proteasomal degradation. in the wnt/beta-catenin signaling pathway acts as an intermediate kinase between tak1 and nlk to promote the proteasomal degradation of c-myb (by similarity).
24851	
24852	
24853	
24854	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
24855	uridine diphosphate-n-acetylglucosamine transporter in the golgi apparatus.
24856	
24857	
24858	
24859	
24860	ca(2+)-regulated actin-binding protein.
24861	
24862	in cooperation with other chaperones, hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. these chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. they bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
24863	putative odorant receptor.
24864	
24865	
24866	
24867	
24868	
24869	
24870	
24871	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules.
24872	
24873	type iv collagen is the major structural component of glomerular basement membranes (gbm), forming a @#$%&chicken-wire@#$%& meshwork together with laminins, proteoglycans and entactin/nidogen.
24874	
24875	
24876	involved in regulating eumelanin and phaeomelanin levels.
24877	
24878	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
24879	
24880	connects cell membrane constituents to the actin cytoskeleton. may promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. anchors various transmembrane proteins to the actin cytoskeleton. interaction with flna may allow neuroblast migration from the ventricular zone into the cortical plate. various interactions and localizations of isoforms affect myotube morphology and myogenesis. isoform 6 accelerates muscle differentiation in vitro.
24881	
24882	may be involved in transcriptional regulation.
24883	
24884	
24885	stimulates specifically the gtpase activity of ypt6.
24886	type i collagen is a member of group i collagen (fibrillar forming collagen).
24887	
24888	
24889	
24890	associated to surface igm-receptor; may be involved in signal transduction. may be involved in regulation of the catalytic activity of type 2a-related serine/threonine phosphatases.
24891	
24892	signaling adapter that couples activated growth factor receptors to signaling pathway. isoform p46shc and isoform p52shc, once phosphorylated, couple activated receptor tyrosine kinases to ras via the recruitment of the grb2/sos complex and are implicated in the cytoplasmic propagation of mitogenic signals. isoform p46shc and isoform p52shc may thus function as initiators of the ras signaling cascade in various nonneuronal systems. isoform p66shc does not mediate ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. isoform p66shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. the expression of isoform p66shc has been correlated with life span (by similarity).
24893	
24894	
24895	
24896	
24897	
24898	
24899	
24900	collagen type iii occurs in most soft connective tissues along with type i collagen.
24901	
24902	laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha- 6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-fak and p80, (3) differentiation of keratinocytes.
24903	
24904	
24905	binds double-stranded dna. binds dinucleosomes, probably at the linker region between neighboring nucleosomes. plays a role in chromatin remodeling (by similarity). required for the function of some acidic activation domains, which activate transcription from a distant site.
24906	
24907	
24908	
24909	pre-mrna processing factor involved in disassembly of spliceosomes after the release of mature mrna (by similarity).
24910	muscle contraction.
24911	
24912	functions as an e3-type small ubiquitin-like modifier (sumo) ligase, stabilizing the interaction between ube2i and the substrate, and as a sumo-tethering factor. plays a crucial role as a transcriptional coregulation in various cellular pathways, including the stat pathway and the steroid hormone signaling pathway. the effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
24913	
24914	
24915	
24916	
24917	
24918	aminopeptidase with broad substrate specificity to several peptides. involved in proteolytic events essential for cell growth and viability. may act as regulator of neuropeptide activity (by similarity).
24919	component of the circadian clock or downstream effector of clock function. exhibits a high amplitude circadian rhythm with maximal levels in early evening. in constant darkness or constant light, the amplitude of the rhythm decreases (by similarity).
24920	
24921	
24922	
24923	
24924	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex (by similarity).
24925	actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. may be down-regulated in neuroblastoma tumors.
24926	
24927	essential component of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. when overexpressed in cells induces the formation of cytoplasmic annulate lamellae (al) (by similarity).
24928	
24929	probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. may act by preventing binding of positively-activing ccaat factors to promoters. plays an essential role in lung maturation (by similarity).
24930	
24931	
24932	
24933	
24934	
24935	binds preferentially single-stranded dna and unwinds double stranded dna.
24936	
24937	transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. cbf binds to the core site, 5@#$%&- pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(i) collagen, lck, il-3 and gm-csf promoters (by similarity). inhibits myst4-dependent transcriptional activation.
24938	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (by similarity). probably encodes a dihydropyridine-insensitive current. vital for survival to adulthood.
24939	
24940	
24941	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
24942	
24943	
24944	
24945	stratified squamous epithelial basement membrane protein that form anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ecm) proteins such as type iv collagen.
24946	
24947	
24948	
24949	required for protein transport from the er to the golgi complex.
24950	
24951	
24952	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
24953	
24954	dual-specificity phosphatase. preferentially dephosphorylates proteins modified by proline-directed kinases.
24955	
24956	
24957	
24958	
24959	
24960	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. displays high levels of activity on medium- and long chain acyl coas.
24961	the glycine cleavage system catalyzes the degradation of glycine. the h protein shuttles the methylamine group of glycine from the p protein to the t protein (by similarity).
24962	transcriptional activator (by similarity). binds a gc box motif. could play a role in b-cell growth and development.
24963	
24964	activates the jun n-terminal pathway through activation of the map kinase kinase map2k7. acts synergistically with prdx3 to regulate the activation of nf-kappa-b in the cytosol. this activation is kinase-dependent and involves activating the ikk complex, the ikbkb-containing complex that phosphorylates inhibitors of nf-kappa-b.
24965	
24966	
24967	
24968	
24969	
24970	
24971	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. may play an important physiological function in brain. may play a regulatory role by modulating the cellular levels of fatty acyl- coa ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. has broad specificity, active towards fatty acyl-coas with chain-lengths of c8-c18.
24972	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. may play an important physiological function in brain. may play a regulatory role by modulating the cellular levels of fatty acyl- coa ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. has broad specificity, active towards fatty acyl-coas with chain-lengths of c8-c18.
24973	
24974	
24975	
24976	
24977	
24978	
24979	
24980	
24981	protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation.
24982	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb (by similarity).
24983	
24984	
24985	
24986	
24987	
24988	
24989	
24990	muscle contraction.
24991	
24992	
24993	
24994	broad specificity aminopeptidase. plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. may play a critical role in the pathogenesis of cholesterol gallstone disease. may be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the cns. found to cleave antigen peptides bound to major histocompatibility complex class ii molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. is also implicated as a regulator of il-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. also serves as a receptor for human coronavirus serogroup 1 (hcov-229e) in a species-specific manner. mediates as well human cytomegalovirus (hcmv) infection.
24995	
24996	
24997	
24998	thought to stabilize the calcium channel in an inactivated (closed) state (by similarity).
24999	catalyzes the cleavage of l-kynurenine (l-kyn) and l-3- hydroxykynurenine (l-3ohkyn) into anthranilic (aa) and 3- hydroxyanthranilic acids (3-ohaa), respectively. has a preference for the l-3-hydroxy form. also has cysteine-conjugate-beta-lyase activity (by similarity).
25000	
25001	
25002	
25003	
25004	
25005	
25006	
25007	
25008	
25009	
25010	binds to cntf. the alpha chain provides the receptor specificity.
25011	plays a role in cytoplasmic trafficking of rna. binds to the cis-acting response element, a2re.
25012	plays a role in cytoplasmic trafficking of rna. binds to the cis-acting response element, a2re.
25013	
25014	
25015	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
25016	
25017	
25018	
25019	
25020	
25021	
25022	
25023	
25024	
25025	receptor for sema4d. plays a role in rhoa activation and subsequent changes of the actin cytoskeleton. plays a role in axon guidance, invasive growth and cell migration.
25026	participates in the folding of proteins containing disulfide bonds (by similarity).
25027	transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
25028	
25029	
25030	involved in t-cell adhesion processes. it is involved in spontaneous rosette formation with erythrocytes.
25031	
25032	
25033	ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. covalent attachment to its substrates requires prior activation by the e1 complex ube1c- appbp1 and linkage to the e2 enzyme ube2m. attachment of nedd8 to cullins activates their associated e3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
25034	
25035	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
25036	
25037	
25038	
25039	may play some role in mitochondrial processes.
25040	transcriptionally controlled transcription factor. binds to dna sites required for the transcription of alpha 1- antitrypsin, apolipoprotein ciii, transthyretin genes and hnf1- alpha. may be essential for development of the liver, kidney and intestine.
25041	
25042	
25043	
25044	
25045	
25046	
25047	
25048	
25049	binds unprenylated rab proteins, presents it to the catalytic rab ggtase dimer, and remains bound to it after the geranylgeranyl transfer reaction. the component a is thought to be regenerated by transferring its prenylated rab back to the donor membrane. less effective than rep-1 in supporting prenylation of rab3 family.
25050	
25051	phosphorylates ptdins, ptdins4p and ptdins(4,5)p2 with a preference for ptdins(4,5)p2.
25052	
25053	
25054	may be involved in transcriptional regulation.
25055	
25056	
25057	
25058	in contrast with other forms of fmo it does not seem to be a drug-metabolizing enzyme.
25059	
25060	
25061	
25062	
25063	motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport (by similarity).
25064	
25065	
25066	
25067	
25068	responsible for the biosynthesis of pyroglutamyl peptides. has a bias against acidic and tryptophan residues adjacent to the n-terminal glutaminyl residue and a lack of importance of chain length after the second residue.
25069	
25070	
25071	
25072	
25073	
25074	
25075	
25076	
25077	may function as a testis specific transcription factor. binds dna in conjunction with gtf2a2 and tbp (the tata-binding protein) and together with gtf2a2, allows mrna transcription.
25078	
25079	
25080	
25081	
25082	may be involved in the regulation of dopamine release and transport. soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). induces fibrillization of microtubule- associated protein tau. reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation.
25083	
25084	
25085	contactins mediate cell surface interactions during nervous system development. has some neurite outgrowth-promoting activity (by similarity).
25086	
25087	transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. binds to pe response elements (pere) present in the promoter of genes such as anf/nppa and acts as a direct transcriptional activator of nppa. also acts as a cofactor with gata4, a key cardiac regulator.
25088	
25089	
25090	
25091	
25092	
25093	acts as a microtubule-associated protein which interacts with cytoplasmic microtubules through beta-tubulin.
25094	
25095	
25096	may play a role in binding dynein to membranous organelles or chromosomes. may associate with the heavy chains in the dynein head where they might regulate enzyme activity (by similarity).
25097	
25098	
25099	
25100	receptor for neuropeptide y and peptide yy.
25101	the substrate transported is not yet known. induces mitochondrial depolarization.
25102	
25103	inactivation of prostaglandins.
25104	
25105	
25106	
25107	receptor for vegf or vegfc. has a tyrosine-protein kinase activity. the vegf-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.
25108	
25109	
25110	attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to na-k atpase, to the lymphocyte membrane protein gp85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. in skeletal muscle, isoform mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
25111	
25112	
25113	isoform 2 up-regulates the production of ghbp and acts as a negative inhibitor of gh signaling.
25114	
25115	prevents motor-neuron apoptosis induced by a variety of signals.
25116	promotes the exchange of ras-bound gdp by gtp.
25117	not known.
25118	apo(a) is the main constituent of lipoprotein(a) (lp(a)). it has serine proteinase activity and is able of autoproteolysis. inhibits tissue-type plasminogen activator 1. lp(a) may be a ligand for megalin/gp 330.
25119	involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
25120	
25121	
25122	receptor for the hormone galanin. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity.
25123	prefers o-glycans to n-glycans or glycolipids as acceptor substrates. the minimal acceptor substrate is the neuac- alpha-2,3(6)-gal sequence at the nonreducing end of their carbohydrate groups (by similarity).
25124	c-terminal alpha-amidation of peptides. the reaction produces a peptidyl(2-hydroxyglycine) intermediate is unstable and dismutates to glyoxylate and the corresponding desglycine peptide amide.
25125	
25126	the electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- coa dehydrogenases, glutaryl-coa and sarcosine dehydrogenase. it transfers the electrons to the main mitochondrial respiratory chain via etf-ubiquinone oxidoreductase (etf dehydrogenase).
25127	
25128	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
25129	could be involved in the activation of both nf-kappa-b via a nf-kappa-b inhibitor kinase (ikk)-dependent mechanism and stress-activated protein kinase (sapk)/jnk.
25130	
25131	
25132	
25133	
25134	involved in pre-mrna splicing. this protein is associated with snrnp u2. it binds stem loop iv of u2 snrna only in presence of the u2a@#$%& protein.
25135	
25136	
25137	involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. acts in assocation with dock1 and crk. was initially proposed to be required in complex with dock1 to activate rac rho small gtpases. may enhance the guanine nucleotide exchange factor (gef) activity of dock1.
25138	
25139	part of a complex implicated in the control of actin polymerization in cells (by similarity).
25140	
25141	
25142	component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnrnp). hnrnp play an important role in processing of precursor mrna in the nucleus.
25143	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
25144	
25145	
25146	
25147	part of pre- and post-splicing multiprotein mrnp complexes. enhances the formation of the atp-dependent a complex of the spliceosome. involved in both constitutive splicing and, in association with srp54 and sfrs10, in distinctive modulation of alternative splicing in a substrate-dependent manner. participates in mrna 3@#$%&end cleavage. involved in rent2-dependent nonsense- mediated decay (nmd) of mrnas containing premature stop codons. also mediates increase of mrna abundance and translational efficiency. binds spliced mrna 20-25 nt upstream of exon-exon junctions.
25148	
25149	
25150	inhibitor of protein-phosphatase 1.
25151	
25152	
25153	component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level.
25154	
25155	involved in the control of dna replication.
25156	may play a role in cell-cycle regulation during the transition from gamete to embryo (by similarity).
25157	
25158	
25159	
25160	
25161	may be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.
25162	
25163	
25164	
25165	
25166	
25167	
25168	
25169	
25170	
25171	
25172	calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis (by similarity).
25173	
25174	
25175	endonuclease that cleaves the 5@#$%& overhanging flap structure that is generated by displacement synthesis when dna polymerase encounters the 5@#$%& end of a downstream okazaki fragment. also possesses 5@#$%& to 3@#$%& exonuclease activity on niked or gapped double-stranded dna, and exhibits rnase h activity.
25176	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
25177	
25178	
25179	
25180	
25181	
25182	
25183	
25184	
25185	this magnesium-dependent enzyme catalyzes the hydrolysis of atp coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. isoform serca2a is involved in the regulation of the contraction/relaxation cycle.
25186	
25187	
25188	
25189	
25190	protein kinase that act on both serine and threonine residues.
25191	
25192	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
25193	
25194	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
25195	
25196	
25197	
25198	stratified squamous epithelial basement membrane protein that form anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ecm) proteins such as type iv collagen.
25199	
25200	
25201	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
25202	recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (by similarity).
25203	stimulates a migratory response in cd4+ lymphocytes, monocytes, and eosinophils. also induces t-lymphocyte expression of interleukin 2 receptor. ligand for cd4.
25204	catalyzes the n-oxidation of certain primary alkylamines to their oximes via an n-hydroxylamine intermediate. inactive toward certain tertiary amines, such as imipramine or chloropromazine. can catalyze the s-oxidation of methimazole. the truncated form is catalytically inactive.
25205	
25206	
25207	involved in regulation of mammalian cell growth.
25208	
25209	
25210	
25211	
25212	
25213	
25214	
25215	
25216	
25217	
25218	
25219	
25220	
25221	
25222	
25223	
25224	
25225	collagen type ii is specific for cartilaginous tissues. it is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
25226	
25227	
25228	
25229	
25230	
25231	
25232	exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper b into subunit i (by similarity).
25233	binds to the basic helix-loop-helix protein tal-1. this interaction seems to be critical for the regulation of red blood cell development.
25234	
25235	
25236	
25237	may function as a housekeeping dna-binding protein that regulates the expression of specific genes. has been shown to bind to the promoters of adenovirus major late protein and cyclin d1 and activate transcription. also has potent growth arrest activity, probably through inhibition of cell cycle progression. required for early embryonic development during gastrulation.
25238	
25239	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
25240	
25241	
25242	
25243	
25244	could function as a cell-adhesion protein. acts as a tumor suppressor. required for correct morphogenesis.
25245	
25246	
25247	
25248	
25249	
25250	
25251	
25252	
25253	inhibits signal transduction by increasing the gtpase activity of g protein alpha subunits thereby driving them into their inactive gdp-bound form.
25254	
25255	
25256	major airway glycoprotein.
25257	protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. this protein is also a carboxypeptidase and can deamidate tachykinins.
25258	protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. this protein is also a carboxypeptidase and can deamidate tachykinins.
25259	involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors.
25260	involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors.
25261	
25262	
25263	
25264	
25265	binds to gt and gc boxes promoters elements. probable transcriptional activator.
25266	
25267	
25268	involved in the transport of glutamate across the inner mitochondrial membrane. glutamate is cotransported with h(+).
25269	
25270	
25271	
25272	promotes guanine-nucleotide exchange on arf1 and arf5. promotes the activation of arf through replacement of gdp with gtp.
25273	
25274	inhibits the wnt/wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation by competing with tcf/lef transcription factors. has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/pkd2 and possibly of other intracellular proteins.
25275	
25276	
25277	
25278	
25279	
25280	
25281	
25282	endonuclease that specifically degrades the rna of rna- dna hybrids.
25283	required for learning most likely through its role in synaptic plasticity following nmda receptor signaling.
25284	
25285	
25286	
25287	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
25288	
25289	
25290	
25291	orphan receptor.
25292	orphan receptor.
25293	
25294	
25295	may play a role in cell differentiation in the intestinal epithelium.
25296	
25297	
25298	histone demethylase that specifically demethylates lys-4 of histone h3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. acts by oxidizing the substrate by fad to generate the corresponding imine that is subsequently hydrolyzed. demethylates both mono- and tri-methylted lys-4 of histone h3. may play a role in the repression of neuronal genes. alone, it is unable to demethylate h3 lys-4 on nucleosomes and requires the presence of rcor1/corest to achieve such activity. may also demethylate lys-9 of histone h3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.
25299	
25300	
25301	
25302	
25303	
25304	
25305	
25306	the function of subunit 3 is not clear.
25307	
25308	may bind rna.
25309	
25310	
25311	
25312	transcription factor.
25313	
25314	
25315	
25316	
25317	catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in rab proteins with an -xxcc, -xcxc and -ccxx c-terminal, such as rab1a, rab3a and rab5a respectively.
25318	
25319	involved in oxygen transport from the lung to the various peripheral tissues.
25320	
25321	
25322	
25323	plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity.
25324	
25325	
25326	type i collagen is a member of group i collagen (fibrillar forming collagen).
25327	
25328	
25329	
25330	
25331	
25332	on ligand binding, forms a receptor complex consisting of two type ii and two type i transmembrane serine/threonine kinases. type ii receptors phosphorylate and activate type i receptors which autophosphorylate, then bind and activate smad transcriptional regulators. binds to bmp-7, bmp-2 and, less efficiently, bmp-4. binding is weak but enhanced by the presence of type i receptors for bmps.
25333	
25334	
25335	
25336	
25337	cysteine protease. may have an important role in corneal physiology.
25338	
25339	
25340	function in general translation initiation by promoting the binding of the formylmethionine-trna to ribosomes. seems to function along with eif-2.
25341	
25342	
25343	
25344	
25345	nucleolin is the major nucleolar protein of growing eukaryotic cells. it is found associated with intranucleolar chromatin and preribosomal particles. it induces chromatin decondensation by binding to histone h1. it is thought to play a role in pre-rrna transcription and ribosome assembly.
25346	
25347	
25348	
25349	
25350	
25351	
25352	
25353	
25354	
25355	
25356	
25357	
25358	
25359	
25360	
25361	
25362	
25363	
25364	
25365	
25366	
25367	
25368	
25369	
25370	
25371	
25372	
25373	
25374	
25375	
25376	essental for release from glucose repression. it interacts and has functional relationship to the regulatory protein snf4. interacts also with sip1, sip2 and gal83. could phosphorylates cat8.
25377	
25378	
25379	
25380	
25381	
25382	
25383	
25384	
25385	
25386	lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. lamin a and c are present in equal amounts in the lamina of mammals.
25387	
25388	
25389	
25390	integrin alpha-v/beta-8 is a receptor for fibronectin.
25391	
25392	
25393	
25394	
25395	
25396	
25397	
25398	
25399	
25400	probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. is not an essential protein. involved in substrate recognition in ubiquitin-dependent degradation.
25401	
25402	
25403	
25404	
25405	
25406	
25407	component of a protein kinase signal transduction cascade. phosphorylates and activates map2k4 and map2k6, which in turn activate the jnk and p38 map kinases, respectively. overexpression induces apoptotic cell death.
25408	
25409	
25410	
25411	
25412	
25413	
25414	
25415	
25416	
25417	
25418	
25419	
25420	
25421	
25422	microtubule-associated force-producing protein that participates mitochondrial fission. fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. functions antagonistically with fzo1.
25423	
25424	
25425	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (by similarity).
25426	
25427	
25428	
25429	
25430	
25431	this protein promotes the gtp-dependent binding of aminoacyl-trna to the a-site of ribosomes during protein biosynthesis.
25432	
25433	
25434	
25435	
25436	
25437	high specificity for fatty acids. highest affinity for c18 chain length. decreasing the chain length or introducing double bonds reduces the affinity. may be involved in keratinocyte differentiation.
25438	
25439	
25440	
25441	
25442	
25443	
25444	
25445	
25446	
25447	
25448	
25449	downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small gtpases to the actin cytoskeleton.
25450	
25451	
25452	
25453	
25454	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
25455	may be involved in transcriptional regulation.
25456	
25457	transcription factor that binds to and transactivates the tshb promoter. binds to a minimal dna-binding sequence 5@#$%&- [tc][ag][ag]tta[tc][ag]-3@#$%&.
25458	component of a protein kinase signal transduction cascade. activates the erk and jnk kinase pathways by phosphorylation of map2k1 and map2k4. activates chuk and ikbkb, the central protein kinases of the nf-kappa-b pathway.
25459	the l3 protein is a component of the large subunit of cytoplasmic ribosomes.
25460	the l3 protein is a component of the large subunit of cytoplasmic ribosomes.
25461	
25462	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
25463	
25464	may be involved in neurite outgrowth.
25465	part of pre- and post-splicing multiprotein mrnp complexes. enhances the formation of the atp-dependent a complex of the spliceosome. involved in both constitutive splicing and, in association with srp54 and sfrs10, in distinctive modulation of alternative splicing in a substrate-dependent manner. participates in mrna 3@#$%&end cleavage. involved in rent2-dependent nonsense- mediated decay (nmd) of mrnas containing premature stop codons. also mediates increase of mrna abundance and translational efficiency. binds spliced mrna 20-25 nt upstream of exon-exon junctions.
25466	
25467	
25468	
25469	
25470	
25471	
25472	
25473	may play a role in nucleosome assembly by neutralizing basic proteins such as a and b core hnrnps (by similarity).
25474	promotes the exchange of cdc42-bound gdp by gtp. controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. cdc24 may be involved in the initial selection and organization of the budding site.
25475	
25476	
25477	
25478	
25479	
25480	
25481	blocks the elongation and depolymerization of the actin filaments at the pointed end. the tmod/tm complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (by similarity).
25482	tumor suppressor. promotes rapid degradation of ctnnb1 and participates in wnt signaling. apc activity is correlated with its phosphorylation state (by similarity).
25483	
25484	
25485	
25486	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
25487	regulation of gene expression during embryonic mesoderm formation. putative role as transcription factor.
25488	controls sodium and chloride ion transport by inhibiting the activity of wnk4, potentially by either phosphorylating the kinase or via an interaction between wnk4 and the autoinhibitory domain of wnk1. wnk4 regulates the activity of the thiazide- sensitive na-cl cotransporter, slc12a3, by phosphorylation. wnk1 may also play a role in actin cytoskeletal reorganization.
25489	
25490	
25491	
25492	
25493	may have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
25494	drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively. binds f-actin.
25495	
25496	
25497	thought to stabilize the calcium channel in an inactivated (closed) state.
25498	
25499	may play a role in encephalic photoreception.
25500	
25501	
25502	
25503	
25504	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
25505	
25506	
25507	
25508	
25509	putative receptor involved in the development of neural and epithelial tissues.
25510	
25511	
25512	
25513	binds the sequence 5@#$%&-atcaatcaa-3@#$%&. acts as a transcriptional activator of pf4 in complex with meis1. converted into a potent transcriptional activator by the (1;19) translocation. may have a role in steroidogenesis and, subsequently, sexual development and differentiation.
25514	
25515	
25516	
25517	
25518	receptor for slit1 and slit2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. in axon growth cones, the silencing of the attractive effect of ntn1 by slit2 may require the formation of a robo1-dcc complex. may be required for lung development.
25519	
25520	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
25521	
25522	implicated in the control of cell proliferation and cellular aging. may also act as a chaperone.
25523	
25524	acts as a coactivator in the regulation of translation initiation of poly(a)-containing mrnas. its stimulatory activity on translation is mediated via its action on pabpc1. competes with paip2 for binding to pabpc1. its association with eif4a and pabpc1 may potentiate contacts between mrna termini. may also be involved in translationally coupled mrna turnover. implicated with other rna-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding-region determinant of instability (mcrd) domain.
25525	
25526	
25527	
25528	
25529	
25530	not known. binds to rna homopolymers, with a preference for poly(g) and poly(u) and little for poly(a).
25531	participates in the folding of proteins containing disulfide bonds (by similarity).
25532	
25533	
25534	
25535	
25536	
25537	
25538	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to the dna sequence 5@#$%&-aa[at]ttttattac-3@#$%&.
25539	
25540	
25541	
25542	
25543	
25544	
25545	
25546	
25547	
25548	
25549	cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an l-selectin- independent fashion. has a monoamine oxidase activity (by similarity).
25550	
25551	
25552	
25553	
25554	assembly protein recruiting clathrin and adaptor protein complex 2 (ap2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. involved in ap2-dependent clathrin-mediated endocytosis at the neuromuscular junction.
25555	
25556	
25557	
25558	receptor for il10 and il22. serves as an accessory chain essential for the active il10 receptor complex and to initiate il10-induced signal transduction events.
25559	
25560	
25561	
25562	
25563	
25564	
25565	
25566	could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
25567	mediates endoplasmic reticulum to golgi transport (by similarity).
25568	mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. the receptor recognizes terminal galactose and n-acetylgalactosamine units. after ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. the receptor then returns to the cell membrane surface.
25569	
25570	
25571	transcription factor that appears to be required for the t-cell-receptor-mediated trans activation of hiv-2 gene expression. binds specifically to two purine-rich motifs in the hiv-2 enhancer. transcriptionally activates the lyn and mouse blk promoters.
25572	
25573	
25574	
25575	
25576	
25577	
25578	
25579	
25580	
25581	receptor for glucocorticoids (gc). has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (gre) and as a modulator of other transcription factors. affects inflammatory responses, cellular proliferation and differentiation in target tissues. could act as a coactivator for stat5-dependent transcription upon growth hormone (gh) stimulation and could reveal an essential role of hepatic gr in the control of body growth.
25582	
25583	essential for the import of protein precursors into the mitochondria (by similarity).
25584	
25585	
25586	functions as histone acetyltransferase and regulates transcription via chromatin remodeling. acetylates all four core histones in nucleosomes. histone acetylation gives an epigenetic tag for transcriptional activation. binds to and may be involved in the transforming capacity of the adenovirus e1a protein. mediates camp-gene regulation by binding specifically to phosphorylated creb protein.
25587	
25588	
25589	
25590	may be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (by similarity).
25591	
25592	
25593	
25594	required for protein transport from the er to the golgi complex.
25595	multifunctional protein that control proliferation, differentiation, and other functions in many cell types. many cells synthesize tgfb1 and essentially all of them have specific receptors for this protein. it regulates the actions of many other growth factors and determines a positive or negative direction of their effects. it plays an important role in bone remodelling. it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
25596	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
25597	component of heterochromatin. recognizes and binds histone h3 tails methylated at lys-9, leading to epigenetic repression. can interact with lamin b receptor (lbr). this interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. involved in the formation of functional kinetochore through interaction with mis12 complex proteins.
25598	
25599	cell autonomous negative regulator of lin-12/notch- mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. may function as part of an e3 complex to target the intracellular domains of lin-12/notch proteins for ubiquitin-dependent degradation.
25600	
25601	
25602	
25603	
25604	
25605	
25606	may act as an helicase that plays a role in rna metabolism in multiple tissues and organs within the developing embryo.
25607	
25608	
25609	
25610	
25611	
25612	
25613	
25614	
25615	plays a major role in tight junction-specific obliteration of the intercellular space (by similarity).
25616	
25617	
25618	general activator of rna polymerase iii transcription.
25619	platelet factor 4, noncovalently bound to a proteoglycan molecule, is released during platelet aggregation. pf4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. chemotactic for neutrophils and monocytes.
25620	
25621	part of the signal peptidase complex (spc), exact function is not known.
25622	
25623	
25624	
25625	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
25626	
25627	
25628	this protein is a component of ribonucleosomes.
25629	
25630	exchange factor for gtp-binding proteins rhoa, rhog and, to a lesser extent, rac1. binds physically to the nucleotide-free states of those gtpases.
25631	
25632	catalyzes the posttranslational addition of a tyrosine to the c-terminal end of detyrosinated alpha-tubulin.
25633	
25634	
25635	drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. may also be linked to the malignant phenotype.
25636	
25637	
25638	
25639	
25640	
25641	
25642	
25643	binds and transactivates the sequence 5@#$%&-taatc[ca]-3@#$%& which is found upstream of several photoreceptor-specific genes, including the opsin genes. essential for the maintenance of mammalian photoreceptors.
25644	
25645	
25646	
25647	
25648	
25649	catalyzes the nadph-dependent reduction of a variety of aldehydes to their corresponding alcohols (by similarity).
25650	catalyzes the nadph-dependent reduction of a variety of aldehydes to their corresponding alcohols (by similarity).
25651	
25652	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
25653	
25654	
25655	
25656	
25657	
25658	
25659	
25660	
25661	
25662	
25663	
25664	involved in vesicular protein trafficking.
25665	
25666	
25667	may have a role in processing of pre-rrna or in the assembly of rrna into ribosomal subunits.
25668	binds preferentially single-stranded dna and unwinds double stranded dna.
25669	differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
25670	modulates the activation of caspases during apoptosis. is a substrate for orgyia pseudotsugata multicapsid polyhedrosis virus (opmnpv) iap-mediated ubiquitination.
25671	arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
25672	
25673	
25674	
25675	
25676	
25677	
25678	
25679	
25680	
25681	seems to act exclusively upon threonine residues (by similarity).
25682	
25683	
25684	
25685	
25686	
25687	participates in wnt signaling (by similarity). plays a complex role in regulating the basal catalytic activity of the alpha subunit.
25688	
25689	
25690	
25691	
25692	recognizes and binds the palindromic sequence 5@#$%&- ttggcnnnnngccaa-3@#$%& present in viral and cellular promoters and in the origin of replication of adenovirus type 2. these proteins are individually capable of activating transcription and replication.
25693	may play a role in growth regulation and in negative regulation of cell cycle progesssion.
25694	
25695	
25696	
25697	associates with the cytoplasmic domain of a variety of cadherins. the association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. may play a crucial role in cell differentiation.
25698	
25699	vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (by similarity).
25700	converts sphingomyelin to ceramide. asm also has phospholipase c activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.
25701	
25702	
25703	cerebellin exerts neuromodulatory functions. directly stimulates norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.
25704	
25705	
25706	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator.
25707	responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-coa carboxylase. it also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-coa reductase. appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular atp levels are depleted and when 5@#$%&-amp rises in response to fuel limitation and/or hypoxia. this is a catalytic subunit (by similarity).
25708	
25709	
25710	
25711	
25712	
25713	
25714	
25715	
25716	
25717	
25718	
25719	
25720	
25721	
25722	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
25723	
25724	
25725	
25726	defensins 1/2 have antibiotic, fungicide and antiviral activities.
25727	
25728	
25729	
25730	
25731	
25732	
25733	
25734	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain (by similarity).
25735	
25736	
25737	
25738	
25739	
25740	
25741	
25742	
25743	
25744	
25745	transcriptional activator that binds the sequence 5@#$%&- atcaatcaa-3@#$%&. activates transcription of pf4 in complex with meis1.
25746	component of ribonuclease p, a protein complex that generates mature trna molecules by cleaving their 5@#$%&ends.
25747	
25748	
25749	
25750	
25751	
25752	proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. may constitute a major route for the absorption of protein digestion end-products.
25753	
25754	
25755	
25756	may be involved in several stages of intracellular trafficking (by similarity).
25757	may be involved in several stages of intracellular trafficking (by similarity).
25758	
25759	
25760	
25761	
25762	transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
25763	
25764	
25765	
25766	
25767	
25768	involved in g1 arrest. may mediate tgf beta-induced g1 arrest. binds to and inhibits complexes formed by cyclin e-cdk2, cyclin a-cdk2, and cyclin d1-cdk4. interaction with nucleoporin nup50 is required for nuclear import and for degradation of phosphorylated p27kip1 after nuclear import (by similarity).
25769	
25770	facilitative glucose transporter. probably a neuronal glucose transporter.
25771	
25772	may be involved in cytokinesis, motility, and signal transduction (by similarity).
25773	
25774	part of a multiprotein post-splicing mrnp complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. binds spliced mrna upstream of exon-exon junctions.
25775	
25776	not yet known, orphan transporter.
25777	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
25778	
25779	gtp-binding protein with gtpase activity. elicits the formation of f-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (by similarity).
25780	
25781	component of the cleavage and polyadenylation specificity factor (cpsf) complex that play a key role in pre-mrna 3@#$%&-end formation, recognizing the aauaaa signal sequence and interacting with poly(a) polymerase and other factors to bring about cleavage and poly(a) addition.
25782	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release. inhibits both auto-ubiquitination of park2 and ubiquitination of target proteins by park2 (by similarity).
25783	seems to specifically activate progelatinase a. may thus trigger invasion by tumor cells by activating progelatinase a on the tumor cell surface.
25784	
25785	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
25786	
25787	
25788	
25789	
25790	6-o-sulfation enzyme which catalyzes the transfer of sulfate from 3@#$%&-phosphoadenosine 5@#$%&-phosphosulfate (paps) to position 6 of the n-sulfoglucosamine residue (glcns) of heparan sulfate.
25791	
25792	protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. they compact sperm dna into a highly condensed, stable and inactive complex.
25793	
25794	
25795	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
25796	
25797	specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
25798	
25799	
25800	
25801	molecular chaperone. has atpase activity (by similarity).
25802	
25803	
25804	implicated in neuroendocrine secretory processes. may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. seems to lack intrinsic enzyme activity. may play a role in the regulation of secretory granules via its interaction with sntb2.
25805	histone h3, along with histone h4, plays a central role in nucleosome formation.
25806	
25807	
25808	may play a role in promoting maturation and morphological differentiation of cerebellar neurons.
25809	
25810	
25811	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
25812	
25813	binds to actin and plays an important role in the assembly of the z-disk.
25814	
25815	
25816	
25817	
25818	
25819	
25820	associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. it may function in the assembly and/or transport of ribosome.
25821	
25822	the gpib-v-ix complex functions as the von willebrand factor receptor and mediates von willebrand factor-dependent platelet adhesion to blood vessels. the adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis (by similarity).
25823	
25824	
25825	may play a role in a erbb3-regulated signal transduction pathway. seems be involved in growth regulation. acts a corepressor of the androgen receptor (ar) and is regulated by the erbb3 ligand neuregulin-1/heregulin (hrg). inhibits transcription of some e2f1-regulated promoters, probably by recruiting histone acetylase (hat) activity. binds rna. associates with 28s, 18s and 5.8s mature rrnas, several rrna precursors and probably u3 small nucleolar rna. may be involved in regulation of intermediate and late steps of rrna processing. may be involved in ribosome assembly (by similarity). mediates cap-independent translation of specific viral iress (internal ribosomal entry site). together with ptbp1 is required for the translation initiation on the foot- and-mouth disease virus (fmdv) ires.
25826	
25827	
25828	
25829	
25830	acts on epoxides (alkene oxides, oxiranes) and arene oxides. plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. also determines steady-state levels of physiological mediators. has phosphatase activity (by similarity).
25831	probably involved in membrane protein trafficking (by similarity).
25832	
25833	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
25834	
25835	participates in the bidirectional intercellular signaling between the posterior follicle cells and oocyte to establish spatial coordinates that induces axis formation. complex with tsu is essential for cytoplasmic localization of oskar in the posterior pole of oocytes. required for the polarization of the oocyte microtubule cytoskeleton.
25836	acts as a negative coregulator for lim homeodomain transcription factors. via the recruitment of the sin3a/histone deacetylase corepressor complex.
25837	
25838	
25839	
25840	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. binds to sites in the 5@#$%&-flanking sequence of its coding region with various affinities. the consensus sequences of the high and low affinity binding sites are 5@#$%&-taatga[cg]-3@#$%& and 5@#$%&-ctaatttt- 3@#$%&.
25841	
25842	may play a role in spermatogenesis.
25843	
25844	may play a role in spermatogenesis.
25845	
25846	
25847	
25848	
25849	
25850	ph-dependent, voltage-insensitive, background potassium channel protein. rectification direction results from potassium ion concentration on either side of the membrane. acts as an outward rectifier when external potassium concentration is low. when external potassium concentration is high, current is inward.
25851	
25852	
25853	phosphorylates and activates not only pkb/akt, but also pka, pkc-zeta, p70s6k and p90s6k/rsk. may play a general role in signaling processes and in development (by similarity). isoform 3 is catalytically inactive.
25854	
25855	
25856	
25857	
25858	
25859	
25860	
25861	
25862	essential component of the nelf complex, a complex that negatively regulates the elongation of transcription by rna polymerase ii. the nelf complex, which acts via an association with the dsif complex and causes transcriptional pausing, is counteracted by the p-tefb kinase complex. probably required to interact with the rna polymerase ii complex.
25863	
25864	associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. it may function in the assembly and/or transport of ribosome.
25865	
25866	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
25867	
25868	
25869	
25870	
25871	
25872	
25873	
25874	
25875	
25876	
25877	
25878	
25879	
25880	
25881	receptor for the lysosphingolipid sphingosine 1- phosphate (s1p). s1p is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. when expressed in rat htc4 hepatoma cells, is capable of mediating s1p-induced cell proliferation and suppression of apoptosis.
25882	
25883	an integral component of the pericentriolar material (pcm).
25884	
25885	
25886	
25887	
25888	component of pre-mrna cleavage complex ii.
25889	may be involved in the binding and intracellular trafficking of cobalamin (vitamin b12).
25890	
25891	
25892	able to form cytoplasmic structures termed death effector filaments. enhances apaf1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. seems to bind atp.
25893	
25894	
25895	probable glucose transporter.
25896	
25897	
25898	
25899	
25900	an integral component of the pericentriolar material (pcm).
25901	
25902	
25903	
25904	
25905	
25906	
25907	
25908	
25909	receptor for glutamate. the activity of this receptor is mediated by a g-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current.
25910	
25911	this protein is associated with snrnp u1.
25912	
25913	
25914	
25915	
25916	may be involved in transcriptional regulation.
25917	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
25918	
25919	
25920	
25921	
25922	
25923	
25924	
25925	
25926	
25927	
25928	
25929	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
25930	
25931	
25932	
25933	high affinity receptor for semaphorins 3c, 3f, vegf-165 and vegf-145 isoforms of vegf, and the plgf-2 isoform of pgf.
25934	
25935	
25936	
25937	
25938	as a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. recruits pip5k1c to focal adhesion plaques and strongly activates its kinase activity (by similarity).
25939	
25940	
25941	
25942	
25943	
25944	
25945	does not possess sterol isomerase activity and does not bind sigma ligands (by similarity).
25946	
25947	
25948	
25949	
25950	
25951	
25952	
25953	binds dna. interacts with chromatin via matrix attachment regions (mars). likely to participate in nuclear architecture by connecting chromatin with the nuclear matrix and potentially with the nuclear envelope (by similarity).
25954	
25955	
25956	
25957	
25958	
25959	guanine nucleotide exchange factor for the rho family of ras-related gtpases.
25960	
25961	essential component of the nelf complex, a complex that negatively regulates the elongation of transcription by rna polymerase ii. the nelf complex, which acts via an association with the dsif complex and causes transcriptional pausing, is counteracted by the p-tefb kinase complex.
25962	
25963	
25964	this receptor binds polymeric iga and igm at the basolateral surface of epithelial cells. the complex is then transported across the cell to be secreted at the apical surface. during this process a cleavage occurs that separate the extracellular (known as the secretory component) from the transmembrane segment.
25965	
25966	
25967	
25968	
25969	
25970	appears to have dual functions such as cytoplasmic retention of attached nf-kappa-b proteins and generation of p50 by a cotranslational processing. the proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of nfkb1/p105 also appears to occur posttranslationally. p50 binds to the kappa-b consensus sequence 5@#$%&-ggrnnyycc-3@#$%&, located in the enhancer region of genes involved in immune response and acute phase reactions. plays a role in the regulation of apoptosis.
25971	
25972	
25973	
25974	
25975	
25976	
25977	
25978	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
25979	
25980	
25981	
25982	
25983	
25984	
25985	
25986	
25987	
25988	
25989	
25990	
25991	implicated in development of nervous system and pancreatic endocrine cells.
25992	
25993	
25994	
25995	
25996	multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
25997	endonuclease that cleaves the 5@#$%& overhanging flap structure that is generated by displacement synthesis when dna polymerase encounters the 5@#$%& end of a downstream okazaki fragment. also possesses 5@#$%& to 3@#$%& exonuclease activity on niked or gapped double-stranded dna, and exhibits rnase h activity.
25998	
25999	
26000	tumor suppressor probably involved in transcriptional and posttranscriptional control pathways. may be involved in cell cycle progression through the regulation of cyclin d1/prad1 expression.
26001	necessary for protein translocation in the endoplasmic reticulum.
26002	may be involved in transcriptional regulation.
26003	
26004	essential component of the nelf complex, a complex that negatively regulates the elongation of transcription by rna polymerase ii. the nelf complex, which acts via an association with the dsif complex and causes transcriptional pausing, is counteracted by the p-tefb kinase complex.
26005	
26006	
26007	
26008	
26009	probably involved in nervous system development and function.
26010	
26011	
26012	
26013	
26014	probably involved in egf and insulin receptor signaling.
26015	
26016	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
26017	
26018	
26019	
26020	induces cartilage and bone formation. may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. plays a role in calcium regulation and bone homeostasis (by similarity).
26021	
26022	protein transport. probably involved with ras-related protein rab-3a in synaptic vesicle traffic and/or synaptic vesicle fusion. could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
26023	
26024	nad-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.
26025	
26026	rab4/rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. required for endosome fusion either homotypically or with clathrin coated vesicles. plays a role in the lysosomal trafficking of cathepsin d from the golgi to lysosomes. also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (ptdinsp3).
26027	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
26028	
26029	
26030	
26031	
26032	
26033	
26034	
26035	
26036	
26037	
26038	
26039	
26040	
26041	
26042	
26043	essential bifunctional enzyme that catalyzes both the n- deacetylation and the n-sulfation of glucosamine (glcnac) of the glycosaminoglycan in heparan sulfate. modifies the glcnac-glca dissacharide repeating sugar backbone to make n-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. plays a role in determining the extent and pattern of sulfation of heparan sulfate.
26044	
26045	
26046	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
26047	
26048	
26049	prohibitin inhibits dna synthesis. it has a role in regulating proliferation. as yet it is unclear if the protein or the mrna exhibits this effect. may play a role in regulating mitochondrial respiration activity and in aging.
26050	
26051	receptor for atrial natriuretic peptide (anp), brain natriuretic peptide (bnp), and c-type natriuretic peptide (cnp). has guanylate cyclase activity on binding of ligand. the activation order seems to be cnp > bnp > anp.
26052	
26053	
26054	
26055	
26056	
26057	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
26058	
26059	involved in cytokinesis (potential).
26060	
26061	activates the jun n-terminal pathway through activation of the map kinase kinase map2k7. acts synergistically with prdx3 to regulate the activation of nf-kappa-b in the cytosol. this activation is kinase-dependent and involves activating the ikk complex, the ikbkb-containing complex that phosphorylates inhibitors of nf-kappa-b.
26062	fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, dna, and actin. fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. interaction with tnr mediates inhibition of cell adhesion and neurite outgrowth (by similarity).
26063	
26064	
26065	thrombin, which cleaves bonds after arg and lys, converts fibrinogen to fibrin and activates factors v, vii, viii, xiii, and, in complex with thrombomodulin, protein c.
26066	
26067	
26068	
26069	
26070	
26071	
26072	
26073	
26074	
26075	
26076	
26077	can act as repulsive axon guidance cues. may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (by similarity).
26078	
26079	
26080	
26081	
26082	may be a bridge molecule between bcl2 and arhgap1/cdc42 in promoting cell death.
26083	
26084	recognizes and binds the palindromic sequence 5@#$%&- ttggcnnnnngccaa-3@#$%& present in viral and cellular promoters and in the origin of replication of adenovirus type 2. these proteins are individually capable of activating transcription and replication.
26085	
26086	mediates the voltage-dependent sodium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which na(+) ions may pass in accordance with their electrochemical gradient.
26087	
26088	
26089	
26090	
26091	
26092	could be involved in bone formation.
26093	
26094	
26095	
26096	involved in the presentation of foreign antigens to the immune system.
26097	
26098	
26099	
26100	
26101	
26102	
26103	
26104	
26105	
26106	involved in regulation of actin cytoskeleton organization and endocytosis.
26107	may be involved in transcriptional regulation.
26108	
26109	this is one of the five types (d1 to d5) of receptors for dopamine. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
26110	
26111	
26112	
26113	
26114	
26115	
26116	
26117	
26118	
26119	
26120	
26121	
26122	
26123	neutral amino acid/proton symporter. has a ph-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. besides small apolar l-amino acids, it also recognize their d-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (by similarity).
26124	
26125	
26126	
26127	
26128	
26129	
26130	
26131	
26132	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
26133	
26134	
26135	
26136	
26137	
26138	the cd3 complex mediates signal transduction.
26139	
26140	may play a role in the processes of lymphocyte homing to secondary lymphoid organs.
26141	
26142	
26143	
26144	
26145	could be involved in signal transduction.
26146	
26147	heparin binding mitogenic protein. has neurite extension activity.
26148	
26149	
26150	
26151	
26152	
26153	required for the proper development and maintenance of neurons presumably by affecting rna metabolism.
26154	
26155	
26156	
26157	
26158	
26159	polycomb group (pcg) protein. pcg proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. pcg proteins are not required to initiate repression, but to maintain it during later stages of development. they probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. component of the prc2 complex, which methylates lys-9 and lys-27 residues of histone h3.
26160	
26161	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
26162	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
26163	
26164	
26165	
26166	
26167	
26168	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
26169	
26170	collagen type ii is specific for cartilaginous tissues. it is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
26171	
26172	
26173	
26174	collagen type iii occurs in most soft connective tissues along with type i collagen.
26175	may constitute a glutathionine peroxidase-like protective system against oxidative stresses (by similarity).
26176	
26177	could be an important component in vesicular trafficking cycling between the golgi complex and the apical plasma membrane. could be involved in myelin biogenesis and/or myelin function.
26178	
26179	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
26180	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
26181	
26182	
26183	
26184	this protein promotes the gtp-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome.
26185	
26186	transcriptional regulator that probably plays an important role in lymphomagenesis.
26187	
26188	
26189	
26190	
26191	
26192	
26193	
26194	may play a role in lipid exchange and transport throughout the body. may participate in reverse cholesterol transport from peripheral cells to the liver.
26195	
26196	
26197	
26198	
26199	
26200	
26201	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1d gives rise to l-type calcium currents. long-lasting (l-type) calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group. they are blocked by dihydropyridines (dhp), phenylalkylamines, benzothiazepines, and by omega-agatoxin-iiia (omega-aga-iiia). they are however insensitive to omega-conotoxin- gvia (omega-ctx-gvia) and omega-agatoxin-iva (omega-aga-iva).
26202	
26203	
26204	mediates the binding, internalization, and catabolism of lipoprotein particles. it can serve as a ligand for the ldl (apo b/e) receptor and for the specific apo-e receptor (chylomicron remnant) of hepatic tissues.
26205	
26206	
26207	
26208	
26209	
26210	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. may be involved in the remodeling of the actin cytoskeleton. binds actin with high affinity both in the absence and presence of atp and its mechanochemical activity is inhibited by calcium ions. also acts as a gtpase activating protein on rho.
26211	
26212	may play a fundamental role in early development of cns. may regulate gene expression and development of postmitotic undifferentiated young neurons (by similarity).
26213	
26214	
26215	
26216	
26217	
26218	
26219	probable transcription factor. may play an important role in recruitment of elf4 into pml nuclear bodies.
26220	
26221	
26222	
26223	
26224	
26225	
26226	
26227	involved in peroxisomal proliferation. may regulate peroxisomes division by recruiting the dynamin-related gtpase dnm1l to the peroxisomal membrane.
26228	
26229	
26230	transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
26231	
26232	
26233	muscle contraction.
26234	
26235	
26236	
26237	
26238	divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. macrophage-specific membrane transport function. controls natural resistance to infection with intracellular parasites. pathogen resistance involves sequestration of fe(2+) and mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
26239	secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides.
26240	
26241	
26242	
26243	
26244	
26245	
26246	serine protease that shows proteolytic activity against a nonspecific substrate beta-casein. promotes or induces cell death either by direct binding to and inhibition of birc proteins (also called inhibitor of apoptosis proteins, iaps), leading to an increase in caspase activity, or by a birc inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. isoform 2 seems to be proteolytically inactive.
26247	muscle contraction.
26248	
26249	
26250	
26251	may be a regulatory subunit of cytochrome c oxidase that mediates the higher level of energy production in target cells by estrogen.
26252	together with cas it may play a role in the control of epithelial cell polarity. seems to help to recruit protein tyrosine kinase 2 beta (ptk2b) to cell matrix adhesions, thereby initiating phosphorylation of ptk2b and ptk2b-dependent signaling (by similarity).
26253	may serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. weakly activates the map kinase pathway.
26254	
26255	
26256	
26257	
26258	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation via its interaction with the myocyte enhancer factors such as mef2a, mef2c and mef2d.
26259	involved in dna excision repair. may play a part in dna damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes.
26260	
26261	essental for release from glucose repression. it interacts and has functional relationship to the regulatory protein snf4. interacts also with sip1, sip2 and gal83. could phosphorylates cat8.
26262	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
26263	integrin alpha-v/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von willebrand factor. integrin alpha-iib/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. integrins alpha-iib/beta-3 and alpha-v/beta-3 recognize the sequence r-g-d in a wide array of ligands. integrin alpha-iib/beta-3 recognizes the sequence h-h-l-g-g-g-a-k-q-a-g-d-v in fibrinogen gamma chain. following activation integrin alpha- iib/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. this step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
26264	possible adhesion molecule with a role in early hematopoiesis by mediating attachment to stromal cells. influences the survival and/or proliferation of b-cell precursors. binding to cells requires mn(2+) (by similarity).
26265	protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. attachment to proteins as a lys-48-linked polymer usually leads to their degradation by proteasome. attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and dna repair.
26266	
26267	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
26268	
26269	
26270	required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
26271	
26272	
26273	
26274	
26275	
26276	
26277	
26278	
26279	
26280	
26281	
26282	
26283	
26284	
26285	
26286	
26287	
26288	
26289	
26290	
26291	
26292	probably involved in lipid transport.
26293	
26294	
26295	
26296	
26297	
26298	
26299	may play an important role in fibrillogenesis by controlling lateral growth of collagen ii fibrils.
26300	
26301	
26302	
26303	
26304	
26305	
26306	
26307	rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. it may also have a role in the development of malignancy and the growth progression of some tumors.
26308	
26309	rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. it may also have a role in the development of malignancy and the growth progression of some tumors.
26310	
26311	
26312	
26313	
26314	aminopeptidases catalyze the hydrolysis of amino acid residues from the n-terminus of peptide or protein substrates. able to cleave angiotensin iii to generate angiotensin iv, a bioactive peptide of the renin-angiotensin pathway. not able to cleave angiotensin i and angiotensin ii. may play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.
26315	adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. mediates activation of nf-kappa-b and jnk and is involved in apoptosis. the traf1/traf2 complex recruits the apoptotic suppressors birc2 and birc3 to tnfrsf1b/tnfr2.
26316	
26317	
26318	
26319	
26320	
26321	enzyme with a broad specificity.
26322	
26323	
26324	
26325	synthesizes selenophosphate from selenide and atp.
26326	
26327	
26328	membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. binds to calmodulin.
26329	
26330	binds the camp response element (cre) (consensus: 5@#$%&- gtgacgt[ag][ag]-3@#$%&), a sequence present in many viral and cellular promoters.
26331	
26332	essential for the import of protein precursors into the mitochondria (by similarity).
26333	
26334	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
26335	major role in the synthesis of nucleoside triphosphates other than atp. the atp gamma phosphate is transferred to the ndp beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
26336	
26337	
26338	
26339	
26340	
26341	involved in the replication of mitochondrial dna.
26342	
26343	
26344	
26345	
26346	
26347	
26348	
26349	
26350	
26351	
26352	
26353	splice factor that is required for the first atp- dependent step in spliceosome assembly and for the interaction of u2 snrnp with the branchpoint. has weak rna-dependent atpase activity. required for mrna export.
26354	
26355	socs family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. cis is involved in the negative regulation of cytokines that signal through the jak-stat5 pathway such as erythropoietin, prolactin and interleukin 3 (il3) receptor. inhibits stat5 trans-activation by suppressing its tyrosine phosphorylation (by similarity).
26356	
26357	probable trna acetyltransferase required for the formation of the modified nucleoside n(4)-acetylcytidine in serine and leucine trnas. binds rna.
26358	involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
26359	binds with high affinity to rna molecules that contain au-rich elements (ares) found within the 3@#$%& untranslated regions of many protooncogenes and cytokine mrnas. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain (by similarity).
26360	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. this subunit is involved in antigen processing to generate class i binding peptides.
26361	
26362	
26363	
26364	
26365	
26366	
26367	
26368	
26369	
26370	
26371	
26372	
26373	golgi auto-antigen; probably involved in maintaining cis-golgi structure.
26374	transcription factor for tyrosinase and tyrosinase- related protein 1. binds to a symmetrical dna sequence (e-boxes) (5@#$%&-cacgtg-3@#$%&) found in the tyrosinase promoter. plays a critical role in the differentiation of various cell types as neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
26375	may be involved in transcriptional regulation.
26376	histone h3, along with histone h4, plays a central role in nucleosome formation.
26377	
26378	
26379	
26380	
26381	
26382	
26383	
26384	
26385	
26386	
26387	
26388	amine transporter. terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
26389	
26390	
26391	
26392	
26393	
26394	
26395	
26396	
26397	mediates the association of the molecular chaperones hsc70 and hsp90 (hspca and hspcb).
26398	
26399	
26400	
26401	
26402	
26403	
26404	
26405	plays a role in the insulin signaling pathway.
26406	involved in the transduction of mitogenic signals from the cell membrane to the nucleus. may play a role in the postsynaptic responses of hippocampal neuron.
26407	
26408	
26409	
26410	
26411	
26412	
26413	
26414	
26415	
26416	
26417	
26418	
26419	
26420	
26421	may control phosphatidylinositol concentration in transport vesicles from the subrhabdomeric cisternae (src) to the rhabdomere. may function as a calcium transporter.
26422	
26423	
26424	
26425	ligand for members of the frizzled family of seven transmembrane receptors. probable developmental protein. may be a signaling molecule which affects the development of discrete regions of tissues. is likely to signal over only few cell diameters (by similarity).
26426	
26427	
26428	
26429	the beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating g protein inhibition and controlling the alpha-1 subunit membrane targeting.
26430	muscle contraction.
26431	transcriptional activator that binds with high affinity to the t-cell enhancer motif 5@#$%&-aacaaag-3@#$%& motif.
26432	plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. this phosphodiesterase catalyzes the specific hydrolysis of cgmp to 5@#$%&- gmp.
26433	
26434	
26435	
26436	
26437	
26438	
26439	has broad nucleoside selectivity (uridine, ademosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes.
26440	important modulator in the hla class ii restricted antigen presentation pathway by interaction with the hla-dm molecule.
26441	
26442	
26443	
26444	potential calcium-dependent cell-adhesion protein.
26445	
26446	strong transcriptional activator; dna-binding protein that specifically recognize the sequence 5@#$%&-yaac[gt]g-3@#$%&. could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and b-lymphoid cells.
26447	the muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of g proteins. primary transducing effect is adenylate cyclase inhibition.
26448	
26449	
26450	
26451	
26452	type i collagen is a member of group i collagen (fibrillar forming collagen).
26453	
26454	
26455	core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal dna. component of several complexes which regulate chromatin metabolism. these include the chromatin assembly factor 1 (caf-1) complex, which is required for chromatin assembly following dna replication and dna repair; the core histone deacetylase (hdac) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodelling and histone deacetylase complex (the nurd complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the prc2/eed-ezh2 complex, which promotes repression of homeotic genes during development.
26456	
26457	
26458	
26459	
26460	
26461	
26462	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules (by similarity).
26463	
26464	involved in the presentation of foreign antigens to the immune system.
26465	
26466	
26467	guanine nucleotide exchange factor (gef) for rap1a, rap1b and rap2b gtpases. does not interact with camp or cgmp.
26468	
26469	
26470	
26471	may be required for neuronal cell differentiation.
26472	
26473	
26474	
26475	the enzyme cleaves lys-arg and arg-ser bonds. it activates, in a reciprocal reaction, factor xii after its binding to a negatively charged surface. it also releases bradykinin from hmw kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
26476	
26477	
26478	
26479	
26480	
26481	
26482	may play a role in cell proliferation.
26483	
26484	
26485	
26486	
26487	
26488	interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. could also bind muscle proteins such as actin to membrane complexes in muscle. may be involved not only in the crosslinking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.
26489	
26490	
26491	
26492	the 26s protease is involved in the atp-dependent degradation of ubiquitinated proteins. the regulatory (or atpase) complex confers atp dependency and substrate specificity to the 26s complex.
26493	
26494	this protein binds preferentially and cooperatively to ss-dna. probably involved in mitochondrial dna replication.
26495	
26496	cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an nadph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
26497	
26498	
26499	
26500	
26501	macrophage-specific membrane transport. important in metal transport, in particular iron.
26502	component of the anaphase promoting complex/cyclosome (apc/c), a cell cycle-regulated e3 ubiquitin-protein ligase complex that controls progression through mitosis and the g1 phase of the cell cycle. the apc/c is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating e2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26s proteasome. in early mitosis, the apc/c is activated by cdc20 and targets securin pds1, the b-type cyclin clb5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. in late mitosis and in g1, degradation of clb5 allows activation of the apc/c by cdh1, which is needed to destroy cdc20 and the b-type cyclin clb2 to allow exit from mitosis and creating the low cdk state necessary for cytokinesis and for reforming prereplicative complexes in g1 prior to another round of replication.
26503	
26504	
26505	
26506	
26507	
26508	regulates eif4e activity by preventing its assembly into the eif4f complex. mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the map kinase pathway.
26509	
26510	
26511	
26512	
26513	
26514	
26515	
26516	
26517	transcriptional factor which uses the canonical single or multiple carg boxes dna sequence. acts as a cofactor of serum response factor (srf) and has the potential to modulate srf-target genes. suppresses tnf-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. it may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (by similarity).
26518	
26519	
26520	
26521	
26522	
26523	major glycoprotein component of a variety of mucus gels. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
26524	
26525	
26526	rapidly transports ca(2+) during excitation-contraction coupling. ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
26527	
26528	produces pentose sugars for nucleic acid synthesis and main producer of nadph reducing power.
26529	
26530	
26531	
26532	
26533	
26534	
26535	
26536	
26537	
26538	the physiological function of prp is not known.
26539	
26540	
26541	
26542	
26543	
26544	
26545	
26546	isoform epor-t, missing the cytoplasmic tail, acts as a dominant-negative receptor of epor-mediated signaling.
26547	
26548	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. may govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
26549	this is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters. may be considered as a novel component of the nf-kappa-b signaling axis responsible for the survival and activation of b-cells after bcr cross-linking (by similarity).
26550	
26551	
26552	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
26553	the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-coa and co(2). it contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (e1), lipoamide acyltransferase (e2) and lipoamide dehydrogenase (e3).
26554	critical component of the membrane-bound oxidase of phagocytes that generates superoxide. it is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic nadph across the plasma membrane to molecular oxygen on the exterior. also functions as a voltage-gated proton channel that mediates the h(+) currents of resting phagocytes. it participates in the regulation of cellular ph and is blocked by zinc.
26555	
26556	seems to act exclusively upon threonine residues (by similarity).
26557	
26558	
26559	
26560	the interaction with sm proteins inhibits their assembly on u rna and interferes with snrnp biogenesis. inhibits the binding of survival motor neuron protein (smn) to sm proteins. may participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.
26561	
26562	receptor for glutamate. l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists. this receptor binds ampa(quisqualate) > glutamate > kainate.
26563	may have a functional role during normal fetal development.
26564	
26565	interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. could also bind muscle proteins such as actin to membrane complexes in muscle. may be involved not only in the crosslinking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.
26566	
26567	
26568	
26569	
26570	
26571	
26572	
26573	transcription factor which binds specifically to the mef2 element present in the regulatory regions of many muscle- specific genes. activates transcription via this element. may be involved in muscle-specific and/or growth factor-related transcription.
26574	
26575	
26576	binds the sequence 5@#$%&-atcaatcaa-3@#$%&. acts as a transcriptional activator of pf4 in complex with meis1. converted into a potent transcriptional activator by the (1;19) translocation. may have a role in steroidogenesis and, subsequently, sexual development and differentiation.
26577	
26578	
26579	
26580	
26581	
26582	
26583	
26584	
26585	
26586	
26587	
26588	
26589	may neutralize hydrolytic enzymes.
26590	
26591	
26592	putative odorant receptor.
26593	may be involved in transcriptional regulation.
26594	may act as a gtpase activating protein for rab family protein(s) (potential).
26595	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
26596	troponin t is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin atpase activity.
26597	
26598	muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin- crosslinking protein. may be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the z-disks in muscle cells.
26599	
26600	
26601	
26602	
26603	
26604	
26605	
26606	
26607	
26608	
26609	
26610	
26611	
26612	
26613	
26614	
26615	inactivates histamine by n-methylation. plays an important role in degrading histamine and in regulating the airway response to histamine.
26616	
26617	
26618	
26619	may be involved in n-glycosylation through its association with n-oligosaccharyl transferase.
26620	
26621	
26622	
26623	
26624	
26625	
26626	
26627	
26628	
26629	
26630	
26631	
26632	
26633	multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. may play an important role in development and differentiation. the function of yy1 as an activator or a repressor is specified by the presence of other proteins. for example it acts as a repressor in absence of adenovirus e1a protein but as an activator in its presence.
26634	
26635	may play a functional role in the cell filament networks.
26636	binding of freac-3 and freac-4 to their cognate sites results in bending of the dna at an angle of 80-90 degrees.
26637	
26638	
26639	
26640	
26641	
26642	
26643	
26644	
26645	
26646	
26647	may play an important role in b-cell differentiation as well as neural development and spermatogenesis. involved in the regulation of the cd19 gene, a b-lymphoid-specific target gene.
26648	
26649	
26650	
26651	might support glycosylation reactions in the golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. hydrolyzes preferentially nucleoside 5@#$%&-diphosphates, nucleoside 5@#$%&-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5@#$%&-monophosphates. the order of activity with different substrates is gdp > idp >> udp = cdp >> adp (by similarity).
26652	
26653	may play a role in regulation of differentiation. in vitro, binds rna, preferentially to both poly(g) and poly(u). overexpressed, blocks differentiation of k562 leukemia cells following treatment with phorbol esters or sodium butyrate without affecting proliferation.
26654	
26655	
26656	
26657	
26658	may be involved in transcriptional regulation.
26659	
26660	
26661	
26662	
26663	
26664	
26665	
26666	
26667	highly selective for arachidonate-containing species of diacylglycerol (dag). may terminate signals transmitted through arachidonoyl-dag or may contribute to the synthesis of phospholipids with defined fatty acid composition.
26668	
26669	
26670	
26671	
26672	
26673	thought to form a receptor-activated non-selective calcium permeant cation channel. probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or g-protein coupled receptors. seems to be also activated by intracellular calcium store depletion.
26674	
26675	
26676	
26677	cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. dynein has atpase activity; the force-producing power stroke is thought to occur on release of adp.
26678	
26679	
26680	
26681	
26682	probable helicase, which may be involved in rna maturation (by similarity).
26683	
26684	
26685	possible cell adhesion receptor. it possesses an intrinsic protein tyrosine phosphatase activity (ptpase). it controls motor axon guidance.
26686	
26687	transcriptional activator which recognizes variations of the palindromic sequence 5@#$%&-attcccnngggaatt-3@#$%& (by similarity).
26688	capable of removing ubiquitin from ubiquitinated proteins; also capable of removing nedd8 from nedd8 conjugates but has no effect on sentrin-1 conjugates.
26689	
26690	
26691	
26692	
26693	
26694	
26695	
26696	
26697	ampk is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-coa carboxylase. also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-coa reductase and hormone- sensitive lipase. this is a regulatory subunit, may be a positive regulator of ampk activity. it may also serve as an adapter molecule for the catalytic alpha-subunit.
26698	
26699	
26700	
26701	cbf binds to the core site, 5@#$%&-pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, lck, il-3 and gm-csf promoters. the alpha subunit binds dna and appears to have a role in the development of normal hematopoiesis. isoform aml-1l interferes with the transactivation activity of runx1. acts synergistically with elf4 to transactivate the il-3 promoter and with elf2 to transactivate the mouse blk promoter. inhibits myst4- dependent transcriptional activation.
26702	imdl and imds may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the calcrl/ramps receptor complexes. activates the camp-dependent pathway.
26703	
26704	
26705	involved in vesicular protein trafficking.
26706	
26707	
26708	major airway glycoprotein.
26709	
26710	
26711	
26712	
26713	seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.
26714	
26715	
26716	
26717	
26718	
26719	
26720	
26721	
26722	
26723	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
26724	
26725	
26726	
26727	participates in dna repair and in chromosomal dna replication.
26728	mrs4 suppresses a mitochondrial splice defect in the first intron of the cob gene. it may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). not essential.
26729	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling. phosphorylates dvl1.
26730	
26731	
26732	
26733	
26734	
26735	
26736	
26737	
26738	
26739	
26740	tumor suppressor. promotes rapid degradation of ctnnb1 and participates in wnt signaling. apc activity is correlated with its phosphorylation state.
26741	probable transcription regulator.
26742	
26743	could have a part in mechanisms of transcriptional regulation similar to that played by yeast hir1 and hir2 together.
26744	
26745	binds to, and destabilizes, ornithine decarboxylase which is then degraded. also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter.
26746	
26747	
26748	
26749	
26750	
26751	
26752	
26753	
26754	
26755	
26756	binds and is activated by neuregulins and ntak.
26757	the gpib-v-ix complex functions as the von willebrand factor receptor and mediates von willebrand factor-dependent platelet adhesion to blood vessels. the adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis (by similarity).
26758	
26759	
26760	
26761	
26762	binds and is activated by neuregulins and ntak.
26763	
26764	this proteoglycan is a major component of extracellular matrix of cartilagenous tissues. a major function of this protein is to resist compression in cartilage. it binds avidly to hyaluronic acid via an n-terminal globular region.
26765	regulator of protein export for nes-containing proteins. also plays a role in mrna nuclear export.
26766	
26767	
26768	
26769	this is a membrane-bound, calcium-inhibitable adenylyl cyclase.
26770	
26771	
26772	
26773	thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity. coactivates six1, and seems to coactivate six2, six4 and six5. the repression of precursor cell proliferation in myoblasts by six1 is switched to activation through recruitment of eya3 to the six1-dach1 complex and seems to be dependent on eya3 phosphatase activity (by similarity). may be involved in development of the eye.
26774	possible cell adhesion receptor. it possesses an intrinsic protein tyrosine phosphatase activity (ptpase). it controls motor axon guidance.
26775	sam (substrate-adhesion molecule) that appears to inhibit cell migration. may play a role in supporting the growth of epithelial tumors. is a ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-v/beta-3 and alpha-v/beta-6.
26776	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
26777	
26778	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules.
26779	
26780	
26781	
26782	
26783	
26784	
26785	
26786	
26787	
26788	
26789	receptor for hyaluronic acid (ha). mediates cell-cell and cell-matrix interactions through its affinity for ha, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix matalloproteinases (mmps). adhesion with ha plays an important role in cell migration, tumor growth and progression. also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. altered expression or dysfunction causes numerous pathogenic phenotypes. great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
26790	
26791	
26792	
26793	
26794	receptor for hyaluronic acid (ha). mediates cell-cell and cell-matrix interactions through its affinity for ha, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix matalloproteinases (mmps). adhesion with ha plays an important role in cell migration, tumor growth and progression. also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. altered expression or dysfunction causes numerous pathogenic phenotypes. great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
26795	
26796	
26797	
26798	
26799	
26800	
26801	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
26802	
26803	interconversion of serine and glycine.
26804	
26805	probable transcription factor, which seems to be involved in the negative regulation of cellular determination and in the differentiation of several lineages including myogenesis, osteogenesis, and neurogenesis. inhibits myogenesis by sequestrating e proteins, inhibiting trans-activation by mef2, and inhibiting dna-binding by myod1 through physical interaction. this interaction probably involves the basic domains of both proteins (by similarity). also represses expression of proinflammatory cytokines such as tnfa and il1b.
26806	
26807	
26808	
26809	renin is a highly specific endopeptidase, whose only known function is to generate angiotensin i from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
26810	
26811	
26812	
26813	
26814	
26815	binds to the sequence element 5@#$%&-aacgaccgaccttgag-3@#$%& of the enhancer ii of hepatitis b virus genes, a critical cis-element of their expression and regulation. may be responsable for the liver-specific activity of enhancer ii, probably in combination with other hepatocyte transcription factors. key regulator of cholesterol 7-alpha-hydroxylase gene (cyp7a) expression in liver. may also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
26816	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
26817	
26818	
26819	required for fusion of er-derived vesicles with the golgi during er-to-golgi protein transport, probably by mediating correct membrane localization of ypt1.
26820	
26821	
26822	
26823	
26824	
26825	
26826	appears to play a role in the switch from cap-dependent to ires-mediated translation during mitosis, apoptosis and viral infection. cleaved by some caspases and viral proteases.
26827	
26828	
26829	this protein is associated with sn-rnp u2. it helps the a@#$%& protein to bind stem loop iv of u2 snrna (by similarity).
26830	
26831	
26832	dual specificity protein phosphatase. may be involved in the control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules (polyglucosans).
26833	
26834	
26835	
26836	
26837	
26838	
26839	
26840	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. may govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
26841	gtpase-activating protein for rac1 and cdc42. promotes the exchange of rac or cdc42-bound gdp by gtp, thereby activating them. displays serine/threonine kinase activity.
26842	
26843	the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-coa and co(2). it contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (e1), lipoamide acyltransferase (e2) and lipoamide dehydrogenase (e3).
26844	
26845	
26846	
26847	
26848	
26849	
26850	
26851	
26852	
26853	probably functions as an alternative splicing regulator. may regulate the mrna splicing of genes such as clk1. may act by regulating members of the clk kinase family (by similarity).
26854	
26855	
26856	
26857	sperm surface antigen involved in some step of early cleavage of the fertilized oocyte.
26858	
26859	
26860	may be involved in transcriptional regulation.
26861	
26862	
26863	
26864	
26865	
26866	
26867	
26868	
26869	rapidly transports ca(2+) during excitation-contraction coupling. ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
26870	
26871	may regulate the disassembly of focal adhesions. may localize receptor-like tyrosine phosphatases type 2a at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
26872	
26873	
26874	
26875	may be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
26876	
26877	
26878	
26879	
26880	
26881	rna-binding protein that binds to several small cytoplasmic rna molecules known as y rnas. may stabilize these rnas from degradation.
26882	
26883	
26884	
26885	
26886	
26887	
26888	
26889	
26890	
26891	
26892	
26893	may be involved in transcriptional regulation.
26894	
26895	
26896	may be involved in tissue-specific alternative rna processing events.
26897	
26898	
26899	
26900	
26901	
26902	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
26903	
26904	
26905	may be required for testis development.
26906	involved in the transport of proteins between the endosomes and the trans golgi network (by similarity).
26907	
26908	
26909	plays a role in the import of cytosolically synthesized preproteins into mitochondria. binds the mature portion of precursor proteins. interacts with cellular components, and possesses weak atpase activity. may be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.
26910	
26911	
26912	
26913	
26914	required for protein transport from the er to the golgi complex.
26915	
26916	
26917	
26918	
26919	component of the origin recognition complex (orc) that binds origins of replication. it has a role in both chromosomal replication and mating type transcriptional silencing. binds to the ars consensus sequence (acs) of origins of replication in an atp-dependent manner.
26920	
26921	
26922	
26923	
26924	dna-binding protein that specifically binds heat shock promoter elements (hse) and activates transcription. in higher eukaryotes, hsf is unable to bind to the hse unless the cells are heat shocked.
26925	
26926	
26927	may be involved in transcriptional regulation.
26928	inhibitory effect on stress fiber organization. may down-regulate rho-like gtpase in hematopoietic cells.
26929	gtpase-activating protein for rac1 and cdc42. promotes the exchange of rac or cdc42-bound gdp by gtp, thereby activating them. displays serine/threonine kinase activity.
26930	
26931	transcription factor that binds to and transactivates the tshb promoter. binds to a minimal dna-binding sequence 5@#$%&- [tc][ag][ag]tta[tc][ag]-3@#$%&.
26932	
26933	
26934	could have a part in mechanisms of transcriptional regulation similar to that played by yeast hir1 and hir2 together.
26935	acts both in vulval induction and sex myoblast migration. presumably interacts with the kinase receptor let-23 and with a target that modifies the ras-like protein let-60.
26936	transcriptional regulator. may participate in transcriptional regulation through the recruitment of setdb1 histone methyltransferase and subsequent modification of local chromatin structure.
26937	
26938	
26939	
26940	
26941	
26942	
26943	
26944	binds the camp response element (cre) (consensus: 5@#$%&- gtgacgt[ag][ag]-3@#$%&), a sequence present in many viral and cellular promoters.
26945	
26946	most effectively accelerate the intrinsic gtpase activity of ypt7. it is also active, but to a lesser extent, on ypt31, ypt32 and ypt1. ypt6 and sec4.
26947	involved in poly(a)+ rna transport.
26948	
26949	
26950	involved in t-cell antigen receptor mediated signaling.
26951	
26952	
26953	
26954	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
26955	
26956	daughterless/achaete-scute complex heterodimers act as transcriptional activators of neural cell fates and are involved in sex determination.
26957	
26958	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity.
26959	possibly acts as a transcriptional regulatory factor.
26960	myosins are actin-based motor molecules with atpase activity. unconventional myosins serve in intracellular movements. may be involved in the remodeling of the actin cytoskeleton. binds actin with high affinity both in the absence and presence of atp and its mechanochemical activity is inhibited by calcium ions. also acts as a gtpase activating protein on rho.
26961	
26962	
26963	
26964	converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single arg-val bond in plasminogen. by controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. play a direct role in facilitating neuronal migration.
26965	
26966	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
26967	
26968	
26969	
26970	
26971	
26972	
26973	
26974	
26975	
26976	
26977	
26978	may play a role in neoplasia. may counteract a default induction of apoptosis in g2/m phase. interacts with tubulin. inhibitor of caspase-3 and caspase-7.
26979	
26980	
26981	
26982	
26983	terminates the action of gaba by its high affinity sodium-dependent reuptake into presynaptic terminals (by similarity).
26984	
26985	possible chloride ion channel.
26986	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
26987	may be involved in transcriptional regulation.
26988	
26989	
26990	
26991	
26992	
26993	
26994	
26995	
26996	component of the signaling pathway of il-1 and toll-like receptors. inhibits cell activation by microbial products. recruits irak1 to the il-1 receptor complex. inhibits irak1 phosphorylation and kinase activity.
26997	
26998	
26999	collagen type iv is specific for basement membranes.
27000	
27001	
27002	
27003	
27004	cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. has angiogenic inhibitor activity (by similarity). active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. may play a critical role in follicular rupture (by similarity).
27005	protein transport. probably involved in vesicular traffic (by similarity).
27006	
27007	
27008	
27009	
27010	
27011	
27012	transcription factor that binds to the interleukin-6 (il-6)-responsive elements identified in the promoters of various acute-phase protein genes.
27013	
27014	sperm surface antigen involved in some step of early cleavage of the fertilized oocyte.
27015	
27016	
27017	
27018	
27019	
27020	
27021	
27022	
27023	
27024	tm anchors the envelope heterodimer to the viral membrane through one transmembrane domain. the other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (by similarity).
27025	
27026	
27027	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. the alpha and alpha@#$%& chains contain the catalytic site. participates in wnt signaling. ck2 phosphorylates ser-392 of p53/tp53 following uv irradiation.
27028	
27029	
27030	
27031	
27032	
27033	
27034	sam (substrate-adhesion molecule) that appears to inhibit cell migration. may play a role in supporting the growth of epithelial tumors. is a ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-v/beta-3 and alpha-v/beta-6.
27035	dispensable for acquisition of thermotolerance and does not play a significant role in recovery or protection of cells from acute heat shock. may be implicated in one or possibly more pathways of mutagenesis in yeast. hydrolyzes atp and gtp yielding ppi.
27036	
27037	possible transcription factor. specifically binds to the ct/gc-rich region of the interleukin-3 promoter and mediates tax transactivation of il-3.
27038	plays an important role in the physiology of adrenergic neurons.
27039	could be involved in cell-cell interactions.
27040	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation via its interaction with the myocyte enhancer factors such as mef2a, mef2c and mef2d.
27041	
27042	transcriptional activator which binds to the enhancer of the t-cell receptor alpha and delta genes. binds to the consensus sequence 5@#$%&-agatag-3@#$%&.
27043	
27044	
27045	
27046	responsible for cleaving the alpha-chains of c4b and c3b in the presence of the cofactors c4-binding protein and factor h respectively.
27047	
27048	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
27049	
27050	
27051	
27052	facilitative glucose transporter. probably a neuronal glucose transporter.
27053	
27054	
27055	
27056	
27057	
27058	
27059	
27060	
27061	
27062	
27063	
27064	may act as a scaffolding protein within caveolar membranes. interacts directly with g-protein alpha subunits and can functionally regulate their activity. caveolin-2 may function as an accessory protein in conjunction with caveolin-1.
27065	
27066	
27067	
27068	
27069	
27070	
27071	binds specifically to the dna sequence 5@#$%&-aacaat-3@#$%&. activates transcription of col2a1 and agc1 in vitro.
27072	
27073	
27074	may act as a gtpase activating protein for rab family protein(s).
27075	may play specific roles in sperm maturation or fertilization (by similarity).
27076	
27077	
27078	
27079	
27080	
27081	binds gangliosides and stimulates ganglioside gm2 degradation. it stimulates only the breakdown of ganglioside gm2 and glycolipid ga2 by beta-hexosaminidase a. it extracts single gm2 molecules from membranes and presents them in soluble form to beta-hexosaminidase a for cleavage of n-acetyl-d-galactosamine and conversion to gm3.
27082	involved in the maturation of asn-linked oligosaccharides. trim alpha-1,2-linked mannose residues from man(9)glcnac(2) to produce first man(8)glcnac(2) then man(6)glcnac and a small amount of man(5)glcnac.
27083	binds to cug triplet repeat expansion dsrna (by similarity).
27084	
27085	
27086	
27087	
27088	
27089	
27090	
27091	
27092	rna-dependent atpase activity.
27093	may play a role in anchoring the cytoskeleton to the plasma membrane.
27094	
27095	
27096	
27097	
27098	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
27099	
27100	
27101	
27102	
27103	
27104	may be involved in transcriptional regulation.
27105	
27106	
27107	
27108	
27109	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
27110	this is a receptor for corticotropin releasing factor. shows high-affinity crf binding. also binds to urocortin i, ii and iii. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
27111	
27112	
27113	
27114	involved in the maturation of asn-linked oligosaccharides. progressively trim alpha-1,2-linked mannose residues from man(9)glcnac(2) to produce man(5)glcnac(2).
27115	
27116	
27117	
27118	
27119	
27120	
27121	plays a role in transcriptional coactivation.
27122	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. the light chain may function in coupling of cargo to the heavy chain or in the modulation of its atpase activity (by similarity).
27123	
27124	plays a role in protein sorting and trafficking between the trans-golgi network (tgn) and endosomes. mediates the arf- dependent recruitment of clathrin to the tgn and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (ac-ll) motif.
27125	transcriptional regulator that probably plays an important role in lymphomagenesis.
27126	
27127	
27128	
27129	
27130	specialized low-affinity urea transporter. mediates urea transport in erythrocytes.
27131	
27132	
27133	
27134	
27135	
27136	links covalently the heme group to the apoprotein of cytochrome c (by similarity).
27137	essential component of the tim23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
27138	
27139	
27140	component of the copii coat, that covers er-derived vesicles involved in transport from the endoplasmic reticulum to the golgi apparatus. copii is composed of at least five proteins: the sec23/24 complex, the sec13/31 complex, and the protein sar1. acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex (by similarity).
27141	
27142	
27143	
27144	
27145	component of a putative tumor-recognition complex. involved in the function of nk cells.
27146	probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. may be involved in the uptake of lipoprotein apoe in liver (by similarity).
27147	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
27148	
27149	
27150	
27151	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
27152	
27153	
27154	
27155	
27156	
27157	receptor for vegfc. has a tyrosine-protein kinase activity.
27158	
27159	
27160	
27161	
27162	
27163	
27164	
27165	
27166	transcription factor that binds to the octamer motif (5@#$%&-atttgcat-3@#$%&) and activates the promoters of the genes for some small nuclear rnas (snrna) and of genes such as those for histone h2b and immunoglobulins. modulates transcription transactivation by nr3c1, ar and pgr (by similarity).
27167	hydrolyzes a variety of proteins.
27168	
27169	
27170	
27171	
27172	
27173	
27174	
27175	
27176	
27177	
27178	
27179	
27180	
27181	
27182	muscle contraction.
27183	
27184	
27185	
27186	
27187	
27188	
27189	
27190	
27191	
27192	
27193	
27194	component of the peroxisomal translocation machinery with pex14 and pex17. functions as a docking factor for the predominantly cytoplasmic pts1 receptor (pas10/pex5). involved in the import of pts1 and pts2 proteins.
27195	
27196	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
27197	
27198	
27199	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. preferentially uses palmitoleate, oleate and linoleate.
27200	
27201	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
27202	
27203	
27204	
27205	may antagonize nodal signaling and subsequent organization of axial structures during mesodermal patterning (by similarity).
27206	
27207	
27208	
27209	
27210	
27211	may play a role in the cellular processing of insulin. may be involved in intercellular peptide signaling.
27212	the soluble isoform 2 binds vegf-165 and appears to inhibit its binding to cells. it may also induce apoptosis by sequestering vegf-165. may bind as well various members of the semaphorin family. its expression has an averse effect on blood vessel number and integrity.
27213	rna and ssdna-binding protein that may play specific roles during transcription initiation at distinct promoters. can enter the preinitiation complex together with the rna polymerase ii (pol ii).
27214	
27215	
27216	
27217	
27218	
27219	
27220	cellular role is not yet known.
27221	
27222	
27223	
27224	
27225	
27226	
27227	
27228	sequence-selective dna-binding protein. could play an important role in gene regulation.
27229	may activate cdc42, a member of the ras-like family of rho- and rac proteins, by exchanging bound gdp for free gtp. may play a role in regulating the actin cytoskeleton and cell shape (by similarity).
27230	in presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
27231	
27232	
27233	
27234	
27235	
27236	involved in transport of proteins from the cis/medial- golgi to the trans-golgi network.
27237	
27238	
27239	
27240	
27241	
27242	
27243	
27244	
27245	plays a role as an intracellular lectin in the early secretory pathway. interacts with n-acetyl-d-galactosamine and high-mannose type glycans and may also bind to o-linked glycans. involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (by similarity).
27246	
27247	
27248	
27249	
27250	
27251	
27252	calcium-regulated non-lysosomal thiol-protease (by similarity).
27253	in presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
27254	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
27255	
27256	
27257	
27258	
27259	
27260	
27261	
27262	
27263	
27264	desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
27265	involved in high-affinity copper uptake.
27266	
27267	
27268	may act at junctions between the membrane and the cytoskeleton.
27269	integrin alpha-v/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von willebrand factor. integrin alpha-iib/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. integrins alpha-iib/beta-3 and alpha-v/beta-3 recognize the sequence r-g-d in a wide array of ligands. integrin alpha-iib/beta-3 recognizes the sequence h-h-l-g-g-g-a-k-q-a-g-d-v in fibrinogen gamma chain. following activation integrin alpha- iib/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. this step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
27270	
27271	
27272	
27273	
27274	
27275	stimulates the proliferation of mast cells. able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. mediates also cell-cell adhesion. acts synergistically with other cytokines, probably interleukins.
27276	
27277	
27278	may play a structural role at sites of cell adhesion in maintaining cell shape and motility. in addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. may be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
27279	co-chaperone of hsc70.
27280	collagen type iii occurs in most soft connective tissues along with type i collagen.
27281	
27282	
27283	
27284	
27285	
27286	
27287	
27288	
27289	involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of dna-nucleosome topology). binds dna non-specifically.
27290	
27291	
27292	
27293	
27294	
27295	
27296	
27297	
27298	
27299	sequence-specific rna-binding protein which participates in the control of pre-mrna splicing.
27300	
27301	
27302	
27303	
27304	
27305	
27306	
27307	
27308	
27309	
27310	
27311	
27312	
27313	
27314	
27315	
27316	
27317	
27318	
27319	
27320	
27321	
27322	
27323	
27324	
27325	
27326	probable transcription factor.
27327	
27328	may bind rna.
27329	promotes the exchange of ras-bound gdp by gtp.
27330	promotes the exchange of ran-bound gdp by gtp. involved in the regulation of onset of chromosome condensation in the s phase. binds to the chromatin. rcc1/ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated dna.
27331	
27332	
27333	
27334	
27335	
27336	
27337	
27338	
27339	
27340	
27341	
27342	
27343	
27344	
27345	
27346	receptor for members of the ephrin-a family. binds to ephrin-a1, -a2, -a3, -a4 and -a5.
27347	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
27348	
27349	
27350	
27351	
27352	
27353	may play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (by similarity).
27354	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
27355	
27356	inhibits the chaperone activity of hsp70/hsc70 by promoting substrate release (by similarity). prevents constitutive tnfrsf1a signaling.
27357	
27358	
27359	
27360	
27361	
27362	
27363	
27364	
27365	
27366	
27367	acyl-coa thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-coas to the free fatty acid and coenzyme a (coash), providing the potential to regulate intracellular levels of acyl-coas, free fatty acids and coash. may play an important physiological function in brain. may play a regulatory role by modulating the cellular levels of fatty acyl- coa ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. has broad specificity, active towards fatty acyl-coas with chain-lengths of c8-c18. has a maximal activity toward palmitoyl-coa.
27368	
27369	converts arachidonic acid to 15s- hydroperoxyeicosatetraenoic acid. also acts on c-12 of arachidonate as well as on linoleic acid.
27370	
27371	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
27372	
27373	
27374	involved in the transport of chloride ions. may regulate bicarbonate secretion and salvage in epithelial cells by regulating the slc4a7 transporter.
27375	
27376	high affinity receptor for sphingosylphosphorylcholine, coupled to g proteins that stimulate phosphoinositide hydrolysis.
27377	the heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.
27378	required for protein transport from the er to the golgi complex.
27379	
27380	
27381	
27382	
27383	
27384	
27385	
27386	
27387	
27388	
27389	
27390	
27391	
27392	
27393	
27394	transcriptional repressor.
27395	
27396	
27397	
27398	
27399	plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. this phosphodiesterase has a high affinity for cgmp.
27400	
27401	
27402	
27403	
27404	required for protein transport from the er to the golgi complex.
27405	
27406	
27407	
27408	
27409	
27410	
27411	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
27412	histone h3, along with histone h4, plays a central role in nucleosome formation.
27413	
27414	
27415	
27416	
27417	
27418	
27419	
27420	participates in the apoptotic response to dna damage. when overproduced, activates transcription from p53-responsive promoters and induces apoptosis. may be a tumor suppressor protein.
27421	
27422	
27423	
27424	
27425	
27426	
27427	
27428	
27429	
27430	
27431	
27432	
27433	
27434	adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. alpha adaptin is a subunit of the plasma membrane adaptor. binds polyphosphoinositides (by similarity).
27435	binds to tie2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. its function may be context-dependent. in the absence of angiogenic inducers, such as vegf, ang2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. in concert with vegf, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
27436	
27437	
27438	
27439	required for the binding of mrna to ribosomes. functions in close association with eif4-f and eif4-a. binds near the 5@#$%&- terminal cap of mrna in presence of eif-4f and atp. promotes the atpase activity and the atp-dependent rna unwinding activity of both eif4-a and eif4-f.
27440	receptor for interleukin-1 alpha (il-1a), beta (il-1b), and interleukin-1 receptor antagonist protein (il-1ra). binding to the agonist leads to the activation of nf-kappa-b. signaling involves formation of a ternary complex containing il1rap, tollip, myd88, and irak1 or irak2.
27441	
27442	involved in axon growth. plays an essential role in neurite extension of cerebellar granule cells.
27443	
27444	
27445	
27446	cytokine that binds to tnfrsf11b/opg and to tnfrsf11a/rank. osteoclast differentiation and activation factor. augments the ability of dendritic cells to stimulate naive t-cell proliferation. may be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
27447	histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a role in histone code. does not demethylate histone h3 lys-4, h3 lys-27, h3 lys-36 nor h4 lys-20. only able to demethylate trimethylated h3 lys-9, with a weaker activity than jmjd2a, jmjd2c and jmjd2d. demethylation of lys residue generates formaldehyde and succinate.
27448	
27449	
27450	
27451	
27452	
27453	
27454	
27455	type i collagen is a member of group i collagen (fibrillar forming collagen).
27456	
27457	
27458	
27459	
27460	transcriptional activator (by similarity). binds a gc box motif. could play a role in b-cell growth and development.
27461	isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
27462	
27463	
27464	
27465	
27466	accelerates programmed cell death. binding to the apoptosis repressors bcl-x(l), bhrf1, bcl-2 or its adenovirus homolog e1b 19k protein suppresses this death-promoting activity. does not interact with bax.
27467	
27468	
27469	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
27470	
27471	
27472	
27473	
27474	
27475	protein transport. probably involved in vesicular traffic (by similarity).
27476	
27477	constituent of copii-coated endoplasmic reticulum- derived transport vesicles. required for efficient transport of a subset of secretory proteins to the golgi. the c-terminal ile-leu motif is required for exit from the endoplasmic reticulum. facilitates retrograde transport from the golgi to the endoplasmic reticulum.
27478	implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. may be involved in the regulation of perinuclear intravesicular membrane traffic (by similarity).
27479	
27480	
27481	catalyzes the reversible synthesis of acetylcholine (ach) from acetyl coa and choline at cholinergic synapses.
27482	carries 11-cis-retinol and 11-cis-retinaldehyde as endogenous ligands and may be a functional component of the visual cycle.
27483	
27484	orphan nuclear receptor. may regulate gene expression during the late phase of spermatogenesis.
27485	
27486	
27487	
27488	
27489	
27490	
27491	non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via g-protein coupled receptor (gpcr) occupancy by ligands such as bombesin or lysophosphatidic acid, or via ldl receptor occupancy. plays a potential role in oncogenic transformations resulting in increased kinase activity.
27492	
27493	
27494	c-terminal alpha-amidation of peptides. the reaction produces a peptidyl(2-hydroxyglycine) intermediate is unstable and dismutates to glyoxylate and the corresponding desglycine peptide amide.
27495	the 26s protease is involved in the atp-dependent degradation of ubiquitinated proteins. the regulatory (or atpase) complex confers atp dependency and substrate specificity to the 26s complex (by similarity).
27496	
27497	
27498	
27499	
27500	
27501	
27502	
27503	
27504	could be a melanogenic enzyme (by similarity).
27505	
27506	
27507	
27508	
27509	involved in cytokinesis (potential).
27510	
27511	
27512	
27513	
27514	muscle contraction.
27515	most effectively accelerate the intrinsic gtpase activity of ypt7. it is also active, but to a lesser extent, on ypt31, ypt32 and ypt1. ypt6 and sec4.
27516	
27517	palmitoyltransferase specific for vac8. palmitoylates vac8 at one or more of its n-terminal cysteine residues, which is required for its proper membrane localization.
27518	seems to act as an ig mutase which is responsible for immunoglobulin (ig) gene hypermutation.
27519	
27520	
27521	
27522	
27523	produces nitric oxide (no) which is a messenger molecule with diverse functions throughout the body. in the brain and peripheral nervous system, no displays many properties of a neurotransmitter.
27524	
27525	
27526	
27527	
27528	may play a functional role in the cell filament networks.
27529	
27530	involved in the protein trafficking from the golgi apparatus to the plasma membrane (by similarity).
27531	
27532	
27533	
27534	
27535	
27536	
27537	
27538	the substrate transported is not yet known. induces mitochondrial depolarization.
27539	
27540	promotes the exchange of gdp by gtp. together with leukocyte antigen-related (lar) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.
27541	p65 is a subunit of the nuclear factor kappa-b, a second messenger, which activates the transcription of a number of genes in multiple tissues. the inhibitory effect of i-kappa-b upon nf- kappa-b in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak dna-binding site which could contribute directly to dna binding in the nf-kappa-b complex.
27542	
27543	
27544	
27545	
27546	
27547	
27548	
27549	
27550	
27551	
27552	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. the alpha and alpha@#$%& chains contain the catalytic site. participates in wnt signaling. ck2 phosphorylates ser-392 of p53/tp53 following uv irradiation.
27553	
27554	
27555	promotes the exchange of ras-bound gdp by gtp.
27556	
27557	
27558	
27559	
27560	
27561	may mediate the transduction of intracellular signals.
27562	
27563	
27564	major airway glycoprotein.
27565	
27566	
27567	
27568	may play a fundamental role in situations where fine interplay between intracellular calcium and camp determines the cellular function. may be a physiologically relevant docking site for calcineurin (by similarity).
27569	
27570	may be involved in transcriptional regulation.
27571	
27572	
27573	
27574	
27575	
27576	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
27577	
27578	
27579	this is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters. may be considered as a novel component of the nf-kappa-b signaling axis responsible for the survival and activation of b-cells after bcr cross-linking (by similarity).
27580	general protein kinase capable of phosphorylating several known proteins.
27581	
27582	
27583	
27584	
27585	
27586	
27587	
27588	involved in vesicular protein trafficking.
27589	
27590	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
27591	positive effector of bcr-stimulated responses. couples the b-cell antigen receptor (bcr) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase c-gamma-dependent pathway, when phosphorylated on tyr-342 and tyr-346. thus the differential phosphorylation of syk can determine the pathway by which bcr is coupled to the regulation of intracellular calcium ion.
27592	
27593	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
27594	
27595	rapidly transports ca(2+) during excitation-contraction coupling. ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
27596	
27597	
27598	
27599	
27600	destroys radicals which are normally produced within the cells and which are toxic to biological systems.
27601	
27602	l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists. may be involved in the transmission of light information from the retina to the hypothalamus. this receptor binds domoate > kainate > quisqualate > 6-cyano-7-nitroquinoxaline-2,3-dione > l-glutamate = 6,7- dinitroquinoxaline-2,3-dione > dihydrokainate.
27603	
27604	
27605	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. the n-terminus interacts with and regulates xpd whereas an intact c- terminus is required for a successful escape of rnap ii form the promoter.
27606	
27607	
27608	required for protein transport from the er to the golgi complex.
27609	catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
27610	plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. agonist-dependent changes in lasp1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other f-actin-rich secretory epithelial cell types (by similarity).
27611	
27612	
27613	
27614	
27615	snare involved in a vesicular transport step within the golgi stack.
27616	
27617	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems. the g(o) protein function is not clear.
27618	
27619	cysteine protease. may have an important role in corneal physiology.
27620	may act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
27621	
27622	
27623	involved in the presentation of foreign antigens to the immune system.
27624	
27625	
27626	
27627	
27628	
27629	
27630	
27631	
27632	
27633	
27634	
27635	
27636	
27637	
27638	
27639	
27640	molecular chaperone; assist the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
27641	
27642	
27643	
27644	mediates estrogen action in various target organs.
27645	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes.
27646	
27647	
27648	
27649	
27650	
27651	
27652	
27653	
27654	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
27655	
27656	
27657	
27658	
27659	
27660	may be involved in zinc transport out of the cell.
27661	
27662	may be involved in transcriptional regulation.
27663	
27664	
27665	transcriptional repressor. binds to caccc-boxes promoter elements.
27666	
27667	
27668	
27669	
27670	p65 is a subunit of the nuclear factor kappa-b, a second messenger, which activates the transcription of a number of genes in multiple tissues. the inhibitory effect of i-kappa-b upon nf- kappa-b in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak dna-binding site which could contribute directly to dna binding in the nf-kappa-b complex.
27671	
27672	
27673	involved in intracellular signal transduction mediated by cytokines and growth factors. when associated with stam, it suppresses dna signaling upon stimulation by il-2 and gm-csf. could be a direct effector of pi3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. may concentrate ubiquitinated receptors within clathrin-coated regions. involved in down- regulation of receptor tyrosine kinase via multivesicular body (mvbs) when complexed with stam. this complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. may contribute to the efficient recruitment of smads to the activin receptor complex.
27674	histone methyltransferase. methylates lys-9 of histone h3 (in vitro). h3 lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting hp1 proteins to methylated histones. probably targeted to histone h3 by different dna-binding proteins like e2f6, mga, max and/or dp1. during g0 phase, it probably contributes to silencing of myc- and e2f-responsive genes, suggesting a role in g0/g1 transition in cell cycle.
27675	
27676	
27677	
27678	
27679	
27680	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. may be implicated in the folding, transport, and assembly of proteins. may play an important role in the regulation of pre-mrna splicing.
27681	
27682	
27683	docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. dok3 is a negative regulator of jnk signaling in b-cells through interaction with inpp5d/ship. may modulate abl function (by similarity).
27684	histone demethylase that specifically demethylates lys-9 and lys-36 residues of histone h3, thereby playing a central role in histone code. does not demethylate histone h3 lys-4, h3 lys-27 nor h4 lys-20. demethylates trimethylated h3 lys-9 and h3 lys-36 residue, while it has no activity on mono- and dimethylated residues. demethylation of lys residue generates formaldehyde and succinate.
27685	
27686	
27687	
27688	
27689	
27690	
27691	
27692	
27693	
27694	
27695	may play a role in regulating interactions between dynein and p150-glued, and the cellular substrates for dynein- mediated motility (such as organelles) (by similarity).
27696	
27697	
27698	
27699	
27700	pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
27701	
27702	
27703	
27704	may be involved in transcriptional regulation.
27705	
27706	positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (mrlc). it prevents mir-mediated mrlc ubiquitination and its subsequent proteasomal degradation.
27707	major component of the vertebrate myofibrillar m band. binds myosin, titin, and light meromyosin. this binding is dose dependent.
27708	
27709	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb (by similarity).
27710	
27711	this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of sodium and potassium ions across the plasma membrane. this action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
27712	
27713	
27714	
27715	
27716	transcriptional repressor of genes that require a bhlh protein for their transcription. may act as a negative regulator of myogenesis by inhibiting the functions of myod1 and ash1 (by similarity).
27717	receptor for gastrin releasing peptide (grp). this receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system.
27718	cleaves a-5@#$%&-ppp-5@#$%&a to yield amp and adp. possible tumor suppressor for specific tissues.
27719	
27720	specifically removes c-terminal basic residues (arg or lys) from peptides and proteins. it is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.
27721	
27722	
27723	
27724	
27725	
27726	
27727	
27728	
27729	transcription activator for a number of liver genes such as afp, albumin, tyrosine aminotransferase, pepck, etc. interacts with the cis-acting regulatory regions of these genes.
27730	
27731	may be involved in transcriptional regulation.
27732	
27733	provides cdp-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (ptdins), phosphatidylglycerol, and cardiolipin. overexpression may amplify cellular signaling responses from cytokines. may also play an important role in the signal transduction mechanism of retina and neural cells.
27734	
27735	
27736	
27737	
27738	acts as a transcriptional repressor. interacts with mxi1 to repress myc responsive genes and antagonize myc oncogenic activities. interacts with mad-max heterodimers by binding to mad. the heterodimer then represses transcription by tethering sin3b to dna. also forms a complex with foxk1 which represses transcription (by similarity).
27739	microtubule-dependent motor required for slow axonal transport of neurofilament proteins (nfh, nfm and nfl) (by similarity).
27740	rna-binding protein. associated to polysomes and might be involved in the transport of mrna from the nucleus to the cytoplasm.
27741	
27742	
27743	binds to the bem1 protein.
27744	
27745	may be signaling molecules that resemble neuropeptides. ligand for alpha-neurexins (by similarity).
27746	
27747	
27748	
27749	acts as catalytic component of the ccr4-not core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mrna deadenylase involved in mrna turnover. ccr4 has 3@#$%&-5@#$%& rnase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single stranded dna. discovered because of its role in the control of adh2 gene expression. it is required for the expression of genes involved in nonfermentative growth and it mediates or is required for the action of the spt6 and spt10 genes.
27750	involved in the degradation of asparagine-linked glycoproteins. hydrolyze of n-acetyl-beta-d-glucosamine (1-4)n- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.
27751	
27752	
27753	sodium-dependent and purine-selective. exhibits the transport characteristics of the nucleoside transport system cif or n1 subtype (n1/cif) (selective for purine nucleosides and uridine) (by similarity).
27754	
27755	
27756	
27757	
27758	
27759	
27760	non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via g-protein coupled receptor (gpcr) occupancy by ligands such as bombesin or lysophosphatidic acid, or via ldl receptor occupancy. plays a potential role in oncogenic transformations resulting in increased kinase activity.
27761	
27762	
27763	
27764	
27765	
27766	
27767	
27768	motor required for the retrograde transport of golgi vesicles to the endoplasmic reticulum. has a microtubule plus end- directed motility.
27769	
27770	
27771	
27772	
27773	
27774	
27775	
27776	
27777	
27778	involved in the degradation of prenylated proteins. cleaves the thioether bond of prenyl-l-cysteines, such as farnesylcysteine and geranylgeranylcysteine.
27779	probable transcriptional activator.
27780	stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal dna fragmentation.
27781	
27782	potential calcium-dependent cell-adhesion protein. may be involved in the establishment and maintenance of specific neuronal connections in the brain.
27783	component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnrnp). hnrnp play an important role in processing of precursor mrna in the nucleus.
27784	
27785	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
27786	
27787	thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. during neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (by similarity). slit1 and slit2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.
27788	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. may play an important role in retinal development.
27789	
27790	
27791	
27792	
27793	
27794	
27795	general activator of rna polymerase iii transcription.
27796	
27797	
27798	
27799	
27800	
27801	type i collagen is a member of group i collagen (fibrillar forming collagen).
27802	
27803	probable helicase, which may be involved in rna maturation (by similarity).
27804	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the complex p170-eif3.
27805	
27806	
27807	
27808	may play a significant role in aauaaa-independent mrna polyadenylation in germ cells. directly involved in the binding to pre-mrnas (by similarity).
27809	
27810	
27811	
27812	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
27813	
27814	has an atp-independent isopeptidase activity, cleaving at the c-terminus of the ubiquitin moiety. in vitro, isoform 2, but not isoform 3, shows deubiquitinating activity.
27815	
27816	
27817	reversible hydration of carbon dioxide.
27818	
27819	
27820	
27821	ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. modulates the gating kinetics and enhances stability of the channel complex. assembled with kcnq1/kvlqt1 is proposed to form the slowly activating delayed rectifier cardiac potassium (iks) channel. the outward current reaches its steady state only after 50 seconds. assembled with kcnh2/herg may modulate the rapidly activating component of the delayed rectifying potassium current in heart (ikr).
27822	
27823	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
27824	
27825	
27826	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
27827	
27828	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
27829	
27830	activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. plays an important role in fatty acid metabolism in brain and the acyl-coas produced may be utilized exclusively for the synthesis of the brain lipid.
27831	
27832	
27833	
27834	
27835	may be involved in transcriptional regulation.
27836	
27837	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
27838	
27839	controls phosphatidylcholine synthesis.
27840	
27841	
27842	
27843	
27844	
27845	mbp1 binds to the c-myc promoter and acts as a transcriptional repressor. may be a tumor suppressor.
27846	
27847	component of the mrn complex, which plays a central role in double-strand break (dsb) repair, dna recombination, maintenance of telomere integrity and meiosis. the complex possesses single-strand endonuclease activity and double-strand- specific 3@#$%&-5@#$%& exonuclease activity, which are provided by mre11a. rad50 may be required to bind dna ends and hold them in close proximity. this could facilitate searches for short or long regions of sequence homology in the recombining dna templates, and may also stimulate the activity of dna ligases and/or restrict the nuclease activity of mre11a to prevent nucleolytic degradation past a given point. the complex may also be required for dna damage signaling via activation of the atm kinase. in telomeres the mrn complex may modulate t-loop formation.
27848	
27849	type i collagen is a member of group i collagen (fibrillar forming collagen).
27850	
27851	
27852	
27853	
27854	
27855	probable atpase involved in the assembly or function of nuclear protein complexes. may also be involved in some aspects of microtubule dynamics (by similarity).
27856	gtpase-activating protein for the adp ribosylation factor family (potential).
27857	
27858	
27859	
27860	
27861	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
27862	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. rna polymerase i is essentially used to transcribe ribosomal dna units.
27863	
27864	
27865	
27866	
27867	helicase; has atpase activity.
27868	
27869	
27870	
27871	
27872	
27873	
27874	
27875	catalyzes the transfer of ptdins and phosphatidylcholine between membranes.
27876	
27877	
27878	
27879	neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. may play a role in formation or maintenance of synaptic junctions. may mediate intracellular signaling.
27880	
27881	
27882	
27883	binds to regulatory subunit (rii) of protein kinase a. may be involved in establishing polarity in signaling systems or in integrating pka-rii isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by camp (by similarity).
27884	
27885	
27886	
27887	
27888	
27889	
27890	
27891	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
27892	
27893	
27894	
27895	
27896	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
27897	
27898	required for protein transport from the er to the golgi complex.
27899	
27900	
27901	
27902	
27903	
27904	
27905	
27906	
27907	
27908	
27909	
27910	
27911	
27912	binds the poly(a) tail of mrna. may be involved in cytoplasmic regulatory processes of mrna metabolism. its function in translational initiation regulation can either be enhanced by paip1 or repressed by paip2. can probably bind to cytoplasmic rna sequences other than poly(a) in vivo. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain (by similarity).
27913	
27914	activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (apc/c). during telophase and in the subsequent g1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (d-box) and an additional degradation signal termed the ken box including ase1, cdc20, the b-type cyclins clb2 and clb3, the polo-like kinase cdc5 and hsl1, and recruits them in a c-box-dependent manner to the apc/c for ubiquitination and subsequent proteolysis. required for exit from mitosis, cytokinesis and formation of prereplicative complexes in g1. probably is the target of a bub2-dependent spindle checkpoint pathway.
27915	
27916	
27917	
27918	
27919	cleaves peptide bonds on the c-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
27920	
27921	
27922	
27923	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
27924	
27925	
27926	
27927	type ii regulatory chains mediate membrane association by binding to anchoring proteins, including the map2 kinase.
27928	
27929	
27930	may be required for neuronal cell differentiation.
27931	
27932	binds to the sequences 5@#$%&-aatgtaggtca-3@#$%& and 5@#$%&- ataactaggtca-3@#$%&. acts as a potent competitive repressor of ror alpha function (by similarity).
27933	
27934	
27935	
27936	
27937	
27938	
27939	
27940	
27941	
27942	
27943	receptor for ptpns1. may play a role in membrane transport and/or signal transduction. may prevent premature elimination of red blood cells. may be involved in membrane permeability changes induced following virus infection. may play a role in memory formation. has a role in cell adhesion.
27944	
27945	
27946	
27947	
27948	
27949	
27950	calcium channel protein which plays an important role in excitation-contraction coupling.
27951	supports the intracellular pip pool and to a lesser extent, the pi 4,5-p(2) pool. it generates pip from pi and, to a lesser extent, pi 4,5-p(2) from pi 4-p. there are indications that it phosphorylates the d-5 rather than the d-4 position. has a role in endosome-related membrane trafficking (by similarity).
27952	
27953	may function as a transcription factor.
27954	plays a critical role in the generation of 28s rrna.
27955	
27956	chemoattractant active on t-lymphocytes, monocytes, but not neutrophils. sdf-1-beta(3-72) and sdf-1-alpha(3-67) show a reduced chemotactic activity. binding to cell surface proteoglycans seems to inhibit formation of sdf-1-alpha(3-67) and thus to preserve activity on local sites.
27957	plays a general role in the hierarchies of gene expression leading to metamorphosis.
27958	
27959	
27960	
27961	
27962	actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells.
27963	
27964	
27965	
27966	may play a role in rna metabolism.
27967	may play a role in neuron-specific rna processing.
27968	
27969	
27970	dna-binding protein that binds to the 5@#$%&-aata[ct]-3@#$%& core sequence. probably acts as a transcription regulator. represses the cytomegalovirus enhancer. overexpression leads to induction of smooth muscle marker genes, suggesting that it may act as a regulator of smooth muscle cell differentiation and proliferation. may be involved in lipid stores.
27971	activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (apc/c). during telophase and in the subsequent g1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (d-box) and an additional degradation signal termed the ken box including ase1, cdc20, the b-type cyclins clb2 and clb3, the polo-like kinase cdc5 and hsl1, and recruits them in a c-box-dependent manner to the apc/c for ubiquitination and subsequent proteolysis. required for exit from mitosis, cytokinesis and formation of prereplicative complexes in g1. probably is the target of a bub2-dependent spindle checkpoint pathway.
27972	may play a role in growth and differentiation of tissues involved in metabolic control. may play a regulatory role during g0/g1 transition of cell growth.
27973	
27974	
27975	
27976	iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones t(3) and t(4).
27977	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
27978	
27979	
27980	
27981	
27982	
27983	
27984	interconverts glcnac-6-p and glcnac-1-p.
27985	may play a role in notch signaling (by similarity).
27986	
27987	
27988	functions as an e1 enzyme essential for multisubstrates such as gabarapl1 and atg12. forms intermediate conjugates with gabarapl1 (gabarapl2, gabarap or map1alc3). formation of the final gabarapl1-pe conjugate is essential for autophagy (by similarity).
27989	
27990	
27991	
27992	
27993	
27994	
27995	
27996	
27997	
27998	
27999	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. isoform alpha-1i gives rise to t-type calcium currents. t-type calcium channels belong to the @#$%!low-voltage activated (lva)@#$%! group and are strongly blocked by nickel and mibefradil. a particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. t-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. they may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. gates in voltage ranges similar to, but higher than alpha 1g or alpha 1h (by similarity).
28000	
28001	rab effector protein acting as linker between gamma- adaptin, rab4a and rab5a. involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. stimulates rabgef1 mediated nucleotide exchange on rab5a.
28002	
28003	plays a role in cytoplasmic trafficking of rna. binds to the cis-acting response element, a2re.
28004	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
28005	
28006	calcium-dependent mitochondrial solute carrier (by similarity).
28007	required for learning most likely through its role in synaptic plasticity following nmda receptor signaling.
28008	component of the escrt-iii complex, which is required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs. the mvb pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. the escrt-iii complex is probably involved in the concentration of mvb cargo. required for sorting/trafficking of egf receptor. in case of infection, the hiv-1 virus takes advantage of the escrt-iii complex for budding and exocytic cargos of viral proteins.
28009	
28010	
28011	subunit of the splicing factor sf3b required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex. belongs also to the minor u12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mrna intron.
28012	the 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-coa and co(2). it contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (e1), dihydrolipoamide succinyltransferase (e2) and lipoamide dehydrogenase (e3).
28013	
28014	tyrosine kinase, that after binding to cdc42, inhibits both its intrinsic and stimulated gtpase activity.
28015	might act as an e3 ubiquitin-protein ligase, or as part of e3 complex, which accepts ubiquitin from specific e2 ubiquitin- conjugating enzymes, such as ube2l3/ubcm4, and then transfers it to substrates.
28016	
28017	
28018	
28019	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
28020	
28021	
28022	may play a role in the regulation of plasmin-mediated matrix remodeling. inhibits trypsin, plasmin, factor viia/tissue factor and weakly factor xa. has no effect on thrombin.
28023	may be involved in n-glycosylation through its association with n-oligosaccharyl transferase.
28024	
28025	probable helicase, which may be involved in rna maturation (by similarity).
28026	
28027	
28028	
28029	
28030	exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in trnas with gu(n) anticodons (trna-asp, -asn, -his and -tyr). after this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (by similarity).
28031	
28032	cbf binds to the core site, 5@#$%&-pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, lck, il-3 and gm-csf promoters. the alpha subunit binds dna and appears to have a role in the development of normal hematopoiesis. isoform aml-1l interferes with the transactivation activity of runx1. acts synergistically with elf4 to transactivate the il-3 promoter and with elf2 to transactivate the mouse blk promoter. inhibits myst4- dependent transcriptional activation.
28033	
28034	
28035	receptor for neurturin. mediates the nrtn-induced autophosphorylation and activation of the ret receptor. also able to mediate gdnf signaling through the ret tyrosine kinase receptor.
28036	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex.
28037	muscle contraction.
28038	helicase; has atpase activity.
28039	co-chaperone of hsc70. seems to play a role in protein import into mitochondria.
28040	plays an important role in the eukaryotic peptide chain initiation process.
28041	
28042	probably required for kinetochore function, involved in chromosome segregation during mitosis. interacts with retinoblastoma protein (rb), cenp-e and bubr1.
28043	
28044	
28045	
28046	
28047	attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to na-k atpase, to the lymphocyte membrane protein gp85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. in skeletal muscle, isoform mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
28048	
28049	
28050	
28051	may function as an output molecule from the suprachiasmatic nucleus (scn) that transmits behavioral circadian rhythm. may also function locally within the scn to synchronize output. potently contracts gastrointestinal (gi) smooth muscle (by similarity).
28052	
28053	receptor for a c-c type chemokine. binds to mip-1-alpha, mip-1-beta and rantes and subsequently transduces a signal by increasing the intracellular calcium ions level.
28054	
28055	may play a role in cell differentiation in the intestinal epithelium.
28056	this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity.
28057	
28058	
28059	
28060	
28061	drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively. binds f-actin.
28062	
28063	participates in wnt signaling (by similarity). plays a complex role in regulating the basal catalytic activity of the alpha subunit.
28064	
28065	receptor for somatostatin-28. the activity of this receptor is mediated by g proteins which inhibit adenylyl cyclase.
28066	
28067	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
28068	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
28069	modulates tnf alpha signaling.
28070	may be involved in several stages of intracellular trafficking (by similarity).
28071	
28072	
28073	transcription factor that regulates cit2 gene expression. binds to two identical sites oriented as inverted repeats 28 bp apart in a regulatory upstream activation sequence element (uasr) in the cit2 promoter. the core binding site is 5@#$%&- ggtcac-3@#$%&.
28074	likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
28075	unknown.
28076	may participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ice)-like proteases.
28077	may be involved in protein transport from golgi to cell surface. the zdhhc9-golga7 complex is a palmitoyltransferase specific for hras and nras.
28078	
28079	transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. involved in particular in lens epithelial cell gene regulation and stress responses. may play an important role in lens epithelial to fiber cell terminal differentiation. may play a protective role during stress-induced apoptosis. isoform 2 is a more general and stronger transcriptional coactivator. isoform 2 may also act as an adapter to coordinate pre-mrna splicing. cellular cofactor for lentiviral integration.
28080	muscle contraction.
28081	probably plays a role in facilitating the assembly of multimeric protein complexes inside the er.
28082	
28083	may be involved in the secretory process of mast cells and may play some role in signal transduction pathways.
28084	during embryonic development, some isoforms are essential for proper neuronal differentiation and organization. required for cell polarity; maintenance of apicobasal polarity. plays a critical role at septate junctions in cellular growth control during larval development. the presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
28085	important negative regulator in hematopoiesis and immune systems; may be involved in ending inflammatory responses through its inhibitory functions. inhibits endothelial nf-kappa-b signaling through a camp-dependent pathway. inhibits tnf-alpha- induced expression of endothelial adhesion molecules. involved in the control of fat metabolism and insulin sensitivity.
28086	
28087	
28088	
28089	
28090	
28091	involved in the regulation of structural processes in differentiating and mature neuronal cells (by similarity).
28092	functions in nuclear protein import as nuclear transport receptor. serves as receptor for nuclear localization signals (nls) in cargo substrates. is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (npc) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus (by similarity). mediates the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones.
28093	
28094	probable regulatory protein involved in regulating the response to growth factors.
28095	
28096	probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. may be involved in the uptake of lipoprotein apoe in liver (by similarity).
28097	growth factor active on keratinocytes. possible major paracrine effector of normal epithelial cell proliferation.
28098	probable trna acetyltransferase required for the formation of the modified nucleoside n(4)-acetylcytidine in serine and leucine trnas. binds rna.
28099	required for ribosomal rna processing. associates with u3 small nucleolar rna.
28100	
28101	seems to act exclusively upon threonine residues (by similarity).
28102	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
28103	
28104	
28105	casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. it can phosphorylate a large number of proteins. participates in wnt signaling (by similarity).
28106	
28107	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
28108	
28109	
28110	
28111	
28112	
28113	involved in transport from the endoplasmic reticulum to the golgi apparatus (by similarity).
28114	
28115	
28116	catalyzes the covalent attachment of ubiquitin to other proteins. mediates the selective degradation of short-lived and abnormal proteins. functions in the e6/e6-ap-induced ubiquitination of p53/tp53.
28117	
28118	
28119	may play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. seems to demarcate the juxtaparanodal region of the axo-glial junction.
28120	
28121	
28122	
28123	
28124	
28125	
28126	
28127	
28128	
28129	
28130	
28131	
28132	
28133	orphan receptor.
28134	
28135	
28136	
28137	
28138	
28139	
28140	vital role in development. protein binds to a portion of hunchback (hb) protein that is critical for repression of bithorax complex (bxc) genes. may also function in polycomb group (pcg) repression of hox genes.
28141	
28142	
28143	
28144	
28145	
28146	
28147	
28148	
28149	
28150	
28151	
28152	
28153	
28154	
28155	
28156	
28157	
28158	
28159	
28160	
28161	
28162	
28163	probable transcription factor that may trigger apoptosis by inducing the expression of genes that are critical for cell death.
28164	
28165	
28166	
28167	
28168	
28169	
28170	
28171	
28172	
28173	
28174	
28175	probably involved in the repair of mismatches in dna.
28176	
28177	this is a receptor for vip as well as pacap-38 and -27, the activity of this receptor is mediated by g proteins which activate adenylyl cyclase. can be coupled to phospholipase c.
28178	
28179	
28180	
28181	
28182	
28183	
28184	
28185	
28186	
28187	histone methyltransferase. specifically methylates lys-4 of histone h3, inducing di- and tri-methylation, but not monomethylation. plays an important role in transcriptional activation as a member of an rna polymerase complex.
28188	
28189	
28190	
28191	
28192	
28193	
28194	
28195	acts as a factor that allows the dna to undergo a single round of replication per cell cycle. required for the entry in s phase and for cell division.
28196	
28197	
28198	
28199	
28200	corepressor targeting diverse transcription regulators (by similarity).
28201	
28202	
28203	
28204	responsible for the synthesis of complex-type n-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
28205	
28206	
28207	
28208	
28209	
28210	
28211	
28212	
28213	
28214	the activated kinase acts on a variety of targets. phosphorylates ribosomal protein s6, histone h4 and myelin basic protein.
28215	involved in the presentation of foreign antigens to the immune system.
28216	
28217	
28218	
28219	
28220	
28221	
28222	
28223	
28224	
28225	
28226	
28227	
28228	plays a role in neurogenesis and neuronal migration (by similarity). necessary for correct formation of mitotic spindles and chromosome separation during mitosis. necessary for cytokinesis and cell proliferation.
28229	
28230	
28231	
28232	
28233	
28234	
28235	
28236	
28237	
28238	
28239	
28240	
28241	
28242	
28243	
28244	
28245	
28246	plays an important role in the elongation step of protein synthesis.
28247	
28248	
28249	
28250	
28251	
28252	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
28253	
28254	
28255	
28256	
28257	
28258	
28259	
28260	this protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
28261	
28262	
28263	
28264	
28265	involved in microtubule organization by the microtubule organizing center, the spindle pole body (spb). probably part of the microtubule attachment site at the spb.
28266	
28267	
28268	probable transcription regulator.
28269	
28270	
28271	
28272	
28273	targets myosin phosphatase to the actin cytoskeleton. required for the regulation of the actin cytoskeleton by rhoa and rock1. depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. overexpression of mrip as well as its f- actin-binding region leads to disassembly of stress fibers in neuronal cells.
28274	
28275	clathrin is the major protein of the polyhedral coat of coated pits and vesicles. two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-golgi network.
28276	
28277	
28278	
28279	
28280	not yet known. essential for viability.
28281	
28282	may act as a specific coactivator for the mammalian tefs. may play a role in the development of skeletal muscles.
28283	
28284	
28285	
28286	
28287	
28288	
28289	
28290	
28291	probably involved in mitochondrial protein import. is also required for efficient translocation of pre-pro-alpha-factor. involved in heme regulation of hap1, as a component of the high- molecular-weight (hmc) complex.
28292	
28293	
28294	
28295	
28296	
28297	
28298	
28299	transcriptional repressor.
28300	
28301	may be involved in processing of pneumocyte surfactant precursors.
28302	
28303	gtpase-activating protein for p21-rac and a phorbol ester receptor. may play an important role in neuronal signal- transduction mechanisms.
28304	
28305	
28306	
28307	binds gtp, gdp and gmp.
28308	
28309	
28310	
28311	
28312	
28313	
28314	
28315	
28316	
28317	
28318	
28319	
28320	
28321	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
28322	
28323	
28324	
28325	
28326	functions as an e1 enzyme essential for multisubstrates such as gabarapl1 and atg12. forms intermediate conjugates with gabarapl1 (gabarapl2, gabarap or map1alc3). formation of the final gabarapl1-pe conjugate is essential for autophagy (by similarity).
28327	
28328	
28329	
28330	has antibacterial activity (potential).
28331	
28332	
28333	
28334	
28335	
28336	
28337	
28338	
28339	
28340	
28341	orphan nuclear receptor. binds dna as a monomer to hormone response elements (hre) containing a single core motif half-site preceded by a short a-t-rich sequence. this isomer binds to the consensus sequence 5@#$%&-[at][ta]a[at][cgt]taggtca-3@#$%&.
28342	
28343	
28344	antagonizes the binding of 2-5a (5@#$%&-phosphorylated 2@#$%&,5@#$%&-linked oligoadenylates) by rnase l through direct interaction with rnase l and therefore inhibits its endoribonuclease activity. may play a central role in the regulation of mrna turnover. antagonizes the anti-viral effect of the interferon-regulated 2-5a/rnase l pathway. may act as a chaperone for post-translational events during hiv-1 capsid assembly.
28345	general transcription factor. btf3 can form a stable complex with rna polymerase ii. required for the initiation of transcription.
28346	
28347	
28348	
28349	
28350	
28351	
28352	
28353	
28354	
28355	
28356	
28357	may be involved in transcriptional regulation.
28358	
28359	this protein may be a lipid transport protein in schwann cells.
28360	
28361	type i collagen is a member of group i collagen (fibrillar forming collagen).
28362	
28363	
28364	
28365	
28366	
28367	
28368	
28369	
28370	
28371	
28372	
28373	
28374	
28375	cadherins are calcium dependent cell adhesion proteins. they preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
28376	
28377	
28378	
28379	
28380	
28381	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. l is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes.
28382	
28383	
28384	muscle contraction.
28385	
28386	anti-proliferative protein. modulates transcription regulation mediated by esr1.
28387	
28388	
28389	unknown.
28390	may function as an alternative splicing regulator. regulate its own expression at the level of rna processing. also regulates the splicing of fibronectin and cd45 genes. may act, at least in part, by interaction with other r/s-containing splicing factors.
28391	
28392	
28393	
28394	
28395	
28396	
28397	
28398	may be involved in transcriptional regulation.
28399	
28400	
28401	molecular chaperone; assists the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
28402	
28403	
28404	
28405	rapidly transports ca(2+) during excitation-contraction coupling. ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
28406	
28407	conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (dhea) and androstenedione. catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. involved in sexual development during fetal life and at puberty.
28408	
28409	probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. is not an essential protein. involved in substrate recognition in ubiquitin-dependent degradation.
28410	
28411	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
28412	
28413	
28414	atp-dependent rna helicase which is a subunit of the eif4f complex involved in cap recognition and is required for mrna binding to ribosome. in the current model of translation initiation, eif4a unwinds rna secondary structures in the 5@#$%& untranslated region of mrnas which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
28415	
28416	
28417	
28418	
28419	
28420	single stranded dna-binding protein, with specificity to the sterol regulatory element (sre). involved in sterol-mediated repression.
28421	
28422	
28423	
28424	
28425	
28426	
28427	
28428	
28429	metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
28430	
28431	
28432	may be involved in transcriptional regulation.
28433	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
28434	
28435	
28436	catalyzes the transfer of sulfate to position 4 of non- reducing n-acetylgalactosamine (galnac) residues in both n-glycans and o-glycans. participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. has a higher activity toward carbonic anhydrase vi than toward lutropin. only active against terminal galnacbeta1,galnacbeta. isoform 2, but not isoform 1, is active toward chondroitin.
28437	
28438	
28439	self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
28440	
28441	
28442	
28443	
28444	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
28445	receptor for glucocorticoids (gc). has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (gre) and as a modulator of other transcription factors. affects inflammatory responses, cellular proliferation and differentiation in target tissues. could act as a coactivator for stat5-dependent transcription upon growth hormone (gh) stimulation and could reveal an essential role of hepatic gr in the control of body growth.
28446	
28447	
28448	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
28449	
28450	
28451	
28452	
28453	
28454	implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. may be involved in the regulation of perinuclear intravesicular membrane traffic (by similarity).
28455	
28456	type i collagen is a member of group i collagen (fibrillar forming collagen).
28457	
28458	
28459	reversibly catalyzes the transfer of phosphate between atp and various phosphogens (e.g. creatine phosphate). creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
28460	
28461	
28462	
28463	
28464	
28465	
28466	
28467	may be involved in several stages of intracellular trafficking (by similarity).
28468	
28469	
28470	
28471	integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis.
28472	transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. retinyl esters are storage forms of vitamin a. lrat plays a critical role in vision. it provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.
28473	
28474	
28475	
28476	
28477	may be involved in transcriptional regulation.
28478	
28479	
28480	
28481	
28482	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
28483	
28484	
28485	
28486	plays an essential role in autophagy (by similarity).
28487	
28488	may be involved in transcriptional regulation.
28489	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
28490	
28491	
28492	
28493	required for larval development.
28494	
28495	
28496	
28497	
28498	
28499	
28500	
28501	
28502	
28503	
28504	
28505	part of the insoluble cornified cell envelope (ce) of stratified squamous epithelia.
28506	
28507	
28508	
28509	
28510	has an effect on position-effect variegation.
28511	
28512	
28513	
28514	
28515	potential growth factor receptor protein tyrosine kinase.
28516	
28517	
28518	
28519	
28520	may act as a molecular switch during maturation of the 40s ribosomal subunit in the nucleolus (by similarity).
28521	
28522	
28523	nmda receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine.
28524	
28525	
28526	
28527	
28528	
28529	
28530	
28531	
28532	the ube2v2/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through lys- 63. this type of poly-ubiquitination does not lead to protein degradation by the proteasome. mediates transcriptional activation of target genes. plays a role in the control of progress through the cell cycle and differentiation. plays a role in the error-free dna repair pathway and contributes to the survival of cells after dna damage.
28533	
28534	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. causes the formation of thin, actin-rich surface projections called filopodia.
28535	
28536	
28537	
28538	
28539	
28540	
28541	
28542	
28543	
28544	
28545	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
28546	
28547	
28548	
28549	
28550	
28551	
28552	
28553	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
28554	
28555	
28556	may be involved in several stages of intracellular trafficking (by similarity).
28557	
28558	
28559	
28560	
28561	
28562	l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists. may be involved in the transmission of light information from the retina to the hypothalamus. this receptor binds domoate > kainate > quisqualate > 6-cyano-7-nitroquinoxaline-2,3-dione > l-glutamate = 6,7- dinitroquinoxaline-2,3-dione > dihydrokainate.
28563	
28564	
28565	catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (ipp) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (dmapp) (by similarity).
28566	
28567	
28568	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
28569	
28570	
28571	
28572	
28573	essental for release from glucose repression. it interacts and has functional relationship to the regulatory protein snf4. interacts also with sip1, sip2 and gal83. could phosphorylates cat8.
28574	
28575	
28576	this is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters. may be considered as a novel component of the nf-kappa-b signaling axis responsible for the survival and activation of b-cells after bcr cross-linking (by similarity).
28577	collagen type iii occurs in most soft connective tissues along with type i collagen.
28578	
28579	
28580	
28581	
28582	
28583	
28584	
28585	ribosomal protein p0 is the functional equivalent of e.coli protein l10.
28586	
28587	
28588	
28589	
28590	
28591	
28592	
28593	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
28594	
28595	
28596	
28597	
28598	
28599	
28600	
28601	
28602	
28603	putative atp-dependent protease.
28604	
28605	probably involved in the repair of mismatches in dna.
28606	
28607	
28608	
28609	
28610	
28611	
28612	
28613	
28614	
28615	
28616	
28617	
28618	
28619	
28620	
28621	plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
28622	
28623	
28624	
28625	
28626	
28627	non-catalytic component of the nata n-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with met-ser, met-gly and met-ala. n-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. nat1 anchors ard1 and nat5 to the ribosome and may present the n termini of nascent polypeptides for acetylation.
28628	
28629	
28630	
28631	
28632	
28633	
28634	
28635	
28636	
28637	
28638	
28639	
28640	
28641	
28642	
28643	
28644	
28645	
28646	
28647	
28648	inhibitory regulator of the ras-cyclic amp pathway. stimulates the gtpase of normal but not oncogenic ras p21.
28649	
28650	
28651	
28652	
28653	
28654	
28655	
28656	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
28657	
28658	
28659	
28660	
28661	
28662	
28663	
28664	
28665	
28666	
28667	
28668	required for protein transport from the er to the golgi complex.
28669	
28670	the electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- coa dehydrogenases, glutaryl-coa and sarcosine dehydrogenase. it transfers the electrons to the main mitochondrial respiratory chain via etf-ubiquinone oxidoreductase (etf dehydrogenase).
28671	
28672	f-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. also binds to microtubules (by similarity).
28673	
28674	
28675	
28676	
28677	
28678	
28679	inhibitor of the wnt signaling pathway. down-regulates beta-catenin. probably facilitate the phosphorylation of beta- catenin and apc by gsk3b (by similarity).
28680	
28681	
28682	
28683	
28684	
28685	
28686	
28687	
28688	
28689	
28690	
28691	
28692	
28693	type i collagen is a member of group i collagen (fibrillar forming collagen).
28694	
28695	
28696	
28697	calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic ca(2+) signaling.
28698	
28699	may be important for the development of vital and immunocompetent organs.
28700	
28701	
28702	docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. dok3 is a negative regulator of jnk signaling in b-cells through interaction with inpp5d/ship. may modulate abl function (by similarity).
28703	
28704	
28705	
28706	
28707	
28708	
28709	
28710	
28711	subunit of the integral membrane v0 complex of vacuolar atpase. vacuolar atpase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.
28712	
28713	
28714	
28715	
28716	may play a role in organizing centrosomal microtubules. may act as a tumor suppressor protein. may represent a tumor progression marker.
28717	
28718	
28719	
28720	
28721	
28722	
28723	
28724	
28725	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
28726	
28727	
28728	
28729	
28730	histone h3, along with histone h4, plays a central role in nucleosome formation.
28731	
28732	as-c proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
28733	
28734	
28735	
28736	
28737	probably has no proteolytic activity, since crucial aa characteristic of serine proteases catalytic sites are not conserved.
28738	
28739	
28740	
28741	
28742	
28743	
28744	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
28745	
28746	
28747	
28748	
28749	
28750	
28751	may be able to bind plasminogen at cell surface and enhance plasminogen activation.
28752	
28753	
28754	
28755	
28756	
28757	
28758	
28759	
28760	
28761	hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. contributes to the native pacemaker currents in heart (if) and in neurons (ih). activated by camp, and at 10-100 times higher concentrations, also by cgmp. may mediate responses to sour stimuli.
28762	
28763	
28764	
28765	
28766	
28767	
28768	
28769	
28770	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
28771	binds the poly(a) tail of mrna. may be involved in cytoplasmic regulatory processes of mrna metabolism. can probably bind to cytoplasmic rna sequences other than poly(a) in vivo (by similarity).
28772	
28773	
28774	
28775	
28776	
28777	
28778	
28779	
28780	this is the smallest of the 5 chains of the enzymatic component (coupling factor cf(1)) of the mitochondrial atpase complex (by similarity).
28781	type i collagen is a member of group i collagen (fibrillar forming collagen).
28782	involved in citrate-h+/malate exchange. important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and nad+ for the glycolytic pathway.
28783	
28784	
28785	major high molecular weight protein of desmosomes. involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
28786	may be a dna-binding protein with a regulatory function. may play an important role in cell death and/or in regulation of cell proliferation.
28787	regulates the dimerization of homeodomain protein hnf-1- alpha and enhances its transcriptional activity.
28788	
28789	required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. cooperates with olig1 to establish the pmn domain of the embryonic neural tube. antagonist of v2 interneuron and of nkx2-2-induced v3 interneuron development (by similarity).
28790	
28791	
28792	may be implicated in endosomal trafficking, or microtubule dynamics, or both.
28793	
28794	
28795	
28796	
28797	
28798	
28799	
28800	
28801	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
28802	
28803	
28804	
28805	
28806	
28807	
28808	
28809	in vitro, acts as a receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5).
28810	
28811	
28812	
28813	enhances ar-mediated transactivation. transactivation decreases as the poly-gln length within ar increases.
28814	
28815	
28816	
28817	
28818	
28819	
28820	
28821	
28822	
28823	
28824	
28825	
28826	
28827	
28828	
28829	
28830	
28831	
28832	transcriptional modulator activated by tgf-beta and activin type 1 receptor kinase. smad2 is a receptor-regulated smad (r-smad). may act as a tumor suppressor in colorectal carcinoma.
28833	
28834	
28835	
28836	
28837	
28838	
28839	
28840	cytokine that binds to tnfrsf10a/trailr1, tnfrsf10b/trailr2, tnfrsf10c/trailr3, tnfrsf10d/trailr4 and possibly also to tnfrsf11b/opg. induces apoptosis. its activity may be modulated by binding to the decoy receptors tnfrsf10c/trailr3, tnfrsf10d/trailr4 and tnfrsf11b/opg that cannot induce apoptosis.
28841	
28842	transfers sialic acid from the donor of substrate cmp- sialic acid to galactose containing acceptor substrates.
28843	
28844	
28845	
28846	
28847	
28848	unknown. may have a key functions in the regulation of eye, tooth, brain and craniofacial development.
28849	acts as a regulatory subunit of the 26s proteasome which is involved in the atp-dependent degradation of ubiquitinated proteins.
28850	
28851	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
28852	
28853	involved in cell motility. when hyaluronan binds to hmmr, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. may also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (erk) activity.
28854	
28855	
28856	
28857	
28858	
28859	
28860	nmda receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. mediated by glycine.
28861	may be involved in transcriptional regulation.
28862	may be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.
28863	
28864	
28865	
28866	
28867	
28868	
28869	
28870	
28871	
28872	
28873	
28874	
28875	
28876	
28877	
28878	transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. involved in particular in lens epithelial cell gene regulation and stress responses. may play an important role in lens epithelial to fiber cell terminal differentiation. may play a protective role during stress-induced apoptosis. isoform 2 is a more general and stronger transcriptional coactivator. isoform 2 may also act as an adapter to coordinate pre-mrna splicing. cellular cofactor for lentiviral integration.
28879	
28880	
28881	
28882	
28883	
28884	
28885	serum albumin, the main protein of plasma, has a good binding capacity for water, ca(2+), na(+), k(+), fatty acids, hormones, bilirubin and drugs. its main function is the regulation of the colloidal osmotic pressure of blood.
28886	
28887	
28888	this is an embryonic beta-type chain.
28889	
28890	collagen type iii occurs in most soft connective tissues along with type i collagen.
28891	
28892	
28893	
28894	
28895	putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. preferentially binds to alpha2,6-linked sialic acid. the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. in the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their sh2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. induces apoptosis in acute myeloid leukemia (in vitro).
28896	
28897	
28898	
28899	
28900	
28901	
28902	
28903	
28904	microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. most probably involved in vesicular trafficking processes, in particular endocytosis.
28905	binds vldl and transports it into cells by endocytosis. in order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. binding to reelin induces tyrosine phosphorylation of dab1 and modulation of tau phosphorylation (by similarity).
28906	
28907	may have e3 ubiquitin ligase activity which targets the catalytic subunit of protein phosphatase 2 for degradation.
28908	
28909	
28910	
28911	
28912	this enzyme participates in both the breakdown and synthesis of glucose (by similarity).
28913	
28914	
28915	
28916	
28917	
28918	
28919	
28920	
28921	
28922	promotes the exchange of gdp by gtp. may act as part of a signal transduction system linking the catalytic domains of pam in the lumen of the secretory pathway to cytosolic factors regulating the cytoskeleton and signal transduction pathways.
28923	protein transport. probably involved in vesicular traffic (by similarity).
28924	regulates mitogenic signal transduction by dephosphorylating both thr and tyr residues on map kinases erk1 and erk2.
28925	
28926	
28927	
28928	
28929	
28930	
28931	
28932	
28933	
28934	
28935	
28936	the protein is required for polarized cell growth.
28937	resistance to tetracycline by an active tetracycline efflux. this is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. this protein functions as a metal-tetracycline/h(+) antiporter.
28938	
28939	
28940	
28941	laminin-3 (s-laminin) regulates the formation of motor nerve terminals.
28942	may be involved in transcriptional regulation.
28943	
28944	
28945	
28946	
28947	
28948	
28949	
28950	
28951	inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin a. could play a role during central nervous system development (by similarity).
28952	
28953	
28954	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. mct2 is a high affinity pyruvate transporter.
28955	
28956	
28957	
28958	
28959	
28960	
28961	
28962	
28963	
28964	
28965	
28966	
28967	
28968	
28969	
28970	
28971	
28972	
28973	
28974	may promote functional cell surface expression of olfactory receptors.
28975	
28976	
28977	
28978	
28979	
28980	
28981	
28982	suppresses neurite outgrowth (by similarity).
28983	
28984	
28985	
28986	essential component of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. when overexpressed in cells induces the formation of cytoplasmic annulate lamellae (al) (by similarity).
28987	
28988	motor required for the retrograde transport of golgi vesicles to the endoplasmic reticulum. has a microtubule plus end- directed motility.
28989	
28990	
28991	
28992	can efficiently cleave only isg15 fusions including native isg15 conjugates linked via isopeptide bonds. necessary to maintain a critical cellular balance of isg15-conjugated proteins in both healthy and stressed organisms.
28993	
28994	
28995	
28996	
28997	
28998	
28999	
29000	
29001	binds to type i and ii regulatory subunits of protein kinase a and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
29002	
29003	
29004	
29005	
29006	
29007	
29008	
29009	
29010	catalyzes the reversible synthesis of acetylcholine (ach) from acetyl coa and choline at cholinergic synapses.
29011	
29012	
29013	
29014	
29015	
29016	
29017	
29018	
29019	
29020	3@#$%&-exoribonuclease that has a preference for poly(a) tails of mrnas, thereby efficiently degrading poly(a) tails. exonucleolytic degradation of the poly(a) tail is often the first step in the decay of eukaryotic mrnas and is also used to silence certain maternal mrnas translationally during oocyte maturation and early embryonic development. interacts with both the 3@#$%&-end poly(a) tail and the 5@#$%&-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(a) tails. involved in nonsense-mediated mrna decay, a critical process of selective degradation of mrnas that contain premature stop codons. also involved in degradation of inherently unstable mrnas that contain au-rich elements (ares) in their 3@#$%& untranslated regions, possibly via its interaction with khsrp. probably mediates the removal of poly(a) tails of ares mrnas, which constitutes the first step of destabilization.
29021	
29022	
29023	
29024	isoform 2/truncated isoform may act as an antagonist.
29025	
29026	
29027	
29028	
29029	
29030	implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2a, regulation of mrna trafficking and stability in association with elavl1, and inhibition of acetyltransferases as part of the inhat (inhibitor of histone acetyltransferases) complex.
29031	
29032	
29033	
29034	
29035	type i collagen is a member of group i collagen (fibrillar forming collagen).
29036	component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase. required for axial elements (ae) in meiotic cells and for assembly of the synaptonemal complex. may be important for testis development and male fertility.
29037	
29038	
29039	
29040	
29041	
29042	
29043	
29044	
29045	
29046	
29047	
29048	
29049	
29050	
29051	
29052	
29053	
29054	
29055	
29056	
29057	
29058	binds preferentially single-stranded dna and unwinds double stranded dna.
29059	plays a role in the formation of clathrin-coated invaginations and endocytosis.
29060	
29061	
29062	
29063	
29064	
29065	
29066	
29067	spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. it associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
29068	spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. it associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
29069	
29070	
29071	
29072	
29073	
29074	
29075	
29076	
29077	
29078	
29079	
29080	may be involved in transcriptional regulation.
29081	
29082	
29083	
29084	
29085	
29086	
29087	
29088	
29089	may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. in association with the sfpq-nono heteromer may play a role in nuclear retention of defective rnas.
29090	
29091	
29092	
29093	
29094	cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions (by similarity).
29095	could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
29096	
29097	
29098	
29099	
29100	
29101	
29102	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
29103	
29104	
29105	suppresses neurite outgrowth (by similarity).
29106	
29107	
29108	
29109	
29110	
29111	
29112	may be able to bind plasminogen at cell surface and enhance plasminogen activation.
29113	
29114	
29115	
29116	
29117	
29118	
29119	
29120	
29121	
29122	
29123	has a transcriptional repressor activity by cooperating with epc1. induces apoptosis by activating jun n-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. may function in male germ cell development. has dna-binding activity and preferentially bound to double-stranded dna (by similarity).
29124	
29125	
29126	mediates the nuclear export of aminoacylated trnas. in the nucleus binds to trna and to the gtpase ran in its active gtp- bound form. docking of this trimeric complex to the nuclear pore complex (npc) is mediated through binding to nucleoporins. upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of ran-gtp to ran-gdp (induced by ranbp1 and rangap1, respectively) cause release of the trna from the export receptor. xpot then return to the nuclear compartment and mediate another round of transport. the directionality of nuclear export is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus.
29127	implicated in the early stage of ectopic ossification.
29128	chaperone. isoform 2 may function as an endogenous inhibitory regulator of hsc70 by competing the cochaperones.
29129	
29130	
29131	
29132	
29133	
29134	
29135	
29136	
29137	probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. is not an essential protein. involved in substrate recognition in ubiquitin-dependent degradation.
29138	
29139	
29140	
29141	
29142	
29143	
29144	
29145	
29146	
29147	
29148	required for protein transport to the vacuole. involved in two vesicle trafficking steps to the prevacuolar compartment (pvc), regulating the docking of endosomes and golgi vesicles to the pvc by interacting with pep7/vac1 on the pvc membrane and promoting snare complex formation.
29149	
29150	
29151	
29152	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
29153	
29154	
29155	
29156	
29157	
29158	may play a role in the apoptotic pathway or cell-cycle regulation induced by p53 after dna damage.
29159	has an important function as a repair enzyme for proteins that have been inactivated by oxidation. catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
29160	
29161	
29162	
29163	
29164	
29165	
29166	
29167	
29168	
29169	
29170	
29171	
29172	
29173	
29174	
29175	
29176	
29177	
29178	
29179	probable transcription regulator.
29180	
29181	involved in transcription regulation.
29182	
29183	
29184	
29185	
29186	
29187	
29188	
29189	
29190	may act as a tumor suppressor.
29191	
29192	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
29193	
29194	
29195	
29196	
29197	
29198	
29199	
29200	
29201	
29202	
29203	transcriptional regulator involved in development.
29204	factor xiii is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
29205	
29206	
29207	
29208	
29209	
29210	
29211	
29212	
29213	
29214	
29215	signal-transducing molecule. the receptor systems for il6, lif, osm, cntf, il11, ctf1 and bsf3 can utilize gp130 for initiating signal transmission. binds to il6/il6r (alpha chain) complex, resulting in the formation of high-affinity il6 binding sites, and transduces the signal. does not bind il6. may have a role in embryonic development (by similarity).
29216	involved in the repair of mismatches in dna.
29217	
29218	
29219	
29220	binds to the purine-rich region in htlv-i ltr.
29221	
29222	
29223	
29224	may function as an adapter molecule that regulates traf3-mediated jnk activation (by similarity).
29225	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
29226	
29227	
29228	ubiquitous transcription factor required for a diverse set of processes. it is a component of the ccr4 complex involved in the control of gene expression (by similarity).
29229	involved in the degradation of prenylated proteins. cleaves the thioether bond of prenyl-l-cysteines, such as farnesylcysteine and geranylgeranylcysteine.
29230	
29231	
29232	
29233	isoform neural may associate with cadn and participate in the transmission of developmental information. can associate with alpha-catenin. isoform cytoplasmic accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. arm and abl proteins function cooperatively at adherens junctions in both the cns and epidermis.
29234	
29235	
29236	
29237	
29238	
29239	
29240	
29241	component of the cornified envelope of keratinocytes. may link the cornified envelope to desmosomes and intermediate filaments.
29242	
29243	
29244	converts lysophosphatidic acid (lpa) into phosphatidic acid by incorporating acyl moiety at the 2 position (by similarity).
29245	
29246	
29247	
29248	
29249	
29250	
29251	
29252	
29253	
29254	binds pre-mrna and nucleates the assembly of 40s hnrnp particles. single hnrpc tetramers bind 230-240 nucleotides. trimers of hnrpc tetramers bind 700 nucleotides. may play a role in the early steps of spliceosome assembly and pre-mrna splicing. interacts with poly-u tracts in the 3@#$%& or 5@#$%& untranslated regions of mrna and modulates the stability and the level of translation of bound mrna molecules.
29255	
29256	
29257	
29258	
29259	
29260	
29261	
29262	
29263	
29264	among other substrates, acts on ysca (pep4) to activate it by processing its pro-peptide.
29265	
29266	
29267	may be involved in transcriptional regulation.
29268	
29269	
29270	
29271	gamma chains make up the fetal hemoglobin f, in combination with alpha chains.
29272	
29273	
29274	
29275	
29276	
29277	
29278	likely to play a regulatory role in the development of the ventral forebrain. may play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (by similarity).
29279	
29280	
29281	type ii regulatory chains mediate membrane association by binding to anchoring proteins, including the map2 kinase.
29282	
29283	involved in recruiting unphosphorylated forms of smad2/smad3 to the tgf-beta receptor by controlling their subcellular localization and by interacting and colocalizing with the tgf-beta receptor. phosphorylation of smad2/smad3 induces dissociation from zfyve9 and formation of smad2/smad4 complexes and nuclear translocation.
29284	
29285	
29286	
29287	
29288	
29289	the protein is required for polarized cell growth.
29290	
29291	
29292	
29293	has a strict specificity for hydrolysis of asparaginyl bonds. can also cleave aspartyl bonds slowly, especially under acidic conditions. may be involved in the processing of proteins for mhc class ii antigen presentation in the lysosomal/endosomal system.
29294	
29295	
29296	
29297	
29298	
29299	
29300	
29301	
29302	
29303	
29304	
29305	
29306	
29307	
29308	
29309	
29310	
29311	
29312	adapter molecule functioning in neural development. may regulate siah1 activity (by similarity).
29313	
29314	
29315	poly[adp-ribose] polymerase modifies various nuclear proteins by poly(adp-ribosyl)ation. the modification is dependent on dna and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from dna damage.
29316	may stabilize hdl (high density lipoprotein) structure by its association with lipids, and affect the hdl metabolism.
29317	may be involved in transcriptional regulation.
29318	
29319	
29320	
29321	may regulate vesicle trafficking and modulate the subcellular distribution of slc2a4/glut4-vesicles. has parp activity and can modify terf1, and thereby contribute to the regulation of telomere length.
29322	
29323	unknown.
29324	
29325	corepressor targeting diverse transcription regulators (by similarity).
29326	
29327	inhibitory regulator of the ras-cyclic amp pathway. binds inositol tetrakisphosphate (ip4).
29328	
29329	
29330	
29331	
29332	
29333	
29334	
29335	
29336	
29337	
29338	
29339	
29340	
29341	
29342	
29343	
29344	
29345	
29346	
29347	
29348	ubiquitin ligase protein which is a component of the n- end rule pathway. recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the n-end rule, leading to their ubiquitination and subsequent degradation.
29349	
29350	
29351	
29352	
29353	
29354	
29355	
29356	
29357	
29358	
29359	
29360	
29361	catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.
29362	
29363	has some calmodulin-like activity with respect to enzyme activation and growth regulation. binds two calcium ions.
29364	
29365	
29366	may be involved in transcriptional regulation.
29367	
29368	
29369	the mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, zp1, zp2, zp3, and zp4. zp4 may act as a sperm receptor.
29370	
29371	
29372	
29373	
29374	
29375	
29376	
29377	
29378	involved in stress resistance and actin organization.
29379	
29380	
29381	
29382	
29383	
29384	
29385	
29386	
29387	
29388	conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. has a wide substrate specificity.
29389	
29390	
29391	
29392	
29393	
29394	transporter involved in macrophage lipid homeostasis. is an active component of the macrophage lipid export complex. could also be involved in intracellular lipid transport processes. the role in cellular lipid homeostasis may not be limited to macrophages.
29395	rapidly transports ca(2+) during excitation-contraction coupling. ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
29396	
29397	
29398	
29399	
29400	
29401	
29402	
29403	
29404	
29405	
29406	
29407	
29408	
29409	
29410	guanine nucleotide exchange factor that potentially links pathways that signal through rac1, rhoa and cdc42. catalyzes guanine nucleotide exchange on rhoa and cdc42 and interacts specifically with the gtp-bound form of rac1, suggesting that it functions as an effector of rac1. may also participate in axonal transport in the brain. becomes activated and highly tumorigenic by truncation of the n-terminus (by similarity).
29411	
29412	activates the jun n-terminal pathway.
29413	
29414	
29415	
29416	
29417	
29418	may play a structural role at sites of cell adhesion in maintaining cell shape and motility. in addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. may be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
29419	methylates the carboxyl group of the c-terminal leucine residue of protein phosphatase 2a catalytic subunits (ppp2ca) to form alpha-leucine ester residues (by similarity).
29420	binds specifically to the 3@#$%&-terminal u-tract of u6 snrna.
29421	
29422	anti-proliferative protein that interacts with the erbb- 2 receptor tyrosine kinase. may physically and/or functionally interact with protein-tyrosine kinase receptors.
29423	
29424	
29425	
29426	
29427	binds to the pu-box, a purine-rich dna sequence (5@#$%&- gaggaa-3@#$%&) that can act as a lymphoid-specific enhancer. this protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or b- cells. also binds rna and may modulate pre-mrna splicing (by similarity).
29428	
29429	
29430	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
29431	
29432	
29433	
29434	
29435	
29436	binds dna with high affinity. may also be involved in protein-protein interactions (by similarity).
29437	
29438	involved in vesicular protein trafficking.
29439	
29440	
29441	controls reversibly actin polymerization and depolymerization in a ph-sensitive manner. it has the ability to bind g- and f-actin in a 1:1 ratio of cofilin to actin. it is the major component of intranuclear and cytoplasmic actin rods.
29442	
29443	involved in cdc48-dependent protein degradation through the ubiquitin/proteasome pathway. direct or indirect positive regulator of glc7 activity.
29444	
29445	
29446	
29447	
29448	
29449	
29450	
29451	
29452	
29453	
29454	
29455	
29456	
29457	
29458	
29459	
29460	
29461	
29462	may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. in association with the sfpq-nono heteromer may play a role in nuclear retention of defective rnas.
29463	
29464	
29465	
29466	
29467	
29468	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
29469	
29470	
29471	
29472	essential component of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. when overexpressed in cells induces the formation of cytoplasmic annulate lamellae (al) (by similarity).
29473	
29474	
29475	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
29476	
29477	
29478	
29479	
29480	probable transcription regulator.
29481	required for the relief of p53-dependent checkpoint mediated cell cycle arrest. binds to and dephosphorylates ser-15 of tp53 and ser-345 of chek1 which contributes to the functional inactivation of these proteins.
29482	
29483	
29484	
29485	
29486	catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
29487	
29488	
29489	
29490	important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex gpib-ix-v. also acts as a chaperone for coagulation factor viii, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
29491	
29492	
29493	
29494	
29495	
29496	
29497	
29498	
29499	
29500	
29501	catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a thr-glu-tyr sequence located in map kinases. activates the erk1 and erk2 map kinases.
29502	
29503	binds to gtp-bound form of rho and to profilin. acts in a rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. it is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics (by similarity).
29504	
29505	
29506	
29507	
29508	
29509	probably involved in connections of major cytoskeletal structures to the plasma membrane.
29510	
29511	
29512	
29513	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
29514	
29515	
29516	
29517	
29518	
29519	
29520	
29521	
29522	complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. also mediates erythropoiesis in vitro; but, unlike il-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. known to act on mmp-1, mmp-2, mmp-3, mmp-7, mmp-8, mmp-9, mmp-10, mmp-11, mmp-12, mmp-13 and mmp-16. does not act on mmp-14.
29523	
29524	
29525	
29526	
29527	
29528	
29529	
29530	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
29531	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. srp9 together with srp14 and the alu portion of the srp rna, constitutes the elongation arrest domain of srp. the complex of srp9 and srp14 is required for srp rna binding.
29532	
29533	
29534	
29535	
29536	
29537	
29538	
29539	proton-linked monocarboxylate transporter. catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (by similarity).
29540	
29541	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
29542	
29543	
29544	
29545	
29546	
29547	probably involved in a neuron-specific signal transduction.
29548	
29549	
29550	
29551	calcium-binding protein required for t-cell receptor-, fas-, and glucocorticoid-induced cell death. may mediate ca(2+)- regulated signals along the death pathway (by similarity).
29552	
29553	
29554	anchoring protein that mediates the subcellular compartmentation of protein kinase a (pka) and protein kinase c (pkc).
29555	
29556	transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. crucial in the maintenance of the thyroid differentiation phenotype. may play a role in lung development and surfactant homeostasis.
29557	
29558	
29559	acts as a negative coregulator for lim homeodomain transcription factors. via the recruitment of the sin3a/histone deacetylase corepressor complex.
29560	
29561	
29562	
29563	
29564	
29565	
29566	required for glial-neuronal cell interactions at the ventral midline which are necessary for the proper elaboration of commissures in the embryonic cns.
29567	this protein promotes the gtp-dependent binding of aminoacyl-trna to the a-site of ribosomes during protein biosynthesis.
29568	
29569	
29570	
29571	
29572	implicated in the control of cell fate decisions during development.
29573	
29574	
29575	
29576	
29577	
29578	
29579	
29580	
29581	
29582	voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. the isoform alpha-1b gives rise to n-type calcium currents. n-type calcium channels belong to the @#$%!high-voltage activated@#$%! (hva) group and are blocked by omega-conotoxin-gvia (omega-ctx-gvia) and by omega-agatoxin- iiia (omega-aga-iiia). they are however insensitive to dihydropyridines (dhp), and omega-agatoxin-iva (omega-aga-iva). calcium channels containing alpha-1b subunit may play a role in directed migration of immature neurons.
29583	
29584	
29585	
29586	
29587	
29588	
29589	
29590	integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis.
29591	
29592	may transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid of n-linked oligosaccharides of glycoproteins and glycolipids. it can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.
29593	
29594	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
29595	
29596	
29597	
29598	
29599	
29600	
29601	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
29602	
29603	
29604	
29605	
29606	
29607	
29608	
29609	kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.
29610	
29611	
29612	
29613	
29614	
29615	
29616	
29617	
29618	
29619	
29620	
29621	
29622	essential component of the pam complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an atp-dependent manner. recruits mitochondrial hsp70 to drive protein translocation into the matrix using atp as an energy source.
29623	
29624	
29625	
29626	
29627	
29628	
29629	
29630	may be involved in transcriptional regulation.
29631	
29632	
29633	
29634	
29635	catalyzes the covalent attachment of ubiquitin to other proteins. mediates the selective degradation of short-lived and abnormal proteins.
29636	
29637	
29638	function in general translation initiation by promoting the binding of the formylmethionine-trna to ribosomes. seems to function along with eif-2.
29639	may contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.
29640	
29641	
29642	
29643	
29644	
29645	
29646	
29647	
29648	
29649	
29650	
29651	
29652	
29653	may belong to a complex displaying n-terminal acetyltransferase activity (by similarity).
29654	
29655	
29656	
29657	
29658	
29659	
29660	
29661	
29662	
29663	
29664	inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin a. could play a role during central nervous system development.
29665	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
29666	
29667	
29668	
29669	
29670	
29671	
29672	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression.
29673	
29674	
29675	
29676	also exhibits a dipeptidyl-peptidase iv type activity. in vitro, cleaves gly-pro-amc.
29677	calcium-dependent mitochondrial aspartate and glutamate carrier. may have a function in the urea cycle.
29678	
29679	
29680	
29681	
29682	
29683	modulates the activation of caspases during apoptosis. is a substrate for orgyia pseudotsugata multicapsid polyhedrosis virus (opmnpv) iap-mediated ubiquitination.
29684	modulates the activation of caspases during apoptosis. is a substrate for orgyia pseudotsugata multicapsid polyhedrosis virus (opmnpv) iap-mediated ubiquitination.
29685	potential transcription factor. may mediate some of the neuroprotective peptide vip-associated effects involving normal growth and cancer proliferation.
29686	
29687	
29688	
29689	
29690	
29691	
29692	major high molecular weight protein of desmosomes. involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
29693	eif-2 functions in the early steps of protein synthesis by forming a ternary complex with gtp and initiator trna. this complex binds to a 40s ribosomal subunit, followed by mrna binding to form a 43s preinitiation complex. junction of the 60s ribosomal subunit to form the 80s initiation complex is preceded by hydrolysis of the gtp bound to eif-2 and release of an eif-2-gdp binary complex. in order for eif-2 to recycle and catalyze another round of initiation, the gdp bound to eif-2 must exchange with gtp by way of a reaction catalyzed by eif-2b.
29694	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
29695	
29696	
29697	
29698	
29699	
29700	
29701	
29702	
29703	binds to f-actin in a calcium-independent manner. has no direct effect on actin depolymerization.
29704	
29705	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
29706	
29707	
29708	
29709	
29710	
29711	
29712	
29713	
29714	
29715	
29716	
29717	
29718	may function as signal-transmitting receptor.
29719	
29720	
29721	
29722	functions as a sorting receptor in the golgi compartment and as a clearance receptor on the cell surface. required for protein transport from the golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (m6pr). also required for protein transport from the golgi apparatus to the endosomes. promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of bdnf (probdnf) and ngfb (prongfb). also acts as a receptor for neurotensin. may promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular lpl. probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter slc2a4/glut4 (glut4 storage vesicles, or gsvs). these vesicles provide a stable pool of slc2a4 and confer increased responsiveness to insulin. may also mediate transport from the endoplasmic reticulum to the golgi.
29723	
29724	probably plays a role in anchoring the complex to other cellular components.
29725	
29726	
29727	
29728	orphan receptor.
29729	
29730	
29731	
29732	plays a role in cytoplasmic trafficking of rna. binds to the cis-acting response element, a2re.
29733	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (by similarity). this protein may be involved in maturation and/or post-transcriptional regulation of mrna. may play a role in control of cell cycle progression. may have tumor suppressor function. regulates dna topoisomerase ii binding protein (topbp1) for the dna damage response. plays an essential role in extraembryonic development.
29734	
29735	
29736	
29737	
29738	cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. also permeable for li(+) and k(+). generates a biphasic current with a fast inactivating and a slow sustained phase. heteromeric channel assembly seems to modulate.
29739	
29740	functions as a histone acetyltransferase (hat) to promote transcriptional activation. has significant histone acetyltransferase activity with core histones (h3 and h4), and also with nucleosome core particles. inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein e1a.
29741	
29742	
29743	promotes guanine-nucleotide exchange on arf1 and arf3. promotes the activation of arf1/arf3 through replacement of gdp with gtp.
29744	
29745	mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.
29746	
29747	
29748	
29749	
29750	
29751	
29752	
29753	transcriptional activator which recognizes variations of the palindromic sequence 5@#$%&-attcccnngggaatt-3@#$%& (by similarity).
29754	
29755	
29756	
29757	
29758	
29759	
29760	
29761	
29762	
29763	
29764	
29765	
29766	probably involved in nervous system development and function.
29767	
29768	
29769	binds opioids in the presence of acidic lipids; probably involved in cell contact.
29770	
29771	
29772	
29773	
29774	e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (by similarity).
29775	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
29776	
29777	
29778	
29779	
29780	
29781	
29782	
29783	
29784	
29785	
29786	
29787	
29788	
29789	
29790	
29791	plays a role in the sorting and targeting of vacuolar proteases.
29792	
29793	
29794	
29795	
29796	transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. cbf binds to the core site, 5@#$%&- pygpyggt-3@#$%&, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, t-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(i) collagen, lck, il-3 and gm-csf promoters (by similarity). inhibits myst4-dependent transcriptional activation.
29797	
29798	
29799	
29800	
29801	
29802	
29803	
29804	
29805	
29806	
29807	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
29808	component c2 which is part of the classical pathway of the complement system is cleaved by activated factor c1 into two fragments: c2b and c2a. c2a, a serine protease, then combines with complement factor 4b to generate the c3 or c5 convertase.
29809	component c2 which is part of the classical pathway of the complement system is cleaved by activated factor c1 into two fragments: c2b and c2a. c2a, a serine protease, then combines with complement factor 4b to generate the c3 or c5 convertase.
29810	
29811	
29812	
29813	
29814	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
29815	
29816	
29817	
29818	receptor for neurturin. mediates the nrtn-induced autophosphorylation and activation of the ret receptor. also able to mediate gdnf signaling through the ret tyrosine kinase receptor.
29819	
29820	
29821	
29822	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
29823	
29824	
29825	
29826	
29827	
29828	
29829	
29830	
29831	
29832	
29833	
29834	
29835	
29836	
29837	
29838	
29839	
29840	
29841	forms a channel through the mitochondrial outer membrane and also the plasma membrane. the channel allows diffusion of small hydrophilic molecules; it adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mv. the open state has a weak anion selectivity whereas the closed state is cation-selective. may participate in the formation of the permeability transition pore complex (ptpc) responsible for the release of mitochondrial products that triggers apoptosis.
29842	
29843	
29844	
29845	identifies cytotoxic/suppressor t-cells that interact with mhc class i bearing targets. cd8 is thought to play a role in the process of t-cell mediated killing. cd8 alpha chains binds to class i mhc molecules alpha-3 domains.
29846	
29847	
29848	
29849	may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (by similarity).
29850	
29851	activates erythroid-specific, globin gene expression.
29852	
29853	involved in transcriptional regulation as an activator.
29854	
29855	
29856	
29857	
29858	
29859	
29860	terminal component of the liver microsomal stearyl-coa desaturase system, that utilizes o(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-coa substrates including palmitoyl-coa and stearoyl-coa.
29861	
29862	
29863	part of the nucleoporin complex; required for correct nuclear pore assembly.
29864	
29865	
29866	
29867	
29868	
29869	
29870	
29871	
29872	component of the nua4 histone acetyltransferase (hat) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone h4 and h2a. this modification may both alter nucleosome - dna interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. this complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and dna repair. the nua4 complex atpase and helicase activities seem to be, at least in part, contributed by the association of ruvbl1 and ruvbl2 with ep400. nua4 may also play a direct role in dna repair when directly recruited to sites of dna damage. also component of the msin3a complex which acts to repress transcription by deacetylation of nucleosomal histones.
29873	
29874	
29875	
29876	
29877	
29878	
29879	
29880	
29881	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
29882	
29883	
29884	
29885	binds to scaffold/matrix attachment region (s/mar) dna and forms a molecular assembly point to allow the formation of a @#$%&transcriptosomal@#$%& complex (consisting of sr proteins and rna polymerase ii) coupling transcription and rna processing (by similarity). can function as an estrogen receptor corepressor and can also bind to the hsp27 promoter and decrease its transcription. can inhibit cell proliferation.
29886	
29887	
29888	type i collagen is a member of group i collagen (fibrillar forming collagen).
29889	
29890	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
29891	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration (by similarity). in hearing it may play a role in the regulation of actin polymerization in hair cells.
29892	
29893	
29894	
29895	
29896	
29897	
29898	
29899	
29900	
29901	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. srp9 together with srp14 and the alu portion of the srp rna, constitutes the elongation arrest domain of srp. the complex of srp9 and srp14 is required for srp rna binding.
29902	
29903	hydrolyzes n(g),n(g)-dimethyl-l-arginine (adma) and n(g)-monomethyl-l-arginine (mma) which act as inhibitors of nos. has therefore a role in nitric oxide generation.
29904	sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate (by similarity).
29905	
29906	
29907	
29908	
29909	induces apoptosis. interacts with viral and cellular anti-apoptosis proteins. can overcome the suppressors bcl-2 and bcl-xl, although high levels of bcl-xl expression will inhibit apoptosis. may function as a tumor suppressor.
29910	
29911	
29912	
29913	
29914	calcium-binding protein required for t-cell receptor-, fas-, and glucocorticoid-induced cell death. may mediate ca(2+)- regulated signals along the death pathway (by similarity).
29915	
29916	
29917	
29918	
29919	
29920	
29921	
29922	
29923	
29924	
29925	
29926	
29927	
29928	not known; binds gtp and exhibits intrinsic gtpase activity (by similarity).
29929	
29930	
29931	
29932	
29933	
29934	
29935	
29936	
29937	
29938	
29939	
29940	
29941	
29942	binds to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation. inhibits the phosphorylation of nucleosomal histones h3 and h2a by rps6ka5/msk1 and rps6ka3/rsk2 (by similarity).
29943	
29944	
29945	
29946	component of the sin3-repressing complex. enhances the ability of sin3-hdac1-mediated transcriptional repression. when tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins.
29947	
29948	
29949	
29950	
29951	
29952	
29953	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
29954	
29955	tumor-associated antigen.
29956	
29957	
29958	
29959	
29960	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
29961	this protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
29962	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
29963	isoform b is a putative inhibitory receptor. isoform a may be its activating counterpart.
29964	isoform b is a putative inhibitory receptor. isoform a may be its activating counterpart.
29965	
29966	
29967	
29968	
29969	
29970	
29971	
29972	
29973	
29974	
29975	
29976	
29977	
29978	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
29979	
29980	
29981	
29982	
29983	
29984	
29985	
29986	
29987	
29988	
29989	
29990	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
29991	could regulate beta-glucan synthesis. overexpression provides resistance to hm-1 killer toxin.
29992	
29993	
29994	
29995	
29996	
29997	
29998	
29999	binds to splice sites in pre-mrna and regulates splice site selection. binds and stabilizes cytoplasmic mrna. contributes to the regulation of translation by modulating the interaction between the mrna and eukaryotic initiation factors (by similarity). binds to promoters that contain a y-box (5@#$%&- ctgattggccaa-3@#$%&), such as hla class ii genes. regulates the transcription of numerous genes. promotes separation of dna strands that contain mismatches or are modified by cisplatin. has endonucleolytic activity and can introduce nicks or breaks into double-stranded dna (in vitro). may play a role in dna repair.
30000	
30001	
30002	
30003	
30004	
30005	
30006	required for protein transport from the er to the golgi complex.
30007	polymerase alpha in a complex with dna primase is a replicative polymerase.
30008	
30009	
30010	regulates negatively fas-induced apoptosis and ngfr- mediated pro-apoptotic signaling.
30011	
30012	
30013	as a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. recruits pip5k1c to focal adhesion plaques and strongly activates its kinase activity (by similarity).
30014	forms a channel through the mitochondrial outer membrane and also the plasma membrane. the channel allows diffusion of small hydrophilic molecules; it adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mv. the open state has a weak anion selectivity whereas the closed state is cation-selective. may participate in the formation of the permeability transition pore complex (ptpc) responsible for the release of mitochondrial products that triggers apoptosis.
30015	
30016	
30017	
30018	
30019	
30020	
30021	
30022	
30023	complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. also mediates erythropoiesis in vitro; but, unlike il-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. known to act on mmp-1, mmp-2, mmp-3, mmp-7, mmp-8, mmp-9, mmp-10, mmp-11, mmp-12, mmp-13 and mmp-16. does not act on mmp-14.
30024	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
30025	
30026	
30027	
30028	
30029	
30030	ubiquitous transcription factor required for a diverse set of processes. it is a component of the ccr4 complex involved in the control of gene expression (by similarity).
30031	
30032	
30033	maintains high levels of reduced glutathione in the cytosol.
30034	thought to stabilize the calcium channel in an inactivated (closed) state (by similarity).
30035	
30036	as-c proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
30037	
30038	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
30039	
30040	
30041	this is a non-secretory ribonuclease. it is a pyrimidine specific nuclease with a slight preference for u. cytotoxin and helminthotoxin. selectively chemotactic for dendritic cells. possesses a wide variety of biological activities.
30042	
30043	
30044	
30045	
30046	
30047	catalyzes the covalent attachment of ubiquitin to other proteins (by similarity).
30048	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity. this subunit is involved in antigen processing to generate class i binding peptides.
30049	
30050	
30051	
30052	
30053	
30054	signal-transducing molecule. may have a common pathway with il6st. the soluble form inhibits the biological activity of lif by blocking its binding to receptors on target cells.
30055	
30056	
30057	
30058	may be involved in transcriptional regulation.
30059	
30060	
30061	
30062	
30063	
30064	
30065	
30066	
30067	
30068	the long isoform may play a role in neural and glial cell adhesion in the developing embryo. the short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. vital for embryonic development. essential for septate junctions. septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. required for the blood-brain barrier formation.
30069	
30070	
30071	
30072	
30073	
30074	receptor for glutamate. l-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. the postsynaptic actions of glu are mediated by a variety of receptors that are named according to their selective agonists. this receptor binds ampa(quisqualate) > glutamate > kainate.
30075	
30076	
30077	
30078	
30079	
30080	
30081	
30082	
30083	
30084	may play a role in organizing the actin cytoskeleton of the brain cells.
30085	
30086	
30087	
30088	
30089	
30090	
30091	
30092	
30093	
30094	subunit of the splicing factor sf3b required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex. belongs also to the minor u12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mrna intron.
30095	
30096	
30097	
30098	not known. may bind to chromatin.
30099	
30100	
30101	
30102	
30103	
30104	may be involved in a redox-related process (potential).
30105	
30106	
30107	
30108	
30109	
30110	
30111	
30112	involved in cytokinesis (potential).
30113	
30114	
30115	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. the n-terminus interacts with and regulates xpd whereas an intact c- terminus is required for a successful escape of rnap ii form the promoter.
30116	
30117	
30118	may play an important role in palate formation.
30119	
30120	
30121	
30122	
30123	
30124	
30125	
30126	
30127	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. binds the 7s rna only in presence of srp68. this ribonucleoprotein complex might interact directly with the docking protein in the er membrane and possibly participate in the elongation arrest function.
30128	
30129	
30130	
30131	
30132	
30133	
30134	
30135	
30136	
30137	
30138	
30139	
30140	
30141	transcriptional regulator that acts as repressor or activator. binds, in-vitro, to nf-e2 binding sites. play important roles in coordinating transcription activation and repression by mafk.
30142	
30143	
30144	
30145	
30146	
30147	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
30148	
30149	
30150	not known. binds calcium.
30151	
30152	
30153	
30154	
30155	
30156	
30157	
30158	
30159	
30160	
30161	
30162	
30163	ligand for cd2. might facilitate interaction between activated lymphocytes. probably involved in regulating t-cell activation.
30164	orphan nuclear receptor.
30165	
30166	actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
30167	
30168	recognizes and binds the 7-methylguanosine-containing mrna cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mrnas secondary structures.
30169	
30170	
30171	
30172	
30173	
30174	
30175	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
30176	
30177	
30178	unknown. has no cmp-n-acetylneuraminic acid (cmp-neu5ac) hydroxylase activity.
30179	
30180	
30181	
30182	might possibly play a role in rna metabolism.
30183	
30184	
30185	
30186	
30187	
30188	
30189	
30190	
30191	
30192	
30193	
30194	
30195	
30196	
30197	
30198	
30199	
30200	
30201	
30202	
30203	
30204	
30205	
30206	
30207	
30208	
30209	
30210	
30211	
30212	
30213	
30214	
30215	also exhibits a dipeptidyl-peptidase iv type activity. in vitro, cleaves gly-pro-amc.
30216	
30217	possible dna-binding subunit of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.
30218	
30219	
30220	
30221	
30222	
30223	
30224	
30225	
30226	
30227	
30228	
30229	
30230	
30231	
30232	
30233	may be involved in transcriptional regulation.
30234	binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
30235	
30236	
30237	
30238	may be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.
30239	
30240	
30241	
30242	
30243	
30244	
30245	anti-proliferative protein inhibits cell cycle progression from the g0/g1 to s phases.
30246	may be involved in transcriptional regulation.
30247	
30248	
30249	
30250	
30251	
30252	
30253	
30254	
30255	
30256	
30257	
30258	
30259	
30260	
30261	
30262	
30263	
30264	may function as a positive regulator for mannosylphosphate transferase. is required to mediate mannosylphosphate transfer in both the core and outer chain portions of n-linked oligosaccharides.
30265	
30266	
30267	
30268	
30269	
30270	
30271	
30272	
30273	
30274	
30275	tyrosine kinase, that after binding to cdc42, inhibits both its intrinsic and stimulated gtpase activity.
30276	
30277	
30278	
30279	
30280	putative odorant receptor.
30281	
30282	
30283	
30284	
30285	mediates the vitamin k-dependent carboxylation of glutamate residues to calcium binding gamma-carboxyglutamate (gla) residues with the concomitant convertion of the reduced hydroquinone form of vitamin k to vitamin k epoxide.
30286	
30287	
30288	
30289	
30290	
30291	
30292	
30293	
30294	
30295	
30296	
30297	
30298	
30299	
30300	
30301	in vitro, acts as a receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5).
30302	
30303	
30304	
30305	
30306	
30307	
30308	
30309	
30310	
30311	
30312	
30313	
30314	
30315	
30316	
30317	
30318	acts as an adapter protein of the fyn and sh2-domain- containing leukocyte protein-76 (slp76) signaling cascades in t cells. modulates the expression of interleukin-2 (il-2).
30319	may be involved in transcriptional regulation.
30320	may be involved in transcriptional regulation.
30321	
30322	the function of subunit 3 is not clear.
30323	
30324	may be involved in transcriptional regulation.
30325	
30326	
30327	
30328	transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
30329	
30330	
30331	
30332	transcriptional corepressor. may specifically inhibit gene expression when recruited to promoter regions by sequence specific dna-binding proteins such as bcl6 and mllt3. this repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.
30333	
30334	
30335	
30336	may be involved in protein trafficking from the plasma membrane to the early endosome (ee) as well as in homotypic fusion of endocytic organelles. mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.
30337	
30338	
30339	
30340	
30341	
30342	plays a general role in the hierarchies of gene expression leading to metamorphosis.
30343	stimulates gdp/gtp exchange reaction of a group of small gtp-binding proteins (g proteins) including rap1a/rap1b, rhoa, rhob and kras, by stimulating the dissociation of gdp from and the subsequent binding of gtp to each small g protein.
30344	
30345	
30346	
30347	
30348	
30349	may play a role in testis development (by similarity).
30350	
30351	
30352	
30353	
30354	acts as a transcriptional repressor. binds to e-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes (by similarity).
30355	
30356	
30357	
30358	major component of the transverse filaments of synaptonemal complexes (scs), formed between homologous chromosomes during meiotic prophase.
30359	
30360	
30361	
30362	
30363	
30364	
30365	
30366	
30367	
30368	
30369	transcription factor that regulates cit2 gene expression. binds to two identical sites oriented as inverted repeats 28 bp apart in a regulatory upstream activation sequence element (uasr) in the cit2 promoter. the core binding site is 5@#$%&- ggtcac-3@#$%&.
30370	dna-binding protein that binds to the 5@#$%&-aata[ct]-3@#$%& core sequence. probably acts as a transcription regulator. represses the cytomegalovirus enhancer. overexpression leads to induction of smooth muscle marker genes, suggesting that it may act as a regulator of smooth muscle cell differentiation and proliferation. may be involved in lipid stores.
30371	
30372	
30373	
30374	
30375	assembly protein recruiting clathrin and adaptor protein complex 2 (ap2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. involved in ap2-dependent clathrin-mediated endocytosis at the neuromuscular junction.
30376	
30377	critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+).
30378	functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (nls) in cargo substrates, or by acting as autonomous nuclear transport receptor. acting autonomously, serves itself as nls receptor. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran-dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. mediates autonomously the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in association with ipo7 mediates the nuclear import of h1 histone. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones.
30379	
30380	ribosomal protein p0 is the functional equivalent of e.coli protein l10.
30381	
30382	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.
30383	
30384	catalyzes the covalent attachment of ubiquitin to other proteins (by similarity).
30385	
30386	
30387	
30388	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
30389	
30390	
30391	
30392	may be involved in tissue-specific alternative rna processing events.
30393	
30394	may play a role in a signaling pathway regulating nuclear functions of cell proliferaration. phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
30395	
30396	
30397	probably involved in the repair of mismatches in dna.
30398	
30399	
30400	probable collagen protein.
30401	
30402	
30403	
30404	
30405	
30406	
30407	
30408	implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2a, regulation of mrna trafficking and stability in association with elavl1, and inhibition of acetyltransferases as part of the inhat (inhibitor of histone acetyltransferases) complex.
30409	
30410	may play a role in transcriptional regulation. binds to and activates cyclin-dependent kinase cdk8 that phosphorylates the ctd (carboxy-terminal domain) of the large subunit of rna polymerase ii (rnap ii).
30411	
30412	
30413	functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit kpnb1. acting autonomously, is thought to serve itself as receptor for nuclear localization signals (nls) and to promote translocation of import substrates through the nuclear pore complex (npc) by an energy requiring, ran-dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. mediates autonomously the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in association with kpnb1 mediates the nuclear import of h1 histone and the ran-binding site of ipo7 is not required but synergizes with that of kpnb1 in importin/substrate complex dissociation. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones. in vitro, mediates the nuclear import of hiv-1 reverse transcription complex (rtc) integrase.
30414	also acts as a tumor suppressor.
30415	
30416	
30417	
30418	
30419	
30420	protein transport. probably involved in vesicular traffic (by similarity).
30421	
30422	
30423	
30424	
30425	modulates transcriptional activation by steroid receptors such as nr3c1, nr3c2 and esr1. also modulates transcriptional repression by nuclear hormone receptors.
30426	
30427	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
30428	
30429	essental for release from glucose repression. it interacts and has functional relationship to the regulatory protein snf4. interacts also with sip1, sip2 and gal83. could phosphorylates cat8.
30430	
30431	
30432	
30433	type i collagen is a member of group i collagen (fibrillar forming collagen).
30434	
30435	
30436	
30437	
30438	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
30439	
30440	
30441	
30442	
30443	
30444	
30445	
30446	crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. the beta-2 subunit causes an increase in the plasma membrane surface area and in its folding into microvilli. interacts with tnr may play a crucial role in clustering and regulation of activity of sodium channels at nodes of ranvier (by similarity).
30447	probable transcription regulator.
30448	
30449	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
30450	
30451	
30452	this protein binds the camp response element (cre) (consensus: 5@#$%&-gtgacgt[ac][ag]-3@#$%&), a sequence present in many viral and cellular promoters. it binds to a tax-responsive enhancer element in the long terminal repeat of htlv-i.
30453	
30454	
30455	
30456	
30457	
30458	
30459	
30460	
30461	
30462	component of pa700, an atp-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20s proteasome) of the 26s complex. specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone t3-independent manner) and with retinoid x receptor (rxr). could be e3 ubiquitin- protein ligase which accepts ubiquitin from an e2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
30463	
30464	
30465	
30466	
30467	
30468	
30469	
30470	associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. it may function in the assembly and/or transport of ribosome.
30471	
30472	
30473	atp-dependent rna helicase involved nonsense-mediated mrna decay and ribosome biogenesis through rrna processing.
30474	
30475	
30476	
30477	
30478	
30479	
30480	
30481	
30482	
30483	may play a role in apoptosis by acting as a cell death substrate for caspases. is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. may be involved in the membrane ruffling process (by similarity).
30484	
30485	
30486	
30487	
30488	
30489	
30490	
30491	
30492	
30493	
30494	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
30495	transcriptional repressor.
30496	
30497	
30498	
30499	
30500	
30501	
30502	
30503	
30504	
30505	
30506	e3 ring-finger protein, member of the ubc2/rad6 epistasis group. associates to the e2 ubiquitin conjugating enzyme ubc2/rad6 to form the ubc2-rad18 ubiquitin ligase complex involved in postreplicative repair (prr) of damaged dna. the ubc2-rad18 complex cooperates with rad5 and the ubc13-mms2 dimer to attach mono-ubiquitin chains on lys-164 of pol30, which is necessary for prr. the ubc2-rad18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine.
30507	
30508	
30509	
30510	
30511	
30512	
30513	
30514	
30515	
30516	could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by ngf. may be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (by similarity).
30517	
30518	
30519	collagen type iv is specific for basement membranes.
30520	
30521	
30522	
30523	
30524	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
30525	
30526	
30527	
30528	
30529	
30530	
30531	acrosin is the major protease of mammalian spermatozoa. it is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
30532	
30533	
30534	
30535	
30536	converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single arg-val bond in plasminogen. by controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. play a direct role in facilitating neuronal migration.
30537	
30538	functions in segment determination through interaction with genes of bithorax (bx-c) and antennapedia (ant-c) complexes. it can behave as an activator of bx-c. involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. shown to bind zinc (in vitro).
30539	
30540	
30541	
30542	
30543	
30544	
30545	
30546	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
30547	
30548	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
30549	
30550	
30551	
30552	
30553	transcriptional regulator wich plays a central role in notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. acts as a transcriptional repressor when it is not associated with notch proteins. when associated with some notch protein, it acts as a transcriptional activator that activates transcription of notch target genes. probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. specifically binds to the immunoglobulin kappa-type j segment recombination signal sequence.
30554	
30555	
30556	
30557	
30558	binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
30559	
30560	
30561	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
30562	
30563	
30564	
30565	
30566	potassium channel activated by both membrane depolarization or increase in cytosolic ca(2+) that mediates export of k(+). it is also activated by the concentration of cytosolic mg(2+). its activation dampens the excitatory events that elevate the cytosolic ca(2+) concentration and/or depolarize the cell membrane. it therefore contributes to repolarization of the membrane potential. plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. in smooth muscles, its activation by high level of ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. in cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. kinetics of kcnma1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. highly sensitive to both iberiotoxin (ibtx) and charybdotoxin (ctx).
30567	
30568	
30569	
30570	
30571	
30572	
30573	
30574	spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. it associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
30575	irreversible conversion of delta-1-pyrroline-5- carboxylate (p5c), derived either from proline or ornithine, to glutamate. this is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. the preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
30576	
30577	
30578	
30579	
30580	
30581	
30582	
30583	catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
30584	thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
30585	binds rna.
30586	associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. it may function in the assembly and/or transport of ribosome.
30587	
30588	
30589	
30590	
30591	
30592	
30593	transcriptional repressor.
30594	
30595	mediates estrogen action in various target organs.
30596	this is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. catalyzes the rate-limiting conversions of tyrosine to dopa, dopa to dopa-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
30597	
30598	
30599	
30600	collagen type iv is specific for basement membranes.
30601	
30602	
30603	
30604	
30605	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
30606	
30607	
30608	
30609	
30610	
30611	
30612	
30613	
30614	
30615	
30616	
30617	
30618	
30619	
30620	
30621	
30622	
30623	
30624	
30625	
30626	
30627	
30628	
30629	
30630	promotes the exchange of ras-bound gdp by gtp. this protein positively controls the level of cellular camp at start, the stage at which the yeast cell division cycle is triggered.
30631	
30632	
30633	
30634	
30635	
30636	
30637	
30638	
30639	
30640	
30641	growth factor active on keratinocytes. possible major paracrine effector of normal epithelial cell proliferation.
30642	growth factor active on keratinocytes. possible major paracrine effector of normal epithelial cell proliferation.
30643	
30644	
30645	
30646	
30647	
30648	
30649	
30650	cleaves the large aggregating proteoglycans, aggrecan and versican.
30651	
30652	
30653	
30654	
30655	
30656	
30657	
30658	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna. associates with the complex p170-eif3.
30659	the elongation of primed dna templates by dna polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (pcna) and activator 1.
30660	
30661	
30662	
30663	
30664	
30665	may be involved in transcriptional regulation.
30666	
30667	
30668	
30669	
30670	
30671	
30672	represses transcription by binding to the bte site, a gc-rich dna element, in competition with the activator sp1. it also represses transcription by interacting with the corepressor sin3a and hdac1. activates rantes expression in t-cells.
30673	
30674	
30675	
30676	
30677	
30678	
30679	
30680	
30681	
30682	
30683	
30684	
30685	
30686	
30687	
30688	
30689	
30690	stimulates the atpase activity of several hsp70-type chaperones (by similarity).
30691	
30692	class-iii adh is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of s-(hydroxymethyl) glutathione.
30693	
30694	
30695	
30696	
30697	
30698	pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
30699	
30700	
30701	
30702	
30703	
30704	
30705	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
30706	
30707	
30708	
30709	
30710	
30711	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
30712	
30713	
30714	molecular chaperone. has atpase activity (by similarity).
30715	
30716	
30717	can stimulate e2f-dependent transcription. binds dna cooperatively with e2f family members through the e2 recognition site, 5@#$%&-tttc[cg]cgc-3@#$%&, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in dna replication. the dp2/e2f complex functions in the control of cell-cycle progression from g1 to s phase. the e2f-1/dp complex appears to mediate both cell proliferation and apoptosis.
30718	
30719	
30720	
30721	may play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
30722	
30723	transporter for the intake of folate. uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a v-type h(+)-pump.
30724	
30725	
30726	adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. binding of ap180 to clathrin triskelia induces their assembly into 60-70 nm coats.
30727	
30728	
30729	
30730	
30731	
30732	
30733	may be involved in transcriptional regulation.
30734	
30735	facilitative glucose transporter. probably a neuronal glucose transporter.
30736	
30737	probable constituent of the synaptonemal complex during meiosis. may interact with red1.
30738	
30739	
30740	
30741	
30742	
30743	
30744	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
30745	
30746	binds avidly to the au-rich element in fos and il3/interleukin-3 mrnas. in the case of the fos au-rich element, hur binds to a core element of 27 nucleotides that contain auuua, auuuua, and auuuuua motifs.
30747	
30748	not known, could be a tyrosine-phosphatase.
30749	
30750	
30751	
30752	
30753	
30754	
30755	
30756	
30757	
30758	
30759	
30760	
30761	
30762	
30763	
30764	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
30765	
30766	
30767	
30768	receptor for the hormone galanin. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity.
30769	
30770	
30771	acts as the target for the cell-cycle arrest and immunosuppressive effects of the fkbp12-rapamycin complex.
30772	
30773	
30774	
30775	
30776	
30777	
30778	
30779	
30780	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
30781	
30782	
30783	
30784	
30785	
30786	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
30787	
30788	
30789	
30790	
30791	
30792	
30793	
30794	
30795	
30796	
30797	
30798	
30799	
30800	
30801	
30802	
30803	
30804	
30805	binds to gt and gc boxes promoters elements. probable transcriptional activator.
30806	
30807	
30808	
30809	
30810	
30811	
30812	
30813	
30814	
30815	
30816	
30817	
30818	daughterless/achaete-scute complex heterodimers act as transcriptional activators of neural cell fates and are involved in sex determination.
30819	histones h1 are necessary for the condensation of nucleosome chains into higher order structures.
30820	
30821	
30822	
30823	
30824	
30825	
30826	
30827	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
30828	
30829	
30830	
30831	
30832	
30833	may play a role in the response to environmental stress. appears to act upstream of the jun n-terminal pathway.
30834	
30835	
30836	protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. necessary for apoptotic membrane blebbing. plays a role in smooth muscle contraction. required for centromere positioning and centromere- dependent exit from mitosis (by similarity).
30837	collagen type iv is specific for basement membranes.
30838	
30839	may be involved in transcriptional regulation.
30840	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
30841	required for protein transport from the er to the golgi complex.
30842	
30843	
30844	acts as the target for the cell-cycle arrest and immunosuppressive effects of the fkbp12-rapamycin complex.
30845	
30846	
30847	
30848	
30849	c9 is the final component of the complement system to be added in the assembly of the membrane attack complex. it is able to enter lipid bilayers, forming transmembrane channels.
30850	
30851	
30852	
30853	
30854	
30855	
30856	
30857	
30858	
30859	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
30860	
30861	
30862	
30863	
30864	
30865	
30866	
30867	
30868	high specificity for fatty acids. highest affinity for c18 chain length. decreasing the chain length or introducing double bonds reduces the affinity. may be involved in keratinocyte differentiation.
30869	
30870	
30871	the long isoform may play a role in neural and glial cell adhesion in the developing embryo. the short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. vital for embryonic development. essential for septate junctions. septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. required for the blood-brain barrier formation.
30872	phosphorylates and activates not only pkb/akt, but also pka, pkc-zeta, p70s6k and p90s6k/rsk. may play a general role in signaling processes and in development. could also play a role in sex differentiation processes.
30873	
30874	
30875	
30876	
30877	
30878	
30879	
30880	
30881	
30882	may be involved in transcriptional regulation.
30883	
30884	
30885	
30886	
30887	
30888	
30889	
30890	
30891	
30892	
30893	
30894	the production of the second messenger molecules diacylglycerol (dag) and inositol 1,4,5-trisphosphate (ip3) is mediated by activated phosphatidylinositol-specific phospholipase c enzymes. this enzyme is also required for cell growth.
30895	
30896	signaling adapter that couples activated growth factor receptors to signaling pathway. isoform p46shc and isoform p52shc, once phosphorylated, couple activated receptor tyrosine kinases to ras via the recruitment of the grb2/sos complex and are implicated in the cytoplasmic propagation of mitogenic signals. isoform p46shc and isoform p52shc may thus function as initiators of the ras signaling cascade in various nonneuronal systems. isoform p66shc does not mediate ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. isoform p66shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. the expression of isoform p66shc has been correlated with life span (by similarity).
30897	
30898	
30899	
30900	
30901	
30902	
30903	
30904	
30905	
30906	
30907	
30908	angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
30909	
30910	
30911	
30912	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
30913	
30914	
30915	
30916	
30917	
30918	
30919	
30920	
30921	possible adhesion molecule with a role in early hematopoiesis by mediating attachment to stromal cells. influences the survival and/or proliferation of b-cell precursors. binding to cells requires mn(2+) (by similarity).
30922	binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
30923	
30924	
30925	
30926	
30927	
30928	
30929	
30930	may be involved in transcriptional regulation.
30931	
30932	phosphorylates serine- and arginine-rich (sr) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable sr proteins to control rna splicing. phosphorylates serines, threonines and tyrosines (by similarity).
30933	
30934	
30935	phosphorylates serine- and arginine-rich (sr) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable sr proteins to control rna splicing. phosphorylates serines, threonines and tyrosines (by similarity).
30936	
30937	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
30938	might normally function as a repressor. ews-fusion- proteins (efps) may play a role in the tumorigenic process. they may disturb gene expression by mimicking, or interfering with the normal function of ctd-polii within the transcription initiation complex. they may also contribute to an aberrant activation of the fusion protein target genes.
30939	
30940	
30941	
30942	
30943	participates in processes of transmission and amplification of the visual signal. cgmp-pdes are the effector molecules in g-protein-mediated phototransduction in vertebrate rods and cones.
30944	
30945	
30946	
30947	this small ubiquitous enzyme is essential for maintenance and cell growth.
30948	
30949	
30950	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
30951	
30952	
30953	
30954	
30955	
30956	
30957	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
30958	
30959	
30960	
30961	catalyzes the addition of n-acetylglucosamine in beta 1- 6 linkage to the alpha-linked mannose of biantennary n-linked oligosaccharides. it is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.
30962	
30963	catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine.
30964	
30965	
30966	
30967	
30968	
30969	
30970	
30971	
30972	unwinds double-stranded dna and rna in a 3@#$%& to 5@#$%& direction. alterations of secondary structure may subsequently influence interactions with proteins or other nucleic acids. functions as a transcriptional activator (by similarity).
30973	
30974	guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction (by similarity).
30975	
30976	
30977	
30978	
30979	
30980	
30981	
30982	
30983	
30984	
30985	
30986	binds preferentially single-stranded dna and unwinds double stranded dna.
30987	
30988	
30989	key enzyme in the regulation of glycerol uptake and metabolism.
30990	
30991	
30992	
30993	
30994	
30995	
30996	
30997	
30998	
30999	the l3 protein is a component of the large subunit of cytoplasmic ribosomes.
31000	
31001	
31002	
31003	
31004	
31005	
31006	
31007	
31008	
31009	
31010	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
31011	
31012	
31013	essential for transcriptional activity of the hla class ii promoter; activation is via the proximal promoter. no dna binding of in vitro translated ciita was detected. may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal mhc class ii promoter, to elements of the transcription machinery, or both. alternatively it may activate hla class ii transcription by modifying proteins that bind to the mhc class ii promoter.
31014	
31015	
31016	
31017	
31018	
31019	associates with the organic matrix of bone and cartilage. thought to act as an inhibitor of bone formation.
31020	
31021	
31022	
31023	
31024	
31025	
31026	
31027	
31028	
31029	
31030	
31031	
31032	
31033	
31034	
31035	
31036	cd2 interacts with lymphocyte function-associated antigen (lfa-3) and cd48/bcm1 to mediate adhesion between t-cells and other cell types. cd2 is implicated in the triggering of t- cells, the cytoplasmic domain is implicated in the signaling function.
31037	
31038	
31039	
31040	
31041	
31042	
31043	
31044	
31045	
31046	
31047	
31048	
31049	
31050	
31051	
31052	
31053	
31054	
31055	
31056	
31057	
31058	
31059	
31060	
31061	
31062	transcription factor that binds to a symmetrical dna sequence (e-boxes) (5@#$%&-cacgtg-3@#$%&) that is found in a variety of viral and cellular promoters.
31063	
31064	
31065	
31066	
31067	
31068	
31069	
31070	
31071	
31072	
31073	
31074	
31075	
31076	
31077	
31078	
31079	
31080	required for protein transport from the er to the golgi complex.
31081	
31082	
31083	
31084	
31085	
31086	
31087	
31088	
31089	
31090	
31091	
31092	
31093	
31094	
31095	
31096	
31097	
31098	
31099	
31100	
31101	
31102	
31103	
31104	guanine nucleotide exchange factor that interacts with rhoa, but not with rac or cdc42. activates rhoa to promote cytoskeletal contraction and inhibit neurite outgrowth.
31105	
31106	
31107	
31108	
31109	phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
31110	
31111	
31112	
31113	
31114	
31115	
31116	
31117	
31118	
31119	
31120	bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. has also low glutathione peroxidase activity with t- butyl and cumene hydroperoxides. is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.
31121	
31122	
31123	
31124	
31125	
31126	
31127	
31128	
31129	
31130	
31131	
31132	
31133	
31134	
31135	
31136	
31137	
31138	ribosomal protein p0 is the functional equivalent of e.coli protein l10.
31139	
31140	controls phosphatidylcholine synthesis.
31141	
31142	
31143	
31144	
31145	
31146	
31147	
31148	
31149	
31150	
31151	
31152	
31153	
31154	major cellular poly(rc)-binding protein. binds also poly(ru).
31155	
31156	
31157	
31158	
31159	
31160	possible dna-binding subunit of the nuclear pore complex (npc). the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.
31161	
31162	may be an ion-channel regulator. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis. involved in adhesive protein-protein and protein-carbohydrate interactions.
31163	may be an ion-channel regulator. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis. involved in adhesive protein-protein and protein-carbohydrate interactions.
31164	
31165	
31166	receptor that binds specifically to pdgfb and has a tyrosine-protein kinase activity. phosphorylates tyr residues at the c-terminus of ptpn11 creating a binding site for the sh2 domain of grb2.
31167	
31168	
31169	
31170	
31171	
31172	
31173	
31174	
31175	
31176	specifically binds to domain c of the tax-responsive enhancer element in the long terminal repeat of htlv-i.
31177	
31178	
31179	
31180	
31181	
31182	
31183	
31184	
31185	
31186	
31187	
31188	acts as a transcriptional repressor.
31189	gtpase-activating protein for p21-rac and a phorbol ester receptor. may play an important role in neuronal signal- transduction mechanisms.
31190	
31191	
31192	
31193	part of a multiprotein post-splicing mrnp complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. binds spliced mrna upstream of exon-exon junctions.
31194	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
31195	
31196	
31197	binds to wnt proteins and inhibits their activities. may be involved in mesoderm segmentation.
31198	implicated in the control of cell fate decisions during development.
31199	
31200	
31201	
31202	
31203	
31204	
31205	
31206	
31207	
31208	
31209	
31210	
31211	
31212	
31213	
31214	
31215	
31216	
31217	
31218	motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport (by similarity).
31219	
31220	
31221	
31222	
31223	
31224	
31225	
31226	not known. the authors believe that it may be involved in transmembrane signal transduction through a postulated calcium- binding function, but the evidence for the existence of a calcium- binding region is weak.
31227	
31228	isoform b has an accelerated gef-independent gdp/gtp exchange and an impaired gtp hydrolysis, which is restored partially by gtpase-activating proteins. it is able to bind to the gtpase-binding domain of pak but not full-length pak in a gtp- dependent manner, suggesting that the insertion does not completely abolish effector interaction.
31229	this is a receptor for interleukin-3.
31230	
31231	may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. it binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (by similarity).
31232	
31233	
31234	
31235	
31236	
31237	
31238	
31239	
31240	
31241	
31242	
31243	
31244	non-essential protein involved in fatty acid metabolism.
31245	
31246	
31247	
31248	
31249	
31250	
31251	
31252	
31253	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
31254	
31255	transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. involved in particular in lens epithelial cell gene regulation and stress responses. may play an important role in lens epithelial to fiber cell terminal differentiation. may play a protective role during stress-induced apoptosis. isoform 2 is a more general and stronger transcriptional coactivator. isoform 2 may also act as an adapter to coordinate pre-mrna splicing. cellular cofactor for lentiviral integration.
31256	
31257	
31258	
31259	
31260	
31261	
31262	
31263	
31264	
31265	
31266	
31267	
31268	
31269	
31270	
31271	
31272	
31273	
31274	
31275	
31276	
31277	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates. associates with polr2g.
31278	
31279	may modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (by similarity).
31280	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
31281	
31282	
31283	
31284	
31285	
31286	
31287	
31288	
31289	may play a role in transporting nutrient from the gut lumen across the gutlining epithelial cell layer.
31290	
31291	
31292	
31293	
31294	
31295	
31296	
31297	
31298	
31299	
31300	
31301	
31302	
31303	binds the telomeric double-stranded ttaggg repeat and negatively regulates telomere length. involved in the regulation of the mitotic spindle.
31304	
31305	
31306	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
31307	
31308	
31309	
31310	
31311	possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. presents carbohydrate ligands to selectins.
31312	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
31313	
31314	
31315	
31316	part of a post-splicing multiprotein complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. component of the nuclear exosome 3@#$%&->5@#$%& exoribonuclease complex. required for the 3@#$%& processing of the 7s pre-rna to the mature 5.8s rrna. has a 3@#$%&-5@#$%& exonuclease activity (by similarity).
31317	
31318	
31319	
31320	
31321	
31322	corepressor targeting diverse transcription regulators (by similarity).
31323	
31324	
31325	
31326	
31327	
31328	
31329	
31330	
31331	udpgt is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. this isoform has specificity for phenols.
31332	
31333	
31334	
31335	
31336	
31337	
31338	
31339	
31340	
31341	can phosphorylate the alpha subunit of eif2 and may mediate translational control (by similarity).
31342	signal-transducing molecule. may have a common pathway with il6st. the soluble form inhibits the biological activity of lif by blocking its binding to receptors on target cells.
31343	
31344	
31345	
31346	
31347	
31348	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
31349	promotes the exchange of ras-bound gdp by gtp.
31350	
31351	
31352	
31353	
31354	
31355	
31356	
31357	phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin i. the alpha chain may bind calmodulin.
31358	
31359	
31360	
31361	
31362	
31363	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
31364	
31365	
31366	
31367	
31368	
31369	
31370	
31371	binds to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation. inhibits the phosphorylation of nucleosomal histones h3 and h2a by rps6ka5/msk1 and rps6ka3/rsk2 (by similarity).
31372	
31373	binds to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation. inhibits the phosphorylation of nucleosomal histones h3 and h2a by rps6ka5/msk1 and rps6ka3/rsk2 (by similarity).
31374	transcriptional regulator. isoform ii binds to the promoter region of s15 chorion gene, whereas isoform ii binds to cf2 promoter, thus having a probable autoregulatory role.
31375	
31376	
31377	
31378	binds rna.
31379	may play a role in cell-cycle regulation during the transition from gamete to embryo.
31380	
31381	component of a protein kinase signal transduction cascade. activates the jnk, but not erk or p38 kinase pathways.
31382	melanocyte differentiation antigen. may transport substances required for melanin biosynthesis (by similarity).
31383	promotes the exchange of ras-bound gdp by gtp.
31384	
31385	
31386	
31387	
31388	
31389	
31390	the function of brain maps is essentially unknown. phosphorylated map1b may play a role in the cytoskeletal changes that accompany neurite extension. possibly map1b binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules.
31391	
31392	
31393	
31394	
31395	
31396	
31397	
31398	
31399	
31400	
31401	
31402	
31403	
31404	
31405	
31406	
31407	
31408	function in general translation initiation by promoting the binding of the formylmethionine-trna to ribosomes. seems to function along with eif-2.
31409	
31410	involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. may play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. low-affinity receptor for agouti (by similarity). has a critical role in normal myelination in the central nervous system (by similarity).
31411	
31412	muscle contraction.
31413	
31414	
31415	
31416	
31417	
31418	
31419	
31420	calcium-dependent mitochondrial solute carrier (by similarity).
31421	collagen type iv is specific for basement membranes.
31422	
31423	
31424	
31425	f-actin capping proteins bind in a ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
31426	
31427	
31428	
31429	
31430	regulates apoptosis by enhancing phosphorylation and activation of akt1. increases release of tnfsf6 via the akt1/gsk3b/nfatc1 signaling cascade.
31431	
31432	
31433	implicated in the control of cell growth.
31434	
31435	
31436	
31437	
31438	
31439	
31440	
31441	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
31442	
31443	
31444	
31445	
31446	
31447	
31448	
31449	
31450	
31451	
31452	this protein binds 5s rna.
31453	
31454	potent vasoconstrictor (by similarity).
31455	
31456	
31457	
31458	
31459	
31460	may function as an antagonist of fibroblast growth factor (fgf) pathways and may negatively modulate respiratory organogenesis.
31461	
31462	
31463	plays an important role in the organization of the cytoskeleton. binds to and sequesters actin monomers (g actin) and therefore inhibits actin polymerization (by similarity).
31464	
31465	
31466	binds to, and destabilizes, ornithine decarboxylase. does not accelerate ornithine decarboxylase degeneration. oaz3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.
31467	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
31468	
31469	
31470	
31471	involved in nucleolar processing of pre-18s ribosomal rna. has a role in the nuclear export of 40s pre-ribosomal subunit to the cytoplasm (by similarity).
31472	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
31473	
31474	
31475	
31476	
31477	
31478	
31479	
31480	part of a multiprotein post-splicing mrnp complex involved in both mrna nuclear export and mrna surveillance. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. binds spliced mrna upstream of exon-exon junctions.
31481	putative polycomb group (pcg) protein. pcg proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. its association with a chromatin remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis.
31482	putative polycomb group (pcg) protein. pcg proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. its association with a chromatin remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis.
31483	
31484	
31485	
31486	
31487	
31488	
31489	
31490	
31491	
31492	
31493	
31494	
31495	
31496	
31497	
31498	transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. involved in particular in lens epithelial cell gene regulation and stress responses. may play an important role in lens epithelial to fiber cell terminal differentiation. may play a protective role during stress-induced apoptosis. isoform 2 is a more general and stronger transcriptional coactivator. isoform 2 may also act as an adapter to coordinate pre-mrna splicing. cellular cofactor for lentiviral integration.
31499	
31500	
31501	potential tumor suppressor for renal cell carcinoma.
31502	
31503	
31504	
31505	
31506	
31507	
31508	
31509	
31510	acts as a transcriptional repressor.
31511	
31512	
31513	
31514	
31515	
31516	
31517	
31518	
31519	
31520	may be required for patterning of muscle precursor cells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and cns formation. essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues.
31521	guanine nucleotide-binding proteins (g proteins) are involved as modulators or transducers in various transmembrane signaling systems.
31522	
31523	
31524	
31525	
31526	
31527	
31528	
31529	
31530	transcriptionally controlled transcription factor. binds to dna sites required for the transcription of alpha 1- antitrypsin, apolipoprotein ciii, transthyretin genes and hnf1- alpha. may be essential for development of the liver, kidney and intestine.
31531	
31532	
31533	required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors. may bind a rab gtpase such as vps21.
31534	
31535	
31536	
31537	
31538	binds the poly(a) tail of mrna.
31539	
31540	
31541	
31542	
31543	
31544	
31545	
31546	
31547	
31548	
31549	
31550	
31551	
31552	
31553	binds to pre-mrna. has high affinity for scaffold- attached region (sar) dna. bind to double- and single-stranded dna and rna.
31554	
31555	
31556	functions in segment determination through interaction with genes of bithorax (bx-c) and antennapedia (ant-c) complexes. it can behave as an activator of bx-c. involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. shown to bind zinc (in vitro).
31557	
31558	
31559	mbp1 binds to the c-myc promoter and acts as a transcriptional repressor. may be a tumor suppressor.
31560	
31561	
31562	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
31563	
31564	binds to the 40s ribosome and promotes the binding of methionyl-trnai and mrna.
31565	
31566	
31567	
31568	
31569	
31570	
31571	
31572	
31573	
31574	
31575	
31576	
31577	
31578	
31579	
31580	
31581	
31582	
31583	
31584	
31585	
31586	
31587	
31588	
31589	
31590	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
31591	
31592	
31593	
31594	
31595	
31596	
31597	
31598	
31599	
31600	
31601	
31602	stabilizes the cyclin h-cdk7 complex to form a functional cdk-activating kinase (cak) enzymatic complex. cak activates the cyclin-associated kinases cdc2/cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation. cak complexed to the core-tfiih basal transcription factor activates rna polymerase ii by serine phosphorylation of the repetitive c-terminus domain (ctd) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts. involved in cell cycle control and in rna transcription by rna polymerase ii.
31603	acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. one of the activated genes is an inhibitor of cyclin-dependent kinases. apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of bcl-2 expression.
31604	
31605	
31606	
31607	
31608	
31609	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
31610	
31611	
31612	
31613	
31614	
31615	
31616	
31617	
31618	
31619	
31620	
31621	
31622	
31623	
31624	forms a voltage-independent potassium channel activated by intracellular calcium. activation is followed by membrane hyperpolarization. thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. the channel is blocked by apamin (by similarity).
31625	
31626	
31627	
31628	
31629	
31630	
31631	
31632	
31633	
31634	
31635	transcription termination factor. binds to a 28 bp region within the trna(leu(uur)) gene at a position immediately adjacent to and downstream of the 16s rrna gene, this region comprises a tridecamer sequence critical for directing accurate termination. probably requires one or more components for termination activity.
31636	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (by similarity).
31637	
31638	
31639	
31640	
31641	
31642	gtpase-activating protein for rac1 and cdc42. promotes the exchange of rac or cdc42-bound gdp by gtp, thereby activating them. displays serine/threonine kinase activity.
31643	
31644	
31645	
31646	
31647	
31648	
31649	
31650	
31651	
31652	
31653	
31654	general coactivator that functions cooperatively with tafs and mediates functional interactions between upstream activators and the general transcriptional machinery. binds single-stranded dna.
31655	
31656	
31657	
31658	
31659	this protein participates in processes of transmission and amplification of the visual signal. necessary for the formation of a functional phosphodiesterase holoenzyme.
31660	potassium channel activated by both membrane depolarization or increase in cytosolic ca(2+) that mediates export of k(+). it is also activated by the concentration of cytosolic mg(2+). its activation dampens the excitatory events that elevate the cytosolic ca(2+) concentration and/or depolarize the cell membrane. it therefore contributes to repolarization of the membrane potential. plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. in smooth muscles, its activation by high level of ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. in cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. kinetics of kcnma1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. highly sensitive to both iberiotoxin (ibtx) and charybdotoxin (ctx).
31661	
31662	
31663	
31664	
31665	
31666	
31667	
31668	
31669	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
31670	
31671	
31672	
31673	
31674	
31675	
31676	signaling adapter that couples activated growth factor receptors to signaling pathway. isoform p46shc and isoform p52shc, once phosphorylated, couple activated receptor tyrosine kinases to ras via the recruitment of the grb2/sos complex and are implicated in the cytoplasmic propagation of mitogenic signals. isoform p46shc and isoform p52shc may thus function as initiators of the ras signaling cascade in various nonneuronal systems. isoform p66shc does not mediate ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. isoform p66shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. the expression of isoform p66shc has been correlated with life span (by similarity).
31677	pair-rule protein that regulates embryonic segmentation and adult bristle patterning. transcriptional repressor of genes that require a bhlh protein for their transcription (e.g. the fushi tarazu gene).
31678	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
31679	
31680	
31681	
31682	
31683	
31684	
31685	involved in the presentation of foreign antigens to the immune system.
31686	necessary for protein translocation in the endoplasmic reticulum.
31687	
31688	
31689	
31690	
31691	binds to actin and affects the structure of the cytoskeleton. at high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. by binding to pip2, it inhibits the formation of ip3 and dg.
31692	
31693	
31694	
31695	
31696	
31697	
31698	
31699	
31700	
31701	can repress hiv-1 transcription by binding to the hiv-1 long terminal repeat. involved in the regulation of cftr splicing. it promotes cftr exon 9 skipping by binding to the ug repeated motifs in the polymorphic region near the 3@#$%& splice site of this exon. the resulting aberrant splicing is associated with pathological features typical of cystic fibrosis.
31702	
31703	
31704	
31705	binds to the 23s rrna (by similarity).
31706	
31707	
31708	
31709	
31710	
31711	
31712	glandular kallikreins cleave met-lys and arg-ser bonds in kininogen to release lys-bradykinin.
31713	
31714	
31715	
31716	
31717	
31718	
31719	may play a role in transporting nutrient from the gut lumen across the gutlining epithelial cell layer.
31720	probably involved in mitochondrial protein import. is also required for efficient translocation of pre-pro-alpha-factor. involved in heme regulation of hap1, as a component of the high- molecular-weight (hmc) complex.
31721	
31722	
31723	
31724	
31725	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
31726	
31727	
31728	
31729	
31730	
31731	
31732	
31733	
31734	
31735	may play a role in apoptosis by acting as a cell death substrate for caspases. is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. may be involved in the membrane ruffling process (by similarity).
31736	
31737	polycomb group (pcg) protein. pcg proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. pcg proteins are not required to initiate repression, but to maintain it during later stages of development. they probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. component of the prc2 complex, which methylates lys-9 and lys-27 residues of histone h3.
31738	
31739	f-box-like protein involved in the recruitment of the ubiquitin/19s proteasome complex to nuclear receptor-regulated transcription units. plays an essential role in transcription activation mediated by nuclear receptors. probably acts as integral component of corepressor complexes that mediates the recruitment of the 19s proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (by similarity).
31740	
31741	
31742	
31743	
31744	
31745	
31746	
31747	
31748	
31749	
31750	
31751	
31752	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
31753	
31754	
31755	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
31756	seems to play an important role in regulating the production of neural crest cells by the neural tube (by similarity).
31757	
31758	
31759	
31760	
31761	
31762	
31763	
31764	serine/threonine-protein kinase that acts as a molecular sensor for dna damage. involved in dna nonhomologous end joining (nhej) required for double-strand break (dsb) repair and v(d)j recombination. must be bound to dna to express its catalytic properties. promotes processing of hairpin dna structures in v(d)j recombination by activation of the hairpin endonuclease artemis (dclre1c). the assembly of the dna-pk complex at dna ends is also required for the nhej ligation step. required to protect and align broken ends of dna. may also act as a scaffold protein to aid the localization of dna repair proteins to the site of damage. found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. also involved in modulation of transcription. recognizes the substrate consensus sequence [s/t- q]. phosphorylates ser-139 of histone variant h2ax/h2afx, thereby regulating dna damage response mechanism. phosphorylates dclre1c, c1d, c-abl/abl1, histone h1, hspca, c-jun/jun, p53/tp53, parp1, pou2f1, dhx9, srf, xrcc1, xrcc1, xrcc4, xrcc5, xrcc6, wrn, c- myc/myc and rfa2.
31765	
31766	
31767	implicated in mitochondrial protein import and macromolecular assembly. may facilitate the correct folding of imported proteins. may also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
31768	
31769	
31770	
31771	
31772	binds the sequence 5@#$%&-atcaatcaa-3@#$%&. acts as a transcriptional activator of pf4 in complex with meis1. converted into a potent transcriptional activator by the (1;19) translocation. may have a role in steroidogenesis and, subsequently, sexual development and differentiation.
31773	
31774	electrically silent transporter system. mediates sodium and chloride reabsorption. plays a vital role in the regulation of ionic balance and cell volume.
31775	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
31776	
31777	
31778	probable histone demethylase that specifically demethylates lys-9 of histone h3, thereby playing a central role in histone code. demethylation of lys residue generates formaldehyde and succinate. may be involved in hormone-dependent transcriptional activation, by participating to recruitment to androgen-receptor target genes (by similarity).
31779	
31780	
31781	
31782	required for vacuolar assembly and vacuolar traffic.
31783	
31784	
31785	
31786	
31787	
31788	
31789	
31790	receptor for tnfsf4/ox40l/gp34.
31791	converts lysophosphatidic acid (lpa) into phosphatidic acid by incorporating acyl moiety at the 2 position.
31792	
31793	ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached.
31794	
31795	
31796	
31797	
31798	
31799	this alpha-adrenergic receptor mediates its action by association with g proteins that activate a phosphatidylinositol- calcium second messenger system.
31800	
31801	
31802	
31803	
31804	
31805	
31806	
31807	
31808	pancreastatin strongly inhibits glucose induced insulin release from the pancreas.
31809	
31810	
31811	could function as a cell-adhesion protein. acts as a tumor suppressor. required for correct morphogenesis.
31812	
31813	
31814	
31815	
31816	
31817	
31818	this proteoglycan is a major component of extracellular matrix of cartilagenous tissues. a major function of this protein is to resist compression in cartilage. it binds avidly to hyaluronic acid via an n-terminal globular region.
31819	
31820	
31821	suppresses tnf- and cd40-induced nfkb1 activity at the level of the ikk complex, by inhibiting nfkbia degradation induced by tnf. when associated with pycard, activates casp1, leading to the secretion of mature proinflammatory cytokine il1b. may be a component of the inflammasome, a protein complex which also includes pycard, card8 and casp1 and whose function would be the activation of proinflammatory caspases.
31822	
31823	icam proteins are ligands for the leukocyte adhesion lfa-1 protein (integrin alpha-l/beta-2). icam2 may play a role in lymphocyte recirculation by blocking lfa-1-dependent cell adhesion. it mediates adhesive interactions important for antigen- specific immune response, nk-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
31824	
31825	sequence-specific rna-binding protein that regulates translation and mrna stability by binding the 3@#$%& untranslated regions (utrs) of mrna targets. may be required to support proliferation and self-renewal of stem cells (by similarity).
31826	
31827	
31828	involved in cytokinesis (potential).
31829	
31830	
31831	down-regulates the expression of several chemokine receptors. interferes with hiv-1 replication by suppressing tat- induced viral ltr promoter activity.
31832	
31833	
31834	
31835	
31836	
31837	
31838	
31839	
31840	
31841	
31842	
31843	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
31844	may play a role in regulating the early events of spermatogenesis by binding newly synthesized histones variants and transporting them to the nucleus.
31845	
31846	
31847	
31848	
31849	
31850	
31851	this protein is associated with sn-rnp u2. it helps the a@#$%& protein to bind stem loop iv of u2 snrna.
31852	
31853	
31854	
31855	
31856	transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
31857	
31858	
31859	
31860	induces the collapse and paralysis of neuronal growth cones. could potentially act as repulsive cues toward specific neuronal populations. binds to neuropilin (by similarity).
31861	
31862	
31863	
31864	
31865	
31866	
31867	
31868	
31869	
31870	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
31871	
31872	
31873	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
31874	
31875	receptor for group b coxsackieviruses and subgroup c of adenoviruses (ad2 and ad5), susceptibility to infection is correlated to its level of expression and availability at the plasma membrane of cells.
31876	nematode cuticles are composed largely of collagen-like proteins. the cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
31877	not known. may bind to chromatin.
31878	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
31879	apoptotic adaptor molecule specific for caspase-2 and fasl/tnf receptor-interacting protein rip. in the presence of rip and tradd, cradd recruites caspase-2 to the tnfr-1 signalling complex.
31880	
31881	
31882	not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
31883	
31884	
31885	
31886	
31887	
31888	
31889	
31890	
31891	
31892	
31893	type i collagen is a member of group i collagen (fibrillar forming collagen).
31894	
31895	
31896	
31897	
31898	
31899	
31900	
31901	
31902	
31903	
31904	may be able to bind plasminogen at cell surface and enhance plasminogen activation.
31905	
31906	
31907	
31908	
31909	ribosomal protein p0 is the functional equivalent of e.coli protein l10.
31910	
31911	
31912	receptor for glucocorticoids (gc). has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (gre) and as a modulator of other transcription factors. affects inflammatory responses, cellular proliferation and differentiation in target tissues. could act as a coactivator for stat5-dependent transcription upon growth hormone (gh) stimulation and could reveal an essential role of hepatic gr in the control of body growth.
31913	
31914	cleaves the large aggregating proteoglycans, aggrecan and versican.
31915	
31916	
31917	
31918	
31919	
31920	the intermediate chains seem to help dynein bind to dynactin 150 kda component.
31921	mediates potential-dependent transport of a variety of organic cations. may play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
31922	
31923	
31924	
31925	
31926	
31927	this is one of the chains of the nonenzymatic component (cf(0) subunit) of the mitochondrial atpase complex. f6 seems to be part of the stalk that links cf(0) to cf(1). also involved in the restoration of oligomycin-sensitive atpase activity to depleted f1-f0 complexes.
31928	
31929	
31930	
31931	
31932	binds to g-rich structures in 28s rrna and in mrnas. plays a regulatory role in the translation apparatus; inhibits cell-free translation of mrnas.
31933	induces the collapse and paralysis of neuronal growth cones. could potentially act as repulsive cues toward specific neuronal populations. binds to neuropilin (by similarity).
31934	
31935	
31936	
31937	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
31938	
31939	
31940	
31941	transcriptional regulator that probably plays an important role in lymphomagenesis.
31942	
31943	
31944	
31945	maintains high levels of reduced glutathione in the cytosol.
31946	subunit of the splicing factor sf3b required for @#$%&a@#$%& complex assembly formed by the stable binding of u2 snrnp to the branchpoint sequence (bps) in pre-mrna. sequence independent binding of sf3a/sf3b complex upstream of the branch site is essential, it may anchor u2 snrnp to the pre-mrna. may also be involved in the assembly of the @#$%&e@#$%& complex. belongs also to the minor u12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mrna intron.
31947	probable transcriptional activator.
31948	
31949	
31950	
31951	
31952	
31953	
31954	
31955	type i collagen is a member of group i collagen (fibrillar forming collagen).
31956	
31957	
31958	
31959	
31960	
31961	
31962	
31963	
31964	
31965	
31966	
31967	collagen vi acts as a cell-binding protein.
31968	
31969	
31970	
31971	
31972	
31973	
31974	
31975	
31976	
31977	
31978	
31979	muscle contraction.
31980	
31981	
31982	
31983	
31984	
31985	
31986	
31987	
31988	
31989	
31990	
31991	
31992	
31993	
31994	
31995	
31996	
31997	may mediate a process in spermatogenesis or may play a role in sex ratio distortion.
31998	may modulate the functions ascribed to brca1 in transcriptional regulation, dna repair, and/or cell cycle checkpoint control.
31999	
32000	
32001	
32002	
32003	
32004	
32005	
32006	
32007	produces nitric oxide (no) which is a messenger molecule with diverse functions throughout the body. in the brain and peripheral nervous system, no displays many properties of a neurotransmitter.
32008	
32009	
32010	
32011	membrane-cytoskeleton linker. the neural-specific isoforms may participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of ranvier and axonal initial segments.
32012	
32013	plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with rims1, rims2, cacna1d and cacna1b (by similarity).
32014	
32015	
32016	
32017	
32018	inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. receptor for dynorphins. may play a role in arousal and regulation of autonomic and neuroendocrine functions.
32019	hydrolyzes adenosine 5@#$%&-monophosphoramidate substrates such as amp-morpholidate, amp-n-alanine methyl ester, amp-alpha- acetyl lysine methyl ester and amp-nh2 (by similarity).
32020	
32021	type i collagen is a member of group i collagen (fibrillar forming collagen).
32022	
32023	
32024	
32025	
32026	
32027	
32028	
32029	
32030	
32031	
32032	
32033	
32034	
32035	
32036	
32037	
32038	
32039	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. binds poly(rg).
32040	required for the binding of mrna to ribosomes. functions in close association with eif4-f and eif4-a. binds near the 5@#$%&- terminal cap of mrna in presence of eif-4f and atp. promotes the atpase activity and the atp-dependent rna unwinding activity of both eif4-a and eif4-f.
32041	
32042	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
32043	
32044	
32045	
32046	required for the assembly of f-actin structures, such as stress fibers. depends on the rho-rock cascade for its activity. contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation.
32047	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
32048	
32049	
32050	
32051	repair polymerase. conducts @#$%!gap-filling@#$%! dna synthesis in a stepwise distributive fashion rather than in a processive fashion as for other dna polymerases. has a 5@#$%&-deoxyribose-5- phosphate lyase (drp lyase) activity.
32052	
32053	
32054	
32055	
32056	
32057	
32058	
32059	
32060	
32061	
32062	
32063	electrogenic sodium/bicarbonate cotransporter with a na(+):hco3(-) stoichiometry varying from 1:2 to 1:3. may regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular ph.
32064	transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney (by similarity).
32065	collagen type iv is specific for basement membranes. vital for embryonic development.
32066	
32067	
32068	
32069	
32070	cytotoxin and helminthotoxin. also induces noncytolytic histamine release from human basophils. involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. the proform acts as a proteinase inhibitor, reducing the activity of pappa.
32071	
32072	
32073	
32074	
32075	
32076	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
32077	plays a critical role in catalyzing the release of class ii hla-associated invariant chain-derived peptides (clip) from newly synthesized class ii hla molecules and freeing the peptide binding site for acquisition of antigenic peptides.
32078	
32079	
32080	
32081	
32082	
32083	
32084	
32085	
32086	
32087	
32088	removes 5-oxoproline from various penultimate amino acid residues except l-proline (by similarity).
32089	
32090	transcription factor that binds to sequence with multiple copies of ttc[cg]g present in its own promoter and that of the hnrpa2b1 gene. down-regulates transcription of these genes. binds to the retinoic acid response element (rare) agggttcaccgaaagttca. activates the proenkephalin gene independently of promoter binding, probably through protein- protein interaction. when secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the g0 or g1 phase.
32091	
32092	
32093	
32094	
32095	
32096	may be involved in transcriptional regulation.
32097	
32098	la protein plays a role in the transcription of rna polymerase iii. it is most probably a transcription termination factor. binds to the 3@#$%& termini of virtually all nascent polymerase iii transcripts. it is associated with precursor forms of rna polymerase iii transcripts including trna and 4.5s, 5s, 7s, and 7-2 rnas.
32099	
32100	
32101	
32102	
32103	
32104	
32105	important modulator in the hla class ii restricted antigen presentation pathway by interaction with the hla-dm molecule.
32106	
32107	
32108	
32109	
32110	
32111	
32112	
32113	
32114	
32115	
32116	
32117	sodium-independent, high-affinity transport of large neutral amino acids. involved in cellular amino acid uptake.
32118	
32119	
32120	electrogenic sodium/bicarbonate cotransporter with a na(+):hco3(-) stoichiometry varying from 1:2 to 1:3. may regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular ph.
32121	
32122	
32123	
32124	
32125	
32126	general transcription factor. btf3 can form a stable complex with rna polymerase ii. required for the initiation of transcription.
32127	
32128	
32129	may be involved in transcriptional regulation.
32130	
32131	does not act as an allosteric activator of the cholera toxin catalytic subunit (by similarity).
32132	
32133	
32134	
32135	
32136	
32137	
32138	
32139	
32140	
32141	
32142	
32143	may be involved in both signal transduction and cellular adhesion in the cns.
32144	
32145	may act as effector for golgi-bound hras and other ras- like proteins. may promote hras-mediated transformation.
32146	
32147	
32148	
32149	because s100a10 induces the dimerization of anxa2/p36, it may function as a regulator of protein phosphorylation in that the anxa2 monomer is the preferred target (in vitro) of tyrosine- specific kinase.
32150	it is required for normal cell growth and cell division.
32151	
32152	regulates the activity of the map kinase family in response to changes in the cellular environment (by similarity).
32153	
32154	
32155	involved in transcriptional regulation. represses the transcription of a number of genes including gastrin, stromelysin and enolase. binds to the g-rich box in the enhancer region of these genes.
32156	
32157	
32158	may play a role in apoptosis by acting as a cell death substrate for caspases. is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. may be involved in the membrane ruffling process (by similarity).
32159	
32160	
32161	
32162	
32163	
32164	
32165	
32166	
32167	
32168	may be involved in transcriptional regulation.
32169	
32170	
32171	inhibitor of protein-phosphatase 1.
32172	
32173	
32174	
32175	
32176	
32177	
32178	
32179	
32180	
32181	
32182	
32183	this protein is a minor sialoglycoprotein in human erythrocyte membranes. the blood group gerbich antigens and receptors for plasmodium falciparum merozoites are most likely located within the extracellular domain. glycophorin c plays an important role in regulating the stability of red cells.
32184	
32185	
32186	
32187	
32188	
32189	
32190	
32191	involved in pre-mrna splicing. is required together with atp and at least one other factor, for the first cleavage-ligation reaction. interacts directly with the pre-mrna.
32192	
32193	may play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (by similarity).
32194	
32195	inhibits the activity of il-1 by binding to its receptor. has no il-1 like activity.
32196	binds the poly(a) tail of mrna. may be involved in cytoplasmic regulatory processes of mrna metabolism. its function in translational initiation regulation can either be enhanced by paip1 or repressed by paip2. can probably bind to cytoplasmic rna sequences other than poly(a) in vivo. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain.
32197	
32198	the coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the er, via the golgi up to the trans golgi network. coatomer complex is required for budding from golgi membranes, and is essential for the retrograde golgi-to-er transport of dilysine-tagged proteins. in mammals, the coatomer can only be recruited by membranes associated to adp-ribosylation factors (arfs), which are small gtp-binding proteins; the complex also influences the golgi structural integrity, as well as the processing, activity, and endocytic recycling of ldl receptors (by similarity).
32199	
32200	
32201	
32202	candidate for involvement in male sterility.
32203	candidate for involvement in male sterility.
32204	histone demethylase that specifically demethylates lys-9 and lys-36 residues of histone h3, thereby playing a central role in histone code. does not demethylate histone h3 lys-4, h3 lys-27 nor h4 lys-20. demethylates trimethylated h3 lys-9 and h3 lys-36 residue, while it has no activity on mono- and dimethylated residues. demethylation of lys residue generates formaldehyde and succinate.
32205	granzyme b inhibitor.
32206	
32207	
32208	
32209	c7 is a constituent of the membrane attack complex. c7 binds to c5b forming the c5b-7 complex, where it serves as a membrane anchor.
32210	
32211	
32212	
32213	
32214	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. probably binds g- rich sequences in pre-mrnas.
32215	
32216	
32217	
32218	
32219	
32220	type i collagen is a member of group i collagen (fibrillar forming collagen).
32221	regulates synaptic membrane exocytosis (by similarity).
32222	
32223	
32224	aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
32225	
32226	
32227	
32228	
32229	
32230	
32231	collagen type iii occurs in most soft connective tissues along with type i collagen.
32232	
32233	
32234	3@#$%& exoribonuclease required for 5s rrna maturation and for the proper maturation of the 5@#$%& cistron of the trna-arg3 dicistronic gene. involved with rex2 in the maturation of the 5.8s rrna, and with rex2 and rex3, in the 3@#$%& processing of the u5l snrna.
32235	
32236	
32237	
32238	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
32239	
32240	
32241	acts as a transcriptional activator of the c-myc gene; binds dna nonspecifically (ref.3).
32242	
32243	
32244	may regulate the transcription of specific genes during normal development. may play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. implicated in the transduction of shh signal (by similarity).
32245	
32246	
32247	
32248	
32249	
32250	
32251	
32252	
32253	
32254	
32255	
32256	
32257	required for protein transport from the er to the golgi complex.
32258	
32259	
32260	
32261	
32262	
32263	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
32264	
32265	
32266	
32267	
32268	may be involved in transcriptional regulation.
32269	tyrosine-protein kinase receptor whose role is not yet clear.
32270	
32271	
32272	central component of the spliceosome, which may play a role in aligning the pre-mrna 5@#$%& and 3@#$%& exons for ligation. interacts with u5 snrna, and with pre-mrna 5@#$%& splice sites in b spliceosomes and 3@#$%& splice sites in c spliceosomes.
32273	involved in cytokinesis (potential).
32274	orphan nuclear receptor. binds dna as a monomer to hormone response elements (hre) containing a single core motif half-site preceded by a short a-t-rich sequence. this isomer binds to the consensus sequence 5@#$%&-[at][ta]a[at][cgt]taggtca-3@#$%&.
32275	
32276	
32277	
32278	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. this component is involved in redox-linked proton pumping.
32279	
32280	
32281	
32282	
32283	
32284	
32285	
32286	
32287	plays an important role in the degradation of dermatan and keratan sulfates.
32288	
32289	
32290	collagen type iv is specific for basement membranes. vital for embryonic development.
32291	
32292	
32293	mediates the voltage-dependent potassium ion permeability of excitable membranes. assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
32294	this is a membrane-bound, calcium-inhibitable adenylyl cyclase.
32295	
32296	
32297	
32298	
32299	
32300	
32301	
32302	
32303	
32304	collagen type iii occurs in most soft connective tissues along with type i collagen.
32305	
32306	
32307	
32308	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression (by similarity).
32309	
32310	
32311	
32312	
32313	
32314	
32315	binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
32316	
32317	
32318	
32319	
32320	
32321	
32322	
32323	forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. the channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mv. the open state has a weak anion selectivity whereas the closed state is cation- selective.
32324	
32325	
32326	
32327	
32328	
32329	downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small gtpases to the actin cytoskeleton.
32330	in addition to polymerase activity, this dna polymerase exhibits 3@#$%& to 5@#$%& and 5@#$%& to 3@#$%& exonuclease activity. it is able to utilize nicked circular duplex dna as a template and can unwind the parental dna strand from its template.
32331	bind to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation.
32332	
32333	
32334	
32335	
32336	
32337	
32338	
32339	
32340	mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons uaa and uag (by similarity).
32341	
32342	
32343	
32344	
32345	
32346	
32347	
32348	
32349	
32350	
32351	
32352	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
32353	
32354	
32355	
32356	
32357	clathrin is the major protein of the polyhedral coat of coated pits and vesicles. two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-golgi network.
32358	binds to iron-responsive elements (ires), which are stem-loop structures found in the 5@#$%&utr of ferritin, and delta aminolevulinic acid synthase mrnas, and in the 3@#$%&utr of transferrin receptor mrna. binding to the ire element in ferritin results in the repression of its mrna translation. binding of the protein to the transferrin receptor mrna inhibits the degradation of this otherwise rapidly degraded mrna.
32359	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
32360	
32361	
32362	
32363	
32364	
32365	
32366	
32367	
32368	
32369	
32370	
32371	
32372	
32373	
32374	
32375	
32376	
32377	tumor-associated antigen.
32378	thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. in vitro it binds mhc, f-actin and native thin filaments, and modifies the activity of actin-activated myosin atpase. it may modulate muscle contraction or may play a more structural role.
32379	
32380	
32381	
32382	
32383	sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate (by similarity).
32384	
32385	
32386	
32387	
32388	
32389	
32390	
32391	
32392	plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity.
32393	
32394	
32395	could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. may contribute to the metastatic phenotype.
32396	
32397	
32398	
32399	the insulin-like growth factors possess growth-promoting activity. in vitro, they are potent mitogens for cultured cells. igf-ii is influenced by placental lactogen and may play a role in fetal development.
32400	
32401	required only in the female germ line. it is important for oocyte formation and in the specification of the posterior structures of the embryo.
32402	may have a role in processing of pre-rrna or in the assembly of rrna into ribosomal subunits.
32403	
32404	converts inositol hexakisphosphate (insp6) to diphosphoinositol pentakisphosphate (insp7/pp-insp5). converts 1,3,4,5,6-pentakisphosphate (insp5) to pp-insp4.
32405	
32406	the proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with arg, phe, tyr, leu, and glu adjacent to the leaving group at neutral or slightly basic ph. the proteasome has an atp-dependent proteolytic activity.
32407	
32408	
32409	
32410	
32411	
32412	may be involved in transcriptional regulation.
32413	binds and presumably selects ubiquitin-conjugates for destruction. displays selectivity for longer polyubiquitin chains. modulates intestinal fluid secretion.
32414	
32415	
32416	
32417	
32418	
32419	
32420	component of a protein kinase signal transduction cascade. activates the erk and jnk kinase pathways by phosphorylation of map2k1 and map2k4. activates chuk and ikbkb, the central protein kinases of the nf-kappa-b pathway.
32421	
32422	type i collagen is a member of group i collagen (fibrillar forming collagen).
32423	implicated in the suppression of cell death. interacts with the bcl-2 and adenovirus e1b 19 kda proteins (by similarity).
32424	
32425	anti-proliferative protein.
32426	
32427	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
32428	binds to the u5 repressive element (u5re) of the human t cell leukemia virus type i long terminal repeat. it recognizes the 5@#$%&-tccacccc-3@#$%& sequence as a core motif and exerts a strong repressive effect on htlv-i ltr-mediated expression.
32429	involved in neurogenesis (by similarity).
32430	
32431	
32432	
32433	
32434	
32435	force generating protein of respiratory cilia. produces force towards the minus ends of microtubules. dynein has atpase activity; the force-producing power stroke is thought to occur on release of adp.
32436	
32437	
32438	
32439	
32440	
32441	
32442	
32443	
32444	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
32445	
32446	
32447	collagen type iii occurs in most soft connective tissues along with type i collagen.
32448	this protein promotes the gtp-dependent binding of aminoacyl-trna to the a-site of ribosomes during protein biosynthesis.
32449	
32450	
32451	
32452	binds specifically to nuclear core particles and acts as a transcriptional activator (by similarity).
32453	
32454	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
32455	responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase a). it catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (by similarity).
32456	
32457	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
32458	
32459	
32460	
32461	
32462	
32463	
32464	
32465	
32466	receptor for members of the ephrin-a family. binds to ephrin-a1, -a2, -a3, -a4 and -a5.
32467	
32468	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
32469	
32470	
32471	
32472	
32473	
32474	
32475	
32476	
32477	
32478	
32479	
32480	
32481	signal-transducing molecule. the receptor systems for il6, lif, osm, cntf, il11, ctf1 and bsf3 can utilize gp130 for initiating signal transmission. binds to il6/il6r (alpha chain) complex, resulting in the formation of high-affinity il6 binding sites, and transduces the signal. does not bind il6. may have a role in embryonic development (by similarity).
32482	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
32483	
32484	
32485	binds galactosides. may play a role in thymocyte- epithelial interactions relevant to the biology of the thymus. the isoform short acts as an eosinophil chemoattractant. is a ligand for havcr2/tim3. induces t-helper type 1 lymphocyte (th1) death.
32486	
32487	
32488	
32489	
32490	
32491	
32492	may be involved in transcriptional regulation.
32493	interacts with the e6 protein of the cancer-associated human papillomavirus types 16 and 18. the e6/e6-ap complex binds to and targets the p53 tumor-suppressor protein for ubiquitin- mediated proteolysis. it is an e3 ubiquitin-protein ligase which accepts ubiquitin from an e2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. it can target itself for ubiquitination in vitro and efficiently promotes its own degradation in vivo. it appears that only unmodified e6-ap molecules can bind efficiently to p53 in the presence of the hpv e6 oncoprotein.
32494	may be involved in ca(2+)-dependent exocytosis of secretory vesicles through ca(2+) and phospholipid binding to the c2 domain or may serve as ca(2+) sensors in the process of vesicular trafficking and exocytosis (by similarity).
32495	
32496	
32497	splicing factor that in its dephosphorylated form acts as a general repressor of pre-mrna splicing. seems to interfere with the u1 snrnp 5@#$%&-splice recognition of snrp70. required for splicing repression in m-phase cells and after heat shock. may be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
32498	
32499	
32500	molecular chaperone; assists the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
32501	
32502	
32503	interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. can also catalyze the reaction of ec 5.4.2.4 (synthase) and ec 3.1.3.13 (phosphatase), but with a reduced activity.
32504	
32505	type i collagen is a member of group i collagen (fibrillar forming collagen).
32506	binds specifically to the dna sequence 5@#$%&-aacaat-3@#$%&. activates transcription of col2a1 and agc1 in vitro.
32507	
32508	
32509	
32510	ncf2, ncf1, and a membrane bound cytochrome b558 are required for activation of the latent nadph oxidase (necessary for superoxide production).
32511	may play an important role in fibrillogenesis by controlling lateral growth of collagen ii fibrils.
32512	
32513	
32514	
32515	may act as a specific coactivator for the mammalian tefs. may play a role in the development of skeletal muscles.
32516	
32517	
32518	preferably binds to a peptide derived from the signal sequence of most hla-a, -b, -c and -g molecules.
32519	
32520	
32521	
32522	
32523	
32524	required for protein transport from the er to the golgi complex.
32525	involved in ph regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. major proton extruding system driven by the inward sodium ion chemical gradient. plays an important role in signal transduction (by similarity).
32526	major high molecular weight protein of desmosomes. involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
32527	
32528	
32529	
32530	may play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (by similarity).
32531	
32532	
32533	
32534	
32535	
32536	
32537	
32538	
32539	binds specifically to u7 snrna.
32540	
32541	
32542	
32543	mediates rac1-dependent reorganization of actin filaments (by similarity). participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
32544	
32545	
32546	probable transcription factor. may play an important role in recruitment of elf4 into pml nuclear bodies.
32547	
32548	
32549	
32550	
32551	
32552	
32553	
32554	
32555	
32556	cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (nk) cells to mediate tumor cell lysis.
32557	
32558	
32559	
32560	
32561	
32562	
32563	
32564	probable transcription factor that binds to the dna sequence 5@#$%&-gc[ta][ac]atta[ga]-3@#$%&. activates the transcription of the ghrh gene. plays an important role in pituitary development.
32565	
32566	
32567	putative odorant receptor.
32568	involved in oxygen transport from the lung to the various peripheral tissues.
32569	
32570	
32571	
32572	
32573	
32574	binds opioids in the presence of acidic lipids; probably involved in cell contact.
32575	
32576	
32577	
32578	
32579	
32580	
32581	
32582	plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. involved in paracellular magnesium reabsorption. required for a selective paracellular conductance. may form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.
32583	
32584	hydrolyzes adenosine 5@#$%&-monophosphoramidate substrates such as amp-morpholidate, amp-n-alanine methyl ester, amp-alpha- acetyl lysine methyl ester and amp-nh2 (by similarity).
32585	
32586	factor ix is a vitamin k-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor x to its active form in the presence of ca(2+) ions, phospholipids, and factor viiia.
32587	
32588	
32589	
32590	
32591	facilitative glucose transporter. probably a neuronal glucose transporter.
32592	
32593	
32594	
32595	
32596	
32597	
32598	
32599	cam-kinase ii (camk2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.
32600	
32601	
32602	may be involved in transcriptional regulation.
32603	
32604	
32605	
32606	potential tumor suppressor. acts as a phosphoinositide 3-phosphatase by regulating ptdins(3,4,5)p3 levels. involved in regulation of the akt1 signaling pathway. the unphosphorylated form cooperates with aip1 to suppress akt1 activation.
32607	
32608	
32609	
32610	
32611	
32612	transcriptional repressor.
32613	
32614	
32615	this protein is a component of the heterogenous nuclear ribonucleoprotein (hnrnp) complexes which provide the substrate for the processing events that pre-mrnas undergo before becoming functional, translatable mrnas in the cytoplasm. binds poly(rg).
32616	
32617	receptor for sema4d. plays a role in rhoa activation and subsequent changes of the actin cytoskeleton. plays a role in axon guidance, invasive growth and cell migration.
32618	
32619	
32620	
32621	
32622	
32623	
32624	
32625	thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. in vitro it binds mhc, f-actin and native thin filaments, and modifies the activity of actin-activated myosin atpase. it may modulate muscle contraction or may play a more structural role.
32626	
32627	
32628	
32629	
32630	
32631	required for fusion of er-derived vesicles with the golgi during er-to-golgi protein transport, probably by mediating correct membrane localization of ypt1.
32632	receptor for lutropin-choriogonadotropic hormone. the activity of this receptor is mediated by g proteins which activate adenylate cyclase.
32633	
32634	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
32635	
32636	
32637	
32638	
32639	
32640	
32641	catalyzes the transfer of mannose from dol-p-man to lipid-linked oligosaccharides.
32642	
32643	catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the c-terminus of several proteins having the c-terminal sequence cys-aliphatic-aliphatic-x. the alpha subunit is thought to participate in a stable complex with the substrate. the beta subunit binds the peptide substrate.
32644	
32645	
32646	tautomerization of d-dopachrome with decarboxylation to give 5,6-dihydroxyindole (dhi).
32647	
32648	
32649	
32650	
32651	associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. it may function in the assembly and/or transport of ribosome.
32652	this protein promotes the gtp-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome.
32653	
32654	
32655	in addition to gelatin and collagens, it cleaves kiss1 at a gly-|-leu bond.
32656	factor h functions as a cofactor in the inactivation of c3b by factor i and also increases the rate of dissociation of the c3bbb complex (c3 convertase) and the (c3b)nbb complex (c5 convertase) in the alternative complement pathway.
32657	
32658	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
32659	
32660	
32661	
32662	
32663	
32664	
32665	
32666	
32667	
32668	
32669	
32670	orphan receptor.
32671	high-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. may also function as an ecotropic retroviral leukemia receptor.
32672	
32673	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. may play a role in cftr trafficking to the plasma membrane. causes the formation of thin, actin-rich surface projections called filopodia.
32674	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. may play a role in cftr trafficking to the plasma membrane. causes the formation of thin, actin-rich surface projections called filopodia.
32675	
32676	
32677	
32678	
32679	
32680	
32681	
32682	
32683	
32684	
32685	
32686	transcriptional repressor of genes that require a bhlh protein for their transcription. may act as a negative regulator of myogenesis by inhibiting the functions of myod1 and ash1 (by similarity).
32687	
32688	molecular chaperone; assists the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
32689	
32690	
32691	serine/threonine protein kinase involved in regulating m phase functions during the cell cycle. may also be part of the signaling network controlling cellular adhesion. in vitro, is able to phosphorylate cdc25c and casein (by similarity).
32692	
32693	potent inhibitor of the complement membrane attack complex (mac) action. acts by binding to the c8 and/or c9 complements of the assembling mac, thereby preventing incorporation of the multiple copies of c9 required for complete formation of the osmolytic pore. this inhibitor appears to be species-specific. involved in signal transduction for t-cell activation complexed to a protein tyrosine kinase.
32694	
32695	
32696	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
32697	
32698	
32699	one hip oligomer binds the atpase domains of at least two hsc70 molecules dependent on activation of the hsc70 atpase by hsp40. stabilizes the adp state of hsc70 that has a high affinity for substrate protein. through its own chaperone activity, it may contribute to the interaction of hsc70 with various target proteins (by similarity).
32700	
32701	
32702	
32703	
32704	
32705	may play a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. there are four molecules of fkbp12 per skeletal muscle ryr. ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
32706	
32707	
32708	
32709	
32710	
32711	enhances ar-mediated transactivation. transactivation decreases as the poly-gln length within ar increases.
32712	the muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of g proteins. primary transducing effect is adenylate cyclase inhibition.
32713	
32714	
32715	insulin-regulated facilitative glucose transporter. binds cytochalasin b in a glucose-inhibitable manner. seems to be a dual-specific sugar transporter as it is inhibitable by fructose.
32716	could be involved in oogenesis. involved in the regulation of endosome dynamics. implicated in a novel signal transduction pathway, in which isoform 3 and csk are sequentially activated by rhod to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
32717	
32718	
32719	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
32720	
32721	binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
32722	
32723	
32724	
32725	
32726	
32727	
32728	
32729	
32730	collagen type iv is specific for basement membranes.
32731	
32732	
32733	
32734	
32735	
32736	
32737	
32738	
32739	
32740	
32741	plays a fundamental role in microtubule-organizing center structure and function.
32742	
32743	
32744	
32745	
32746	
32747	
32748	
32749	serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor creb.
32750	
32751	krueppel is a gap class segmentation protein. it is involved in the segmentation of the embryo and in the differentiation of the malpighian tubules.
32752	
32753	binds to pre-mrna. has high affinity for scaffold- attached region (sar) dna. bind to double- and single-stranded dna and rna.
32754	
32755	
32756	
32757	
32758	
32759	
32760	
32761	
32762	
32763	collagen type iv is specific for basement membranes.
32764	
32765	ena/vasp proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodelling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. vasp promotes actin nucleation and increases the rate of actin polymerization in the presence of capping protein. plays a role in actin-based activity of listeria monocytogenes in platelets (by similarity).
32766	
32767	involved in the biosynthesis of molybdopterin precursor z from guanosine.
32768	this enzyme is required for electron transfer from nadp to cytochrome p450 in microsomes. it can also provide electron transfer to heme oxygenase and cytochrome b5. may function to clear the olfactory organ (antennae) from accumulating chemicals.
32769	
32770	
32771	
32772	
32773	responsible for the reduction of the keto group on the c-3 of sterols.
32774	
32775	
32776	
32777	may play a role in anchoring the cytoskeleton to the plasma membrane (by similarity to dystrophin).
32778	
32779	type i collagen is a member of group i collagen (fibrillar forming collagen).
32780	
32781	
32782	
32783	
32784	may play an important role in fibrillogenesis by controlling lateral growth of collagen ii fibrils.
32785	
32786	
32787	
32788	tumor-associated antigen.
32789	
32790	
32791	
32792	
32793	binds to gtp-bound form of rho and to profilin. acts in a rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. it is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics.
32794	
32795	
32796	
32797	specifically promotes functional cell surface expression of olfactory receptors, but not of other gpcrs (by similarity).
32798	
32799	
32800	
32801	necessary for scanning and involved in initiation site selection. promotes the assembly of 48s ribosomal complexes at the authentic initiation codon of a conventional capped mrna.
32802	involved in signal transduction through the wnt pathway.
32803	
32804	
32805	
32806	
32807	
32808	
32809	
32810	
32811	
32812	
32813	
32814	
32815	
32816	
32817	
32818	
32819	
32820	
32821	
32822	probable transcriptional regulator involved in developmental processes.
32823	
32824	
32825	
32826	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
32827	
32828	
32829	
32830	
32831	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
32832	
32833	
32834	this is a component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. this protein may mediate formation of the complex between cytochromes c and c1.
32835	
32836	may act as a gtpase activating protein for rab family protein(s).
32837	
32838	
32839	
32840	this is one of the five types (d1 to d5) of receptors for dopamine. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
32841	
32842	
32843	
32844	
32845	
32846	gtpase-activating protein for rhoa, and perhaps for cdc42. may be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. acts a tumor suppressor in hepatocellular carcinoma cells.
32847	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
32848	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
32849	
32850	may be involved in transcriptional regulation.
32851	molecular chaperone; assists the folding of proteins upon atp hydrolysis. known to play a role, in vitro, in the folding of actin and tubulin.
32852	can efficiently cleave only isg15 fusions including native isg15 conjugates linked via isopeptide bonds. necessary to maintain a critical cellular balance of isg15-conjugated proteins in both healthy and stressed organisms.
32853	
32854	
32855	
32856	
32857	
32858	could act as a modulator of transcription.
32859	
32860	
32861	
32862	
32863	
32864	
32865	
32866	
32867	may be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.
32868	may act to physically and functionally link transcription and pre-mrna processing (by similarity).
32869	
32870	
32871	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
32872	
32873	
32874	
32875	
32876	
32877	
32878	isoform 4 may play a role in spermatogenesis.
32879	
32880	
32881	
32882	
32883	
32884	
32885	
32886	
32887	
32888	
32889	
32890	
32891	
32892	
32893	
32894	
32895	
32896	
32897	
32898	
32899	
32900	
32901	
32902	
32903	
32904	
32905	
32906	
32907	
32908	
32909	
32910	
32911	
32912	
32913	
32914	
32915	
32916	
32917	
32918	conversion of folates to polyglutamate derivatives. this allows tissues to concentrate folate at higher levels than in plasma.
32919	
32920	
32921	
32922	probably involved in the repair of mismatches in dna.
32923	
32924	
32925	tyrosine-protein kinase receptor whose role is not yet clear.
32926	
32927	
32928	
32929	
32930	
32931	
32932	
32933	
32934	
32935	
32936	
32937	component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.
32938	its physiological substrate seems to be the small heat shock protein (hsp27/hsp25). in vitro can phosphorylate glycogen synthase at ser-7 and tyrosine hydroxylase (on ser-19 and ser-40). this kinase phosphorylates ser in the peptide sequence, hyd-x-r- x(2)-s, where hyd is a large hydrophobic residue (by similarity). mediates both erk and p38 mapk/mapk14 dependent neutrophil responses. participates in tnf alpha-stimulated exocytosis of secretory vesicles in neutrophils. plays a role in phagocytosis- induced respiratory burst activity.
32939	
32940	
32941	
32942	
32943	
32944	
32945	
32946	sequence-specific dna-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. ap-2 factors bind to the consensus sequence 5@#$%&-gccnnnggc-3@#$%& and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. they also suppress a number of genes including mcam/muc18, c/ebp alpha and myc. ap-2 alpha is the only ap-2 protein required for early morphogenesis of the lens vesicle (by similarity).
32947	
32948	
32949	
32950	may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. alternatively, it may play a structural role in indirect flight muscle. vital for embryonic development.
32951	
32952	produces nitric oxide (no) which is a messenger molecule with diverse functions throughout the body. in macrophages, no mediates tumoricidal and bactericidal actions.
32953	
32954	
32955	
32956	acts as a transcriptional activator of the c-myc gene; binds dna nonspecifically (ref.3).
32957	
32958	
32959	
32960	
32961	
32962	may be required for testis development.
32963	
32964	
32965	
32966	
32967	
32968	
32969	
32970	
32971	
32972	receptor for gdnf. mediates the gdnf-induced autophosphorylation and activation of the ret receptor (by similarity).
32973	
32974	
32975	
32976	
32977	
32978	hydrolyzes udp-glucose to glucose 1-phosphate and ump and adp-ribose to ribose 5-phosphate and amp. the physiological substrate is probably udp-glucose. poor activity on other substrates such as adp-glucose, cdp-glucose, gdp-glucose and gdp- mannose.
32979	
32980	
32981	
32982	
32983	
32984	
32985	receptor for activated thrombin coupled to g proteins that stimulate phosphoinositide hydrolysis.
32986	
32987	
32988	putative transcription factor involved in pancreas development and function.
32989	
32990	
32991	
32992	
32993	
32994	
32995	
32996	
32997	
32998	
32999	
33000	
33001	muscle contraction.
33002	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
33003	
33004	
33005	activates the jun n-terminal pathway through activation of the map kinase kinase map2k7. acts synergistically with prdx3 to regulate the activation of nf-kappa-b in the cytosol. this activation is kinase-dependent and involves activating the ikk complex, the ikbkb-containing complex that phosphorylates inhibitors of nf-kappa-b.
33006	
33007	
33008	
33009	
33010	
33011	
33012	
33013	
33014	
33015	cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
33016	
33017	
33018	may be involved in transcriptional regulation.
33019	
33020	
33021	
33022	pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. channel properties are modulated by camp and subunit assembly. mediates the rapidly activating component of the delayed rectifying potassium current in heart (ikr). isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
33023	
33024	acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
33025	
33026	
33027	
33028	sequence-specific transcriptional activator. recognizes the dna sequence 5@#$%&-c[ca]ggaagt-3@#$%&.
33029	component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to atp synthesis.
33030	
33031	
33032	
33033	
33034	
33035	
33036	
33037	catalyzes the posttranslational formation of 4- hydroxyproline in -xaa-pro-gly- sequences in collagens and other proteins.
33038	
33039	
33040	
33041	
33042	
33043	
33044	
33045	may be involved in the synthesis of gangliosides gd1c, gt1a, gq1b and gt3 from gd1a, gt1b, gm1b and gd3 respectively.
33046	
33047	
33048	
33049	
33050	
33051	
33052	
33053	
33054	
33055	
33056	
33057	
33058	
33059	involved in the transduction of mitogenic signals from the cell membrane to the nucleus.
33060	
33061	
33062	
33063	
33064	
33065	
33066	
33067	
33068	dual specificity kinase that activates the jun kinases mapk8 (jnk1) and mapk9 (jnk2) as well as mapk14 (p38) but not mapk1 (erk2) or mapk3 (erk1).
33069	
33070	
33071	
33072	
33073	key enzyme for ketone body catabolism. transfers the coa moiety from succinate to acetoacetate. formation of the enzyme-coa intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
33074	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
33075	
33076	
33077	
33078	
33079	
33080	
33081	
33082	
33083	
33084	may be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
33085	contributes to the lung@#$%&s defense against inhaled microorganisms. binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. it could participate in the extracellular reorganization or turnover of pulmonary surfactant.
33086	
33087	
33088	required for neural tube formation. essential for normal heart development and function. acts as a transcriptional repressor of anf by binding to both gata4 and nkx2-5 and repressing their transcriptional activator activities. participates in the negative regulation of cell proliferation signaling (by similarity).
33089	may be involved in transcriptional regulation.
33090	
33091	
33092	
33093	potential tumor suppressor for renal cell carcinoma.
33094	
33095	
33096	
33097	this protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
33098	
33099	binds to gtp-bound form of rho and to profilin. acts in a rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. it is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics (by similarity).
33100	
33101	
33102	
33103	
33104	
33105	
33106	
33107	
33108	
33109	
33110	
33111	
33112	
33113	may be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. may also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
33114	
33115	
33116	
33117	
33118	
33119	
33120	type v collagen is a member of group i collagen (fibrillar forming collagen). it is a minor connective tissue component of nearly ubiquitous distribution. type v collagen binds to dna, heparan sulfate, thrombospondin, heparin, and insulin.
33121	
33122	might be a stress protein involved in the control of bacterial proliferation.
33123	
33124	
33125	
33126	
33127	
33128	
33129	
33130	ef-1-beta and ef-1-delta stimulate the exchange of gdp bound to ef-1-alpha to gtp.
33131	
33132	
33133	
33134	
33135	involved in the transduction of mitogenic signals from the cell membrane to the nucleus. may play a role in the postsynaptic responses of hippocampal neuron.
33136	as an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
33137	
33138	may function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment (by similarity).
33139	
33140	
33141	
33142	inhibitor of protein-phosphatase 1. this protein may be important in hormonal control of glycogen metabolism. hormones that elevate intracellular camp increase i-1 activity in many tissues. i-1 activation may impose camp control over proteins that are not directly phosphorylated by pka. following a rise in intracellular calcium, i-1 is inactivated by calcineurin (or pp2b). does not inhibit type-2 phosphatases.
33143	
33144	
33145	
33146	
33147	
33148	
33149	
33150	
33151	implicated in development of nervous system and pancreatic endocrine cells.
33152	
33153	
33154	
33155	
33156	
33157	likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the rxxx[kr]r consensus motif.
33158	
33159	
33160	il-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of b-cells into ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
33161	
33162	
33163	
33164	
33165	
33166	
33167	
33168	plays important roles in both rhabdomere development and in photoreceptor cell survival. might function as a calcium- sequestering @#$%!sponge@#$%! to regulate the amount of free cytoplasmic calcium. it binds 0.3 mole of ca(2+) per mole of protein.
33169	
33170	
33171	
33172	
33173	
33174	
33175	
33176	
33177	
33178	seems to act exclusively upon threonine residues (by similarity).
33179	
33180	
33181	
33182	
33183	
33184	
33185	
33186	
33187	transcriptional repressor.
33188	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
33189	
33190	
33191	
33192	
33193	
33194	
33195	
33196	
33197	
33198	
33199	
33200	
33201	
33202	does not act as an allosteric activator of the cholera toxin catalytic subunit (by similarity).
33203	
33204	
33205	
33206	
33207	
33208	
33209	
33210	attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to na-k atpase, to the lymphocyte membrane protein gp85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. in skeletal muscle, isoform mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
33211	
33212	transcriptional regulator that acts as repressor or activator. binds, in-vitro, to nf-e2 binding sites. play important roles in coordinating transcription activation and repression by mafk.
33213	
33214	
33215	
33216	
33217	
33218	
33219	
33220	
33221	aminopeptidase n is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
33222	dna polymerase specifically involved in dna repair. plays an important role in translesion synthesis, where the normal high fidelity dna polymerases cannot proceed and dna synthesis stalls. plays an important role in the repair of uv-induced pyrimidine dimers. depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. may play a role in hypermutation at immunoglobulin genes. forms a schiff base with 5@#$%&-deoxyribose phosphate at abasic sites, but does not have lyase activity. targets poli to replication foci.
33223	
33224	
33225	
33226	
33227	
33228	
33229	
33230	
33231	
33232	
33233	
33234	
33235	
33236	
33237	
33238	
33239	coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
33240	
33241	may act as receptor for class i mhc antigens.
33242	inhibitor of protein-phosphatase 1.
33243	
33244	
33245	
33246	
33247	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. may play a role in cftr trafficking to the plasma membrane. causes the formation of thin, actin-rich surface projections called filopodia.
33248	
33249	complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. known to act on mmp-1, mmp-2, mmp-3, mmp-7 and mmp-9.
33250	
33251	
33252	
33253	
33254	has e3 ubiquitin protein ligase activity. regulates the levels of casp8 and casp10 by targeting them for proteasomal degradation. protects cells against apoptosis induced by tnf. binds phosphatidylinositol-5-phosphate and phosphatidylinositol-3- phosphate.
33255	
33256	required for the retention of luminal endoplasmic reticulum proteins. determines the specificity of the luminal er protein retention system. also required for normal vesicular traffic through the golgi. this receptor recognizes k-d-e-l.
33257	
33258	
33259	
33260	
33261	
33262	plays a central role in dna repair by facilitating cellular response to dna repair. required for appropriate cell cycle arrests after ionizing irradiation in both the s-phase and the g2 phase of the cell cycle. involved in transcriptional regulation of p21 in response to dna damage. required for fancd2 targeting to sites of dna damage. may function as a transcriptional regulator. mediates e2-dependent ubiquitination (by similarity).
33263	
33264	
33265	transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (by similarity).
33266	transcription factor that binds specifically to the distal ras-responsive element (rre) in the calcitonin gene promoter and augment the ras/raf-mediated transcriptional response of that promoter. may be involved in ras/raf-mediated cell differentiation.
33267	
33268	unknown.
33269	
33270	
33271	
33272	
33273	
33274	
33275	
33276	
33277	
33278	
33279	
33280	
33281	
33282	
33283	
33284	
33285	
33286	
33287	
33288	
33289	
33290	
33291	
33292	part of the complex catalyzing the transfer of n- acetylglucosamine from udp-n-acetylglucosamine to phosphatidylinositol, the first step of gpi biosynthesis.
33293	
33294	
33295	
33296	
33297	component of unactivated mammalian steroid receptor complexes that sediment at 8-10 s. may have a rotamase activity. may play a role in the intracellular trafficking of hetero- oligomeric forms of steroid hormone receptors.
33298	component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. the n-terminus interacts with and regulates xpd whereas an intact c- terminus is required for a successful escape of rnap ii form the promoter.
33299	
33300	
33301	
33302	
33303	
33304	ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. this enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the c-terminal glycine of ubiquitin. also binds to free monoubiquitin and may prevent its degradation in lysosomes. the homodimer may have atp-independent ubiquitin ligase activity.
33305	component of a protein kinase signal transduction cascade. regulates the jnk and erk5 pathways by phosphorylating and activating map2k5 and map2k7. plays a role in caveolae kiss- and-run dynamics (by similarity).
33306	
33307	
33308	
33309	
33310	
33311	
33312	
33313	
33314	
33315	
33316	
33317	catalyzes the covalent attachment of ubiquitin to other proteins (by similarity).
33318	
33319	
33320	
33321	
33322	
33323	
33324	
33325	
33326	
33327	
33328	may function as a transcription factor with dual roles in transcription initiation and termination. binds to two sites, me1a1 and me1a2, within the c-myc promoter having greater affinity for the former. also binds to multiple g/c-rich sites within the promoter of the sp1 family of transcription factors.
33329	
33330	
33331	
33332	
33333	
33334	essential for the control of the cell cycle at the g2/m (mitosis) transition.
33335	could be an important component in vesicular trafficking cycling between the golgi complex and the apical plasma membrane. could be involved in myelin biogenesis and/or myelin function.
33336	may be involved in transcriptional regulation.
33337	
33338	
33339	
33340	
33341	
33342	
33343	
33344	
33345	
33346	
33347	
33348	
33349	
33350	
33351	
33352	
33353	
33354	type i collagen is a member of group i collagen (fibrillar forming collagen).
33355	
33356	
33357	
33358	
33359	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
33360	
33361	
33362	
33363	
33364	
33365	
33366	
33367	rna-binding protein. required for internal initiation of translation of human rhinovirus rna. may be involved in translationally coupled mrna turnover. implicated with other rna- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the fos mrna mediated by the major coding- region determinant of instability (mcrd) domain.
33368	
33369	
33370	
33371	
33372	
33373	
33374	
33375	
33376	
33377	
33378	
33379	immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. participates also in the recruitment of tyrosine kinase syk.
33380	type i collagen is a member of group i collagen (fibrillar forming collagen).
33381	
33382	
33383	
33384	
33385	
33386	
33387	
33388	
33389	
33390	
33391	
33392	
33393	may be involved in transcriptional regulation.
33394	
33395	
33396	may be involved in the final steps of mitochondrial differentiation within the flagellum.
33397	
33398	
33399	
33400	transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
33401	
33402	
33403	may be involved in adhesive interactions of activated t and nk cells during the late phase of the immune response. may function at a time after t and nk cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
33404	
33405	
33406	
33407	may play a role in transcriptional regulation. in vitro, is associated with a kinase activity toward both rna polymerase ii c-terminal domain and cdk2 (cak).
33408	
33409	
33410	
33411	
33412	
33413	
33414	
33415	substrate-recognition component of the scf (skp1-cul1-f- box protein)-type e3 ubiquitin ligase complex (by similarity).
33416	
33417	
33418	
33419	
33420	
33421	
33422	
33423	
33424	
33425	
33426	
33427	
33428	signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. functions as a receptor for membrane- bound ligands delta and serrate to regulate cell-fate determination. upon ligand activation, and releasing from the cell membrane, the notch intracellular domain (nicd) forms a transcriptional activator complex with su(h) (suppressor of hairless) and activates genes of the e(spl) complex. essential for proper differentiation of ectoderm. fringe (fng) acts in the golgi to determine the type of o-linked fucose on the egf modules in n, altering the ability of n to bind with delta (dl). o-fut1 also has a role in modulating the interaction.
33429	
33430	
33431	
33432	
33433	
33434	
33435	
33436	
33437	
33438	
33439	
33440	
33441	
33442	involved in skeletal muscle regeneration, specifically at the onset of cell fusion. also involved in macrophage-derived giant cells (mgc) and osteoclast formation from mononuclear precursors (by similarity).
33443	implicated in mitochondrial protein import and macromolecular assembly. may facilitate the correct folding of imported proteins. may also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
33444	
33445	
33446	
33447	
33448	
33449	
33450	
33451	
33452	
33453	
33454	
33455	
33456	
33457	
33458	
33459	
33460	
33461	
33462	
33463	
33464	
33465	
33466	
33467	
33468	
33469	collagen type iii occurs in most soft connective tissues along with type i collagen.
33470	
33471	
33472	
33473	
33474	
33475	
33476	
33477	
33478	
33479	
33480	
33481	
33482	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
33483	
33484	
33485	involved in double-stranded break repair. plays a central role in genetic recombination and dna repair by promoting the annealing of complementary single-stranded dna and by stimulation of the rad51 recombinase.
33486	
33487	
33488	
33489	
33490	
33491	
33492	
33493	
33494	
33495	microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. most probably involved in vesicular trafficking processes, in particular endocytosis.
33496	
33497	high affinity receptor for semaphorins 3c, 3f, vegf-165 and vegf-145 isoforms of vegf, and the plgf-2 isoform of pgf.
33498	
33499	
33500	inhibitor of protein-phosphatase 1.
33501	
33502	probable receptor. may mediate intraellular signaling.
33503	destroys radicals which are normally produced within the cells and which are toxic to biological systems.
33504	
33505	
33506	
33507	
33508	
33509	binds to the inner side of the nucleosomal dna thus altering the interaction between the dna and the histone octamer. may be involved in the process which maintains transcribable genes in a unique chromatin conformation. inhibits the phosphorylation of nucleosomal histones h3 and h2a by rps6ka5/msk1 and rps6ka3/rsk2 (by similarity).
33510	
33511	
33512	regulates actin polymerization by stimulating the actin- nucleating activity of the arp2/3 complex. binds to hsf1/hstf1 and forms a complex on heat shock promoter elements (hse) that negatively regulates hsp90 expression.
33513	
33514	
33515	
33516	transcriptional activator that binds to dna sequences containing the consensus pentanucleotide 5@#$%&-cgga[at]-3@#$%&.
33517	tubulin is the major constituent of microtubules. it binds two moles of gtp, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain.
33518	
33519	
33520	
33521	
33522	this is a receptor for glucagon-like peptide 2. the activity of this receptor is mediated by g proteins which activate adenylyl cyclase.
33523	
33524	
33525	
33526	collagen type iii occurs in most soft connective tissues along with type i collagen.
33527	
33528	
33529	involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole.
33530	
33531	
33532	stimulates exchange activity on rho proteins in vitro, but not on cdc42, ras or rac. may bind calcium ions.
33533	
33534	
33535	
33536	muscle contraction.
33537	
33538	
33539	
33540	methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (may methylate hnrnpa1 and histones). methylates supt5h.
33541	catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of nad. it is the rate limiting component in the mammalian nad biosynthesis pathway (by similarity).
33542	implicated in development of nervous system and pancreatic endocrine cells.
33543	probably involved in nervous system development and function.
33544	
33545	may bind dna (by similarity).
33546	
33547	
33548	blocks the elongation and depolymerization of the actin filaments at the pointed end. the tmod/tm complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (by similarity).
33549	
33550	involved in cytokinesis (potential).
33551	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
33552	phosphorylates serine- and arginine-rich (sr) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable sr proteins to control rna splicing. phosphorylates serines, threonines and tyrosines (by similarity).
33553	
33554	
33555	
33556	atp-dependent rna helicase involved nonsense-mediated mrna decay and ribosome biogenesis through rrna processing.
33557	type i collagen is a member of group i collagen (fibrillar forming collagen).
33558	
33559	
33560	
33561	may have a role in processing of pre-rrna or in the assembly of rrna into ribosomal subunits.
33562	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
33563	
33564	
33565	
33566	
33567	
33568	
33569	
33570	
33571	orphan nuclear receptor.
33572	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber.
33573	
33574	
33575	
33576	forms transcriptional repressor complexes by associating with mad, sin3, yy1 and n-cor. interacts in the late s-phase of dna-replication with dnmt1 in the other transcriptional repressor complex composed of dnmt1, dmap1, pcna, caf1.
33577	
33578	
33579	probable zinc protease. may mediate cell-cell or cell- matrix interactions. isoform 2 displays alpha-secretase activity for app.
33580	does not act as an allosteric activator of the cholera toxin catalytic subunit (by similarity).
33581	
33582	
33583	
33584	
33585	
33586	plays an adhesive role by integrating collagen bundles. it is probably associated with the surface of interstitial collagen fibrils via col1. the col2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large n-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (by similarity).
33587	favors the reduction of estrogens and androgens. also has 20-alpha-hsd activity. uses preferentially nadh.
33588	
33589	
33590	
33591	
33592	
33593	the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
33594	
33595	
33596	involved in amino acid efflux from the vacuole to the cytoplasm. capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine.
33597	
33598	
33599	
33600	
33601	pkc is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. pkc also serves as the receptor for phorbol esters, a class of tumor promoters.
33602	
33603	
33604	
33605	
33606	
33607	
33608	
33609	
33610	transports 1 ca(2+) and 1 k(+) in exchange for 4 na(+) (by similarity).
33611	
33612	stores iron in a soluble, nontoxic, readily available form. important for iron homeostasis. has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
33613	
33614	
33615	
33616	
33617	receptor for glutamate. the activity of this receptor is mediated by a g-protein that inhibits adenylate cyclase activity.
33618	
33619	
33620	
33621	
33622	
33623	
33624	
33625	required for protein transport from the er to the golgi complex.
33626	may be involved in modulating chromatin formation and contribute to regulation of cell proliferation.
33627	
33628	
33629	has antiviral, antibacterial and anticancer activities.
33630	
33631	
33632	
33633	
33634	
33635	
33636	
33637	
33638	
33639	
33640	
33641	
33642	methylates cpg residues. preferentially methylates hemimethylated dna. it is responsible for maintaining methylation patterns established in development. mediates transcriptional repression by direct binding to hdac2.
33643	functions in segment determination through interaction with genes of bithorax (bx-c) and antennapedia (ant-c) complexes. it can behave as an activator of bx-c. involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. shown to bind zinc (in vitro).
33644	may be involved in transcriptional regulation.
33645	
33646	
33647	
33648	
33649	
33650	
33651	
33652	
33653	sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. controls the reabsorption of sodium in kidney, colon, lung and sweat glands. also plays a role in taste perception.
33654	
33655	
33656	
33657	
33658	
33659	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
33660	
33661	
33662	
33663	
33664	
33665	
33666	
33667	
33668	
33669	
33670	
33671	
33672	
33673	
33674	
33675	
33676	component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
33677	acts in a rho-dependent manner to recruit pfy1 to the membrane. required for the assembly of f-actin structures, such as actin cables and stress fibers. nucleates actin filaments. binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. required for cytokinesis, and transcriptional activation of the serum response factor. dfr proteins couple rho and src tyrosine kinase during signaling and the regulation of actin dynamics. functions as a scaffold protein for mapre1 and apc to stabilize microtubules and promote cell migration.
33678	
33679	
33680	
33681	
33682	
33683	
33684	
33685	plasma membrane-associated small gtpase which cycles between an active gtp-bound and an inactive gdp-bound state. in active state binds to a variety of effector proteins to regulate cellular responses. involved in epithelial cell polarization processes. may play a role in cftr trafficking to the plasma membrane. causes the formation of thin, actin-rich surface projections called filopodia.
33686	
33687	
33688	
33689	
33690	
33691	
33692	
33693	
33694	
33695	responsible for the deacetylation of lysine residues on the n-terminal part of the core histones (h2a, h2b, h3 and h4). histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. histone deacetylases act via the formation of large multiprotein complexes. involved in muscle maturation by repressing transcription of myocyte enhancer mef2c. during muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (by similarity).
33696	
33697	
33698	may play a role in the control of gene expression.
33699	
33700	
33701	
33702	this protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.
33703	
33704	
33705	
33706	
33707	
33708	may have a function in cell adhesion and/or receptor signaling.
33709	
33710	it may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
33711	may be involved in transcriptional regulation.
33712	
33713	
33714	
33715	
33716	
33717	
33718	
33719	may play a role in a signaling pathway regulating nuclear functions of cell proliferaration. phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
33720	
33721	
33722	
33723	
33724	
33725	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
33726	
33727	
33728	
33729	
33730	
33731	involved in the presentation of foreign antigens to the immune system.
33732	
33733	
33734	plays an important role in the organization of the cytoskeleton. binds to and sequesters actin monomers (g actin) and therefore inhibits actin polymerization (by similarity).
33735	plays an important role in the organization of the cytoskeleton. binds to and sequesters actin monomers (g actin) and therefore inhibits actin polymerization (by similarity).
33736	
33737	could be involved in the control of plant growth and development. phosphorylates two ribosomal proteins, p14 and p16.
33738	
33739	
33740	plays an important role in the elongation step of protein synthesis.
33741	
33742	
33743	
33744	
33745	may facilitate pttg1 nuclear translocation.
33746	involved in the mineralization and structural organization of enamel. involved in the extension of enamel during the secretory stage of dental enamel formation.
33747	
33748	
33749	
33750	
33751	
33752	
33753	
33754	
33755	
33756	
33757	
33758	
33759	
33760	
33761	
33762	
33763	probable transcriptional regulator involved in developmental processes.
33764	
33765	
33766	
33767	
33768	
33769	
33770	
33771	potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. the effects of betacellulin are probably mediated by the egf receptor and other related receptors.
33772	
33773	
33774	
33775	
33776	
33777	branching enzyme that converts linear into branched poly-n-acetyllactosaminoglycans. introduces the blood group i antigen during embryonic development. it is closely associated with the development and maturation of erythroid cells.
33778	
33779	
33780	
33781	probable collagen protein.
33782	
33783	
33784	
33785	il-8 is a chemotactic factor that attracts neutrophils, basophils, and t-cells, but not monocytes. it is also involved in neutrophil activation. it is released from several cell types in response to an inflammatory stimulus. il-8(6-77) has a 5-10-fold higher activity on neutrophil activation, il-8(5-77) has increased activity on neutrophil activation and il-8(7-77) has a higher affinity to receptors cxcr1 and cxcr2 as compared to il-8(1-77), respectively.
33786	
33787	
33788	involved in the packaging of pre-mrna into hnrnp particles, transport of poly(a) mrna from the nucleus to the cytoplasm and may modulate splice site selection.
33789	the interaction with sm proteins inhibits their assembly on u rna and interferes with snrnp biogenesis. inhibits the binding of survival motor neuron protein (smn) to sm proteins. may participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.
33790	acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.
33791	
33792	
33793	
33794	
33795	
33796	
33797	
33798	
33799	
33800	ena/vasp proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodelling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. enah induces the formation of f-actin rich outgrowths in fibroblasts. acts syngeristically with baiap2alpha and downstream of ntn1 to promote filipodia formation. required for the actin-based mobility of listeria monocytogenes (by similarity).
33801	
33802	
33803	functions as an e3-type small ubiquitin-like modifier (sumo) ligase, stabilizing the interaction between ube2i and the substrate, and as a sumo-tethering factor. plays a crucial role as a transcriptional coregulation in various cellular pathways, including the stat pathway, the p53 pathway and the steroid hormone signaling pathway. the effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
33804	isoform 7 behaves as a receptor and binds the secreted isoform 5. the binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. can bind to grb2 adapter protein.
33805	
33806	
33807	catalyzes the formation of s-adenosylmethionine from methionine and atp.
33808	
33809	
33810	
33811	
33812	
33813	
33814	may play a role in epithelioid conversion of fibroblasts.
33815	
33816	
33817	
33818	
33819	
33820	
33821	
33822	
33823	
33824	
33825	
33826	
33827	
33828	
33829	
33830	
33831	may serve as part of a signaling pathway coupling the fc receptor to the activation of the respiratory burst. may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
33832	
33833	
33834	
33835	
33836	
33837	
33838	involved in the trafficking of secretory vesicles from the endoplasmic reticulum (er) to the golgi. regulates correct targeting and tethering of vesicles to target membranes by catalyzing the selective recruitment of proteins required for tethering and fusion onto membranes. vesicular transport depends on shuttling of ypt1 between membrane and cytosol by gdi1, probably by recycling it to its membrane of origin after a vesicle fusion event. required for sorting and transport of proteins from the er through the golgi compartment. also involved in the recycling of membrane proteins.
33839	
33840	
33841	
33842	
33843	
33844	
33845	
33846	
33847	
33848	
33849	
33850	
33851	
33852	
33853	major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle.
33854	neurofilaments usually contain three intermediate filament proteins: l, m, and h which are involved in the maintenance of neuronal caliber. nf-h has an important function in mature axons that is not subserved by the two smaller nf proteins.
33855	
33856	
33857	hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin a.
33858	
33859	
33860	
33861	
33862	
33863	
33864	may be involved in tissue-specific alternative rna processing events.
33865	
33866	
33867	
33868	
33869	
33870	
33871	
33872	
33873	
33874	binds to actin filaments in muscle and nonmuscle cells. plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. smooth muscle contraction is regulated by interaction with caldesmon. in nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments.
33875	
33876	trap proteins are part of a complex whose function is to bind calcium to the er membrane and thereby regulate the retention of er resident proteins. may be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
33877	
33878	adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. seems to be involved in activation of nf- kappa-b and jnk and in apoptosis. is regulated by tank/itraf which competes with tnfrsf5/cd40 for binding. seems to play a role t- cell dependent immune responses.
33879	
33880	gaba, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the gaba/benzodiazepine receptor and opening an integral chloride channel.
33881	
33882	a49 is easily dissociated from the rest of pol a (pol i), producing the form a*, which shows impaired transcriptional activity and increased sensitivity to alpha-amanitin. the function of a49 might be linked to the rnase h activity that was found associated with this subunit.
33883	
33884	
33885	
33886	
33887	
33888	
33889	essential for cell viability. taf9 and taf9b are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. may have a role in gene regulation associated with apoptosis. tafs are components of the transcription factor iid (tfiid) complex, the tbp-free tafii complex (tftc), the pcaf histone acetylase complex and the staga transcription coactivator-hat complex. tfiid or tftc are essential for the regulation of rna polymerase ii-mediated transcription.
33890	may play a role in apoptosis. may act as a tumor suppressor.
33891	cartilage matrix protein is a major component of the extracellular matrix of nonarticular cartilage. it binds to collagen.
33892	
33893	
33894	
33895	
33896	
33897	signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. srp68 binds the 7s rna, srp72 binds to this complex subsequently. this ribonucleoprotein complex might interact directly with the docking protein in the er membrane and possibly participate in the elongation arrest function.
33898	
33899	
33900	
33901	
33902	
33903	involved in dna double strand break (dsb) repair.
33904	
33905	
33906	
33907	
33908	
33909	
33910	
33911	
33912	
33913	
33914	catalyzes the covalent attachment of ubiquitin to other proteins. mediates the selective degradation of short-lived and abnormal proteins. functions in the e6/e6-ap-induced ubiquitination of p53/tp53.
33915	
33916	
33917	
33918	
33919	unknown. required for normal hearing. may have a role in the development and maintenance of the stereocilia bundles. might function as an anchoring/scaffolding protein in hair cells. could be involved in the functional network formed by ush1c, cdh23 and myo7a that is required for cohesion of the growing hair bundle.
33920	
33921	
33922	
33923	
33924	
33925	may be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (by similarity).
33926	binds to the promoter regions of proteolipid proteins of the central nervous system. may play a role in the development of neurons and oligodendrogalia in the cns. may regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.
33927	
33928	
33929	
33930	
33931	
33932	
33933	
33934	
33935	
33936	
33937	
33938	
33939	
33940	
33941	
33942	contactins mediate cell surface interactions during nervous system development. has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. probably involved in neuronal activity in the auditory system (by similarity).
33943	
33944	
33945	
33946	
33947	
33948	
33949	
33950	
33951	
33952	
33953	may play a role in a signaling pathway regulating nuclear functions of cell proliferaration. phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
33954	
33955	
33956	
33957	
33958	
33959	
33960	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
33961	mediates the association of the molecular chaperones hsc70 and hsp90 (hspca and hspcb).
33962	
33963	
33964	
33965	
33966	
33967	may be involved in transcriptional regulation as a repressor. candidate gene for wolf-hirschhorn (4p-) syndrome (whs).
33968	
33969	
33970	
33971	
33972	putative atp-dependent rna helicase.
33973	
33974	binds to membranes enriched in phosphatidylinositol-4,5- biphosphate (ptdins(4,5)p2). modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (by similarity). regulates receptor-mediated endocytosis.
33975	
33976	
33977	
33978	
33979	
33980	
33981	regulatory subunit of the dimeric ube1c-appbp1 e1 enzyme. e1 activates nedd8 by first adenylating its c-terminal glycine residue with atp, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-ube1c thioester and free amp. e1 finally transfers nedd8 to the catalytic cysteine of ube2m. necessary for cell cycle progression through the s-m checkpoint. overexpression of appbp1 causes apoptosis through deregulation of nedd8 conjugation.
33982	catalyzes the covalent attachment of ubiquitin to other proteins. in association with the e3 enzyme bre1 and lge1, it plays a role in transcription regulation by catalyzing the monoubiquitination of lys-123 of histone h2b leading to the trimethylation of histone h3 lys-4 by compass, the localization of the paf1 complex to the chromatin and the silencing of telomeric- associated genes. in association with the e3 enzyme rad18, it catalyzes the monoubiquitination of pol30 lys-164, involved in postreplication repair of uv-damaged dna. the ubc2-rad18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine. in association with the e3 enzyme ubr1, is involved in n-end rule-dependent protein degradation. also involved in sporulation.
33983	this protein promotes the gtp-dependent binding of aminoacyl-trna to the a-site of ribosomes during protein biosynthesis.
33984	
33985	
33986	
33987	
33988	
33989	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
33990	
33991	
33992	
33993	
33994	
33995	
33996	
33997	
33998	
33999	together with krt19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
34000	
34001	terminates the action of gaba by its high affinity sodium-dependent reuptake into presynaptic terminals (by similarity).
34002	
34003	
34004	phosphorylates ins(1,3,4,5,6)p5 at position 2 to form ins(1,2,3,4,5,6)p6 (insp6 or phytate). insp6 is involved in many processes such as mrna export, nonhomologous end-joining, endocytosis, ion channel regulation. it also protects cells from tnf-alpha-induced apoptosis.
34005	
34006	supplies the nucleotide substrate for thymidylate synthetase.
34007	has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (drf1). induces microspike formation, in vivo (by similarity). in vitro, stimulates n-wasp- induced arp2/3 complex activation in the absence of cdc42 (by similarity). may play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. implicated in regulation of actin polymerization and cell adhesion.
34008	
34009	
34010	
34011	
34012	
34013	
34014	
34015	
34016	
34017	
34018	
34019	
34020	
34021	
34022	part of a post-splicing multiprotein complex. involved in nonsense-mediated decay (nmd) of mrnas containing premature stop codons. essential for embryonic viability.
34023	
34024	core component of the centrosome throughout spermatogenesis. may participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. is a target of several homeotic genes.
34025	
34026	
34027	calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity.
34028	
34029	
34030	
34031	
34032	
34033	
34034	
34035	
34036	muscle contraction.
34037	
34038	
34039	
34040	
34041	
34042	
34043	
34044	lacks cytidine deaminase activity, at least on rna molecules (monomeric nucleoside substrates or synthetic apob rna template). unable to reduce hiv-1 infectivity in vitro.
34045	
34046	
34047	
34048	
34049	
34050	
34051	involved in the replication of mitochondrial dna.
34052	
34053	
34054	
34055	
34056	
34057	
34058	
34059	
34060	interacts with the cytoplasmic tail of nmda receptor subunits and shaker-type potassium channels. required for synaptic plasticity associated with nmda receptor signaling. overexpression or depletion of dlg4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. may reduce the amplitude of accn3 acid-evoked currents by retaining the channel intracellularly. may regulate the intracellular trafficking of adr1b.
34061	
34062	
34063	
34064	
34065	
34066	
34067	
34068	
34069	involved in calcium binding and microtubule stabilization.
34070	ppiases accelerate the folding of proteins. it catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
34071	
34072	
34073	may be involved in transcriptional regulation.
34074	may be involved in the regulation of gene transcription and chromatin structure.
34075	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. this is a component of the iron-sulfur (ip) fragment of the enzyme.
34076	
34077	
34078	
34079	
34080	
34081	
34082	
34083	
34084	may act at junctions between the membrane and the cytoskeleton.
34085	
34086	
34087	
34088	
34089	
34090	
34091	
34092	cell surface proteoglycan that bears heparan sulfate. putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (by similarity).
34093	
34094	
34095	
34096	
34097	
34098	
34099	
34100	
34101	adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. binding generally results in the modulation of the activity of the binding partner.
34102	
34103	
34104	
34105	
34106	
34107	
34108	
34109	
34110	
34111	
34112	
34113	
34114	
34115	
34116	
34117	
34118	
34119	binds preferentially single-stranded dna and unwinds double stranded dna.
34120	
34121	
34122	this protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate (by similarity).
34123	transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.
34124	may be involved in transcriptional regulation.
34125	
34126	
34127	catalyzes the methyl esterification of l-isoaspartyl and d-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues. it plays a role in the repair and/or degradation of damaged proteins.
34128	this is the heme a-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
34129	
34130	component of ring canals that regulates the flow of cytoplasm between cells. may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. binds actin.
34131	
34132	
34133	
34134	
34135	
34136	dna-dependent rna polymerase catalyzes the transcription of dna into rna using the four ribonucleoside triphosphates as substrates.
34137	
34138	
34139	
34140	
34141	
34142	
34143	
34144	
34145	functions in nuclear protein import as nuclear transport receptor. serves as receptor for nuclear localization signals (nls) in cargo substrates. is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (npc) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus (by similarity). involved in nuclear import of m9- containing proteins. in vitro, binds directly to the m9 region of the heterogeneous nuclear ribonucleoproteins (hnrnp), a1 and a2 and mediates their nuclear import. appears also to be involved in hnrnp a1/a2 nuclear export. mediates the nuclear import of ribosomal proteins rpl23a, rps7 and rpl5. binds to a beta-like import receptor binding (bib) domain of rpl23a. in vitro, mediates nuclear import of h2a, h2b, h3 and h4 histones, and srp19.
34146	regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. forms complexes with beta-catenin and gamma-catenin/plakoglobin. beta-catenin may be a substrate for the catalytic activity of ptp- kappa.
34147	
34148	
34149	
34150	
34151	
34152	
34153	
34154	may be involved in transcriptional regulation.
34155	
34156	
34157	binds to wnt proteins and inhibits their activities. may be involved in mesoderm segmentation.
34158	
34159	
34160	
34161	
34162	
34163	pre-mrna binding protein in vivo, binds avidly to poly(g) and poly(u) rna homopolymers in vitro. involved in splicing. acts as a receptor for carcinoembryonic antigen in kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of il-1 alpha, il-6, il-10 and tumor necrosis factor alpha cytokines.
34164	dna-binding protein that specifically binds heat shock promoter elements (hse) and activates transcription. in higher eukaryotes, hsf is unable to bind to the hse unless the cells are heat shocked.
34165	
34166	
34167	hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin a.
34168	
34169	
34170	
34171	
34172	
34173	
34174	
34175	
34176	
