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U.S. National Institutes of Health
Cancer Diagnosis Program Cancer Imaging Program Cancer Therapy Evaluation Program Developmental Therapeutics Program Radiation Research Program Translational Research Program Biometric Research Branch Office of Cancer Complementary and Alternative Medicine
Last Updated: 04/25/2012

SCIENTIFIC ADVANCES

Contributed by Dr. Joanna Shih

Dr. Joanna Shih collaborated on microarray and genomic studies with investigators from CCR laboratories and branches from 2001 to 2009. In October 2009, Dr. Shih changed her position to collaborate with six CCR branches and labs on general statistics. These six CCR branches are Urologic Oncology Branch, Radiation Oncology Branch, Pediatric Oncology Branch, Metabolism Branch, Molecular Imaging Program, and Neuro-Oncology Branch. Dr. Shih has been working on both design and analysis. Most of the new studies were pilot studies, and some were phase 1/phase 2 non-randomized clinical trials.

In addition to her collaborative research, Dr. Shih is developing statistical methodology, including semi-parametric analysis of failure time data with multi-level clustering, assessing familial association of ages at onset of cancer in the presence of competing risk, estimating the relationship between multivariate longitudinal measurements and time-to-event data, and modeling batched Gaussian longitudinal data subjective to informative dropout.

Orina JN, Calcagno AM, Wu CP, Varma S, Shih JH, Lin M, Eichler G, Weinstein JN, Pommier Y, Ambudkar SV, Gottesman MM, Gillet JP. Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database. Mol Cancer Ther 2009:8;2057-66. http://www.ncbi.nlm.nih.gov/pubmed/19584229

Shih JH, Lu SE. Semiparametric estimation of a nested random effects model for the analysis of multi-level clustered failure time data. Comp Stat Data Anal 2009:53;3864-71. doi:10.1016/j.csda.2009.04.014

Albert PS, Shih JH. On estimating the relationship between longitudinal measurements and time-to-event data using a simple two-stage procedure. Biometrics 2010:66;983-87. http://www.ncbi.nlm.nih.gov/pubmed/20849547

Albert PS, Shih JH. An approach for jointly modeling multivariate longitudinal measurements and time-to-event data. Ann Appl Stat 2010:4;1517-32.

Shih JH, Albert PS. Modeling familial association of ages at onset of diseases in the presence of competing risk. Biometrics 2010:66;1012-23. http://www.ncbi.nlm.nih.gov/pubmed/20002400

Tauler J, Zudaire E, Liu H, Shih J, Mulshine JL. hnRNP A2/B1 modulates epithelial-mesenchymal transition in lung cancer cell lines. Cancer Res 2010:70;7137-47. http://www.ncbi.nlm.nih.gov/pubmed/20807810

Turkbey B, Shah VP, Pang X, Bernado M, Xu S, Kruecker J, Locklin J, Baccala AA, Rastinehad AR, Merino MJ, Shih JH, Wood BJ, Pinto PA, Choyke PL. Is apparent diffusion coefficient associated with clinical risk scores for prostate cancers that are visible on 3-T MR images? Radiology 2010:258;488-95. http://www.ncbi.nlm.nih.gov/pubmed/21177390

Rastinehad AR, Baccal AA, Chung PH, Proano JM, Kruecker J, Xu S, Lockin JK, Turkbey B, Shih J, Linehan WM, Glossop ND, Choyke PL, Wood BJ, Pinto PA. D’amico risk stratification correlates with degree of suspicion of prostate cancer on multi-parametric magnetic resonance imaging. J Urology 2011:185;815-20. doi:10.1016/j.juro.2010.10.076

Albert PS, Shih JH. Modeling batched Gaussian longitudinal data subject to informative dropout. Stat Methods Med Res (In press).

Hipp SJ, Steffen-Smith EA, Hammoud D, Shih JH, Bent R, Warren KE. Predicting outcome of children with diffuse intrinsic pontine gliomas using multiparametric imaging. J Neuro-Oncology (In press).

Yan W, Shih J, Rodriguez-Canales J, Hipp J, Player A, Hu N, Goldstein A, Taylor P, Emmert-Buck M, Erickson H. Identification of Unique Therapeutic Targets in Esophageal Squamous Cell Carcinoma. (Submitted).

Steffen-Smith EA, Shih JH, Warren KE. Proton magnetic resonance spectroscopy predicts survival in children with diffuse intrinsic pontine glioma. (Revision submitted).

Rotunno M, Hu N, Wang C, Goldstein AM, Bergen AW, Consonni D, Pesatori AC, Bertazzi PA, Wacholder S, Shih JH, Caporaso NE, Taylor PR, Landi MT. (2009). A gene expression signature from peripheral whole blood with prognostic implications for lung adenocarcinoma. (Submitted).

Kreisl TN, Zhang W, Odia Y, Shih J, Butman JA, Hammoud D, Iwamoto F, Su J, Fine HA. A Phase II Trial of Single Agent Bevacizumab in Patients with Recurrent Anaplastic Glioma. (Submitted).

Morris JC, Vahanian NN, Rossi GR, Janik JE, Schoonmaker G, Harold N, Schoonmaker C, Shih J, Tennant L, Ramsey WJ, Link CJ. Phase I/II Immunotherapy Study Using α(1,3)Galactosyltransferase-expressing Allogeneic Tumor Cells in Patients with Refractory or Recurrent Non-small Cell Lung Cancer. (Submitted).

Fay M, Shih JH. Weighted logrank tests for interval censored data when assessment times depend on treatment. (Submitted).

Baris T, Mani H, Shah, VJ, Rastinehad AR, Bernardo M, Pohida T, Pang Y, Daar D, Benjamin C, McKinney YL, Trivedi H, Chua C, Bratslavsky G, Shih JH, Linehan WM, Merino MJ, Choyke PL, PintoPA. Multiparametric 3T prostate MR imaging to detect cancer: histopathologic correlation using prostatectomy specimens processed in customized MRI-based molds. (Submitted).

Shuch B, Bratslavsky G, Shih J, Vourganti S, Finley D, Castor B, Treat E, Linehan WM, Pantuck AJ, Said J, Belldegrun AS. Impact of pathologaic tumor characteristics in patients with sarcomatoid renal cell carcinoma. (Submitted).

Chen J, Petrus M, Bamford R, Shih JH, Morris JC, Janik JE, Waldmann TA. Increased serum soluble interleukin-15 receptor alpha (sIL-15Rα) levels in T cell large granular lymphocyte leukemia. (Submitted).

Simone NL, Dan T, Shih JH, Smith SL, Sciuto L, Lita E, Swain SM, Danforth D, Camphausen K. Twenty-five year results in the treatment of early stage breast carcinoma with mastectomy versus breast conservation therapy: the National Cancer Institute randomized trial. (Submitted).

Zhang C, Elkahloun AG, Robertson M, Gills JJ, Tsurutani J, Shih JH, Fukuoka J, Hollander C, Harris CC, Travis WD, Jen J, Dennis PA. Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance. (Submitted).

Yan W, Shih J, Rodriguez-Canales J, Hipp J, Player A, Hu N, Goldstein AM, Taylor PR, Emmert-Buck MR, Erickson HS. Identification of unique therapeutic targets in esophageal squamous cell carcinoma. (Submitted).