Last Updated: 02/16/09
Scientific Advances
Changes to Early and Late Translational Research at NCI
The National Cancer Advisory Board (NCAB), within the last 4 years, has convened two broad-based panels to examine early and late translational research at NCI. The Clinical Trials Working Group (CTWG) More…
Phase 0 Scientific Articles
Phase 0 Scientific Articles by Division of Cancer Treatment and Diagnosis and Center for Cancer Research Staff More…
More Phase 0 Activities
A new assay that has been developed for phase 0 trials measures the presence of γ-H2AX in tumor tissue. γ-H2AX is a phosphorylated version of the histone H2AX that is made when DNA is damaged in a cell. The More…
Phase 0 Imaging Agent Study
Imaging agents are also being developed as part of the NExT program. The growing interest in these agents stems from their potential to diagnose, stage, manage, monitor, and even treat tumors. One such agent under development is 111Indium-trastuzumab. More…
Results of Six Imaging Clinical Trials
Findings from six medical imaging clinical trials coordinated by ACRIN were presented during the network’s 2007 Fall Meeting in Arlington, Virginia. Key results presented include: More…
Pilot Study: Ferumoxytol in Magnetic Resonance Studies of Brain Tumors
A CIP-funded pilot study at Oregon Health and Science University is investigating the potential role of ferumoxytol in MRI of malignant brain tumors. Ferumoxytol is an iron oxide nanoparticle that targets More…
Low-dose Steroid Combined with Lenalidomide Prolongs Survival Compared with High-dose Steroid for Multiple Myeloma Treatment
High-dose steroids have been a standard component of multiple myeloma therapy for decades. Although the use of high-dose steroids was recognized as toxic, the assumption was that the high doses of steroids More…
Arsenic Compound Improves Survival of Adults with Uncommon Form of Leukemia
A phase III intergroup led by the CALGB trial demonstrated a positive benefit from consolidation therapy with arsenic trioxide ( As2O3) on event-free survival and overall survival among patients with newly diagnosed More…
Highly Effective, Less Toxic Therapy for Mature B-cell non-Hodgkin Lymphoma (NHL) in Children
The FAB/LMB96 trial for children with mature B-cell NHL, such as Burkitt lymphoma, was an international collaboration that included COG researchers as well as investigators from France and the United Kingdom. More…
Imatinib Mesylate Decreases Cancer Recurrence for Patients with Primary Gastrointestinal Stromal Tumor
Preliminary results from a large, randomized, placebo-controlled clinical trial for patients with primary gastrointestinal stromal tumor (GIST) demonstrated that patients who received imatinib mesylate after More…
From the Sea to Clinical Trials
Dr. William Fenical at the Scripps Institution of Oceanography (SIO), University of California at San Diego (UCSD), is an internationally recognized leader in the field of marine natural products. His research has More…
Enhancing Treatment Accuracy and Precision
A goal in modern radiotherapy is to shape the radiation field closely to the tumor in 3-dimensions to minimize the risk of radiation damage to the normal tissues surrounding the tumor. In some tumor sites, More…
Improving Outcome for Patients with Brain Tumors
Patients with brain tumors are often treated with radiotherapy to the brain. Unfortunately, 20 to 50 percent of these patients experience a progressive dementia because of the effects of the radiation on normal brain More…
Radiation Quality Assurance for High-Technology Treatment – Advanced Technology Consortium
The Advanced Technology Quality Assurance Consortium (ATC) capitalizes on the infrastructure and strengths of the nation's existing quality assurance (QA) programs—including the Image-Guided Therapy More…
