SAHA is a potent histone deactylase (HDAC) inhibitor with excellent oral bioavailability. Histone acetylation affects the regulation of gene expression and HDAC inhibitors may cause growth arrest, differentiation, and/or apoptosis of may transformed cells by altering the transcription of a small number of key genes. The HDAC inhibitors' activity in several animal models of solid tumors and leukemias, at doses that cause little apparent toxicity, suggest that these agents may be a new class of anticancer therapeutics.
Screening data summary reports for individual experiments using the DTP invivo solid tumor and/or toxicity testing models are available below. Comments are based upon the results of individual experiments. Variations in outcome can result from changes in many experimental variables including the drug doses, administration routes, dosing schedules, drug vehicles, tumor models and tumor passage status.