Since this repository began about 50 years ago, more than 500,000 proprietary and nonproprietary compounds have been submitted to the program. In addition to being a repository for NCI screens, the repository distributes compounds for research purposes both as specific vialed compounds and in plated sets for high-throughput screening.
DTP’s plated sets have been instrumental in the discovery of compounds that enhance antilymphoma activity, nucleic acid antagonists with anti-HIV activity, and inhibitors of angiogenin—to name a few important advances.
The Synthetic Products Repository has recently developed a plated set to help evaluate drugs in combination. NCI’s Pediatric Preclinical Testing Program will be one of the first groups to use the new plated sets; the results of the studies will be posted on DTP’s open-use website at: http://dtp.nci.nih.gov.