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Last Updated: 04/12/2016

DCTD Convenes Workshop on Translational Science in Prostate Cancer

Members of the prostate cancer translational research community participated in a workshop from April 4-5, 2016 at the National Cancer Institute (Agenda). The goal of the workshop was to develop feasible metric- and endpoint-driven studies that will impact the prevention and/or treatment of prostate cancer. The workshop was planned collaboratively by NCI staff from the Translational Research Program (TRP) and prostate cancer investigators funded through the NCI Specialized Programs of Research Excellence (SPOREs) P50 grant funding mechanism. In addition to SPORE investigators and NCI staff within TRP and across NCI, workshop attendees and speakers included members of the broad research community. Workshop participants also were composed of representatives from the Department of Defense, the Prostate Cancer Foundation, the American Urological Association, the Food and Drug Administration, and the Veterans Administration. The co-chairs, Drs. Peter Nelson (Pacific Northwest SPORE in Prostate Cancer), Karen Knudsen (Cancer Center Director, Sidney Kimmel Cancer Center), and William Dahut (Head, Prostate Cancer Clinical Research Section, NCI Center for Cancer Research) led the meeting and provided the conceptual framework for attendees.

The workshop consisted of a series of short presentations describing current studies related to the following crucial areas in translational prostate cancer research:

  • Early Detection and Active Surveillance
  • High-risk Localized and Hormone Sensitive Metastatic Disease
  • Castration Resistant Metastatic Prostate Cancer

Following the presentations, working groups assembled to synthesize tangible research objectives reflecting the above three domains. To accomplish this task, the working groups refined research proposals based on several key actionable questions that participants had industriously prepared in advance of the meeting. The extensive pre-workshop effort was an essential driver of the working groups' success because their time was spent improving the previously identified key questions and proposals. As a result of extensive deliberations on both days of the workshop, the working groups developed blueprints for specific clinical studies. Workshop attendees will collaborate to develop a post-workshop summary that will serve as a guide to future research.